Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values t_alt_count t_ref_count validation_alt_allele validation_method validation_status validation_tumor_sample pox qox pox_cutoff isArtifactMode oxoGCut ZNF232 7775 broad.mit.edu 37 17 5009595 5009595 + Missense_Mutation SNP T T C TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr17:5009595T>C ENST00000250076.3 - 5 1513 c.859A>G c.(859-861)Agg>Ggg p.R287G ZNF232_ENST00000416429.2_3'UTR|ZNF232_ENST00000575898.1_Missense_Mutation_p.R278G NM_014519.2 NP_055334.2 Q9UNY5 ZN232_HUMAN zinc finger protein 232 260 viral reproduction nucleus DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2) 11 ACCATCTGCCTGAAACTTTCC 0.453000 4 111 0 0 1 0 0 PANK1 53354 broad.mit.edu 37 10 91371708 91371708 + Silent SNP C C G TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr10:91371708C>G ENST00000307534.4 - 2 956 c.801G>C c.(799-801)gtG>gtC p.V267V PANK1_ENST00000371774.2_Silent_p.V69V|PANK1_ENST00000342512.3_Silent_p.V42V|PANK1_ENST00000322191.6_Silent_p.V42V NM_148977.2 NP_683878.1 Q8TE04 PANK1_HUMAN pantothenate kinase 1 267 coenzyme A biosynthetic process|pantothenate metabolic process cytosol|nucleus ATP binding|pantothenate kinase activity cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2) 11 Bezafibrate(DB01393) TCAGGTTCTCCACTTCCTCTT 0.473000 11 79 0 0 1 0 0 KRTAP1-5 83895 broad.mit.edu 37 17 39183145 39183145 + Missense_Mutation SNP A A G TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr17:39183145A>G ENST00000361883.5 - 1 309 c.263T>C c.(262-264)aTc>aCc p.I88T NM_031957.1 NP_114163.1 Q9BYS1 KRA15_HUMAN keratin associated protein 1-5 88 15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP]. keratin filament p.I88T(11) central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2) 17 Breast(137;0.00043) STAD - Stomach adenocarcinoma(17;0.000371) GCAGGAGCTGATCTGGCAGCA 0.632000 3 50 0 0 1 0 0 NME8 51314 broad.mit.edu 37 7 37903970 37903970 + Missense_Mutation SNP A A C TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr7:37903970A>C ENST00000199447.4 + 9 847 c.475A>C c.(475-477)Att>Ctt p.I159L EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.I159L NM_016616.4 NP_057700.3 Q8N427 TXND3_HUMAN NME/NM23 family member 8 159 NDK 1. cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process cytoplasm|microtubule cytoskeleton ATP binding|nucleoside diphosphate kinase activity CAGTATTGCTATTATCAAACC 0.279000 3 13 0 0 1 0 0 LRRC8C 84230 broad.mit.edu 37 1 90178510 90178510 + Silent SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr1:90178510C>T ENST00000370454.4 + 3 636 c.381C>T c.(379-381)ttC>ttT p.F127F RP11-302M6.4_ENST00000370453.5_Intron|LRRC8C_ENST00000479252.1_Intron NM_032270.4 NP_115646.2 Q8TDW0 LRC8C_HUMAN leucine rich repeat containing 8 family, member C 127 endoplasmic reticulum membrane|integral to membrane breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1) 28 all_lung(203;0.126) all cancers(265;0.00756)|Epithelial(280;0.0313) CCAAGTATTTCCCTTACCTTG 0.433000 14 150 0 0 1 0 0 GPC5 2262 broad.mit.edu 37 13 92345964 92345964 + Silent SNP G G A rs147274494 TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr13:92345964G>A ENST00000377067.3 + 3 1221 c.849G>A c.(847-849)gcG>gcA p.A283A NM_004466.4 NP_004457.1 P78333 GPC5_HUMAN glypican 5 283 anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix heparan sulfate proteoglycan binding NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1) 69 all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163) Lung NSC(4;0.00454) GCTGCCTGGCGCACATGGCGG 0.552000 13 84 0 0 1 0 0 HELZ2 85441 broad.mit.edu 37 20 62196338 62196338 + Silent SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr20:62196338C>T ENST00000467148.1 - 8 3906 c.3837G>A c.(3835-3837)ccG>ccA p.P1279P HELZ2_ENST00000427522.2_Silent_p.P710P NM_001037335.2 NP_001032412.2 helicase with zinc finger 2, transcriptional coactivator CGATGCCCAGCGGGTAGTAGA 0.687000 3 28 0 0 1 0 0 FRMD3 257019 broad.mit.edu 37 9 85863147 85863147 + Missense_Mutation SNP A A C TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr9:85863147A>C ENST00000304195.3 - 14 1686 c.1480T>G c.(1480-1482)Ttg>Gtg p.L494V FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000328788.1_Missense_Mutation_p.L151V|FRMD3_ENST00000376438.1_Missense_Mutation_p.L494V|FRMD3_ENST00000376434.1_Missense_Mutation_p.L300V NM_001244960.1|NM_174938.5 NP_001231889.1|NP_777598.3 A2A2Y4 FRMD3_HUMAN FERM domain containing 3 494 cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane cytoskeletal protein binding breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1) 30 TCAGCAATCAAAAAGGCGTTT 0.478000 20 150 0 0 1 0 0 KLHDC4 54758 broad.mit.edu 37 16 87788845 87788845 + Silent SNP G G T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr16:87788845G>T ENST00000270583.5 - 4 382 c.324C>A c.(322-324)acC>acA p.T108T KLHDC4_ENST00000353170.5_Silent_p.T51T|KLHDC4_ENST00000347925.5_Silent_p.T108T NM_017566.3 NP_060036.2 Q8TBB5 KLDC4_HUMAN kelch domain containing 4 108 breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2) 21 BRCA - Breast invasive adenocarcinoma(80;0.0283) TGTCAACTTTGGTCCAGGTGT 0.502000 10 47 3.86212e-05 4.06018e-05 1 1 0 OR11A1 0 broad.mit.edu 37 6 29395335 29395335 + Silent SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr6:29395335C>T ENST00000377149.1 - 5 556 c.84G>A c.(82-84)ttG>ttA p.L28L OR11A1_ENST00000377148.1_Silent_p.L28L|OR11A1_ENST00000377147.2_Silent_p.L28L|OR5V1_ENST00000377154.1_Intron Q9GZK7 O11A1_HUMAN olfactory receptor, family 11, subfamily A, member 1 28 sensory perception of smell integral to membrane|plasma membrane olfactory receptor activity cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1) 19 CAATAAAAAACAAGAAATGCA 0.408000 4 83 0 0 1 0 0 MGA 23269 broad.mit.edu 37 15 42035035 42035035 + Missense_Mutation SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr15:42035035C>T ENST00000219905.7 + 15 5058 c.4877C>T c.(4876-4878)aCt>aTt p.T1626I MGA_ENST00000389936.4_Missense_Mutation_p.T1626I|MGA_ENST00000566586.1_Intron|MGA_ENST00000570161.1_Missense_Mutation_p.T1626I|MGA_ENST00000545763.1_Intron NM_001164273.1 NP_001157745.1 Q8IWI9 MGAP_HUMAN MGA, MAX dimerization protein 1626 Thr-rich. MLL1 complex DNA binding|sequence-specific DNA binding transcription factor activity NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2) 95 all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238) OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235) ACTAAAGAAACTACTTATTCT 0.448000 8 78 0 0 1 0 0 FRMD3 257019 broad.mit.edu 37 9 85863145 85863145 + Missense_Mutation SNP C C G TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr9:85863145C>G ENST00000304195.3 - 14 1688 c.1482G>C c.(1480-1482)ttG>ttC p.L494F FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000328788.1_Missense_Mutation_p.L151F|FRMD3_ENST00000376438.1_Missense_Mutation_p.L494F|FRMD3_ENST00000376434.1_Missense_Mutation_p.L300F NM_001244960.1|NM_174938.5 NP_001231889.1|NP_777598.3 A2A2Y4 FRMD3_HUMAN FERM domain containing 3 494 cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane cytoskeletal protein binding breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1) 30 CTTCAGCAATCAAAAAGGCGT 0.468000 20 148 0 0 1 0 0 OR6T1 219874 broad.mit.edu 37 11 123814182 123814182 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr11:123814182G>A ENST00000321252.2 - 1 398 c.364C>T c.(364-366)Cgt>Tgt p.R122C NM_001005187.1 NP_001005187.1 Q8NGN1 OR6T1_HUMAN olfactory receptor, family 6, subfamily T, member 1 122 sensory perception of smell integral to membrane|plasma membrane olfactory receptor activity p.R122S(1)|p.R122C(1) breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1) 40 Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22) BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401) GCCAGGTAACGATCCAGAGAC 0.527000 3 34 0 0 1 0 0 ZNF644 84146 broad.mit.edu 37 1 91406702 91406702 + Missense_Mutation SNP T T A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr1:91406702T>A ENST00000370440.1 - 3 426 c.209A>T c.(208-210)aAt>aTt p.N70I ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.N70I|ZNF644_ENST00000467231.1_Intron Q9H582 ZN644_HUMAN zinc finger protein 644 70 regulation of transcription, DNA-dependent|transcription, DNA-dependent nucleus DNA binding|zinc ion binding breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2) 47 all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101) all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173) AGTCAACGTATTATTTTTCTG 0.393000 14 94 0 0 1 0 0 MAP4K2 5871 broad.mit.edu 37 11 64559403 64559403 + Silent SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr11:64559403C>T ENST00000294066.2 - 27 2161 c.2070G>A c.(2068-2070)acG>acA p.T690T MAP4K2_ENST00000377350.3_Silent_p.T682T NM_004579.3 NP_004570.2 Q12851 M4K2_HUMAN mitogen-activated protein kinase kinase kinase kinase 2 690 CNH. activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting basolateral plasma membrane|Golgi membrane|soluble fraction ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2) 8 GGATGTCGGGCGTCAGGCCAG 0.692000 5 7 0 0 1 0 0 SLC6A13 6540 broad.mit.edu 37 12 369173 369173 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr12:369173G>A ENST00000343164.4 - 2 98 c.46C>T c.(46-48)Cca>Tca p.P16S SLC6A13_ENST00000436453.1_Missense_Mutation_p.P16S|SLC6A13_ENST00000445055.2_Missense_Mutation_p.P16S NM_016615.4 NP_057699.2 Q9NSD5 S6A13_HUMAN solute carrier family 6 (neurotransmitter transporter), member 13 16 neurotransmitter secretion integral to plasma membrane gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1) 28 all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142) OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239) GGATACACTGGTTTTGTCTCT 0.517000 20 179 0 0 1 0 0 NELFB 25920 broad.mit.edu 37 9 140157669 140157669 + Missense_Mutation SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr9:140157669C>T ENST00000343053.4 + 5 1115 c.778C>T c.(778-780)Cac>Tac p.H260Y NM_015456.3 NP_056271.2 negative elongation factor complex member B GGACCCGTGCCACAAGGTAGC 0.662000 11 67 0 0 1 0 0 L1CAM 3897 broad.mit.edu 37 X 153136389 153136389 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chrX:153136389G>A ENST00000370060.1 - 7 739 c.550C>T c.(550-552)Cgg>Tgg p.R184W L1CAM_ENST00000361699.4_Missense_Mutation_p.R184W|L1CAM_ENST00000370057.3_Missense_Mutation_p.R184W|L1CAM_ENST00000370055.1_Missense_Mutation_p.R179W|L1CAM_ENST00000361981.3_Missense_Mutation_p.R179W|L1CAM_ENST00000543994.1_Missense_Mutation_p.R186W|L1CAM_ENST00000538883.1_Missense_Mutation_p.R186W NM_001278116.1 NP_001265045.1 P32004 L1CAM_HUMAN L1 cell adhesion molecule 184 Ig-like C2-type 2. R -> Q (in HSAS; severe).|R -> W (in HSAS). axon guidance|blood coagulation|cell death|leukocyte migration integral to membrane NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1) 81 all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05) ATCGTCACCCGCTCGTCCTGC 0.612000 16 74 0 0 1 0 0 CDC42BPB 9578 broad.mit.edu 37 14 103416203 103416203 + Silent SNP G G T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr14:103416203G>T ENST00000361246.2 - 26 3636 c.3348C>A c.(3346-3348)cgC>cgA p.R1116R NM_006035.3 NP_006026.3 Q9Y5S2 MRCKB_HUMAN CDC42 binding protein kinase beta (DMPK-like) 1116 PH. actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction cell leading edge|cell-cell junction|cytoplasm|cytoskeleton ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1) 49 Melanoma(154;0.155) Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199) CTGCATATGCGCGCTGCCATC 0.557000 18 115 3.51602e-12 3.89613e-12 1 1 0 ANKRD17 26057 broad.mit.edu 37 4 73951097 73951097 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr4:73951097G>A ENST00000358602.4 - 30 7144 c.7028C>T c.(7027-7029)gCt>gTt p.A2343V ANKRD17_ENST00000509867.2_Missense_Mutation_p.A2230V|ANKRD17_ENST00000330838.6_Missense_Mutation_p.A2092V NM_032217.3 NP_115593.3 O75179 ANR17_HUMAN ankyrin repeat domain 17 2343 interspecies interaction between organisms cytoplasm|nucleus RNA binding NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3) 96 Breast(15;0.000295) Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154) AATGTTTGAAGCAAAGTTTCC 0.428000 4 161 0 0 1 0 0 ZAP70 7535 broad.mit.edu 37 2 98349377 98349377 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr2:98349377G>A ENST00000264972.5 + 5 810 c.595G>A c.(595-597)Gcc>Acc p.A199T ZAP70_ENST00000442208.1_Missense_Mutation_p.A73T|ZAP70_ENST00000463643.1_3'UTR NM_001079.3 NP_001070.2 P43403 ZAP70_HUMAN zeta-chain (TCR) associated protein kinase 70kDa 199 SH2 2. immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway cytosol|T cell receptor complex ATP binding|non-membrane spanning protein tyrosine kinase activity breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2) 29 GGGCACATACGCCCTGTCCCT 0.627000 5 59 0 0 1 0 0 NOS3 4846 broad.mit.edu 37 7 150699374 150699374 + Silent SNP T T C TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr7:150699374T>C ENST00000297494.3 + 14 2091 c.1734T>C c.(1732-1734)gaT>gaC p.D578D NOS3_ENST00000461406.1_Silent_p.D372D|NOS3_ENST00000467517.1_Silent_p.D578D|NOS3_ENST00000484524.1_Silent_p.D578D NM_000603.4 NP_000594.2 P29474 NOS3_HUMAN nitric oxide synthase 3 (endothelial cell) 578 Flavodoxin-like. anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia caveola|cytoskeleton|cytosol|Golgi membrane actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1) 50 all_neural(206;0.219) OV - Ovarian serous cystadenocarcinoma(82;0.0121) UCEC - Uterine corpus endometrioid carcinoma (81;0.168) L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360) GGAATGGGGATCCCCCGGAGA 0.562000 3 10 0 0 1 0 0 TATDN1 83940 broad.mit.edu 37 8 125535240 125535240 + Missense_Mutation SNP A A G TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr8:125535240A>G ENST00000276692.6 - 2 63 c.26T>C c.(25-27)aTt>aCt p.I9T TATDN1_ENST00000521546.1_5'UTR|TATDN1_ENST00000519548.1_Intron|TATDN1_ENST00000517678.1_5'UTR|TATDN1_ENST00000605953.1_Missense_Mutation_p.I9T NM_032026.3 NP_114415.1 Q6P1N9 TATD1_HUMAN TatD DNase domain containing 1 9 nucleus endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|upper_aerodigestive_tract(1) 15 Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108) STAD - Stomach adenocarcinoma(47;0.00288) GTTGATACCAATATCTGTAGA 0.328000 9 49 0 0 1 0 0 RNF213 57674 broad.mit.edu 37 17 78328255 78328255 + Missense_Mutation SNP G G A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr17:78328255G>A ENST00000582970.1 + 36 10884 c.10741G>A c.(10741-10743)Gta>Ata p.V3581I CTD-2047H16.4_ENST00000575034.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.V3630I|RNF213_ENST00000336301.6_Missense_Mutation_p.V1654I NM_001256071.1 NP_001243000.1 Q9HCF4 ALO17_HUMAN ring finger protein 213 0 NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3) 130 all_neural(118;0.0538) BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057) TTTCTTGCGGGTATCCAAGAT 0.552000 11 96 0 0 1 0 0 CAPN11 11131 broad.mit.edu 37 6 44144631 44144631 + Missense_Mutation SNP C C A TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr6:44144631C>A ENST00000398776.1 + 11 1171 c.1133C>A c.(1132-1134)aCg>aAg p.T378K CAPN11_ENST00000542245.1_Missense_Mutation_p.T378K NM_007058.3 NP_008989.2 Q9UMQ6 CAN11_HUMAN calpain 11 378 Calpain catalytic. proteolysis acrosomal vesicle calcium ion binding|calcium-dependent cysteine-type endopeptidase activity breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1) 36 all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273) Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536) TGCAACCTCACGCCTGATACA 0.597000 6 263 0.00198382 0.00203341 1 1 0 AQP7 364 broad.mit.edu 37 9 33385614 33385614 + Missense_Mutation SNP A A T rs140995428 by1000genomes TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr9:33385614A>T ENST00000541274.1 - 5 830 c.381T>A c.(379-381)agT>agA p.S127R AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000377425.4_Intron O14520 AQP7_HUMAN aquaporin 7 0 excretion|generation of precursor metabolites and energy cell-cell junction|cytoplasm|integral to plasma membrane glycerol channel activity|water channel activity NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1) 17 LUSC - Lung squamous cell carcinoma(29;0.00788) GBM - Glioblastoma multiforme(74;0.191) CCACAGAAAAACTCAAAGGAA 0.632000 5 116 0 0 1 0 0 UBN1 29855 broad.mit.edu 37 16 4910802 4910802 + Missense_Mutation SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr16:4910802C>T ENST00000396658.4 + 6 1512 c.809C>T c.(808-810)gCg>gTg p.A270V UBN1_ENST00000262376.6_Missense_Mutation_p.A270V|UBN1_ENST00000585857.1_3'UTR|UBN1_ENST00000590769.1_Missense_Mutation_p.A270V|UBN1_ENST00000545171.1_Missense_Mutation_p.A270V NM_016936.3 NP_058632.2 Q9NPG3 UBN1_HUMAN ubinuclein 1 270 chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter PML body|tight junction DNA binding|sequence-specific DNA binding transcription factor activity NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1) 38 AAGCCTGTTGCGGTCCCATCA 0.498000 4 113 0 0 1 0 0 TMF1 7110 broad.mit.edu 37 3 69097585 69097585 + Missense_Mutation SNP C C T TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr3:69097585C>T ENST00000543976.1 - 2 517 c.271G>A c.(271-273)Gat>Aat p.D91N CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000596274.1_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|TMF1_ENST00000398559.2_Missense_Mutation_p.D91N|CTD-2013N24.2_ENST00000598783.1_RNA NM_007114.2 NP_009045.2 P82094 TMF1_HUMAN TATA element modulatory factor 1 91 regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter Golgi membrane|nucleus DNA binding|protein binding|transcription cofactor activity cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1) 22 Lung NSC(201;0.0193)|Prostate(884;0.174) BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247) TCAGATTCATCGACCACAGTC 0.463000 31 229 0 0 1 0 0 DRD5 0 broad.mit.edu 37 4 9784063 9784063 + Missense_Mutation SNP A A G TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr4:9784063A>G ENST00000304374.2 + 1 806 c.410A>G c.(409-411)gAc>gGc p.D137G NM_000798.4 NP_000789.1 P21918 DRD5_HUMAN dopamine receptor D5 137 activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic integral to plasma membrane p.D137G(1) NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1) 57 Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624) ATCAGCGTGGACCGCTACTGG 0.612000 3 44 0 0 1 0 0 LNP1 348801 broad.mit.edu 37 3 100148586 100148588 + In_Frame_Del DEL GAT GAT - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr3:100148586_100148588delGAT ENST00000383693.3 + 2 1293_1295 c.13_15delGAT c.(13-15)del p.D10del LNP1_ENST00000489752.1_In_Frame_Del_p.D10del NM_001085451.1 NP_001078920.1 A1A4G5 LNP1_HUMAN leukemia NUP98 fusion partner 1 10 Poly-Asp. cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1) 6 GGAGCACAAAGATGATGATGATG 0.507 7 412 --- --- --- --- NAP1L5 266812 broad.mit.edu 37 4 89618431 89618433 + In_Frame_Del DEL CCT CCT - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr4:89618431_89618433delCCT ENST00000323061.5 - 1 953_955 c.473_475delAGG c.(472-477)gct>g p.EA158del HERC3_ENST00000543130.1_Intron|HERC3_ENST00000264345.3_Intron|HERC3_ENST00000402738.1_Intron NM_153757.2 NP_715638.1 Q96NT1 NP1L5_HUMAN nucleosome assembly protein 1-like 5 158 Glu-rich. nucleosome assembly nucleus protein binding endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1) 7 OV - Ovarian serous cystadenocarcinoma(123;0.000181) TCTGCCGCAGcctcctcctcctc 0.626 7 188 --- --- --- --- PEX1 5189 broad.mit.edu 37 7 92146721 92146721 + Frame_Shift_Del DEL T T - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr7:92146721delT ENST00000248633.4 - 5 1203 c.1108delA c.(1108-1110)ttfs p.I370fs PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000438045.1_Intron|PEX1_ENST00000428214.1_Frame_Shift_Del_p.I370fs NM_000466.2 NP_000457.1 O43933 PEX1_HUMAN peroxisomal biogenesis factor 1 370 microtubule-based peroxisome localization|protein import into peroxisome matrix cytosol|nucleus|peroxisomal membrane ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1) 41 all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592) Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123) GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23) TCTGACCTAATTTTTTTTTGA 0.353 8 120 --- --- --- --- DHX37 57647 broad.mit.edu 37 12 125465270 125465272 + In_Frame_Del DEL CTC CTC - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr12:125465270_125465272delCTC ENST00000308736.2 - 4 600_602 c.502_504delGAG c.(502-504)del p.E168del NM_032656.3 NP_116045.2 Q8IY37 DHX37_HUMAN DEAH (Asp-Glu-Ala-His) box polypeptide 37 168 ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding p.E168delE(3) breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3) 65 all_neural(191;0.101)|Medulloblastoma(191;0.163) OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653) CCGATTCCGActcctcctcctcc 0.690 3 6 --- --- --- --- CACNA1A 773 broad.mit.edu 37 19 13441098 13441098 + Frame_Shift_Del DEL G G - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr19:13441098delG ENST00000360228.5 - 10 1304 c.1305delC c.(1303-1305)ccfs p.P435fs CACNA1A_ENST00000573710.2_Frame_Shift_Del_p.P436fs NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2 NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2 O00555 CAC1A_HUMAN calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 436 cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion cytoplasm|nucleus syntaxin binding breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1) 42 OV - Ovarian serous cystadenocarcinoma(19;5.07e-21) Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230) CAGCCTCTTCGGGGTTGAGCA 0.488 2 4 --- --- --- --- CYP4F8 11283 broad.mit.edu 37 19 15733290 15733291 + RNA DEL GA GA - TCGA-J4-A67O-01A-11D-A30E-08 TCGA-J4-A67O-10A-01D-A30H-08 Untested Somatic Phase_I WXS none Illumina GAIIx 86a0580e-36fc-4afd-ae47-966d6b1dc108 f8e39928-9a59-4e5a-ba1e-f22910129528 g.chr19:15733290_15733291delGA ENST00000441682.2 + 0 708 P98187 CP4F8_HUMAN cytochrome P450, family 4, subfamily F, polypeptide 8 prostaglandin metabolic process|xenobiotic metabolic process endoplasmic reticulum membrane|integral to membrane|microsome alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1) 26 aggagagaaggagagagagaga 0.515 4 2 --- --- --- ---