Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPS6KA5	9252	broad.mit.edu	37	14	91338482	91338482	+	Missense_Mutation	SNP	G	G	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr14:91338482G>T	ENST00000261991.3	-	17	2518	c.2345C>A	c.(2344-2346)cCc>cAc	p.P782H	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.P703H	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	782					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AGGATTGCTGGGCTGCAGTGT	0.522000													80	39					5.72124e-26	6.02236e-26	1	1	0
PKN1	5585	broad.mit.edu	37	19	14574926	14574926	+	Silent	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr19:14574926G>A	ENST00000242783.6	+	12	1857	c.1692G>A	c.(1690-1692)caG>caA	p.Q564Q	PKN1_ENST00000342216.4_Silent_p.Q570Q	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	564					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						GCTCACCTCAGAAGAGCTCGC	0.647000													49	57					0	0	1	0	0
OLIG3	167826	broad.mit.edu	37	6	137814559	137814559	+	Missense_Mutation	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr6:137814559G>A	ENST00000367734.2	-	1	972	c.749C>T	c.(748-750)cCg>cTg	p.P250L		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	250	Poly-Pro.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GGACAGGTGCGGCGGCGGCGG	0.716000													7	6					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72868221	72868221	+	Silent	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:72868221G>A	ENST00000442102.2	-	2	203	c.117C>T	c.(115-117)ccC>ccT	p.P39P	FDXR_ENST00000413947.2_Silent_p.P70P|FDXR_ENST00000420580.2_Silent_p.P39P|FDXR_ENST00000581530.1_Silent_p.P39P|FDXR_ENST00000293195.5_Silent_p.P39P|FDXR_ENST00000582944.1_Silent_p.P39P|FDXR_ENST00000583917.1_Silent_p.P39P|FDXR_ENST00000455107.2_5'UTR	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	39					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					CACAGATCTGGGGGGTCTTCT	0.547000													11	22					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31581747	31581747	+	Missense_Mutation	SNP	T	T	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr14:31581747T>A	ENST00000399332.1	-	35	6641	c.6153A>T	c.(6151-6153)gaA>gaT	p.E2051D	HECTD1_ENST00000553700.1_Missense_Mutation_p.E2051D	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2051	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGCCAATGGTTCCTGCGAAT	0.378000													36	36					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520392	33520392	+	Missense_Mutation	SNP	G	G	C			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:33520392G>C	ENST00000297307.5	-	1	1020	c.935C>G	c.(934-936)gCg>gGg	p.A312G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	312	DUF6 2.					integral to membrane		p.A312G(4)									AACCCCTGCCGCCACGATGTC	0.567000													5	138					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274214	39274214	+	Missense_Mutation	SNP	G	G	C			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:39274214G>C	ENST00000391413.2	-	1	392	c.354C>G	c.(352-354)agC>agG	p.S118R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	118	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gtctgcagcagctggacacac	0.652000													6	46					0	0	1	0	0
BAG3	9531	broad.mit.edu	37	10	121436654	121436654	+	Missense_Mutation	SNP	G	G	A	rs144678100	byFrequency	TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr10:121436654G>A	ENST00000369085.3	+	4	1894	c.1588G>A	c.(1588-1590)Gtg>Atg	p.V530M		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	530					anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		GATGGGTGCCGTGGCAGCAGA	0.542000													4	92					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106082536	106082536	+	Splice_Site	SNP	A	A	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chrX:106082536A>G	ENST00000357242.5	+	8	1377		c.e8-1		TBC1D8B_ENST00000310452.2_Splice_Site|TBC1D8B_ENST00000276175.3_Intron	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTTCTTTTTCAGCTTGCTATT	0.363000													4	95					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12162226	12162226	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr10:12162226C>G	ENST00000263035.4	+	16	2680	c.2618C>G	c.(2617-2619)tCg>tGg	p.S873W		NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	873					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GGTCCGTGGTCGTTTGTTTCT	0.443000													78	100					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34622507	34622507	+	Missense_Mutation	SNP	G	G	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr9:34622507G>T	ENST00000378909.2	-	5	977	c.885C>A	c.(883-885)aaC>aaA	p.N295K		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	295	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CCAGACAAGGGTTTGGAATTC	0.572000													31	39					6.84511e-11	6.84511e-11	1	1	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971176	31971176	+	Silent	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr21:31971176G>A	ENST00000334897.3	-	1	43	c.18C>T	c.(16-18)taC>taT	p.Y6Y		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	6						intermediate filament				endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						AGTAGTTTCCGTAGTAGCTGC	0.522000													30	40					0	0	1	0	0
PRG2	5553	broad.mit.edu	37	11	57154992	57154992	+	Nonsense_Mutation	SNP	G	G	A	rs143145891		TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr11:57154992G>A	ENST00000311862.5	-	6	698	c.625C>T	c.(625-627)Cga>Tga	p.R209*	PRG2_ENST00000533605.1_Nonsense_Mutation_p.R198*|PRG2_ENST00000525955.1_Nonsense_Mutation_p.R209*	NM_001243245.1|NM_002728.4	NP_001230174.1|NP_002719.3			proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)											central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTGGGCTCGACGCCAGTGG	0.592000													52	33					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100904692	100904692	+	Silent	SNP	C	C	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr12:100904692C>T	ENST00000548884.1	+	4	757	c.216C>T	c.(214-216)ttC>ttT	p.F72F	NR1H4_ENST00000392986.3_Silent_p.F72F|NR1H4_ENST00000188403.7_Silent_p.F82F|NR1H4_ENST00000549996.1_Silent_p.F72F|NR1H4_ENST00000551379.1_Silent_p.F82F	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	82					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						ACCTGGGTTTCTACCCCCAGC	0.483000													34	48					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45440569	45440569	+	Silent	SNP	A	A	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr15:45440569A>G	ENST00000321429.4	+	22	3149	c.2742A>G	c.(2740-2742)gaA>gaG	p.E914E	DUOX1_ENST00000389037.3_Silent_p.E914E|DUOX1_ENST00000561166.1_Silent_p.E560E	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	914	EF-hand 3.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		ACAAGGAGGAACTGACATGGG	0.572000													4	75					0	0	1	0	0
TFR2	7036	broad.mit.edu	37	7	100238453	100238453	+	Missense_Mutation	SNP	G	G	A	rs139318596		TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr7:100238453G>A	ENST00000462107.1	-	4	616	c.329C>T	c.(328-330)gCg>gTg	p.A110V	TFR2_ENST00000431692.1_Missense_Mutation_p.A110V|TFR2_ENST00000223051.3_Missense_Mutation_p.A110V			Q9UP52	TFR2_HUMAN	transferrin receptor 2	110					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GTCTCCGCACGCCTGGCAGGA	0.592000													25	35					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99533880	99533880	+	Splice_Site	SNP	C	C	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr13:99533880C>T	ENST00000376460.1	-	25	2757	c.2675_splice	c.e25-1	p.V893_splice	DOCK9_ENST00000448493.2_Splice_Site_p.V905_splice|DOCK9_ENST00000339416.2_Splice_Site_p.V894_splice|DOCK9_ENST00000442173.1_Splice_Site_p.V893_splice	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	894					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGAATAATGACCCTACACACC	0.388000													3	8					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933259	43933259	+	Silent	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr20:43933259G>A	ENST00000537548.1	-	4	496	c.252C>T	c.(250-252)agC>agT	p.S84S	MATN4_ENST00000372754.1_Silent_p.S84S|MATN4_ENST00000372756.1_Silent_p.S84S|MATN4_ENST00000342716.4_Silent_p.S84S|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000360607.5_Silent_p.S84S|MATN4_ENST00000353917.5_Silent_p.S84S			O95460	MATN4_HUMAN	matrilin 4	84	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GAGGGAAGACGCTCTGCACTT	0.652000													23	26					0	0	1	0	0
PRKACB	5567	broad.mit.edu	37	1	84647929	84647929	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr1:84647929C>G	ENST00000370689.2	+	3	419	c.155C>G	c.(154-156)aCa>aGa	p.T52R	PRKACB_ENST00000470673.1_3'UTR|PRKACB_ENST00000370680.1_Missense_Mutation_p.T58R|PRKACB_ENST00000370685.3_Missense_Mutation_p.T99R|PRKACB_ENST00000394838.2_Missense_Mutation_p.T59R|PRKACB_ENST00000370688.3_Missense_Mutation_p.T52R|PRKACB_ENST00000370682.3_Missense_Mutation_p.T56R|PRKACB_ENST00000394839.2_Missense_Mutation_p.T55R	NM_001242862.1|NM_002731.2	NP_001229791.1|NP_002722.1	P22694	KAPCB_HUMAN	protein kinase, cAMP-dependent, catalytic, beta	52	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|lung(11)|ovary(1)	16				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		ACCCTTGGAACAGGTTCATTT	0.323000													41	8					0	0	1	0	0
GLOD4	51031	broad.mit.edu	37	17	680227	680227	+	Splice_Site	SNP	G	G	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:680227G>T	ENST00000301329.6	-	3	227	c.140_splice	c.e3-1	p.P48_splice	GLOD4_ENST00000301328.5_Splice_Site_p.P63_splice|GLOD4_ENST00000536578.1_Splice_Site_p.P39_splice	NM_016080.3	NP_057164.3	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	63						mitochondrion				endometrium(1)|large_intestine(1)|prostate(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCATCATAAGGCCTAGAAAAT	0.453000													35	38					2.20262e-25	2.2591e-25	1	1	0
UBR4	23352	broad.mit.edu	37	1	19481549	19481549	+	Silent	SNP	C	C	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr1:19481549C>G	ENST00000375267.2	-	44	6324	c.6321G>C	c.(6319-6321)gcG>gcC	p.A2107A	UBR4_ENST00000375226.2_Silent_p.A2107A|UBR4_ENST00000375217.2_Silent_p.A2107A|UBR4_ENST00000375254.3_Silent_p.A2107A			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2107					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CACCACCGCCCGCCACCTGGC	0.483000													36	58					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520358	33520358	+	Silent	SNP	A	A	G	rs74740601	by1000genomes	TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:33520358A>G	ENST00000297307.5	-	1	1054	c.969T>C	c.(967-969)atT>atC	p.I323I		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	323	DUF6 2.					integral to membrane		p.I323I(1)									TCTGGGCTGTAATGATGGCAA	0.547000													4	101					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	890943	890943	+	Missense_Mutation	SNP	T	T	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr10:890943T>G	ENST00000316157.3	-	5	523	c.483A>C	c.(481-483)aaA>aaC	p.K161N		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	161	HTH La-type RNA-binding.						nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						CCAATGTTTTTTTAAGTACTT	0.358000													44	47					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152883994	152883994	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr1:152883994A>G	ENST00000368764.3	+	2	1785	c.1721A>G	c.(1720-1722)cAg>cGg	p.Q574R	IVL_ENST00000392667.2_Missense_Mutation_p.Q428R			P07476	INVO_HUMAN	involucrin	574					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCAGCAGCAGAAGCAGGAG	0.567000													19	37					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23818383	23818383	+	Missense_Mutation	SNP	C	C	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr12:23818383C>A	ENST00000546136.1	-	6	889	c.887G>T	c.(886-888)gGa>gTa	p.G296V	SOX5_ENST00000545921.1_Missense_Mutation_p.G299V|SOX5_ENST00000451604.2_Missense_Mutation_p.G309V|SOX5_ENST00000541536.1_Missense_Mutation_p.G296V|SOX5_ENST00000381381.2_Missense_Mutation_p.G296V|SOX5_ENST00000537393.1_Missense_Mutation_p.G274V|SOX5_ENST00000309359.1_Missense_Mutation_p.G296V			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	309					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CTTACTACATCCAGCCTTATA	0.478000													95	118					3.82633e-55	4.13657e-55	1	1	0
NOP58	51602	broad.mit.edu	37	2	203155921	203155921	+	Silent	SNP	A	A	C			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr2:203155921A>C	ENST00000264279.5	+	8	934	c.708A>C	c.(706-708)gcA>gcC	p.A236A		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	236				KAAAEISMGTEVSEEDICNILHLCTQ -> EGSCRDIHGNR GFRRRYLQYSASLHP (in Ref. 6; AAF29084).	cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						AAGTGAAAGCAGCTGCAGAGA	0.433000													48	62					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364263	22364263	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr19:22364263T>C	ENST00000397121.2	-	3	573	c.256A>G	c.(256-258)Acc>Gcc	p.T86A		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCCACATTGGTACAACTAATT	0.338000													56	76					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7417036	7417036	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr17:7417036A>G	ENST00000322644.6	+	29	5852	c.5453A>G	c.(5452-5454)tAt>tGt	p.Y1818C		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1818	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				TCTCCAACCTATACCCCAAGC	0.582000													117	147					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608623	4608623	+	Missense_Mutation	SNP	G	G	C			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr11:4608623G>C	ENST00000312614.4	+	1	603	c.581G>C	c.(580-582)aGt>aCt	p.S194T		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGATGGTGAGTCATCTACCT	0.507000													50	42					0	0	1	0	0
EPOR	2057	broad.mit.edu	37	19	11492639	11492639	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr19:11492639G>A	ENST00000592375.2	-	3	498	c.394C>T	c.(394-396)Cga>Tga	p.R132*	EPOR_ENST00000222139.6_Nonsense_Mutation_p.R132*			P19235	EPOR_HUMAN	erythropoietin receptor	132						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CGGTGATATCGCGGAGCGCCG	0.617000											OREG0025255	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	27					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25775375	25775375	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr1:25775375delT	ENST00000374343.4	+	3	478	c.299delT	c.(298-300)ctfs	p.L100fs	TMEM57_ENST00000399763.3_Intron|TMEM57_ENST00000399766.3_Frame_Shift_Del_p.L100fs	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	100						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		ATACAGTGGCTTTTTTTTGCT	0.343													7	109	---	---	---	---					
SUSD4	55061	broad.mit.edu	37	1	223536702	223536703	+	In_Frame_Ins	INS	-	-	TGC	rs143929528	by1000genomes	TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr1:223536702_223536703insTGC	ENST00000343846.3	-	1	698_699	c.65_66insGCA	c.(64-66)ccc>cGCAcc	p.22_22P>RT	SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000366878.4_In_Frame_Ins_p.22_22P>RT|SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000344029.6_In_Frame_Ins_p.22_22P>RT|SUSD4_ENST00000366877.3_In_Frame_Ins_p.22_22P>RT|SUSD4_ENST00000342943.3_In_Frame_Ins_p.22_22P>RT			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	22						integral to membrane		p.Q22R(2)|p.Q22delQ(2)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GGGACTGAGGTtgctgctgctg	0.574													4	7	---	---	---	---					
SEMA3F	6405	broad.mit.edu	37	3	50212532	50212532	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr3:50212532delA	ENST00000002829.3	+	6	944	c.460delA	c.(460-462)cafs	p.T154fs	SEMA3F_ENST00000434342.1_Intron|SEMA3F_ENST00000413852.1_Intron	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	154	Sema.			Missing (in Ref. 2).	axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TTCTCAGGCCACACCATGGAC	0.687													2	4	---	---	---	---					
TMA16	55319	broad.mit.edu	37	4	164428219	164428219	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr4:164428219delA	ENST00000358572.5	+	2	379	c.38delA	c.(37-39)gafs	p.E13fs	TMA16_ENST00000513134.1_Frame_Shift_Del_p.E13fs|TMA16_ENST00000513272.1_Frame_Shift_Del_p.E13fs|TMA16_ENST00000508268.1_Frame_Shift_Del_p.E13fs|TMA16_ENST00000511562.1_3'UTR	NM_018352.2	NP_060822.2	Q96EY4	CD043_HUMAN	translation machinery associated 16 homolog (S. cerevisiae)	13																	GCAGGACGGGAAAAAAAAGTC	0.363													2	4	---	---	---	---					
EPC1	80314	broad.mit.edu	37	10	32581929	32581930	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr10:32581929_32581930insT	ENST00000319778.6	-	4	954_955	c.652_653insA	c.(652-654)gcafs	p.A218fs	EPC1_ENST00000263062.8_Frame_Shift_Ins_p.A218fs|EPC1_ENST00000375110.2_Frame_Shift_Ins_p.A168fs	NM_001272004.1|NM_001272019.1	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	218					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				TCGAGTCTGCATTTTTTCAGTA	0.322													33	39	---	---	---	---					
PTPN5	84867	broad.mit.edu	37	11	18764923	18764924	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr11:18764923_18764924insT	ENST00000358540.2	-	5	774_775	c.344_345insA	c.(343-345)agcfs	p.S115fs	PTPN5_ENST00000396168.1_Frame_Shift_Ins_p.S91fs|PTPN5_ENST00000396171.4_Frame_Shift_Ins_p.S115fs|PTPN5_ENST00000396170.1_Intron|PTPN5_ENST00000396167.2_Intron|PTPN5_ENST00000477854.1_5'UTR|PTPN5_ENST00000496201.2_5'UTR	NM_006906.1	NP_008837.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	115						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GGTTTGTGGCGTTCTGTGACCA	0.604													45	75	---	---	---	---					
GAS6	2621	broad.mit.edu	37	13	114550011	114550012	+	Frame_Shift_Ins	INS	-	-	TCCC			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr13:114550011_114550012insTCCC	ENST00000355761.4	-	1	44_45	c.45_46insGGGA	c.(43-48)gggtctfs	p.S16fs	GAS6_ENST00000327773.6_Intron|GAS6_ENST00000357389.3_Intron			Q14393	GAS6_HUMAN	growth arrest-specific 6	0					cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				GACAGCAGACATCCCGCTAGGG	0.614													4	6	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11049520	11049520	+	RNA	DEL	C	C	-			TCGA-QT-A5XJ-01A-11D-A35D-08	TCGA-QT-A5XJ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec08ec68-ebde-4429-93af-4578fc2fd8aa	e50d344a-a901-4193-81dc-d3697deedacf	g.chr21:11049520delC	ENST00000470054.1	-	0	588									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACCGCTGTATCCAGGCACATT	0.458													9	190	---	---	---	---