Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CNNM2	54805	broad.mit.edu	37	10	104678762	104678762	+	Silent	SNP	C	C	T			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr10:104678762C>T	ENST00000369878.3	+	1	649	c.525C>T	c.(523-525)atC>atT	p.I175I	CNNM2_ENST00000433628.2_Silent_p.I175I|CNNM2_ENST00000369875.3_Silent_p.I175I	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	175					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TCATCGAGATCGAGATCAAAC	0.637000													6	176					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42453958	42453958	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr15:42453958C>T	ENST00000318006.5	-	24	2636	c.2474G>A	c.(2473-2475)cGg>cAg	p.R825Q	VPS39_ENST00000348544.4_Missense_Mutation_p.R836Q	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	836					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GTGTAAAATCCGCTCTTCCTG	0.517000													7	167					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65686765	65686765	+	Silent	SNP	G	G	A	rs144581941	byFrequency	TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr15:65686765G>A	ENST00000352385.2	-	9	1907	c.1698C>T	c.(1696-1698)taC>taT	p.Y566Y		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	566	Fibronectin type-III 2.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						TTCCCAAACCGTATTCTATCT	0.602000													7	145					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22913059	22913059	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr1:22913059G>A	ENST00000166244.3	+	4	982	c.910G>A	c.(910-912)Gcc>Acc	p.A304T	EPHA8_ENST00000374644.4_Missense_Mutation_p.A304T|EPHA8_ENST00000538803.1_Missense_Mutation_p.A304T	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	304	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.A304T(2)		breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGCTCCAGCCGCCCAAGCCTG	0.657000													3	39					0	0	1	0	0
USP29	0	broad.mit.edu	37	19	57641660	57641660	+	Silent	SNP	T	T	G			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr19:57641660T>G	ENST00000254181.4	+	4	2071	c.1617T>G	c.(1615-1617)tcT>tcG	p.S539S	USP29_ENST00000598197.1_Silent_p.S539S	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	539					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTTATCTTCTTATTGCAATG	0.403000													6	159					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139397709	139397709	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr9:139397709C>T	ENST00000277541.6	-	27	5167	c.5092G>A	c.(5092-5094)Gac>Aac	p.D1698N		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1698					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGGCCACGTCGGTGGCACTC	0.637000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			3	30					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56676544	56676544	+	Missense_Mutation	SNP	G	G	A	rs146894476	byFrequency	TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr17:56676544G>A	ENST00000389934.3	-	14	2279	c.2162C>T	c.(2161-2163)aCg>aTg	p.T721M	TEX14_ENST00000240361.8_Missense_Mutation_p.T727M|TEX14_ENST00000349033.5_Missense_Mutation_p.T721M	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	727						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCCTCAGTCGTGGACATGTT	0.438000													4	214					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150917382	150917382	+	Silent	SNP	C	C	T			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr5:150917382C>T	ENST00000261800.5	-	11	9177	c.9165G>A	c.(9163-9165)gcG>gcA	p.A3055A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3055	Cadherin 27.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.A3055A(1)		NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATTCATGCGCCCCAGGGC	0.458000													3	48					0	0	1	0	0
MYO1E	4643	broad.mit.edu	37	15	59506877	59506877	+	Missense_Mutation	SNP	T	T	A			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr15:59506877T>A	ENST00000288235.4	-	11	1549	c.1150A>T	c.(1150-1152)Att>Ttt	p.I384F		NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	384	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		AGGACGCCAATGTTGTATTCT	0.423000													5	121					0	0	1	0	0
TMEM17	200728	broad.mit.edu	37	2	62728401	62728401	+	Silent	SNP	C	C	T			TCGA-M7-A723-01A-12D-A32B-08	TCGA-M7-A723-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18514ecc-f430-455b-8ee0-b9f5aff63989	d7b480d0-6d85-42ff-9c69-04d1d9fca8f9	g.chr2:62728401C>T	ENST00000335390.5	-	4	751	c.540G>A	c.(538-540)cgG>cgA	p.R180R		NM_198276.2	NP_938017.2	Q86X19	TMM17_HUMAN	transmembrane protein 17	180						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)			TTGCAGAGAGCCGGTCAAAGT	0.428000													4	75					0	0	1	0	0