Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRMPD2	143162	broad.mit.edu	37	10	49430493	49430493	+	Splice_Site	SNP	G	G	T	rs144515014		TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr10:49430493G>T	ENST00000374201.3	-	12	1620	c.1316_splice	c.e12-1	p.H440_splice	FRMPD2_ENST00000305531.3_Splice_Site_p.H416_splice|FRMPD2_ENST00000407470.4_Splice_Site_p.H409_splice	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	440	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GTCAGGCTGTGCCTGGAAAAG	0.498000													3	52					0.115264	0.115264	1	1	0
TTN	7273	broad.mit.edu	37	2	179432010	179432010	+	Silent	SNP	T	T	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr2:179432010T>G	ENST00000589042.1	-	326	79073	c.78849A>C	c.(78847-78849)gtA>gtC	p.V26283V	TTN_ENST00000342175.6_Silent_p.V17410V|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Silent_p.V17343V|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000460472.2_Silent_p.V17218V|TTN_ENST00000591111.1_Silent_p.V24642V|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.V23715V|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24642	Fibronectin type-III 91.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTATCTAATACTTTTACAT	0.403000													4	102					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583287	119583287	+	Silent	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr12:119583287G>A	ENST00000267260.4	+	9	1261	c.873G>A	c.(871-873)acG>acA	p.T291T		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	291	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding	p.T291T(2)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GAAATGACACGTCCTCGCCAC	0.632000													4	7					0	0	1	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114256921	114256921	+	Silent	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr2:114256921C>T	ENST00000306507.5	+	1	261	c.88C>T	c.(88-90)Ctg>Ttg	p.L30L		NM_012184.4	NP_036316.1	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	30					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(2)	26						AATCGATGTCCTGGGAgagga	0.642000													4	90					0	0	1	0	0
ATMIN	23300	broad.mit.edu	37	16	81078137	81078137	+	Silent	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr16:81078137C>T	ENST00000566488.1	+	3	2529	c.1566C>T	c.(1564-1566)ctC>ctT	p.L522L	ATMIN_ENST00000564241.1_Silent_p.L522L|ATMIN_ENST00000539819.1_3'UTR|ATMIN_ENST00000299575.4_Silent_p.L678L			O43313	ATMIN_HUMAN	ATM interactor	678					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						ACTTCTTACTCGCAGATACCT	0.448000													44	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083587	9083587	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr19:9083587G>A	ENST00000397910.4	-	1	8431	c.8228C>T	c.(8227-8229)tCg>tTg	p.S2743L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2743	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S2743L(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACTGTGATCGAACCTTCATA	0.468000													6	73					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846597	7846597	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr11:7846597T>C	ENST00000328375.1	-	1	922	c.923A>G	c.(922-924)aAa>aGa	p.K308R	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGAAAATATTTTTATTCTAAG	0.348000													3	50					0	0	1	0	0
RAC3	5881	broad.mit.edu	37	17	79990859	79990859	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr17:79990859G>A	ENST00000306897.4	+	4	400	c.262G>A	c.(262-264)Gcc>Acc	p.A88T		NM_005052.2	NP_005043.1	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	88					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding			NS(1)|kidney(1)|skin(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGTGAGCCCGGCCTCCTTCGA	0.622000													20	32					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186088390	186088390	+	Silent	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr1:186088390G>A	ENST00000271588.4	+	78	12145	c.11916G>A	c.(11914-11916)gcG>gcA	p.A3972A	HMCN1_ENST00000367492.2_Silent_p.A3972A	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3972	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTAGGAATGCGGCTGGCTCTG	0.398000													46	64					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2843245	2843245	+	Silent	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr20:2843245C>T	ENST00000380445.3	+	12	1164	c.1092C>T	c.(1090-1092)gaC>gaT	p.D364D	VPS16_ENST00000380443.3_Silent_p.D18D|VPS16_ENST00000380469.3_Intron|VPS16_ENST00000481812.2_Intron	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	364					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						AGAAGGCGGACGAGTACCTGC	0.602000													16	14					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824819	54824819	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr20:54824819G>A	ENST00000243911.2	+	1	1032	c.920G>A	c.(919-921)cGc>cAc	p.R307H		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	344					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CTGGAATTGCGCAACACCTTT	0.517000													4	139					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140265373	140265373	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr4:140265373G>A	ENST00000296543.5	+	6	894	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	NAA15_ENST00000398947.1_Missense_Mutation_p.E191K|NAA15_ENST00000480277.2_3'UTR	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	191					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TGAATATAGTGAACTACTCTT	0.333000													19	82					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51165266	51165266	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr19:51165266G>A	ENST00000293441.1	-	23	6460	c.6442C>T	c.(6442-6444)Cgc>Tgc	p.R2148C	SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000359082.3_Missense_Mutation_p.R2139C|SHANK1_ENST00000391813.1_Missense_Mutation_p.R1535C|SHANK1_ENST00000391814.1_Missense_Mutation_p.R2156C	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2148	SAM.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ATGTTCATGCGGTGGCCCACC	0.622000													18	41					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59511849	59511849	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr8:59511849C>G	ENST00000038176.3	-	19	1739	c.1527G>C	c.(1525-1527)tgG>tgC	p.W509C	NSMAF_ENST00000427130.2_Missense_Mutation_p.W540C	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	509	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity	p.W509C(1)|p.W540C(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				TTAGATCAATCCACTCGTGAA	0.373000													4	204					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53809970	53809970	+	Silent	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr3:53809970C>T	ENST00000288139.3	+	36	4438	c.4320C>T	c.(4318-4320)ctC>ctT	p.L1440L	CACNA1D_ENST00000350061.5_Silent_p.L1420L|CACNA1D_ENST00000422281.2_Silent_p.L1405L|CACNA1D_ENST00000540742.1_Silent_p.L312L	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1420	Dihydropyridine binding (By similarity).|Phenylalkylamine binding (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CAGGGAAGCTCTGTGACCCTG	0.493000													50	76					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023240	76023240	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr6:76023240G>A	ENST00000393004.2	-	5	2529	c.2308C>T	c.(2308-2310)Ctc>Ttc	p.L770F	FILIP1_ENST00000237172.7_Missense_Mutation_p.L770F|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000370020.1_Missense_Mutation_p.L671F			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	770										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTCAGATTGAGAACCTCCTGC	0.433000													35	58					0	0	1	0	0
SEC1P	0	broad.mit.edu	37	19	49183691	49183691	+	RNA	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr19:49183691G>A	ENST00000430145.2	+	0	778					NR_004401.2																						GCCACATCCCGGGGCGCTGTG	0.657000													7	10					0	0	1	0	0
ECI2	10455	broad.mit.edu	37	6	4130794	4130794	+	Splice_Site	SNP	C	C	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr6:4130794C>A	ENST00000465828.1	-	4	508	c.222_splice	c.e4-1	p.E75_splice	C6orf201_ENST00000333388.5_3'UTR|ECI2_ENST00000413766.2_5'UTR|ECI2_ENST00000361538.2_Splice_Site_p.E75_splice|C6orf201_ENST00000380175.4_3'UTR|ECI2_ENST00000380118.3_Splice_Site_p.E105_splice|ECI2_ENST00000380125.2_Splice_Site_p.E75_splice			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	105	ACB.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						CTGGCAGCTTCCTGAACGGAC	0.438000													20	35					1.9806e-07	2.0971e-07	1	1	0
PNKP	11284	broad.mit.edu	37	19	50365803	50365803	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr19:50365803C>G	ENST00000322344.3	-	10	1037	c.928G>C	c.(928-930)Gat>Cat	p.D310H	PNKP_ENST00000596014.1_Missense_Mutation_p.D310H|PNKP_ENST00000600573.1_Missense_Mutation_p.D310H|PNKP_ENST00000600910.1_Missense_Mutation_p.D310H	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	310					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		ACCAGGCGATCGGCGCAGGAG	0.687000								Other BER factors					4	5					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103840	53103840	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr7:53103840G>A	ENST00000408890.4	+	1	492	c.476G>A	c.(475-477)cGc>cAc	p.R159H		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	159								p.R159H(1)		endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CAGAGAgcccgccccgcaggc	0.726000													11	7					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39174617	39174617	+	Silent	SNP	A	A	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr3:39174617A>G	ENST00000301819.6	+	20	2838	c.2661A>G	c.(2659-2661)caA>caG	p.Q887Q	TTC21A_ENST00000493856.1_3'UTR|TTC21A_ENST00000431162.2_Silent_p.Q886Q|TTC21A_ENST00000440121.1_Silent_p.Q838Q	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	886							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCCAGAAGCAACTGGCAGCCT	0.502000													12	27					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152711423	152711423	+	Silent	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr6:152711423G>A	ENST00000367255.5	-	53	8770	c.8169C>T	c.(8167-8169)caC>caT	p.H2723H	SYNE1_ENST00000265368.4_Silent_p.H2723H|SYNE1_ENST00000341594.5_Silent_p.H2762H|SYNE1_ENST00000423061.1_Silent_p.H2730H|SYNE1_ENST00000448038.1_Silent_p.H2730H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2723					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACCTTTGAGCGTGGACGGAGG	0.458000										HNSCC(10;0.0054)			21	29					0	0	1	0	0
MPHOSPH10	10199	broad.mit.edu	37	2	71361867	71361867	+	Silent	SNP	T	T	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr2:71361867T>C	ENST00000244230.2	+	4	1390	c.1038T>C	c.(1036-1038)gtT>gtC	p.V346V	MPHOSPH10_ENST00000498451.2_Silent_p.V346V	NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	346					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						ATACAGGTGTTTTAAATGTAA	0.289000													6	89					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151093031	151093031	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chrX:151093031C>T	ENST00000370340.3	+	3	1162	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	MAGEA4_ENST00000393920.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000276344.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000360243.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000393921.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000370337.4_Missense_Mutation_p.R299C|MAGEA4_ENST00000370335.1_Missense_Mutation_p.R299C			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGCAAGAGTTCGCATTGCCTA	0.567000													8	85					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74995318	74995318	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr14:74995318C>T	ENST00000261978.4	-	12	2622	c.2236G>A	c.(2236-2238)Gag>Aag	p.E746K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E746K	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	746					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTTCCTCCTCCTCGGCTTTC	0.672000													20	15					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69250317	69250317	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr12:69250317G>A	ENST00000551568.1	-	9	1292	c.1232C>T	c.(1231-1233)cCa>cTa	p.P411L	CPM_ENST00000338356.3_Missense_Mutation_p.P411L|CPM_ENST00000546373.1_Missense_Mutation_p.P411L	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	411					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			AGGAATCATTGGGCATGAAGG	0.378000													30	38					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154573599	154573599	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr1:154573599C>T	ENST00000368474.4	-	2	1718	c.1519G>A	c.(1519-1521)Ggg>Agg	p.G507R	ADAR_ENST00000368471.3_Missense_Mutation_p.G212R|ADAR_ENST00000292205.5_Missense_Mutation_p.G550R	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	507	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding	p.G507W(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TCTAACAGCCCGCTGATGGGG	0.527000													11	54					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216289830	216289830	+	Silent	SNP	G	G	A	rs138120768	byFrequency	TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr2:216289830G>A	ENST00000354785.4	-	7	1392	c.1023C>T	c.(1021-1023)agC>agT	p.S341S	FN1_ENST00000443816.1_Silent_p.S341S|FN1_ENST00000432072.2_Silent_p.S341S|FN1_ENST00000421182.1_Silent_p.S341S|FN1_ENST00000426059.1_Silent_p.S341S|FN1_ENST00000357867.4_Silent_p.S341S|FN1_ENST00000357009.2_Silent_p.S341S|FN1_ENST00000356005.4_Silent_p.S341S|FN1_ENST00000346544.3_Silent_p.S341S|FN1_ENST00000345488.5_Silent_p.S341S|FN1_ENST00000336916.4_Silent_p.S341S|FN1_ENST00000323926.6_Silent_p.S341S|FN1_ENST00000359671.1_Silent_p.S341S|FN1_ENST00000446046.1_Silent_p.S341S			P02751	FINC_HUMAN	fibronectin 1	341	Collagen-binding.|Fibronectin type-I 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCTTGGCAGCTGACTCCGT	0.413000													9	178					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12337420	12337420	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr18:12337420C>T	ENST00000269143.3	-	16	2326	c.2095G>A	c.(2095-2097)Gat>Aat	p.D699N		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	699					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	CGTACTTCATCATCTATCAAT	0.428000													9	46					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653528	159653528	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr6:159653528G>A	ENST00000297267.9	+	11	2184	c.1984G>A	c.(1984-1986)Gcc>Acc	p.A662T	FNDC1_ENST00000340366.6_Missense_Mutation_p.A599T	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	662						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCCCAAGGGCGCCTTCGCCCA	0.672000													19	23					0	0	1	0	0
MS4A2	2206	broad.mit.edu	37	11	59860884	59860884	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr11:59860884C>G	ENST00000278888.3	+	5	492	c.390C>G	c.(388-390)agC>agG	p.S130R		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	130					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	TGAGAGGAAGCCTGGGAGCAA	0.488000													20	59					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11023079	11023079	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr5:11023079A>C	ENST00000304623.8	-	17	2990	c.2801T>G	c.(2800-2802)aTg>aGg	p.M934R	CTNND2_ENST00000458100.2_Missense_Mutation_p.M501R|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.M843R|CTNND2_ENST00000503622.1_Missense_Mutation_p.M597R|CTNND2_ENST00000359640.2_Missense_Mutation_p.M876R	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	934					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TAGGTCTCGCATGGCGTATTT	0.507000													18	35					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128235	147128235	+	Silent	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr3:147128235G>A	ENST00000282928.4	+	1	1065	c.336G>A	c.(334-336)gcG>gcA	p.A112A		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	112	Poly-Ala.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						ACGCGGCGGCGGCAGCCAGCG	0.701000													10	14					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73520433	73520433	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr7:73520433C>G	ENST00000418310.1	+	7	933	c.831C>G	c.(829-831)agC>agG	p.S277R	LIMK1_ENST00000336180.2_Missense_Mutation_p.S247R|LIMK1_ENST00000538333.3_Missense_Mutation_p.S213R			P53667	LIMK1_HUMAN	LIM domain kinase 1	247					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				AGGAAACCAGCCGCCTGCTCC	0.632000													41	62					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57099144	57099144	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr16:57099144A>G	ENST00000436936.1	+	33	4400	c.4175A>G	c.(4174-4176)gAc>gGc	p.D1392G	NLRC5_ENST00000539144.1_Missense_Mutation_p.D1363G|NLRC5_ENST00000262510.6_Missense_Mutation_p.D1392G|NLRC5_ENST00000308149.7_Missense_Mutation_p.D1363G			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1392					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				CCGTGGGCGGACAGAGCCAGG	0.602000													6	12					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155253944	155253944	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr4:155253944G>A	ENST00000357232.3	-	9	1918	c.1919C>T	c.(1918-1920)aCg>aTg	p.T640M	DCHS2_ENST00000339452.1_Missense_Mutation_p.T1139M	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	640	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATCCAGCCCGTGTAAGGGCG	0.517000													30	41					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778953	159778953	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr1:159778953C>A	ENST00000321935.6	+	5	629	c.543C>A	c.(541-543)gaC>gaA	p.D181E	FCRL6_ENST00000368106.3_Missense_Mutation_p.D174E|FCRL6_ENST00000339348.5_Missense_Mutation_p.D174E|FCRL6_ENST00000392235.3_Intron			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	174	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					AGGAGGGAGACTCTGGGCTTT	0.627000													22	28					1.10513e-12	1.2179e-12	1	1	0
ZNF831	128611	broad.mit.edu	37	20	57767047	57767047	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr20:57767047A>G	ENST00000371030.2	+	1	973	c.973A>G	c.(973-975)Aag>Gag	p.K325E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	325						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGCAGCGGAGAAGCCCTGGGA	0.711000													13	24					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160174524	160174524	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr6:160174524G>C	ENST00000358372.4	+	7	2242	c.485G>C	c.(484-486)cGa>cCa	p.R162P	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	162					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GCGAAGTGTCGAATGCTTATC	0.428000													17	26					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12600768	12600768	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr8:12600768T>G	ENST00000398246.3	-	2	814	c.745A>C	c.(745-747)Att>Ctt	p.I249L	LONRF1_ENST00000533751.1_5'UTR|LONRF1_ENST00000530693.1_5'UTR	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	249					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		GCTCTGTAAATTTTTACAATC	0.303000													17	5					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669500	158669500	+	Missense_Mutation	SNP	C	C	T	rs141972386		TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr1:158669500C>T	ENST00000359610.2	-	1	986	c.943G>A	c.(943-945)Gta>Ata	p.V315I		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V315I(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					CCTGGTCTTACGGAAAAAAAT	0.368000													16	27					0	0	1	0	0
ATP9B	374868	broad.mit.edu	37	18	76873307	76873307	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr18:76873307G>C	ENST00000426216.2	+	4	528	c.511G>C	c.(511-513)Gta>Cta	p.V171L	ATP9B_ENST00000586722.1_Missense_Mutation_p.V171L|ATP9B_ENST00000307671.7_Missense_Mutation_p.V171L|ATP9B_ENST00000458297.2_Missense_Mutation_p.V119L|ATP9B_ENST00000591464.1_Intron	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	171					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CTCACAGTTTGTACCAGCATT	0.289000													3	54					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38138690	38138690	+	Silent	SNP	G	G	A			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr13:38138690G>A	ENST00000379747.4	-	22	2556	c.2439C>T	c.(2437-2439)ccC>ccT	p.P813P	POSTN_ENST00000541481.1_Silent_p.P726P|POSTN_ENST00000541179.1_Silent_p.P758P|POSTN_ENST00000379742.4_Silent_p.P756P|POSTN_ENST00000379749.4_Silent_p.P785P|POSTN_ENST00000379743.4_Silent_p.P786P	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	813					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ACTTCCTCACGGGTGTGTCTA	0.348000													4	85					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	38					0	0	1	0	0
ACP1	52	broad.mit.edu	37	2	271876	271876	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr2:271876T>G	ENST00000272067.6	+	2	150	c.54T>G	c.(52-54)tgT>tgG	p.C18W	ACP1_ENST00000272065.5_Missense_Mutation_p.C18W|ACP1_ENST00000439645.2_Missense_Mutation_p.C18W|ACP1_ENST00000484464.1_3'UTR|ACP1_ENST00000407983.3_Missense_Mutation_p.C18W|ACP1_ENST00000405233.1_Missense_Mutation_p.C18W	NM_007099.3	NP_009030.1	P24666	PPAC_HUMAN	acid phosphatase 1, soluble	18				CLGNICRS -> PARREAAR (in Ref. 5; AAB27085).		cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		GTAACATTTGTCGATCACCCA	0.453000													34	37					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108912	147108913	+	Frame_Shift_Ins	INS	-	-	C			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr3:147108912_147108913insC	ENST00000383075.3	-	4	1321_1322	c.809_810insG	c.(808-810)gtgfs	p.V270fs	ZIC4_ENST00000425731.3_Frame_Shift_Ins_p.V308fs|ZIC4_ENST00000484399.1_Frame_Shift_Ins_p.V270fs|ZIC4_ENST00000473123.1_Frame_Shift_Ins_p.V270fs|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000491672.1_Frame_Shift_Ins_p.V64fs|ZIC4_ENST00000525172.2_Frame_Shift_Ins_p.V320fs	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	270						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						ACTTGTCGCAGCCCCGCACCTT	0.639													21	26	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184046495	184046496	+	Frame_Shift_Ins	INS	-	-	T			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr3:184046495_184046496insT	ENST00000342981.4	+	26	4447_4448	c.4033_4034insT	c.(4033-4035)aacfs	p.N1345fs	EIF4G1_ENST00000352767.3_Frame_Shift_Ins_p.N1351fs|EIF4G1_ENST00000411531.1_Frame_Shift_Ins_p.N1305fs|EIF4G1_ENST00000382330.3_Frame_Shift_Ins_p.N1351fs|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000346169.2_Frame_Shift_Ins_p.N1344fs|EIF4G1_ENST00000414031.1_Frame_Shift_Ins_p.N1304fs|EIF4G1_ENST00000441154.1_Frame_Shift_Ins_p.N1181fs|EIF4G1_ENST00000319274.6_Frame_Shift_Ins_p.N1344fs|EIF4G1_ENST00000392537.2_Frame_Shift_Ins_p.N1257fs|EIF4G1_ENST00000427845.1_Frame_Shift_Ins_p.N1258fs|EIF4G1_ENST00000350481.5_Frame_Shift_Ins_p.N1180fs|EIF4G1_ENST00000434061.2_Frame_Shift_Ins_p.N1149fs|EIF4G1_ENST00000424196.1_Frame_Shift_Ins_p.N1351fs|EIF4G1_ENST00000435046.2_Frame_Shift_Ins_p.N1148fs	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1344	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCGGAACTGGTAACACCCATT	0.530													45	69	---	---	---	---					
KAT6B	23522	broad.mit.edu	37	10	76784946	76784949	+	Frame_Shift_Del	DEL	ACAA	ACAA	-			TCGA-KK-A8IA-01A-11D-A364-08	TCGA-KK-A8IA-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4302b78b-6ed4-42e0-b730-520da1966483	48663fd9-664b-4ba1-a992-df8b0bc460e8	g.chr10:76784946_76784949delACAA	ENST00000287239.4	+	17	4092_4095	c.3603_3606delACAA	c.(3601-3606)agfs	p.RQ1201fs	KAT6B_ENST00000372714.1_Frame_Shift_Del_p.RQ909fs|KAT6B_ENST00000372724.1_Frame_Shift_Del_p.RQ909fs|KAT6B_ENST00000372725.1_Frame_Shift_Del_p.RQ909fs|KAT6B_ENST00000372711.1_Frame_Shift_Del_p.RQ1018fs|KAT6B_ENST00000490365.1_3'UTR	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1201					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GGAAGAAAAGACAAACAGAGGAAG	0.451													14	23	---	---	---	---