Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NUP205	23165	broad.mit.edu	37	7	135300708	135300708	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr7:135300708A>G	ENST00000285968.6	+	24	3381	c.3355A>G	c.(3355-3357)Act>Gct	p.T1119A		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1119					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GCTTATGAAAACTGCCTCAAT	0.393000													17	45					0	0	1	0	0
ZNF253	56242	broad.mit.edu	37	19	20002792	20002792	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr19:20002792C>T	ENST00000589717.1	+	4	828	c.736C>T	c.(736-738)Cat>Tat	p.H246Y	ZNF253_ENST00000355650.4_Missense_Mutation_p.H170Y	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	246				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTTACTACACATAAGAAAAT	0.398000													9	83					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27481507	27481507	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:27481507A>G	ENST00000356183.4	-	31	4751	c.4736T>C	c.(4735-4737)cTc>cCc	p.L1579P	GTF3C1_ENST00000561623.1_Missense_Mutation_p.L1579P	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1579						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CACAGAAATGAGGCCCAGAGA	0.542000													5	219					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805634	115805634	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr9:115805634C>T	ENST00000374227.3	-	4	1291	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	ZFP37_ENST00000555206.1_Missense_Mutation_p.E423K|ZFP37_ENST00000553380.1_Missense_Mutation_p.E437K			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	422						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CTCACATGTTCGGTAAGAGAT	0.378000													18	79					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56379186	56379186	+	Silent	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr19:56379186C>T	ENST00000301295.6	+	6	2720	c.2298C>T	c.(2296-2298)ggC>ggT	p.G766G	NLRP4_ENST00000346986.5_Intron|NLRP4_ENST00000587891.1_Silent_p.G691G	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	766							ATP binding	p.G766G(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TAGACACAGGCGTGCCCCTTT	0.542000													5	102					0	0	1	0	0
METRN	79006	broad.mit.edu	37	16	767073	767073	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:767073A>G	ENST00000568223.2	+	4	743	c.568A>G	c.(568-570)Att>Gtt	p.I190V	METRN_ENST00000568415.1_Missense_Mutation_p.I57V	NM_024042.2	NP_076947.1	Q9UJH8	METRN_HUMAN	meteorin, glial cell differentiation regulator	190										skin(1)	1		Hepatocellular(780;0.00335)				CCCCACAGTAATTCACGGGAT	0.642000													19	31					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72403811	72403811	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr11:72403811C>T	ENST00000393609.3	-	30	4176	c.3974G>A	c.(3973-3975)gGg>gAg	p.G1325E	ARAP1_ENST00000393605.3_Missense_Mutation_p.G1085E|ARAP1_ENST00000359373.5_Intron|ARAP1_ENST00000334211.8_Missense_Mutation_p.G1080E|ARAP1-AS1_ENST00000542022.1_RNA|ARAP1_ENST00000495878.1_Intron|ARAP1_ENST00000455638.2_Intron|ARAP1_ENST00000429686.1_Intron|ARAP1_ENST00000426523.1_Intron	NM_001040118.2	NP_001035207.1	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1325	PH 4.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CTCAGGGGCCCCGCTCCACGG	0.612000													18	44					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24567694	24567694	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:24567694G>C	ENST00000319715.4	+	7	1032	c.600G>C	c.(598-600)atG>atC	p.M200I	RBBP6_ENST00000381039.3_Missense_Mutation_p.M200I|RBBP6_ENST00000348022.2_Missense_Mutation_p.M200I	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	200					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GTTTCATGATGGAAGTGAAAG	0.378000													14	66					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65174992	65174992	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr17:65174992G>A	ENST00000358691.5	-	13	1379	c.1213C>T	c.(1213-1215)Cgt>Tgt	p.R405C	HELZ_ENST00000580168.1_Missense_Mutation_p.R405C	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GAATCCCAACGTTTAGCTGTG	0.348000													13	92					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434627	79434627	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr14:79434627G>A	ENST00000554719.1	+	11	2452	c.1961G>A	c.(1960-1962)cGc>cAc	p.R654H	NRXN3_ENST00000335750.5_Missense_Mutation_p.R654H	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	260					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTGAATGGACGCCTGCCAGAC	0.522000													20	65					0	0	1	0	0
SDCBP	6386	broad.mit.edu	37	8	59490716	59490716	+	Missense_Mutation	SNP	A	A	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr8:59490716A>T	ENST00000523483.1	+	7	2101	c.587A>T	c.(586-588)aAg>aTg	p.K196M	SDCBP_ENST00000520168.1_Missense_Mutation_p.K117M|SDCBP_ENST00000424270.2_Missense_Mutation_p.K170M|SDCBP_ENST00000447182.2_Missense_Mutation_p.K175M|SDCBP_ENST00000447267.2_Missense_Mutation_p.K122M|SDCBP_ENST00000413219.2_Missense_Mutation_p.K176M|SDCBP_ENST00000260130.4_Missense_Mutation_p.K176M|SDCBP_ENST00000422546.2_Missense_Mutation_p.K175M			O00560	SDCB1_HUMAN	syndecan binding protein (syntenin)	176					actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	8		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AAAGCGCACAAGGTGCTCAAA	0.428000													19	64					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35210531	35210531	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr15:35210531T>C	ENST00000156471.5	-	15	1495	c.1270A>G	c.(1270-1272)Atg>Gtg	p.M424V		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	424						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TACAAAGGCATCTGGTTCAAC	0.368000													11	49					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59355	59355	+	Missense_Mutation	SNP	A	A	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:59355A>T	ENST00000509152.2	+	2	221	c.36A>T	c.(34-36)gaA>gaT	p.E12D	ZNF595_ENST00000339368.6_3'UTR|ZNF595_ENST00000526473.2_Missense_Mutation_p.E12D					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TGGCCATAGAATTCTCCCCTG	0.428000													13	516					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130286023	130286023	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr9:130286023A>G	ENST00000373312.3	-	5	737	c.524T>C	c.(523-525)aTg>aCg	p.M175T	FAM129B_ENST00000468379.1_Intron|FAM129B_ENST00000373314.3_Missense_Mutation_p.M162T	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	175	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGCTTCTGTCATCATGCAGAA	0.607000											OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	80					0	0	1	0	0
GRM8	0	broad.mit.edu	37	7	126173392	126173392	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr7:126173392T>C	ENST00000339582.2	-	9	2852	c.2044A>G	c.(2044-2046)Aaa>Gaa	p.K682E	GRM8_ENST00000444921.2_Missense_Mutation_p.K682E|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.K682E			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	682					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTGACAGATTTCTTCCCCTGC	0.507000										HNSCC(24;0.065)			7	91					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25565628	25565628	+	Silent	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr18:25565628G>A	ENST00000269141.3	-	12	2262	c.1839C>T	c.(1837-1839)tgC>tgT	p.C613C	CDH2_ENST00000399380.3_Silent_p.C582C	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	613	Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTGGAGTTTCGCAAGTCTCTG	0.408000													4	62					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577536	7577536	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr17:7577536T>C	ENST00000420246.2	-	7	877	c.745A>G	c.(745-747)Agg>Ggg	p.R249G	TP53_ENST00000359597.4_Missense_Mutation_p.R249G|TP53_ENST00000455263.2_Missense_Mutation_p.R249G|TP53_ENST00000413465.2_Missense_Mutation_p.R249G|TP53_ENST00000445888.2_Missense_Mutation_p.R249G|TP53_ENST00000269305.4_Missense_Mutation_p.R249G	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	249	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in a sporadic cancer; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in sporadic cancers; somatic mutation; dbSNP:rs28934571).|R -> T (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249W(37)|p.R249G(30)|p.0?(8)|p.?(5)|p.M246_P250delMNRRP(2)|p.R249R(1)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.N247_R248delNR(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.G245fs*14(1)|p.R249fs*15(1)|p.R249fs*14(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*19(1)|p.R249_I251delRPI(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGATGGGCCTCCGGTTCATG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	54					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176308519	176308519	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr5:176308519C>T	ENST00000292432.5	-	18	2502	c.2411G>A	c.(2410-2412)cGg>cAg	p.R804Q		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	804	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGGACCTGCCGCAGGGCCAG	0.637000													5	37					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123567	81123567	+	Silent	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:81123567G>A	ENST00000339711.4	+	10	2182	c.951G>A	c.(949-951)ccG>ccA	p.P317P	PRDM8_ENST00000415738.2_Silent_p.P317P|PRDM8_ENST00000504452.1_Silent_p.P317P	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	317	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						GGAAATTCCCGGAGGAGGCGG	0.741000													3	11					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28900188	28900188	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:28900188C>T	ENST00000395503.4	+	9	1193	c.1009C>T	c.(1009-1011)Ccc>Tcc	p.P337S	ATP2A1_ENST00000357084.3_Missense_Mutation_p.P337S|ATP2A1_ENST00000536376.1_Missense_Mutation_p.P212S	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	337					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						AAGAAGCTTGCCCTCCGTAGA	0.587000													5	302					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146823320	146823320	+	Nonsense_Mutation	SNP	G	G	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:146823320G>C	ENST00000508784.1	-	2	1318	c.1091C>G	c.(1090-1092)tCa>tGa	p.S364*	ZNF827_ENST00000513320.1_Intron|ZNF827_ENST00000379448.4_Nonsense_Mutation_p.S364*			Q17R98	ZN827_HUMAN	zinc finger protein 827	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGCCATACCTGAATTGGAGGG	0.448000													5	39					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93646352	93646352	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr1:93646352C>G	ENST00000557479.1	+	1	433	c.265C>G	c.(265-267)Cgg>Ggg	p.R89G	CCDC18_ENST00000334652.5_5'UTR|CCDC18_ENST00000401026.3_5'UTR|CCDC18_ENST00000338949.4_5'UTR|CCDC18_ENST00000343253.7_Intron	NM_206886.3	NP_996769.3	Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	0										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		CGCAGGGGCCCGGGAAAGGGT	0.672000													15	57					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167823646	167823646	+	Silent	SNP	A	A	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr1:167823646A>C	ENST00000367848.1	-	18	2474	c.1977T>G	c.(1975-1977)gtT>gtG	p.V659V	ADCY10_ENST00000545172.1_Silent_p.V598V|ADCY10_ENST00000367851.4_Silent_p.V751V			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	751					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTTGTTGGAAAACGAGTACCT	0.443000													22	96					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88688651	88688651	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:88688651C>T	ENST00000301011.5	+	9	1722	c.1522C>T	c.(1522-1524)Cag>Tag	p.Q508*	ZC3H18_ENST00000452588.2_Nonsense_Mutation_p.Q532*	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	508						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CACGGGGCCGCAGGTGAAGAG	0.602000													5	28					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145579796	145579796	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr8:145579796G>T	ENST00000331890.5	-	8	1368	c.1304C>A	c.(1303-1305)aCc>aAc	p.T435N	FBXL6_ENST00000526524.1_Intron|FBXL6_ENST00000455319.2_Missense_Mutation_p.T429N	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	435					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCACTTCTGGGTCAAAAAGGG	0.582000													4	134					0.00909568	0.00929341	1	1	0
WDR17	116966	broad.mit.edu	37	4	177071069	177071069	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:177071069T>C	ENST00000393643.2	+	14	2261	c.2009T>C	c.(2008-2010)cTg>cCg	p.L670P	WDR17_ENST00000507824.2_Missense_Mutation_p.L677P|WDR17_ENST00000508596.1_Missense_Mutation_p.L670P|WDR17_ENST00000280190.4_Missense_Mutation_p.L694P	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	694										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ATAAATATTCTGGCAGACAGA	0.393000													4	155					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62758468	62758468	+	Silent	SNP	G	G	A	rs145773574	by1000genomes	TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:62758468G>A	ENST00000512091.1	+	9	2118	c.1371G>A	c.(1369-1371)ccG>ccA	p.P457P	LPHN3_ENST00000514157.1_Silent_p.P457P|LPHN3_ENST00000509896.1_Silent_p.P525P|LPHN3_ENST00000508946.1_Silent_p.P457P|LPHN3_ENST00000545650.1_Silent_p.P457P|LPHN3_ENST00000508693.1_Silent_p.P525P|LPHN3_ENST00000507625.1_Silent_p.P525P|LPHN3_ENST00000514591.1_Silent_p.P457P|LPHN3_ENST00000507164.1_Silent_p.P525P|LPHN3_ENST00000506746.1_Silent_p.P525P|LPHN3_ENST00000511324.1_Silent_p.P525P|LPHN3_ENST00000506720.1_Silent_p.P525P|LPHN3_ENST00000504896.1_Silent_p.P457P|LPHN3_ENST00000514996.1_Silent_p.P457P|LPHN3_ENST00000506700.1_Silent_p.P457P			Q9HAR2	LPHN3_HUMAN	latrophilin 3	457					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GTACCACCCCGTCAGTGTCAG	0.522000													24	131					0	0	1	0	0
DPH7	92715	broad.mit.edu	37	9	140468754	140468754	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr9:140468754C>G	ENST00000277540.2	-	5	703	c.546G>C	c.(544-546)agG>agC	p.R182S	DPH7_ENST00000479650.1_5'UTR	NM_138778.2	NP_620133.1			diphthamide biosynthesis 7																		GCAGCCTGGGCCTCGTCTCAT	0.542000													37	150					0	0	1	0	0
EXOSC9	5393	broad.mit.edu	37	4	122723880	122723880	+	Silent	SNP	A	A	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:122723880A>C	ENST00000512454.1	+	2	381	c.165A>C	c.(163-165)gcA>gcC	p.A55A	EXOSC9_ENST00000243498.5_Silent_p.A71A|EXOSC9_ENST00000379663.3_Silent_p.A71A|EXOSC9_ENST00000509980.1_3'UTR			Q06265	EXOS9_HUMAN	exosome component 9	71	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|urinary_tract(1)	16						TCAATCGGGCAACAGAAGGTA	0.388000													19	78					0	0	1	0	0
CD200R1L	344807	broad.mit.edu	37	3	112538718	112538718	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr3:112538718G>A	ENST00000488794.1	-	7	1230	c.641C>T	c.(640-642)gCg>gTg	p.A214V	CD200R1L_ENST00000398214.1_Missense_Mutation_p.A235V|CD200R1L_ENST00000448932.1_Missense_Mutation_p.A214V			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	235	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						TAAGGACAACGCTGGAGATCC	0.373000													15	50					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209377	140209377	+	Silent	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr5:140209377G>A	ENST00000529310.1	+	1	1815	c.1701G>A	c.(1699-1701)gcG>gcA	p.A567A	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGCTGGCGCCTCGGGTGG	0.701000													38	186					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233351	43233351	+	Silent	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr19:43233351G>A	ENST00000327495.5	-	5	1351	c.1167C>T	c.(1165-1167)agC>agT	p.S389S	PSG3_ENST00000595140.1_Silent_p.S389S	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	389	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				CATAGAGCCCGCTATGCTTTG	0.468000													5	378					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325304	158325304	+	Silent	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr1:158325304C>T	ENST00000444681.2	+	2	566	c.273C>T	c.(271-273)tgC>tgT	p.C91C	CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368163.3_Silent_p.C190C|CD1E_ENST00000368167.3_Silent_p.C190C|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368161.3_Silent_p.C190C|CD1E_ENST00000368160.3_Silent_p.C190C|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000434258.1_Silent_p.C188C	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	190					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GTCACACCTGCCCTCGATTTC	0.507000													16	41					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48465260	48465260	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr3:48465260C>T	ENST00000358536.4	-	3	1030	c.761G>A	c.(760-762)cGg>cAg	p.R254Q	PLXNB1_ENST00000456774.1_Missense_Mutation_p.R254Q|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R254Q|PLXNB1_ENST00000358459.4_Missense_Mutation_p.R254Q	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	254	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGCTGGTCCCGGAGACACAC	0.622000													10	92					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88688650	88688650	+	Silent	SNP	G	G	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr16:88688650G>C	ENST00000301011.5	+	9	1721	c.1521G>C	c.(1519-1521)ccG>ccC	p.P507P	ZC3H18_ENST00000452588.2_Silent_p.P531P	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	507						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCACGGGGCCGCAGGTGAAGA	0.602000													5	28					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144844318	144844318	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr6:144844318G>A	ENST00000367545.3	+	40	5900	c.5900G>A	c.(5899-5901)cGg>cAg	p.R1967Q		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1967					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding	p.R1967L(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACAGTGATCGGAAAGGGTAT	0.378000													11	38					0	0	1	0	0
IGHV4-39	0	broad.mit.edu	37	14	106877737	106877737	+	RNA	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr14:106877737T>C	ENST00000390619.2	-	0	306																											CGGGTTGTAGTAGGTGCTCCC	0.567000													23	372					0	0	1	0	0
SPPL2A	84888	broad.mit.edu	37	15	51028899	51028899	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr15:51028899T>C	ENST00000261854.5	-	7	1046	c.772A>G	c.(772-774)Atg>Gtg	p.M258V		NM_032802.3	NP_116191.2	Q8TCT8	PSL2_HUMAN	signal peptide peptidase like 2A	258						integral to membrane	aspartic-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TACAGACTCATTGCTGATGCT	0.318000													4	49					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52919156	52919156	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr19:52919156A>G	ENST00000360465.3	+	7	1477	c.1051A>G	c.(1051-1053)Aaa>Gaa	p.K351E	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TACTGGTGAGAAACCTTACAA	0.388000													16	68					0	0	1	0	0
MRPS18C	51023	broad.mit.edu	37	4	84377254	84377254	+	Silent	SNP	C	C	T	rs141532727	byFrequency	TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr4:84377254C>T	ENST00000295491.4	+	1	137	c.24C>T	c.(22-24)tgC>tgT	p.C8C	MRPS18C_ENST00000507349.1_Silent_p.C8C|MRPS18C_ENST00000507019.1_Silent_p.C8C	NM_016067.2	NP_057151.1	Q9Y3D5	RT18C_HUMAN	mitochondrial ribosomal protein S18C	8					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5		Hepatocellular(203;0.114)				TTGCTGTTTGCGGTGGTCTAG	0.552000													5	315					0	0	1	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22354692	22354692	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr12:22354692C>A	ENST00000396037.4	-	5	1346	c.865G>T	c.(865-867)Gag>Tag	p.E289*	ST8SIA1_ENST00000539510.1_Nonsense_Mutation_p.E146*	NM_003034.3	NP_003025.1	Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	289					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						ATGGCCACCTCTTCACAGAGA	0.512000													19	80					1.67942e-08	1.75406e-08	1	1	0
SSPO	23145	broad.mit.edu	37	7	149509149	149509149	+	RNA	SNP	C	C	T			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr7:149509149C>T	ENST00000378016.2	+	0	9695							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACCCCCACACCTCTCTGCTCA	0.697000													20	56					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>AGGAGGggg	p.428_429insRR	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insRR	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													4	4	---	---	---	---					
GOLGA8DP	0	broad.mit.edu	37	15	22709885	22709885	+	RNA	DEL	G	G	-			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr15:22709885delG	ENST00000314246.8	-	0	1069																											TATCTAATGTGGGGGGGGCTG	0.537													6	12	---	---	---	---					
HERC2P9	0	broad.mit.edu	37	15	28900331	28900331	+	RNA	DEL	A	A	-			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr15:28900331delA	ENST00000528584.1	+	0	14					NR_036443.1																						actctgtctcaaaaaaaaaaa	0.413													4	5	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													5	1	---	---	---	---					
GMIP	51291	broad.mit.edu	37	19	19748340	19748340	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67L-01A-11D-A30E-08	TCGA-J4-A67L-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7657dad4-c2db-417a-a77c-4de308ef3f61	046e13f7-4c6e-4ee1-97c8-8adf4fa21c42	g.chr19:19748340delC	ENST00000203556.4	-	11	1095	c.958delG	c.(958-960)cgfs	p.A320fs	GMIP_ENST00000445806.2_Frame_Shift_Del_p.A320fs|GMIP_ENST00000587238.1_Frame_Shift_Del_p.A320fs	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	320					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCTGCCTGCGCCCCCCGCAGC	0.741													2	4	---	---	---	---