Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IWS1	55677	broad.mit.edu	37	2	128262756	128262756	+	Silent	SNP	C	C	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr2:128262756C>T	ENST00000295321.4	-	3	982	c.723G>A	c.(721-723)gaG>gaA	p.E241E	AC010976.2_ENST00000599001.1_RNA|IWS1_ENST00000455721.2_Silent_p.E248E	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	241	3 X approximate tandem repeats.|Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GTTTGGGAAGCTCCTCATTTT	0.512000													34	112					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98608832	98608832	+	Missense_Mutation	SNP	T	T	G			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr7:98608832T>G	ENST00000359863.4	+	70	11263	c.11054T>G	c.(11053-11055)gTc>gGc	p.V3685G	TRRAP_ENST00000446306.3_Missense_Mutation_p.V3674G|TRRAP_ENST00000355540.3_Missense_Mutation_p.V3656G	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3685	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCGGAATTCGTCCTGCATTTA	0.532000													22	123					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9595085	9595085	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr18:9595085G>A	ENST00000400556.3	-	3	192	c.119C>T	c.(118-120)tCa>tTa	p.S40L	PPP4R1_ENST00000400555.3_Missense_Mutation_p.S23L	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	40					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						TTCATCTTGTGAGACAAAGTC	0.403000													18	34					0	0	1	0	0
TRAPPC6B	122553	broad.mit.edu	37	14	39623491	39623491	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr14:39623491T>C	ENST00000330149.5	-	4	501	c.275A>G	c.(274-276)tAt>tGt	p.Y92C	TRAPPC6B_ENST00000557764.1_5'UTR|TRAPPC6B_ENST00000347691.5_Intron	NM_001079537.1	NP_001073005.1	Q86SZ2	TPC6B_HUMAN	trafficking protein particle complex 6B	92					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0128)		CTGAAGTACATAGATGCCCTG	0.318000													4	10					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90296532	90296532	+	Nonsense_Mutation	SNP	A	A	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr9:90296532A>T	ENST00000469640.2	+	20	2590	c.2215A>T	c.(2215-2217)Aag>Tag	p.K739*	DAPK1_ENST00000408954.3_Nonsense_Mutation_p.K739*|DAPK1_ENST00000358077.5_Nonsense_Mutation_p.K739*|DAPK1_ENST00000472284.1_Nonsense_Mutation_p.K739*|DAPK1_ENST00000491893.1_Nonsense_Mutation_p.K739*			P53355	DAPK1_HUMAN	death-associated protein kinase 1	739					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CCTGGCTTCTAAGCCCACAGG	0.577000									Chronic Lymphocytic Leukemia, Familial Clustering of				4	13					0	0	1	0	0
GPR26	2849	broad.mit.edu	37	10	125426388	125426388	+	Silent	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr10:125426388G>A	ENST00000284674.1	+	1	518	c.465G>A	c.(463-465)tcG>tcA	p.S155S		NM_153442.3	NP_703143.1	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	155					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	20		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				TGTACGCCTCGTGCACGCTGT	0.692000													7	20					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56372898	56372898	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr19:56372898G>A	ENST00000301295.6	+	4	2425	c.2003G>A	c.(2002-2004)cGc>cAc	p.R668H	NLRP4_ENST00000587891.1_Missense_Mutation_p.R593H|NLRP4_ENST00000346986.5_Missense_Mutation_p.R668H	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	668							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCAGCTGTCGCCTTCAGAAG	0.557000													20	39					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164735586	164735586	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr3:164735586C>A	ENST00000264382.3	-	30	3658	c.3596G>T	c.(3595-3597)gGc>gTc	p.G1199V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1199	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGAGTTGGGCCCAAAAACAT	0.333000										HNSCC(35;0.089)			3	25					2.56e-06	2.752e-06	1	1	0
CADM3	57863	broad.mit.edu	37	1	159166233	159166233	+	Silent	SNP	C	C	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr1:159166233C>T	ENST00000368125.4	+	6	928	c.771C>T	c.(769-771)cgC>cgT	p.R257R	CADM3_ENST00000368124.4_Silent_p.R291R|CTA-134P22.2_ENST00000415675.2_RNA	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	257	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					GTGAGGGTCGCGGCAATCCAG	0.507000											OREG0013913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	21					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	33					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27777905	27777905	+	Silent	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr6:27777905C>A	ENST00000369163.2	+	1	64	c.54C>A	c.(52-54)cgC>cgA	p.R18R		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	18					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						AGGCTCCGCGCAAGCAGCTGG	0.632000													12	85					6.40141e-05	6.71367e-05	1	1	0
C10orf107	219621	broad.mit.edu	37	10	63525768	63525768	+	Silent	SNP	C	C	G			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr10:63525768C>G	ENST00000330194.2	+	7	929	c.624C>G	c.(622-624)gcC>gcG	p.A208A		NM_173554.2	NP_775825.1	Q8IVU9	CJ107_HUMAN	chromosome 10 open reading frame 107	208										breast(1)|kidney(1)|lung(4)|prostate(1)|skin(1)	8	Prostate(12;0.016)					TGAAAAAGGCCTAAGGACTTG	0.403000													13	18					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54823997	54823997	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr20:54823997C>A	ENST00000243911.2	+	1	210	c.98C>A	c.(97-99)gCc>gAc	p.A33D		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	70					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			AGCAGCAGCGCCTTCTGTGAG	0.562000													31	112					1.26612e-14	1.51231e-14	1	1	0
SRPX2	27286	broad.mit.edu	37	X	99925824	99925824	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chrX:99925824G>A	ENST00000373004.3	+	11	1666	c.1238G>A	c.(1237-1239)cGc>cAc	p.R413H		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	413					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						CGCCTCACTCGCTCCTACTTC	0.517000											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	14					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154315375	154315375	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr1:154315375C>T	ENST00000368489.3	+	15	1490	c.1490C>T	c.(1489-1491)aCg>aTg	p.T497M		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	483					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GACCCCCACACGCATGAGTTC	0.552000													10	33					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062399	76062399	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr11:76062399G>A	ENST00000260045.3	-	5	1900	c.1795C>T	c.(1795-1797)Ctc>Ttc	p.L599F		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	599					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						AGAGCTTTGAGGTGCTGTTCT	0.408000													25	42					0	0	1	0	0
TAGLN3	29114	broad.mit.edu	37	3	111719774	111719774	+	Silent	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr3:111719774G>A	ENST00000393917.2	+	3	888	c.336G>A	c.(334-336)caG>caA	p.Q112Q	TAGLN3_ENST00000273368.4_Silent_p.Q112Q|TAGLN3_ENST00000486460.1_Silent_p.Q28Q|TAGLN3_ENST00000478951.1_Silent_p.Q112Q|TAGLN3_ENST00000455401.2_Silent_p.Q112Q	NM_013259.2	NP_037391.2	Q9UI15	TAGL3_HUMAN	transgelin 3	112	CH.				central nervous system development|muscle organ development					endometrium(2)|lung(5)|urinary_tract(1)	8						ACATCTTTCAGACGGTGGATC	0.473000													12	81					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58443955	58443955	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr20:58443955G>T	ENST00000357552.3	-	37	3992	c.3767C>A	c.(3766-3768)tCc>tAc	p.S1256Y	SYCP2_ENST00000371001.2_Missense_Mutation_p.S1256Y			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1256					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACTAGACTTGGATAATGAAGA	0.313000													5	25					0.184627	0.184627	1	1	0
CEACAM16	388551	broad.mit.edu	37	19	45211203	45211203	+	Silent	SNP	C	C	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr19:45211203C>T	ENST00000587331.1	+	6	1226	c.1011C>T	c.(1009-1011)acC>acT	p.T337T	CTB-171A8.1_ENST00000590796.1_RNA|CEACAM16_ENST00000405314.2_Silent_p.T337T	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	337										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				TAACACTGACCGTGCAGGGCT	0.672000													4	8					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369503	20369503	+	RNA	SNP	C	C	G	rs8103002	by1000genomes	TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr19:20369503C>G	ENST00000593655.1	-	0	199																											TTATTGACTGCTGTAGTGGTA	0.458000													4	54					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713808	183713808	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr4:183713808C>A	ENST00000511685.1	+	26	6106	c.5983C>A	c.(5983-5985)Caa>Aaa	p.Q1995K	TENM3_ENST00000406950.2_Missense_Mutation_p.Q1995K					teneurin transmembrane protein 3																		TAGATACAGGCAAATTGGTCC	0.413000													32	149					9.65963e-10	1.12261e-09	1	1	0
TNN	63923	broad.mit.edu	37	1	175046867	175046867	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr1:175046867G>T	ENST00000239462.4	+	2	426	c.313G>T	c.(313-315)Gtc>Ttc	p.V105F		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	105					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGCAGGCAGTGTCCAGGACCT	0.602000													7	51					3.09899e-07	3.41683e-07	1	1	0
MUC16	94025	broad.mit.edu	37	19	9080484	9080484	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr19:9080484C>A	ENST00000397910.4	-	2	9750	c.9547G>T	c.(9547-9549)Gcc>Tcc	p.A3183S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3184	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGCTGGGGCAGGCCACGTG	0.478000													7	54					8.12818e-05	8.32171e-05	1	1	0
MAFF	23764	broad.mit.edu	37	22	38609879	38609879	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr22:38609879T>C	ENST00000338483.2	+	2	381	c.19T>C	c.(19-21)Tcc>Ccc	p.S7P	MAFF_ENST00000538999.1_Intron|MAFF_ENST00000538320.1_Missense_Mutation_p.S7P|MAFF_ENST00000426621.2_Missense_Mutation_p.S7P|MAFF_ENST00000407965.1_Missense_Mutation_p.S7P			Q9ULX9	MAFF_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	7					blood coagulation|parturition|transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|skin(1)	3	Melanoma(58;0.045)					GGATCCCCTATCCAGCAAAGC	0.527000													7	39					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100975410	100975410	+	Missense_Mutation	SNP	C	C	G			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr9:100975410C>G	ENST00000375066.5	-	7	1556	c.1465G>C	c.(1465-1467)Gag>Cag	p.E489Q	TBC1D2_ENST00000493589.2_Intron|TBC1D2_ENST00000342112.5_Missense_Mutation_p.E271Q|TBC1D2_ENST00000375064.1_Missense_Mutation_p.E489Q|TBC1D2_ENST00000375063.1_Missense_Mutation_p.E29Q	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	489						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGGGCCTTCTCCTTCTCAGCC	0.592000													8	17					0	0	1	0	0
BMX	660	broad.mit.edu	37	X	15574250	15574250	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chrX:15574250C>T	ENST00000357607.2	+	19	2196	c.2008C>T	c.(2008-2010)Cgg>Tgg	p.R670W	BMX_ENST00000348343.6_Missense_Mutation_p.R670W|BMX_ENST00000342014.6_Missense_Mutation_p.R670W			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	670	Protein kinase.		R -> W (in a lung large cell carcinoma sample; somatic mutation).		cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity	p.R670W(3)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					TGAACCACTTCGGGAAAAAGA	0.383000													33	29					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770517	37770517	+	Missense_Mutation	SNP	G	G	A	rs140802260	byFrequency	TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr22:37770517G>A	ENST00000402918.1	-	3	1843	c.1058C>T	c.(1057-1059)gCg>gTg	p.A353V	ELFN2_ENST00000349653.3_Missense_Mutation_p.A353V|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	353	Fibronectin type-III.					cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CTCAGTGTGCGCCCGCAGTTT	0.587000													26	76					0	0	1	0	0
CTU2	348180	broad.mit.edu	37	16	88780127	88780127	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr16:88780127G>A	ENST00000567949.1	+	9	1168	c.1159G>A	c.(1159-1161)Gct>Act	p.A387T	CTU2_ENST00000312060.5_Missense_Mutation_p.A316T|CTU2_ENST00000378384.3_Missense_Mutation_p.A229T|CTU2_ENST00000453996.2_Missense_Mutation_p.A316T			Q2VPK5	CTU2_HUMAN	cytosolic thiouridylase subunit 2 homolog (S. pombe)	316					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			NS(1)|breast(1)|endometrium(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11						GAAGGAGGTCGCTTTCTACAA	0.637000													39	77					0	0	1	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309669	1309669	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr1:1309669G>C	ENST00000338370.3	-	2	609	c.209C>G	c.(208-210)tCc>tGc	p.S70C	AURKAIP1_ENST00000378853.3_Missense_Mutation_p.S70C|AURKAIP1_ENST00000489799.1_5'UTR|AURKAIP1_ENST00000338338.5_Missense_Mutation_p.S70C|AURKAIP1_ENST00000321751.5_Missense_Mutation_p.S70C			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	70					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGGCTGACGGACATCTTCCT	0.672000													11	33					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118529706	118529706	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr11:118529706G>A	ENST00000529101.1	-	13	1498	c.1453C>T	c.(1453-1455)Cgt>Tgt	p.R485C	TREH_ENST00000264029.4_Missense_Mutation_p.R485C|TREH_ENST00000530256.1_Missense_Mutation_p.R362C|TREH_ENST00000525958.1_Missense_Mutation_p.R454C|TREH_ENST00000397925.1_Missense_Mutation_p.R454C			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	485					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		TGGGCCCGACGTAAAGGTGCC	0.562000											OREG0021385	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	89					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3977524	3977524	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr17:3977524C>A	ENST00000381638.2	-	24	3729	c.3605G>T	c.(3604-3606)tGg>tTg	p.W1202L		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1202							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						ATCCAGCCCCCAAGACACGGC	0.587000													22	142					4.35082e-09	4.92329e-09	1	1	0
TMEM140	55281	broad.mit.edu	37	7	134849232	134849232	+	Silent	SNP	G	G	A			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr7:134849232G>A	ENST00000275767.2	+	2	262	c.39G>A	c.(37-39)ctG>ctA	p.L13L	C7orf49_ENST00000459937.1_Intron	NM_018295.4	NP_060765.4	Q9NV12	TM140_HUMAN	transmembrane protein 140	13						integral to membrane				kidney(1)|large_intestine(2)|lung(2)	5						ACCAGCTGCTGTTCATGAGCA	0.592000													15	125					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149776147	149776149	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr5:149776147_149776149delAAG	ENST00000451292.1	+	25	4303_4305	c.4195_4197delAAG	c.(4195-4197)del	p.K1403del	TCOF1_ENST00000504761.2_In_Frame_Del_p.K1366del|TCOF1_ENST00000439160.2_In_Frame_Del_p.K1329del|TCOF1_ENST00000445265.2_In_Frame_Del_p.K1290del|TCOF1_ENST00000323668.7_In_Frame_Del_p.K1289del|TCOF1_ENST00000377797.3_In_Frame_Del_p.K1367del|TCOF1_ENST00000513346.1_In_Frame_Del_p.K1366del			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	1366					skeletal system development	nucleolus	protein binding|transporter activity	p.K1362delK(1)|p.K1285delK(1)		NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCAGGAGCAAGAAGAAGAAGA	0.601													2	4	---	---	---	---					
TYSND1	219743	broad.mit.edu	37	10	71905929	71905931	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-J9-A52E-01A-11D-A26M-08	TCGA-J9-A52E-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	840aa1ee-fa15-4fc3-b292-886ab0dbfc06	8486179b-1f5d-4f30-9d89-0672c1e73383	g.chr10:71905929_71905931delCAG	ENST00000287078.6	-	1	411_413	c.412_414delCTG	c.(412-414)del	p.L138del	TYSND1_ENST00000335494.5_In_Frame_Del_p.L138del	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	138					proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						CCGGGCAGCTCAGCAGCAGCAGC	0.739													3	5	---	---	---	---