Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANO6	196527	broad.mit.edu	37	12	45803201	45803201	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:45803201C>T	ENST00000320560.8	+	16	2144	c.1942C>T	c.(1942-1944)Cga>Tga	p.R648*	ANO6_ENST00000435642.1_Nonsense_Mutation_p.R648*|ANO6_ENST00000441606.2_Nonsense_Mutation_p.R630*|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000425752.2_Nonsense_Mutation_p.R648*|ANO6_ENST00000423947.3_Nonsense_Mutation_p.R669*	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	648					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GATAACCCCACGATGGGAACA	0.353000													160	332					0	0	0.870114	0	0
SLC9A3R2	9351	broad.mit.edu	37	16	2086466	2086466	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:2086466G>A	ENST00000424542.2	+	3	694	c.556G>A	c.(556-558)Gcc>Acc	p.A186T	SLC9A3R2_ENST00000432365.2_Missense_Mutation_p.A186T|SLC9A3R2_ENST00000566198.1_Missense_Mutation_p.A75T|SLC9A3R2_ENST00000565086.1_3'UTR|SLC9A3R2_ENST00000563587.1_Missense_Mutation_p.A80T	NM_001130012.2|NM_004785.5	NP_001123484.1|NP_004776.3	Q15599	NHRF2_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	186	PDZ 2.				protein complex assembly	apical plasma membrane|endomembrane system|nucleus	beta-catenin binding|phosphatase binding|protein C-terminus binding|receptor binding			central_nervous_system(1)|endometrium(1)	2						CTCACCTGCCGCCCGCTCTGG	0.697000													20	71					0	0	0.608945	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172204	207172204	+	Silent	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:207172204G>A	ENST00000374423.3	+	5	3338	c.2952G>A	c.(2950-2952)aaG>aaA	p.K984K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	984							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AAAGAGAAAAGCACGCTGAAT	0.398000													77	254					0	0	0.870114	0	0
PC	5091	broad.mit.edu	37	11	66637839	66637839	+	Silent	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:66637839G>A	ENST00000393960.1	-	9	1118	c.837C>T	c.(835-837)ccC>ccT	p.P279P	PC_ENST00000393958.2_Silent_p.P279P|PC_ENST00000355677.3_Silent_p.P279P|PC_ENST00000393955.2_Silent_p.P279P|PC_ENST00000524491.1_Silent_p.P239P	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	279	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGTGGGCGGCGGGGGCAATCT	0.637000													79	435					0	0	0.870114	0	0
PCDHGA11	0	broad.mit.edu	37	5	140800914	140800914	+	Silent	SNP	C	C	T	rs147068995	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:140800914C>T	ENST00000398587.2	+	1	153	c.120C>T	c.(118-120)acC>acT	p.T40T	PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000518882.1_Silent_p.T40T|PCDHGA5_ENST00000518069.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAAGAGACCGAAAAGGGCT	0.652000													119	200					0	0	0.870114	0	0
XIRP2	129446	broad.mit.edu	37	2	168099977	168099977	+	Missense_Mutation	SNP	T	T	C			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:168099977T>C	ENST00000409195.1	+	9	2164	c.2075T>C	c.(2074-2076)gTg>gCg	p.V692A	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.V692A|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.V470A|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	517					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTCAAGACTGTGAGATACATG	0.403000													70	250					0	0	0.870114	0	0
SLC22A11	55867	broad.mit.edu	37	11	64323727	64323727	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:64323727C>T	ENST00000301891.4	+	1	630	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C	SLC22A11_ENST00000377585.3_Missense_Mutation_p.R86C|SLC22A11_ENST00000377581.3_Missense_Mutation_p.R86C|SLC22A11_ENST00000490834.1_3'UTR	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	86					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	CCACCAGTGCCGCCGCTTCCG	0.652000											OREG0004031	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	271	696					0	0	0.870114	0	0
GAS2L2	246176	broad.mit.edu	37	17	34077157	34077157	+	Missense_Mutation	SNP	T	T	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:34077157T>G	ENST00000254466.6	-	2	593	c.566A>C	c.(565-567)gAc>gCc	p.D189A	GAS2L2_ENST00000587565.1_Intron	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	189					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CGGCGAGGGGTCGGGCGGGGG	0.741000													23	363					0	0	0.796494	0	0
CR2	1380	broad.mit.edu	37	1	207643052	207643052	+	Missense_Mutation	SNP	C	C	T	rs115418682	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr1:207643052C>T	ENST00000367057.3	+	6	1019	c.830C>T	c.(829-831)cCa>cTa	p.P277L	CR2_ENST00000458541.2_Missense_Mutation_p.P277L|CR2_ENST00000485707.1_3'UTR|CR2_ENST00000367059.3_Missense_Mutation_p.P277L|CR2_ENST00000367058.3_Missense_Mutation_p.P277L	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	277	Sushi 5.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ATTTTTTGCCCATCACCTCCC	0.428000													87	455					0	0	0.870114	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890639	32890639	+	RNA	SNP	T	T	C	rs79284655		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:32890639T>C	ENST00000330048.5	-	0	3159					NR_003083.2																						ACCAGCGGCTTGTAGTACACA	0.627000													3	125					0	0	0.184627	0	0
LRFN4	78999	broad.mit.edu	37	11	66625342	66625342	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:66625342C>T	ENST00000309602.4	+	1	370	c.127C>T	c.(127-129)Ccg>Tcg	p.P43S	PC_ENST00000393960.1_Intron|PC_ENST00000393958.2_Intron|LRFN4_ENST00000393952.3_Missense_Mutation_p.P43S|PC_ENST00000393955.2_Intron	NM_024036.4	NP_076941.2	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III domain containing 4	43	LRRNT.					integral to membrane				breast(1)|lung(1)|prostate(1)	3						GCTGTTTGTGCCGCCCAACGT	0.687000													5	276					0	0	0.184627	0	0
MPP6	51678	broad.mit.edu	37	7	24690147	24690147	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr7:24690147G>A	ENST00000396475.2	+	6	766	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	MPP6_ENST00000409761.1_Missense_Mutation_p.R44Q|MPP6_ENST00000222644.4_Missense_Mutation_p.R156Q	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	156	PDZ.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GTAATTGCCCGAATCCTCCAT	0.353000													7	400					0	0	0.278610	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103022865	103022865	+	Splice_Site	SNP	A	A	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:103022865A>T	ENST00000375735.2	+	21	3091	c.2946_splice	c.e21-1	p.I983_splice	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Splice_Site_p.I983_splice	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	983	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TAACCTTTAGATTTTGCCCTT	0.269000													11	107					0	0	0.457914	0	0
WDR36	134430	broad.mit.edu	37	5	110428198	110428198	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:110428198C>T	ENST00000506538.2	+	1	785	c.212C>T	c.(211-213)gCg>gTg	p.A71V	WDR36_ENST00000513710.2_Missense_Mutation_p.A71V|WDR36_ENST00000505303.1_Missense_Mutation_p.A15V	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	71					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GCGCTTTTTGCGGGGTTCCGG	0.612000													7	357					0	0	0.248553	0	0
DHTKD1	55526	broad.mit.edu	37	10	12142180	12142180	+	Missense_Mutation	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:12142180A>G	ENST00000263035.4	+	9	1737	c.1675A>G	c.(1675-1677)Aga>Gga	p.R559G		NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	559					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TTTACAGTCCAGAATGGAGAA	0.413000													259	802					0	0	0.870114	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098962	178098962	+	Missense_Mutation	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:178098962A>G	ENST00000397062.3	-	2	637	c.83T>C	c.(82-84)aTa>aCa	p.I28T	NFE2L2_ENST00000423513.1_Missense_Mutation_p.I12T|NFE2L2_ENST00000446151.2_Missense_Mutation_p.I12T|NFE2L2_ENST00000464747.1_Missense_Mutation_p.I12T|NFE2L2_ENST00000397063.4_Missense_Mutation_p.I12T	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	28					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.I28T(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCCAAGATCTATATCTTGCCT	0.358000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			62	207					0	0	0.870114	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	G	rs121913530		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:25398285C>G	ENST00000311936.3	-	2	225	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R	KRAS_ENST00000256078.4_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000556131.1_Missense_Mutation_p.G12R	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			19	138					0	0	0.624587	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549437	127549437	+	Missense_Mutation	SNP	G	G	A	rs147454300	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr9:127549437G>A	ENST00000373580.3	+	2	274	c.274G>A	c.(274-276)Gca>Aca	p.A92T		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	92										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CTCCTGTACCGCACCTCCCTC	0.617000													88	189					0	0	0.870114	0	0
CROCCP3	0	broad.mit.edu	37	1	16812982	16812982	+	RNA	SNP	A	A	C	rs139388756	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr1:16812982A>C	ENST00000263511.4	-	0	1329					NR_023386.1																						AGGTCCTTCTAGTGGAGCACC	0.667000													4	25					0	0	0.150653	0	0
KLHL40	131377	broad.mit.edu	37	3	42728164	42728164	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr3:42728164G>A	ENST00000287777.4	+	1	1154	c.1054G>A	c.(1054-1056)Gtc>Atc	p.V352I		NM_152393.2	NP_689606.2			kelch-like family member 40																		CAAGAACCACGTCAGCCTGGT	0.557000													84	225					0	0	0.870114	0	0
EBF3	253738	broad.mit.edu	37	10	131639152	131639152	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:131639152G>A	ENST00000368648.3	-	14	1562	c.1490C>T	c.(1489-1491)tCg>tTg	p.S497L	EBF3_ENST00000355311.5_Missense_Mutation_p.S506L	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	506	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AAATCCAGGCGAGCCAGGGAC	0.522000													162	519					0	0	0.870114	0	0
ANKRD26	22852	broad.mit.edu	37	10	27324226	27324226	+	Silent	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:27324226A>G	ENST00000376087.4	-	24	3318	c.3153T>C	c.(3151-3153)gaT>gaC	p.D1051D	ANKRD26_ENST00000436985.2_Silent_p.D1067D|ANKRD26_ENST00000376070.3_Silent_p.D608D	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1050						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GGTTAGACACATCAAAATTCA	0.343000													128	332					0	0	0.870114	0	0
CHRD	8646	broad.mit.edu	37	3	184104344	184104344	+	Missense_Mutation	SNP	T	T	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr3:184104344T>G	ENST00000204604.1	+	16	2243	c.1997T>G	c.(1996-1998)gTg>gGg	p.V666G	CHRD_ENST00000450923.1_Missense_Mutation_p.V666G|CHRD_ENST00000545352.1_Intron|CHRD_ENST00000348986.3_Missense_Mutation_p.V626G|EIF2B5_ENST00000444495.1_Intron	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	666					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCGAGGGGGTGCGGGCGCTG	0.726000													10	39					0	0	0.667858	0	0
BRF1	2972	broad.mit.edu	37	14	105707720	105707720	+	Missense_Mutation	SNP	G	G	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr14:105707720G>T	ENST00000546474.1	-	6	15535	c.576C>A	c.(574-576)caC>caA	p.H192Q	BRF1_ENST00000379937.2_Missense_Mutation_p.H165Q|BRF1_ENST00000446501.2_Intron|BRF1_ENST00000379932.4_5'UTR|BRF1_ENST00000440513.3_Missense_Mutation_p.H77Q|BRF1_ENST00000392557.4_5'UTR|BRF1_ENST00000551787.1_5'UTR|BRF1_ENST00000327359.3_Missense_Mutation_p.H77Q	NM_001242787.1|NM_001519.3	NP_001229716.1|NP_001510.2	Q92994	TF3B_HUMAN	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	192					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		ATTCCAGCAGGTGCGCAAAGC	0.632000													58	231					7.50695e-29	8.07814e-29	0.870114	1	0
PXDN	7837	broad.mit.edu	37	2	1668825	1668825	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:1668825G>A	ENST00000252804.4	-	11	1363	c.1313C>T	c.(1312-1314)aCg>aTg	p.T438M		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	438	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTCCTGAGGCGTCACAGTGAA	0.532000													22	69					0	0	0.608945	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212459533	212459533	+	Silent	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr1:212459533A>G	ENST00000261461.2	+	1	655	c.81A>G	c.(79-81)aaA>aaG	p.K27K		NM_006243.3	NP_006234.1	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B', alpha	27					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		TCACCCGGAAATCGGTCCGCA	0.701000													48	80					0	0	0.870114	0	0
SPTB	6710	broad.mit.edu	37	14	65266502	65266502	+	Missense_Mutation	SNP	C	C	T	rs149837193	byFrequency	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr14:65266502C>T	ENST00000389722.3	-	8	1080	c.1027G>A	c.(1027-1029)Gcc>Acc	p.A343T	SPTB_ENST00000389720.3_Missense_Mutation_p.A343T|SPTB_ENST00000542895.1_Missense_Mutation_p.A343T|SPTB_ENST00000389721.5_Missense_Mutation_p.A343T|SPTB_ENST00000556626.1_Missense_Mutation_p.A343T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	343					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTGCTGAAGGCCTGCAGCTGC	0.617000													105	299					0	0	0.870114	0	0
B3GAT1	27087	broad.mit.edu	37	11	134254062	134254062	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:134254062G>A	ENST00000524765.1	-	3	4677	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C	B3GAT1_ENST00000537389.1_Missense_Mutation_p.R58C|B3GAT1_ENST00000392580.1_Missense_Mutation_p.R45C|B3GAT1_ENST00000312527.4_Missense_Mutation_p.R45C|B3GAT1_ENST00000531510.1_5'UTR			Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	45					carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		GGCGTTTCGCGTCGGGGGTCA	0.711000													51	135					0	0	0.870114	0	0
SNAP25	6616	broad.mit.edu	37	20	10273541	10273541	+	Missense_Mutation	SNP	C	C	T	rs146976467		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr20:10273541C>T	ENST00000304886.2	+	5	383	c.175C>T	c.(175-177)Cgt>Tgt	p.R59C	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000254976.2_Intron	NM_003081.3	NP_003072.2	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	59	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome		p.R59C(1)		endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	ACAACTCGATCGTGTCGAAGA	0.403000													94	344					0	0	0.870114	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41101367	41101367	+	Silent	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:41101367C>T	ENST00000355341.4	+	2	831	c.330C>T	c.(328-330)ttC>ttT	p.F110F	ZFYVE19_ENST00000563530.1_3'UTR|ZFYVE19_ENST00000336455.5_Silent_p.F100F|ZFYVE19_ENST00000299173.10_Silent_p.F110F|ZFYVE19_ENST00000564258.1_5'UTR|ZFYVE19_ENST00000570108.1_Silent_p.F87F	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	110							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCCTAAGCTTCAGTGCAGCAG	0.562000													9	476					0	0	0.307466	0	0
MYEOV	26579	broad.mit.edu	37	11	69063185	69063185	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:69063185G>A	ENST00000535407.1	+	2	737	c.94G>A	c.(94-96)Gtg>Atg	p.V32M	MYEOV_ENST00000308946.3_Missense_Mutation_p.V90M|MYEOV_ENST00000441339.2_Missense_Mutation_p.V90M			Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	90										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GCGTGTTGCGGTGAGAGGAGC	0.632000													83	578					0	0	0.870114	0	0
TAF5	6877	broad.mit.edu	37	10	105128042	105128042	+	Missense_Mutation	SNP	C	C	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:105128042C>A	ENST00000369839.3	+	1	319	c.296C>A	c.(295-297)gCc>gAc	p.A99D	TAF5_ENST00000351396.4_Missense_Mutation_p.A99D	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	99	LisH.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTCTACTGGCCGTGCTGCAG	0.756000													3	52					6.4e-05	6.66947e-05	0.115264	1	0
GPT2	84706	broad.mit.edu	37	16	46956249	46956249	+	Missense_Mutation	SNP	C	C	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:46956249C>A	ENST00000440783.2	+	9	1498	c.833C>A	c.(832-834)cCa>cAa	p.P278Q	GPT2_ENST00000340124.4_Missense_Mutation_p.P378Q	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	378					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGTGCCCCCCAGTGTCTGGG	0.607000													160	491					3.12418e-63	3.47521e-63	0.870114	1	0
ARNT2	9915	broad.mit.edu	37	15	80800573	80800573	+	Silent	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:80800573G>A	ENST00000533983.1	+	7	1005	c.666G>A	c.(664-666)tcG>tcA	p.S222S	ARNT2_ENST00000303329.4_Silent_p.S233S|ARNT2_ENST00000527771.1_Silent_p.S222S			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	233					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			GCATGGGCTCGCGGCGGTCTT	0.537000													79	320					0	0	0.870114	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316442	40316442	+	Silent	SNP	T	T	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:40316442T>G	ENST00000593685.1	-	11	2271	c.1803A>C	c.(1801-1803)ccA>ccC	p.P601P	DYRK1B_ENST00000597639.1_Silent_p.P573P|DYRK1B_ENST00000430012.2_Silent_p.P561P|DYRK1B_ENST00000348817.3_Silent_p.P573P|DYRK1B_ENST00000323039.5_Silent_p.P601P			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	601					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GCGGGAGGGGTGGACGACCTC	0.716000													8	78					0	0	0.592651	0	0
SUZ12	23512	broad.mit.edu	37	17	30303572	30303572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:30303572C>T	ENST00000322652.5	+	8	1085	c.856C>T	c.(856-858)Cga>Tga	p.R286*	SUZ12_ENST00000580398.1_Nonsense_Mutation_p.R263*	NM_015355.2	NP_056170.2	Q15022	SUZ12_HUMAN	SUZ12 polycomb repressive complex 2 subunit	286					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding	p.R286*(1)	SSH2/SUZ12(2)|JAZF1/SUZ12(133)	breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(5)|skin(1)	21		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CAGAAGAAAACGAAATCGTGA	0.343000			T	JAZF1	endometrial stromal tumours								5	186					0	0	0.217242	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			67	156					0	0	0.870114	0	0
C2orf71	388939	broad.mit.edu	37	2	29295775	29295775	+	Silent	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:29295775C>T	ENST00000331664.5	-	1	1352	c.1353G>A	c.(1351-1353)ggG>ggA	p.G451G		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	451					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GGGTGCTTGTCCCCAGCTTCA	0.542000													127	389					0	0	0.870114	0	0
AACSP1	0	broad.mit.edu	37	5	178194331	178194331	+	RNA	SNP	C	C	T	rs112953089		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:178194331C>T	ENST00000503486.2	-	0	1306					NR_024035.1																						TGCCACTGAGCGTGTACTGCG	0.527000													23	70					0	0	0.624587	0	0
KRT39	390792	broad.mit.edu	37	17	39122914	39122914	+	Silent	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:39122914A>G	ENST00000355612.2	-	1	230	c.195T>C	c.(193-195)ttT>ttC	p.F65F	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	65	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GCTTGCGACAAAAGCGAGGAG	0.522000													214	753					0	0	0.870114	0	0
CACNA1C	775	broad.mit.edu	37	12	2702421	2702421	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:2702421G>A	ENST00000399655.1	+	19	2838	c.2573G>A	c.(2572-2574)cGc>cAc	p.R858H	CACNA1C_ENST00000402845.3_Missense_Mutation_p.R858H|CACNA1C_ENST00000399617.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399629.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399595.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399601.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399641.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000406454.3_Missense_Mutation_p.R858H|CACNA1C_ENST00000335762.5_Missense_Mutation_p.R883H|CACNA1C_ENST00000399591.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000480911.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399606.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000347598.4_Missense_Mutation_p.R858H|CACNA1C_ENST00000399637.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399644.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399649.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399597.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399621.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399634.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000344100.3_Missense_Mutation_p.R858H|CACNA1C_ENST00000399603.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000399638.1_Missense_Mutation_p.R858H|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R858H	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	858					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTCGGCCCTCGCCCACGACCA	0.512000													40	181					0	0	0.819951	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520323	33520323	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:33520323C>T	ENST00000297307.5	-	1	1089	c.1004G>A	c.(1003-1005)aGg>aAg	p.R335K		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	335						integral to membrane		p.R335K(4)									CTCCTCCACCCTCCCTGTCCT	0.557000													5	296					0	0	0.184627	0	0
HERC2P3	0	broad.mit.edu	37	15	20644850	20644850	+	RNA	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:20644850G>A	ENST00000428453.1	-	0	3097																		p.A803V(4)		central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CATGTCCCTCGCCCTTTCGGT	0.463000													6	457					0	0	0.217242	0	0
SLC35A2	7355	broad.mit.edu	37	X	48761886	48761886	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chrX:48761886G>A	ENST00000445167.2	-	4	729	c.710C>T	c.(709-711)tCt>tTt	p.S237F	SLC35A2_ENST00000413561.2_3'UTR|SLC35A2_ENST00000452555.2_3'UTR|SLC35A2_ENST00000247138.5_Intron|SLC35A2_ENST00000376521.1_3'UTR|SLC35A2_ENST00000376515.3_Missense_Mutation_p.S213F|SLC35A2_ENST00000376529.3_Intron	NM_001032289.1	NP_001027460.1	P78381	S35A2_HUMAN	solute carrier family 35 (UDP-galactose transporter), member A2	36					galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(2)	15						TGGGAGAAAAGACCATCTCCC	0.642000													27	19					0	0	0.706142	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376809.5_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			6	321					0	0	0.278610	0	0
MMP16	4325	broad.mit.edu	37	8	89086968	89086968	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr8:89086968G>A	ENST00000286614.6	-	7	1368	c.1087C>T	c.(1087-1089)Cag>Tag	p.Q363*	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	363	Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						CAAAACCACTGGTCCTGCAAA	0.498000													99	329					0	0	0.870114	0	0
FZD10	11211	broad.mit.edu	37	12	130647817	130647817	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:130647817C>T	ENST00000539839.1	+	1	814	c.232C>T	c.(232-234)Cga>Tga	p.R78*	FZD10_ENST00000229030.4_Silent_p.C110C	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GGGTCATGTGCGAGCAGGCCC	0.642000													31	584					0	0	0.740014	0	0
DYTN	391475	broad.mit.edu	37	2	207572064	207572064	+	Silent	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:207572064C>T	ENST00000452335.2	-	3	374	c.258G>A	c.(256-258)ccG>ccA	p.P86P		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	86						plasma membrane	zinc ion binding	p.P86P(2)		breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GAGTGAGTTCCGGAGCTCTGG	0.522000													13	64					0	0	0.435327	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702139	27702139	+	Silent	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:27702139G>A	ENST00000438700.3	-	1	1158	c.1041C>T	c.(1039-1041)ctC>ctT	p.L347L		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	347					spermatid development	integral to membrane	hedgehog receptor activity	p.L347L(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						TAAATTGATCGAGCAAATGGG	0.517000													346	1057					0	0	0.870114	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													9	150					0	0	0.335167	0	0
TERT	0	broad.mit.edu	37	5	1268676	1268676	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:1268676G>A	ENST00000296820.5	-	7	2416	c.2359C>T	c.(2359-2361)Cga>Tga	p.R787*	TERT_ENST00000334602.6_Silent_p.G847G|TERT_ENST00000310581.5_Silent_p.G847G|TERT_ENST00000508104.2_Nonsense_Mutation_p.R787*			O14746	TERT_HUMAN	telomerase reverse transcriptase	0	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCTCCATGTCGCCGTAGCACA	0.627000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				68	264					0	0	0.870114	0	0
IL31RA	133396	broad.mit.edu	37	5	55206448	55206448	+	Silent	SNP	C	C	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:55206448C>A	ENST00000396834.1	+	14	2029	c.1533C>A	c.(1531-1533)acC>acA	p.T511T	IL31RA_ENST00000359040.5_Silent_p.T530T|IL31RA_ENST00000490985.1_Silent_p.T388T|IL31RA_ENST00000447346.2_Silent_p.T530T|IL31RA_ENST00000354961.4_Silent_p.T511T	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	498	Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TGGCCAGCACCAGTGCTGGGG	0.473000													134	584					4.28411e-51	4.66074e-51	0.870114	1	0
PLCE1	51196	broad.mit.edu	37	10	96005755	96005755	+	Missense_Mutation	SNP	A	A	G			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:96005755A>G	ENST00000260766.3	+	8	3107	c.2473A>G	c.(2473-2475)Aaa>Gaa	p.K825E	PLCE1_ENST00000371375.1_Missense_Mutation_p.K517E|PLCE1_ENST00000371385.3_Missense_Mutation_p.K517E|PLCE1_ENST00000371380.2_Missense_Mutation_p.K825E	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	825					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TGAGCAATCCAAAGAATACGA	0.433000													110	295					0	0	0.870114	0	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1101_splice	c.e13-1	p.L368_splice	POLR3B_ENST00000539066.1_Splice_Site_p.L310_splice|POLR3B_ENST00000549195.1_3'UTR	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													8	42					0	0	0.411799	0	0
COL6A1	1291	broad.mit.edu	37	21	47422162	47422162	+	Silent	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr21:47422162C>T	ENST00000361866.3	+	32	2211	c.2097C>T	c.(2095-2097)ggC>ggT	p.G699G	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	699	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GGATGGCGGGCGGCACCTTCA	0.697000													21	54					0	0	0.592651	0	0
SHC4	399694	broad.mit.edu	37	15	49255053	49255053	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:49255053C>T	ENST00000332408.4	-	1	588	c.160G>A	c.(160-162)Ggc>Agc	p.G54S		NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	54	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TGCGGCGAGCCCTTGTTCCCG	0.662000													150	418					0	0	0.870114	0	0
HRC	3270	broad.mit.edu	37	19	49658442	49658442	+	Missense_Mutation	SNP	G	G	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:49658442G>T	ENST00000252825.4	-	1	239	c.53C>A	c.(52-54)gCc>gAc	p.A18D	HRC_ENST00000595625.1_Missense_Mutation_p.A18D	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	18					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GAGCAGGCTGGCCACCCCAGC	0.667000													107	313					4.22592e-57	4.64852e-57	0.870114	1	0
PLXDC2	84898	broad.mit.edu	37	10	20534299	20534299	+	Missense_Mutation	SNP	G	G	C			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr10:20534299G>C	ENST00000377252.3	+	13	2179	c.1338G>C	c.(1336-1338)gaG>gaC	p.E446D	PLXDC2_ENST00000377242.3_Missense_Mutation_p.E397D|PLXDC2_ENST00000377238.2_3'UTR	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	446						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						GTGCAGCTGAGAAGAAAGGGG	0.468000													84	329					0	0	0.870114	0	0
TAF2	6873	broad.mit.edu	37	8	120843973	120843973	+	Splice_Site	SNP	T	T	C			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr8:120843973T>C	ENST00000378164.2	-	2	382		c.e2-2			NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGATGGGTTGtatattaataa	0.244000													60	158					0	0	0.870114	0	0
MTMR4	9110	broad.mit.edu	37	17	56582201	56582201	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:56582201C>T	ENST00000323456.5	-	12	1362	c.1238G>A	c.(1237-1239)cGc>cAc	p.R413H	MTMR4_ENST00000579925.1_Missense_Mutation_p.R413H	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	413	Myotubularin phosphatase.|Substrate binding (By similarity).					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCGGTGTGCGGTCCCAGCC	0.532000													9	761					0	0	0.307466	0	0
COL6A5	256076	broad.mit.edu	37	3	130095344	130095344	+	Missense_Mutation	SNP	G	G	C			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr3:130095344G>C	ENST00000265379.6	+	3	826	c.332G>C	c.(331-333)gGa>gCa	p.G111A	COL6A5_ENST00000432398.2_Missense_Mutation_p.G111A			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	111	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CTGCAGATAGGAAAGGCTCTT	0.502000													15	42					0	0	0.457914	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													6	270					0	0	0.217242	0	0
RP11-86H7.1	0	broad.mit.edu	37	1	95215655	95215656	+	RNA	INS	-	-	AG			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr1:95215655_95215656insAG	ENST00000452922.1	-	0	326																											gaaagaaagaaagaaagaaaga	0.312													2	4	---	---	---	---					
GS1-204I12.1	0	broad.mit.edu	37	1	185588813	185588814	+	RNA	DEL	AC	AC	-	rs113755277		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr1:185588813_185588814delAC	ENST00000436955.1	-	0	424																											TATATTacagacacacacacac	0.381													2	4	---	---	---	---					
AC096559.1	0	broad.mit.edu	37	2	12607546	12607549	+	RNA	DEL	CTAT	CTAT	-	rs7568368		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:12607546_12607549delCTAT	ENST00000412294.1	+	0	412																											tccttccttcctatcttccttcct	0.471													8	5	---	---	---	---					
AC018730.1	0	broad.mit.edu	37	2	105440965	105440966	+	RNA	INS	-	-	TGG	rs150937258	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:105440965_105440966insTGG	ENST00000458253.1	-	0	147				AC018730.1_ENST00000454729.1_RNA|AC018730.1_ENST00000443988.1_RNA|AC018730.1_ENST00000447876.1_RNA|AC018730.1_ENST00000413121.1_RNA																							gatggtggtgatggtggtggtg	0.569													6	7	---	---	---	---					
AC018890.6	0	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	36	---	---	---	---					
HOXD-AS2	0	broad.mit.edu	37	2	177000879	177000882	+	RNA	DEL	ACAC	ACAC	-	rs72244756		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr2:177000879_177000882delACAC	ENST00000440016.2	-	0	393				HOXD-AS2_ENST00000426965.1_RNA																							AAAGAAAAGAacacacacacacac	0.500													3	3	---	---	---	---					
RP11-48F14.1	0	broad.mit.edu	37	3	186173679	186173680	+	RNA	DEL	AC	AC	-	rs72278665		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr3:186173679_186173680delAC	ENST00000427914.1	-	0	1763					NR_033844.1																						CACCCCAAAGacacacacacac	0.416													2	4	---	---	---	---					
ZNF876P	0	broad.mit.edu	37	4	212236	212236	+	RNA	DEL	A	A	-	rs80061878		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr4:212236delA	ENST00000356347.3	+	0	172					NR_027481.1																						ctaaaaatacaaaaaaaaaaa	0.493													3	5	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cfs	p.H479fs	FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													8	87	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128018839	128018840	+	RNA	INS	-	-	GT	rs4000742	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr4:128018839_128018840insGT	ENST00000504050.1	-	0	483																											AATGCGTGCACgtgtgtgtgtg	0.391													4	2	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:24492973delA	ENST00000264463.4	-	10	2084	c.1577delT	c.(1576-1578)tcfs	p.F526fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			7	1315	---	---	---	---					
NR2F1-AS1	0	broad.mit.edu	37	5	92791549	92791550	+	RNA	INS	-	-	CA	rs148016646	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:92791549_92791550insCA	ENST00000607797.1	-	0	1229				NR2F1-AS1_ENST00000606739.1_RNA|NR2F1-AS1_ENST00000607831.1_RNA|NR2F1-AS1_ENST00000510254.1_RNA|NR2F1-AS1_ENST00000606233.1_RNA	NR_015369.1																						acacacacacgcacacacacac	0.322													3	4	---	---	---	---					
UNC5A	90249	broad.mit.edu	37	5	176301302	176301304	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr5:176301302_176301304delCAC	ENST00000329542.4	+	8	1387_1389	c.1113_1115delCAC	c.(1111-1116)agc>ag	p.ST371del	UNC5A_ENST00000261961.3_In_Frame_Del_p.ST331del	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	371					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGACCTCAGCACCACCACCACC	0.645													7	823	---	---	---	---					
RP11-446F17.3	0	broad.mit.edu	37	6	46652103	46652104	+	RNA	DEL	TG	TG	-	rs71830540		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr6:46652103_46652104delTG	ENST00000434329.2	-	0	232				RP11-446F17.3_ENST00000571590.1_RNA|RP11-446F17.3_ENST00000422284.2_RNA																							agcacacatttgtgtgtgtgtg	0.381													4	4	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100281686	100281688	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr7:100281686_100281688delGCT	ENST00000275732.5	-	15	3032_3034	c.1823_1825delAGC	c.(1822-1827)ctc>c	p.QL608del		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	608	Gln-rich.|Poly-Gln.									central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AATGCCGTGAGCTGCTGCTGCTG	0.690													7	187	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123674369	123674370	+	RNA	INS	-	-	TCCT	rs142512049	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr7:123674369_123674370insTCCT	ENST00000484322.1	+	0	75																											ccctctttATCtccttccttcc	0.550													5	5	---	---	---	---					
RP11-587H10.2	0	broad.mit.edu	37	8	93644950	93644951	+	RNA	INS	-	-	TGTG	rs138735990	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr8:93644950_93644951insTGTG	ENST00000523284.1	-	0	272																											GGTAGGCTGCAtgtgtgtgtgt	0.366													4	3	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906348	35906350	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr9:35906348_35906350delCTG	ENST00000354323.2	+	1	160_162	c.64_66delCTG	c.(64-66)del	p.L28del		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	28						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TGTGGCGGTCctgctgctgctgc	0.670													8	209	---	---	---	---					
RP11-531H8.1	0	broad.mit.edu	37	11	15607493	15607494	+	RNA	INS	-	-	AC	rs141728428	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr11:15607493_15607494insAC	ENST00000527770.1	+	0	550				RP11-531H8.2_ENST00000533082.1_lincRNA																							tgagtATTCAAacacacacaca	0.366													4	2	---	---	---	---					
DCP1B	196513	broad.mit.edu	37	12	2064701	2064701	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:2064701delT	ENST00000280665.6	-	6	627	c.548delA	c.(547-549)agfs	p.K183fs	DCP1B_ENST00000541700.1_Intron|DCP1B_ENST00000540622.1_Frame_Shift_Del_p.K57fs|DCP1B_ENST00000397173.4_Frame_Shift_Del_p.K81fs	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	183					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			ACTGGTTATCTTTTTTGGCTC	0.378													9	1014	---	---	---	---					
RP11-654D12.2	0	broad.mit.edu	37	12	90305779	90305782	+	RNA	DEL	ATGT	ATGT	-	rs9308288	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr12:90305779_90305782delATGT	ENST00000547370.1	+	0	227																											AAGTAAgtgcatgtgtgtgtgtgt	0.387													3	3	---	---	---	---					
LINC00566	0	broad.mit.edu	37	13	24906734	24906735	+	RNA	INS	-	-	TGTG	rs141391870	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr13:24906734_24906735insTGTG	ENST00000561557.1	+	0	87																											attccataatatgtgtgtgtgt	0.396													3	3	---	---	---	---					
LINC00519	0	broad.mit.edu	37	14	51783551	51783552	+	RNA	DEL	CA	CA	-	rs72286703		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr14:51783551_51783552delCA	ENST00000557518.1	-	0	257																											ATTTGGGATGcacacacacaca	0.356													2	4	---	---	---	---					
SNORA11	0	broad.mit.edu	37	14	70270922	70270922	+	RNA	DEL	T	T	-	rs11429169		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr14:70270922delT	ENST00000408133.1	-	0	126																											ATGGATTCTCTTTTTTTTTTT	0.353													10	52	---	---	---	---					
CTD-2341M24.1	0	broad.mit.edu	37	14	86538163	86538164	+	RNA	INS	-	-	GAGAGAGAGAAA	rs140881841	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr14:86538163_86538164insGAGAGAGAGAAA	ENST00000553668.1	+	0	182																											aggaagaaagggagagagagaa	0.416													8	57	---	---	---	---					
RP11-253M7.1	0	broad.mit.edu	37	15	69701563	69701564	+	RNA	DEL	AC	AC	-	rs62007330		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:69701563_69701564delAC	ENST00000558617.1	-	0	878				RP11-253M7.1_ENST00000560539.1_RNA|RP11-253M7.1_ENST00000558107.1_RNA																							caactccccaacacacacacac	0.356													3	5	---	---	---	---					
RP11-255M2.2	0	broad.mit.edu	37	15	95641967	95641968	+	RNA	DEL	AC	AC	-	rs72171488		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr15:95641967_95641968delAC	ENST00000554787.1	-	0	266																											gcaaaactgtacacacacacac	0.307													2	4	---	---	---	---					
PRRT2	112476	broad.mit.edu	37	16	29825016	29825016	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:29825016delC	ENST00000300797.6	+	2	815	c.641delC	c.(640-642)gcfs	p.A214fs	AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000567659.1_Frame_Shift_Del_p.A214fs|PRRT2_ENST00000567551.1_3'UTR|PRRT2_ENST00000358758.7_Frame_Shift_Del_p.A214fs			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	214	Pro-rich.			A -> AP (in Ref. 3; CAD38881).	response to biotic stimulus	integral to membrane		p.R217fs*12(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						GCCAATGGGGCCCCCCCCCGA	0.652													9	143	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53404542	53404543	+	RNA	INS	-	-	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:53404542_53404543insA	ENST00000565421.1	-	0	410																											TCTCCTTTCTCAAACTTAACCT	0.327													16	189	---	---	---	---					
RP11-467L24.1	0	broad.mit.edu	37	16	64519146	64519147	+	RNA	DEL	AC	AC	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:64519146_64519147delAC	ENST00000564046.1	+	0	354																											GCGTGCATGGacacacacacac	0.396													2	4	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81183625	81183626	+	RNA	DEL	TT	TT	-	rs11296516		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr16:81183625_81183626delTT	ENST00000525539.1	-	0	4553				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TTGTTCACACtttttttttttt	0.465													8	10	---	---	---	---					
HCRT	3060	broad.mit.edu	37	17	40336501	40336503	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr17:40336501_40336503delGCA	ENST00000293330.1	-	2	151_153	c.65_67delTGC	c.(64-69)ccg>c	p.LP22del		NM_001524.1	NP_001515.1	O43612	OREX_HUMAN	hypocretin (orexin) neuropeptide precursor	22					neuropeptide signaling pathway	cell junction|extracellular region|rough endoplasmic reticulum|synaptic vesicle		p.L22delL(1)		breast(1)|central_nervous_system(1)	2		all_cancers(22;1.39e-06)|all_epithelial(22;9.98e-06)|Breast(137;0.000143)|Ovarian(249;0.0221)|Myeloproliferative disorder(1115;0.0255)|Colorectal(1115;0.069)		BRCA - Breast invasive adenocarcinoma(366;0.124)		AGCGCGGgcggcagcagcagcag	0.704													7	112	---	---	---	---					
RP11-408H20.2	0	broad.mit.edu	37	18	28696726	28696727	+	RNA	INS	-	-	AAGG	rs71175759		TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr18:28696726_28696727insAAGG	ENST00000581836.1	+	0	208																											aggaaggaaggaagaaagaaag	0.426													2	4	---	---	---	---					
WBP7	0	broad.mit.edu	37	19	36214865	36214866	+	Frame_Shift_Ins	INS	-	-	G	rs34014681	by1000genomes	TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:36214865_36214866insG	ENST00000420124.1	+	8	3291_3292	c.3291_3292insG	c.(3289-3294)ccggggfs	p.PG1097fs	WBP7_ENST00000222270.7_Frame_Shift_Ins_p.PG1097fs|KMT2B_ENST00000607650.1_RNA																							ACTCGGAGCCCGGGGGCCCCCC	0.574													13	374	---	---	---	---					
ZNF428	126299	broad.mit.edu	37	19	44111875	44111877	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:44111875_44111877delTCC	ENST00000300811.3	-	3	905_907	c.459_461delGGA	c.(457-462)gaa>ga	p.EE157del	SRRM5_ENST00000526798.1_Intron|SRRM5_ENST00000607544.1_Intron	NM_182498.3	NP_872304.2	Q96B54	ZN428_HUMAN	zinc finger protein 428	157	Glu-rich.					intracellular	zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	5		Prostate(69;0.0153)				ctcctcctcttcctcctcctcct	0.660													7	189	---	---	---	---					
SLC8A2	6543	broad.mit.edu	37	19	47935504	47935507	+	Frame_Shift_Del	DEL	GCGA	GCGA	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:47935504_47935507delGCGA	ENST00000236877.6	-	9	2701_2704	c.2306_2309delTCGC	c.(2305-2310)ccfs	p.LA769fs	SLC8A2_ENST00000542837.1_Frame_Shift_Del_p.LA525fs|SLC8A2_ENST00000539381.1_Frame_Shift_Del_p.LA232fs	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	769					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GAAGTGGGAGGCGAGGTCCCCAAT	0.623													97	337	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chr19:54675747_54675749delTCC	ENST00000376591.4	-	2	332_334	c.201_203delGGA	c.(199-204)gat>ga	p.ED67del	TMC4_ENST00000301187.4_In_Frame_Del_p.ED61del	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	67	Poly-Glu.					integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645													8	724	---	---	---	---					
RP11-545D19.1	0	broad.mit.edu	37	X	34332105	34332112	+	RNA	DEL	GTGTGTGT	GTGTGTGT	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chrX:34332105_34332112delGTGTGTGT	ENST00000412652.1	-	0	357																											TGACTGAGTGgtgtgtgtgtgtgtgtgt	0.385													3	4	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030561	47030563	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chrX:47030561_47030563delGGA	ENST00000377604.3	+	4	1078_1080	c.336_338delGGA	c.(334-339)ggg>gg	p.GE112del	RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000329236.7_Intron|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	112					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CCGAGCAAGGggaggaggaggag	0.660													7	97	---	---	---	---					
ZMYM3	9203	broad.mit.edu	37	X	70472554	70472555	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FZ-5924-01A-13D-1609-08	TCGA-FZ-5924-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d8a9adaa-884a-4fe3-addf-a9e689c276d0	00935704-940c-4cb0-a0f6-03682d465c6a	g.chrX:70472554_70472555insA	ENST00000373998.1	-	2	1248_1249	c.551_552insT	c.(550-552)ccafs	p.P184fs	ZMYM3_ENST00000373978.1_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000314425.5_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000373988.1_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000373984.3_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000373981.1_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000353904.2_Frame_Shift_Ins_p.P184fs|ZMYM3_ENST00000373982.1_Frame_Shift_Ins_p.P184fs	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	184					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TTGGGCTCTGTGGCTGCCCTTG	0.604													114	137	---	---	---	---