Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCAF8	22828	broad.mit.edu	37	6	155114092	155114092	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr6:155114092G>C	ENST00000367178.3	+	5	1033	c.457G>C	c.(457-459)Gct>Cct	p.A153P	SCAF8_ENST00000417268.1_Missense_Mutation_p.A153P|SCAF8_ENST00000367186.4_Missense_Mutation_p.A219P	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	153					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						CACTACCACTGCTATGAGCAA	0.378000													5	15					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67685883	67685883	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr16:67685883C>T	ENST00000334583.6	+	26	2976	c.2648C>T	c.(2647-2649)gCa>gTa	p.A883V	RLTPR_ENST00000545661.1_Missense_Mutation_p.A847V	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	883										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CAGGCTTTGGCAGGCCTGAGT	0.587000													5	113					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128658068	128658068	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr7:128658068G>C	ENST00000393245.1	-	2	637	c.264C>G	c.(262-264)gaC>gaG	p.D88E	TNPO3_ENST00000471166.1_Missense_Mutation_p.D88E|TNPO3_ENST00000265388.5_Missense_Mutation_p.D88E|TNPO3_ENST00000471234.1_Missense_Mutation_p.D88E|TNPO3_ENST00000482320.1_Missense_Mutation_p.D22E	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	88					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						TTAGCAATGAGTCCCGTAAAG	0.418000													4	57					0	0	1	0	0
DNAJC19	131118	broad.mit.edu	37	3	180703757	180703757	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr3:180703757T>G	ENST00000382564.2	-	5	407	c.237A>C	c.(235-237)agA>agC	p.R79S	DNAJC19_ENST00000486355.1_3'UTR|DNAJC19_ENST00000479269.1_Missense_Mutation_p.R54S|DNAJC19_ENST00000491873.1_Missense_Mutation_p.R54S	NM_145261.3	NP_660304.1	Q96DA6	TIM14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 19	79	J.				genitalia development|protein folding|protein targeting to mitochondrion|transmembrane transport|visual perception	integral to membrane|mitochondrial inner membrane	heat shock protein binding			large_intestine(2)|lung(1)	3	all_cancers(143;3.12e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-36)|OV - Ovarian serous cystadenocarcinoma(80;1.55e-22)			GATGAGCATCTCTTATTTTCC	0.338000													12	19					0	0	1	0	0
PAX5	5079	broad.mit.edu	37	9	37006485	37006485	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr9:37006485A>G	ENST00000358127.4	-	4	534	c.460T>C	c.(460-462)Tcc>Ccc	p.S154P	PAX5_ENST00000377853.2_Missense_Mutation_p.S154P|PAX5_ENST00000414447.1_Missense_Mutation_p.S154P|PAX5_ENST00000522003.1_Missense_Mutation_p.S46P|PAX5_ENST00000520154.1_Missense_Mutation_p.S154P|RP11-297B17.3_ENST00000509911.2_RNA|PAX5_ENST00000520281.1_Missense_Mutation_p.S154P|PAX5_ENST00000377847.2_Missense_Mutation_p.S154P|PAX5_ENST00000446742.1_Missense_Mutation_p.S88P|PAX5_ENST00000523145.1_Missense_Mutation_p.S46P|PAX5_ENST00000523241.1_Missense_Mutation_p.S154P|PAX5_ENST00000377852.2_Missense_Mutation_p.S154P	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	154					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(40)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTGTGACTGGAAGCTGGGACT	0.378000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								43	50					0	0	1	0	0
NKD2	85409	broad.mit.edu	37	5	1038080	1038080	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:1038080C>T	ENST00000296849.5	+	10	1177	c.948C>T	c.(946-948)gcC>gcT	p.A316A	NKD2_ENST00000274150.4_3'UTR|NKD2_ENST00000382730.2_Intron	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	316	Interaction with TGFA.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CTGCCCGGGCCCTGGACACGC	0.697000													3	6					0	0	1	0	0
PCDHA8	0	broad.mit.edu	37	5	140223018	140223018	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:140223018C>G	ENST00000531613.1	+	1	2112	c.2112C>G	c.(2110-2112)atC>atG	p.I704M	PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.I704M	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCGCCATCTGCGCGGTAT	0.657000													11	49					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													3	31					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50805733	50805733	+	Silent	SNP	A	A	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr6:50805733A>G	ENST00000263046.4	+	6	1060	c.894A>G	c.(892-894)gaA>gaG	p.E298E	TFAP2B_ENST00000393655.3_Silent_p.E289E			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	289					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					AAAGGCTAGAAAAAATCGGTT	0.453000													28	69					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28844930	28844930	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr13:28844930C>G	ENST00000399613.1	+	12	1348	c.1285C>G	c.(1285-1287)Cgt>Ggt	p.R429G	PAN3_ENST00000380958.3_Missense_Mutation_p.R629G|PAN3_ENST00000282391.5_Missense_Mutation_p.R317G			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	629	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TTCTGCATTGCGTACCATTCA	0.428000													28	93					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146080671	146080671	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:146080671C>T	ENST00000394413.3	-	2	675	c.105G>A	c.(103-105)acG>acA	p.T35T	PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Silent_p.T24T|PPP2R2B_ENST00000453001.1_Silent_p.T35T|PPP2R2B_ENST00000394411.4_Silent_p.T35T|PPP2R2B_ENST00000504198.1_Silent_p.T41T|PPP2R2B_ENST00000394414.1_Silent_p.T101T|PPP2R2B_ENST00000336640.6_Silent_p.T38T|PPP2R2B_ENST00000394409.3_Silent_p.T93T|PPP2R2B_ENST00000508545.2_Silent_p.T24T|PPP2R2B_ENST00000356826.3_Silent_p.T35T			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	35					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTAATTCTCCCGTGTGGTTGA	0.423000													8	302					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19474542	19474542	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr1:19474542G>C	ENST00000375267.2	-	51	7577	c.7574C>G	c.(7573-7575)tCc>tGc	p.S2525C	UBR4_ENST00000375217.2_Missense_Mutation_p.S2525C|UBR4_ENST00000375226.2_Missense_Mutation_p.S2536C|UBR4_ENST00000375254.3_Missense_Mutation_p.S2525C			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2525					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AAGGCTCTTGGACTGCTGCTG	0.567000													9	34					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	47					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													4	26					0	0	1	0	0
TBC1D3	729873	broad.mit.edu	37	17	36352489	36352489	+	Translation_Start_Site	SNP	A	A	C	rs4796259	by1000genomes	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr17:36352489A>C	ENST00000537432.1	-	0	359				RP11-1407O15.2_ENST00000312412.4_Missense_Mutation_p.F433C|RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.F278C			Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3							intracellular	Rab GTPase activator activity			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATAGCATCAAATATCTCATC	0.388000													3	29					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170876179	170876179	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:170876179C>T	ENST00000274625.5	+	4	823	c.279C>T	c.(277-279)ttC>ttT	p.F93F		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	93					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGACACCTTCGGTAGTCAAG	0.517000													5	41					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	114002103	114002103	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr2:114002103C>T	ENST00000429538.3	-	4	484	c.290G>A	c.(289-291)cGc>cAc	p.R97H	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000422956.1_RNA|AC016683.6_ENST00000553869.2_RNA|PAX8_ENST00000263334.5_Missense_Mutation_p.R97H|PAX8_ENST00000348715.5_Missense_Mutation_p.R97H|AC016683.6_ENST00000556070.1_RNA|PAX8_ENST00000263335.7_Missense_Mutation_p.R97H|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.R97H	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	97	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						AGGGTTCTGGCGTTTGTAGTC	0.587000			T	PPARG	follicular thyroid		Thyroid dysgenesis						7	240					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190122701	190122701	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr3:190122701C>T	ENST00000264734.2	+	3	826	c.578C>T	c.(577-579)aCg>aTg	p.T193M	CLDN16_ENST00000456423.1_Intron|CLDN16_ENST00000468220.1_3'UTR	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	193					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		GCTGGAGCCACGTTACTAATA	0.527000													15	47					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119575758	119575758	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr1:119575758C>T	ENST00000235521.4	-	6	885	c.859G>A	c.(859-861)Gtg>Atg	p.V287M	WARS2_ENST00000537870.1_Missense_Mutation_p.V193M|WARS2_ENST00000369426.5_3'UTR	NM_015836.3|NM_201263.2	NP_056651.1|NP_957715.1	Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	287					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	ACTTCCTCCACGGAGAGCCCC	0.627000													6	84					0	0	1	0	0
CHEK2P2	0	broad.mit.edu	37	15	20496765	20496765	+	RNA	SNP	G	G	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr15:20496765G>T	ENST00000555186.1	+	0	818					NR_038836.1																						GTTTTTTATAGTGTGTATTTT	0.358000													5	21					1.23904e-05	1.28034e-05	1	1	0
GABRA6	2559	broad.mit.edu	37	5	161119058	161119058	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:161119058T>G	ENST00000523217.1	+	8	1150	c.908T>G	c.(907-909)tTc>tGc	p.F303C	GABRA6_ENST00000274545.5_Missense_Mutation_p.F313C	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	313					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGCTTTGCATTCGTCTTCTCT	0.478000										TCGA Ovarian(5;0.080)			4	90					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21245111	21245111	+	Splice_Site	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr13:21245111G>A	ENST00000382778.4	+	26	3444		c.e26-1		IFT88_ENST00000351808.5_Splice_Site|IFT88_ENST00000319980.6_Splice_Site|IFT88_ENST00000537103.1_Splice_Site			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)						cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CTTTGCTCTAGCGCATAAAGT	0.393000													4	17					0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89790855	89790855	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr6:89790855G>A	ENST00000336032.3	+	1	359	c.242G>A	c.(241-243)cGc>cAc	p.R81H	PNRC1_ENST00000369472.1_Intron	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CTGCCCAACCGCAGCCTCGCC	0.716000										Multiple Myeloma(7;0.094)			5	7					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350298	100350298	+	RNA	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr7:100350298C>T	ENST00000542585.1	+	0	2718				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACAGAAAAACCCACCATCCCC	0.498000													4	121					0	0	1	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026005	129026005	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr2:129026005G>A	ENST00000259241.6	-	2	980	c.967C>T	c.(967-969)Cgg>Tgg	p.R323W		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	323					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CCGCCCGCCCGCGTGCTATTG	0.597000													8	22					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													4	81					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													7	46					0.00307968	0.00307968	1	1	0
AC008103.5	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													4	8					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088094	9088094	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr19:9088094T>A	ENST00000397910.4	-	1	3924	c.3721A>T	c.(3721-3723)Acc>Tcc	p.T1241S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1241	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGGGTAGGTGCTGAGGGTT	0.507000													5	277					0	0	1	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr21:44524456G>A	ENST00000291552.4	-	2	193	c.101C>T	c.(100-102)tCt>tTt	p.S34F	U2AF1_ENST00000459639.1_5'UTR|U2AF1_ENST00000398137.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.S34F|U2AF1_ENST00000486519.1_5'UTR	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	34					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.S34F(45)|p.S34Y(12)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GTGCAACCGAGAGCACCTGTC	0.358000			Mis		"""CLL, MDS"""								8	24					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65551824	65551824	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr15:65551824A>T	ENST00000261888.6	-	6	1338	c.893T>A	c.(892-894)cTg>cAg	p.L298Q	PARP16_ENST00000444347.2_Missense_Mutation_p.L182Q	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	297	Poly-Leu.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						CAGCAGATACAGGGATATCAT	0.473000													6	56					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207436508	207436508	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr2:207436508G>A	ENST00000264377.3	+	17	1952	c.1624G>A	c.(1624-1626)Gac>Aac	p.D542N	ADAM23_ENST00000374416.1_Missense_Mutation_p.D542N|ADAM23_ENST00000374415.3_Missense_Mutation_p.D542N	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	542	Disintegrin.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TCACTGCAGCGACGGGCCCTG	0.443000													11	24					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18844888	18844888	+	RNA	SNP	A	A	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:18844888A>G	ENST00000412938.1	+	0	3138																											GCTCACGGAAATACAGCTTCA	0.587000													5	26					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62295522	62295522	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr11:62295522C>T	ENST00000378024.4	-	5	6641	c.6367G>A	c.(6367-6369)Gac>Aac	p.D2123N	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2123					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AAGTGTAAGTCCACATCAGGC	0.522000													6	272					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	47					0.00024832	0.000252391	1	1	0
ZNF710	374655	broad.mit.edu	37	15	90610702	90610702	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr15:90610702C>T	ENST00000268154.4	+	2	584	c.333C>T	c.(331-333)ttC>ttT	p.F111F		NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			AGGTCAAGTTCGAGAAGGTGG	0.657000													3	14					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													4	27					0	0	1	0	0
PCDHGA7	0	broad.mit.edu	37	5	140764756	140764756	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr5:140764756C>T	ENST00000518325.1	+	1	2290	c.2290C>T	c.(2290-2292)Cgg>Tgg	p.R764W	PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGACTCTCGGAAGAGTCA	0.542000													30	100					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5139146	5139146	+	Missense_Mutation	SNP	C	C	T	rs147678499	byFrequency	TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr16:5139146C>T	ENST00000427587.4	-	7	922	c.854G>A	c.(853-855)cGc>cAc	p.R285H	FAM86A_ENST00000458008.4_Missense_Mutation_p.R251H|FAM86A_ENST00000587133.1_Missense_Mutation_p.R224H	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	285										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						CTCTGGGTTGCGGACGGTAAA	0.677000													5	99					0	0	1	0	0
TGIF2LY	90655	broad.mit.edu	37	Y	3447294	3447294	+	Silent	SNP	C	C	G			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chrY:3447294C>G	ENST00000559055.2	+	1	139	c.9C>G	c.(7-9)gcC>gcG	p.A3A	TGIF2LY_ENST00000321217.4_Silent_p.A3A			Q8IUE0	TF2LY_HUMAN	TGFB-induced factor homeobox 2-like, Y-linked	3						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|upper_aerodigestive_tract(1)	2						ATATGGAGGCCGCTGCAGACG	0.507000													4	10					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287807	122287807	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr3:122287807C>T	ENST00000296161.4	+	3	1060	c.871C>T	c.(871-873)Cgt>Tgt	p.R291C	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	291					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GGAAGCAGCTCGTGAGTCTTT	0.403000													21	43					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15705570	15705570	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr16:15705570G>A	ENST00000396368.3	-	18	3702	c.3496C>T	c.(3496-3498)Cgt>Tgt	p.R1166C	KIAA0430_ENST00000551742.1_Missense_Mutation_p.R1166C|KIAA0430_ENST00000548025.1_Missense_Mutation_p.R1163C|KIAA0430_ENST00000540441.2_Missense_Mutation_p.R1001C|KIAA0430_ENST00000602337.1_Missense_Mutation_p.R1163C|KIAA0430_ENST00000344181.3_Missense_Mutation_p.R768C	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1165						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						GTCAGCAGACGTTTGGAGCCC	0.478000													15	44					0	0	1	0	0
PICK1	9463	broad.mit.edu	37	22	38468599	38468599	+	Silent	SNP	T	T	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr22:38468599T>A	ENST00000404072.3	+	9	1019	c.672T>A	c.(670-672)ctT>ctA	p.L224L	PICK1_ENST00000356976.3_Silent_p.L224L|RP5-1039K5.13_ENST00000445483.1_RNA	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	224	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					GCATTCGGCTTCTGAAAACCA	0.597000													30	84					0	0	1	0	0
RSPH10B2	728194	broad.mit.edu	37	7	6797531	6797531	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr7:6797531G>C	ENST00000403107.1	+	2	610	c.223G>C	c.(223-225)Gag>Cag	p.E75Q	RSPH10B2_ENST00000359718.3_5'UTR|RSPH10B2_ENST00000297186.3_Missense_Mutation_p.E75Q|RSPH10B2_ENST00000404077.1_Missense_Mutation_p.E75Q|RSPH10B2_ENST00000433859.2_Missense_Mutation_p.E75Q					radial spoke head 10 homolog B2 (Chlamydomonas)											breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|skin(2)	15						CCAATACGAAGAGTCCATTCT	0.468000													44	209					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008203	65008203	+	Silent	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr14:65008203C>T	ENST00000247207.6	+	1	1018	c.636C>T	c.(634-636)atC>atT	p.I212I	HSPA2_ENST00000394709.1_Silent_p.I212I|HSPA2_ENST00000554883.1_3'UTR	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	212					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		ACGTGTCCATCCTGACCATCG	0.652000													4	63					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2077532	2077532	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr1:2077532G>C	ENST00000400921.2	+	4	753	c.70G>C	c.(70-72)Gag>Cag	p.E24Q	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Missense_Mutation_p.E24Q	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	207	OPR.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCTTCCTTCCGAGGAGACAGA	0.582000													5	27					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32632973	32632973	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr9:32632973C>T	ENST00000242310.4	-	1	2694	c.2605G>A	c.(2605-2607)Gct>Act	p.A869T		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	869					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.A869T(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTGAAGTCAGCGCAGAGCTTT	0.463000													4	152					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538401	63538401	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr7:63538401C>T	ENST00000550760.3	+	4	1153	c.974C>T	c.(973-975)tCg>tTg	p.S325L		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S325L(1)		endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						ATGTGGATCTCGGCCCTTAGT	0.403000													10	11					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80271468	80271468	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr14:80271468A>C	ENST00000281127.7	+	5	1802	c.923A>C	c.(922-924)gAt>gCt	p.D308A	NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000557594.1_Missense_Mutation_p.D308A|NRXN3_ENST00000428277.2_Missense_Mutation_p.D338A|NRXN3_ENST00000335750.5_Missense_Mutation_p.D940A|NRXN3_ENST00000554719.1_Missense_Mutation_p.D940A	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	308					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ACATCAGATGATCTTGTTTCA	0.388000													33	65					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66946227	66946227	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr16:66946227G>A	ENST00000299752.4	-	12	1659	c.1466C>T	c.(1465-1467)gCc>gTc	p.A489V	CDH16_ENST00000568632.1_Missense_Mutation_p.A392V|CDH16_ENST00000570262.1_Missense_Mutation_p.A409V|CDH16_ENST00000565796.1_Missense_Mutation_p.A489V|CDH16_ENST00000394055.3_Missense_Mutation_p.A489V	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	489	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCTCTCAATGGCAAAATCCAT	0.577000													3	58					0	0	1	0	0
FAM43B	163933	broad.mit.edu	37	1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr1:20880268_20880270delGAG	ENST00000332947.4	+	1	1337_1339	c.802_804delGAG	c.(802-804)del	p.E272del		NM_207334.2	NP_997217.1	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272										large_intestine(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.744													3	3	---	---	---	---					
RP11-93K22.13	0	broad.mit.edu	37	3	129811873	129811878	+	RNA	DEL	AAAAAA	AAAAAA	-	rs71158104		TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr3:129811873_129811878delAAAAAA	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							agtctgtcagaaaaaaaaaaaaaaaa	0.383													4	5	---	---	---	---					
LMOD2	442721	broad.mit.edu	37	7	123302916	123302918	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-G9-A9S7-01A-11D-A41K-08	TCGA-G9-A9S7-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e45d5e62-ce70-466d-b4b3-620d70c95651	0f1a5b46-d751-426a-917c-fac53a697f81	g.chr7:123302916_123302918delCCT	ENST00000458573.2	+	2	1433_1435	c.1276_1278delCCT	c.(1276-1278)del	p.P433del	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	433	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding										tcctcctccccctcctcctcctc	0.591													3	5	---	---	---	---