Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GMPPA	29926	broad.mit.edu	37	2	220371072	220371072	+	Missense_Mutation	SNP	G	G	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:220371072G>T	ENST00000358215.3	+	12	1459	c.1090G>T	c.(1090-1092)Gat>Tat	p.D364Y	GMPPA_ENST00000373917.3_Missense_Mutation_p.D417Y|GMPPA_ENST00000373908.1_Missense_Mutation_p.D364Y|AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000341142.3_Missense_Mutation_p.D364Y|GMPPA_ENST00000313597.5_Missense_Mutation_p.D364Y	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	364					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		TAACCCCAACGATCCCCGAGC	0.657000													89	376					6.71967e-41	7.2402e-41	1	1	0
COL12A1	1303	broad.mit.edu	37	6	75840656	75840656	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:75840656C>T	ENST00000322507.8	-	36	6288	c.5979G>A	c.(5977-5979)cgG>cgA	p.R1993R	COL12A1_ENST00000483888.2_Silent_p.R1993R|COL12A1_ENST00000416123.2_Silent_p.R1993R|COL12A1_ENST00000345356.6_Silent_p.R829R	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1993	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.R1993R(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCGGAATCAGCCGCTCCAGAT	0.537000													5	387					0	0	1	0	0
FAM111B	374393	broad.mit.edu	37	11	58892674	58892674	+	Silent	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:58892674G>A	ENST00000343597.3	+	4	1295	c.1104G>A	c.(1102-1104)ccG>ccA	p.P368P	FAM111B_ENST00000411426.1_Silent_p.P338P|FAM111B_ENST00000529618.1_Silent_p.P338P	NM_198947.3	NP_945185.1	Q6SJ93	F111B_HUMAN	family with sequence similarity 111, member B	368							catalytic activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(12)|ovary(3)|pancreas(1)|skin(1)	40						GACGGAGGCCGCATCTGGGTA	0.383000													8	746					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39462521	39462521	+	Missense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:39462521C>G	ENST00000261434.3	+	2	275	c.157C>G	c.(157-159)Ctt>Gtt	p.L53V	LIAS_ENST00000340169.2_Missense_Mutation_p.L53V|LIAS_ENST00000513731.1_Missense_Mutation_p.L53V|LIAS_ENST00000515061.1_3'UTR|LIAS_ENST00000381846.1_Missense_Mutation_p.L53V	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	53					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	ATCTGGTGATCTTGCAGACAG	0.403000													134	635					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52439312	52439312	+	Splice_Site	SNP	T	T	G	rs112194987		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:52439312T>G	ENST00000460680.1	-	11	1403		c.e11-2		BAP1_ENST00000296288.5_Splice_Site	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)						monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CTGCACCATCTGAGACAGGGC	0.587000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							157	515					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80943962	80943962	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:80943962C>T	ENST00000376588.3	+	9	1141	c.1073C>T	c.(1072-1074)gCc>gTc	p.A358V	PSAT1_ENST00000347159.2_Missense_Mutation_p.A312V	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	358					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	CAGAAGCTGGCCGCCTTCATG	0.418000													6	420					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44220861	44220861	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:44220861G>A	ENST00000371554.1	+	11	2025	c.1811G>A	c.(1810-1812)cGg>cAg	p.R604Q	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.R604Q|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.R604Q			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	604					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AATATGGAGCGGATCATGAAA	0.527000													11	690					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21065824	21065824	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:21065824G>A	ENST00000261383.3	-	28	3955	c.3956C>T	c.(3955-3957)gCg>gTg	p.A1319V	DNAH3_ENST00000415178.1_Missense_Mutation_p.A1319V	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1319	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GACAATCTGCGCAATCTGATC	0.542000													73	259					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													21	180					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47618421	47618421	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:47618421C>T	ENST00000383738.2	-	2	3193	c.1095G>A	c.(1093-1095)cgG>cgA	p.R365R	CSPG5_ENST00000456150.1_Silent_p.R227R|CSPG5_ENST00000264723.4_Silent_p.R365R	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	365					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AGCCGTTATGCCGCACAAAGC	0.627000													8	865					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													5	165					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64166850	64166850	+	Silent	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:64166850G>A	ENST00000395391.1	+	4	1543	c.168G>A	c.(166-168)ggG>ggA	p.G56G	ZNF107_ENST00000423627.1_Silent_p.G56G|ZNF107_ENST00000344930.3_Silent_p.G56G			Q9UII5	ZN107_HUMAN	zinc finger protein 107	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AGTGTACGGGGCACAAAGGAG	0.348000													5	354					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	897577	897577	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:897577G>A	ENST00000456758.2	+	19	2074	c.2074G>A	c.(2074-2076)Gat>Aat	p.D692N	SUN1_ENST00000452783.2_Missense_Mutation_p.D400N|SUN1_ENST00000401592.1_Missense_Mutation_p.D503N|SUN1_ENST00000389574.3_Missense_Mutation_p.D420N|SUN1_ENST00000413514.2_Missense_Mutation_p.D301N|SUN1_ENST00000405266.1_Missense_Mutation_p.D540N|SUN1_ENST00000425407.2_Missense_Mutation_p.D420N			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	530	SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding	p.D420N(1)		NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGAGACAGTGGATGCCGTACA	0.458000													168	788					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41277892	41277892	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:41277892G>A	ENST00000349496.5	+	12	2136	c.1856G>A	c.(1855-1857)tGt>tAt	p.C619Y	CTNNB1_ENST00000396185.3_Missense_Mutation_p.C619Y|CTNNB1_ENST00000405570.1_Missense_Mutation_p.C619Y|CTNNB1_ENST00000396183.3_Missense_Mutation_p.C619Y|CTNNB1_ENST00000453024.1_Missense_Mutation_p.C612Y	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	619					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.C619Y(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGGGTCCTCTGTGAACTTGCT	0.438000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				176	812					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432526	104432526	+	Missense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:104432526C>G	ENST00000361820.3	-	3	2768	c.2168G>C	c.(2167-2169)tGt>tCt	p.C723S		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	723					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GAGGGCATAACAGATGTTCAA	0.433000													6	610					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118140187	118140187	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chrX:118140187G>A	ENST00000365713.2	+	5	1559	c.1396G>A	c.(1396-1398)Ggt>Agt	p.G466S	LONRF3_ENST00000304778.7_Missense_Mutation_p.G466S|LONRF3_ENST00000371628.3_Missense_Mutation_p.G507S|LONRF3_ENST00000472173.1_3'UTR|LONRF3_ENST00000422289.2_Missense_Mutation_p.G251S			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	507					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						GTGCAAAGACGGTCTTTCACA	0.368000													267	499					0	0	1	0	0
PCDHB2	0	broad.mit.edu	37	5	140476009	140476009	+	Silent	SNP	C	C	T	rs147433427		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr5:140476009C>T	ENST00000194155.4	+	1	1783	c.1635C>T	c.(1633-1635)agC>agT	p.S545S		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		545	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTTGAGCAGCGAGGCGCTGG	0.706000													43	376					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													7	151					0	0	1	0	0
TGFBR1	7046	broad.mit.edu	37	9	101911535	101911535	+	Missense_Mutation	SNP	G	G	A	rs113605875		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:101911535G>A	ENST00000374994.4	+	9	1577	c.1460G>A	c.(1459-1461)cGg>cAg	p.R487Q	TGFBR1_ENST00000374990.2_Missense_Mutation_p.R410Q|TGFBR1_ENST00000552516.1_Missense_Mutation_p.R491Q|TGFBR1_ENST00000550253.1_Missense_Mutation_p.R418Q	NM_004612.2	NP_004603.1	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor 1	487	Protein kinase.		R -> P (in LDS1A and LDS2A).|R -> Q (in LDS2A and AAT5).|R -> W (in LDS2A).		activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	27		Acute lymphoblastic leukemia(62;0.0559)				ACAGCATTGCGGATTAAGAAA	0.373000													53	165					0	0	1	0	0
RP11-248G5.8	0	broad.mit.edu	37	13	52803480	52803480	+	RNA	SNP	G	G	T	rs142077571	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:52803480G>T	ENST00000451298.1	-	0	1024				RP11-64P12.8_ENST00000606031.1_RNA														p.F117L(1)									AATAAATAACGAATCTTTTTA	0.363000													4	66					2.56e-06	2.64649e-06	1	1	0
GPANK1	7918	broad.mit.edu	37	6	31631675	31631675	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:31631675C>T	ENST00000375906.1	-	3	1265	c.581G>A	c.(580-582)cGc>cAc	p.R194H	GPANK1_ENST00000375896.4_Missense_Mutation_p.R194H|GPANK1_ENST00000375895.2_Missense_Mutation_p.R194H|GPANK1_ENST00000375900.4_Missense_Mutation_p.R194H|GPANK1_ENST00000375893.2_Missense_Mutation_p.R194H	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	194						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						CCTGACCATGCGGGCTACCTC	0.607000													6	489					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89405142	89405142	+	RNA	SNP	C	C	T	rs3018757	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:89405142C>T	ENST00000532352.1	+	0	1082							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GTTCATGAAACTGTGAGGAGC	0.433000													7	674					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47246916	47246916	+	Silent	SNP	C	C	A	rs148956387	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:47246916C>A	ENST00000300404.2	+	11	1586	c.1527C>A	c.(1525-1527)ctC>ctA	p.L509L	B4GALNT2_ENST00000393354.2_Silent_p.L449L|B4GALNT2_ENST00000504681.1_Silent_p.L423L	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	509					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GGACCCTACTCGTGGGGTCAT	0.522000													96	472					1.54295e-31	1.62808e-31	1	1	0
MARCH5	54708	broad.mit.edu	37	10	94110927	94110927	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:94110927G>A	ENST00000358935.2	+	6	1132	c.800G>A	c.(799-801)cGc>cAc	p.R267H		NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	267					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						CAGGCACACCGCAAAATTCTG	0.353000													6	417					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261055	33261055	+	Silent	SNP	T	T	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:33261055T>G	ENST00000334528.9	-	4	2177	c.2178A>C	c.(2176-2178)ccA>ccC	p.P726P	FMN1_ENST00000561249.1_Silent_p.P851P|FMN1_ENST00000559047.1_Silent_p.P949P	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	949	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GTGCAAGTCCTGGGGGTGGTG	0.622000													14	183					0	0	1	0	0
AGPAT3	56894	broad.mit.edu	37	21	45402220	45402220	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr21:45402220G>A	ENST00000398063.2	+	9	1570	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K	AGPAT3_ENST00000546158.1_Missense_Mutation_p.E360K|AGPAT3_ENST00000398058.1_Missense_Mutation_p.E360K|AGPAT3_ENST00000398061.1_Missense_Mutation_p.E360K|AGPAT3_ENST00000327505.2_Missense_Mutation_p.E360K|AGPAT3_ENST00000291572.8_Missense_Mutation_p.E360K|AGPAT3_ENST00000479117.1_3'UTR	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	360				VTEIEKGSSYGNQEFKKKE -> ESLEPGRWRLQ (in Ref. 3; AAQ89067).	phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		AGGAGTAACTGAGATAGAAAA	0.453000													206	1003					0	0	1	0	0
GRM8	0	broad.mit.edu	37	7	126173847	126173847	+	Missense_Mutation	SNP	T	T	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:126173847T>G	ENST00000339582.2	-	9	2397	c.1589A>C	c.(1588-1590)aAa>aCa	p.K530T	GRM8_ENST00000480995.1_Intron|GRM8_ENST00000358373.3_Missense_Mutation_p.K530T|GRM8_ENST00000444921.2_Missense_Mutation_p.K530T			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	530					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGGGACCCCTTTCACCGTTTT	0.557000										HNSCC(24;0.065)			17	669					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88387407	88387407	+	Missense_Mutation	SNP	T	T	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:88387407T>G	ENST00000419482.2	+	3	426	c.341T>G	c.(340-342)gTg>gGg	p.V114G	SMYD1_ENST00000468008.1_3'UTR|SMYD1_ENST00000444564.2_Missense_Mutation_p.V114G|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.V114G(1)		NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						ATGTGGCGGGTGGAGAGAGAA	0.612000													13	91					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195410689	195410689	+	RNA	SNP	C	C	T	rs6583275	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:195410689C>T	ENST00000445430.1	+	0	1886																											CTTTGAGGTGCACTGGAGGAA	0.567000													10	109					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547141	132547141	+	Silent	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:132547141G>A	ENST00000333577.4	+	48	8446	c.8337G>A	c.(8335-8337)caG>caA	p.Q2779Q	EP400_ENST00000389562.2_Silent_p.Q2742Q|EP400_ENST00000389561.2_Silent_p.Q2743Q|EP400_ENST00000330386.6_Silent_p.Q2662Q|EP400_ENST00000332482.4_Silent_p.Q2706Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2779	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2742Q(2)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacagcagcagcagc	0.597000													5	328					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													6	156					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520323	33520323	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:33520323C>T	ENST00000297307.5	-	1	1089	c.1004G>A	c.(1003-1005)aGg>aAg	p.R335K		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	335						integral to membrane		p.R335K(4)									CTCCTCCACCCTCCCTGTCCT	0.557000													6	369					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79078379	79078379	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:79078379C>T	ENST00000321300.6	+	10	1225	c.1132C>T	c.(1132-1134)Cgg>Tgg	p.R378W	BAIAP2_ENST00000575245.1_Missense_Mutation_p.R411W|BAIAP2_ENST00000416299.2_Missense_Mutation_p.R241W|BAIAP2_ENST00000392411.3_Missense_Mutation_p.R300W|BAIAP2_ENST00000575712.1_Missense_Mutation_p.R378W|BAIAP2_ENST00000321280.7_Missense_Mutation_p.R378W|BAIAP2_ENST00000435091.3_Missense_Mutation_p.R378W|BAIAP2_ENST00000428708.2_Missense_Mutation_p.R378W	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	378	SH3.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			TGGCCGTATGCGGGTGAAGGC	0.642000													5	413					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168501	25168501	+	RNA	SNP	G	G	A	rs4770716	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:25168501G>A	ENST00000453498.1	+	0	1173																											TTTTCTCTTCGGTGAGTAATC	0.388000													5	192					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229567782	229567782	+	Missense_Mutation	SNP	C	C	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:229567782C>A	ENST00000366684.3	-	5	869	c.767G>T	c.(766-768)cGc>cTc	p.R256L	ACTA1_ENST00000366683.2_Missense_Mutation_p.R168L	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	256					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GCAGCGGAAGCGCTCGTTGCC	0.716000													4	119					1	1	1	1	0
LINC00969	0	broad.mit.edu	37	3	195410687	195410687	+	RNA	SNP	T	T	A	rs6583274	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:195410687T>A	ENST00000445430.1	+	0	1884																											CCCTTTGAGGTGCACTGGAGG	0.567000													9	112					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23728637	23728637	+	Missense_Mutation	SNP	G	G	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:23728637G>C	ENST00000546136.1	-	9	1263	c.1261C>G	c.(1261-1263)Cca>Gca	p.P421A	SOX5_ENST00000545921.1_Missense_Mutation_p.P424A|SOX5_ENST00000381381.2_Intron|SOX5_ENST00000451604.2_Missense_Mutation_p.P434A|SOX5_ENST00000396007.2_Missense_Mutation_p.P48A|SOX5_ENST00000541536.1_Intron|SOX5_ENST00000309359.1_Missense_Mutation_p.P421A|SOX5_ENST00000537393.1_Missense_Mutation_p.P399A			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	434					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AACGCTGCTGGGACAGAGGCT	0.483000													30	770					0	0	1	0	0
HYAL4	23553	broad.mit.edu	37	7	123508827	123508827	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:123508827C>G	ENST00000223026.4	+	3	1138	c.500C>G	c.(499-501)tCa>tGa	p.S167*	HYAL4_ENST00000476325.1_Nonsense_Mutation_p.S167*	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	167					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						AGACAGAAGTCAAGAAAGCTT	0.408000													113	496					0	0	1	0	0
IYD	389434	broad.mit.edu	37	6	150715311	150715311	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:150715311G>A	ENST00000344419.3	+	4	747	c.607G>A	c.(607-609)Gca>Aca	p.A203T	IYD_ENST00000392255.3_Missense_Mutation_p.A203T|IYD_ENST00000500320.3_Missense_Mutation_p.A203T|IYD_ENST00000425615.3_Missense_Mutation_p.A148T|IYD_ENST00000229447.5_Missense_Mutation_p.A203T|IYD_ENST00000392256.2_Missense_Mutation_p.A203T	NM_203395.2	NP_981932.1	Q6PHW0	IYD1_HUMAN	iodotyrosine deiodinase	203					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	15		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TGGTTTCGCCGCAAATGGCAA	0.433000													5	473					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5808002	5808002	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:5808002C>T	ENST00000380191.4	-	11	1595	c.1305G>A	c.(1303-1305)aaG>aaA	p.K435K	GDI2_ENST00000380132.4_Silent_p.K439K|GDI2_ENST00000380181.3_Silent_p.K390K|GDI2_ENST00000479928.1_5'UTR	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2	435					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						TCTTCTTGCGCTTCATTTCCT	0.348000													145	770					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77705082	77705082	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:77705082G>A	ENST00000328313.5	+	1	402	c.181G>A	c.(181-183)Ggg>Agg	p.G61R		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	61					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCCCGAGACGGGGTGAAGGC	0.647000													4	224					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104682725	104682725	+	Silent	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:104682725G>A	ENST00000526691.1	+	2	483	c.27G>A	c.(25-27)ctG>ctA	p.L9L	TXNRD1_ENST00000524698.1_5'UTR|TXNRD1_ENST00000529546.1_5'UTR|TXNRD1_ENST00000525566.1_Silent_p.L107L|TXNRD1_ENST00000429002.2_Silent_p.L107L|TXNRD1_ENST00000503506.2_5'UTR|TXNRD1_ENST00000378070.4_Silent_p.L56L|TXNRD1_ENST00000354940.6_Intron|TXNRD1_ENST00000542918.1_Silent_p.L7L|TXNRD1_ENST00000540716.1_5'UTR|TXNRD1_ENST00000388854.3_Silent_p.L9L|TXNRD1_ENST00000526390.1_5'UTR	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	107					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						GTCGGGCCCTGGAAGGAACGC	0.612000													121	633					0	0	1	0	0
SCFD2	152579	broad.mit.edu	37	4	54231749	54231749	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:54231749C>T	ENST00000401642.3	-	1	493	c.360G>A	c.(358-360)gcG>gcA	p.A120A	SCFD2_ENST00000388940.4_Silent_p.A120A	NM_152540.3	NP_689753.2	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	120	Poly-Ala.				protein transport|vesicle docking involved in exocytosis					breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	30			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CCGCTGCCGCCGCTGGGACAT	0.592000													72	251					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63170199	63170199	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:63170199C>T	ENST00000399298.3	-	6	1356	c.988G>A	c.(988-990)Gca>Aca	p.A330T	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	330						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					GAGGTCTGTGCCCGGCAACCA	0.597000													7	421					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1073261	1073261	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:1073261G>A	ENST00000313093.2	+	3	766	c.535G>A	c.(535-537)Gca>Aca	p.A179T	HMHA1_ENST00000536472.1_Missense_Mutation_p.A19T|HMHA1_ENST00000586866.1_Missense_Mutation_p.A183T|HMHA1_ENST00000539243.2_Missense_Mutation_p.A195T|HMHA1_ENST00000592335.1_3'UTR|HMHA1_ENST00000590214.1_Missense_Mutation_p.A206T|HMHA1_ENST00000543365.1_Missense_Mutation_p.A62T	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	179					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACGCTCACCGCAGCCGGCAC	0.637000													6	579					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													8	297					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155176731	155176731	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:155176731G>A	ENST00000357232.3	-	21	5515	c.5516C>T	c.(5515-5517)gCa>gTa	p.A1839V		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1839	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACCACTCAGTGCATCAATCTG	0.458000													46	197					0	0	1	0	0
RAB6B	51560	broad.mit.edu	37	3	133560230	133560230	+	Missense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:133560230C>G	ENST00000285208.4	-	4	537	c.188G>C	c.(187-189)cGa>cCa	p.R63P	RAB6B_ENST00000543906.1_Missense_Mutation_p.R63P|RAB6B_ENST00000486858.1_Missense_Mutation_p.R50P|RAB6B_ENST00000469959.1_Intron	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	63					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						GAGCTGCAGTCGCACCTGTCT	0.647000													69	353					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46952072	46952072	+	Missense_Mutation	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:46952072T>C	ENST00000409879.2	-	3	1077	c.17A>G	c.(16-18)tAc>tGc	p.Y6C	KIAA0226L_ENST00000378797.2_5'UTR|KIAA0226L_ENST00000378787.3_Intron|KIAA0226L_ENST00000429979.1_5'UTR|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.Y6C|KIAA0226L_ENST00000534925.1_Intron|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.Y6C|KIAA0226L_ENST00000480935.1_Intron|KIAA0226L_ENST00000389908.3_Intron|KIAA0226L_ENST00000378781.3_5'UTR			Q9H714	CM018_HUMAN	KIAA0226-like	0										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						GAGGAGAAAGTAATGATTGGA	0.438000													12	87					0	0	1	0	0
TMEM87A	25963	broad.mit.edu	37	15	42520944	42520944	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:42520944C>T	ENST00000389834.4	-	13	1470	c.1206G>A	c.(1204-1206)cgG>cgA	p.R402R	TMEM87A_ENST00000448392.1_Silent_p.R341R	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	402						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		TGGTGAAATGCCGATACAAAG	0.383000													6	519					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233351013	233351013	+	Silent	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:233351013G>A	ENST00000304546.1	-	2	561	c.351C>T	c.(349-351)gaC>gaT	p.D117D	ECEL1_ENST00000409941.1_Silent_p.D117D	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	117					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CGATGCTGGCGTCCAGGTTGG	0.726000													13	70					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													10	94					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109865648	109865648	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:109865648G>A	ENST00000256637.6	-	15	1988	c.1930C>T	c.(1930-1932)Cgg>Tgg	p.R644W	SORT1_ENST00000538502.1_Missense_Mutation_p.R507W	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	644	Interactions with LRPAP1 and NGFB.				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		TTGCGTAGCCGCAGAAACTGT	0.488000													5	426					0	0	1	0	0
CTC-457E21.3	0	broad.mit.edu	37	19	22780172	22780172	+	RNA	SNP	C	C	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:22780172C>A	ENST00000600260.1	+	0	250					NR_033899.1																						CCGAGACAACCACTTCTGGTG	0.507000													83	300					2.13431e-38	2.2677e-38	1	1	0
TNPO3	23534	broad.mit.edu	37	7	128658021	128658021	+	Missense_Mutation	SNP	A	A	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:128658021A>T	ENST00000393245.1	-	2	684	c.311T>A	c.(310-312)aTt>aAt	p.I104N	TNPO3_ENST00000265388.5_Missense_Mutation_p.I104N|TNPO3_ENST00000471166.1_Missense_Mutation_p.I104N|TNPO3_ENST00000471234.1_Missense_Mutation_p.I104N|TNPO3_ENST00000482320.1_Missense_Mutation_p.I38N	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	104					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						CTGCGTTACAATAACAGGTGA	0.408000													64	303					0	0	1	0	0
MPZL1	9019	broad.mit.edu	37	1	167734835	167734835	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:167734835C>T	ENST00000359523.2	+	2	309	c.107C>T	c.(106-108)tCa>tTa	p.S36L	MPZL1_ENST00000392121.3_Missense_Mutation_p.S36L|MPZL1_ENST00000474859.1_Missense_Mutation_p.S36L	NM_003953.5|NM_024569.4	NP_003944.1|NP_078845.3	O95297	MPZL1_HUMAN	myelin protein zero-like 1	36	Ig-like V-type.				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(2)	15	all_hematologic(923;0.215)					GCTGGAGTATCAGCCTTGGAA	0.433000													63	276					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7227181	7227181	+	Missense_Mutation	SNP	C	C	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:7227181C>A	ENST00000399464.2	-	12	2228	c.2213G>T	c.(2212-2214)cGc>cTc	p.R738L	NEURL4_ENST00000315614.7_Missense_Mutation_p.R738L|NEURL4_ENST00000570460.1_Missense_Mutation_p.R716L	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACAGTTGTGGCGGAGGGCGGT	0.622000											OREG0024134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	92	654					5.5301e-39	5.91682e-39	1	1	0
NFIC	4782	broad.mit.edu	37	19	3449068	3449068	+	Missense_Mutation	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:3449068T>C	ENST00000589123.1	+	7	1108	c.988T>C	c.(988-990)Tcc>Ccc	p.S330P	NFIC_ENST00000346156.5_Missense_Mutation_p.S306P|NFIC_ENST00000341919.3_Missense_Mutation_p.S339P|NFIC_ENST00000590282.1_Missense_Mutation_p.S339P|NFIC_ENST00000586919.1_Missense_Mutation_p.S306P|NFIC_ENST00000395111.3_Missense_Mutation_p.S330P|NFIC_ENST00000443272.2_Missense_Mutation_p.S339P	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	339					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CAACAGCCCGTCCCCCCAGGA	0.667000													11	252					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138169334	138169334	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:138169334C>T	ENST00000409968.1	+	14	3029	c.2851C>T	c.(2851-2853)Cgg>Tgg	p.R951W	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.R920W|THSD7B_ENST00000272643.3_Missense_Mutation_p.R951W					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCGAGGACTGCGGGTACAAGC	0.488000													7	666					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								17	331					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40662363	40662363	+	Missense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:40662363C>G	ENST00000267889.3	+	8	4137	c.4050C>G	c.(4048-4050)gaC>gaG	p.D1350E		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	1350					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CAGTGTATGACCCATCATTGC	0.637000													45	765					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29727462	29727462	+	Missense_Mutation	SNP	G	G	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:29727462G>C	ENST00000357586.2	-	19	2686	c.2500C>G	c.(2500-2502)Ctc>Gtc	p.L834V	AP1B1_ENST00000432560.2_Missense_Mutation_p.L827V|AP1B1_ENST00000356015.2_Missense_Mutation_p.L827V|AP1B1_ENST00000415447.1_Missense_Mutation_p.L827V|AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000317368.7_Missense_Mutation_p.L807V|AP1B1_ENST00000405198.1_Missense_Mutation_p.L834V|AP1B1_ENST00000402502.1_Missense_Mutation_p.L827V	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	834					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCACAAAGAGGATGTGCAGT	0.577000													215	1127					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10145836	10145836	+	Missense_Mutation	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:10145836T>C	ENST00000428126.2	-	7	766	c.497A>G	c.(496-498)cAt>cGt	p.H166R	CLEC1B_ENST00000298527.6_Missense_Mutation_p.H199R|CLEC1B_ENST00000348658.4_Missense_Mutation_p.H166R			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	199	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						TTTCCCATTATGAAAATAAGC	0.368000													137	671					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2159313	2159313	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:2159313C>T	ENST00000262304.4	-	15	6063	c.5855G>A	c.(5854-5856)gGc>gAc	p.G1952D	PKD1_ENST00000423118.1_Missense_Mutation_p.G1952D	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1952	PKD 15.		G -> D.		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTGGTTTTTGCCCCGCACGCT	0.711000													4	218					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245850589	245850589	+	Missense_Mutation	SNP	T	T	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:245850589T>A	ENST00000366518.4	+	9	3265	c.3161T>A	c.(3160-3162)aTg>aAg	p.M1054K	KIF26B_ENST00000407071.2_Missense_Mutation_p.M1435K			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1435					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGAAAGAGATGAAATTTGAG	0.552000													19	70					0	0	1	0	0
BAIAP2L2	80115	broad.mit.edu	37	22	38484914	38484914	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:38484914G>A	ENST00000381669.3	-	10	1103	c.959C>T	c.(958-960)cCg>cTg	p.P320L		NM_025045.4	NP_079321.3	Q6UXY1	BI2L2_HUMAN	BAI1-associated protein 2-like 2	320					filopodium assembly|signal transduction		cytoskeletal adaptor activity|SH3 domain binding			large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	8	Melanoma(58;0.045)					gccgccgcccgggcgcTCGCC	0.726000													3	63					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60892527	60892527	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:60892527G>A	ENST00000347785.3	+	9	1469	c.1303G>A	c.(1303-1305)Gca>Aca	p.A435T		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	435					cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CAACCACACGGCAACCGTCCG	0.567000													5	368					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168489	25168489	+	RNA	SNP	G	G	A	rs142860004	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:25168489G>A	ENST00000453498.1	+	0	1161																											TGAAAGTGCAGTTTTTCTCTT	0.363000													6	196					0	0	1	0	0
NDUFA4	4697	broad.mit.edu	37	7	10979660	10979660	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:10979660C>T	ENST00000339600.5	-	1	223	c.25G>A	c.(25-27)Gcc>Acc	p.A9T	NDUFA4_ENST00000492822.1_5'UTR	NM_002489.3	NP_002480.1	O00483	NDUA4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	9					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(2)|lung(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)	TGCTTCTTGGCCTGACCGATG	0.552000													89	1070					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161529826	161529826	+	Silent	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:161529826T>C	ENST00000392142.4	+	22	4319	c.4171T>C	c.(4171-4173)Ttg>Ctg	p.L1391L	MAP3K4_ENST00000366919.2_Silent_p.L1341L|MAP3K4_ENST00000366920.2_Silent_p.L1387L|MAP3K4_ENST00000348824.7_Silent_p.L1337L	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1391	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TGCAGACGAATTGAAAATATT	0.408000													167	579					0	0	1	0	0
HERC2P3	0	broad.mit.edu	37	15	20644850	20644850	+	RNA	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:20644850G>A	ENST00000428453.1	-	0	3097																		p.A803V(4)		central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CATGTCCCTCGCCCTTTCGGT	0.463000													5	195					0	0	1	0	0
DRD3	1814	broad.mit.edu	37	3	113890593	113890593	+	Missense_Mutation	SNP	T	T	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:113890593T>C	ENST00000383673.2	-	2	677	c.247A>G	c.(247-249)Atg>Gtg	p.M83V	DRD3_ENST00000467632.1_Missense_Mutation_p.M83V|DRD3_ENST00000295881.7_Missense_Mutation_p.M83V|DRD3_ENST00000460779.1_Missense_Mutation_p.M83V	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	83					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	ACCCAGGGCATCACCAAGGTG	0.557000													7	740					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88534045	88534045	+	Missense_Mutation	SNP	A	A	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:88534045A>T	ENST00000399271.1	+	4	827	c.707A>T	c.(706-708)gAt>gTt	p.D236V	DSPP_ENST00000282478.7_Missense_Mutation_p.D236V|RP11-742B18.1_ENST00000506480.1_RNA	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	236					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		ACTGGAGAAGATGCTGGCCTG	0.473000													56	222					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109625910	109625910	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:109625910C>T	ENST00000338432.7	+	13	2206	c.2087C>T	c.(2086-2088)gCg>gTg	p.A696V	ACACB_ENST00000377848.3_Missense_Mutation_p.A696V|ACACB_ENST00000377854.5_Missense_Mutation_p.A696V			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	696	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CACGAGTTTGCGGATTCCCAA	0.562000													6	696					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129847884	129847884	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:129847884G>A	ENST00000254667.3	+	6	653	c.374G>A	c.(373-375)cGt>cAt	p.R125H	PTPRE_ENST00000306042.5_Missense_Mutation_p.R67H|PTPRE_ENST00000471218.1_Silent_p.P123P|PTPRE_ENST00000430713.2_Missense_Mutation_p.R125H|PTPRE_ENST00000419012.2_Missense_Mutation_p.R125H	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	125					negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GAGGAGATCCGTATCAGATCC	0.587000													91	406					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			22	141					2.98393e-07	3.10572e-07	1	1	0
USP13	8975	broad.mit.edu	37	3	179472528	179472528	+	Missense_Mutation	SNP	A	A	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:179472528A>G	ENST00000263966.3	+	15	2278	c.1807A>G	c.(1807-1809)Att>Gtt	p.I603V	USP13_ENST00000482333.1_Intron|USP13_ENST00000496897.1_Missense_Mutation_p.I538V	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	603					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			AGATGTTTCTATTGATATGCC	0.443000													16	692					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789731	89789731	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:89789731C>T	ENST00000289816.5	+	4	707	c.395C>T	c.(394-396)gCg>gTg	p.A132V	ZNF276_ENST00000568064.1_Missense_Mutation_p.R126W|ZNF276_ENST00000446326.2_Missense_Mutation_p.R4W|ZNF276_ENST00000443381.2_Missense_Mutation_p.A207V	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	207	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CATGGACATGCGGCCAGCTGC	0.642000													78	379					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594614	64594614	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:64594614G>A	ENST00000342711.5	-	34	4296	c.4297C>T	c.(4297-4299)Cgc>Tgc	p.R1433C		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1433					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						AGCTTGGAGCGCACAAAAGGG	0.652000													7	805					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6067953	6067953	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:6067953C>T	ENST00000379959.3	-	2	273	c.100G>A	c.(100-102)Gcc>Acc	p.A34T	RP11-536K7.5_ENST00000440436.1_RNA|IL2RA_ENST00000379954.1_Missense_Mutation_p.A34T|IL2RA_ENST00000256876.6_Missense_Mutation_p.A34T	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	34	Sushi 1.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TTGAATGTGGCGTGTGGGATC	0.478000													70	339					0	0	1	0	0
RP11-248G5.8	0	broad.mit.edu	37	13	52803481	52803481	+	RNA	SNP	A	A	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:52803481A>C	ENST00000451298.1	-	0	1023				RP11-64P12.8_ENST00000606031.1_RNA																							ATAAATAACGAATCTTTTTAT	0.363000													4	65					0	0	1	0	0
BMP15	9210	broad.mit.edu	37	X	50659096	50659096	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chrX:50659096G>A	ENST00000252677.3	+	2	668	c.668G>A	c.(667-669)gGc>gAc	p.G223D		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	223					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					CTCTGGCATGGCACTTCATCC	0.448000													5	468					0	0	1	0	0
RP11-93K22.13	0	broad.mit.edu	37	3	129811972	129811972	+	RNA	SNP	G	G	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:129811972G>C	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							TTGACGGACAGAACCTTCCTT	0.408000													5	420					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22049265	22049265	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:22049265G>T	ENST00000406385.1	+	19	1432	c.1372G>T	c.(1372-1374)Gag>Tag	p.E458*	PPIL2_ENST00000335025.7_Nonsense_Mutation_p.E458*|PPIL2_ENST00000492445.2_Nonsense_Mutation_p.E458*|PPIL2_ENST00000412327.1_Nonsense_Mutation_p.E458*|PPIL2_ENST00000398831.3_Nonsense_Mutation_p.E458*|PPIL2_ENST00000456792.2_Intron			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	458					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					GGTAGCCCCGGAGACCAAAGT	0.642000													142	624					6.46734e-63	7.01776e-63	1	1	0
NUP153	9972	broad.mit.edu	37	6	17688753	17688753	+	Missense_Mutation	SNP	T	T	C	rs138192099		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:17688753T>C	ENST00000262077.2	-	2	207	c.208A>G	c.(208-210)Aca>Gca	p.T70A	NUP153_ENST00000537253.1_Missense_Mutation_p.T70A	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	70					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			CTTGTGTCTGTTGAACAGCTG	0.443000													41	721					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													5	330					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													6	372					8.12818e-05	8.29075e-05	1	1	0
U2AF2	11338	broad.mit.edu	37	19	56171880	56171880	+	Splice_Site	SNP	A	A	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:56171880A>C	ENST00000450554.2	+	4	1189		c.e4-1		U2AF2_ENST00000308924.4_Splice_Site	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding	p.?(2)		biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CACCTCCCCCAGTCGTTCCCC	0.637000													9	120					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142562188	142562188	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:142562188C>T	ENST00000392957.2	+	7	1417	c.630C>T	c.(628-630)taC>taT	p.Y210Y	EPHB6_ENST00000411471.2_Intron|EPHB6_ENST00000442129.1_Silent_p.Y210Y	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	210						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCGGCTTCTACGTGGCCTTCC	0.657000													27	1379					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122303575	122303575	+	Missense_Mutation	SNP	A	A	C			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:122303575A>C	ENST00000334010.7	-	3	923	c.502T>G	c.(502-504)Tgt>Ggt	p.C168G	CADPS2_ENST00000412584.2_Missense_Mutation_p.C168G|CADPS2_ENST00000313070.7_Missense_Mutation_p.C168G|CADPS2_ENST00000449022.2_Missense_Mutation_p.C168G	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	168					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding	p.C168G(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TTAGCAGAACACCCTCCACTC	0.373000													13	77					0	0	1	0	0
UGT1A3	0	broad.mit.edu	37	2	234637991	234637991	+	Missense_Mutation	SNP	C	C	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:234637991C>A	ENST00000482026.1	+	1	238	c.219C>A	c.(217-219)aaC>aaA	p.N73K	UGT1A9_ENST00000354728.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AAGAAGAGAACTTTTTCACCC	0.517000													8	644					5.18039e-06	5.31946e-06	1	1	0
KCNQ4	9132	broad.mit.edu	37	1	41284263	41284263	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:41284263C>T	ENST00000347132.5	+	4	701	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C	KCNQ4_ENST00000509682.2_Missense_Mutation_p.R207C	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	207					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GCGCAGCATGCGCTTCCTGCA	0.682000													5	199					0	0	1	0	0
LNX2	0	broad.mit.edu	37	13	28127529	28127529	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:28127529G>A	ENST00000316334.3	-	8	1723	c.1594C>T	c.(1594-1596)Cac>Tac	p.H532Y		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	532	PDZ 3.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GCCTCACTGTGACTTAAATTG	0.473000													83	410					0	0	1	0	0
DGUOK	1716	broad.mit.edu	37	2	74184338	74184338	+	Silent	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:74184338C>T	ENST00000264093.4	+	5	763	c.678C>T	c.(676-678)caC>caT	p.H226H	DGUOK-AS1_ENST00000453103.1_RNA|DGUOK_ENST00000462685.1_Intron|DGUOK_ENST00000348222.1_Intron|DGUOK_ENST00000356837.6_Silent_p.H204H	NM_080916.2	NP_550438.1	Q16854	DGUOK_HUMAN	deoxyguanosine kinase	226					guanosine metabolic process|purine base metabolic process|purine deoxyribonucleoside metabolic process|purine-containing compound salvage	mitochondrial matrix	ATP binding|deoxyguanosine kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	8						ATGGCCAACACGAAGCCTGGC	0.478000													38	187					0	0	1	0	0
RING1	6015	broad.mit.edu	37	6	33180151	33180151	+	Missense_Mutation	SNP	A	A	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr6:33180151A>G	ENST00000374656.4	+	7	1404	c.1196A>G	c.(1195-1197)tAt>tGt	p.Y399C	RING1_ENST00000478431.1_3'UTR	NM_002931.3	NP_002922.2	Q06587	RING1_HUMAN	ring finger protein 1	399	Necessary for interaction with CBX2 (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			endometrium(5)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|skin(4)	17						GAGCTGTGCTATGCTCCCACC	0.577000													10	34					0	0	1	0	0
FAM213A	84293	broad.mit.edu	37	10	82182230	82182230	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:82182230C>T	ENST00000372181.1	+	2	706	c.236C>T	c.(235-237)gCc>gTc	p.A79V	FAM213A_ENST00000372188.1_Missense_Mutation_p.A79V|FAM213A_ENST00000372187.5_Missense_Mutation_p.A79V|FAM213A_ENST00000372185.1_Missense_Mutation_p.A68V	NM_001243778.1|NM_001243782.1	NP_001230707.1|NP_001230711.1	Q9BRX8	CJ058_HUMAN	family with sequence similarity 213, member A	79						extracellular region											GTGATTATGGCCGTGCGGAGG	0.488000													5	349					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52384793	52384793	+	Missense_Mutation	SNP	G	G	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr8:52384793G>A	ENST00000356297.4	-	8	866	c.766C>T	c.(766-768)Cgg>Tgg	p.R256W	PXDNL_ENST00000543296.1_Missense_Mutation_p.R256W	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	256	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCTTCCGCCCGGCAGGTGAAG	0.443000													6	660					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150911268	150911268	+	Missense_Mutation	SNP	C	C	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr5:150911268C>T	ENST00000261800.5	-	13	9703	c.9691G>A	c.(9691-9693)Gcc>Acc	p.A3231T		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3231	Cadherin 29.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGGTGGGGCGTCCTCGGGC	0.677000													44	225					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790148	78790148	+	Missense_Mutation	SNP	G	G	A	rs68105355		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:78790148G>A	ENST00000376767.3	+	14	2515	c.2003G>A	c.(2002-2004)gGa>gAa	p.G668E	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						aaatggaatggaatgaaatgg	0.413000													4	114					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106165	27106165	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:27106165delG	ENST00000324856.7	+	20	6147	c.5776delG	c.(5776-5778)gafs	p.G1926fs	ARID1A_ENST00000540690.1_Frame_Shift_Del_p.G254fs|ARID1A_ENST00000457599.2_Frame_Shift_Del_p.G1709fs|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.G1543fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1926					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GACCGAGGATGGAGCTAAGAG	0.537			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								177	612	---	---	---	---					
ANKRD35	148741	broad.mit.edu	37	1	145562117	145562117	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:145562117delA	ENST00000355594.4	+	10	1892	c.1805delA	c.(1804-1806)gafs	p.E602fs		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	602										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTTGGAGGGGAAAAGGCCCTA	0.577													9	619	---	---	---	---					
MCL1	4170	broad.mit.edu	37	1	150551492	150551494	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:150551492_150551494delTCC	ENST00000369026.2	-	1	572_574	c.513_515delGGA	c.(511-516)gac>ga	p.ED171del	MCL1_ENST00000307940.3_In_Frame_Del_p.ED171del	NM_001197320.1|NM_021960.4	NP_001184249.1|NP_068779.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	171	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTACAACTCGTCCTCCTCCTCCT	0.635													9	643	---	---	---	---					
REN	5972	broad.mit.edu	37	1	204135375	204135377	+	In_Frame_Del	DEL	AGC	AGC	-	rs142739309		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr1:204135375_204135377delAGC	ENST00000367195.2	-	1	88_90	c.45_47delGCT	c.(43-48)ctc>ct	p.LL15del	REN_ENST00000272190.8_In_Frame_Del_p.LL15del			P00797	RENI_HUMAN	renin	15					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGAGCCCCAGAGCAGCAGCAGCA	0.581													7	750	---	---	---	---					
KIF3C	3797	broad.mit.edu	37	2	26203464	26203466	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:26203464_26203466delGTT	ENST00000264712.3	-	1	1900_1902	c.1321_1323delAAC	c.(1321-1323)del	p.N441del	KIF3C_ENST00000405914.1_In_Frame_Del_p.N441del	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	441	Poly-Asn.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGGGCGGTGGTTGTTGTTGTTG	0.621													7	1119	---	---	---	---					
AC007403.2	0	broad.mit.edu	37	2	67139780	67139781	+	RNA	DEL	AC	AC	-	rs72445228		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:67139780_67139781delAC	ENST00000426260.1	+	0	34																											AATGATCcatacacacacacac	0.411													2	4	---	---	---	---					
AC079896.1	0	broad.mit.edu	37	2	82230473	82230474	+	RNA	DEL	AC	AC	-	rs66478974		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:82230473_82230474delAC	ENST00000455845.1	-	0	139																											CCCAAAAACTacacacacacac	0.356													4	5	---	---	---	---					
MRPL35	51318	broad.mit.edu	37	2	86433365	86433366	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:86433365_86433366insA	ENST00000337109.4	+	2	214_215	c.180_181insA	c.(178-183)ctccacfs	p.H61fs	MRPL35_ENST00000605125.1_Frame_Shift_Ins_p.H61fs|MRPL35_ENST00000409180.1_Frame_Shift_Ins_p.H61fs|MRPL35_ENST00000254644.8_Frame_Shift_Ins_p.H61fs	NM_016622.3	NP_057706.2	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35	61					translation	mitochondrial ribosome	structural constituent of ribosome			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(2)	14						CTCCCAGACTTACCACATCTGA	0.406													169	905	---	---	---	---					
ANKRD36C	400986	broad.mit.edu	37	2	96525717	96525718	+	Frame_Shift_Ins	INS	-	-	T	rs77057279	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:96525717_96525718insT	ENST00000456556.1	-	61	3871_3872	c.3787_3788insA	c.(3787-3789)gaafs	p.E1263fs	ANKRD36C_ENST00000420871.2_Frame_Shift_Ins_p.E514fs|ANKRD36C_ENST00000419039.2_Frame_Shift_Ins_p.E290fs					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						CTTATTTTTCAGTTTTCGAATT	0.282													4	6	---	---	---	---					
RBM43	375287	broad.mit.edu	37	2	152112048	152112048	+	Splice_Site	DEL	T	T	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:152112048delT	ENST00000331426.5	-	2	364	c.214_splice	c.e2+1	p.K71_splice		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	71	RRM.						nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TGGAAATACCTTTTTTTTCTT	0.289													7	852	---	---	---	---					
SCN9A	6335	broad.mit.edu	37	2	167055992	167055992	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:167055992delT	ENST00000375387.4	-	27	5500	c.5160delA	c.(5158-5160)aafs	p.K1720fs	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Frame_Shift_Del_p.K1708fs|SCN9A_ENST00000303354.6_Frame_Shift_Del_p.K1720fs|SCN9A_ENST00000409435.1_Frame_Shift_Del_p.K1719fs			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1719						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGGATGAACTTTTTTTGGGT	0.423													7	1889	---	---	---	---					
PPIG	9360	broad.mit.edu	37	2	170493804	170493804	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr2:170493804delA	ENST00000260970.3	+	14	2256	c.2036delA	c.(2035-2037)gafs	p.E679fs	PPIG_ENST00000448752.2_Frame_Shift_Del_p.E679fs|PPIG_ENST00000409714.3_Frame_Shift_Del_p.E664fs	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	679					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AACAGCAGGGAAAAAAAGGCT	0.358													7	451	---	---	---	---					
ENTPD3-AS1	0	broad.mit.edu	37	3	40418568	40418568	+	RNA	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:40418568delA	ENST00000439293.1	-	0	143																											ggaaggaaggaaagggaaggg	0.547													8	29	---	---	---	---					
RP11-167H9.4	0	broad.mit.edu	37	3	149784483	149784485	+	RNA	DEL	GAG	GAG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:149784483_149784485delGAG	ENST00000487840.1	+	0	46																											ggaggaggaagaggaggaggagg	0.389													2	4	---	---	---	---					
TNIK	23043	broad.mit.edu	37	3	170783996	170783996	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr3:170783996delG	ENST00000436636.2	-	32	4323	c.3979delC	c.(3979-3981)tafs	p.L1327fs	TNIK_ENST00000538048.1_Frame_Shift_Del_p.L1279fs|TNIK_ENST00000470834.1_Frame_Shift_Del_p.L1290fs|TNIK_ENST00000488470.1_Frame_Shift_Del_p.L1272fs|TNIK_ENST00000475336.1_Frame_Shift_Del_p.L1235fs|TNIK_ENST00000341852.6_Frame_Shift_Del_p.L1243fs|TNIK_ENST00000369326.5_Frame_Shift_Del_p.L1305fs|TNIK_ENST00000357327.5_Frame_Shift_Del_p.L1298fs|TNIK_ENST00000284483.8_Frame_Shift_Del_p.L1319fs|TNIK_ENST00000460047.1_Frame_Shift_Del_p.L1264fs	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1327	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CTTTCACATAGAAACTTTAAC	0.393													67	434	---	---	---	---					
OTOP1	133060	broad.mit.edu	37	4	4204225	4204229	+	Frame_Shift_Del	DEL	TTGAG	TTGAG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:4204225_4204229delTTGAG	ENST00000296358.4	-	4	700_704	c.676_680delCTCAA	c.(676-681)tfs	p.LN226fs		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	226					biomineral tissue development	extracellular space|integral to membrane		p.L226fs*1(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTGTGCTCATTGAGTTGGTGCTTT	0.502													10	753	---	---	---	---					
RP11-83C7.2	0	broad.mit.edu	37	4	38510151	38510156	+	RNA	DEL	ACACAC	ACACAC	-	rs60752803		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:38510151_38510156delACACAC	ENST00000512517.1	-	0	78																											TCACCCCAAAacacacacacacacac	0.447													4	5	---	---	---	---					
BTC	685	broad.mit.edu	37	4	75681140	75681140	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:75681140delG	ENST00000395743.3	-	3	570	c.210delC	c.(208-210)ccfs	p.P70fs		NM_001729.2	NP_001720.1	P35070	BTC_HUMAN	betacellulin	70	EGF-like.				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(101;0.219)			TGTATTGCTTGGGGCACCTAG	0.473													7	1362	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													7	358	---	---	---	---					
RP11-219G10.3	0	broad.mit.edu	37	4	189418894	189418895	+	RNA	DEL	AC	AC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr4:189418894_189418895delAC	ENST00000510832.1	+	0	617																											CATCTGTTTTacacacacacac	0.376													4	6	---	---	---	---					
CTC-419K13.1	0	broad.mit.edu	37	5	73804846	73804847	+	RNA	INS	-	-	C	rs145980478	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr5:73804846_73804847insC	ENST00000507781.1	-	0	307																											actatgtgatacctgcaccacc	0.515													6	0	---	---	---	---					
PCDHA9	0	broad.mit.edu	37	5	140230590	140230590	+	Frame_Shift_Del	DEL	T	T	-	rs17844337		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr5:140230590delT	ENST00000378122.3	+	1	3234	c.2510delT	c.(2509-2511)atfs	p.I837fs	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCAGCAGATTTTTTTTCTG	0.279													11	1719	---	---	---	---					
HMGB3P22	0	broad.mit.edu	37	5	179121146	179121151	+	RNA	DEL	AAAAAA	AAAAAA	-	rs10553251		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr5:179121146_179121151delAAAAAA	ENST00000442010.2	+	0	253																											actccgtctcaaaaaaaaaaaaaaaa	0.485													7	61	---	---	---	---					
PPP1R17	10842	broad.mit.edu	37	7	31735179	31735179	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:31735179delA	ENST00000342032.3	+	3	807	c.179delA	c.(178-180)cafs	p.Q60fs	PPP1R17_ENST00000409146.3_Intron	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	60					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											GAGTCAGACCAAAAAAAACCA	0.438													7	869	---	---	---	---					
TRGC2	0	broad.mit.edu	37	7	38284884	38284885	+	RNA	INS	-	-	GG	rs138091320	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:38284884_38284885insGG	ENST00000436911.2	-	0	330																											TTATTTGTCAAGgtgtgtgtgt	0.391													40	716	---	---	---	---					
AC003991.3	0	broad.mit.edu	37	7	87904916	87904917	+	RNA	DEL	GT	GT	-	rs67533133	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:87904916_87904917delGT	ENST00000600908.1	+	0	93				AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000447758.1_RNA|AC003991.3_ENST00000594469.1_RNA																							CTCTCATGGGgtgtgtgtgtgt	0.406													3	5	---	---	---	---					
TRBV7-1	0	broad.mit.edu	37	7	142032162	142032163	+	RNA	DEL	GA	GA	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr7:142032162_142032163delGA	ENST00000547918.2	+	0	82																											atgtgtgtgtgAGAGAGAGAGA	0.505													7	64	---	---	---	---					
SFTPC	6440	broad.mit.edu	37	8	22020159	22020161	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr8:22020159_22020161delGTG	ENST00000521315.1	+	2	147_149	c.115_117delGTG	c.(115-117)del	p.V44del	SFTPC_ENST00000318561.3_In_Frame_Del_p.V44del|SFTPC_ENST00000522109.1_In_Frame_Del_p.V44del|SFTPC_ENST00000437090.2_In_Frame_Del_p.V44del|SFTPC_ENST00000520605.1_Intron|SFTPC_ENST00000524255.1_Intron			P11686	PSPC_HUMAN	surfactant protein C	44					respiratory gaseous exchange	extracellular space				autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCTTCTTATCGTGGTGGTGGTGG	0.601													8	892	---	---	---	---					
OSR2	116039	broad.mit.edu	37	8	99961401	99961402	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr8:99961401_99961402insG	ENST00000297565.4	+	2	717_718	c.221_222insG	c.(220-222)ggcfs	p.G74fs	OSR2_ENST00000435298.2_Frame_Shift_Ins_p.G74fs|OSR2_ENST00000523368.1_Frame_Shift_Ins_p.G74fs|OSR2_ENST00000457907.2_Frame_Shift_Ins_p.G195fs|OSR2_ENST00000522510.1_Frame_Shift_Ins_p.G74fs	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	74					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GAGATGGCGGCGGCGCAGGGCC	0.649													7	750	---	---	---	---					
CTD-2552K11.2	0	broad.mit.edu	37	8	124657755	124657756	+	RNA	INS	-	-	A	rs140124215	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr8:124657755_124657756insA	ENST00000524355.1	+	0	244																											aAAGAAGGGGGAAAGACAGAGA	0.485													10	6	---	---	---	---					
XPA	7507	broad.mit.edu	37	9	100455962	100455964	+	In_Frame_Del	DEL	TTC	TTC	-	rs3176652		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr9:100455962_100455964delTTC	ENST00000375128.4	-	2	314_316	c.250_252delGAA	c.(250-252)del	p.E84del		NM_000380.3	NP_000371.1	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	84	Interaction with CEP164 and required for UV resistance.|Poly-Glu.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity	p.E84*(1)		breast(1)|endometrium(4)|large_intestine(1)|lung(4)|prostate(1)	11		Acute lymphoblastic leukemia(62;0.158)				CAATTTTCTGTTCTTCTTCTTCT	0.340			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				8	531	---	---	---	---					
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	GCTCCTGCCATCCTGTCCCCA	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	ENST00000448048.2	-	1	233_253	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)gcg>gc	p.AGDRMAGA36del	AGAP4_ENST00000430779.2_5'UTR	NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	36					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.G37_A43delGDRMAGA(1)		central_nervous_system(1)|lung(1)|ovary(1)	3						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													9	41	---	---	---	---					
PRKG1-AS1	0	broad.mit.edu	37	10	54069065	54069066	+	RNA	INS	-	-	TA	rs71490737	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:54069065_54069066insTA	ENST00000420193.1	-	0	721																											AAAACAACCTCcacacacacac	0.391													3	3	---	---	---	---					
RP11-222A11.1	0	broad.mit.edu	37	10	67367559	67367559	+	RNA	DEL	T	T	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:67367559delT	ENST00000433152.3	+	0	594																											tctttctttctttttttcttt	0.393													6	12	---	---	---	---					
PRF1	5551	broad.mit.edu	37	10	72358622	72358624	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:72358622_72358624delCTT	ENST00000441259.1	-	3	1013_1015	c.853_855delAAG	c.(853-855)del	p.K285del	PRF1_ENST00000373209.2_In_Frame_Del_p.K285del	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	285	MACPF.		Missing (in FHL2).		apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						TCATCTTGTGCTTCTTCTTCTTC	0.591			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				9	647	---	---	---	---					
ZNF503-AS1	0	broad.mit.edu	37	10	77089193	77089196	+	RNA	DEL	CTTT	CTTT	-	rs71024539		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:77089193_77089196delCTTT	ENST00000416398.1	+	0	262				RP11-399K21.11_ENST00000418818.2_lincRNA	NR_038223.1																						tccttccttcctttctttctttct	0.397													9	21	---	---	---	---					
POLL	27343	broad.mit.edu	37	10	103345131	103345133	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:103345131_103345133delGGA	ENST00000370162.3	-	4	1007_1009	c.513_515delTCC	c.(511-516)ccc>cc	p.PP171del	POLL_ENST00000370172.1_In_Frame_Del_p.PP83del|POLL_ENST00000299206.4_In_Frame_Del_p.PP171del|DPCD_ENST00000470165.1_Intron|POLL_ENST00000456836.2_Intron|DPCD_ENST00000416979.2_Intron|POLL_ENST00000339310.3_Intron|POLL_ENST00000436284.2_Intron|POLL_ENST00000370158.3_Intron|POLL_ENST00000370169.1_In_Frame_Del_p.PP171del	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	171					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGGCCTGGTGGGAGGAGGAGGAG	0.591								DNA polymerases (catalytic subunits)					7	573	---	---	---	---					
NOLC1	9221	broad.mit.edu	37	10	103919000	103919002	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr10:103919000_103919002delAGC	ENST00000405356.1	+	6	893_895	c.658_660delAGC	c.(658-660)del	p.S227del	NOLC1_ENST00000605788.1_In_Frame_Del_p.S227del|NOLC1_ENST00000603742.1_5'UTR|NOLC1_ENST00000488254.2_In_Frame_Del_p.S228del			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	227	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		tagcagcagtagcagcagcagca	0.517													9	1324	---	---	---	---					
TSPAN4	0	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)del	p.L92del	TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													8	892	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:12316384_12316389delCTCCTA	ENST00000256186.2	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)cca>c	p.PPT469del		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	469	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding	p.T471delT(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.573													10	54	---	---	---	---					
FADS2	9415	broad.mit.edu	37	11	61607885	61607887	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:61607885_61607887delTCC	ENST00000278840.4	+	3	1028_1030	c.398_400delTCC	c.(397-402)ttc>t	p.FL133del	FADS2_ENST00000522056.1_In_Frame_Del_p.FL102del|FADS2_ENST00000521849.1_In_Frame_Del_p.FL133del|FADS2_ENST00000257261.6_In_Frame_Del_p.FL111del	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	133					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	CACGTGTTCTTCCTCCTCCTCCT	0.537													7	1326	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	RNA	INS	-	-	T	rs33924686	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr11:102738795_102738796insT	ENST00000532855.1	-	0	725_726							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N211fs*20(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													10	53	---	---	---	---					
EMG1	10436	broad.mit.edu	37	12	7080212	7080213	+	RNA	INS	-	-	C	rs36063533		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:7080212_7080213insC	ENST00000546220.1	+	0	157_158				U47924.28_ENST00000261406.6_lincRNA|U47924.19_ENST00000564245.1_RNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										GAGGCCGTAGTTTATTGTGGTG	0.569													7	92	---	---	---	---					
RP11-377D9.3	0	broad.mit.edu	37	12	13154583	13154583	+	RNA	DEL	G	G	-	rs75373880		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:13154583delG	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							TCTGCTGAGCGGGGGCCCCCG	0.731													6	9	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													8	1482	---	---	---	---					
TPT1-AS1	0	broad.mit.edu	37	13	45964344	45964344	+	RNA	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:45964344delA	ENST00000517509.1	+	0	1074				TPT1-AS1_ENST00000520585.1_RNA|TPT1-AS1_ENST00000519454.1_RNA|TPT1-AS1_ENST00000522673.1_RNA	NR_024458.1																						ATACTGAGCGAAAAACAATTT	0.358													8	33	---	---	---	---					
RP11-248G5.8	0	broad.mit.edu	37	13	52783345	52783348	+	RNA	DEL	TGTG	TGTG	-	rs34078394		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr13:52783345_52783348delTGTG	ENST00000451298.1	-	0	1229				RP11-64P12.8_ENST00000606031.1_RNA																							AAAATTACACtgtgtgtgtgtgtg	0.402													3	5	---	---	---	---					
RP11-363J20.1	0	broad.mit.edu	37	14	69655247	69655247	+	RNA	DEL	T	T	-	rs58288842		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr14:69655247delT	ENST00000554898.1	-	0	348																											TCTCTCTCTCttttttttttt	0.483													3	6	---	---	---	---					
ATG2B	55102	broad.mit.edu	37	14	96783571	96783572	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr14:96783571_96783572insT	ENST00000359933.4	-	20	4013_4014	c.3120_3121insA	c.(3118-3123)aatagafs	p.NR1040fs		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1040										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGAGAGTCTAATTTTTTTTTCC	0.371													7	477	---	---	---	---					
RP11-638I2.4	0	broad.mit.edu	37	14	100696020	100696021	+	RNA	DEL	GT	GT	-	rs5810982		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr14:100696020_100696021delGT	ENST00000554537.1	-	0	85																											CAgtgtgtgcgtgtgtgtgtgt	0.500													8	5	---	---	---	---					
ADAL	161823	broad.mit.edu	37	15	43641114	43641115	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:43641114_43641115insA	ENST00000422466.2	+	11	1217_1218	c.643_644insA	c.(643-645)aaafs	p.K215fs	ADAL_ENST00000389651.4_Frame_Shift_Ins_p.K215fs|ADAL_ENST00000428046.3_Frame_Shift_Ins_p.K188fs|ADAL_ENST00000562188.1_Frame_Shift_Ins_p.K215fs			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	215					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GATTCCAAACCAAAAAAAAGAA	0.455													7	476	---	---	---	---					
POLG	5428	broad.mit.edu	37	15	89876828	89876830	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:89876828_89876830delTGC	ENST00000268124.5	-	2	489_491	c.156_158delGCA	c.(154-159)caa>ca	p.QQ54del	POLG_ENST00000442287.2_In_Frame_Del_p.QQ54del	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	54	Poly-Gln.				base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			aggctgctgttgctgctgctgct	0.690								DNA polymerases (catalytic subunits)					7	130	---	---	---	---					
CTD-2536I1.1	0	broad.mit.edu	37	15	95835657	95835658	+	RNA	INS	-	-	AC	rs150479653	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr15:95835657_95835658insAC	ENST00000508732.2	-	0	271					NR_034095.1																						TATAATATTATacacacacaca	0.361													3	5	---	---	---	---					
CTD-2547E10.2	0	broad.mit.edu	37	16	21469994	21469994	+	RNA	DEL	A	A	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:21469994delA	ENST00000520823.2	-	0	749																											ACTGTACATTAAAAAAAAAAA	0.294													7	27	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089302	61089302	+	RNA	DEL	C	C	-	rs80101907		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:61089302delC	ENST00000591758.1	-	0	566																											GCttcttcttctttttttttt	0.244													7	194	---	---	---	---					
ELMO3	79767	broad.mit.edu	37	16	67237464	67237484	+	In_Frame_Del	DEL	TCATTGCCCCCTCCAAGCGGG	TCATTGCCCCCTCCAAGCGGG	-	rs148378199	by1000genomes	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr16:67237464_67237484delTCATTGCCCCCTCCAAGCGGG	ENST00000393997.2	+	19	2144_2164	c.2087_2107delTCATTGCCCCCTCCAAGCGGG	c.(2086-2109)tag>t	p.FIAPSKRE696del	ELMO3_ENST00000477898.1_In_Frame_Del_p.FIAPSKRE530del|ELMO3_ENST00000360833.1_In_Frame_Del_p.FIAPSKRE679del	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	643					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TACCTCAACTTCATTGCCCCCTCCAAGCGGGAGGTGAGTGT	0.629													28	436	---	---	---	---					
FXR2	9513	broad.mit.edu	37	17	7495872	7495874	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:7495872_7495874delCGG	ENST00000250113.7	-	15	2107_2109	c.1773_1775delCCG	c.(1771-1776)cgt>cg	p.RR591del	MPDU1_ENST00000423172.2_3'UTR	NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	591	Poly-Arg.		R -> P (in dbSNP:rs36013555).			cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		ACCACGGTTACGGCGGCGGCGGC	0.547													9	1888	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7801857	7801859	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:7801857_7801859delAAG	ENST00000380358.4	+	13	2273_2275	c.2272_2274delAAG	c.(2272-2274)del	p.K762del	CHD3_ENST00000358181.4_In_Frame_Del_p.K703del|CHD3_ENST00000330494.7_In_Frame_Del_p.K703del	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	703	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CCGCAAGTATAAGAAGAAGAAGA	0.488													7	483	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12647692	12647694	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr17:12647692_12647694delCAG	ENST00000425538.1	+	8	1110_1112	c.910_912delCAG	c.(910-912)del	p.Q310del	MYOCD_ENST00000395988.1_In_Frame_Del_p.Q214del|MYOCD_ENST00000343344.4_In_Frame_Del_p.Q310del	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	310	Gln-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AATCCTCAGCcagcagcagcagc	0.596													12	281	---	---	---	---					
FAM210A	125228	broad.mit.edu	37	18	13681751	13681751	+	Frame_Shift_Del	DEL	T	T	-	rs143162930		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr18:13681751delT	ENST00000322247.3	-	3	713	c.326delA	c.(325-327)agfs	p.K109fs	FAM210A_ENST00000402563.1_Frame_Shift_Del_p.K109fs|FAM210A_ENST00000588475.1_5'UTR	NM_001098801.1	NP_001092271.1	Q96ND0	CR019_HUMAN	family with sequence similarity 210, member A	109						integral to membrane		p.K109fs*29(1)									AGGCTCTTCCTTTTTTTCCGG	0.433													8	960	---	---	---	---					
CTC-512J12.4	0	broad.mit.edu	37	19	44917435	44917436	+	RNA	INS	-	-	TCCG			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:44917435_44917436insTCCG	ENST00000588655.1	-	0	488																											TTCtccttccttctttccttcc	0.416													7	42	---	---	---	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	CCT	-	rs62639328	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:46299165_46299167delCCT	ENST00000221538.3	-	6	2256_2258	c.2114_2116delAGG	c.(2113-2118)ggc>g	p.EG705del	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_In_Frame_Del_p.EG441del	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	705	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcgccctcctcctcctc	0.586													10	1108	---	---	---	---					
NAPSA	9476	broad.mit.edu	37	19	50868836	50868838	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:50868836_50868838delGCA	ENST00000253719.2	-	1	249_251	c.41_43delTGC	c.(40-45)cct>c	p.LP14del	NR1H2_ENST00000542413.1_Intron|NR1H2_ENST00000600978.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	14					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		TTcagcagaggcagcagcagcag	0.596													7	203	---	---	---	---					
LILRB2	0	broad.mit.edu	37	19	54780707	54780709	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:54780707_54780709delGAG	ENST00000391748.1	-	10	1559_1561	c.1432_1434delCTC	c.(1432-1434)del	p.L478del	LILRB2_ENST00000391749.4_In_Frame_Del_p.L479del|LILRB2_ENST00000434421.1_In_Frame_Del_p.L363del|LILRB2_ENST00000314446.5_In_Frame_Del_p.L478del|LILRB2_ENST00000391746.1_In_Frame_Del_p.L479del	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	479					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L479L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggaggagg	0.611													10	825	---	---	---	---					
RPL23AP79	0	broad.mit.edu	37	19	59091278	59091279	+	RNA	INS	-	-	TTCC	rs10674364		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr19:59091278_59091279insTTCC	ENST00000493504.1	+	0	129					NR_026052.1																						CTCTATTttctttccttccttc	0.446													8	20	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	G	-	rs138961929		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr20:4850569delG	ENST00000379333.1	-	12	1625	c.1233delC	c.(1231-1233)ccfs	p.P411fs	SLC23A2_ENST00000424750.2_Frame_Shift_Del_p.P297fs|SLC23A2_ENST00000468355.1_5'UTR|SLC23A2_ENST00000338244.1_Frame_Shift_Del_p.P411fs	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity	p.I412fs*4(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTGCGTGGATGGGGGGGGGTG	0.527													20	619	---	---	---	---					
ZHX3	23051	broad.mit.edu	37	20	39832962	39832962	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr20:39832962delT	ENST00000309060.3	-	4	1010	c.595delA	c.(595-597)ttfs	p.I199fs	ZHX3_ENST00000432768.2_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000544979.2_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000540170.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000557816.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000560361.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000559234.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000558993.1_Frame_Shift_Del_p.I199fs			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	199					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				AGTGTATGAATTTTTTTGGCT	0.488													8	847	---	---	---	---					
APP	351	broad.mit.edu	37	21	27394182	27394184	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr21:27394182_27394184delGTG	ENST00000358918.3	-	6	1036_1038	c.837_839delCAC	c.(835-840)aca>ac	p.TT279del	APP_ENST00000440126.3_In_Frame_Del_p.TT274del|APP_ENST00000474136.1_5'UTR|APP_ENST00000359726.3_In_Frame_Del_p.TT279del|APP_ENST00000357903.3_In_Frame_Del_p.TT279del|APP_ENST00000354192.3_In_Frame_Del_p.TT223del|APP_ENST00000439274.2_In_Frame_Del_p.TT223del|APP_ENST00000348990.5_In_Frame_Del_p.TT279del|APP_ENST00000448388.2_In_Frame_Del_p.TT244del|APP_ENST00000346798.3_In_Frame_Del_p.TT279del	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	279	Poly-Thr.				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				CACAGACTCTgtggtggtggtgg	0.522													7	333	---	---	---	---					
SLC5A3	6526	broad.mit.edu	37	21	35467569	35467569	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr21:35467569delT	ENST00000381151.3	+	2	584	c.72delT	c.(70-72)ggfs	p.G24fs	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	24		Implicated in sodium coupling (By similarity).				integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						TGTGCATTGGTTTTTTTGCCA	0.468													7	972	---	---	---	---					
TRAPPC10	7109	broad.mit.edu	37	21	45472274	45472275	+	Frame_Shift_Ins	INS	-	-	A	rs149217788	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr21:45472274_45472275insA	ENST00000291574.4	+	4	574_575	c.399_400insA	c.(397-402)aaaaaafs	p.KK133fs	TRAPPC10_ENST00000380221.3_Frame_Shift_Ins_p.KK133fs	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	133					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity	p.K133N(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						ATGATGCCAAGAAAAAAAACAA	0.356													9	706	---	---	---	---					
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661170	22661170	+	RNA	DEL	T	T	-	rs58170086		TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:22661170delT	ENST00000426066.1	+	0	262					NR_027293.1																						AGCATACAGGTTTTCCCCCCC	0.403													8	177	---	---	---	---					
TFIP11	24144	broad.mit.edu	37	22	26906183	26906185	+	In_Frame_Del	DEL	TCA	TCA	-	rs145794160	byFrequency	TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:26906183_26906185delTCA	ENST00000407690.1	-	4	337_339	c.54_56delTGA	c.(52-57)gac>ga	p.DD18del	TFIP11_ENST00000407431.1_In_Frame_Del_p.DD18del|TFIP11_ENST00000407148.1_In_Frame_Del_p.DD18del|TFIP11_ENST00000405938.1_In_Frame_Del_p.DD18del	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	18	Poly-Asp.				biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						CTCCCGCTCGTCATCATCATCAT	0.532													9	612	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610776	42610778	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chr22:42610776_42610778delTGC	ENST00000359486.3	-	1	670_672	c.534_536delGCA	c.(532-537)caa>ca	p.QQ178del	TCF20_ENST00000335626.4_In_Frame_Del_p.QQ178del	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	178	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CTGCTGGACTTGCTGCTGCTGCT	0.571													10	565	---	---	---	---					
PHF8	23133	broad.mit.edu	37	X	54011405	54011407	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chrX:54011405_54011407delCTC	ENST00000338154.6	-	18	2887_2889	c.2383_2385delGAG	c.(2383-2385)del	p.E795del	PHF8_ENST00000338946.6_In_Frame_Del_p.E694del|PHF8_ENST00000322659.8_In_Frame_Del_p.E778del|PHF8_ENST00000357988.5_In_Frame_Del_p.E831del	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	831	Ser-rich.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GACTGGCGTTCTCCTCCTCCTCC	0.591													9	524	---	---	---	---					
RNA5-8SP6	0	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-FZ-5922-01A-11D-1609-08	TCGA-FZ-5922-11A-01D-1609-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f015222f-24cd-4c16-8b94-af45b261e907	6207d556-6646-4a17-bb29-e80c8052e2af	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													7	91	---	---	---	---