Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYT11	23208	broad.mit.edu	37	1	155837993	155837993	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr1:155837993G>A	ENST00000368324.4	+	2	525	c.272G>A	c.(271-273)cGt>cAt	p.R91H	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	91						cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GAAGGTGGACGTAGGAACCTG	0.522000													8	69					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196581641	196581641	+	Silent	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr2:196581641C>T	ENST00000409086.3	+	7	2252	c.1977C>T	c.(1975-1977)tcC>tcT	p.S659S	SLC39A10_ENST00000359634.5_Silent_p.S659S|SLC39A10_ENST00000541054.1_Silent_p.S209S	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	659					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			ATTCTGGATCCGATCTGAAAG	0.488000													17	68					0	0	1	0	0
TUBBP5	0	broad.mit.edu	37	9	141070116	141070116	+	RNA	SNP	G	G	A	rs142836124	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr9:141070116G>A	ENST00000503395.1	+	0	1196																		p.R77H(1)									GACTCTGTGCGCTCGGGGCCC	0.687000													4	66					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825278	74825278	+	Missense_Mutation	SNP	G	G	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr14:74825278G>T	ENST00000256362.4	+	2	2033	c.1792G>T	c.(1792-1794)Gat>Tat	p.D598Y		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	598					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TTCTTCAGAAGATGTAGAGGG	0.662000													11	28					0.010729	0.0111339	1	1	0
COL4A6	1288	broad.mit.edu	37	X	107423790	107423790	+	Missense_Mutation	SNP	C	C	G			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chrX:107423790C>G	ENST00000334504.7	-	25	2319	c.2086G>C	c.(2086-2088)Gga>Cga	p.G696R	COL4A6_ENST00000394872.2_Missense_Mutation_p.G697R|COL4A6_ENST00000545689.1_Missense_Mutation_p.G696R|COL4A6_ENST00000372216.4_Missense_Mutation_p.G697R|COL4A6_ENST00000538570.1_Missense_Mutation_p.G696R	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	697	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CCTGGCTCTCCTTTACTTCCA	0.517000									Alport syndrome with Diffuse Leiomyomatosis				3	36					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134084436	134084436	+	Splice_Site	SNP	G	G	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr4:134084436G>T	ENST00000264360.4	+	4	3928	c.3103_splice	c.e4+1	p.L1034_splice		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	1034					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CACCATATTTGAGTAAGTATT	0.433000													20	37					5.35267e-07	6.13326e-07	1	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274415	39274415	+	Silent	SNP	C	C	T	rs425487	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:39274415C>T	ENST00000391413.2	-	1	191	c.153G>A	c.(151-153)agG>agA	p.R51R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.R51R(6)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCACTGGGGCCTGCAGCAGC	0.667000													4	52					0	0	1	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37304308	37304308	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr9:37304308C>T	ENST00000336755.5	+	4	884	c.778C>T	c.(778-780)Cga>Tga	p.R260*	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000534928.1_5'UTR	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	260							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		CCCCTTACCACGAGTACGTGA	0.438000													19	73					0	0	1	0	0
TUBBP1	0	broad.mit.edu	37	8	30210703	30210703	+	RNA	SNP	T	T	G			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr8:30210703T>G	ENST00000518096.1	+	0	1315																											CCGGAAGGCCTTCCTCCACTG	0.572000													10	54					0	0	1	0	0
TRBV6-7	0	broad.mit.edu	37	7	142143906	142143906	+	RNA	SNP	G	G	C	rs146728507	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:142143906G>C	ENST00000390373.2	-	0	89																											TCTTCAGGACGTGGAATTTTG	0.527000													5	91					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803618	185803618	+	Silent	SNP	T	T	G			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr2:185803618T>G	ENST00000302277.6	+	4	4089	c.3495T>G	c.(3493-3495)gcT>gcG	p.A1165A		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1165						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CTTTTGTTGCTCCTCCTCAGA	0.512000													32	87					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11827215	11827215	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:11827215C>T	ENST00000262442.3	+	62	11902	c.11834C>T	c.(11833-11835)gCg>gTg	p.A3945V	DNAH9_ENST00000454412.2_Missense_Mutation_p.A3945V|DNAH9_ENST00000396001.2_Missense_Mutation_p.A257V	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3945	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCTGAGGCTGCGCTGGACCTC	0.493000													25	83					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85213927	85213927	+	Missense_Mutation	SNP	C	C	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chrX:85213927C>A	ENST00000357749.2	-	6	787	c.758G>T	c.(757-759)cGa>cTa	p.R253L	CHM_ENST00000537751.1_Missense_Mutation_p.R105L|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	253					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				CTCTGCATATCGACTAACATT	0.343000													17	10					5.3912e-06	6.05135e-06	1	1	0
TRBV5-4	0	broad.mit.edu	37	7	142168890	142168890	+	RNA	SNP	C	C	T	rs143671051	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:142168890C>T	ENST00000454561.2	-	0	155																											GGGCTTGGTCCTCCTGGGGAA	0.592000													4	20					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113515329	113515329	+	Silent	SNP	C	C	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr12:113515329C>A	ENST00000257600.3	+	2	863	c.360C>A	c.(358-360)gcC>gcA	p.A120A		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	120	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding	p.A120A(3)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CATGGACGGCCTACGATATGG	0.627000													5	51					1	1	1	1	0
TCF20	6942	broad.mit.edu	37	22	42605932	42605932	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr22:42605932C>T	ENST00000359486.3	-	1	5516	c.5380G>A	c.(5380-5382)Gac>Aac	p.D1794N	TCF20_ENST00000335626.4_Missense_Mutation_p.D1794N|TCF20_ENST00000404876.1_Missense_Mutation_p.D95N	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1794					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CCACCACAGTCTTCCGAGCGG	0.607000													33	65					0	0	1	0	0
KRTAP9-3	83900	broad.mit.edu	37	17	39389179	39389179	+	Silent	SNP	C	C	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:39389179C>A	ENST00000411528.2	+	1	465	c.426C>A	c.(424-426)acC>acA	p.T142T		NM_031962.2	NP_114168.1	Q9BYQ3	KRA93_HUMAN	keratin associated protein 9-3	142	16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]- [TASPI].					keratin filament	protein binding			breast(1)|endometrium(3)|lung(2)|ovary(1)|prostate(1)	8		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCTGCAGGACCACTTGTTTCC	0.567000													4	148					3.59834e-05	3.88056e-05	1	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18195549	18195549	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr11:18195549T>C	ENST00000314254.3	+	1	1166	c.746T>C	c.(745-747)tTa>tCa	p.L249S	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	249						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TTGGAAGTCTTATATTGTCAT	0.502000													25	50					0	0	1	0	0
TMEM106B	54664	broad.mit.edu	37	7	12270040	12270040	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:12270040T>C	ENST00000396667.2	+	7	930	c.608T>C	c.(607-609)aTa>aCa	p.I203T	TMEM106B_ENST00000396668.3_Missense_Mutation_p.I203T	NM_018374.3	NP_060844.2	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	203						integral to membrane				NS(1)|endometrium(8)|large_intestine(2)|lung(7)	18				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		CCTACCGTTATAGCAGAGGAA	0.274000													16	58					0	0	1	0	0
APH1B	83464	broad.mit.edu	37	15	63569916	63569916	+	Missense_Mutation	SNP	A	A	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr15:63569916A>T	ENST00000261879.5	+	1	164	c.94A>T	c.(94-96)Atc>Ttc	p.I32F	APH1B_ENST00000380343.4_Missense_Mutation_p.I32F	NM_001145646.1|NM_031301.3	NP_001139118.1|NP_112591.2	Q8WW43	APH1B_HUMAN	APH1B gamma secretase subunit	32					apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	integral to membrane|plasma membrane|transport vesicle	peptidase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	12						GCCGTTGCGTATCATCTTCCT	0.692000													27	53					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	20					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53512168	53512168	+	Silent	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr12:53512168C>T	ENST00000301466.3	+	8	873	c.813C>T	c.(811-813)taC>taT	p.Y271Y		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	271					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						TCTCCAGCTACCTCTACTTCC	0.572000													15	51					0	0	1	0	0
CHRM5	0	broad.mit.edu	37	15	34355863	34355863	+	Silent	SNP	C	C	T	rs151106804		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr15:34355863C>T	ENST00000383263.5	+	3	1615	c.945C>T	c.(943-945)ccC>ccT	p.P315P	CHRM5_ENST00000557872.1_Silent_p.P315P	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	315					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	AGGACAAGCCCGCCACTGACC	0.552000													12	41					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397652	125397652	+	Silent	SNP	T	T	C	rs146795524		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr12:125397652T>C	ENST00000536769.1	-	1	2242	c.666A>G	c.(664-666)gtA>gtG	p.V222V	UBC_ENST00000339647.5_Silent_p.V222V|UBC_ENST00000546120.1_Silent_p.V146V|UBC_ENST00000538617.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	222	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGACGGAGTACCAGGTGCA	0.512000													4	97					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38645123	38645123	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:38645123G>A	ENST00000254051.6	-	3	696	c.538C>T	c.(538-540)Cgc>Tgc	p.R180C		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	180	Ser-rich.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCACCACTGCGAAGGGAGCCG	0.632000													28	92					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73745591	73745591	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chrX:73745591T>C	ENST00000276033.5	+	4	1421	c.1255T>C	c.(1255-1257)Tat>Cat	p.Y419H	SLC16A2_ENST00000587091.1_Missense_Mutation_p.Y345H			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	345						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	TCAGATGAAGTATGTGGAGGA	0.507000													23	26					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43438030	43438030	+	Silent	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr18:43438030G>A	ENST00000282041.5	-	42	7264	c.7230C>T	c.(7228-7230)tcC>tcT	p.S2410S	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2410					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						CTTCCTCCACGGAGCTAGGGG	0.468000													3	22					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75875623	75875623	+	Missense_Mutation	SNP	C	C	G			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr12:75875623C>G	ENST00000266659.3	+	2	385	c.184C>G	c.(184-186)Cca>Gca	p.P62A		NM_006851.2	NP_006842.2	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1	62					cellular lipid metabolic process	extracellular region|integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	14						GACTTGGGACCCAGCACTAGC	0.453000													29	131					0	0	1	0	0
TRBV6-7	0	broad.mit.edu	37	7	142143907	142143907	+	RNA	SNP	T	T	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:142143907T>C	ENST00000390373.2	-	0	88																											CTTCAGGACGTGGAATTTTGG	0.527000													5	92					0	0	1	0	0
TRBV5-4	0	broad.mit.edu	37	7	142168862	142168862	+	RNA	SNP	A	A	G	rs140095394	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:142168862A>G	ENST00000454561.2	-	0	183																											TGGGCCAGGCAGCACTGCACC	0.597000													4	22					0	0	1	0	0
SLC43A2	124935	broad.mit.edu	37	17	1486509	1486509	+	Missense_Mutation	SNP	G	G	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:1486509G>C	ENST00000571650.1	-	12	1657	c.1351C>G	c.(1351-1353)Ctg>Gtg	p.L451V	SLC43A2_ENST00000301335.4_Missense_Mutation_p.L447V|SLC43A2_ENST00000382147.4_Missense_Mutation_p.L451V|SLC43A2_ENST00000412517.3_Missense_Mutation_p.L310V			Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2	447					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TGGAGAGGCAGGTTGGGAATG	0.577000													15	39					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													5	77					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16953672	16953672	+	RNA	SNP	C	C	T	rs3738597	by1000genomes	TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr1:16953672C>T	ENST00000412962.1	-	0	589																											TCGGTCTTCTCGGCCTGCAGC	0.652000													5	45					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	42					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11512789	11512789	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:11512789C>T	ENST00000380456.3	-	13	1445	c.1382G>A	c.(1381-1383)cGc>cAc	p.R461H	RGL3_ENST00000393423.3_Missense_Mutation_p.R461H	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	461	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						CTGCTGGATGCGGGCCAGGAT	0.667000													11	16					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77635895	77635895	+	Missense_Mutation	SNP	C	C	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr11:77635895C>A	ENST00000534064.1	-	12	1449	c.1415G>T	c.(1414-1416)tGc>tTc	p.C472F	INTS4_ENST00000529807.1_Missense_Mutation_p.C472F|INTS4_ENST00000525931.1_5'UTR	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	472					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			ATTAGTACAGCATAAGAGTTC	0.383000													3	26					0.004672	0.00494154	1	1	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000354397.6_Missense_Mutation_p.R129W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W|CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000394173.4_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000602261.1_Missense_Mutation_p.R129W|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000394161.5_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													4	202					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235889	23235889	+	Missense_Mutation	SNP	A	A	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr14:23235889A>T	ENST00000285848.5	+	1	159	c.159A>T	c.(157-159)aaA>aaT	p.K53N	OXA1L_ENST00000604262.1_5'UTR	NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CAGGCGCAAAAGCAAGTCCTC	0.592000													34	85					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072229	34072229	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:34072229G>A	ENST00000254466.6	-	6	2314	c.2287C>T	c.(2287-2289)Cgg>Tgg	p.R763W	GAS2L2_ENST00000587565.1_Missense_Mutation_p.R747W	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	763					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTGGGCTTCCGGAGAGTTCTC	0.607000													39	99					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104302620	104302620	+	Missense_Mutation	SNP	T	T	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr9:104302620T>A	ENST00000389120.3	+	3	355	c.265T>A	c.(265-267)Tca>Aca	p.S89T		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	89					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TGATGATGCCTCACTATTGAT	0.423000													4	184					0	0	1	0	0
ZNF398	0	broad.mit.edu	37	7	148873589	148873589	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr7:148873589T>C	ENST00000420008.2	+	5	966	c.178T>C	c.(178-180)Tct>Cct	p.S60P	ZNF398_ENST00000491174.1_Missense_Mutation_p.S60P|ZNF398_ENST00000540950.1_Missense_Mutation_p.S236P|ZNF398_ENST00000475153.1_Missense_Mutation_p.S231P|ZNF398_ENST00000335901.4_Missense_Mutation_p.S60P|ZNF398_ENST00000483892.1_Missense_Mutation_p.S60P|ZNF398_ENST00000426851.2_Missense_Mutation_p.S60P	NM_170686.2	NP_733787.1	Q8TD17	ZN398_HUMAN	zinc finger protein 398	231					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			AGATATTCTGTCTTGGATTAA	0.403000													3	38					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													4	48					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29046692	29046692	+	Silent	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr18:29046692C>T	ENST00000257189.4	+	11	1694	c.1611C>T	c.(1609-1611)gcC>gcT	p.A537A		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	537					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTTGCCTGCCGTATGGAGTA	0.413000													16	55					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16973254	16973254	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:16973254G>A	ENST00000379803.1	+	9	1164	c.1150G>A	c.(1150-1152)Ggg>Agg	p.G384R	SIN3B_ENST00000248054.5_Missense_Mutation_p.G384R	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	384	Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATCCGGGGACGGGATAAGCCG	0.542000													14	34					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52568806	52568806	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:52568806G>A	ENST00000389534.4	-	7	2788	c.2329C>T	c.(2329-2331)Cgc>Tgc	p.R777C	ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Missense_Mutation_p.R353C|ZNF841_ENST00000594295.1_Missense_Mutation_p.R777C|ZNF841_ENST00000426391.2_Missense_Mutation_p.R661C	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						AGGCCTGAGCGATAACGGAAG	0.428000													3	32					0	0	1	0	0
PHYH	5264	broad.mit.edu	37	10	13336427	13336427	+	Splice_Site	SNP	C	C	T			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr10:13336427C>T	ENST00000396920.3	-	4	762		c.e4+1		PHYH_ENST00000396913.2_Splice_Site|PHYH_ENST00000263038.4_Splice_Site			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase						fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TGGTCTCTGACCTCGGGGAGA	0.507000													9	29					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													3	5	---	---	---	---					
CARHSP1	23589	broad.mit.edu	37	16	8949166	8949169	+	Frame_Shift_Del	DEL	ACAT	ACAT	-			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr16:8949166_8949169delACAT	ENST00000396593.2	-	4	655_658	c.296_299delATGT	c.(295-300)tcfs	p.YV99fs	RP11-77H9.2_ENST00000565934.1_RNA|CARHSP1_ENST00000561530.1_Frame_Shift_Del_p.YV99fs|CARHSP1_ENST00000311052.5_Frame_Shift_Del_p.YV99fs|CARHSP1_ENST00000567554.1_Frame_Shift_Del_p.YV99fs	NM_001042476.1|NM_001278260.1|NM_001278261.1|NM_001278262.1|NM_001278263.1|NM_001278264.1|NM_001278265.1|NM_001278266.1|NM_014316.3	NP_001035941.1|NP_001265189.1|NP_001265190.1|NP_001265191.1|NP_001265192.1|NP_001265193.1|NP_001265194.1|NP_001265195.1|NP_055131.2	Q9Y2V2	CHSP1_HUMAN	calcium regulated heat stable protein 1, 24kDa	99	CSD.				intracellular signal transduction|regulation of mRNA stability|regulation of transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|P granule	DNA binding|mRNA 3'-UTR binding|phosphatase binding			endometrium(2)|lung(1)	3						TTCCACTGGGACATACTCCCCTTC	0.569													7	32	---	---	---	---					
CCDC144B	0	broad.mit.edu	37	17	18498497	18498498	+	RNA	INS	-	-	A	rs72195768		TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr17:18498497_18498498insA	ENST00000442583.1	-	0	749																				NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(6)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	36						CTGCAGGCCTGAAAAAAAAAAA	0.243													2	4	---	---	---	---					
MYH14	79784	broad.mit.edu	37	19	50762446	50762446	+	Frame_Shift_Del	DEL	A	A	-			TCGA-TP-A8TT-01A-12D-A41K-08	TCGA-TP-A8TT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c79fa3-a242-4536-90de-33daeb65c445	34b3bfff-3049-4177-99a4-9ac6332a5ce9	g.chr19:50762446delA	ENST00000440075.2	+	19	2325	c.2278delA	c.(2278-2280)acfs	p.N760fs	MYH14_ENST00000376970.2_Frame_Shift_Del_p.N752fs|MYH14_ENST00000601313.1_Frame_Shift_Del_p.N760fs|MYH14_ENST00000598205.1_Frame_Shift_Del_p.N727fs|MYH14_ENST00000596571.1_Frame_Shift_Del_p.N719fs|MYH14_ENST00000425460.1_Frame_Shift_Del_p.N727fs|MYH14_ENST00000262269.8_Frame_Shift_Del_p.N760fs			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	719	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCTTCGCTGCAACGGGGTCCT	0.711													2	4	---	---	---	---