Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LRP1B	53353	broad.mit.edu	37	2	141245239	141245239	+	Nonsense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:141245239G>A	ENST00000389484.3	-	58	10161	c.9190C>T	c.(9190-9192)Cga>Tga	p.R3064*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3064					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCATTGGGTCGGCTAGAATCG	0.313000										TSP Lung(27;0.18)			3	77					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626483	49626483	+	Silent	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr20:49626483C>T	ENST00000371571.4	-	2	678	c.393G>A	c.(391-393)ctG>ctA	p.L131L	KCNG1_ENST00000396017.3_Silent_p.L131L|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	131						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						TGCCCGCGCGCAGGAAGGTCA	0.642000													16	25					0	0	1	0	0
ASB18	401036	broad.mit.edu	37	2	237150049	237150049	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:237150049C>T	ENST00000330842.6	-	1	209	c.115G>A	c.(115-117)Gca>Aca	p.A39T	AC079135.1_ENST00000415226.1_RNA|ASB18_ENST00000409749.3_Intron			Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box containing 18	68					intracellular signal transduction					large_intestine(1)|lung(3)|ovary(1)|prostate(1)	6		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		AGGTCCCCTGCGACCAGGGCA	0.522000													12	20					0	0	1	0	0
NINJ1	4814	broad.mit.edu	37	9	95888798	95888798	+	Silent	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr9:95888798G>A	ENST00000375446.4	-	2	268	c.198C>T	c.(196-198)gcC>gcT	p.A66A		NM_004148.3	NP_004139.2	Q92982	NINJ1_HUMAN	ninjurin 1	66					cell adhesion|nervous system development|tissue regeneration	integral to membrane				kidney(1)|large_intestine(2)|upper_aerodigestive_tract(1)	4						GTTCCACGACGGCCTTCAGCT	0.622000													6	57					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42522547	42522547	+	Missense_Mutation	SNP	G	G	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:42522547G>T	ENST00000318522.5	+	13	1642	c.1380G>T	c.(1378-1380)caG>caT	p.Q460H	EML4_ENST00000401738.3_Missense_Mutation_p.Q471H|EML4_ENST00000402711.2_Missense_Mutation_p.Q402H	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	460					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						AATTTGTGCAGTGTTTAGCAT	0.358000			T	ALK	NSCLC								8	50					0.0692343	0.070351	1	1	0
TPO	7173	broad.mit.edu	37	2	1488493	1488493	+	Silent	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:1488493C>T	ENST00000345913.4	+	9	1555	c.1464C>T	c.(1462-1464)gcC>gcT	p.A488A	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000337415.3_Silent_p.A488A|TPO_ENST00000382198.1_Silent_p.A315A|TPO_ENST00000382201.3_Silent_p.A488A|TPO_ENST00000349624.3_Silent_p.A315A|TPO_ENST00000346956.3_Silent_p.A488A|TPO_ENST00000329066.4_Silent_p.A488A	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	488					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCTCCACAGCCGCCTTCCGCT	0.662000													13	33					0	0	1	0	0
IGHV1-18	0	broad.mit.edu	37	14	106641640	106641640	+	RNA	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:106641640C>T	ENST00000390605.2	-	0	332																											GTGGATGTGTCTGTGGTCATG	0.542000													79	158					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29614328	29614328	+	Splice_Site	SNP	G	G	A	rs137860963	by1000genomes	TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr20:29614328G>A	ENST00000278882.3	+	2	320		c.e2+1		FRG1B_ENST00000439954.2_Splice_Site|FRG1B_ENST00000358464.4_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGATACGTTGGTGAGTCAGTT	0.289000													3	17					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215866294	215866294	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:215866294C>T	ENST00000272895.7	-	21	3070	c.2851G>A	c.(2851-2853)Gaa>Aaa	p.E951K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E633K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	951					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCAAAGAGTTCGTTGCTTTTG	0.383000													5	96					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632730	30632730	+	Missense_Mutation	SNP	T	T	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr6:30632730T>C	ENST00000376442.3	-	7	1360	c.1165A>G	c.(1165-1167)Aaa>Gaa	p.K389E		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	389					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						ATGGACTCTTTCTGCTGGGCC	0.552000													15	22					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198725090	198725090	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:198725090G>A	ENST00000367376.2	+	33	3866	c.3695G>A	c.(3694-3696)gGa>gAa	p.G1232E	PTPRC_ENST00000352140.3_Missense_Mutation_p.G1184E|PTPRC_ENST00000594404.1_Missense_Mutation_p.G1071E|PTPRC_ENST00000348564.6_Missense_Mutation_p.G1073E|PTPRC_ENST00000442510.2_Missense_Mutation_p.G1234E	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1232					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GCTCAGAATGGACAAGTAAAG	0.363000													24	44					0	0	1	0	0
UGT1A10	0	broad.mit.edu	37	2	234545792	234545792	+	Missense_Mutation	SNP	G	G	T	rs144759885		TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:234545792G>T	ENST00000344644.5	+	1	693	c.624G>T	c.(622-624)tgG>tgT	p.W208C	UGT1A10_ENST00000373445.1_Missense_Mutation_p.W208C|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGAGAGTATGGAACCACATCG	0.458000													5	199					0.00116845	0.00122687	1	1	0
RRAS	6237	broad.mit.edu	37	19	50138860	50138860	+	Silent	SNP	G	G	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr19:50138860G>T	ENST00000246792.3	-	6	732	c.630C>A	c.(628-630)ggC>ggA	p.G210G		NM_006270.3	NP_006261.1	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	210					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(2)	6				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GGCAGCCCCCGCCCTTCTTCC	0.617000													20	62					0.000229342	0.00024489	1	1	0
HELB	92797	broad.mit.edu	37	12	66698594	66698594	+	Missense_Mutation	SNP	G	G	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr12:66698594G>C	ENST00000247815.4	+	2	330	c.271G>C	c.(271-273)Gta>Cta	p.V91L		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	91					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GAGAGTGAAGGTACAAGTAAA	0.378000													12	66					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136623784	136623784	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:136623784C>T	ENST00000264156.2	-	6	905	c.845G>A	c.(844-846)cGa>cAa	p.R282Q		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	282					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CCGGAGTCCTCGAATGCCTTC	0.488000													15	95					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16671017	16671017	+	Missense_Mutation	SNP	C	C	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr5:16671017C>A	ENST00000513610.1	-	39	5955	c.5501G>T	c.(5500-5502)cGa>cTa	p.R1834L	MYO10_ENST00000427430.2_Missense_Mutation_p.R1191L|MYO10_ENST00000515803.1_Missense_Mutation_p.R1173L|MYO10_ENST00000274203.9_Missense_Mutation_p.R1191L|MYO10_ENST00000505695.1_Missense_Mutation_p.R1173L	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1834	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						ATACTGGAGTCGCAGGGCAGC	0.567000													6	18					1.6384e-10	1.81086e-10	1	1	0
IFIT5	24138	broad.mit.edu	37	10	91177745	91177745	+	Missense_Mutation	SNP	T	T	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr10:91177745T>A	ENST00000371795.4	+	2	1002	c.789T>A	c.(787-789)aaT>aaA	p.N263K	IFIT5_ENST00000416601.1_Missense_Mutation_p.N215K	NM_012420.2	NP_036552.1	Q13325	IFIT5_HUMAN	interferon-induced protein with tetratricopeptide repeats 5	263							binding			endometrium(1)|large_intestine(4)|lung(4)	9						GGAGAAAAAATTCCTGGAACA	0.433000													12	63					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158632713	158632713	+	Missense_Mutation	SNP	T	T	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:158632713T>C	ENST00000368148.3	-	17	2423	c.2243A>G	c.(2242-2244)gAc>gGc	p.D748G	SPTA1_ENST00000368147.3_Missense_Mutation_p.D748G	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	748					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGCAGCCAGGTCTGTAAGGAT	0.423000													19	39					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55826543	55826543	+	Missense_Mutation	SNP	C	C	A	rs148162562		TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr10:55826543C>A	ENST00000373965.2	-	19	2609	c.2215G>T	c.(2215-2217)Gcc>Tcc	p.A739S	PCDH15_ENST00000395433.1_Missense_Mutation_p.A710S|PCDH15_ENST00000395445.1_Missense_Mutation_p.A739S|PCDH15_ENST00000373955.1_Missense_Mutation_p.A732S|PCDH15_ENST00000414778.1_Missense_Mutation_p.A737S|PCDH15_ENST00000361849.3_Missense_Mutation_p.A732S|PCDH15_ENST00000395430.1_Missense_Mutation_p.A732S|PCDH15_ENST00000373957.3_Missense_Mutation_p.A710S|PCDH15_ENST00000437009.1_Missense_Mutation_p.A661S|PCDH15_ENST00000395432.2_Missense_Mutation_p.A695S|PCDH15_ENST00000409834.1_Missense_Mutation_p.A343S|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Missense_Mutation_p.A732S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.A732S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	732	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AAGGCATTGGCTTCTTCTTCC	0.343000										HNSCC(58;0.16)			12	41					7.93312e-07	8.61701e-07	1	1	0
SLC6A5	9152	broad.mit.edu	37	11	20652328	20652328	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr11:20652328C>T	ENST00000525748.1	+	10	1864	c.1591C>T	c.(1591-1593)Cgc>Tgc	p.R531C	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	531					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	GGCCAATGAACGCAAAGTCAA	0.507000													5	35					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94173180	94173180	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:94173180G>A	ENST00000553484.1	+	51	8058	c.7904G>A	c.(7903-7905)tGc>tAc	p.C2635Y	UNC79_ENST00000555664.1_Missense_Mutation_p.C2574Y|UNC79_ENST00000256339.4_Missense_Mutation_p.C2436Y|UNC79_ENST00000393151.2_Missense_Mutation_p.C2613Y			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2613						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGGTTGCAGTGCACTCAGTTC	0.577000													10	56					0	0	1	0	0
IGHG3	0	broad.mit.edu	37	14	106237046	106237046	+	RNA	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:106237046G>A	ENST00000390551.2	-	0	304																											CACCAAGTGGGGTTTTGAGCT	0.572000													58	61					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158608031	158608031	+	Splice_Site	SNP	C	C	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:158608031C>A	ENST00000368148.3	-	36	5161	c.4980_splice	c.e36-1	p.D1661_splice	SPTA1_ENST00000368147.3_Splice_Site_p.D1661_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1661					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTGAGTGCATCCTAGAAAGTC	0.433000													6	27					0.00198382	0.00204886	1	1	0
TAF1D	79101	broad.mit.edu	37	11	93469412	93469412	+	Missense_Mutation	SNP	T	T	G	rs76450167		TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr11:93469412T>G	ENST00000448108.2	-	6	1402	c.752A>C	c.(751-753)gAa>gCa	p.E251A		NM_024116.3	NP_077021.1	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			large_intestine(1)|lung(3)|prostate(1)|skin(2)	7						AATATCCTCTTCTTCTAAGTA	0.363000													22	36					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85924472	85924472	+	Missense_Mutation	SNP	A	A	G			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr9:85924472A>G	ENST00000304195.3	-	10	1111	c.905T>C	c.(904-906)gTg>gCg	p.V302A	FRMD3_ENST00000376434.1_Missense_Mutation_p.V108A|FRMD3_ENST00000376438.1_Missense_Mutation_p.V302A	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	302	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CTGGTTTTCCACTCCACACTT	0.348000													12	32					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5545497	5545497	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr6:5545497G>A	ENST00000324331.6	+	5	1325	c.989G>A	c.(988-990)cGt>cAt	p.R330H	FARS2_ENST00000274680.4_Missense_Mutation_p.R330H			O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2, mitochondrial	330					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding	p.R330H(1)		endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)|stomach(2)	15	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	CCTGATATCCGTCTCTTCTGG	0.473000													46	89					0	0	1	0	0
RALY	22913	broad.mit.edu	37	20	32664877	32664877	+	Silent	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr20:32664877C>T	ENST00000375114.3	+	7	1232	c.654C>T	c.(652-654)ggC>ggT	p.G218G	RALY_ENST00000246194.3_Silent_p.G234G	NM_007367.3	NP_031393.2	Q9UKM9	RALY_HUMAN	RALY heterogeneous nuclear ribonucleoprotein	234						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						gcggcggcggcggtggtggtg	0.667000													3	11					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408302	105408302	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:105408302C>T	ENST00000333244.5	-	7	13605	c.13486G>A	c.(13486-13488)Gac>Aac	p.D4496N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4496						nucleus		p.D4496N(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGCTCATGTCGGCCTCCATC	0.587000													13	175					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678541	88678541	+	Missense_Mutation	SNP	G	G	A	rs145157285	by1000genomes	TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr15:88678541G>A	ENST00000394480.1	-	10	1316	c.995C>T	c.(994-996)aCg>aTg	p.T332M	NTRK3_ENST00000540489.2_Missense_Mutation_p.T332M|NTRK3_ENST00000355254.2_Missense_Mutation_p.T332M|NTRK3_ENST00000357724.2_Missense_Mutation_p.T332M|NTRK3_ENST00000558676.1_Missense_Mutation_p.T332M|NTRK3_ENST00000360948.2_Missense_Mutation_p.T332M|NTRK3_ENST00000317501.3_Missense_Mutation_p.T332M|NTRK3_ENST00000542733.2_Missense_Mutation_p.T234M|NTRK3_ENST00000557856.1_Missense_Mutation_p.T332M	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	332	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.T332M(3)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCAGTGCAGCGTTGGTGGGGG	0.602000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			24	37					0	0	1	0	0
NDST2	8509	broad.mit.edu	37	10	75567489	75567489	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr10:75567489C>T	ENST00000299641.4	-	4	1259	c.289G>A	c.(289-291)Ggg>Agg	p.G97R	NDST2_ENST00000309979.6_Missense_Mutation_p.G220R	NM_003635.3	NP_003626.1	P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	220	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					GGCAGTGGCCCTGGTTCTAGG	0.557000													15	14					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192359	152192359	+	Silent	SNP	A	A	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:152192359A>T	ENST00000368801.2	-	3	1821	c.1746T>A	c.(1744-1746)tcT>tcA	p.S582S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	582					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTAAGCCAGAAGAGTGAC	0.562000													24	194					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583677	47583677	+	Silent	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr17:47583677C>T	ENST00000172229.3	+	3	350	c.225C>T	c.(223-225)gaC>gaT	p.D75D	RP5-1029K10.2_ENST00000514506.1_RNA|NGFR_ENST00000504201.1_5'UTR	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	75					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CGTTCTCCGACGTGGTGAGCG	0.672000													5	51					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120960123	120960123	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr12:120960123C>T	ENST00000288532.6	-	2	286	c.246G>A	c.(244-246)atG>atA	p.M82I	COQ5_ENST00000445328.2_Missense_Mutation_p.M82I	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	82					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCATATCATTCATCACATCAT	0.438000													4	62					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169391324	169391324	+	Missense_Mutation	SNP	C	C	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:169391324C>A	ENST00000545005.1	-	4	852	c.345G>T	c.(343-345)ttG>ttT	p.L115F	CCDC181_ENST00000491570.1_5'UTR|CCDC181_ENST00000367806.3_Missense_Mutation_p.L115F|CCDC181_ENST00000367805.3_Missense_Mutation_p.L115F					coiled-coil domain containing 181																		CTTCCTCCTCCAAGTCTTTCT	0.388000													6	50					0.217242	0.217242	1	1	0
PROX2	283571	broad.mit.edu	37	14	75329862	75329862	+	Silent	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:75329862G>A	ENST00000556084.2	-	1	675	c.676C>T	c.(676-678)Ctg>Ttg	p.L226L	PROX2_ENST00000445876.1_Silent_p.L226L|PROX2_ENST00000556489.2_Silent_p.L226L	NM_001080408.2	NP_001073877.2	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	226					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		TCTTTCCTCAGAATCTCTAGT	0.537000													22	36					0	0	1	0	0
KRR1	11103	broad.mit.edu	37	12	75893616	75893616	+	Missense_Mutation	SNP	A	A	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr12:75893616A>C	ENST00000229214.4	-	10	1142	c.1119T>G	c.(1117-1119)gaT>gaG	p.D373E	KRR1_ENST00000438169.2_Missense_Mutation_p.D316E|GLIPR1_ENST00000266659.3_3'UTR	NM_007043.6	NP_008974.5	Q13601	KRR1_HUMAN	KRR1, small subunit (SSU) processome component, homolog (yeast)	373	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						TTTTCTTTTCATCTGCCTCCA	0.358000													14	25					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70960066	70960066	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr15:70960066G>A	ENST00000322954.6	-	16	3142	c.2957C>T	c.(2956-2958)gCc>gTc	p.A986V	UACA_ENST00000560441.1_Missense_Mutation_p.A971V|UACA_ENST00000379983.2_Missense_Mutation_p.A973V|UACA_ENST00000539319.1_Missense_Mutation_p.A877V	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	986						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						GACAATTGGGGCGTATTTTAC	0.403000													4	120					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30953765	30953765	+	Missense_Mutation	SNP	A	A	G			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr21:30953765A>G	ENST00000399914.1	-	12	2368	c.1847T>C	c.(1846-1848)gTt>gCt	p.V616A	GRIK1_ENST00000399909.1_Missense_Mutation_p.V616A|GRIK1_ENST00000399913.1_Missense_Mutation_p.V631A|GRIK1_ENST00000389124.2_Missense_Mutation_p.V631A|GRIK1_ENST00000327783.4_Missense_Mutation_p.V631A|GRIK1_ENST00000309434.7_Missense_Mutation_p.V633A|GRIK1_ENST00000535441.1_Missense_Mutation_p.V633A|GRIK1_ENST00000389125.3_Missense_Mutation_p.V616A|GRIK1_ENST00000399907.1_Missense_Mutation_p.V631A			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	631					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GAGAGCTCCAACTCCAAACCA	0.478000													5	46					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149497093	149497093	+	RNA	SNP	G	G	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr7:149497093G>C	ENST00000378016.2	+	0	7132							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACCCCTGCTGGTAAGATGCCA	0.612000													5	21					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284255	152284255	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:152284255C>T	ENST00000368799.1	-	3	3142	c.3107G>A	c.(3106-3108)cGc>cAc	p.R1036H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1036	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTGGTGGCGGGATCCGTG	0.562000									Ichthyosis				6	464					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919255	21919255	+	Missense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr12:21919255C>T	ENST00000240662.2	-	3	1022	c.677G>A	c.(676-678)cGc>cAc	p.R226H	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	226						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	CACCTGGATGCGCACAGAGGC	0.493000													45	65					0	0	1	0	0
AP000295.9	0	broad.mit.edu	37	21	34640775	34640775	+	Missense_Mutation	SNP	A	A	G			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr21:34640775A>G	ENST00000433395.2	+	4	509	c.509A>G	c.(508-510)cAc>cGc	p.H170R	IL10RB_ENST00000290200.2_Silent_p.S42S																							AGTGGGAGTCACCTGCTTTTG	0.473000													7	72					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240070781	240070781	+	Silent	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:240070781G>A	ENST00000255380.4	+	5	809	c.30G>A	c.(28-30)tcG>tcA	p.S10S		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	10					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GTACAACCTCGCCTTTGTTTC	0.483000													4	59					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1377682	1377682	+	Nonsense_Mutation	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr4:1377682C>T	ENST00000389851.4	+	13	2437	c.1990C>T	c.(1990-1992)Cag>Tag	p.Q664*	UVSSA_ENST00000511563.1_Nonsense_Mutation_p.Q215*|UVSSA_ENST00000511216.1_Nonsense_Mutation_p.Q664*|UVSSA_ENST00000507531.1_Nonsense_Mutation_p.Q664*|UVSSA_ENST00000512728.1_Nonsense_Mutation_p.Q215*	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	664																	CCTGAAGGCTCAGGCTGATAC	0.637000													6	49					0	0	1	0	0
LCE1C	353133	broad.mit.edu	37	1	152777704	152777704	+	Missense_Mutation	SNP	C	C	G			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:152777704C>G	ENST00000368768.1	-	2	301	c.251G>C	c.(250-252)aGg>aCg	p.R84T	LCE1C_ENST00000607093.1_Missense_Mutation_p.R84T	NM_178351.3	NP_848128.1	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	84	Gly-rich.				keratinization					NS(1)|lung(4)|prostate(1)|skin(2)|urinary_tract(1)	9	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGTGGGACCTACGGCGCCT	0.701000													10	55					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66478213	66478213	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr11:66478213G>A	ENST00000533211.1	-	10	1244	c.913C>T	c.(913-915)Cgc>Tgc	p.R305C	SPTBN2_ENST00000529997.1_Missense_Mutation_p.R305C|SPTBN2_ENST00000309996.2_Missense_Mutation_p.R305C			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	305					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						TCCACCAGGCGCTCTGCCTCC	0.627000													3	40					0	0	1	0	0
ETV3	2117	broad.mit.edu	37	1	157105362	157105362	+	Missense_Mutation	SNP	C	C	G			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:157105362C>G	ENST00000368192.4	-	3	249	c.185G>C	c.(184-186)gGg>gCg	p.G62A	ETV3_ENST00000326786.4_Missense_Mutation_p.G62A|ETV3_ENST00000460850.1_5'UTR	NM_001145312.1	NP_001138784.1	P41162	ETV3_HUMAN	ets variant 3	62							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	9	Hepatocellular(266;0.158)	Prostate(1639;0.174)				GACAAATTCCCCGTACTCTCC	0.592000													15	38					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76555114	76555114	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr16:76555114G>A	ENST00000307431.8	+	17	2825	c.2440G>A	c.(2440-2442)Gcg>Acg	p.A814T	CNTNAP4_ENST00000476707.1_Missense_Mutation_p.A818T|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.A742T|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.A766T	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	815	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.A742T(1)|p.A814T(1)		breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGAACTTAGCGCGGATGTATC	0.383000													23	58					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186394861	186394861	+	Missense_Mutation	SNP	C	C	T	rs143855375	by1000genomes	TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr3:186394861C>T	ENST00000232003.4	+	7	847	c.767C>T	c.(766-768)cCg>cTg	p.P256L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	256					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding	p.P256Q(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		AATGGTGTACCGCCTCATTTG	0.448000													35	70					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752464	2752464	+	Silent	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr7:2752464C>T	ENST00000312371.4	+	7	1817	c.1449C>T	c.(1447-1449)ctC>ctT	p.L483L	AMZ1_ENST00000407112.1_3'UTR|AMZ1_ENST00000489665.1_Intron	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	483							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCCGAAAACTCGCCAGAGCAG	0.647000													11	41					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043995	25043995	+	Silent	SNP	G	G	A	rs143803246		TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr14:25043995G>A	ENST00000216336.2	-	3	261	c.225C>T	c.(223-225)ggC>ggT	p.G75G		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	75	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity	p.G75G(1)		autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		TATTGTGGGCGCCCAGGGTGA	0.557000													5	60					0	0	1	0	0
MOCS2	4338	broad.mit.edu	37	5	52394453	52394453	+	Silent	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr5:52394453G>A	ENST00000396954.3	-	7	1223	c.546C>T	c.(544-546)tgC>tgT	p.C182C	MOCS2_ENST00000510818.2_3'UTR|MOCS2_ENST00000508922.1_3'UTR|MOCS2_ENST00000361377.4_3'UTR|MOCS2_ENST00000450852.3_3'UTR|MOCS2_ENST00000584946.1_3'UTR|MOCS2_ENST00000582677.1_3'UTR	NM_004531.3	NP_004522.1	O96033	MOC2A_HUMAN	molybdenum cofactor synthesis 2	0					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding			endometrium(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				ATGCCCAAAAGCACTCTTTGT	0.289000													7	36					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669493	158669493	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:158669493G>A	ENST00000359610.2	-	1	993	c.950C>T	c.(949-951)cCa>cTa	p.P317L		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	317					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TGAGGTCCCTGGTCTTACGGA	0.373000													16	32					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111638	55111638	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr11:55111638G>A	ENST00000314721.2	+	1	1012	c.962G>A	c.(961-963)aGt>aAt	p.S321N		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TTTATTCCTAGTTCTAAGGCA	0.343000													13	14					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220275731	220275731	+	Silent	SNP	T	T	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:220275731T>A	ENST00000366922.1	+	5	841	c.510T>A	c.(508-510)ccT>ccA	p.P170P	IARS2_ENST00000302637.5_Silent_p.P242P			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	242					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CTTACAAACCTGTGTTTTGGT	0.308000													3	45					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56330243	56330243	+	Missense_Mutation	SNP	G	G	A			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr3:56330243G>A	ENST00000288221.6	-	3	1133	c.878C>T	c.(877-879)aCg>aTg	p.T293M		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	293						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TTGTTTCTGCGTTTCAATTCT	0.458000													11	235					0	0	1	0	0
LINC00471	0	broad.mit.edu	37	2	232373921	232373921	+	RNA	SNP	C	C	T			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr2:232373921C>T	ENST00000313064.2	-	0	497					NR_024079.1																						GTGGCTCTCACGGTCCTTGAG	0.522000													4	114					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35824942	35824942	+	Frame_Shift_Del	DEL	G	G	-			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:35824942delG	ENST00000314607.6	+	3	582	c.502delG	c.(502-504)gafs	p.G168fs	ZMYM4-AS1_ENST00000432683.1_RNA|ZMYM4_ENST00000373297.2_Frame_Shift_Del_p.G168fs	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	168					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GACATTTTCTGGAAAGGAGAA	0.313													14	34	---	---	---	---					
RP11-343N15.1	0	broad.mit.edu	37	1	121137791	121137793	+	RNA	DEL	CCA	CCA	-	rs28552466	by1000genomes	TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr1:121137791_121137793delCCA	ENST00000437515.1	-	0	329																											ATTTCGCCCTCCACCGCCGCCGC	0.631													4	5	---	---	---	---					
JRK	8629	broad.mit.edu	37	8	143747534	143747534	+	RNA	DEL	C	C	-			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr8:143747534delC	ENST00000507178.2	-	0	276									jerky homolog (mouse)													all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				TGGGCTGCTGCCACTACTTCC	0.667													2	4	---	---	---	---					
TEX10	54881	broad.mit.edu	37	9	103066107	103066108	+	Frame_Shift_Ins	INS	-	-	C			TCGA-Y6-A9XI-01A-11D-A41K-08	TCGA-Y6-A9XI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19093082-7365-4b1e-aeea-9a7203bf78a3	7720c12c-81ea-41fc-a13c-48fcc8d219b8	g.chr9:103066107_103066108insC	ENST00000374902.4	-	14	2658_2659	c.2482_2483insG	c.(2482-2484)ctgfs	p.L828fs	TEX10_ENST00000477648.1_5'UTR|TEX10_ENST00000535814.1_Intron	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	828						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		GGAGACACAGACCCCCCACAGC	0.545													9	39	---	---	---	---