Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MDGA2	161357	broad.mit.edu	37	14	47600938	47600938	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr14:47600938A>C	ENST00000426342.1	-	5	756	c.10T>G	c.(10-12)Ttt>Gtt	p.F4V	MDGA2_ENST00000439988.2_Missense_Mutation_p.F233V|MDGA2_ENST00000399232.2_Missense_Mutation_p.F302V|MDGA2_ENST00000357362.3_Missense_Mutation_p.F4V	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	233					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GACAGTCTAAACGACACCATC	0.318000													32	99					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													5	86					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129907280	129907280	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr10:129907280C>A	ENST00000368654.3	-	13	3199	c.2824G>T	c.(2824-2826)Gat>Tat	p.D942Y	MKI67_ENST00000368653.3_Missense_Mutation_p.D582Y	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	942					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATCTTTTCATCGTTTTCTTTT	0.388000													36	95					4.39465e-27	4.89215e-27	1	1	0
PTGS1	5742	broad.mit.edu	37	9	125154632	125154632	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr9:125154632C>T	ENST00000362012.2	+	11	1614	c.1609C>T	c.(1609-1611)Ccc>Tcc	p.P537S	PTGS1_ENST00000223423.4_Missense_Mutation_p.P500S|PTGS1_ENST00000373698.5_Missense_Mutation_p.P428S|PTGS1_ENST00000540753.1_Missense_Mutation_p.P475S	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	537					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CCTAGGGAATCCCATCTGTTC	0.522000													6	94					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152420001	152420001	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr6:152420001C>T	ENST00000440973.1	+	10	2058	c.1688C>T	c.(1687-1689)aCg>aTg	p.T563M	ESR1_ENST00000206249.3_Missense_Mutation_p.T563M|ESR1_ENST00000338799.5_Missense_Mutation_p.T563M|ESR1_ENST00000443427.1_Missense_Mutation_p.T563M|ESR1_ENST00000406599.1_Missense_Mutation_p.T302M|ESR1_ENST00000544394.1_Intron|ESR1_ENST00000456483.2_Missense_Mutation_p.T451M	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	563	Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding	p.T563M(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GTGGAGGAGACGGACCAAAGC	0.602000													5	37					0	0	1	0	0
SPR	6697	broad.mit.edu	37	2	73115592	73115592	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:73115592G>A	ENST00000234454.5	+	2	527	c.454G>A	c.(454-456)Gtg>Atg	p.V152M	SPR_ENST00000498749.1_3'UTR	NM_003124.4	NP_003115.1	P35270	SPRE_HUMAN	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)	152					nitric oxide biosynthetic process|tetrahydrobiopterin biosynthetic process	cytoplasm	aldo-keto reductase (NADP) activity|NADP binding|sepiapterin reductase activity			lung(4)|ovary(2)	6						CAACAGAACCGTGGTTAACAT	0.562000											OREG0014704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	75					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12898299	12898299	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr17:12898299C>T	ENST00000338034.4	-	20	2128	c.1889G>A	c.(1888-1890)cGa>cAa	p.R630Q	ELAC2_ENST00000395962.2_Missense_Mutation_p.R611Q|ELAC2_ENST00000426905.3_Missense_Mutation_p.R590Q	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	630					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						ATCACATGTTCGCAACAGCGA	0.527000													4	196					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085673	9085673	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:9085673T>C	ENST00000397910.4	-	1	6345	c.6142A>G	c.(6142-6144)Atc>Gtc	p.I2048V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2048	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGAAGTGATTGCATTCCTC	0.483000													4	115					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316880	40316880	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:40316880G>C	ENST00000593685.1	-	10	1926	c.1458C>G	c.(1456-1458)agC>agG	p.S486R	DYRK1B_ENST00000323039.5_Missense_Mutation_p.S486R|DYRK1B_ENST00000597639.1_Missense_Mutation_p.S458R|DYRK1B_ENST00000430012.2_Missense_Mutation_p.S446R|DYRK1B_ENST00000348817.3_Missense_Mutation_p.S458R			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	486	Interaction with RANBP9.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			AATATCGGTTGCTGTAGCGGT	0.612000													25	42					0	0	1	0	0
TAAR8	83551	broad.mit.edu	37	6	132874168	132874168	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr6:132874168G>T	ENST00000275200.1	+	1	337	c.337G>T	c.(337-339)Gca>Tca	p.A113S		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	113						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CTGTGATGTGGCATTTTGTTA	0.478000													6	193					3.59834e-05	3.72459e-05	1	1	0
UBQLNL	143630	broad.mit.edu	37	11	5537357	5537357	+	Silent	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:5537357G>A	ENST00000380184.1	-	1	578	c.315C>T	c.(313-315)ggC>ggT	p.G105G	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	105	Ubiquitin-like.									endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GAGATCTGGAGCCCTGCTTGG	0.542000													6	82					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152381049	152381049	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:152381049C>T	ENST00000427231.2	-	152	22556	c.22354G>A	c.(22354-22356)Gca>Aca	p.A7452T	NEB_ENST00000603639.1_Missense_Mutation_p.A7452T|NEB_ENST00000172853.10_Missense_Mutation_p.A5751T|NEB_ENST00000604864.1_Missense_Mutation_p.A7452T|NEB_ENST00000397345.3_Missense_Mutation_p.A7452T|NEB_ENST00000409198.1_Missense_Mutation_p.A5751T	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5751					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTTTGGCTGCCTGTGTGGCC	0.507000													4	129					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6711235	6711235	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr12:6711235T>C	ENST00000309577.6	-	4	492	c.329A>G	c.(328-330)tAt>tGt	p.Y110C	CHD4_ENST00000357008.2_Missense_Mutation_p.Y110C|CHD4_ENST00000544484.1_Missense_Mutation_p.Y107C|CHD4_ENST00000544040.1_Missense_Mutation_p.Y103C			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	110					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCAGGAGTATAGTCGCTGCC	0.552000													9	39					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123970988	123970988	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr10:123970988T>G	ENST00000369005.1	+	9	7388	c.7048T>G	c.(7048-7050)Ttt>Gtt	p.F2350V	TACC2_ENST00000260733.3_Missense_Mutation_p.F428V|TACC2_ENST00000334433.3_Missense_Mutation_p.F2350V|TACC2_ENST00000369000.1_Missense_Mutation_p.F54V|TACC2_ENST00000368999.1_Missense_Mutation_p.F428V|TACC2_ENST00000369004.3_Missense_Mutation_p.F428V|TACC2_ENST00000369001.1_Missense_Mutation_p.F54V|TACC2_ENST00000360561.3_Missense_Mutation_p.F428V|TACC2_ENST00000515603.1_Missense_Mutation_p.F2305V|TACC2_ENST00000515273.1_Missense_Mutation_p.F2354V|TACC2_ENST00000358010.1_Missense_Mutation_p.F496V|TACC2_ENST00000513429.1_Missense_Mutation_p.F496V|TACC2_ENST00000453444.2_Missense_Mutation_p.F2354V	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2350	SPAZ.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTTTAACCCTTTTTCTTCCAC	0.468000													22	152					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57608859	57608859	+	Silent	SNP	A	A	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr16:57608859A>T	ENST00000340339.4	+	11	1864	c.1341A>T	c.(1339-1341)gcA>gcT	p.A447A	GPR114_ENST00000394361.4_3'UTR|GPR114_ENST00000349457.3_Silent_p.A447A	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	447					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						GGGCGGATGCACCAAGTGTCA	0.652000													4	29					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89692911	89692911	+	Missense_Mutation	SNP	G	G	T	rs121909241		TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr10:89692911G>T	ENST00000371953.3	+	5	1752	c.395G>T	c.(394-396)gGt>gTt	p.G132V		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	132	Phosphatase tensin-type.		G -> V (in one patient with clinical findings suggesting hamartoma tumor syndrome).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.G132D(4)|p.Y27fs*1(2)|p.G132V(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*42(1)|p.F56fs*2(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGACGAACTGGTGTAATGATA	0.398000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			14	51					4.3838e-07	4.70262e-07	1	1	0
AOX1	316	broad.mit.edu	37	2	201515849	201515849	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:201515849T>G	ENST00000374700.2	+	26	3241	c.3000T>G	c.(2998-3000)aaT>aaG	p.N1000K	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	1000					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ATGCAGAGAATTATTGGAAGA	0.478000													10	110					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228860280	228860280	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:228860280C>T	ENST00000392056.3	-	8	4625	c.4579G>A	c.(4579-4581)Gaa>Aaa	p.E1527K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1527K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1527						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGGTTGTCTTCCTCATTGGCA	0.572000													4	133					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168501	25168501	+	RNA	SNP	G	G	A	rs4770716	by1000genomes	TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr13:25168501G>A	ENST00000453498.1	+	0	1173																											TTTTCTCTTCGGTGAGTAATC	0.388000													3	49					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95416419	95416419	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr8:95416419T>C	ENST00000336148.5	-	6	954	c.830A>G	c.(829-831)aAt>aGt	p.N277S		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ACAGTTCTTATTGAATACCCA	0.353000								Direct reversal of damage;Homologous recombination					28	58					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49760869	49760869	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr3:49760869T>G	ENST00000480687.1	-	3	282	c.166A>C	c.(166-168)Atg>Ctg	p.M56L	GMPPB_ENST00000308388.6_Missense_Mutation_p.M56L|GMPPB_ENST00000308375.6_Missense_Mutation_p.M56L|AMIGO3_ENST00000535833.1_5'UTR			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	56					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACCTGCGACATGTAGCTCACG	0.627000													10	64					0	0	1	0	0
MARCH6	10299	broad.mit.edu	37	5	10426565	10426565	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr5:10426565G>A	ENST00000274140.5	+	24	2569	c.2437G>A	c.(2437-2439)Gtg>Atg	p.V813M	MARCH6_ENST00000503788.1_Missense_Mutation_p.V708M|MARCH6_ENST00000510792.1_Missense_Mutation_p.V511M|MARCH6_ENST00000449913.2_Missense_Mutation_p.V765M	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	813					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						GGCAGCTCCCGTGATCTCTGT	0.428000													4	183					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75827179	75827179	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr6:75827179C>T	ENST00000322507.8	-	47	7747	c.7438G>A	c.(7438-7440)Gtg>Atg	p.V2480M	COL12A1_ENST00000345356.6_Missense_Mutation_p.V1316M|COL12A1_ENST00000483888.2_Missense_Mutation_p.V2480M|COL12A1_ENST00000416123.2_Missense_Mutation_p.V2480M	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2480	Nonhelical region (NC3).|VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACAATGAACACGTGCCGTTCA	0.418000													5	71					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141232707	141232707	+	Splice_Site	SNP	C	C	T	rs77794732		TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:141232707C>T	ENST00000389484.3	-	60	10596	c.9625_splice	c.e60+1	p.V3209_splice		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3209					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.V3209F(2)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGACCAACCTTTGTGTCTA	0.289000										TSP Lung(27;0.18)			13	89					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244876	46244876	+	Silent	SNP	G	G	A	rs78234941	by1000genomes	TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr12:46244876G>A	ENST00000334344.6	+	15	3142	c.2970G>A	c.(2968-2970)tcG>tcA	p.S990S	ARID2_ENST00000422737.1_Silent_p.S841S|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Silent_p.S600S	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	990	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCATGTCGTCGTCCTCTACCC	0.498000			"""N, S, F"""		hepatocellular carcinoma								9	86					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3304558	3304558	+	Silent	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr16:3304558G>A	ENST00000219596.1	-	2	549	c.510C>T	c.(508-510)gaC>gaT	p.D170D	MEFV_ENST00000541159.1_Intron|MEFV_ENST00000536379.1_Intron|MEFV_ENST00000339854.4_Intron	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	170					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	TGCCCTGCGCGTCCAGGCCCT	0.766000													3	6					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597054	36597054	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:36597054G>C	ENST00000299440.5	+	2	2312	c.2200G>C	c.(2200-2202)Gat>Cat	p.D734H		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	734					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				TACTCTTTGTGATGCCACCCG	0.498000									Familial Hemophagocytic Lymphohistiocytosis				10	80					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79254489	79254489	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr4:79254489C>T	ENST00000264895.6	+	19	2641	c.2201C>T	c.(2200-2202)cCt>cTt	p.P734L	FRAS1_ENST00000325942.6_Missense_Mutation_p.P734L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	734					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GACTGTGGGCCTTCCCATGTG	0.522000													10	13					0	0	1	0	0
CTC-260F20.3	0	broad.mit.edu	37	19	19627082	19627082	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:19627082C>T	ENST00000555938.1	+	1	47	c.35C>T	c.(34-36)cCg>cTg	p.P12L	CTC-260F20.3_ENST00000586674.1_3'UTR|NDUFA13_ENST00000507754.3_Missense_Mutation_p.P12L|NDUFA13_ENST00000252576.5_Missense_Mutation_p.P95L|NDUFA13_ENST00000503283.1_Missense_Mutation_p.P12L|NDUFA13_ENST00000428459.2_Missense_Mutation_p.P12L																							GACATGCCTCCGCCGGGGGGC	0.617000													16	36					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25464746	25464746	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr10:25464746A>C	ENST00000376351.3	+	1	756	c.397A>C	c.(397-399)Acc>Ccc	p.T133P	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	133						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GACACACGCCACCAACTTCCT	0.652000													5	78					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	52					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169826554	169826554	+	Splice_Site	SNP	C	C	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr2:169826554C>A	ENST00000263817.6	-	15	1934		c.e15+1			NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11						bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTCCACAAACCTTACTCAGC	0.512000													4	87					1	1	1	1	0
FGD3	89846	broad.mit.edu	37	9	95796871	95796871	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr9:95796871C>T	ENST00000375482.3	+	17	2330	c.1834C>T	c.(1834-1836)Cgg>Tgg	p.R612W	FGD3_ENST00000337352.6_Missense_Mutation_p.R612W|FGD3_ENST00000416701.2_Missense_Mutation_p.R611W|FGD3_ENST00000538555.1_Missense_Mutation_p.R215W	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	612	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						CGGCCCCCTGCGGCTGTCAGA	0.662000													3	58					0	0	1	0	0
METTL25	84190	broad.mit.edu	37	12	82796857	82796857	+	Silent	SNP	T	T	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr12:82796857T>C	ENST00000248306.3	+	5	1296	c.1227T>C	c.(1225-1227)agT>agC	p.S409S	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		GAGTTTGCAGTGTGGGTTGTT	0.393000													7	45					0	0	1	0	0
OR10H3	26532	broad.mit.edu	37	19	15852463	15852463	+	Silent	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:15852463C>T	ENST00000305892.1	+	1	261	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_013938.1	NP_039226.1	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H, member 3	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						CTGATCTGCTCTTCACCCATC	0.512000													11	294					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54667527	54667527	+	Silent	SNP	C	C	T	rs149954505		TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:54667527C>T	ENST00000376591.4	-	8	1355	c.1224G>A	c.(1222-1224)ccG>ccA	p.P408P	TMC4_ENST00000301187.4_Silent_p.P402P	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	408						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGAACACGGGCGGCAGCACAA	0.567000											OREG0003641	type=REGULATORY REGION|Gene=AK124406|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	29					0	0	1	0	0
PEX16	9409	broad.mit.edu	37	11	45937359	45937359	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:45937359C>T	ENST00000241041.3	-	4	271	c.254G>A	c.(253-255)tGg>tAg	p.W85*	PEX16_ENST00000378750.5_Nonsense_Mutation_p.W85*|PEX16_ENST00000532681.1_5'UTR|PEX16_ENST00000532554.1_Intron	NM_004813.2|NM_057174.2	NP_004804.1|NP_476515.1	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16	85					ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			large_intestine(2)|lung(2)|ovary(2)|skin(1)	7				GBM - Glioblastoma multiforme(35;0.223)		CACGCTCAGCCATGTCAGCAG	0.632000													10	128					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10470654	10470654	+	Silent	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr8:10470654G>A	ENST00000382483.3	-	4	1177	c.954C>T	c.(952-954)gaC>gaT	p.D318D		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	318					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		ACAGGCTGCCGTCCTCATTCA	0.662000													9	119					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846025	18846025	+	RNA	SNP	G	G	C	rs5993363		TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr22:18846025G>C	ENST00000412938.1	+	0	3383																											GACGTTGAAGGCTGCCTTCAG	0.647000													3	66					0	0	1	0	0
FLNA	0	broad.mit.edu	37	X	153588855	153588855	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chrX:153588855G>A	ENST00000422373.1	-	22	3556	c.3308C>T	c.(3307-3309)aCg>aTg	p.T1103M	FLNA_ENST00000360319.4_Missense_Mutation_p.T1103M|FLNA_ENST00000344736.4_Missense_Mutation_p.T1103M|FLNA_ENST00000369850.3_Missense_Mutation_p.T1103M	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1103					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCTCCACCGTCAGGCCCAG	0.687000											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	29	7					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86898058	86898058	+	Silent	SNP	A	A	G	rs141878978	byFrequency	TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr1:86898058A>G	ENST00000370565.4	+	5	753	c.591A>G	c.(589-591)tcA>tcG	p.S197S		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	197					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TTAGGTGTTCATCTGACATCA	0.333000													7	87					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113237027	113237027	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr8:113237027G>T	ENST00000297405.5	-	71	11341	c.11097C>A	c.(11095-11097)aaC>aaA	p.N3699K	CSMD3_ENST00000352409.3_Missense_Mutation_p.N3629K|CSMD3_ENST00000455883.2_Missense_Mutation_p.N3530K|CSMD3_ENST00000343508.3_Missense_Mutation_p.N3659K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3699						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCGTGTTCAAGTTGGGATCAA	0.433000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			54	122					5.82388e-19	6.36313e-19	1	1	0
OR4A5	81318	broad.mit.edu	37	11	51412102	51412102	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:51412102C>A	ENST00000319760.6	-	1	346	c.294G>T	c.(292-294)caG>caT	p.Q98H		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				CTATAAATAGCTGGCCCATGC	0.433000													21	38					2.27731e-05	2.3993e-05	1	1	0
SF3B2	10992	broad.mit.edu	37	11	65826471	65826471	+	Silent	SNP	C	C	T	rs61736588		TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:65826471C>T	ENST00000528302.1	+	9	1140	c.1086C>T	c.(1084-1086)taC>taT	p.Y362Y	SF3B2_ENST00000322535.6_Silent_p.Y379Y			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	379					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						CTGAAATTTACGAGCCCAACT	0.507000													3	75					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138591340	138591340	+	Translation_Start_Site	SNP	C	C	T			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr9:138591340C>T	ENST00000298466.5	-	0	34				SOHLH1_ENST00000425225.1_De_novo_Start_InFrame	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1						cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		AGCGACCCCACGCGCACGGCC	0.677000													5	4					0	0	1	0	0
TMEM136	219902	broad.mit.edu	37	11	120198157	120198157	+	Silent	SNP	T	T	C			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:120198157T>C	ENST00000375095.2	+	2	248	c.7T>C	c.(7-9)Tta>Cta	p.L3L	TMEM136_ENST00000529187.1_Silent_p.L25L|TMEM136_ENST00000531346.1_Intron|TMEM136_ENST00000314475.2_Silent_p.L25L	NM_001198671.1|NM_001198672.1|NM_001198673.1|NM_001198674.1|NM_001198675.1	NP_001185600.1|NP_001185601.1|NP_001185602.1|NP_001185603.1|NP_001185604.1	Q6ZRR5	TM136_HUMAN	transmembrane protein 136	3						integral to membrane				endometrium(1)|lung(2)|ovary(1)	4		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Hepatocellular(160;0.206)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.07e-06)		CAGGATGGCATTAGCTCTGTG	0.448000													8	68					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793293	65793293	+	Silent	SNP	G	G	A			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr11:65793293G>A	ENST00000312106.5	-	1	695	c.558C>T	c.(556-558)ccC>ccT	p.P186P		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	186	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						ACTCACTGTAGGGATTGGGTC	0.602000													5	55					0	0	1	0	0
HLA-V	0	broad.mit.edu	37	6	29760353	29760373	+	RNA	DEL	GCGGGCGCCGTGGATGGAGCA	GCGGGCGCCGTGGATGGAGCA	-	rs74661005	by1000genomes	TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr6:29760353_29760373delGCGGGCGCCGTGGATGGAGCA	ENST00000457107.1	+	0	223_243																											GGATGGAGCCGCGGGCGCCGTGGATGGAGCAGGAGGGGCCG	0.674													2	4	---	---	---	---					
TRBV7-7	0	broad.mit.edu	37	7	142120169	142120170	+	RNA	DEL	CA	CA	-			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr7:142120169_142120170delCA	ENST00000390377.1	-	0	49																											GTAGTCATCTcacacacacaca	0.426													9	30	---	---	---	---					
FAM66D	0	broad.mit.edu	37	8	11994626	11994627	+	RNA	DEL	GT	GT	-	rs138516564	by1000genomes	TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr8:11994626_11994627delGT	ENST00000434078.2	+	0	608					NR_027425.1																						gtatttgtgcgtgtgtgtgtgt	0.510													8	69	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr12:49087434_49087436delATG	ENST00000261900.3	-	9	1783_1785	c.1561_1563delCAT	c.(1561-1563)del	p.H521del		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGGTGATTATGATGATGATGA	0.443													7	304	---	---	---	---					
RP11-23E10.4	0	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													3	5	---	---	---	---					
ACPT	93650	broad.mit.edu	37	19	51293714	51293716	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KK-A8I6-01A-11D-A364-08	TCGA-KK-A8I6-11A-12D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b09465a0-6766-4401-8ab3-1f7b0ba892cd	05ab92d0-9cba-4cd0-9f18-31dd0ef37394	g.chr19:51293714_51293716delCTG	ENST00000270593.1	+	1	43_45	c.43_45delCTG	c.(43-45)del	p.L20del	ACPT_ENST00000270594.3_In_Frame_Del_p.L20del	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	20						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGGACCTCTCctgctgctgctgc	0.709													2	4	---	---	---	---