Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CA10	56934	broad.mit.edu	37	17	49710999	49710999	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:49710999G>A	ENST00000451037.2	-	8	1742	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	CA10_ENST00000340813.6_Missense_Mutation_p.R274C|CA10_ENST00000442502.2_Missense_Mutation_p.R268C|CA10_ENST00000570565.1_Missense_Mutation_p.R193C|CA10_ENST00000285273.4_Missense_Mutation_p.R268C	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	268					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTGAGCAGGCGCAAGGAATGC	0.512000													10	66					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26883148	26883148	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:26883148C>T	ENST00000374168.2	+	12	1074	c.920C>T	c.(919-921)tCc>tTc	p.S307F	RPS6KA1_ENST00000526792.1_Missense_Mutation_p.S215F|RPS6KA1_ENST00000530003.1_Missense_Mutation_p.S291F|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.S215F|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.S316F|RPS6KA1_ENST00000488985.1_3'UTR|RPS6KA1_ENST00000374166.4_Missense_Mutation_p.S296F	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	307	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		CTTTCAGGCTCCGGCCCTGAT	0.592000													20	52					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162338	90162338	+	RNA	SNP	T	T	C			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr16:90162338T>C	ENST00000567960.1	+	0	1074				TUBB8P7_ENST00000564451.1_RNA																							GACATCCCACTCCGGGGGCTA	0.483000													4	107					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179554578	179554578	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr2:179554578A>G	ENST00000589042.1	-	122	32032	c.31808T>C	c.(31807-31809)gTt>gCt	p.V10603A	TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V9359A|TTN_ENST00000591111.1_Missense_Mutation_p.V10286A|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10286	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAACAGGAACGGGAATCTT	0.378000													13	169					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	52					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822890	54822890	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:54822890T>G	ENST00000301219.3	-	5	625	c.506A>C	c.(505-507)gAc>gCc	p.D169A	LILRA5_ENST00000346508.3_Missense_Mutation_p.D157A|LILRA5_ENST00000432233.3_Missense_Mutation_p.D169A|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000446712.3_Missense_Mutation_p.D157A	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	169	Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AATGAACCTGTCGAATCTCAG	0.587000													34	58					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141767225	141767225	+	Splice_Site	SNP	C	C	T	rs7778384	by1000genomes	TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr7:141767225C>T	ENST00000475668.2	+	42	5058	c.5004_splice	c.e42+1	p.R1668_splice	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1668	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCCTGGAGCGCGTGAGTATGG	0.592000													3	23					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150923936	150923936	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr5:150923936C>G	ENST00000261800.5	-	9	6764	c.6752G>C	c.(6751-6753)gGg>gCg	p.G2251A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2251	Cadherin 19.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAAAATGACCCCAGAGCTGT	0.478000													13	41					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36018836	36018836	+	Silent	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:36018836G>A	ENST00000452271.2	-	1	376	c.348C>T	c.(346-348)ggC>ggT	p.G116G	SBSN_ENST00000518157.1_Silent_p.G116G	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	116	Ala/Gly/His-rich.					extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGACCCCATGGCCAAGCTTCT	0.572000													10	170					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													4	75					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920338	5920338	+	Silent	SNP	A	A	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr9:5920338A>T	ENST00000399933.3	-	8	5657	c.5658T>A	c.(5656-5658)ccT>ccA	p.P1886P	KIAA2026_ENST00000381461.2_Silent_p.P1856P	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1886										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TCTGAGTACCAGGTGCCAAAG	0.428000													4	185					0	0	1	0	0
ARHGEF1	0	broad.mit.edu	37	19	42409353	42409353	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:42409353C>T	ENST00000599846.1	+	25	2569	c.2444C>T	c.(2443-2445)gCc>gTc	p.A815V	ARHGEF1_ENST00000378152.4_Missense_Mutation_p.A741V|ARHGEF1_ENST00000354532.3_Missense_Mutation_p.A759V|ARHGEF1_ENST00000347545.4_Missense_Mutation_p.A726V|ARHGEF1_ENST00000337665.4_Missense_Mutation_p.A774V			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	759					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACTGAGACTGCCGGATCCCTG	0.662000													4	89					0	0	1	0	0
TRBV6-7	0	broad.mit.edu	37	7	142143906	142143906	+	RNA	SNP	G	G	C	rs146728507	by1000genomes	TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr7:142143906G>C	ENST00000390373.2	-	0	89																											TCTTCAGGACGTGGAATTTTG	0.527000													7	86					0	0	1	0	0
GPS1	2873	broad.mit.edu	37	17	80013939	80013939	+	Silent	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:80013939G>A	ENST00000392358.2	+	8	1366	c.1017G>A	c.(1015-1017)cgG>cgA	p.R339R	GPS1_ENST00000306823.6_Silent_p.R303R|GPS1_ENST00000355130.2_Silent_p.R339R|GPS1_ENST00000320548.4_Silent_p.R283R|GPS1_ENST00000578552.1_Silent_p.R299R	NM_212492.1	NP_997657.1	Q13098	CSN1_HUMAN	G protein pathway suppressor 1	303	PCI.				cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|skin(2)	13	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CCTTTGACCGGCAGGAGCTGC	0.652000													4	39					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76563157	76563157	+	Missense_Mutation	SNP	C	C	T	rs143602861	byFrequency	TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:76563157C>T	ENST00000389840.5	-	10	1500	c.1376G>A	c.(1375-1377)cGt>cAt	p.R459H	DNAH17_ENST00000585328.1_Missense_Mutation_p.R459H					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCATAGATACGGGTCACCAG	0.527000													3	28					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109794553	109794553	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:109794553C>T	ENST00000271332.3	+	1	1913	c.1852C>T	c.(1852-1854)Cgg>Tgg	p.R618W		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	618	Cadherin 5.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTACACAGTGCGGCTCAATGA	0.562000													4	113					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241689870	241689870	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr2:241689870G>A	ENST00000498729.2	-	28	3199	c.2953C>T	c.(2953-2955)Cgc>Tgc	p.R985C	KIF1A_ENST00000320389.7_Missense_Mutation_p.R884C	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	884					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACGGCCACGCGGAGGAAGCCC	0.657000													9	40					0	0	1	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26666643	26666643	+	Silent	SNP	C	C	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:26666643C>A	ENST00000226225.2	+	2	363	c.96C>A	c.(94-96)ctC>ctA	p.L32L	TNFAIP1_ENST00000583213.1_Intron|TNFAIP1_ENST00000544907.2_Intron	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	32	BTB.				apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		ATGTCCAGCTCAACGTGGGCG	0.637000													24	64					2.32416e-17	2.56132e-17	1	1	0
ZBTB4	57659	broad.mit.edu	37	17	7366351	7366351	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:7366351C>A	ENST00000311403.4	-	4	2289	c.1950G>T	c.(1948-1950)gaG>gaT	p.E650D	ZBTB4_ENST00000380599.4_Missense_Mutation_p.E650D	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	650	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		cctcctcatcctcctcctcct	0.607000													4	41					2.56e-06	2.71059e-06	1	1	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr2:209113113G>A	ENST00000415913.1	-	4	775	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	IDH1_ENST00000446179.1_Missense_Mutation_p.R132C|IDH1_ENST00000345146.2_Missense_Mutation_p.R132C			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								15	40					0	0	1	0	0
C19orf47	126526	broad.mit.edu	37	19	40828229	40828229	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:40828229C>A	ENST00000582783.1	-	9	841	c.829G>T	c.(829-831)Gct>Tct	p.A277S	C19orf47_ENST00000584868.1_5'UTR|C19orf47_ENST00000392035.2_Missense_Mutation_p.A210S	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	277										endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			CTGTCCCAAGCCAGATCCTCG	0.612000													16	35					1.37285e-15	1.48268e-15	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85450803	85450803	+	Silent	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr12:85450803C>T	ENST00000393217.2	+	8	2293	c.2232C>T	c.(2230-2232)gcC>gcT	p.A744A		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	744										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GGAGACTAGCCTGGATAAAAT	0.368000													101	225					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560758	44560758	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr18:44560758C>T	ENST00000332567.4	-	1	1230	c.878G>A	c.(877-879)cGt>cAt	p.R293H	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	293					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GGCAGGGACACGCTGGCCGCT	0.627000													51	92					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49723596	49723596	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr3:49723596G>A	ENST00000449682.2	-	9	1407	c.1046C>T	c.(1045-1047)cCc>cTc	p.P349L	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	335	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity	p.P335L(5)		NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGAGCCGTCGGGGTTCCGGCA	0.667000													3	42					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37038775	37038775	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr5:37038775A>G	ENST00000282516.8	+	34	6542	c.6043A>G	c.(6043-6045)Ata>Gta	p.I2015V	NIPBL_ENST00000448238.2_Missense_Mutation_p.I2015V	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2015					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATTCAGCAAAATAAGACCCCA	0.363000													11	25					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231333193	231333193	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:231333193A>G	ENST00000444294.3	+	2	1979	c.1121A>G	c.(1120-1122)aAc>aGc	p.N374S	TRIM67_ENST00000366652.2_Missense_Mutation_p.N374S|TRIM67_ENST00000449018.3_Missense_Mutation_p.N312S|TRIM67_ENST00000366653.5_Missense_Mutation_p.N374S	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	374						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CAGCTAAAGAACATATTGCAG	0.433000													3	67					0	0	1	0	0
USB1	79650	broad.mit.edu	37	16	58036476	58036476	+	Silent	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr16:58036476C>T	ENST00000219281.3	+	2	303	c.192C>T	c.(190-192)agC>agT	p.S64S	USB1_ENST00000423271.3_Silent_p.S64S|USB1_ENST00000539737.2_Silent_p.S64S|USB1_ENST00000565662.1_3'UTR|USB1_ENST00000561743.1_Silent_p.S13S|USB1_ENST00000563149.1_Silent_p.S64S	NM_024598.3	NP_078874.2			U6 snRNA biogenesis 1																		AAGATGACAGCACAAAACACG	0.592000													40	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091118	9091118	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:9091118G>T	ENST00000397910.4	-	1	900	c.697C>A	c.(697-699)Ctt>Att	p.L233I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	233	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAAGAATAAAGTGTCCCAAAT	0.463000													5	68					3.59834e-05	3.73673e-05	1	1	0
TRBV6-7	0	broad.mit.edu	37	7	142143907	142143907	+	RNA	SNP	T	T	C			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr7:142143907T>C	ENST00000390373.2	-	0	88																											CTTCAGGACGTGGAATTTTGG	0.527000													7	87					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151288289	151288289	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:151288289C>T	ENST00000368875.2	-	3	1285	c.705G>A	c.(703-705)atG>atA	p.M235I	PI4KB_ENST00000271657.5_Missense_Mutation_p.M235I|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000368873.1_Missense_Mutation_p.M223I|PI4KB_ENST00000368874.4_Missense_Mutation_p.M223I|PI4KB_ENST00000368872.1_Missense_Mutation_p.M223I	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	223					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGGAAATGTGCATGTCTGAAG	0.542000													23	34					0	0	1	0	0
SSTR5	0	broad.mit.edu	37	16	1129911	1129911	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr16:1129911C>T	ENST00000293897.4	+	1	1131	c.1043C>T	c.(1042-1044)cCa>cTa	p.P348L	SSTR5_ENST00000562758.1_Intron|SSTR5_ENST00000397547.2_Missense_Mutation_p.P348L	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	348				PPAHR -> RPRT (in Ref. 1; AAA20828).	negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GAGGCCACGCCACCCGCGCAC	0.701000													3	12					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299264	125299264	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chrX:125299264C>T	ENST00000538699.1	-	2	724	c.644G>A	c.(643-645)gGc>gAc	p.G215D	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.G215D	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	215										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						AGCCACGGTGCCGTCGCGGGA	0.642000													10	22					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137790074	137790074	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr7:137790074G>C	ENST00000242375.3	+	5	520	c.478G>C	c.(478-480)Gct>Cct	p.A160P	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000432161.1_Missense_Mutation_p.A160P|AKR1D1_ENST00000411726.2_Intron	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	160					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						TTGCAAAGACGCTGGCTTGGT	0.478000													61	113					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43943137	43943137	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr20:43943137C>A	ENST00000343694.3	+	9	1024	c.952C>A	c.(952-954)Cca>Aca	p.P318T	RBPJL_ENST00000464504.1_3'UTR|RBPJL_ENST00000372743.1_Missense_Mutation_p.P318T|RBPJL_ENST00000372741.3_Missense_Mutation_p.P318T	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	318					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				ATTCCAGTTTCCAGGCAGTCC	0.522000													4	123					0.00909568	0.00909568	1	1	0
MUC16	94025	broad.mit.edu	37	19	9057963	9057963	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr19:9057963G>A	ENST00000397910.4	-	3	29686	c.29483C>T	c.(29482-29484)tCc>tTc	p.S9828F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9830	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGGACAGAGGAATGAGATTC	0.463000													38	66					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16959803	16959803	+	RNA	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:16959803G>A	ENST00000412962.1	-	0	54																		p.A21A(1)									TTCCCAGGCCGGCCTCCTGGA	0.642000													5	19					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142505558	142505558	+	RNA	SNP	G	G	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr8:142505558G>T	ENST00000430863.1	-	0	368					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CACTGTTCATGTCCTGCAGCA	0.537000													21	43					4.54149e-19	5.10917e-19	1	1	0
ATG2A	23130	broad.mit.edu	37	11	64669827	64669827	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr11:64669827C>T	ENST00000421419.2	-	28	3929	c.3815G>A	c.(3814-3816)tGc>tAc	p.C1272Y	ATG2A_ENST00000377264.3_Missense_Mutation_p.C1270Y			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1270							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CACTGGGGGGCACGAGGGCAG	0.687000													9	10					0	0	1	0	0
WRNIP1	56897	broad.mit.edu	37	6	2770371	2770371	+	Silent	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr6:2770371C>T	ENST00000380769.4	+	3	603	c.372C>T	c.(370-372)caC>caT	p.H124H	WRNIP1_ENST00000380771.4_Intron|WRNIP1_ENST00000380773.4_Silent_p.H344H|WRNIP1_ENST00000380764.1_5'UTR			Q96S55	WRIP1_HUMAN	Werner helicase interacting protein 1	344					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				TCCTTCCTCACGTGGAATGTG	0.488000													24	51					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49723603	49723603	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr3:49723603G>A	ENST00000449682.2	-	9	1400	c.1039C>T	c.(1039-1041)Cgg>Tgg	p.R347W	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	333	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity	p.R333W(5)		NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCGGGGTTCCGGCAGAAGTTC	0.662000													3	42					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128901598	128901598	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chrX:128901598C>G	ENST00000371106.3	+	20	1952	c.1760C>G	c.(1759-1761)aCc>aGc	p.T587S		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	587					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						AGCTACCTGACCTTTGAAGTG	0.567000													54	17					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111217282	111217282	+	Silent	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr1:111217282C>T	ENST00000369769.2	-	1	373	c.150G>A	c.(148-150)ccG>ccA	p.P50P		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	50						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCATGTCGGGCGGCAGCTCGC	0.776000													5	17					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93999747	93999747	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr10:93999747C>G	ENST00000412050.4	-	2	449	c.361G>C	c.(361-363)Gac>Cac	p.D121H	CPEB3_ENST00000265997.4_Missense_Mutation_p.D121H	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	121	Pro-rich.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				AAGAAGCTGTCCTCTACCGCG	0.667000													5	7					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25044068	25044068	+	Silent	SNP	G	G	A	rs146166448	by1000genomes	TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr13:25044068G>A	ENST00000381989.3	-	16	2115	c.2010C>T	c.(2008-2010)ttC>ttT	p.F670F		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	670	VIT.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TGAAGGCTTCGAAGCCACACA	0.458000													3	19					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348634	197348634	+	RNA	SNP	G	G	C			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr3:197348634G>C	ENST00000418868.1	-	0	625					NR_003266.2																						CAGCAGCACCGATGGGCCTGC	0.542000													5	87					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99909507	99909507	+	Silent	SNP	C	C	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr7:99909507C>T	ENST00000332397.6	+	4	863	c.679C>T	c.(679-681)Ctg>Ttg	p.L227L	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	227										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						GGCAGAGACGCTGTGTGGCCT	0.587000													40	80					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947006	57947006	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr11:57947006G>T	ENST00000335397.3	+	3	406	c.90G>T	c.(88-90)ttG>ttT	p.L30F		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				TCTTCCTCTTGTTTTTATTTA	0.448000													4	144					0.000602214	0.000613577	1	1	0
PTEN	5728	broad.mit.edu	37	10	89717715	89717716	+	Frame_Shift_Ins	INS	-	-	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr10:89717715_89717716insA	ENST00000371953.3	+	7	2097_2098	c.740_741insA	c.(739-741)tccfs	p.S247fs	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	247	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.P248fs*5(13)|p.R55fs*1(5)|p.N212fs*1(2)|p.Y27fs*1(2)|p.L247*(2)|p.G165_*404del(1)|p.L247fs*6(1)|p.?(1)|p.L247fs*5(1)|p.L247fs*4(1)|p.L247F(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CCTCAGCCGTTACCTGTGTGTG	0.406		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			16	14	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283605	43283606	+	RNA	INS	-	-	A			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr11:43283605_43283606insA	ENST00000511537.1	-	0	1329_1330					NR_033868.1																						GAAGCAAATGTAAAAAAAAAAA	0.386													2	4	---	---	---	---					
ZNF268	10795	broad.mit.edu	37	12	133780636	133780636	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr12:133780636delT	ENST00000536435.2	+	6	2694	c.2364delT	c.(2362-2364)gcfs	p.A788fs	ZNF268_ENST00000542986.2_3'UTR|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000228289.5_Frame_Shift_Del_p.A788fs|ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000537565.1_Frame_Shift_Del_p.A627fs	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	788						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GTGGGAAAGCTTTTAGCAGCA	0.408													2	4	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													2	4	---	---	---	---					
HOXB4	3214	broad.mit.edu	37	17	46657168	46657169	+	Translation_Start_Site	DEL	AT	AT	-			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:46657168_46657169delAT	ENST00000332503.5	-	0	304_305				HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000472863.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						CTACATATACATATATATATAT	0.361													2	4	---	---	---	---					
TBCD	6904	broad.mit.edu	37	17	80900326	80900327	+	Splice_Site	INS	-	-	T			TCGA-KK-A6E7-01A-11D-A31L-08	TCGA-KK-A6E7-11A-11D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bde582d-6c64-4529-9771-e7f9df342b04	8a82ccc3-d5f6-4647-9699-604814692936	g.chr17:80900326_80900327insT	ENST00000355528.4	+	39	3696_3697	c.3564_splice	c.e39-1	p.R1189_splice	TBCD_ENST00000576691.1_3'UTR|TBCD_ENST00000539345.2_Splice_Site_p.R1227_splice	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	1189					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CTTCTTCAGCCTGGTGCCTGCT	0.619													31	46	---	---	---	---