Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								3	33					0	0	1	0	0
RAD23A	5886	broad.mit.edu	37	19	13059566	13059566	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr19:13059566T>C	ENST00000586534.1	+	5	600	c.539T>C	c.(538-540)gTc>gCc	p.V180A	RAD23A_ENST00000541222.1_Missense_Mutation_p.V15A|RAD23A_ENST00000588826.2_3'UTR|RAD23A_ENST00000316856.3_Missense_Mutation_p.V180A|RAD23A_ENST00000592268.1_Missense_Mutation_p.V180A			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	180	UBA 1.				interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						CGAGAGCGGGTCGTGGCCGCC	0.632000								Nucleotide excision repair (NER)					5	123					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147113841	147113841	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr3:147113841G>C	ENST00000383075.3	-	3	998	c.486C>G	c.(484-486)caC>caG	p.H162Q	ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000425731.3_Missense_Mutation_p.H200Q|ZIC4_ENST00000484399.1_Missense_Mutation_p.H162Q|ZIC4_ENST00000525172.2_Missense_Mutation_p.H212Q|ZIC4_ENST00000473123.1_Missense_Mutation_p.H162Q	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	162						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GGCCGCCGACGTGCTCCACGG	0.602000													5	100					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7578728	7578728	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr6:7578728T>C	ENST00000379802.3	+	22	3358	c.3017T>C	c.(3016-3018)cTa>cCa	p.L1006P	DSP_ENST00000418664.2_Missense_Mutation_p.L1006P	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1006	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TACATTGAACTACTTACAAGA	0.358000													4	52					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3297232	3297232	+	Silent	SNP	C	C	T			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr16:3297232C>T	ENST00000219596.1	-	5	1410	c.1371G>A	c.(1369-1371)gcG>gcA	p.A457A	MEFV_ENST00000541159.1_Silent_p.A246A|MEFV_ENST00000536379.1_Silent_p.A246A|MEFV_ENST00000339854.4_Silent_p.A277A	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	457					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GCTGCTTCAGCGCTTCAGTTT	0.597000													6	74					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37343159	37343159	+	Missense_Mutation	SNP	G	G	C	rs149496070		TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr17:37343159G>C	ENST00000394303.3	-	5	645	c.438C>G	c.(436-438)atC>atG	p.I146M	CACNB1_ENST00000344140.5_Missense_Mutation_p.I146M|CACNB1_ENST00000394310.3_Missense_Mutation_p.I146M|CACNB1_ENST00000582877.1_5'UTR	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	146	SH3.				axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCAGCCGCCCGATCCACCAGT	0.562000													3	38					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157509002	157509002	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr1:157509002C>T	ENST00000361835.3	-	7	1433	c.1276G>A	c.(1276-1278)Gcc>Acc	p.A426T	FCRL5_ENST00000368189.3_Missense_Mutation_p.A426T|FCRL5_ENST00000356953.4_Missense_Mutation_p.A426T|FCRL5_ENST00000368191.3_Missense_Mutation_p.A341T|FCRL5_ENST00000368190.3_Missense_Mutation_p.A426T	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	426	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCAGAGTTGGCCGACCTACGC	0.572000													3	21					0	0	1	0	0
RP11-69H14.6	0	broad.mit.edu	37	15	22332432	22332432	+	RNA	SNP	C	C	T			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr15:22332432C>T	ENST00000558896.1	+	0	239																											AAGATTCTAACGTGACAGAAC	0.343000													4	136					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977359	29977359	+	RNA	SNP	G	G	A	rs3831361	by1000genomes	TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr6:29977359G>A	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							ATTTGTTCATGCCTTCCCTTT	0.453000													5	35					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149302	34149302	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chrX:34149302G>A	ENST00000346193.3	-	1	1145	c.1094C>T	c.(1093-1095)gCg>gTg	p.A365V		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	365										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CTTGGGAGGCGCTAGGCGGAG	0.627000													3	24					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													5	35					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75068480	75068480	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr7:75068480C>T	ENST00000453279.2	-	6	1114	c.250G>A	c.(250-252)Gga>Aga	p.G84R	POM121C_ENST00000257665.5_Missense_Mutation_p.G326R	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	326	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						GCTGAATGTCCACTGCCACTG	0.453000													6	184					0	0	1	0	0
C15orf59	388135	broad.mit.edu	37	15	74032722	74032722	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr15:74032722G>A	ENST00000569673.1	-	3	1622	c.418C>T	c.(418-420)Cgc>Tgc	p.R140C	C15orf59_ENST00000558834.1_5'UTR|C15orf59_ENST00000379822.4_Missense_Mutation_p.R140C			Q2T9L4	CO059_HUMAN	chromosome 15 open reading frame 59	140										breast(1)|endometrium(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TTCATGAGGCGGTAGTCAGGG	0.647000													3	63					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100594119	100594119	+	Silent	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr15:100594119G>A	ENST00000268070.4	-	16	2383	c.2278C>T	c.(2278-2280)Cta>Tta	p.L760L		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	760	Spacer.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		TGCAGCGGTAGTTTGGTTGGT	0.527000													6	206					0	0	1	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238615	71238615	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr11:71238615G>A	ENST00000398536.4	+	1	303	c.269G>A	c.(268-270)tGt>tAt	p.C90Y		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	90	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						TGTGGTTCTTGTGgctgctcc	0.647000													6	135					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96523162	96523162	+	Silent	SNP	G	G	T			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr2:96523162G>T	ENST00000456556.1	-	62	4059	c.3975C>A	c.(3973-3975)atC>atA	p.I1325I	ANKRD36C_ENST00000420871.2_Silent_p.I576I|ANKRD36C_ENST00000419039.2_Silent_p.I352I					ankyrin repeat domain 36C									p.I1325I(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GCTCTTCTGTGATTCTTAACT	0.343000													3	14					0.115264	0.115264	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46279833	46279833	+	Silent	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr20:46279833G>A	ENST00000372004.3	+	20	3963	c.3747G>A	c.(3745-3747)caG>caA	p.Q1249Q	NCOA3_ENST00000371997.3_Silent_p.Q1244Q|NCOA3_ENST00000371998.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1179Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1253	Acetyltransferase.|Poly-Gln.		Missing.		androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcaacagcagc	0.547000													3	38					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10894418	10894418	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr6:10894418G>A	ENST00000283141.6	+	4	613	c.317G>A	c.(316-318)cGg>cAg	p.R106Q	SYCP2L_ENST00000543878.1_5'UTR|RP11-637O19.3_ENST00000480294.1_3'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	106						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			CTGCTAATTCGGCAGGGACTG	0.378000													6	96					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731451	21731451	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr17:21731451G>A	ENST00000578713.1	+	2	530	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584755.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TGACACCATCGAAAATGTGAA	0.542000													3	48					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76212096	76212096	+	Nonsense_Mutation	SNP	C	C	T	rs147848202		TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr17:76212096C>T	ENST00000301633.4	+	3	402	c.271C>T	c.(271-273)Cga>Tga	p.R91*	BIRC5_ENST00000350051.3_Intron|AC087645.1_ENST00000600484.1_Intron|BIRC5_ENST00000592734.1_Intron|BIRC5_ENST00000374948.2_Intron	NM_001012271.1	NP_001012271.1	O15392	BIRC5_HUMAN	baculoviral IAP repeat containing 5	74					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			tttgggaggccgaggcgggcg	0.562000													3	27					0	0	1	0	0
RP11-343N15.1	0	broad.mit.edu	37	1	121137791	121137796	+	RNA	DEL	CCACCG	CCACCG	-	rs28552466	by1000genomes	TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr1:121137791_121137796delCCACCG	ENST00000437515.1	-	0	329																											ATTTCGCCCTCCACCGCCGCCGCCAC	0.631													3	6	---	---	---	---					
RP11-584P21.2	0	broad.mit.edu	37	4	68311853	68311855	+	RNA	DEL	GAG	GAG	-			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr4:68311853_68311855delGAG	ENST00000502400.1	-	0	34																											TCTCTATGGCGAGGAGGAGGAGG	0.547													2	4	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)del	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													5	5	---	---	---	---					
C1QTNF8	390664	broad.mit.edu	37	16	1143978	1143979	+	Frame_Shift_Ins	INS	-	-	C	rs142667444	by1000genomes	TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr16:1143978_1143979insC	ENST00000328449.5	-	4	554_555	c.281_282insG	c.(280-282)gctfs	p.A94fs		NM_207419.3	NP_997302.2	P60827	C1QT8_HUMAN	C1q and tumor necrosis factor related protein 8	94	Collagen-like.					collagen				lung(2)|prostate(1)|skin(1)	4		Hepatocellular(780;0.00369)				GGCCCTGCAGGCCCCGGGCGCC	0.767													3	5	---	---	---	---					
SBF1	6305	broad.mit.edu	37	22	50905121	50905121	+	Frame_Shift_Del	DEL	C	C	-			TCGA-V1-A8MK-01A-11D-A364-08	TCGA-V1-A8MK-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96303eed-b939-4980-b0c6-c64f4c0c6bf1	7f00368f-9274-4a6d-a253-193feaac3ced	g.chr22:50905121delC	ENST00000380817.2	-	6	751	c.568delG	c.(568-570)ctfs	p.A190fs	SBF1_ENST00000348911.6_Frame_Shift_Del_p.A191fs|SBF1_ENST00000390679.3_Frame_Shift_Del_p.A190fs	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	190	DENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGTCACCAGCCCCCAAAGAG	0.637													2	4	---	---	---	---