Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HUWE1	10075	broad.mit.edu	37	X	53586378	53586378	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chrX:53586378G>C	ENST00000342160.3	-	56	8309	c.7852C>G	c.(7852-7854)Cgt>Ggt	p.R2618G	HUWE1_ENST00000262854.6_Missense_Mutation_p.R2618G			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2618					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TCATCAGAACGGGCGATGATG	0.557000													22	8					0	0	1	0	0
GJA3	2700	broad.mit.edu	37	13	20717018	20717018	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr13:20717018C>T	ENST00000241125.3	-	2	586	c.410G>A	c.(409-411)gGc>gAc	p.G137D		NM_021954.3	NP_068773.2	Q9Y6H8	CXA3_HUMAN	gap junction protein, alpha 3, 46kDa	137					cell-cell signaling|visual perception	connexon complex|integral to membrane				NS(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		GCGCACCCTGCCGCGGTCGTC	0.627000													5	5					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62324513	62324513	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr20:62324513C>T	ENST00000318100.4	+	30	3696	c.2869C>T	c.(2869-2871)Cgg>Tgg	p.R957W	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.R957W|RTEL1_ENST00000360203.5_Missense_Mutation_p.R957W|RTEL1_ENST00000370003.1_Missense_Mutation_p.R202W|RTEL1_ENST00000370018.3_Missense_Mutation_p.R957W|RTEL1_ENST00000508582.2_Missense_Mutation_p.R981W			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	957					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CCAGTTTGTGCGGCCCCACCA	0.597000													4	106					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43926922	43926922	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr2:43926922C>G	ENST00000282406.4	+	8	935	c.825C>G	c.(823-825)atC>atG	p.I275M		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	275						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATGGTGGCATCTCCCAGAATT	0.502000													6	31					0	0	1	0	0
PDK1	5163	broad.mit.edu	37	2	173451073	173451073	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr2:173451073C>G	ENST00000410055.1	+	9	1113	c.1013C>G	c.(1012-1014)aCt>aGt	p.T338S	PDK1_ENST00000392571.2_Missense_Mutation_p.T358S|PDK1_ENST00000282077.2_Missense_Mutation_p.T338S|PDK1_ENST00000543905.1_Missense_Mutation_p.T262S|PDK1_ENST00000544863.1_Missense_Mutation_p.T183S	NM_002610.3	NP_002601.1	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase, isozyme 1	338	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.12)			ATGTATTCAACTGCACCAAGA	0.453000									Autosomal Dominant Polycystic Kidney Disease				8	27					0	0	1	0	0
DCAF10	79269	broad.mit.edu	37	9	37842147	37842147	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr9:37842147C>A	ENST00000242323.7	+	3	789	c.715C>A	c.(715-717)Ctg>Atg	p.L239M	RP11-613M10.9_ENST00000540557.1_Intron|DCAF10_ENST00000377724.3_Missense_Mutation_p.L239M			Q5QP82	DCA10_HUMAN	DDB1 and CUL4 associated factor 10	239						CUL4 RING ubiquitin ligase complex				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	12						ACTATGGGATCTGAGAAAATT	0.378000													21	26					2.89027e-11	3.12621e-11	1	1	0
GABRB2	0	broad.mit.edu	37	5	160972256	160972256	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr5:160972256C>T	ENST00000274547.2	-	4	431	c.214G>A	c.(214-216)Gat>Aat	p.D72N	GABRB2_ENST00000393959.1_Missense_Mutation_p.D72N|GABRB2_ENST00000353437.6_Missense_Mutation_p.D72N|GABRB2_ENST00000517547.1_5'UTR|GABRB2_ENST00000520240.1_Missense_Mutation_p.D72N|GABRB2_ENST00000517901.1_Missense_Mutation_p.D9N	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	72					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAAACCATATCGATGCTGGCA	0.458000													4	19					0	0	1	0	0
MRPL14	64928	broad.mit.edu	37	6	44084306	44084306	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr6:44084306T>C	ENST00000372014.3	-	2	174	c.43A>G	c.(43-45)Agc>Ggc	p.S15G		NM_032111.2	NP_115487.2	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14	15					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			AGCACTCTGCTTACACAGGTG	0.463000													21	78					0	0	1	0	0
LPCAT4	254531	broad.mit.edu	37	15	34653605	34653605	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr15:34653605T>A	ENST00000314891.6	-	11	1316	c.1139A>T	c.(1138-1140)cAg>cTg	p.Q380L		NM_153613.2	NP_705841.2	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	380					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding			NS(1)|breast(1)|large_intestine(2)|lung(5)|prostate(1)	10						CTTTACCTGCTGGAAGTAGCC	0.562000													18	53					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363008	22363008	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr19:22363008C>G	ENST00000397121.2	-	3	1828	c.1511G>C	c.(1510-1512)cGc>cCc	p.R504P		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGCGTTTCTCTCC	0.388000													6	81					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46347341	46347341	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr19:46347341C>A	ENST00000245934.7	-	8	1038	c.794G>T	c.(793-795)cGc>cTc	p.R265L		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	265					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGGTCTCTGGCGGGCGATATT	0.582000													4	64					1	1	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													3	51					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608686	4608686	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr11:4608686C>T	ENST00000312614.4	+	1	666	c.644C>T	c.(643-645)gCc>gTc	p.A215V		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A215V(1)		endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCTTTGGCCAGGTTAGCA	0.512000													4	114					0	0	1	0	0
MRPL19	9801	broad.mit.edu	37	2	75881964	75881964	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr2:75881964C>T	ENST00000393909.2	+	5	603	c.578C>T	c.(577-579)gCc>gTc	p.A193V	MRPL19_ENST00000358788.6_Intron|MRPL19_ENST00000409374.1_Missense_Mutation_p.A193V	NM_014763.3	NP_055578.2	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19	193					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(6)	8						TTACGAGATGCCCTTCCTGAA	0.398000													3	46					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829055	115829055	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr1:115829055C>T	ENST00000369512.2	-	3	530	c.362G>A	c.(361-363)cGg>cAg	p.R121Q	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	121					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GGATGATGACCGCTTGCTCCT	0.587000													4	25					0	0	1	0	0
NPY4R	0	broad.mit.edu	37	10	47086901	47086901	+	Missense_Mutation	SNP	G	G	A	rs148605550	byFrequency	TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr10:47086901G>A	ENST00000374312.1	+	3	537	c.118G>A	c.(118-120)Gtg>Atg	p.V40M	NPY4R_ENST00000395716.1_Missense_Mutation_p.V40M	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		TTCCGTGGACGTGATGGTCTT	0.532000													17	76					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123237	81123237	+	Silent	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr4:81123237C>T	ENST00000339711.4	+	10	1852	c.621C>T	c.(619-621)ggC>ggT	p.G207G	PRDM8_ENST00000415738.2_Silent_p.G207G|PRDM8_ENST00000504452.1_Silent_p.G207G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcggcggcggcggtggcaaag	0.657000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	85					0	0	1	0	0
NUDCD2	134492	broad.mit.edu	37	5	162886970	162886970	+	Silent	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr5:162886970G>A	ENST00000302764.4	-	1	176	c.87C>T	c.(85-87)ttC>ttT	p.F29F	NUDCD2_ENST00000517501.1_Silent_p.F29F	NM_145266.4	NP_660309.1	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	29	CS.					intracellular				large_intestine(1)|prostate(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)		GAACTTCAATGAACACCTCCT	0.667000													45	102					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30721796	30721796	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr7:30721796T>C	ENST00000471646.1	-	1	518	c.101A>G	c.(100-102)gAg>gGg	p.E34G	CRHR2_ENST00000341843.4_Intron|CRHR2_ENST00000506074.2_Missense_Mutation_p.E34G|CRHR2_ENST00000348438.4_Intron	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	34					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCGCCTACCCTCGGGGTCCAG	0.741000													4	7					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													3	43					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40321507	40321507	+	Silent	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr17:40321507G>A	ENST00000264661.3	-	9	1910	c.1578C>T	c.(1576-1578)atC>atT	p.I526I	KCNH4_ENST00000607371.1_Silent_p.I526I	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	526					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CGTTGGCGTCGATGCCGCTGT	0.637000													9	25					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334139	56334139	+	Silent	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr12:56334139G>A	ENST00000331886.5	+	11	1294	c.840G>A	c.(838-840)ggG>ggA	p.G280G	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000551156.1_Silent_p.G280G|DGKA_ENST00000394147.1_Silent_p.G280G	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	280					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	GTGAGTCCGGGCGCTGCGACC	0.587000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	57					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167031818	167031818	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr3:167031818T>C	ENST00000392766.2	-	16	1701	c.1361A>G	c.(1360-1362)gAc>gGc	p.D454G	ZBBX_ENST00000392764.1_Missense_Mutation_p.D425G|ZBBX_ENST00000455345.2_Missense_Mutation_p.D454G|ZBBX_ENST00000307529.5_Missense_Mutation_p.D454G|ZBBX_ENST00000392767.2_Missense_Mutation_p.D454G	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	454						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						ATTTAAGAAGTCTCTCTTTCC	0.328000													4	175					0	0	1	0	0
WDSUB1	151525	broad.mit.edu	37	2	160105008	160105008	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr2:160105008C>A	ENST00000409990.3	-	10	1404	c.1148G>T	c.(1147-1149)cGt>cTt	p.R383L	WDSUB1_ENST00000409124.1_Intron|WDSUB1_ENST00000392796.3_Missense_Mutation_p.R383L|WDSUB1_ENST00000359774.4_Missense_Mutation_p.R383L|WDSUB1_ENST00000358147.4_Missense_Mutation_p.R291L	NM_001128213.1	NP_001121685.1	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain containing 1	383	SAM.					ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|prostate(1)|stomach(3)	16						CACTTTACTACGCAGTCCTAG	0.363000													3	49					1	1	1	1	0
ABCC12	94160	broad.mit.edu	37	16	48158140	48158140	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr16:48158140G>T	ENST00000311303.3	-	10	1916	c.1571C>A	c.(1570-1572)gCa>gAa	p.A524E	ABCC12_ENST00000416054.1_Missense_Mutation_p.A524E|ABCC12_ENST00000448542.1_Missense_Mutation_p.A524E	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	524	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TAGGAGAGCTGCAAGGAGGGA	0.517000													4	124					2.56e-06	2.66039e-06	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186105941	186105941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr1:186105941G>A	ENST00000271588.4	+	87	13683	c.13454G>A	c.(13453-13455)cGg>cAg	p.R4485Q	HMCN1_ENST00000367492.2_Missense_Mutation_p.R4485Q	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4485	Ig-like C2-type 44.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGGGATGACCGGGTTAACGTG	0.433000													13	36					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233377	43233377	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr19:43233377T>A	ENST00000327495.5	-	5	1325	c.1141A>T	c.(1141-1143)Atc>Ttc	p.I381F	PSG3_ENST00000595140.1_Missense_Mutation_p.I381F	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	381	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				ATCTGGGGGATAAAGAGCTTT	0.458000													17	188					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86838595	86838595	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr15:86838595C>T	ENST00000441037.2	+	16	2287	c.2192C>T	c.(2191-2193)aCg>aTg	p.T731M	AGBL1_ENST00000421325.2_Missense_Mutation_p.T731M|AGBL1_ENST00000389298.3_Missense_Mutation_p.T462M	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	731					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GTGACCATCACGGCCATGCCT	0.498000													32	46					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230323	147230323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr1:147230323G>A	ENST00000271348.2	-	2	1185	c.1024C>T	c.(1024-1026)Cga>Tga	p.R342*	RP11-433J22.2_ENST00000428911.1_RNA|GJA5_ENST00000369237.1_Nonsense_Mutation_p.R342*	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	342					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTAAGACGTCGCTTGTCACTA	0.547000													19	46					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38343641	38343641	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr10:38343641A>G	ENST00000374618.3	+	5	767	c.589A>G	c.(589-591)Agg>Ggg	p.R197G	ZNF33A_ENST00000458705.2_Missense_Mutation_p.R196G|ZNF33A_ENST00000307441.9_Missense_Mutation_p.R196G|ZNF33A_ENST00000432900.2_Missense_Mutation_p.R203G|ZNF33A_ENST00000469037.2_Intron	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	196						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						TTTGAAAAATAGGAACACACT	0.343000													21	28					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64601793	64601793	+	Missense_Mutation	SNP	C	C	T	rs113699218	byFrequency	TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr3:64601793C>T	ENST00000498707.1	-	20	3209	c.2867G>A	c.(2866-2868)cGc>cAc	p.R956H	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R928H	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	956	TSP type-1 3.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GTCCAATGTGCGGTAACCCAA	0.458000													6	164					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134075498	134075498	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr4:134075498G>A	ENST00000264360.4	+	2	3494	c.2668G>A	c.(2668-2670)Gac>Aac	p.D890N		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	890					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTATCTAGTTGACAGACCTCG	0.373000													13	34					0	0	1	0	0
PEBP4	157310	broad.mit.edu	37	8	22675245	22675245	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr8:22675245C>T	ENST00000256404.6	-	4	353	c.262G>A	c.(262-264)Gca>Aca	p.A88T	PEBP4_ENST00000521284.1_5'UTR	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	88						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		ATATAGGTTGCGCCCTGTAAC	0.493000													3	58					0	0	1	0	0
TRMT10C	54931	broad.mit.edu	37	3	101284665	101284665	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr3:101284665G>T	ENST00000309922.6	+	2	1194	c.1040G>T	c.(1039-1041)gGt>gTt	p.G347V		NM_017819.2	NP_060289.2			tRNA methyltransferase 10 homolog C (S. cerevisiae)																		TGGGAAATTGGTAACAAAAAT	0.393000													14	15					3.27435e-08	3.47081e-08	1	1	0
MICAL3	57553	broad.mit.edu	37	22	18368694	18368694	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr22:18368694C>T	ENST00000441493.2	-	16	2543	c.2191G>A	c.(2191-2193)Gcc>Acc	p.A731T	MICAL3_ENST00000429452.1_Missense_Mutation_p.A731T|MICAL3_ENST00000383094.3_Missense_Mutation_p.A731T|MICAL3_ENST00000400561.2_Missense_Mutation_p.A731T|MICAL3_ENST00000414725.2_Missense_Mutation_p.A731T|MICAL3_ENST00000207726.7_Missense_Mutation_p.A731T|MICAL3_ENST00000585038.1_Missense_Mutation_p.A731T|MICAL3_ENST00000444520.1_Missense_Mutation_p.A731T	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	731						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		TCAAATTTGGCCAGCAGCTGG	0.557000													4	106					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	31355278	31355278	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr17:31355278G>A	ENST00000225823.2	-	4	1992	c.1120C>T	c.(1120-1122)Cgc>Tgc	p.R374C	ASIC2_ENST00000359872.6_Missense_Mutation_p.R323C|ASIC2_ENST00000448983.1_5'UTR	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	323					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	TGAACCATGCGGCAGTTGCAG	0.557000													7	25					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52548185	52548185	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr3:52548185C>T	ENST00000321725.6	+	33	3578	c.3502C>T	c.(3502-3504)Ccc>Tcc	p.P1168S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1168	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CATCTTTGTGCCCACCAACCG	0.622000													4	45					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296438	29296438	+	Silent	SNP	G	G	A			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr2:29296438G>A	ENST00000331664.5	-	1	689	c.690C>T	c.(688-690)agC>agT	p.S230S		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	230					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCAACAGCTGGCTGATCTCCT	0.557000													24	57					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947268	237947268	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr1:237947268C>T	ENST00000366574.2	+	90	12573	c.12256C>T	c.(12256-12258)Cgc>Tgc	p.R4086C	RYR2_ENST00000542537.1_Missense_Mutation_p.R4070C|RYR2_ENST00000360064.6_Missense_Mutation_p.R4092C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4086					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTCGTCAAACGCTTCCACGA	0.507000													12	17					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142567247	142567247	+	Missense_Mutation	SNP	C	C	T	rs144482227		TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr3:142567247C>T	ENST00000295992.3	-	3	566	c.260G>A	c.(259-261)cGc>cAc	p.R87H	PCOLCE2_ENST00000485766.1_Missense_Mutation_p.R87H	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	87	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity	p.R87H(2)		NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						AAAGTCATAGCGGCACAGGTT	0.517000													4	109					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62761339	62761339	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr11:62761339C>T	ENST00000336232.2	-	9	1363	c.1228G>A	c.(1228-1230)Gtg>Atg	p.V410M	SLC22A8_ENST00000535878.1_Missense_Mutation_p.V287M|SLC22A8_ENST00000311438.8_Missense_Mutation_p.V410M|SLC22A8_ENST00000545207.1_Missense_Mutation_p.V319M|SLC22A8_ENST00000430500.2_Missense_Mutation_p.V410M	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	410					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						ACTGTCCTCACGGTCTGCAAG	0.498000													3	53					0	0	1	0	0
EVI2B	2124	broad.mit.edu	37	17	29632323	29632323	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr17:29632323A>G	ENST00000330927.4	-	2	459	c.305T>C	c.(304-306)cTt>cCt	p.L102P	CTD-2370N5.3_ENST00000578584.1_3'UTR|EVI2B_ENST00000544462.1_Missense_Mutation_p.L117P|EVI2B_ENST00000577894.1_Missense_Mutation_p.L102P|NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron	NM_006495.3	NP_006486.3	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	102						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GTTGTAGGCAAGTGGTTGTCC	0.493000													48	92					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56386857	56386857	+	Silent	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr15:56386857C>T	ENST00000423270.1	-	9	3068	c.3069G>A	c.(3067-3069)ccG>ccA	p.P1023P	RFX7_ENST00000317318.6_Silent_p.P1023P|RFX7_ENST00000559447.2_Silent_p.P926P|RFX7_ENST00000422057.1_Silent_p.P926P	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	926					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TGAATGCAAACGGATTCCTGC	0.498000													13	29					0	0	1	0	0
SBSPON	157869	broad.mit.edu	37	8	73979646	73979646	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr8:73979646C>T	ENST00000297354.6	-	5	929	c.725G>A	c.(724-726)gGa>gAa	p.G242E	SBSPON_ENST00000519697.1_5'UTR	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	242					immune response	extracellular region	polysaccharide binding|scavenger receptor activity										TTTCCAAGTTCCTTGACACCG	0.368000													50	38					0	0	1	0	0
HIST1H2BE	8344	broad.mit.edu	37	6	26184299	26184299	+	Silent	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr6:26184299C>T	ENST00000356530.3	+	1	342	c.276C>T	c.(274-276)tcC>tcT	p.S92S		NM_003523.2	NP_003514.2	P62807	H2B1C_HUMAN	histone cluster 1, H2be	92					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(1)	4						CCATCACCTCCAGGGAGATCC	0.617000													4	88					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19194989	19194989	+	Silent	SNP	C	C	T			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr16:19194989C>T	ENST00000562034.1	+	3	4086	c.288C>T	c.(286-288)ttC>ttT	p.F96F	SYT17_ENST00000355377.2_Silent_p.F157F|SYT17_ENST00000562711.2_Silent_p.F153F|SYT17_ENST00000568115.1_Silent_p.F96F			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	157						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TCAGGAAGTTCGAACCCCACC	0.547000													3	46					0	0	1	0	0
RNPC3	55599	broad.mit.edu	37	1	104094378	104094378	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr1:104094378delT	ENST00000533099.1	+	15	1766	c.1530delT	c.(1528-1530)ccfs	p.P510fs	RNPC3_ENST00000524631.1_Frame_Shift_Del_p.P509fs|RNPC3_ENST00000423855.2_Frame_Shift_Del_p.P510fs			Q96LT9	RBM40_HUMAN	RNA-binding region (RNP1, RRM) containing 3	510					mRNA processing	U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Lung(183;0.111)|Epithelial(280;0.122)|all cancers(265;0.125)|Colorectal(144;0.163)		AACAAGATCCTAAGGAAGGAA	0.254													2	4	---	---	---	---					
PLEC	5339	broad.mit.edu	37	8	144992095	144992096	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr8:144992095_144992096insTA	ENST00000322810.4	-	32	12473_12474	c.12304_12305insTA	c.(12304-12306)gctfs	p.A4102fs	PLEC_ENST00000527096.1_Frame_Shift_Ins_p.A3988fs|PLEC_ENST00000345136.3_Frame_Shift_Ins_p.A3965fs|PLEC_ENST00000354958.2_Frame_Shift_Ins_p.A3943fs|PLEC_ENST00000357649.2_Frame_Shift_Ins_p.A3969fs|PLEC_ENST00000436759.2_Frame_Shift_Ins_p.A3992fs|PLEC_ENST00000356346.3_Frame_Shift_Ins_p.A3951fs|PLEC_ENST00000398774.2_Frame_Shift_Ins_p.A3933fs|PLEC_ENST00000354589.3_Frame_Shift_Ins_p.A3965fs	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4102	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CTCCAGGAGCTCAAAGGCTGTG	0.639													8	30	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134054795	134054797	+	Splice_Site	DEL	CAC	CAC	-			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr11:134054795_134054797delCAC	ENST00000534548.2	-	18	2400		c.e18+1		RP11-700F16.3_ENST00000531710.1_RNA	NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		AGCAGACACTCACCAGTCACTTT	0.438													119	246	---	---	---	---					
NFATC4	4776	broad.mit.edu	37	14	24837630	24837630	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr14:24837630delG	ENST00000413692.2	+	2	417	c.273delG	c.(271-273)gcfs	p.A91fs	NFATC4_ENST00000250373.4_Frame_Shift_Del_p.A28fs|NFATC4_ENST00000424781.2_Frame_Shift_Del_p.A41fs|NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000556279.1_Frame_Shift_Del_p.A60fs|NFATC4_ENST00000555590.1_Frame_Shift_Del_p.A41fs|NFATC4_ENST00000554966.1_Frame_Shift_Del_p.A41fs|NFATC4_ENST00000553469.1_Frame_Shift_Del_p.A60fs|NFATC4_ENST00000554050.1_Frame_Shift_Del_p.A28fs|NFATC4_ENST00000539237.2_Frame_Shift_Del_p.A60fs|NFATC4_ENST00000553708.1_Frame_Shift_Del_p.A28fs|NFATC4_ENST00000554591.1_Frame_Shift_Del_p.A91fs	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	28	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CGCTGGGCGCGGGGGGATTGG	0.657													2	4	---	---	---	---					
GATA6	2627	broad.mit.edu	37	18	19752073	19752075	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chr18:19752073_19752075delACC	ENST00000269216.3	+	2	1245_1247	c.968_970delACC	c.(967-972)tac>t	p.YH323del	GATA6_ENST00000581694.1_In_Frame_Del_p.YH323del	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	323					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			AACGGGACGTaccaccaccacca	0.749													3	5	---	---	---	---					
TBL1X	6907	broad.mit.edu	37	X	9656280	9656280	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAJT-01A-11D-A41K-08	TCGA-XK-AAJT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21e0de1c-8cdc-4b26-ba3f-e13f863af312	8d1a3e2a-d051-4c36-89a2-dcf617cc1ea3	g.chrX:9656280delC	ENST00000217964.7	+	7	1221	c.581delC	c.(580-582)agfs	p.T194fs	TBL1X_ENST00000536365.1_Frame_Shift_Del_p.T143fs|TBL1X_ENST00000407597.2_Frame_Shift_Del_p.T194fs|TBL1X_ENST00000380961.1_Frame_Shift_Del_p.T143fs|TBL1X_ENST00000424279.1_Frame_Shift_Del_p.T143fs	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	194					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				AGAGAGGCCACGGTGAATGGG	0.612													2	4	---	---	---	---