Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TVP23C-CDRT4	100533496	broad.mit.edu	37	17	15457141	15457141	+	Missense_Mutation	SNP	T	T	A			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr17:15457141T>A	ENST00000522212.2	-	3	210	c.98A>T	c.(97-99)cAt>cTt	p.H33L	TVP23C_ENST00000225576.3_Missense_Mutation_p.H33L|TVP23C_ENST00000519970.1_Intron|TVP23C_ENST00000438826.3_Missense_Mutation_p.H33L|TVP23C_ENST00000584811.1_5'UTR|TVP23C_ENST00000518321.1_Missense_Mutation_p.H33L|TVP23C_ENST00000428082.2_Missense_Mutation_p.H33L	NM_001204478.1	NP_001191407.1																					TGCTACTGGATGTCTGAAAAC	0.378000													32	75					0	0	1	0	0
RBP4	5950	broad.mit.edu	37	10	95360770	95360770	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr10:95360770C>T	ENST00000371467.1	-	2	335	c.16G>A	c.(16-18)Gcg>Acg	p.A6T	RBP4_ENST00000371464.3_Missense_Mutation_p.A6T|RBP4_ENST00000371469.2_Intron|FFAR4_ENST00000604414.1_Intron			P02753	RET4_HUMAN	retinol binding protein 4, plasma	6					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding			large_intestine(1)|lung(3)|skin(1)	5		Colorectal(252;0.122)			Vitamin A(DB00162)	AGCAAGAGCGCCCACACCCAC	0.697000													17	34					0	0	1	0	0
FAR2P1	440905	broad.mit.edu	37	2	130798070	130798070	+	RNA	SNP	T	T	C			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr2:130798070T>C	ENST00000325390.3	-	0	2340					NR_026758.1																						GGCCTTGCTATAGGTCTAAGT	0.473000													4	8					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													5	24					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2131703	2131703	+	Missense_Mutation	SNP	C	C	T	rs137854353		TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr16:2131703C>T	ENST00000219476.3	+	31	4348	c.3718C>T	c.(3718-3720)Cgc>Tgc	p.R1240C	TSC2_ENST00000350773.4_Missense_Mutation_p.R1240C|TSC2_ENST00000439673.2_Missense_Mutation_p.R1160C|TSC2_ENST00000401874.2_Missense_Mutation_p.R1196C|TSC2_ENST00000568454.1_Missense_Mutation_p.R1207C|TSC2_ENST00000353929.4_Missense_Mutation_p.R1197C|TSC2_ENST00000382538.6_Missense_Mutation_p.R1148C	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1240			R -> W (in TSC2).		cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GGCGGCTGAGCGCTTCAAGGA	0.627000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				4	54					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57908512	57908512	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr12:57908512G>A	ENST00000262027.5	+	16	2111	c.1977G>A	c.(1975-1977)atG>atA	p.M659I	MARS_ENST00000315473.5_Missense_Mutation_p.M425I	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	659					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	GAGCTGGGATGTTTGTGTCTA	0.507000													8	243					0	0	1	0	0
RBMX	27316	broad.mit.edu	37	X	135961213	135961213	+	Missense_Mutation	SNP	G	G	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chrX:135961213G>T	ENST00000562646.1	-	3	333	c.179C>A	c.(178-180)gCa>gAa	p.A60E	RBMX_ENST00000565438.1_Intron|RBMX_ENST00000320676.7_Missense_Mutation_p.A60E|RBMX_ENST00000570135.1_5'UTR|RBMX_ENST00000431446.3_Missense_Mutation_p.A60E			P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked	60	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					CTTAGCGTCTGCTGGGCTTTC	0.383000													4	103					0.150653	0.150653	1	1	0
DIRC2	84925	broad.mit.edu	37	3	122545710	122545710	+	Silent	SNP	A	A	G			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr3:122545710A>G	ENST00000261038.5	+	3	899	c.501A>G	c.(499-501)ccA>ccG	p.P167P		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	167					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		ATGCAGCACCATTTCTCTCTA	0.413000													10	68					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589813	140589813	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr5:140589813A>G	ENST00000239450.2	+	1	1523	c.1334A>G	c.(1333-1335)aAt>aGt	p.N445S	PCDHB12_ENST00000541609.1_Missense_Mutation_p.N108S	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		445	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGACGTCAATGACAACGCC	0.597000													6	81					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123663783	123663783	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chrX:123663783A>G	ENST00000422452.2	-	16	2765	c.2702T>C	c.(2701-2703)cTa>cCa	p.L901P	TENM1_ENST00000371130.3_Missense_Mutation_p.L901P	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CACTCCCACTAGAGGAGTTCC	0.473000													3	66					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542693	14542693	+	Silent	SNP	C	C	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr18:14542693C>T	ENST00000358970.5	-	1	452	c.453G>A	c.(451-453)aaG>aaA	p.K151K	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	151								p.K151K(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTCTGGGGACCTTACCCCACC	0.592000													4	107					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648781	62648781	+	Silent	SNP	T	T	C			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr10:62648781T>C	ENST00000337910.5	-	6	982	c.645A>G	c.(643-645)caA>caG	p.Q215Q	RHOBTB1_ENST00000357917.4_Silent_p.Q215Q	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	215					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					ATTTCCAGAATTGCAGGTGCC	0.478000													14	153					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655137	99655137	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr10:99655137G>A	ENST00000370597.3	-	11	1706	c.1351C>T	c.(1351-1353)Cgc>Tgc	p.R451C	CRTAC1_ENST00000370591.2_Missense_Mutation_p.R451C|CRTAC1_ENST00000298819.4_Missense_Mutation_p.R451C	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	451						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		AACCGGGTGCGTGGCACCACT	0.632000													20	23					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42132119	42132119	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr19:42132119C>T	ENST00000221954.2	-	2	390	c.280G>A	c.(280-282)Gca>Aca	p.A94T	CEACAM4_ENST00000600925.1_Missense_Mutation_p.A94T	NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	94	Ig-like V-type.					integral to plasma membrane|membrane fraction		p.A94T(1)		NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						CCACTGTATGCGGCCCCTGGG	0.488000													4	132					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261233	1261233	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr16:1261233T>C	ENST00000348261.5	+	22	4537	c.4289T>C	c.(4288-4290)aTt>aCt	p.I1430T	CACNA1H_ENST00000358590.4_Missense_Mutation_p.I1430T|CACNA1H_ENST00000565831.1_Missense_Mutation_p.I1430T	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1430					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTCAGGCCCATTGGGAACATC	0.602000													4	72					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	382547	382547	+	Silent	SNP	A	A	G	rs146408628		TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr3:382547A>G	ENST00000256509.2	+	6	1098	c.456A>G	c.(454-456)ccA>ccG	p.P152P	CHL1_ENST00000397491.2_Silent_p.P152P	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	152	Ig-like C2-type 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTGTCCTCCCATGCAATCCTC	0.383000													21	29					0	0	1	0	0
SUPT20H	55578	broad.mit.edu	37	13	37598536	37598536	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr13:37598536C>T	ENST00000360252.4	-	18	1623	c.1376G>A	c.(1375-1377)gGt>gAt	p.G459D	SUPT20H_ENST00000350612.6_Missense_Mutation_p.G458D|SUPT20H_ENST00000464744.1_Missense_Mutation_p.G459D|SUPT20H_ENST00000542180.1_Missense_Mutation_p.G422D|SUPT20H_ENST00000475892.1_Missense_Mutation_p.G458D|SUPT20H_ENST00000356185.3_Missense_Mutation_p.G459D	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		ATGTTTTACACCCTTCCCCAA	0.378000													4	39					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55338716	55338716	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr18:55338716G>C	ENST00000536015.1	-	17	2035	c.1916C>G	c.(1915-1917)aCa>aGa	p.T639R	RP11-35G9.5_ENST00000588925.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.T639R|RP11-35G9.3_ENST00000599199.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	639					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				GGCATCCTGTGTTTCTTGCTT	0.398000													23	56					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159647583	159647583	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr6:159647583C>T	ENST00000297267.9	+	9	1351	c.1151C>T	c.(1150-1152)gCg>gTg	p.A384V	FNDC1_ENST00000480856.1_3'UTR|FNDC1_ENST00000340366.6_Missense_Mutation_p.A384V	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	384	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TCTTGGGATGCGCTACCAGAG	0.473000													3	10					0	0	1	0	0
CHMP4B	128866	broad.mit.edu	37	20	32436406	32436406	+	Missense_Mutation	SNP	C	C	G			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr20:32436406C>G	ENST00000217402.2	+	2	489	c.324C>G	c.(322-324)aaC>aaG	p.N108K		NM_176812.4	NP_789782.1	Q9H444	CHM4B_HUMAN	charged multivesicular body protein 4B	108					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13						TGCTCAAGAACATGGGCTATG	0.602000													5	31					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34408631	34408631	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr10:34408631G>A	ENST00000374789.3	-	24	3912	c.3587C>T	c.(3586-3588)tCg>tTg	p.S1196L	PARD3_ENST00000545693.1_Missense_Mutation_p.S1180L|PARD3_ENST00000346874.4_Missense_Mutation_p.S1159L|PARD3_ENST00000545260.1_Missense_Mutation_p.S1106L|PARD3_ENST00000350537.4_Missense_Mutation_p.S1150L|PARD3_ENST00000374788.3_Missense_Mutation_p.S1193L|PARD3_ENST00000374790.3_Missense_Mutation_p.S1136L|PARD3_ENST00000374794.3_Missense_Mutation_p.S1084L	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1196					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CACGGACACCGAGTGTCGCCC	0.612000													10	22					0	0	1	0	0
TDGF1	6997	broad.mit.edu	37	3	46620740	46620740	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr3:46620740T>C	ENST00000296145.5	+	3	840	c.107T>C	c.(106-108)tTt>tCt	p.F36S	LRRC2_ENST00000296144.3_Intron|TDGF1_ENST00000542931.1_Missense_Mutation_p.F20S	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	36					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CATCAGGAATTTGCTCGTCCA	0.507000													9	47					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71491183	71491184	+	Frame_Shift_Ins	INS	-	-	CCTAC			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr5:71491183_71491184insCCTAC	ENST00000296755.7	+	5	2299_2300	c.2001_2002insCCTAC	c.(1999-2004)acctatfs	p.Y668fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	668	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGGACAAAACACCTATCAAGaa	0.366													4	9	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100369721	100369721	+	RNA	DEL	T	T	-			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr7:100369721delT	ENST00000542585.1	+	0	5573				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ctctaaattcttttttttttt	0.532													2	4	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65494020	65494021	+	In_Frame_Ins	INS	-	-	GCA	rs34265378		TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr8:65494020_65494021insGCA	ENST00000321870.1	+	1	1207_1208	c.673_674insGCA	c.(673-675)cag>GCAcag	p.224_225insA	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	224	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.S234delS(1)		NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						cggcagcggcggcagcagcagc	0.718													2	4	---	---	---	---					
NUTM2F	54754	broad.mit.edu	37	9	97080945	97080947	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr9:97080945_97080947delAGA	ENST00000253262.4	-	7	2091_2093	c.2071_2073delTCT	c.(2071-2073)del	p.S691del	NUTM2F_ENST00000335456.7_Intron|NUTM2F_ENST00000341207.4_In_Frame_Del_p.S676del	NM_017561.1	NP_060031.1			NUT family member 2F									p.S557delS(1)									TGCTGGCAGGAGAAGGTGATGGG	0.611													3	5	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													3	6	---	---	---	---					
FECH	2235	broad.mit.edu	37	18	55253811	55253811	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A81D-01A-11D-A35I-08	TCGA-WB-A81D-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82d05a53-ab4d-44e0-b2bf-94e0e80da830	fa630d71-91a2-4852-8728-fd3a2de4677c	g.chr18:55253811delG	ENST00000262093.5	-	1	193	c.42delC	c.(40-42)gcfs	p.A15fs	FECH_ENST00000585699.1_5'UTR|FECH_ENST00000382873.3_Frame_Shift_Del_p.A15fs	NM_000140.3|NM_001012515.2	NP_000131.2|NP_001012533.1	P22830	HEMH_HUMAN	ferrochelatase	15					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	15		Colorectal(73;0.227)				GGACGCCCGCGGCGCGCAGGG	0.756													2	4	---	---	---	---