Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NACA	4666	broad.mit.edu	37	12	57111912	57111912	+	Silent	SNP	G	G	A	rs2926744		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr12:57111912G>A	ENST00000454682.1	-	3	3683	c.3402C>T	c.(3400-3402)ccC>ccT	p.P1134P	NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000552540.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTTGGGGAGGGAGGAGTTG	0.642000			T	BCL6	NHL								4	100					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38945049	38945049	+	Silent	SNP	T	T	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:38945049T>G	ENST00000357387.3	-	35	4785	c.4755A>C	c.(4753-4755)tcA>tcC	p.S1585S	RICTOR_ENST00000296782.5_Silent_p.S1609S	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1585					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TGCTGCTAGCTGAGCCTTCTT	0.408000													39	140					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5011016	5011016	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr10:5011016C>T	ENST00000380872.4	+	5	642	c.450C>T	c.(448-450)gcC>gcT	p.A150A	AKR1C1_ENST00000380859.1_Silent_p.A152A|AKR1C1_ENST00000477661.1_3'UTR|AKR1C1_ENST00000434459.2_Silent_p.A150A	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						TTTCCCAGGCCGTGGAGAAGT	0.463000													3	73					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	695199	695199	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr17:695199G>A	ENST00000304478.4	+	4	1259	c.1153G>A	c.(1153-1155)Ggt>Agt	p.G385S		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	385					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CGTTGTGCCTGGTGTGGACAG	0.637000													3	54					0	0	1	0	0
NKIRAS1	28512	broad.mit.edu	37	3	23934708	23934708	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr3:23934708C>T	ENST00000443659.2	-	4	1234	c.457G>A	c.(457-459)Gat>Aat	p.D153N	NKIRAS1_ENST00000412028.1_Missense_Mutation_p.D153N|NKIRAS1_ENST00000425478.2_Missense_Mutation_p.D153N|NKIRAS1_ENST00000437230.1_Missense_Mutation_p.D153N|NKIRAS1_ENST00000421515.2_Missense_Mutation_p.D153N|NKIRAS1_ENST00000415901.2_Missense_Mutation_p.D153N|NKIRAS1_ENST00000388759.3_Missense_Mutation_p.D153N|NKIRAS1_ENST00000416026.2_Missense_Mutation_p.D153N			Q9NYS0	KBRS1_HUMAN	NFKB inhibitor interacting Ras-like 1	153					I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	7						GTTTTCCGATCTGTAACAGTC	0.443000													9	55					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70506485	70506485	+	Silent	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr16:70506485A>G	ENST00000288078.6	+	14	1615	c.1383A>G	c.(1381-1383)gaA>gaG	p.E461E	FUK_ENST00000378912.2_Silent_p.E493E|FUK_ENST00000571514.1_5'UTR	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	461						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				CCTGGAGTGAATTCTTCAAGA	0.607000													9	38					0	0	1	0	0
CDK2	1017	broad.mit.edu	37	12	56365358	56365358	+	Silent	SNP	T	T	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr12:56365358T>C	ENST00000266970.4	+	7	1086	c.846T>C	c.(844-846)gcT>gcC	p.A282A	CDK2_ENST00000440311.2_Silent_p.A222A|CDK2_ENST00000556656.1_3'UTR|CDK2_ENST00000553376.1_Silent_p.A330A|CDK2_ENST00000354056.4_Silent_p.A248A	NM_001798.3	NP_001789.2	P24941	CDK2_HUMAN	cyclin-dependent kinase 2	282	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|blood coagulation|cell division|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA replication|G1/S transition of mitotic cell cycle|G2 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|histone phosphorylation|M/G1 transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation|Ras protein signal transduction|regulation of DNA replication|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol	ATP binding|cyclin-dependent protein kinase activity|identical protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	18			UCEC - Uterine corpus endometrioid carcinoma (6;0.123)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			CAGCCCTGGCTCACCCTTTCT	0.527000													38	124					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222301119	222301119	+	Splice_Site	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:222301119C>T	ENST00000281821.2	-	13	2387	c.2346_splice	c.e13+1	p.R782_splice	EPHA4_ENST00000409938.1_Splice_Site_p.R782_splice|EPHA4_ENST00000392071.4_Splice_Site_p.R731_splice|EPHA4_ENST00000409854.1_Splice_Site_p.R782_splice	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	782	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TCTTTCTTACCCTGGTGGTGT	0.448000													3	46					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16842993	16842993	+	Silent	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr17:16842993G>A	ENST00000437538.2	-	4	620	c.612C>T	c.(610-612)acC>acT	p.T204T	TNFRSF13B_ENST00000579315.1_Intron|TNFRSF13B_ENST00000261652.2_Silent_p.T250T|TNFRSF13B_ENST00000583789.1_Silent_p.T204T			O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	250					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						TGGGGTCGGGGGTCCCAGGCG	0.657000									IgA Deficiency, Selective				3	38					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68216515	68216515	+	Missense_Mutation	SNP	T	T	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr11:68216515T>C	ENST00000294304.7	+	23	4931	c.4825T>C	c.(4825-4827)Tcc>Ccc	p.S1609P	LRP5_ENST00000529481.1_3'UTR	NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1609	Pro-rich.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GCCCCCTCCGTCCCCCTGCAC	0.582000													3	119					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298898	125298898	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chrX:125298898C>T	ENST00000538699.1	-	2	1090	c.1010G>A	c.(1009-1011)cGc>cAc	p.R337H	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.R337H	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	337										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						GTTCTGCTGGCGCTGGCGCGG	0.622000													32	11					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189732	59189732	+	Missense_Mutation	SNP	G	G	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr11:59189732G>T	ENST00000302040.4	-	1	717	c.695C>A	c.(694-696)gCt>gAt	p.A232D		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						CCTACCTGTAGCTGAGCTGAT	0.483000													5	42					0.0215528	0.022859	1	1	0
OTUD6B	51633	broad.mit.edu	37	8	92090653	92090653	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr8:92090653G>A	ENST00000285420.4	+	4	574	c.475G>A	c.(475-477)Gga>Aga	p.G159R	OTUD6B_ENST00000404789.3_Missense_Mutation_p.G28R	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	129	OTU.									endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			AAACTTAACAGGAGCCAGACA	0.378000													2	8					0	0	1	0	0
MTRF1L	54516	broad.mit.edu	37	6	153319711	153319711	+	Missense_Mutation	SNP	T	T	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr6:153319711T>G	ENST00000367233.5	-	2	312	c.313A>C	c.(313-315)Aaa>Caa	p.K105Q	MTRF1L_ENST00000367230.1_Missense_Mutation_p.K105Q|MTRF1L_ENST00000367231.5_Missense_Mutation_p.K105Q|MTRF1L_ENST00000464135.1_5'UTR	NM_019041.5	NP_061914.3	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor 1-like	105						mitochondrion	translation release factor activity, codon specific			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	10		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		GTTATTTCTTTTTGACACAAA	0.303000													3	40					0	0	1	0	0
C2CD4B	388125	broad.mit.edu	37	15	62457107	62457107	+	Missense_Mutation	SNP	G	G	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr15:62457107G>C	ENST00000380392.3	-	2	205	c.77C>G	c.(76-78)aCg>aGg	p.T26R		NM_001007595.2	NP_001007596.2	A6NLJ0	C2C4B_HUMAN	C2 calcium-dependent domain containing 4B	26						nucleus				skin(1)	1						GCGATTCGGCGTGAGCACTTT	0.706000													2	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179402560	179402560	+	Missense_Mutation	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:179402560A>G	ENST00000589042.1	-	355	99598	c.99374T>C	c.(99373-99375)gTt>gCt	p.V33125A	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V30557A|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V24060A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V31484A|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V24185A|TTN_ENST00000342175.6_Missense_Mutation_p.V24252A|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000415561.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCCTTCCAACAATCTGGCA	0.433000													7	24					0	0	1	0	0
RUFY1	80230	broad.mit.edu	37	5	179023637	179023637	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:179023637G>A	ENST00000319449.4	+	13	1598	c.1586G>A	c.(1585-1587)aGg>aAg	p.R529K	RUFY1_ENST00000377001.2_3'UTR|RP11-1379J22.2_ENST00000500262.1_RNA|RUFY1_ENST00000437570.2_Missense_Mutation_p.R421K|RUFY1_ENST00000393438.2_Missense_Mutation_p.R421K	NM_025158.4	NP_079434.3	Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	529					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGCGGGAGGATCGGCGCC	0.687000										HNSCC(44;0.11)			3	111					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7802204	7802204	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr12:7802204G>A	ENST00000229304.4	-	5	670	c.650C>T	c.(649-651)aCg>aTg	p.T217M		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	217					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						TGGCGGAATCGTTTGGTAATG	0.398000													4	89					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12541141	12541141	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr19:12541141C>T	ENST00000301547.5	-	4	2042	c.1845G>A	c.(1843-1845)ccG>ccA	p.P615P	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	615					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						TACATTCATACGGGTTCTCTC	0.403000													3	59					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9364983	9364983	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr20:9364983C>T	ENST00000378501.2	+	11	1004	c.989C>T	c.(988-990)aCt>aTt	p.T330I	PLCB4_ENST00000378493.1_Missense_Mutation_p.T330I|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.T330I|PLCB4_ENST00000334005.3_Missense_Mutation_p.T330I|PLCB4_ENST00000278655.4_Missense_Mutation_p.T330I|PLCB4_ENST00000414679.2_Missense_Mutation_p.T330I	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	330	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TCCCATAACACTTATCTCACT	0.468000													19	75					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262078	39262078	+	Missense_Mutation	SNP	G	G	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr17:39262078G>T	ENST00000391415.1	+	1	495	c.438G>T	c.(436-438)caG>caT	p.Q146H		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	146	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						tgtgctgccagcccaactgct	0.667000													4	28					0.000602214	0.000669127	1	1	0
FN1	2335	broad.mit.edu	37	2	216259362	216259362	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:216259362G>A	ENST00000354785.4	-	24	4054	c.3685C>T	c.(3685-3687)Cag>Tag	p.Q1229*	FN1_ENST00000421182.1_Nonsense_Mutation_p.Q1229*|FN1_ENST00000346544.3_Nonsense_Mutation_p.Q1229*|FN1_ENST00000359671.1_Nonsense_Mutation_p.Q1229*|FN1_ENST00000357867.4_Nonsense_Mutation_p.Q1229*|FN1_ENST00000357009.2_Nonsense_Mutation_p.Q1229*|FN1_ENST00000356005.4_Nonsense_Mutation_p.Q1229*|FN1_ENST00000345488.5_Nonsense_Mutation_p.Q1229*|FN1_ENST00000336916.4_Nonsense_Mutation_p.Q1229*|FN1_ENST00000446046.1_Nonsense_Mutation_p.Q1229*|FN1_ENST00000443816.1_Nonsense_Mutation_p.Q1229*|FN1_ENST00000432072.2_Nonsense_Mutation_p.Q1229*|FN1_ENST00000323926.6_Nonsense_Mutation_p.Q1229*			P02751	FINC_HUMAN	fibronectin 1	1229	Fibronectin type-III 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGAGCTCTGATCAGCATGG	0.453000													6	144					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97194208	97194208	+	Missense_Mutation	SNP	C	C	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr3:97194208C>G	ENST00000389672.5	+	8	1945	c.1907C>G	c.(1906-1908)gCa>gGa	p.A636G	EPHA6_ENST00000514100.1_Missense_Mutation_p.A28G|EPHA6_ENST00000502694.1_Missense_Mutation_p.A28G|EPHA6_ENST00000442602.2_Missense_Mutation_p.A2G	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	541	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TCTGACATGGCAGCAGAACAA	0.403000													3	34					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77225016	77225016	+	Silent	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chrX:77225016G>A	ENST00000458128.1	-	1	119	c.120C>T	c.(118-120)cgC>cgT	p.R40R	ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000341514.6_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	40			R -> C.		glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						CCTGCCCGCCGCGCTTCGCCT	0.627000													7	79					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045693	26045693	+	Missense_Mutation	SNP	A	A	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr6:26045693A>C	ENST00000540144.1	+	1	55	c.55A>C	c.(55-57)Aag>Cag	p.K19Q		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	19					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						AGCTCCGCGCAAGCAGCTTGC	0.577000													7	60					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34247216	34247216	+	Missense_Mutation	SNP	T	T	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr17:34247216T>C	ENST00000394529.3	-	5	1145	c.659A>G	c.(658-660)gAa>gGa	p.E220G	RDM1_ENST00000293273.6_Missense_Mutation_p.E243G|RDM1_ENST00000425909.3_Intron|RDM1_ENST00000591402.1_Intron|RDM1_ENST00000431884.2_Missense_Mutation_p.E210G|RDM1_ENST00000419453.2_Missense_Mutation_p.E187G	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	243					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TAGTTCTTCTTCGCATCTGAC	0.373000								Other identified genes with known or suspected DNA repair function					7	89					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	80022520	80022520	+	Silent	SNP	C	C	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr9:80022520C>A	ENST00000360280.3	+	71	9731	c.9471C>A	c.(9469-9471)gcC>gcA	p.A3157A	VPS13A_ENST00000376636.3_Silent_p.A3118A|VPS13A_ENST00000484581.2_Silent_p.A93A|VPS13A_ENST00000376646.3_Silent_p.A93A	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	3157					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAGAGGATGCCAGGGtaaata	0.318000													3	31					0.014758	0.0158932	1	1	0
ADAMTS17	170691	broad.mit.edu	37	15	100533254	100533254	+	Splice_Site	SNP	G	G	A	rs142633005		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr15:100533254G>A	ENST00000268070.4	-	20	3053	c.2949_splice	c.e20+1	p.T983_splice		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	983	TSP type-1 5.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		TGCTCTCACCGTAGACCAGTC	0.617000													3	57					0	0	1	0	0
TSPAN15	23555	broad.mit.edu	37	10	71264232	71264232	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr10:71264232C>T	ENST00000373290.2	+	6	731	c.609C>T	c.(607-609)atC>atT	p.I203I	TSPAN15_ENST00000459981.1_3'UTR	NM_012339.3	NP_036471.1	O95858	TSN15_HUMAN	tetraspanin 15	203						integral to plasma membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	9						ACAAAACTATCGACAAGGAGG	0.423000													22	91					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													4	70					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34129958	34129958	+	Missense_Mutation	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr15:34129958A>G	ENST00000389232.4	+	89	11847	c.11777A>G	c.(11776-11778)gAc>gGc	p.D3926G	RYR3_ENST00000415757.3_Missense_Mutation_p.D3921G	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3926	EF-hand.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCAGCTCAGACACCTTCAAA	0.383000													3	16					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36488410	36488410	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr20:36488410C>T	ENST00000405275.2	+	15	1664	c.1421C>T	c.(1420-1422)gCc>gTc	p.A474V	CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.A249V|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.A501V|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.A314V			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	501					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TACATCATGGCCGAGATCTGC	0.587000													13	46					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193082053	193082053	+	Missense_Mutation	SNP	C	C	T	rs78621247		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr3:193082053C>T	ENST00000342358.4	-	2	197	c.80G>A	c.(79-81)cGg>cAg	p.R27Q		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	27					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding	p.R27L(1)|p.R27Q(1)		NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ATTGTGGTCCCGGTAACCAAA	0.443000													8	181					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186329110	186329110	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr4:186329110C>T	ENST00000264689.6	-	9	1217	c.1101G>A	c.(1099-1101)acG>acA	p.T367T		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	367						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GGATTTTTGACGTTATACCGA	0.373000													3	55					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155199080	155199080	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr3:155199080G>A	ENST00000460012.1	-	23	5002	c.4645C>T	c.(4645-4647)Cgc>Tgc	p.R1549C	PLCH1_ENST00000340059.7_Missense_Mutation_p.R1587C|PLCH1_ENST00000414191.1_Missense_Mutation_p.R1549C|PLCH1_ENST00000334686.6_Missense_Mutation_p.R1549C|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1587					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCAATATTGCGCACTCTGCTC	0.512000													9	123					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114214649	114214649	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr4:114214649C>T	ENST00000357077.4	+	22	2483	c.2430C>T	c.(2428-2430)gtC>gtT	p.V810V	ANK2_ENST00000509550.1_Silent_p.V19V|ANK2_ENST00000506722.1_Silent_p.V789V|ANK2_ENST00000264366.6_Silent_p.V810V|ANK2_ENST00000394537.3_Silent_p.V810V	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	810					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCTCCGTGGTCGACACCCTGA	0.488000													7	72					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118533574	118533574	+	Silent	SNP	C	C	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:118533574C>A	ENST00000311085.8	+	32	7748	c.7668C>A	c.(7666-7668)acC>acA	p.T2556T	DMXL1_ENST00000539542.1_Silent_p.T2556T	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2556										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAAGTCATACCGCCGAAGAGA	0.433000													3	140					1	1	1	1	0
TNP1	7141	broad.mit.edu	37	2	217724626	217724626	+	Silent	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:217724626G>A	ENST00000236979.2	-	1	161	c.132C>T	c.(130-132)ggC>ggT	p.G44G	AC007563.5_ENST00000447289.1_RNA	NM_003284.3	NP_003275.1	P09430	STP1_HUMAN	transition protein 1 (during histone to protamine replacement)	44					chromatin silencing|fertilization, exchange of chromosomal proteins|multicellular organismal development|nucleosome disassembly|single strand break repair|sperm motility|spermatid nucleus elongation	nucleosome	DNA binding			large_intestine(1)|lung(1)|stomach(1)	3		Renal(207;0.0822)		Epithelial(149;8.97e-07)|all cancers(144;2.46e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACCGTCATCGCCCCGTTTCC	0.547000													8	155					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75044488	75044488	+	Missense_Mutation	SNP	C	C	T	rs147333000	byFrequency	TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr15:75044488C>T	ENST00000343932.4	+	5	1129	c.1066C>T	c.(1066-1068)Cgg>Tgg	p.R356W		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	356					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CAGGGAGCGGCGGCCCCGGCT	0.592000													26	89					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204409361	204409361	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:204409361C>T	ENST00000367187.3	-	23	3894	c.3338G>A	c.(3337-3339)cGc>cAc	p.R1113H	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.R1085H	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	1113	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GATGACCATGCGCATGTCCAG	0.602000													4	161					0	0	1	0	0
SNX17	9784	broad.mit.edu	37	2	27599549	27599549	+	Missense_Mutation	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:27599549A>G	ENST00000233575.2	+	15	1598	c.1376A>G	c.(1375-1377)aAt>aGt	p.N459S	SNX17_ENST00000543024.1_Missense_Mutation_p.N245S|SNX17_ENST00000537606.1_Missense_Mutation_p.N434S|SNX17_ENST00000542478.1_Missense_Mutation_p.N245S	NM_001267059.1|NM_001267061.1|NM_014748.3	NP_001253988.1|NP_001253990.1|NP_055563.1	Q15036	SNX17_HUMAN	sorting nexin 17	459					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCACGGCAATTTCGCCTTC	0.547000													11	47					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6731108	6731108	+	Silent	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr19:6731108G>A	ENST00000264080.7	-	17	1475	c.1449C>T	c.(1447-1449)ggC>ggT	p.G483G	GPR108_ENST00000430424.4_Silent_p.G241G|GPR108_ENST00000598626.1_Intron	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	483						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						CCAGGGTGGAGCCCTCCACCA	0.692000													3	45					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463690	76463690	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr8:76463690C>T	ENST00000396423.2	+	4	544	c.420C>T	c.(418-420)tcC>tcT	p.S140S	HNF4G_ENST00000354370.1_Silent_p.S103S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	103					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACATCCCCTCCATTAACACAC	0.448000													7	64					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46760120	46760120	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr22:46760120C>T	ENST00000262738.3	-	34	8807	c.8808G>A	c.(8806-8808)ccG>ccA	p.P2936P		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2936					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCAGCGGCGGCGGGTAGGTGA	0.657000													7	91					0	0	1	0	0
POLR1C	9533	broad.mit.edu	37	6	43484884	43484884	+	Missense_Mutation	SNP	C	C	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr6:43484884C>G	ENST00000372389.3	+	1	125	c.37C>G	c.(37-39)Cgc>Ggc	p.R13G	POLR1C_ENST00000372344.2_Missense_Mutation_p.R13G|POLR1C_ENST00000304004.3_Missense_Mutation_p.R13G	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	13					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			AATGCGGAGCCGCGTGGTTCT	0.597000													7	121					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406691	148406691	+	Missense_Mutation	SNP	C	C	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:148406691C>A	ENST00000538184.1	-	7	2133	c.1245G>T	c.(1243-1245)gaG>gaT	p.E415D	SH3TC2_ENST00000394358.2_Missense_Mutation_p.E753D|SH3TC2_ENST00000515425.1_Missense_Mutation_p.E868D|SH3TC2_ENST00000512049.1_Missense_Mutation_p.E861D			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	868							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCTCCCACCTCCTGGGCTC	0.572000													5	184					1	1	1	1	0
MON2	23041	broad.mit.edu	37	12	62902191	62902191	+	Silent	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr12:62902191A>G	ENST00000393630.3	+	8	1306	c.915A>G	c.(913-915)ccA>ccG	p.P305P	MON2_ENST00000552115.1_Silent_p.P305P|MON2_ENST00000552738.1_Silent_p.P305P|MON2_ENST00000546600.1_Silent_p.P305P|MON2_ENST00000280379.6_Silent_p.P305P|MON2_ENST00000393629.2_Silent_p.P305P|MON2_ENST00000549378.1_3'UTR|MON2_ENST00000393632.2_Silent_p.P305P	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	305					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTGAAAAACCATATTTTCCTA	0.373000													37	80					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133914	119133914	+	Silent	SNP	A	A	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr3:119133914A>C	ENST00000264245.4	+	12	3670	c.3138A>C	c.(3136-3138)ctA>ctC	p.L1046L		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1046					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GAAAGGAGCTAGGGACACACC	0.592000													35	112					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976783	38976783	+	Missense_Mutation	SNP	G	G	A	rs147603571		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr19:38976783G>A	ENST00000355481.4	+	34	5619	c.5488G>A	c.(5488-5490)Gtc>Atc	p.V1830I	RYR1_ENST00000360985.3_Missense_Mutation_p.V1830I|RYR1_ENST00000359596.3_Missense_Mutation_p.V1830I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1830	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGCGACCCCGTCGGGGGCTC	0.667000													5	190					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110882266	110882266	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:110882266G>A	ENST00000369784.3	+	1	1139	c.239G>A	c.(238-240)aGc>aAc	p.S80N	RBM15_ENST00000487146.2_Missense_Mutation_p.S80N|RBM15_ENST00000602849.1_Missense_Mutation_p.S80N	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	80	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCTGGTGGCAGCAATGGGAGC	0.637000			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	54					0	0	1	0	0
TAF9	6880	broad.mit.edu	37	5	68660800	68660800	+	Silent	SNP	A	A	G			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:68660800A>G	ENST00000328663.4	-	3	1231	c.765T>C	c.(763-765)gaT>gaC	p.D255D	TAF9_ENST00000512561.1_Intron|TAF9_ENST00000506736.1_Silent_p.D255D|TAF9_ENST00000217893.5_Silent_p.D255D|TAF9_ENST00000502819.1_Intron|TAF9_ENST00000380818.3_Intron|TAF9_ENST00000380822.4_Intron	NM_001015892.1	NP_001015892.1	Q9Y3D8	KAD6_HUMAN	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	59						Cajal body	adenylate kinase activity|ATP binding|protein binding	p.D255D(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	8		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		catcatcatcatcgtcatcat	0.318000													3	57					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9323958	9323958	+	Missense_Mutation	SNP	G	G	A	rs113495544	byFrequency	TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:9323958G>A	ENST00000377403.2	+	5	1708	c.1406G>A	c.(1405-1407)cGg>cAg	p.R469Q	H6PD_ENST00000602477.1_Missense_Mutation_p.R480Q	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	469	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	TTCCATGGCCGGAAGAATTTC	0.597000													4	123					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105641939	105641939	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr7:105641939C>T	ENST00000542731.1	+	7	853	c.745C>T	c.(745-747)Ctg>Ttg	p.L249L	CDHR3_ENST00000470188.1_Intron|CDHR3_ENST00000541203.1_Silent_p.N149N|CDHR3_ENST00000317716.9_Silent_p.L249L|CDHR3_ENST00000343407.5_5'UTR|CDHR3_ENST00000478080.1_Silent_p.L161L			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	249	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CCTGGAGGAACTGAGTCCAGG	0.517000													5	97					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242142854	242142854	+	Missense_Mutation	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:242142854C>T	ENST00000274979.8	+	9	1095	c.992C>T	c.(991-993)cCc>cTc	p.P331L	ANO7_ENST00000402430.3_Missense_Mutation_p.P330L	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	331						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						AAGTACCAGCCCCTGGACCAC	0.687000													6	10					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082320	152082320	+	Missense_Mutation	SNP	T	T	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:152082320T>C	ENST00000368804.1	-	2	3372	c.3373A>G	c.(3373-3375)Aga>Gga	p.R1125G		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1125	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			cgttcctctctcagcagctgc	0.612000													4	109					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531778	92531778	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr11:92531778G>A	ENST00000298047.6	+	9	5616	c.5599G>A	c.(5599-5601)Gtt>Att	p.V1867I	FAT3_ENST00000409404.2_Missense_Mutation_p.V1867I|FAT3_ENST00000525166.1_Missense_Mutation_p.V1717I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1867	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAGAGTCCCGTTGAAGTCAA	0.453000										TCGA Ovarian(4;0.039)			6	30					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23559257	23559257	+	Missense_Mutation	SNP	G	G	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr14:23559257G>C	ENST00000262710.1	-	4	871	c.544C>G	c.(544-546)Ctg>Gtg	p.L182V	ACIN1_ENST00000605057.1_Missense_Mutation_p.L124V|ACIN1_ENST00000555053.1_Missense_Mutation_p.L182V|ACIN1_ENST00000457657.1_Intron	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	182	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGAGGCAGCAGGGAAGCCACT	0.582000													3	23					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124623669	124623669	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr11:124623669G>A	ENST00000278927.5	-	7	1175	c.1046C>T	c.(1045-1047)aCg>aTg	p.T349M	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	349					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		CCCATCTGTCGTGGGCAGTCT	0.667000													16	74					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225591013	225591013	+	Missense_Mutation	SNP	T	T	C			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:225591013T>C	ENST00000338179.2	-	14	1965	c.1840A>G	c.(1840-1842)Atc>Gtc	p.I614V	LBR_ENST00000272163.4_Missense_Mutation_p.I614V	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	614					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		CATTAGTAGATGTATGGAAAT	0.433000													9	112					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92671666	92671666	+	Missense_Mutation	SNP	G	G	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr15:92671666G>A	ENST00000318445.6	+	7	1673	c.1459G>A	c.(1459-1461)Ggg>Agg	p.G487R	SLCO3A1_ENST00000555549.1_3'UTR|SLCO3A1_ENST00000424469.2_Missense_Mutation_p.G487R	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	487	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TCCAGTGTGTGGGGCAGATGG	0.562000													3	150					0	0	1	0	0
PCDHGB1	0	broad.mit.edu	37	5	140729950	140729950	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr5:140729950C>T	ENST00000523390.1	+	1	123	c.123C>T	c.(121-123)aaC>aaT	p.N41N	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTAGCCAACGGCTCACGGG	0.522000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	20					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67205385	67205385	+	Silent	SNP	C	C	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr13:67205385C>T	ENST00000544246.1	-	4	3988	c.3297G>A	c.(3295-3297)ccG>ccA	p.P1099P	PCDH9_ENST00000456367.1_Silent_p.P1065P|PCDH9_ENST00000377865.2_Silent_p.P1099P|PCDH9_ENST00000328454.5_Silent_p.P1065P	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1099					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCCTCTTGTCCGGAGAGGCCT	0.512000													7	116					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16957305	16957306	+	RNA	INS	-	-	C	rs139092192	by1000genomes	TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:16957305_16957306insC	ENST00000412962.1	-	0	294																											CCCCAGACACGCCCCCACCCCC	0.663													3	3	---	---	---	---					
ZNF644	84146	broad.mit.edu	37	1	91406039	91406040	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:91406039_91406040insT	ENST00000370440.1	-	3	1088_1089	c.871_872insA	c.(871-873)aaafs	p.K291fs	ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000337393.5_Frame_Shift_Ins_p.K291fs			Q9H582	ZN644_HUMAN	zinc finger protein 644	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTTTCGCTTTCTTTTTTTTTCT	0.337													7	54	---	---	---	---					
SMG7	9887	broad.mit.edu	37	1	183515266	183515267	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr1:183515266_183515267insA	ENST00000367537.3	+	18	2680_2681	c.2485_2486insA	c.(2485-2487)aaafs	p.K829fs	SMG7_ENST00000347615.2_Frame_Shift_Ins_p.K846fs|SMG7_ENST00000515829.2_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000507469.1_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000508461.1_Frame_Shift_Ins_p.K804fs|SMG7_ENST00000456731.2_Frame_Shift_Ins_p.K758fs			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	846	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding	p.?(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						GCAGCCTCTAGAAAAAAAAATG	0.450													7	67	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98382597	98382597	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:98382597delG	ENST00000186436.5	-	35	4931	c.4703delC	c.(4702-4704)cafs	p.P1568fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1568						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TTTGTGAACTGGAACGGAATC	0.512													20	49	---	---	---	---					
C2orf82	389084	broad.mit.edu	37	2	233740763	233740763	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr2:233740763delC	ENST00000409230.1	+	3	434	c.187delC	c.(187-189)ccfs	p.P64fs	C2orf82_ENST00000409533.1_Frame_Shift_Del_p.P64fs|C2orf82_ENST00000331342.2_Frame_Shift_Del_p.P64fs			Q6UX34	CB082_HUMAN	chromosome 2 open reading frame 82	64						integral to membrane											GGACACCGGTCCCCCAGCCCC	0.781													2	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100388502	100388502	+	RNA	DEL	A	A	-	rs5886138		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr7:100388502delA	ENST00000542585.1	+	0	7502				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			aagactgtctaaaaaaaaaaa	0.522													3	4	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283605	43283606	+	RNA	INS	-	-	A			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr11:43283605_43283606insA	ENST00000511537.1	-	0	1329_1330					NR_033868.1																						GAAGCAAATGTAAAAAAAAAAA	0.386													3	6	---	---	---	---					
RP11-551L14.1	0	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													5	3	---	---	---	---					
GLTSCR1	29998	broad.mit.edu	37	19	48204803	48204805	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr19:48204803_48204805delTCC	ENST00000396720.3	+	15	4008_4010	c.3814_3816delTCC	c.(3814-3816)del	p.S1276del	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1276	Poly-Ser.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		gtcctcctcttcctcctcctcct	0.719													2	4	---	---	---	---					
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Frame_Shift_Del	DEL	T	T	-	rs77187934		TCGA-HI-7169-01A-11D-2114-08	TCGA-HI-7169-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1fc4226-40ce-43b7-b92e-aa7cecd0cf4d	263e1015-1061-4ad2-8f7e-ed430d2d9e80	g.chr19:52877717delT	ENST00000597976.1	+	3	325	c.305delT	c.(304-306)atfs	p.I102fs	ZNF880_ENST00000422689.2_Intron|ZNF880_ENST00000344085.5_Intron|ZNF880_ENST00000600321.1_Intron|ZNF880_ENST00000424032.2_Intron			Q6PDB4	ZN880_HUMAN	zinc finger protein 880	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						GGCCCCATAAttttttttttt	0.473													2	4	---	---	---	---