Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RNPEPL1	57140	broad.mit.edu	37	2	241513564	241513564	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:241513564A>G	ENST00000270357.3	+	5	873	c.280A>G	c.(280-282)Atc>Gtc	p.I94V		NM_018226.4	NP_060696.4	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like 1	94					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	13		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CTCCTTCCCCATCGTGGCCAT	0.627000													10	21					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61499249	61499249	+	Missense_Mutation	SNP	G	G	A	rs143701650	by1000genomes	TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr17:61499249G>A	ENST00000424789.2	+	25	5910	c.5906G>A	c.(5905-5907)cGa>cAa	p.R1969Q	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.R1979Q	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1969							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CAGCTGTCCCGAGACTCTCGG	0.532000													13	24					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798288	212798288	+	Silent	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr1:212798288C>T	ENST00000294829.3	+	1	500	c.69C>T	c.(67-69)acC>acT	p.T23T	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	23										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGTTCAACACCACCATGGGGA	0.488000													14	37					0	0	1	0	0
CFDP1	10428	broad.mit.edu	37	16	75446587	75446587	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr16:75446587T>C	ENST00000283882.3	-	3	380	c.248A>G	c.(247-249)gAg>gGg	p.E83G	RP11-77K12.1_ENST00000567194.1_Missense_Mutation_p.E140G|CFDP1_ENST00000564286.1_5'UTR	NM_006324.2	NP_006315.1	Q9UEE9	CFDP1_HUMAN	craniofacial development protein 1	83	Glu-rich.				multicellular organismal development					endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5						ACTGCTTCCCTCAGATTCTGA	0.493000													4	129					0	0	1	0	0
VSIG4	11326	broad.mit.edu	37	X	65242294	65242294	+	Silent	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chrX:65242294G>A	ENST00000374737.4	-	8	1119	c.1011C>T	c.(1009-1011)gcC>gcT	p.A337A	VSIG4_ENST00000412866.2_Silent_p.A243A|VSIG4_ENST00000455586.2_3'UTR	NM_001257403.1|NM_007268.2	NP_001244332.1|NP_009199.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	337					complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TTGCGAAGATGGCCACCCTCA	0.562000													10	18					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14479160	14479160	+	RNA	SNP	G	G	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr18:14479160G>C	ENST00000581457.1	-	0	748					NR_024076.1																						CAGATAGGTAGTTTCCCCTTT	0.493000													3	39					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743629	81743629	+	Missense_Mutation	SNP	G	G	A	rs148063041		TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr14:81743629G>A	ENST00000555447.1	-	6	2438	c.2026C>T	c.(2026-2028)Cgg>Tgg	p.R676W	STON2_ENST00000267540.2_Missense_Mutation_p.R676W	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	676	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GTCCTGAACCGCATTAGCTCA	0.537000													3	42					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16665777	16665777	+	Silent	SNP	T	T	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr17:16665777T>C	ENST00000443444.2	+	14	3957	c.3817T>C	c.(3817-3819)Ttg>Ctg	p.L1273L	CCDC144A_ENST00000456009.1_Silent_p.L1039L|RP11-219A15.1_ENST00000448331.3_Silent_p.L1273L|CCDC144A_ENST00000399273.1_Silent_p.L1273L|CCDC144A_ENST00000360524.8_Silent_p.L1273L			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	1273																	TAAAACCGAATTGGAAAGATA	0.333000													3	3					0	0	1	0	0
LGALS9C	654346	broad.mit.edu	37	17	18396088	18396088	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr17:18396088G>A	ENST00000328114.6	+	10	920	c.839G>A	c.(838-840)cGt>cAt	p.R280H	LGALS9C_ENST00000584941.1_Intron|LGALS9C_ENST00000583322.1_Missense_Mutation_p.R247H|LGALS9C_ENST00000581545.1_Intron|LGALS9C_ENST00000412421.2_Missense_Mutation_p.R192H	NM_001040078.2	NP_001035167.2	Q6DKI2	LEG9C_HUMAN	lectin, galactoside-binding, soluble, 9C	280	Galectin 2.						sugar binding			NS(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	7						GCTGTGGTCCGTAACACCCAG	0.587000													4	66					0	0	1	0	0
LGALS9B	284194	broad.mit.edu	37	17	20354879	20354879	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr17:20354879C>T	ENST00000423676.3	-	10	902	c.839G>A	c.(838-840)cGt>cAt	p.R280H	LGALS9B_ENST00000324290.5_Missense_Mutation_p.R279H			Q3B8N2	LEG9B_HUMAN	lectin, galactoside-binding, soluble, 9B	280	Galectin 2.						sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	10						CTGGGTGTTACGGACCACAGC	0.587000													14	19					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135188	27135188	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr7:27135188T>A	ENST00000343060.4	-	1	405	c.344A>T	c.(343-345)cAg>cTg	p.Q115L	HOXA1_ENST00000355633.5_Missense_Mutation_p.Q115L	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	115						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GTCTGCTTCCTGATTTAACGC	0.562000													3	66					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687217	21687217	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr20:21687217C>A	ENST00000398485.2	+	2	482	c.428C>A	c.(427-429)tCc>tAc	p.S143Y	PAX1_ENST00000460221.1_Intron|PAX1_ENST00000444366.2_Missense_Mutation_p.S119Y	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	143	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CTCCGCGTATCCCACGGCTGC	0.682000													19	22					8.00594e-06	8.00594e-06	1	1	0
MUC16	94025	broad.mit.edu	37	19	9075100	9075100	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr19:9075100C>T	ENST00000397910.4	-	3	12549	c.12346G>A	c.(12346-12348)Gcc>Acc	p.A4116T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4118	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCAGGAGGCTGTGGCTGAT	0.493000													8	38					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862645	10862645	+	RNA	SNP	G	G	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr21:10862645G>C	ENST00000559480.1	+	0	24																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GGAGGATCCTGTTTTTGGTGG	0.507000													4	283					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121002881	121002881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr12:121002881C>T	ENST00000325954.4	+	11	2133	c.1672C>T	c.(1672-1674)Cga>Tga	p.R558*	RNF10_ENST00000413266.2_Nonsense_Mutation_p.R563*	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	558					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTAGGATGTTCGACAGCGTCA	0.453000													42	67					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580901	40580901	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr19:40580901T>C	ENST00000450241.2	-	6	1657	c.1346A>G	c.(1345-1347)aAt>aGt	p.N449S	ZNF780A_ENST00000595687.2_Missense_Mutation_p.N483S|ZNF780A_ENST00000340963.5_Missense_Mutation_p.N483S|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000594395.1_Missense_Mutation_p.N484S|ZNF780A_ENST00000455521.1_Missense_Mutation_p.N484S|ZNF780A_ENST00000414720.2_Intron			O75290	Z780A_HUMAN	zinc finger protein 780A	483					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGAGCCACGATTGAAGGCCTT	0.423000													46	47					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								7	51					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118548121	118548121	+	Silent	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr1:118548121C>T	ENST00000336338.5	-	32	4757	c.4692G>A	c.(4690-4692)gaG>gaA	p.E1564E		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1564						cilium|flagellar axoneme|microtubule		p.E1564D(1)		NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTCGCAGCTGCTCACGCTTTT	0.443000													27	12					0	0	1	0	0
SUPT7L	9913	broad.mit.edu	37	2	27876404	27876404	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:27876404C>G	ENST00000337768.5	-	6	1762	c.1193G>C	c.(1192-1194)gGg>gCg	p.G398A	SUPT7L_ENST00000404798.2_Missense_Mutation_p.G263A|SUPT7L_ENST00000406540.1_Missense_Mutation_p.G396A|SUPT7L_ENST00000405491.1_Missense_Mutation_p.G396A|SUPT7L_ENST00000464789.2_Missense_Mutation_p.G396A	NM_014860.1	NP_055675.1	O94864	ST65G_HUMAN	suppressor of Ty 7 (S. cerevisiae)-like	398					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)					AGGGGAGGACCCCATGAGGCT	0.498000													19	28					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26165009	26165009	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr22:26165009G>A	ENST00000335473.7	+	4	1376	c.1126G>A	c.(1126-1128)Ggt>Agt	p.G376S	MYO18B_ENST00000407587.2_Missense_Mutation_p.G376S|MYO18B_ENST00000536101.1_Missense_Mutation_p.G376S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	376						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGAGAAAGCAGGTGAGCTTCG	0.572000													4	1					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238283663	238283663	+	Splice_Site	SNP	A	A	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:238283663A>T	ENST00000295550.4	-	8	3523	c.3070_splice	c.e8-1	p.V1024_splice	COL6A3_ENST00000472056.1_Splice_Site_p.V417_splice|COL6A3_ENST00000392004.3_Splice_Site_p.V818_splice|COL6A3_ENST00000347401.3_Splice_Site_p.V823_splice|COL6A3_ENST00000409809.1_Splice_Site_p.V818_splice|COL6A3_ENST00000392003.2_Splice_Site_p.V617_splice|COL6A3_ENST00000346358.4_Splice_Site_p.V824_splice|COL6A3_ENST00000353578.4_Splice_Site_p.V818_splice	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1024	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTCACCTGAAACTGGGAGGAG	0.522000													5	11					0	0	1	0	0
KRTAP12-3	386683	broad.mit.edu	37	21	46077965	46077965	+	Silent	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr21:46077965C>T	ENST00000397907.1	+	1	117	c.69C>T	c.(67-69)tcC>tcT	p.S23S	TSPEAR_ENST00000323084.4_Intron	NM_198697.2	NP_941970.2	P60328	KR123_HUMAN	keratin associated protein 12-3	23	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCCAGGCATCCTGCTATGTGC	0.672000													34	42					0	0	1	0	0
CDKL3	51265	broad.mit.edu	37	5	133648028	133648028	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr5:133648028T>C	ENST00000521118.1	-	7	950	c.836A>G	c.(835-837)gAt>gGt	p.D279G	CDKL3_ENST00000435211.1_Missense_Mutation_p.D279G|CDKL3_ENST00000518409.1_Intron|CDKL3_ENST00000435240.2_Intron|CDKL3_ENST00000536186.1_5'UTR|CDKL3_ENST00000523832.1_Missense_Mutation_p.D279G|CDKL3_ENST00000521755.1_Intron|CDKL3_ENST00000523054.1_Missense_Mutation_p.D90G|CDKL3_ENST00000265334.4_Missense_Mutation_p.D279G			Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3	279	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(3)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGCAAAAGATCACTAGATGA	0.328000													3	10					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100449	110100449	+	Silent	SNP	T	T	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr8:110100449T>C	ENST00000518632.1	+	2	1059	c.708T>C	c.(706-708)aaT>aaC	p.N236N	TRHR_ENST00000311762.2_Silent_p.N236N			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	236						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CATGGAAAAATGATTCAACCC	0.373000													13	20					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29225514	29225514	+	Silent	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:29225514C>T	ENST00000379558.4	+	5	891	c.540C>T	c.(538-540)agC>agT	p.S180S	FAM179A_ENST00000403861.2_Silent_p.S180S	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	180							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TCATCCAGAGCATCCCTACCA	0.662000													5	9					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44847335	44847335	+	Splice_Site	SNP	A	A	G			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr3:44847335A>G	ENST00000326047.4	+	16	1978		c.e16-1		KIF15_ENST00000425755.1_Splice_Site	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AATATCTATTAGGAAAAGGCA	0.343000													9	69					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46791574	46791574	+	Silent	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr11:46791574G>A	ENST00000529230.1	-	26	3307	c.3261C>T	c.(3259-3261)ccC>ccT	p.P1087P	CKAP5_ENST00000312055.5_Silent_p.P1087P|CKAP5_ENST00000354558.3_Silent_p.P1087P|CKAP5_ENST00000415402.1_Silent_p.P1087P			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1087					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TTGCTTTAGTGGGTGGAGCAG	0.448000													30	44					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	605191	605191	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr11:605191C>T	ENST00000264555.5	+	11	1353	c.1225C>T	c.(1225-1227)Ccg>Tcg	p.P409S	PHRF1_ENST00000413872.2_Missense_Mutation_p.P408S|PHRF1_ENST00000416188.2_Missense_Mutation_p.P409S|PHRF1_ENST00000533464.1_Missense_Mutation_p.P405S	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	409							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CAGCTGCATCCCGTCAGTGTT	0.557000													21	25					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54917726	54917726	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr12:54917726G>C	ENST00000293373.6	+	20	2221	c.2142G>C	c.(2140-2142)gaG>gaC	p.E714D	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E664D	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	714					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GCCACCTGGAGGCCAGACTCA	0.443000													18	34					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114354414	114354414	+	Silent	SNP	G	G	A	rs147797898		TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr1:114354414G>A	ENST00000261441.5	-	1	684	c.621C>T	c.(619-621)tgC>tgT	p.C207C		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	207						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATCGGTTCCGCAGGAGCTGG	0.632000													5	20					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237054510	237054510	+	Missense_Mutation	SNP	C	C	T	rs139771804		TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr1:237054510C>T	ENST00000366577.5	+	29	3479	c.3085C>T	c.(3085-3087)Cgg>Tgg	p.R1029W	MTR_ENST00000535889.1_Missense_Mutation_p.R978W	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	1029	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	ACTCCGGGCCCGGGGTGTGGT	0.522000													20	73					0	0	1	0	0
SLC44A1	23446	broad.mit.edu	37	9	108128699	108128699	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr9:108128699T>A	ENST00000374720.3	+	12	1730	c.1483T>A	c.(1483-1485)Tat>Aat	p.Y495N	SLC44A1_ENST00000374724.1_Missense_Mutation_p.Y495N|SLC44A1_ENST00000343170.7_Missense_Mutation_p.Y287N|SLC44A1_ENST00000374723.1_Missense_Mutation_p.Y495N	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	495						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	GTGCCTAAATTATTTAAATCA	0.299000													18	16					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61190752	61190752	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr14:61190752G>T	ENST00000216513.4	-	1	100	c.41C>A	c.(40-42)gCg>gAg	p.A14E		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	14						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		CTTGATGTCCGCCGCACTTGC	0.607000													23	42					4.59853e-10	4.70802e-10	1	1	0
PSG8	440533	broad.mit.edu	37	19	43262332	43262332	+	Silent	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr19:43262332G>A	ENST00000404209.4	-	3	627	c.531C>T	c.(529-531)agC>agT	p.S177S	PSG8_ENST00000401467.2_Intron|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000406636.3_Silent_p.S55S|PSG8_ENST00000306511.4_Silent_p.S177S	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	177	Ig-like C2-type 1.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				ACCACAGGTAGCTTGCGTCCG	0.527000													5	246					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36982171	36982171	+	Translation_Start_Site	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:36982171G>A	ENST00000497382.1	+	0	570				VIT_ENST00000457137.2_Missense_Mutation_p.R128Q|VIT_ENST00000404084.1_Missense_Mutation_p.R106Q|VIT_ENST00000379242.3_Missense_Mutation_p.R128Q|VIT_ENST00000379241.3_Missense_Mutation_p.R128Q|VIT_ENST00000389975.3_Missense_Mutation_p.R128Q|VIT_ENST00000401530.1_Missense_Mutation_p.R128Q			Q6UXI7	VITRN_HUMAN	vitrin							proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TCCCTACCACGATGGAGAGAA	0.443000													3	42					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43850691	43850691	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr20:43850691C>A	ENST00000372769.3	+	2	508	c.418C>A	c.(418-420)Caa>Aaa	p.Q140K		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	140	Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				TCATGGGACACAAAATCCTTC	0.388000													29	44					1.77063e-15	1.857e-15	1	1	0
SIX4	51804	broad.mit.edu	37	14	61190753	61190753	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr14:61190753C>T	ENST00000216513.4	-	1	99	c.40G>A	c.(40-42)Gcg>Acg	p.A14T		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	14						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		TTGATGTCCGCCGCACTTGCG	0.607000													22	42					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	55					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33113510	33113510	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr19:33113510C>G	ENST00000306065.4	-	18	1803	c.1645G>C	c.(1645-1647)Gtt>Ctt	p.V549L		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	549					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					TCGTAGTAAACCAGAGCCTTC	0.547000													3	57					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241702149	241702151	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr2:241702149_241702151delCTC	ENST00000498729.2	-	23	2347_2349	c.2101_2103delGAG	c.(2101-2103)del	p.E701del	KIF1A_ENST00000320389.7_In_Frame_Del_p.E692del	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	692					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CATCCTCGGGCTCCTCCTCCTCC	0.621													3	6	---	---	---	---					
RBPMS	11030	broad.mit.edu	37	8	30402178	30402180	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr8:30402178_30402180delCAC	ENST00000520191.1	+	6	683_685	c.253_255delCAC	c.(253-255)del	p.H86del	RBPMS_ENST00000320203.4_Intron|RBPMS_ENST00000287771.5_Intron|RBPMS_ENST00000397323.4_Intron|RBPMS_ENST00000520161.1_Intron|RBPMS_ENST00000519647.1_Intron|RBPMS_ENST00000517860.1_In_Frame_Del_p.H190del|RBPMS_ENST00000339877.4_Intron|RBPMS_ENST00000538486.1_Intron			Q93062	RBPMS_HUMAN	RNA binding protein with multiple splicing	0	RRM.				positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		TCACTCACTTCACCACCAGTCCT	0.502													27	30	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr12:133220099_133220100delCA	ENST00000320574.5	-	34	4380_4381	c.4337_4338delTG	c.(4336-4338)gfs	p.V1447fs	POLE_ENST00000535270.1_Frame_Shift_Del_p.V1420fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1447					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					7	168	---	---	---	---					
FAM155A	728215	broad.mit.edu	37	13	108518687	108518689	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr13:108518687_108518689delCTG	ENST00000375915.2	-	1	394_396	c.256_258delCAG	c.(256-258)del	p.Q86del		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	86	Poly-Gln.					integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						gccgctgcctctgctgctgctgc	0.719													7	26	---	---	---	---					
LOC645752	645752	broad.mit.edu	37	15	78217568	78217569	+	RNA	INS	-	-	A			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr15:78217568_78217569insA	ENST00000567226.1	-	0	105																											ATATTATGGCTAAAAAAAAAGT	0.426													2	4	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	81973	81974	+	RNA	INS	-	-	GTCC			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr16:81973_81974insGTCC	ENST00000568710.1	-	0	349																											ATCAGCAGGAGGCCCACCTCGT	0.614													4	5	---	---	---	---					
MYH14	79784	broad.mit.edu	37	19	50771562	50771564	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-QR-A70P-01A-11D-A35D-08	TCGA-QR-A70P-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	857459e5-c09d-4ae3-b2e6-f7945e943573	b41e573f-9738-41d3-b8b4-94dc2b98514d	g.chr19:50771562_50771564delGAG	ENST00000440075.2	+	24	3018_3020	c.2971_2973delGAG	c.(2971-2973)del	p.E994del	MYH14_ENST00000262269.8_In_Frame_Del_p.E994del|MYH14_ENST00000376970.2_In_Frame_Del_p.E986del|MYH14_ENST00000601313.1_In_Frame_Del_p.E994del|MYH14_ENST00000598205.1_In_Frame_Del_p.E961del|MYH14_ENST00000596571.1_In_Frame_Del_p.E953del|MYH14_ENST00000425460.1_In_Frame_Del_p.E961del			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	953					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TCGCGTGGGCGAGGAGGAGGAGT	0.655													2	4	---	---	---	---