Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNM1P47	100216544	broad.mit.edu	37	15	102292770	102292770	+	RNA	SNP	C	C	T	rs149751844	by1000genomes	TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr15:102292770C>T	ENST00000561463.1	+	0	816																											AGCGGCGCGACGAGATGCTGC	0.597000													3	22					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714144	70714144	+	RNA	SNP	A	A	G	rs111296958	by1000genomes	TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr14:70714144A>G	ENST00000530196.1	-	0	374					NR_003951.1																						AGAGCTTCTTAACCCTCATAT	0.502000													5	75					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185892705	185892705	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr1:185892705T>G	ENST00000271588.4	+	8	1434	c.1205T>G	c.(1204-1206)tTt>tGt	p.F402C	HMCN1_ENST00000367492.2_Missense_Mutation_p.F402C	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	402					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GAAGCTTTCTTTCTCAAAGTA	0.353000													9	67					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440293	40440293	+	Silent	SNP	C	C	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr4:40440293C>T	ENST00000319592.4	-	4	1327	c.618G>A	c.(616-618)gcG>gcA	p.A206A	RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Silent_p.A206A|RBM47_ENST00000381793.2_Silent_p.A206A|RBM47_ENST00000295971.7_Silent_p.A206A|RBM47_ENST00000514014.1_Silent_p.A168A			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	206	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CCATGGCAGCCGCGCGGTGGC	0.672000													4	37					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52714802	52714802	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr12:52714802G>T	ENST00000293670.3	-	1	380	c.318C>A	c.(316-318)tgC>tgA	p.C106*		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	106	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CCTGCTTCACGCACTGCGCGT	0.617000													5	159					3.59834e-05	3.8465e-05	1	1	0
NAPB	63908	broad.mit.edu	37	20	23375633	23375633	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr20:23375633T>A	ENST00000377026.4	-	5	431	c.346A>T	c.(346-348)Agg>Tgg	p.R116W	NAPB_ENST00000472855.1_5'UTR|NAPB_ENST00000432543.2_Missense_Mutation_p.R77W|NAPB_ENST00000398425.3_Missense_Mutation_p.R22W	NM_022080.2	NP_071363.1	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, beta	116					intracellular protein transport|vesicle-mediated transport	membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					ATTGTAAACCTTCCCTAGGGG	0.413000													18	24					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	58273098	58273098	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr5:58273098G>T	ENST00000340635.6	-	12	1802	c.1627C>A	c.(1627-1629)Ctt>Att	p.L543I	PDE4D_ENST00000358923.6_Missense_Mutation_p.L241I|PDE4D_ENST00000502484.2_Missense_Mutation_p.L482I|PDE4D_ENST00000546160.1_Missense_Mutation_p.L482I|PDE4D_ENST00000405755.2_Missense_Mutation_p.L421I|PDE4D_ENST00000507116.1_Missense_Mutation_p.L479I|PDE4D_ENST00000360047.5_Missense_Mutation_p.L407I|PDE4D_ENST00000317118.8_Missense_Mutation_p.L252I|PDE4D_ENST00000503258.1_Missense_Mutation_p.L413I	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	543					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TCTTCCTGAAGCAATTTAAAG	0.368000													8	67					0.335167	0.335167	1	1	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													5	139					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71467156	71467156	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr4:71467156C>T	ENST00000322937.6	+	6	419	c.316C>T	c.(316-318)Cat>Tat	p.H106Y	AMBN_ENST00000449493.2_Intron	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	106					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			TTTGCCTGTGCATCCCCCACC	0.488000											OREG0016218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	108					0	0	1	0	0
GCHFR	2644	broad.mit.edu	37	15	41059517	41059517	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr15:41059517G>C	ENST00000558467.1	+	2	396	c.174G>C	c.(172-174)caG>caC	p.Q58H	GCHFR_ENST00000559932.1_Missense_Mutation_p.Q58H|GCHFR_ENST00000559445.1_Missense_Mutation_p.Q64H|GCHFR_ENST00000260447.4_Missense_Mutation_p.Q75H|GCHFR_ENST00000558670.1_3'UTR			P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulator	75					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				endometrium(2)|kidney(1)|large_intestine(1)|ovary(1)|prostate(1)	6		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GGGTGGGCCAGACGCTGGTGT	0.602000													29	48					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8242527	8242527	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr4:8242527A>G	ENST00000539824.1	+	18	4002	c.3628A>G	c.(3628-3630)Atc>Gtc	p.I1210V	SH3TC1_ENST00000245105.3_Missense_Mutation_p.I1286V			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	1286							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GCTGGCCACCATCTACCACAA	0.612000													5	34					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214546172	214546172	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr1:214546172C>G	ENST00000366956.5	-	16	3112	c.2918G>C	c.(2917-2919)gGc>gCc	p.G973A	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	973	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TTCTGCCCCGCCAACCACCAC	0.527000													4	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179398050	179398050	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr2:179398050G>A	ENST00000589042.1	-	358	103516	c.103292C>T	c.(103291-103293)aCg>aTg	p.T34431M	TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T31863M|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.T32790M|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T25366M|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T25491M|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T25558M|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32790							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAATAACCCGTGTCTTCAGG	0.488000													4	58					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49033855	49033855	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr15:49033855C>T	ENST00000380950.2	-	26	4223	c.4036G>A	c.(4036-4038)Gca>Aca	p.A1346T	CEP152_ENST00000399334.3_Missense_Mutation_p.A1290T|CEP152_ENST00000325747.5_Missense_Mutation_p.A1253T	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1290					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		AGTAATTTTGCCATTGTAGCA	0.353000													4	94					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327955	152327955	+	Silent	SNP	G	G	A			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr1:152327955G>A	ENST00000388718.5	-	3	2379	c.2307C>T	c.(2305-2307)agC>agT	p.S769S	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	769	Ser-rich.						calcium ion binding|structural molecule activity	p.S769S(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGGCCATAGCTAGACTGAC	0.517000													7	310					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606947	43606947	+	Silent	SNP	G	G	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr22:43606947G>T	ENST00000360835.3	-	18	2490	c.2364C>A	c.(2362-2364)acC>acA	p.T788T		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	788					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GTGTGACGTTGGTGGAGCCAT	0.642000													15	32					3.52763e-06	4.05024e-06	1	1	0
LOC100294341	100294341	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	19					0	0	1	0	0
GPR64	10149	broad.mit.edu	37	X	19027845	19027845	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chrX:19027845T>C	ENST00000354791.3	-	17	1514	c.1273A>G	c.(1273-1275)Ata>Gta	p.I425V	GPR64_ENST00000356606.4_Missense_Mutation_p.I427V|GPR64_ENST00000360279.4_Missense_Mutation_p.I419V|GPR64_ENST00000357544.3_Missense_Mutation_p.I411V|GPR64_ENST00000379869.3_Missense_Mutation_p.I441V|GPR64_ENST00000357991.3_Missense_Mutation_p.I438V|GPR64_ENST00000379873.2_Missense_Mutation_p.I441V|GPR64_ENST00000379876.1_Missense_Mutation_p.I417V|GPR64_ENST00000379878.3_Missense_Mutation_p.I425V|GPR64_ENST00000340581.3_Missense_Mutation_p.I411V			Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	441					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					GTTAGACTTATAGTCGTGTTT	0.393000													3	81					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29541604	29541604	+	Splice_Site	SNP	G	G	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr17:29541604G>T	ENST00000358273.4	+	13	1910		c.e13+1		NF1_ENST00000356175.3_Splice_Site|NF1_ENST00000431387.4_Splice_Site	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(5)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTTGCTTTGTGTAAGTATTTT	0.348000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			8	4					2.17888e-05	2.41233e-05	1	1	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	13					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58963019	58963019	+	Translation_Start_Site	SNP	G	G	A			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr19:58963019G>A	ENST00000391696.1	+	0	6				ZNF324B_ENST00000594214.1_De_novo_Start_OutOfFrame|ZNF324B_ENST00000545523.1_De_novo_Start_InFrame|ZNF324B_ENST00000336614.4_De_novo_Start_OutOfFrame			Q6AW86	Z324B_HUMAN	zinc finger protein 324B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGGCCACACCGGTGGTCTGGG	0.706000													8	31					0	0	1	0	0
FLJ16171	441116	broad.mit.edu	37	5	174353430	174353431	+	RNA	INS	-	-	A			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr5:174353430_174353431insA	ENST00000377300.3	-	0	1281					NR_046113.1																						AATTGCCAGCCAAAAAAAACCA	0.371													2	4	---	---	---	---					
CASP8AP2	9994	broad.mit.edu	37	6	90556397	90556398	+	RNA	INS	-	-	T			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr6:90556397_90556398insT	ENST00000551025.1	+	0	1492							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTCTAAtttccttttttttttt	0.421													2	4	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6662746	6662748	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr11:6662746_6662748delCAG	ENST00000299441.3	-	2	508_510	c.97_99delCTG	c.(97-99)del	p.L33del		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	33					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L33_G34insL(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCCAGCCCCcagcagcagcagc	0.635													4	6	---	---	---	---					
AATK	9625	broad.mit.edu	37	17	79104882	79104882	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QR-A6GS-01A-11D-A35D-08	TCGA-QR-A6GS-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	201e21fd-e02c-4ff3-80cf-47f0baa4d832	6834e654-4e2d-4f56-b649-c02cf7511ca7	g.chr17:79104882delC	ENST00000326724.4	-	3	337	c.313delG	c.(313-315)ccfs	p.A105fs	AATK_ENST00000417379.1_Frame_Shift_Del_p.A2fs	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	105						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGCTGCTTGGCCATGGGCAAG	0.711													2	4	---	---	---	---