Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KMT2C	58508	broad.mit.edu	37	7	151921114	151921114	+	Nonsense_Mutation	SNP	A	A	T	rs4024337		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:151921114A>T	ENST00000355193.2	-	20	3527	c.3309T>A	c.(3307-3309)tgT>tgA	p.C1103*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.C1103*					lysine (K)-specific methyltransferase 2C									p.C1103*(10)									CACATTGTCTACATTGCAGAA	0.338000													5	294					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324717	3324717	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:3324717T>C	ENST00000291231.1	+	1	856	c.856T>C	c.(856-858)Ttc>Ctc	p.F286L		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						GGTTGGGGTTTTCATGACTGT	0.512000													158	360					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81303936	81303936	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:81303936A>G	ENST00000258168.2	+	7	1477	c.1016A>G	c.(1015-1017)aAc>aGc	p.N339S	BCMO1_ENST00000425577.2_Missense_Mutation_p.N270S	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	339					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						TACCTGGCCAACCTGAACCAG	0.572000													5	258					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41790659	41790659	+	Silent	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:41790659T>G	ENST00000396930.3	-	18	5622	c.5079A>C	c.(5077-5079)ccA>ccC	p.P1693P	KAT6A_ENST00000265713.2_Silent_p.P1693P|KAT6A_ENST00000406337.1_Silent_p.P1693P	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1693	Gln/Pro-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										ggggagggggtgggggtggag	0.627000													9	76					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109371498	109371498	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:109371498G>A	ENST00000283195.6	+	16	2466	c.2340G>A	c.(2338-2340)ccG>ccA	p.P780P		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	780					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						ATTCTACACCGTCTCCTACCA	0.353000													6	928					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145311839	145311839	+	Missense_Mutation	SNP	A	A	T	rs58277049		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:145311839A>T	ENST00000369338.1	+	10	1278	c.1088A>T	c.(1087-1089)cAg>cTg	p.Q363L	NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_Intron|NBPF10_ENST00000342960.5_Intron			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	636										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAGGACTCACAGGATAGATGT	0.473000													7	383					0	0	1	0	0
PRR25	388199	broad.mit.edu	37	16	863394	863394	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:863394A>G	ENST00000301698.1	+	3	742	c.742A>G	c.(742-744)Acc>Gcc	p.T248A		NM_001013638.1	NP_001013660.1	Q96S07	PRR25_HUMAN	proline rich 25	248										large_intestine(1)|lung(1)|skin(1)	3						CCCTGGGTCCACCCCGACTCC	0.687000													7	60					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136569967	136569967	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:136569967C>T	ENST00000264162.2	-	7	2277	c.2267G>A	c.(2266-2268)gGc>gAc	p.G756D		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	756	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity	p.G756D(1)		breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TATGGGCATGCCATTCCCGGC	0.438000													5	354					0	0	1	0	0
IGHV1OR15-9	0	broad.mit.edu	37	15	20169960	20169960	+	RNA	SNP	G	G	A	rs150674714	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:20169960G>A	ENST00000338912.5	-	0	311																											CAGATCTCAGGCTGCTTAGCT	0.527000													7	748					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2092740	2092740	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:2092740G>C	ENST00000262113.4	+	37	4374	c.4233G>C	c.(4231-4233)gaG>gaC	p.E1411D	MYOM2_ENST00000523438.1_Missense_Mutation_p.E836D|MYOM2_ENST00000520298.1_3'UTR	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1411	Ig-like C2-type 5.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGACCTCCGAGGACTCGGGCA	0.547000													122	131					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													30	541					0	0	1	0	0
RP2	6102	broad.mit.edu	37	X	46719499	46719499	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:46719499G>C	ENST00000218340.3	+	3	1006	c.845G>C	c.(844-846)cGg>cCg	p.R282P		NM_006915.2	NP_008846.2	O75695	XRP2_HUMAN	retinitis pigmentosa 2 (X-linked recessive)	282			R -> W (might play a role in retinitis pigmentosa 2; reduces affinity for ARL3 3-fold; dbSNP:rs1805147).		cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding			NS(1)|large_intestine(4)|lung(5)|stomach(1)	11						AGGGTTTTTCGGGAAAAAGCA	0.378000													4	241					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													6	93					0	0	1	0	0
STOML3	0	broad.mit.edu	37	13	39550704	39550704	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr13:39550704T>C	ENST00000379631.4	-	3	546	c.202A>G	c.(202-204)Atc>Gtc	p.I68V	STOML3_ENST00000423210.1_Missense_Mutation_p.I59V	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	68						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TCAGCTTGGATGCGTCCCAGA	0.458000													12	175					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7044806	7044806	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:7044806G>A	ENST00000389658.3	-	7	984	c.891C>T	c.(889-891)tgC>tgT	p.C297C		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	297	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTCTCCCCGCAAGTATTAT	0.448000													7	719					0	0	1	0	0
TMEM106C	79022	broad.mit.edu	37	12	48359115	48359115	+	Missense_Mutation	SNP	C	C	T	rs146483924		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:48359115C>T	ENST00000429772.2	+	3	351	c.238C>T	c.(238-240)Cgc>Tgc	p.R80C	TMEM106C_ENST00000256686.6_Missense_Mutation_p.R80C|TMEM106C_ENST00000552561.1_Missense_Mutation_p.R80C|TMEM106C_ENST00000449758.2_Missense_Mutation_p.R80C|TMEM106C_ENST00000549288.1_Intron|TMEM106C_ENST00000552546.1_Intron|TMEM106C_ENST00000550552.1_Missense_Mutation_p.R80C	NM_001143842.1	NP_001137314.1	Q9BVX2	T106C_HUMAN	transmembrane protein 106C	80						endoplasmic reticulum membrane|integral to membrane		p.R80C(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TCAGAGATTGCGCCCTCAGCG	0.408000													5	555					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43318580	43318580	+	Silent	SNP	T	T	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:43318580T>A	ENST00000374518.4	+	20	3210	c.3147T>A	c.(3145-3147)tcT>tcA	p.S1049S		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1049					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGTTTAATTCTGCCTTGGAAG	0.403000													4	255					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19369427	19369427	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:19369427G>A	ENST00000379806.5	+	5	579	c.434G>A	c.(433-435)gGc>gAc	p.G145D	PDHA1_ENST00000422285.2_Missense_Mutation_p.G107D|PDHA1_ENST00000540249.1_Missense_Mutation_p.G107D|PDHA1_ENST00000545074.1_Missense_Mutation_p.G114D|PDHA1_ENST00000379805.3_Missense_Mutation_p.G107D	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	107					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	CTGGAGGCCGGCATCAACCCC	0.507000													6	966					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	69					0	0	1	0	0
DRD5	0	broad.mit.edu	37	4	9784028	9784028	+	Silent	SNP	T	T	C	rs2227841	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:9784028T>C	ENST00000304374.2	+	1	771	c.375T>C	c.(373-375)acT>acC	p.T125T		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	125					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGTGCTCCACTGCCTCCATCC	0.622000													8	194					0	0	1	0	0
SP2	6668	broad.mit.edu	37	17	46002859	46002859	+	Silent	SNP	A	A	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:46002859A>C	ENST00000376741.4	+	6	1830	c.1693A>C	c.(1693-1695)Agg>Cgg	p.R565R	AC003665.1_ENST00000451140.2_RNA|AC003665.1_ENST00000433001.1_RNA|AC003665.1_ENST00000411573.2_RNA|AC003665.1_ENST00000585280.1_RNA	NM_003110.5	NP_003101.3	Q02086	SP2_HUMAN	Sp2 transcription factor	565					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						CTGTGGGAAGAGGTTCACACG	0.612000													11	830					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110232234	110232234	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:110232234C>T	ENST00000418703.2	-	7	1485	c.1391G>A	c.(1390-1392)cGc>cAc	p.R464H	TRPV4_ENST00000541794.1_Missense_Mutation_p.R417H|TRPV4_ENST00000544971.1_Missense_Mutation_p.R357H|TRPV4_ENST00000261740.2_Missense_Mutation_p.R464H|TRPV4_ENST00000346520.2_Missense_Mutation_p.R404H|TRPV4_ENST00000392719.2_Missense_Mutation_p.R417H|TRPV4_ENST00000536838.1_Missense_Mutation_p.R430H|TRPV4_ENST00000537083.1_Missense_Mutation_p.R404H	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	464					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						CCCGAACTTGCGCCACTTGTC	0.602000													5	528					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73951097	73951097	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:73951097G>A	ENST00000358602.4	-	30	7144	c.7028C>T	c.(7027-7029)gCt>gTt	p.A2343V	ANKRD17_ENST00000330838.6_Missense_Mutation_p.A2092V|ANKRD17_ENST00000509867.2_Missense_Mutation_p.A2230V	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2343					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATGTTTGAAGCAAAGTTTCC	0.428000													6	670					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33123878	33123878	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:33123878T>G	ENST00000323959.4	-	10	810	c.671A>C	c.(670-672)gAg>gCg	p.E224A	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	224					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						CATTACTGTCTCATATTCCTA	0.423000													10	196					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													6	204					0	0	1	0	0
NECAB3	63941	broad.mit.edu	37	20	32246312	32246312	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:32246312C>G	ENST00000246190.6	-	10	1096	c.1041G>C	c.(1039-1041)gaG>gaC	p.E347D	NECAB3_ENST00000606525.1_5'UTR|NECAB3_ENST00000375238.4_Missense_Mutation_p.E313D	NM_031232.3	NP_112509.3	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	347	ABM.				antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			large_intestine(3)|lung(5)|skin(2)	10						CCTGCCAGAACTCATACAGGG	0.597000													27	1032					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	176					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57603830	57603830	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:57603830G>A	ENST00000243077.3	+	81	12924	c.12458G>A	c.(12457-12459)cGc>cAc	p.R4153H		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4153	EGF-like 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCATGTGACCGCAAGAAATGC	0.642000													5	422					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128470833	128470833	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:128470833G>A	ENST00000325888.8	+	1	403	c.142G>A	c.(142-144)Gag>Aag	p.E48K	FLNC_ENST00000346177.6_Missense_Mutation_p.E48K	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	48	Actin-binding.|CH 1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CTGGTGCAATGAGCACCTCAA	0.652000													52	104					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9453020	9453020	+	Missense_Mutation	SNP	T	T	C	rs151115651	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:9453020T>C	ENST00000393883.2	+	6	1541	c.893T>C	c.(892-894)gTt>gCt	p.V298A	ZNF177_ENST00000541595.2_Intron|ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000603380.1_Missense_Mutation_p.V298A|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000317221.7_3'UTR|ZNF559_ENST00000592896.1_3'UTR|ZNF177_ENST00000602738.1_Intron|ZNF559_ENST00000538743.1_Missense_Mutation_p.V218A|ZNF559_ENST00000587557.1_Missense_Mutation_p.V362A|ZNF559_ENST00000586255.1_Intron|ZNF177_ENST00000605471.1_Intron	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						AAACACTATGTTTGTAATGAA	0.358000													5	573					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628320	29628320	+	Nonsense_Mutation	SNP	G	G	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:29628320G>T	ENST00000278882.3	+	6	702	c.322G>T	c.(322-324)Gaa>Taa	p.E108*	FRG1B_ENST00000439954.2_Nonsense_Mutation_p.E113*|FRG1B_ENST00000358464.4_Nonsense_Mutation_p.E108*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGGAGAAGAAGAAATGATCAA	0.373000													9	236					1.33834e-09	1.38852e-09	1	1	0
SLC4A7	9497	broad.mit.edu	37	3	27444674	27444674	+	Silent	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:27444674A>G	ENST00000295736.5	-	15	2320	c.2250T>C	c.(2248-2250)taT>taC	p.Y750Y	SLC4A7_ENST00000435667.2_Silent_p.Y635Y|SLC4A7_ENST00000446700.1_Silent_p.Y742Y|SLC4A7_ENST00000445684.1_Silent_p.Y746Y|SLC4A7_ENST00000428386.1_Silent_p.Y626Y|SLC4A7_ENST00000440156.1_Silent_p.Y746Y|SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000388777.4_Silent_p.Y300Y|SLC4A7_ENST00000454389.1_Silent_p.Y759Y|SLC4A7_ENST00000455077.1_Silent_p.Y631Y|SLC4A7_ENST00000437179.1_Silent_p.Y631Y	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	750						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TATTAAATGCATATGTTTCTC	0.343000													55	516					0	0	1	0	0
TFG	10342	broad.mit.edu	37	3	100467317	100467317	+	Missense_Mutation	SNP	C	C	T	rs138185005		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:100467317C>T	ENST00000240851.4	+	8	1485	c.1145C>T	c.(1144-1146)gCg>gTg	p.A382V	TFG_ENST00000476228.1_Missense_Mutation_p.A378V|TFG_ENST00000490574.1_Missense_Mutation_p.A382V|TFG_ENST00000481203.1_3'UTR|TFG_ENST00000418917.2_Missense_Mutation_p.A378V	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	382					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						AATCCTTATGCGCGTAACCGT	0.517000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								5	404					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2852432	2852432	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:2852432C>T	ENST00000334241.4	+	4	507	c.369C>T	c.(367-369)gcC>gcT	p.A123A	ZNF555_ENST00000591539.1_Silent_p.A122A|AC006130.3_ENST00000589365.1_RNA	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGAGAAGCCCTCAGCCAGA	0.378000													4	273					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532454	50532454	+	Nonsense_Mutation	SNP	G	G	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:50532454G>T	ENST00000374144.3	+	3	2152	c.1864G>T	c.(1864-1866)Gag>Tag	p.E622*	C10orf71_ENST00000323868.4_Nonsense_Mutation_p.E622*			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	622										endometrium(1)	1						GGTGGAAGGAGAGTTGGAGAT	0.552000													40	40					1.52319e-26	1.62083e-26	1	1	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													6	384					0	0	1	0	0
XYLT2	64132	broad.mit.edu	37	17	48432344	48432344	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:48432344C>T	ENST00000017003.2	+	4	983	c.934C>T	c.(934-936)Cgg>Tgg	p.R312W	XYLT2_ENST00000507602.1_Missense_Mutation_p.R312W	NM_022167.2	NP_071450.2	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	312					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					GCGGAGCATGCGGGACCTGCT	0.632000													6	494					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40752940	40752940	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:40752940C>G	ENST00000381782.2	+	2	725	c.230C>G	c.(229-231)tCc>tGc	p.S77C	NSUN7_ENST00000316607.5_Missense_Mutation_p.S77C	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						CCCCTGCGGTCCTTGTCCGAG	0.468000													152	356					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													11	73					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144828704	144828704	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:144828704T>G	ENST00000338347.4	+	14	1750	c.1750T>G	c.(1750-1752)Tac>Gac	p.Y584D	NBPF9_ENST00000440491.2_3'UTR|NBPF9_ENST00000281815.8_Missense_Mutation_p.Y182D|NBPF9_ENST00000468645.1_3'UTR					neuroblastoma breakpoint family, member 9									p.L657L(3)|p.Y584D(1)		NS(2)|prostate(1)	3						CTTCGCCCTTTACGTGGACAA	0.438000													7	645					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243736307	243736307	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:243736307C>T	ENST00000366539.1	-	9	940	c.740G>A	c.(739-741)cGc>cAc	p.R247H	AKT3_ENST00000336199.5_Missense_Mutation_p.R247H|AKT3_ENST00000366540.1_Missense_Mutation_p.R247H|AKT3_ENST00000263826.5_Missense_Mutation_p.R247H			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	247	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAAACGTGTGCGGTCCTCAGA	0.418000													4	245					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													6	798					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72981280	72981280	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:72981280C>T	ENST00000262209.4	-	3	629	c.422G>A	c.(421-423)gGc>gAc	p.G141D		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	141						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	ATTATTCATGCCCTGCACAGC	0.517000													6	756					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28233300	28233300	+	Missense_Mutation	SNP	C	C	G	rs140950719		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:28233300C>G	ENST00000305242.5	-	12	1686	c.1594G>C	c.(1594-1596)Gtt>Ctt	p.V532L	ARMC4_ENST00000537576.1_Missense_Mutation_p.V224L|ARMC4_ENST00000545014.1_Missense_Mutation_p.V57L	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	532							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CCAAGGTCAACAATATTCTGT	0.378000													7	290					0	0	1	0	0
CBWD2	150472	broad.mit.edu	37	2	114212353	114212353	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:114212353A>C	ENST00000433343.2	+	7	730	c.418A>C	c.(418-420)Aaa>Caa	p.K140Q	CBWD2_ENST00000416503.2_Missense_Mutation_p.K176Q|CBWD2_ENST00000259199.4_Missense_Mutation_p.K176Q			Q8IUF1	CBWD2_HUMAN	COBW domain containing 2	176							ATP binding|protein binding			endometrium(1)|lung(1)	2						ATATGGATTAAAAGTAAGTTG	0.269000													4	223					0	0	1	0	0
CDK20	23552	broad.mit.edu	37	9	90585722	90585722	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:90585722T>G	ENST00000375883.3	-	4	775	c.469A>C	c.(469-471)Agc>Cgc	p.S157R	CDK20_ENST00000336654.5_Missense_Mutation_p.S170R|CDK20_ENST00000375871.4_Missense_Mutation_p.S157R|CDK20_ENST00000325303.8_Missense_Mutation_p.S157R|CDK20_ENST00000605159.1_Missense_Mutation_p.S157R	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	157	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TAGAGGCGGCTGCCGTCTGGG	0.597000													5	192					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													7	551					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107867515	107867515	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:107867515C>T	ENST00000370067.1	+	3	1485	c.858C>T	c.(856-858)taC>taT	p.Y286Y	NTNG1_ENST00000370070.2_Silent_p.Y286Y|NTNG1_ENST00000370074.4_Silent_p.Y286Y|NTNG1_ENST00000370072.3_Silent_p.Y286Y|NTNG1_ENST00000370073.2_Silent_p.Y286Y|NTNG1_ENST00000370071.2_Silent_p.Y286Y|NTNG1_ENST00000542803.1_Silent_p.Y286Y|NTNG1_ENST00000370061.3_Silent_p.Y286Y|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370065.1_Silent_p.Y286Y|NTNG1_ENST00000370066.1_Silent_p.Y286Y|NTNG1_ENST00000370068.1_Silent_p.Y286Y			Q9Y2I2	NTNG1_HUMAN	netrin G1	286	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding	p.Y286*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GCTACTTTTACGCGATCTCAG	0.458000													137	138					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93108681	93108681	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:93108681C>T	ENST00000359558.2	-	5	543	c.244G>A	c.(244-246)Gca>Aca	p.A82T	CALCR_ENST00000360249.4_Missense_Mutation_p.A64T|CALCR_ENST00000426151.1_Missense_Mutation_p.A64T|CALCR_ENST00000394441.1_Missense_Mutation_p.A64T|CALCR_ENST00000421592.1_Missense_Mutation_p.A64T	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	64					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CCTTGGTATGCGGGTAACTGC	0.373000													6	772					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154515294	154515294	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:154515294T>C	ENST00000368482.4	+	8	1338	c.500T>C	c.(499-501)aTg>aCg	p.M167T	TDRD10_ENST00000368480.3_Missense_Mutation_p.M167T|TDRD10_ENST00000479937.1_3'UTR	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	167							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCGTTGGAAATGAGGTGAGCA	0.512000													73	75					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93837734	93837734	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:93837734G>A	ENST00000315765.9	+	16	2731	c.2723G>A	c.(2722-2724)cGa>cAa	p.R908Q		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	908					copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATTACATGCCGAAAAGGAGTC	0.333000													4	146					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146059041	146059041	+	Silent	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:146059041A>G	ENST00000454497.2	-	21	2828	c.2691T>C	c.(2689-2691)caT>caC	p.H897H	OTUD4_ENST00000447906.2_Silent_p.H962H|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	961							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GAGTGGGAGGATGAGCCTTTC	0.478000													5	704					0	0	1	0	0
PAPL	0	broad.mit.edu	37	19	39590923	39590923	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:39590923C>T	ENST00000331256.5	+	5	836	c.562C>T	c.(562-564)Cgg>Tgg	p.R188W	PAPL_ENST00000594229.1_Intron	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		188						extracellular region	acid phosphatase activity|metal ion binding										TAGGTTCATGCGGCTCATTGA	0.627000													5	499					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839353	62839353	+	Silent	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:62839353A>G	ENST00000536311.1	+	7	1168	c.804A>G	c.(802-804)gaA>gaG	p.E268E	MYT1_ENST00000328439.1_Silent_p.E268E|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	268	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E268E(2)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaggaggaagaggaggagg	0.572000													4	84					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389323	1389323	+	Missense_Mutation	SNP	G	G	A	rs71299249	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:1389323G>A	ENST00000324803.4	+	1	3984	c.1024G>A	c.(1024-1026)Gcc>Acc	p.A342T		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	342					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGGAGTGCCCGCCTGCTCACA	0.667000													17	1381					0	0	1	0	0
MRPL14	64928	broad.mit.edu	37	6	44081762	44081762	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:44081762T>C	ENST00000372014.3	-	3	387	c.256A>G	c.(256-258)Att>Gtt	p.I86V		NM_032111.2	NP_115487.2	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14	86					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			TGCCCCACAATGAGCGCCTTT	0.562000													379	361					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	927043	927043	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:927043A>C	ENST00000407192.1	+	3	2711	c.194A>C	c.(193-195)aAc>aCc	p.N65T	GET4_ENST00000265857.3_Missense_Mutation_p.N118T			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	118					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						ATGGACCCCAACTCTCCTGAG	0.617000													6	517					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155252868	155252868	+	RNA	SNP	T	T	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:155252868T>A	ENST00000285718.7	+	0	819				WASH6P_ENST00000461007.1_RNA														p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000													19	52					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													14	297					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113115480	113115480	+	Missense_Mutation	SNP	G	G	A	rs145391746		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:113115480G>A	ENST00000393845.2	-	14	1730	c.1664C>T	c.(1663-1665)gCg>gTg	p.A555V	WDR52_ENST00000475568.1_5'UTR|WDR52_ENST00000295868.2_Missense_Mutation_p.A555V	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	555										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						CTTCCGTCCCGCAAAAATCGT	0.398000													5	287					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118525452	118525452	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:118525452G>A	ENST00000311085.8	+	29	7265	c.7185G>A	c.(7183-7185)ccG>ccA	p.P2395P	DMXL1_ENST00000539542.1_Silent_p.P2395P	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2395										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GTTTTAGGCCGTCAAAAATGT	0.408000													6	687					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651241	1651241	+	Silent	SNP	A	A	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:1651241A>C	ENST00000399676.2	+	1	209	c.171A>C	c.(169-171)ggA>ggC	p.G57G		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	57						keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		gctgtgggggatgtggctccg	0.682000													14	288					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366540	248366540	+	Silent	SNP	C	C	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:248366540C>A	ENST00000456743.1	+	1	209	c.171C>A	c.(169-171)acC>acA	p.T57T		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGCTCCACACCCCCATGTACC	0.542000													16	932					2.32078e-09	2.39286e-09	1	1	0
AHCYL2	23382	broad.mit.edu	37	7	129046281	129046281	+	Silent	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:129046281T>C	ENST00000325006.3	+	10	1323	c.1269T>C	c.(1267-1269)atT>atC	p.I423I	AHCYL2_ENST00000531335.2_Silent_p.I342I|AHCYL2_ENST00000490911.1_Silent_p.I320I|AHCYL2_ENST00000474594.1_Silent_p.I320I|AHCYL2_ENST00000446544.2_Silent_p.I422I|AHCYL2_ENST00000446212.1_Silent_p.I321I	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	423					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						TAACTGAAATTGACCCCATCT	0.517000													5	581					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223176649	223176649	+	Missense_Mutation	SNP	C	C	T	rs148231227	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:223176649C>T	ENST00000284476.6	+	8	2074	c.1910C>T	c.(1909-1911)gCg>gTg	p.A637V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	637	SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity	p.A637V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		GGGGTTTATGCGGGGACAGCT	0.448000													5	654					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10914388	10914388	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr21:10914388G>A	ENST00000298232.7	-	20	1644	c.1277C>T	c.(1276-1278)tCc>tTc	p.S426F	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.S406F|TPTE_ENST00000361285.4_Missense_Mutation_p.S444F	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	444	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAATAGTGGAAAAGACAAC	0.328000													9	160					0	0	1	0	0
LILRA2	0	broad.mit.edu	37	19	55086927	55086927	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:55086927C>G	ENST00000251377.3	+	6	993	c.860C>G	c.(859-861)cCc>cGc	p.P287R	LILRA2_ENST00000391737.1_Missense_Mutation_p.P275R|LILRA2_ENST00000391738.3_Missense_Mutation_p.P287R|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.P287R|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CCTGTGAGCCCCTCCCACGGG	0.637000													9	414					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112058796	112058796	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:112058796C>T	ENST00000371959.3	-	2	1181	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	AMOT_ENST00000524145.1_Silent_p.Q394Q|AMOT_ENST00000371958.1_Silent_p.Q162Q|AMOT_ENST00000371962.1_Silent_p.Q162Q|AMOT_ENST00000304758.1_5'UTR	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	394					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q394Q(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gctgctgctgctgttgttggt	0.582000													6	225					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7840299	7840299	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:7840299C>T	ENST00000420658.1	-	6	950	c.678G>A	c.(676-678)ccG>ccA	p.P226P	AFAP1_ENST00000382543.3_Silent_p.P226P|AFAP1_ENST00000358461.2_Silent_p.P226P|AFAP1_ENST00000360265.4_Silent_p.P226P	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	226	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CGAGAACAAGCGGGTCCGTGC	0.517000													8	509					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135346341	135346341	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:135346341T>C	ENST00000463117.2	+	7	1066	c.794T>C	c.(793-795)cTc>cCc	p.L265P	CYP2E1_ENST00000252945.3_Missense_Mutation_p.L265P|SPRN_ENST00000541506.1_Intron			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	265					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CCCCGGGACCTCACCGACTGC	0.517000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				4	234					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60036335	60036335	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:60036335C>T	ENST00000586569.1	+	9	1223	c.1185C>T	c.(1183-1185)agC>agT	p.S395S	TNFRSF11A_ENST00000269485.7_Intron	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	395					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				GGACACAGAGCACAGTGGGTT	0.532000													21	274					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23926745	23926745	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:23926745C>A	ENST00000402377.3	-	4	1748	c.1607G>T	c.(1606-1608)tGt>tTt	p.C536F	ZNF681_ENST00000395385.3_Missense_Mutation_p.C467F	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACATTCTTCACATGTGTAGGG	0.378000													88	244					1.27451e-61	1.36496e-61	1	1	0
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:9090831A>G	ENST00000397910.4	-	1	1187	c.984T>C	c.(982-984)ccT>ccC	p.P328P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	328	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCATGGAAAAAGGGATAGCTG	0.522000													4	352					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:49395482G>C	ENST00000419783.1	-	1	551	c.230C>G	c.(229-231)cCg>cGg	p.P77R	GPX1_ENST00000496791.1_5'UTR|GPX1_ENST00000419349.1_Missense_Mutation_p.P77R	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.726000													5	102					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129854107	129854107	+	Missense_Mutation	SNP	C	C	T	rs140507856	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:129854107C>T	ENST00000373425.3	-	4	1741	c.1124G>A	c.(1123-1125)cGc>cAc	p.R375H	ANGPTL2_ENST00000373417.1_Missense_Mutation_p.R73H|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373436.1_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	375	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						AAAGACTTTGCGGCCGGACCA	0.547000													9	1388					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59982897	59982897	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:59982897C>T	ENST00000265036.5	-	2	273	c.206G>A	c.(205-207)cGc>cAc	p.R69H	DEPDC1B_ENST00000545085.1_Missense_Mutation_p.R42H|DEPDC1B_ENST00000453022.2_Missense_Mutation_p.R69H	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	69	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				CGTTTGTTTGCGGGTCACTTC	0.473000													5	630					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													9	597					0	0	1	0	0
HTRA2	27429	broad.mit.edu	37	2	74759839	74759839	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:74759839C>T	ENST00000258080.3	+	7	1839	c.1209C>T	c.(1207-1209)caC>caT	p.H403H	LOXL3_ENST00000409249.1_3'UTR|HTRA2_ENST00000467961.1_3'UTR|HTRA2_ENST00000352222.3_Intron|LOXL3_ENST00000264094.3_3'UTR	NM_013247.4	NP_037379.1	O43464	HTRA2_HUMAN	HtrA serine peptidase 2	403	PDZ.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12						CCCCTGCACACCGGTGAGGGA	0.507000													11	214					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17648272	17648272	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:17648272T>G	ENST00000335393.4	+	6	746	c.608T>G	c.(607-609)cTc>cGc	p.L203R	FAM129C_ENST00000449408.2_5'UTR|FAM129C_ENST00000352727.3_Missense_Mutation_p.L203R|FAM129C_ENST00000300971.2_Missense_Mutation_p.L203R|FAM129C_ENST00000597887.1_3'UTR|FAM129C_ENST00000332386.5_Missense_Mutation_p.L203R|FAM129C_ENST00000595684.1_Missense_Mutation_p.L203R|FAM129C_ENST00000601861.1_Missense_Mutation_p.L172R|FAM129C_ENST00000599124.1_Missense_Mutation_p.L172R|FAM129C_ENST00000599164.1_Missense_Mutation_p.L172R|FAM129C_ENST00000600871.1_Missense_Mutation_p.L149R	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	203										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						CGCCGGCACCTCTGCTTCTCT	0.617000													222	399					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S152S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								6	171					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2666233	2666233	+	Splice_Site	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:2666233T>C	ENST00000320876.6	+	2	600		c.e2+2		SMCHD1_ENST00000261598.8_Splice_Site	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1						chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						ATAATTTTGGTAGGTAAACAG	0.264000													35	66					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1687905	1687905	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:1687905C>G	ENST00000252804.4	-	5	485	c.435G>C	c.(433-435)caG>caC	p.Q145H		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	145					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AAGTTTCTATCTGATTAAAGT	0.393000													11	14					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													4	86					0	0	1	0	0
RAET1G	353091	broad.mit.edu	37	6	150240238	150240238	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:150240238G>A	ENST00000367360.2	-	3	639	c.572C>T	c.(571-573)aCa>aTa	p.T191I	RP11-244K5.1_ENST00000605899.1_RNA|RP11-244K5.1_ENST00000446954.1_RNA|RAET1G_ENST00000479265.1_Missense_Mutation_p.T191I|RP11-244K5.8_ENST00000606915.1_RNA	NM_001001788.2	NP_001001788.2	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G	191	MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|urinary_tract(1)	13		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		AAGCCATCCTGTGCAGTCTCC	0.483000													8	483					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137476420	137476420	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:137476420G>A	ENST00000254900.5	-	26	3960	c.3589C>T	c.(3589-3591)Cgg>Tgg	p.R1197W		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1197					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACTTCTTGCCGCATCTCCACA	0.453000													6	886					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63667482	63667482	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:63667482G>A	ENST00000402010.2	+	8	1247	c.668G>A	c.(667-669)gGc>gAc	p.G223D	MARK2_ENST00000377809.4_Missense_Mutation_p.G223D|MARK2_ENST00000361128.5_Missense_Mutation_p.G223D|MARK2_ENST00000377810.3_Missense_Mutation_p.G190D|MARK2_ENST00000425897.2_Missense_Mutation_p.G190D|MARK2_ENST00000350490.7_Missense_Mutation_p.G223D|MARK2_ENST00000513765.2_Missense_Mutation_p.G190D|MARK2_ENST00000509502.2_Missense_Mutation_p.G190D|MARK2_ENST00000408948.3_Missense_Mutation_p.G190D|MARK2_ENST00000508192.1_Missense_Mutation_p.G223D|MARK2_ENST00000315032.8_Missense_Mutation_p.G223D|MARK2_ENST00000502399.3_Missense_Mutation_p.G223D|MARK2_ENST00000413835.2_Missense_Mutation_p.G223D	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	223	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CTCTTCCAGGGCAAAAAATAT	0.502000													6	665					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	103988220	103988220	+	Missense_Mutation	SNP	G	G	A	rs146698695		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:103988220G>A	ENST00000388887.2	+	3	467	c.263G>A	c.(262-264)cGc>cAc	p.R88H		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	88					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCCGGATGCCGCCATATTTGT	0.502000													8	762					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169562853	169562853	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:169562853G>A	ENST00000263686.6	-	14	2434	c.2397C>T	c.(2395-2397)ttC>ttT	p.F799F	SELP_ENST00000367794.2_Silent_p.F737F|SELP_ENST00000367793.2_Silent_p.F737F|SELP_ENST00000458599.2_Silent_p.F615F|SELP_ENST00000367792.2_Silent_p.F615F|SELP_ENST00000367791.2_Silent_p.F613F|SELP_ENST00000367786.2_Silent_p.F737F|SELP_ENST00000367788.2_Silent_p.F737F	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	799					platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CTTTTTGTCTGAAACGCTTTC	0.423000													14	158					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:3649787T>C	ENST00000382622.3	+	2	481	c.91T>C	c.(91-93)Tcc>Ccc	p.S31P	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.S22P	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	31					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652000													28	271					0	0	1	0	0
PAK2	5062	broad.mit.edu	37	3	196529917	196529917	+	Silent	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:196529917A>G	ENST00000327134.3	+	4	640	c.318A>G	c.(316-318)ctA>ctG	p.L106L		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	106	Autoregulatory region (By similarity).|GTPase-binding (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		CTCGATTACTACAGACCTCCA	0.378000													5	187					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058168	11058168	+	RNA	SNP	A	A	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr21:11058168A>T	ENST00000470054.1	-	0	479									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACATCTTTCAGGAGCTTGGT	0.388000													7	439					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296403	145296403	+	Silent	SNP	C	C	T	rs4996269	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:145296403C>T	ENST00000342960.5	+	3	360	c.325C>T	c.(325-327)Cta>Tta	p.L109L	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	109										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGACCCAGCTAAGGGAGAA	0.517000													10	860					0	0	1	0	0
SLC6A8	6535	broad.mit.edu	37	X	152959611	152959611	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:152959611C>T	ENST00000253122.5	+	9	1757	c.1281C>T	c.(1279-1281)acC>acT	p.T427T	SLC6A8_ENST00000430077.2_Silent_p.T312T|SLC6A8_ENST00000485324.1_3'UTR	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	427					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GCTTCATCACCGGCCTCCTCG	0.632000													51	630					0	0	1	0	0
EBPL	84650	broad.mit.edu	37	13	50235160	50235160	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr13:50235160G>C	ENST00000242827.6	-	4	615	c.565C>G	c.(565-567)Cta>Gta	p.L189V	EBPL_ENST00000378272.5_3'UTR|EBPL_ENST00000495963.2_5'UTR|EBPL_ENST00000378284.2_3'UTR|EBPL_ENST00000378270.5_3'UTR	NM_032565.3	NP_115954.1	Q9BY08	EBPL_HUMAN	emopamil binding protein-like	189					sterol metabolic process	endoplasmic reticulum membrane|integral to membrane	cholestenol delta-isomerase activity	p.L189V(9)		endometrium(8)|kidney(6)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Lung NSC(96;0.000468)|Breast(56;0.0011)|Prostate(109;0.00243)|Hepatocellular(98;0.0556)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.06e-09)		TTGAGTTCTAGCCATGACTGC	0.418000													4	174					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:146059006G>A	ENST00000454497.2	-	21	2863	c.2726C>T	c.(2725-2727)aCt>aTt	p.T909I	OTUD4_ENST00000447906.2_Missense_Mutation_p.T974I|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	973							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463000													7	764					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220480840	220480840	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:220480840C>T	ENST00000456909.1	+	25	3282	c.3192C>T	c.(3190-3192)atC>atT	p.I1064I	STK11IP_ENST00000295641.10_Silent_p.I1075I			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	1075					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGCCTGGATCCGGGAACCAT	0.627000													4	136					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11022906	11022906	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:11022906C>T	ENST00000327064.4	+	5	795	c.605C>T	c.(604-606)gCc>gTc	p.A202V	CARM1_ENST00000344150.4_Missense_Mutation_p.A202V	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	202					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding	p.A202V(2)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						TCGTTTTTTGCCGCCCAAGCT	0.622000													8	1377					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414391	179414391	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:179414391G>A	ENST00000589042.1	-	338	92282	c.92058C>T	c.(92056-92058)aaC>aaT	p.N30686N	TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.N21621N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Silent_p.N29045N|TTN_ENST00000359218.5_Silent_p.N21746N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Silent_p.N21813N|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Silent_p.N28118N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29045	Ig-like 138.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCATTGCCGTTTATTAGTT	0.413000													6	348					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11543659	11543659	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:11543659G>A	ENST00000262442.3	+	10	1927	c.1859G>A	c.(1858-1860)cGc>cAc	p.R620H	DNAH9_ENST00000454412.2_Missense_Mutation_p.R620H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	620	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGAGGCAGCGCATCCAGGGT	0.582000													7	737					0	0	1	0	0
ARL4C	10123	broad.mit.edu	37	2	235404735	235404735	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:235404735C>G	ENST00000390645.2	-	1	962	c.496G>C	c.(496-498)Gag>Cag	p.E166Q	ARL4C_ENST00000339728.3_Missense_Mutation_p.E166Q	NM_005737.3	NP_005728.2	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	166					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			endometrium(1)|ovary(1)|skin(1)|urinary_tract(1)	4		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		GTGAGGCCCTCGCCGATGATG	0.617000													95	106					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128528422	128528422	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:128528422C>T	ENST00000322313.4	-	2	292	c.134G>A	c.(133-135)gGa>gAa	p.G45E	WDR33_ENST00000409658.3_Missense_Mutation_p.G45E|WDR33_ENST00000393006.1_Missense_Mutation_p.G45E	NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	45					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CATTCGTTTTCCATCAAAAGT	0.418000													83	151					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135390519	135390519	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:135390519G>A	ENST00000442011.2	+	10	1540	c.1379G>A	c.(1378-1380)gGc>gAc	p.G460D	TGFBI_ENST00000305126.8_Missense_Mutation_p.G460D	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	460	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding	p.G460D(1)		breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACTCTGGGCGGCAAAAAACTG	0.423000													9	1048					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871076	170871076	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:170871076G>A	ENST00000392092.2	+	3	531	c.252G>A	c.(250-252)caG>caA	p.Q84Q	TBP_ENST00000540980.1_Silent_p.Q64Q|TBP_ENST00000230354.6_Silent_p.Q84Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	84	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q84Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.602000													7	89					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37853831	37853831	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:37853831G>A	ENST00000591471.1	+	9	1956	c.315G>A	c.(313-315)gcG>gcA	p.A105A	HKR1_ENST00000589392.1_Silent_p.A360A|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000324411.4_Silent_p.A378A|HKR1_ENST00000392153.3_Silent_p.A359A|HKR1_ENST00000541583.2_Silent_p.A317A|HKR1_ENST00000544914.1_Silent_p.A105A			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	378					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACCAGAGGGCGCACACTGGGG	0.532000													6	510					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54074910	54074910	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:54074910C>T	ENST00000253144.9	+	6	1395	c.62C>T	c.(61-63)gCc>gTc	p.A21V	ZNF331_ENST00000513265.1_Missense_Mutation_p.A21V|ZNF331_ENST00000513999.1_Missense_Mutation_p.A21V|ZNF331_ENST00000449416.1_Missense_Mutation_p.A21V|ZNF331_ENST00000511154.1_Missense_Mutation_p.A21V|ZNF331_ENST00000411977.2_Missense_Mutation_p.A21V|ZNF331_ENST00000511593.2_Missense_Mutation_p.A21V|ZNF331_ENST00000512387.1_Missense_Mutation_p.A21V	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GAGGAGTGGGCCTGTCTGAAC	0.502000			T	?	follicular thyroid adenoma								69	1047					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7615219	7615219	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:7615219C>T	ENST00000221249.6	+	18	2164	c.1733C>T	c.(1732-1734)gCg>gTg	p.A578V	PNPLA6_ENST00000414982.3_Missense_Mutation_p.A626V|PNPLA6_ENST00000450331.3_Missense_Mutation_p.A578V|PNPLA6_ENST00000594864.1_3'UTR|PNPLA6_ENST00000600737.1_Missense_Mutation_p.A617V|PNPLA6_ENST00000545201.2_Missense_Mutation_p.A552V	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	617					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						GTGCTGAGTGCGGCGCACACG	0.642000													48	564					0	0	1	0	0
MIR509-1	0	broad.mit.edu	37	X	146342142	146342142	+	RNA	SNP	T	T	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:146342142T>A	ENST00000385265.1	-	0	1					NR_030236.1|NR_030586.1																						ACACACAGCATGTCTGAGGAT	0.433000													8	1407					0	0	1	0	0
HEY1	23462	broad.mit.edu	37	8	80677993	80677993	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:80677993C>T	ENST00000337919.5	-	5	550	c.357G>A	c.(355-357)gcG>gcA	p.A119A	HEY1_ENST00000354724.3_Silent_p.A115A|HEY1_ENST00000523976.1_Silent_p.A25A|HEY1_ENST00000435063.2_5'UTR	NM_001040708.1	NP_001035798.1	Q9Y5J3	HEY1_HUMAN	hes-related family bHLH transcription factor with YRPW motif 1	115					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.A115A(2)|p.A119A(1)	HEY1/NCOA2(10)	cervix(1)|kidney(2)|large_intestine(5)|lung(14)	22	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			CAAGGGCGTGCGCGTCAAAGT	0.488000			T	NCOA2	mesenchymal chondrosarcoma						OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	180					0	0	1	0	0
BMPR1A	657	broad.mit.edu	37	10	88649818	88649818	+	Splice_Site	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:88649818G>A	ENST00000372037.2	+	4	604		c.e4-1		BMPR1A_ENST00000480152.1_Splice_Site	NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA						BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						TTTGAATGCAGGACAGAATCT	0.363000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				108	121					0	0	1	0	0
SHMT2	6472	broad.mit.edu	37	12	57624691	57624691	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:57624691G>A	ENST00000328923.3	+	2	591	c.139G>A	c.(139-141)Gag>Aag	p.E47K	SHMT2_ENST00000554600.1_3'UTR|SHMT2_ENST00000414700.3_Missense_Mutation_p.E26K|SHMT2_ENST00000449049.3_Missense_Mutation_p.E26K|SHMT2_ENST00000393827.4_5'UTR|SHMT2_ENST00000557487.1_Missense_Mutation_p.E47K|SHMT2_ENST00000553474.1_Missense_Mutation_p.E26K	NM_001166356.1|NM_005412.5	NP_001159828.1|NP_005403.2	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2 (mitochondrial)	47						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GACAGGCCAGGAGAGCCTGTC	0.617000													7	638					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998635	72998635	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:72998635C>A	ENST00000322038.5	+	2	1722	c.1138C>A	c.(1138-1140)Cac>Aac	p.H380N	TSHZ1_ENST00000580243.1_Missense_Mutation_p.H425N	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	425						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		TGGCAGCTCCCACGACACGCT	0.597000													68	157					3.61411e-23	3.82129e-23	1	1	0
H3F3C	440093	broad.mit.edu	37	12	31944965	31944965	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:31944965C>T	ENST00000340398.3	-	1	210	c.136G>A	c.(136-138)Gtg>Atg	p.V46M		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	46					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						CGAAGCGCCACGGTCCCAGGC	0.607000										HNSCC(67;0.2)			126	232					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77797280	77797280	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:77797280C>T	ENST00000354212.4	-	15	2802	c.2549G>A	c.(2548-2550)cGc>cAc	p.R850H	MAGI2_ENST00000522391.1_Missense_Mutation_p.R850H|MAGI2_ENST00000419488.1_Missense_Mutation_p.R836H	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	850	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGCCCATTGCGGGCTGCGTG	0.547000													7	842					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73562521	73562521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:73562521C>T	ENST00000339362.5	+	18	3112	c.2665C>T	c.(2665-2667)Cga>Tga	p.R889*	NEO1_ENST00000261908.6_Nonsense_Mutation_p.R889*|NEO1_ENST00000558964.1_Nonsense_Mutation_p.R889*|NEO1_ENST00000560262.1_Nonsense_Mutation_p.R889*			Q92859	NEO1_HUMAN	neogenin 1	889	Fibronectin type-III 5.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TACAGACTCCCGATACTACAC	0.488000													156	168					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55035844	55035844	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:55035844T>C	ENST00000417545.2	+	4	660	c.574T>C	c.(574-576)Tac>Cac	p.Y192H		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	176						intracellular	zinc ion binding	p.Y192H(11)|p.Y176H(11)		endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AGACATATTATACAGGTGAGT	0.338000													5	219					0	0	1	0	0
ADAM11	4185	broad.mit.edu	37	17	42849820	42849820	+	Nonsense_Mutation	SNP	A	A	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:42849820A>T	ENST00000200557.6	+	8	833	c.664A>T	c.(664-666)Aga>Tga	p.R222*	ADAM11_ENST00000535346.1_Missense_Mutation_p.E23V	NM_002390.4	NP_002381.2	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	222					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				GCCGAGGCTGAGAAGGAAAAG	0.706000													3	39					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77614629	77614629	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:77614629A>G	ENST00000534064.1	-	17	2088	c.2054T>C	c.(2053-2055)tTg>tCg	p.L685S	INTS4_ENST00000535943.1_Missense_Mutation_p.L60S|AAMDC_ENST00000532481.1_Intron	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	685					snRNA processing	integrator complex	protein binding	p.L685S(3)	INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CTTCAAATACAAAGGGGCAGC	0.478000													4	113					0	0	1	0	0
LILRA2	0	broad.mit.edu	37	19	55086932	55086932	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:55086932C>T	ENST00000251377.3	+	6	998	c.865C>T	c.(865-867)Cac>Tac	p.H289Y	LILRA2_ENST00000391737.1_Missense_Mutation_p.H277Y|LILRA2_ENST00000391738.3_Missense_Mutation_p.H289Y|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.H289Y|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2									p.H289Y(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GAGCCCCTCCCACGGGGGCCA	0.647000													9	411					0	0	1	0	0
CDC23	8697	broad.mit.edu	37	5	137548883	137548883	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:137548883G>A	ENST00000394886.2	-	1	149	c.119C>T	c.(118-120)gCg>gTg	p.A40V	CDC23_ENST00000505120.1_Missense_Mutation_p.A40V|CDC23_ENST00000394884.3_Missense_Mutation_p.A40V	NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	40					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGTAAGGCCCGCAATAAGCAG	0.572000													6	591					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871070	170871070	+	Silent	SNP	G	G	A	rs142508797	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:170871070G>A	ENST00000392092.2	+	3	525	c.246G>A	c.(244-246)caG>caA	p.Q82Q	TBP_ENST00000540980.1_Silent_p.Q62Q|TBP_ENST00000230354.6_Silent_p.Q82Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	82	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.587000													4	96					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71790685	71790685	+	Silent	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:71790685G>A	ENST00000269500.5	-	8	1163	c.828C>T	c.(826-828)caC>caT	p.H276H	FBXO15_ENST00000419743.2_Silent_p.H352H	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	276										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTTGGTAGCCGTGCAGTCCAT	0.443000													6	327					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													9	241					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33411215	33411215	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:33411215C>T	ENST00000418600.2	+	15	2987	c.2886C>T	c.(2884-2886)caC>caT	p.H962H	SYNGAP1_ENST00000293748.5_Silent_p.H962H|SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000428982.2_Silent_p.H903H	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	962					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						accaccaccaccatcaccacc	0.657000													6	551					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													5	221					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144075960	144075960	+	Splice_Site	SNP	G	G	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:144075960G>A	ENST00000056217.5	+	14	4810		c.e14+1		ARHGEF5_ENST00000471847.2_Splice_Site	NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5						intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					AGCAGTGACGGTAAGCGGGAG	0.587000													6	599					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058248	11058248	+	RNA	SNP	G	G	A	rs8130203	by1000genomes	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr21:11058248G>A	ENST00000470054.1	-	0	399									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAGCACAAGGATAATGATAC	0.433000													11	516					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785492	12785493	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:12785492_12785493insT	ENST00000332530.3	+	3	598_599	c.372_373insT	c.(370-375)tagtttfs	p.*F124fs	AADACL3_ENST00000359318.5_Frame_Shift_Ins_p.*F194fs	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	194							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCTGCTACTGTTTTTTTCA	0.455													11	633	---	---	---	---					
CYP4Z2P	0	broad.mit.edu	37	1	47310359	47310360	+	RNA	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:47310359_47310360insT	ENST00000505841.1	-	0	1269					NR_002788.2																						CAAAAACAAAACCCTAGATATT	0.421													11	56	---	---	---	---					
CYP4Z2P	0	broad.mit.edu	37	1	47325313	47325315	+	RNA	DEL	GTT	GTT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:47325313_47325315delGTT	ENST00000505841.1	-	0	1204					NR_002788.2																						AAAAAAAAAAGTTGTTTTAAGAC	0.409													8	276	---	---	---	---					
BCL10	8915	broad.mit.edu	37	1	85736511	85736511	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:85736511delT	ENST00000370580.1	-	2	873	c.136delA	c.(136-138)tafs	p.I46fs		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	46	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding	p.I46fs*4(1)		haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		CTACTGAGTATTTTTTTTGCA	0.343			T	IGH@	MALT								7	356	---	---	---	---					
EPS8L3	79574	broad.mit.edu	37	1	110300579	110300580	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:110300579_110300580insT	ENST00000369805.3	-	9	1050_1051	c.821_822insA	c.(820-822)aaafs	p.K274fs	EPS8L3_ENST00000361965.4_Frame_Shift_Ins_p.K273fs|EPS8L3_ENST00000361852.4_Frame_Shift_Ins_p.K273fs|RP4-735C1.4_ENST00000431955.1_RNA	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	273						cytoplasm	protein binding	p.N274fs*33(2)		breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CCTGGTCCTTGTTTTTTTTCCC	0.545													7	406	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143210193	143210194	+	RNA	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:143210193_143210194insT	ENST00000412204.2	-	0	876_877				RP11-782C8.1_ENST00000438000.1_lincRNA																							GGCAGCATTTGTTTTTTTAACA	0.317													12	215	---	---	---	---					
SPRR4	163778	broad.mit.edu	37	1	152944390	152944392	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:152944390_152944392delGCA	ENST00000328051.2	+	2	73_75	c.24_26delGCA	c.(22-27)cgg>cg	p.RQ8del		NM_173080.1	NP_775103.1	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	8	Gln-rich.				keratinization|peptide cross-linking	cell cortex				lung(1)|prostate(1)	2	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			agcagcagcggcagcagcagcag	0.552													7	576	---	---	---	---					
SMG7	9887	broad.mit.edu	37	1	183515266	183515267	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr1:183515266_183515267insA	ENST00000367537.3	+	18	2680_2681	c.2485_2486insA	c.(2485-2487)aaafs	p.K829fs	SMG7_ENST00000515829.2_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000456731.2_Frame_Shift_Ins_p.K758fs|SMG7_ENST00000347615.2_Frame_Shift_Ins_p.K846fs|SMG7_ENST00000507469.1_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000508461.1_Frame_Shift_Ins_p.K804fs			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	846	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding	p.?(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						GCAGCCTCTAGAAAAAAAAATG	0.450													8	304	---	---	---	---					
SMC6	79677	broad.mit.edu	37	2	17898126	17898126	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:17898126delT	ENST00000448223.2	-	14	1497	c.1228delA	c.(1228-1230)tafs	p.I410fs	SMC6_ENST00000381272.4_Frame_Shift_Del_p.I436fs|SMC6_ENST00000402989.1_Frame_Shift_Del_p.I410fs|SMC6_ENST00000351948.4_Frame_Shift_Del_p.I410fs	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	410					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AACCAAGATATTTTTTTTTGT	0.343													7	230	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:26022304_26022306delCTG	ENST00000435504.4	-	5	644_646	c.351_353delCAG	c.(349-354)agt>ag	p.SS117del	ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000336112.4_In_Frame_Del_p.SS89del			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	117	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													7	554	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del|ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													8	226	---	---	---	---					
PLA2R1	0	broad.mit.edu	37	2	160801441	160801442	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:160801441_160801442insT	ENST00000283243.7	-	28	4325_4326	c.4119_4120insA	c.(4117-4122)aagcttfs	p.L1374fs	PLA2R1_ENST00000460710.1_5'UTR	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	1374	C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						CATATAAAGCCTTTTTTTTCTT	0.401													7	501	---	---	---	---					
RBM45	129831	broad.mit.edu	37	2	178988920	178988920	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr2:178988920delA	ENST00000286070.5	+	8	1227	c.1135delA	c.(1135-1137)aafs	p.K381fs		NM_152945.2	NP_694453.2	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	383					cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding	p.A382fs*7(2)|p.?(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			TCCATCATGCAAAAAAAAAGC	0.353													10	381	---	---	---	---					
PDCD6IP	10015	broad.mit.edu	37	3	33866811	33866811	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:33866811delT	ENST00000307296.3	+	5	972	c.595delT	c.(595-597)ttfs	p.F200fs	PDCD6IP_ENST00000457054.2_Frame_Shift_Del_p.F200fs			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	200	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						TCAAGAAGTATTTTTTTTAAA	0.368													7	441	---	---	---	---					
NKTR	4820	broad.mit.edu	37	3	42679035	42679036	+	Frame_Shift_Ins	INS	-	-	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:42679035_42679036insC	ENST00000232978.8	+	13	2027_2028	c.1839_1840insC	c.(1837-1842)agccccfs	p.SP613fs	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	613					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TGAGTGACAGTCCCCCCCCTTC	0.421													10	605	---	---	---	---					
QRICH1	54870	broad.mit.edu	37	3	49094314	49094316	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:49094314_49094316delTGC	ENST00000395443.2	-	3	1789_1791	c.1317_1319delGCA	c.(1315-1320)caa>ca	p.QQ439del	QRICH1_ENST00000424300.1_In_Frame_Del_p.QQ439del|QRICH1_ENST00000357496.2_In_Frame_Del_p.QQ439del|QRICH1_ENST00000479449.1_5'UTR	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	439	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		AACTTGGAgttgctgctgctgct	0.562													7	223	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	GAT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:53529193_53529195delGAT	ENST00000288139.3	+	0	118_120				CACNA1D_ENST00000422281.2_Start_Codon_Del|CACNA1D_ENST00000350061.5_Start_Codon_Del	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.581													13	382	---	---	---	---					
ABCC5	10057	broad.mit.edu	37	3	183665256	183665257	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr3:183665256_183665257insA	ENST00000334444.6	-	23	3509_3510	c.3269_3270insT	c.(3268-3270)tttfs	p.F1090fs	ABCC5_ENST00000265586.6_Frame_Shift_Ins_p.F1047fs	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1090	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CACACGTAAACAAAAAAAAAGG	0.530													7	106	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:15995680delT	ENST00000505450.1	-	15	2282	c.1670delA	c.(1669-1671)atfs	p.N557fs	PROM1_ENST00000540805.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000447510.2_Frame_Shift_Del_p.N566fs|PROM1_ENST00000543373.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000508167.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000510224.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000539194.1_Frame_Shift_Del_p.N566fs	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	566					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AGTGCCTCTATTTTTTTTGCA	0.428													7	449	---	---	---	---					
CCKAR	886	broad.mit.edu	37	4	26483672	26483674	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:26483672_26483674delCTG	ENST00000295589.3	-	5	1067_1069	c.873_875delCAG	c.(871-876)agg>ag	p.SR291del		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	291					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	GCGGTTGGCCCTGCTGCTGCTGC	0.606													8	700	---	---	---	---					
UGDH	7358	broad.mit.edu	37	4	39515752	39515753	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:39515752_39515753insA	ENST00000316423.6	-	3	556_557	c.214_215insT	c.(214-216)tacfs	p.Y72fs	UGDH_ENST00000507089.1_5'UTR|UGDH_ENST00000506179.1_Frame_Shift_Ins_p.Y72fs|UGDH_ENST00000515398.1_5'UTR|UGDH_ENST00000501493.2_Frame_Shift_Ins_p.Y72fs	NM_001184701.1|NM_003359.3	NP_001171630.1|NP_003350.1	O60701	UGDH_HUMAN	UDP-glucose 6-dehydrogenase	72					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity	p.S72fs*18(1)		breast(1)|central_nervous_system(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(2)	27					NADH(DB00157)	AATATTGGTAGAAAAAAAAAGA	0.297													13	730	---	---	---	---					
CLOCK	9575	broad.mit.edu	37	4	56304530	56304532	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:56304530_56304532delCTG	ENST00000309964.4	-	21	2528_2530	c.2278_2280delCAG	c.(2278-2280)del	p.Q760del	CLOCK_ENST00000513440.1_In_Frame_Del_p.Q760del|CLOCK_ENST00000381322.1_In_Frame_Del_p.Q760del	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	760	Gln-rich.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			cctgggagctctgctgctgctgc	0.512													10	316	---	---	---	---					
UTP3	57050	broad.mit.edu	37	4	71554620	71554622	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:71554620_71554622delGAG	ENST00000254803.2	+	1	425_427	c.226_228delGAG	c.(226-228)del	p.E81del		NM_020368.2	NP_065101.1	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)	81	Glu-rich.				brain development|chromatin modification|gene silencing	nucleolus				endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(4)	18			Lung(101;0.235)			ggaggatggcgaggaggaggagg	0.567													11	231	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618484	89618486	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:89618484_89618486delTCC	ENST00000323061.5	-	1	900_902	c.420_422delGGA	c.(418-423)gaa>ga	p.EE142del	HERC3_ENST00000264345.3_Intron|HERC3_ENST00000543130.1_Intron|HERC3_ENST00000402738.1_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	142	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		gtactcctcttcctcctcctcct	0.606													10	416	---	---	---	---					
CXXC4	80319	broad.mit.edu	37	4	105412094	105412096	+	In_Frame_Del	DEL	GAG	GAG	-	rs146939312		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:105412094_105412096delGAG	ENST00000394767.2	-	2	1314_1316	c.864_866delCTC	c.(862-867)tcg>tc	p.SS290del	AC093628.1_ENST00000606234.1_RNA|CXXC4_ENST00000466963.1_Intron|CXXC4_ENST00000426831.1_In_Frame_Del_p.SS121del	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	121					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding	p.S120A(1)		kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGAGGAGGACGAGGAGGAGGAGG	0.606													8	551	---	---	---	---					
RRH	10692	broad.mit.edu	37	4	110756541	110756541	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:110756541delT	ENST00000317735.4	+	3	351	c.317delT	c.(316-318)atfs	p.I106fs		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	106					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		GGATTGAATATTTTTTTTGGA	0.393													7	463	---	---	---	---					
KIAA1109	84162	broad.mit.edu	37	4	123165029	123165029	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:123165029delA	ENST00000264501.4	+	31	5136	c.4763delA	c.(4762-4764)gafs	p.E1588fs	KIAA1109_ENST00000455637.1_Frame_Shift_Del_p.E1588fs|KIAA1109_ENST00000388738.3_Frame_Shift_Del_p.E1588fs			Q2LD37	K1109_HUMAN	KIAA1109	1588					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ACTCCATTGGAAAAAAAACTC	0.383													7	402	---	---	---	---					
SCLT1	132320	broad.mit.edu	37	4	129864163	129864163	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:129864163delT	ENST00000281142.5	-	17	2123	c.1620delA	c.(1618-1620)aafs	p.K540fs	SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	540						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TTACTTTGGCTTTTTTTTGAG	0.353													7	574	---	---	---	---					
OTUD4	54726	broad.mit.edu	37	4	146077123	146077125	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:146077123_146077125delCAG	ENST00000454497.2	-	8	595_597	c.458_460delCTG	c.(457-462)gat>g	p.AD153del	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_In_Frame_Del_p.AD218del	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	218	OTU.						protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					CCATTCACATCAGCAGCAGCAGC	0.340													7	438	---	---	---	---					
HMGB2	3148	broad.mit.edu	37	4	174253277	174253279	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:174253277_174253279delTCC	ENST00000296503.5	-	5	1455_1457	c.582_584delGGA	c.(580-585)gaa>ga	p.EE196del	HMGB2_ENST00000438704.2_In_Frame_Del_p.EE196del|HMGB2_ENST00000446922.2_In_Frame_Del_p.EE196del			P26583	HMGB2_HUMAN	high mobility group box 2	196	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding	p.E194E(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		atcttcttcttcctcctcctcct	0.468													7	505	---	---	---	---					
CCDC111	0	broad.mit.edu	37	4	185615905	185615914	+	Frame_Shift_Del	DEL	AACTAATTAT	AACTAATTAT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:185615905_185615914delAACTAATTAT	ENST00000314970.6	+	14	2088_2097	c.1655_1664delAACTAATTAT	c.(1654-1665)gafs	p.ELII552fs	CCDC111_ENST00000515774.1_Frame_Shift_Del_p.ELII423fs|CCDC111_ENST00000510864.1_3'UTR|CCDC111_ENST00000503752.1_Frame_Shift_Del_p.ELII552fs|CCDC111_ENST00000512834.1_Frame_Shift_Del_p.ELII551fs|MLF1IP_ENST00000281453.5_3'UTR	NM_152683.2	NP_689896.1	Q96LW4	CC111_HUMAN		552					DNA replication, synthesis of RNA primer		DNA primase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(2)	16		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		ATTCCTGATGAACTAATTATAGAAGTATTA	0.338													56	250	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190878555	190878556	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr4:190878555_190878556insA	ENST00000226798.4	+	6	657_658	c.435_436insA	c.(433-438)ggaaatfs	p.N146fs	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	146					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TCACTTAGGGGAAAATGGCTTT	0.351													7	133	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:32419951_32419953delGGT	ENST00000265069.8	-	3	495_497	c.393_395delACC	c.(391-396)ccc>cc	p.PP131del		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483													7	995	---	---	---	---					
C6	729	broad.mit.edu	37	5	41160299	41160300	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr5:41160299_41160300delAC	ENST00000263413.3	-	11	1892_1893	c.1628_1629delGT	c.(1627-1629)tfs	p.C543fs	C6_ENST00000337836.5_Frame_Shift_Del_p.C543fs	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	543	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGCCACTCTGACACACACACAG	0.475													7	626	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43323502	43323502	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:43323502delT	ENST00000361428.2	-	4	1647	c.1570delA	c.(1570-1572)ggfs	p.R526fs	ZNF318_ENST00000318149.3_Frame_Shift_Del_p.R526fs	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	526					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTACGTCGCCTTTTTTCCTGT	0.493													10	1682	---	---	---	---					
ICK	22858	broad.mit.edu	37	6	52883129	52883129	+	Splice_Site	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:52883129delT	ENST00000356971.3	-	8	1151	c.663_splice	c.e8+1	p.K221_splice	ICK_ENST00000350082.5_Splice_Site_p.K221_splice	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	221	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TATCATTACCTTTTTTGGTGT	0.502													7	706	---	---	---	---					
MTHFD1L	25902	broad.mit.edu	37	6	151358163	151358164	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr6:151358163_151358164insA	ENST00000367321.3	+	26	3031_3032	c.2757_2758insA	c.(2755-2760)gaaaaafs	p.EK919fs		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	919	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity	p.L914fs*14(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		ACCAACCTGACAAAAAAGGTGT	0.480													9	454	---	---	---	---					
MPP6	51678	broad.mit.edu	37	7	24705666	24705666	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:24705666delA	ENST00000396475.2	+	9	1209	c.910delA	c.(910-912)aafs	p.K308fs	MPP6_ENST00000409761.1_Frame_Shift_Del_p.K196fs|MPP6_ENST00000222644.4_Frame_Shift_Del_p.K308fs	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	308					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						TATAAGTAGCAAAAAAAAGAA	0.299													9	785	---	---	---	---					
TRGC1	0	broad.mit.edu	37	7	38301855	38301856	+	RNA	DEL	GT	GT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:38301855_38301856delGT	ENST00000443402.2	-	0	330					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TCAATTGTTCGTGTGTGTGTGT	0.356													9	515	---	---	---	---					
POU6F2	11281	broad.mit.edu	37	7	39379288	39379290	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:39379288_39379290delCAG	ENST00000518318.2	+	5	601_603	c.559_561delCAG	c.(559-561)del	p.Q196del	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_In_Frame_Del_p.Q196del|POU6F2_ENST00000559001.1_In_Frame_Del_p.Q188del			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	196	Gln-rich.			Q -> QQ (in Ref. 1; AAB49727/AAB49728).	central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						gctccagctccagcagcagcagc	0.616													7	129	---	---	---	---					
RP5-905H7.3	0	broad.mit.edu	37	7	62701951	62701952	+	RNA	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:62701951_62701952insA	ENST00000451381.1	-	0	55																											CTTTTTTGGAGAAAAAATATAT	0.337													7	12	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150814	65150815	+	RNA	INS	-	-	C			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:65150814_65150815insC	ENST00000430126.2	+	0	757																											TCTTCATCCCTCACCCCCCCCC	0.460													11	53	---	---	---	---					
PMS2P4	0	broad.mit.edu	37	7	66762432	66762432	+	RNA	DEL	G	G	-	rs60169909		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:66762432delG	ENST00000414507.1	-	0	184																											gtctcaaaaagaaaaaaaaaa	0.408													7	58	---	---	---	---					
TMEM60	85025	broad.mit.edu	37	7	77423460	77423460	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:77423460delT	ENST00000257663.3	-	2	607	c.231delA	c.(229-231)aafs	p.K77fs		NM_032936.3	NP_116325.1	Q9H2L4	TMM60_HUMAN	transmembrane protein 60	77						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)	4						GGTACCAGGCTTTTTTTTTAA	0.408													12	453	---	---	---	---					
ABCB4	5244	broad.mit.edu	37	7	87074281	87074282	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:87074281_87074282insA	ENST00000265723.4	-	10	1126_1127	c.1015_1016insT	c.(1015-1017)aatfs	p.N339fs	ABCB4_ENST00000358400.3_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000359206.3_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000545634.1_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000453593.1_Frame_Shift_Ins_p.N339fs	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	339	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.S339fs*3(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AATTAGGATTGAAAAAAAAACC	0.347													7	188	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91671392	91671393	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:91671392_91671393delAG	ENST00000359028.2	+	20	5211_5212	c.4986_4987delAG	c.(4984-4989)tcagfs	p.SE1662fs	AKAP9_ENST00000358100.2_Frame_Shift_Del_p.SE1662fs|AKAP9_ENST00000356239.3_Frame_Shift_Del_p.SE1650fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1662					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACCTGGTTTCAGAGAGAGAGAG	0.411			T	BRAF	papillary thyroid								7	476	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100281686	100281688	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:100281686_100281688delGCT	ENST00000275732.5	-	15	3032_3034	c.1823_1825delAGC	c.(1822-1827)ctc>c	p.QL608del		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	608	Gln-rich.|Poly-Gln.									central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AATGCCGTGAGCTGCTGCTGCTG	0.690													8	127	---	---	---	---					
TRBV7-8	0	broad.mit.edu	37	7	142099805	142099806	+	RNA	DEL	AC	AC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:142099805_142099806delAC	ENST00000390359.3	-	0	88																											TAGTCATcatacacacacacac	0.441													18	265	---	---	---	---					
PRSS3P2	0	broad.mit.edu	37	7	142481743	142481745	+	RNA	DEL	CTA	CTA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr7:142481743_142481745delCTA	ENST00000603901.1	+	0	454					NR_001296.3																						ACCCACATTTCTACTTTCTTTAT	0.517													9	427	---	---	---	---					
FAM66B	0	broad.mit.edu	37	8	7191540	7191541	+	RNA	DEL	CA	CA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:7191540_7191541delCA	ENST00000606573.1	-	0	703																											GGGGTGcacgcacacacacaca	0.530													7	80	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48746799	48746799	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:48746799delT	ENST00000314191.2	-	60	8163	c.8107delA	c.(8107-8109)ggfs	p.R2703fs	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Frame_Shift_Del_p.R2703fs	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2704	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGGCCCAGCCTTTTTTTCCCA	0.498								Non-homologous end-joining					7	1091	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	GGGGGTGCAAGGTGA	-	rs11270020		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	ENST00000308860.6	+	12	1301_1311	c.1267_splice	c.e12+1	p.L419_splice		NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	419	Protein kinase.					integral to membrane	protein serine/threonine kinase activity	p.?(2)		endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.730													7	8	---	---	---	---					
SMARCA2	6595	broad.mit.edu	37	9	2039777	2039779	+	In_Frame_Del	DEL	CAG	CAG	-	rs113070757	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:2039777_2039779delCAG	ENST00000382203.1	+	4	876_878	c.667_669delCAG	c.(667-669)del	p.Q238del	SMARCA2_ENST00000382194.1_In_Frame_Del_p.Q238del|SMARCA2_ENST00000357248.2_In_Frame_Del_p.Q238del|SMARCA2_ENST00000491574.1_3'UTR|SMARCA2_ENST00000349721.2_In_Frame_Del_p.Q238del			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	238	Poly-Gln.			Missing (in Ref. 1; CAA51407).	chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		gcagcagcaacagcagcagcagc	0.635													8	91	---	---	---	---					
C9orf131	138724	broad.mit.edu	37	9	35043650	35043650	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:35043650delC	ENST00000312292.5	+	2	1071	c.1024delC	c.(1024-1026)ccfs	p.P343fs	C9orf131_ENST00000354479.5_Frame_Shift_Del_p.P270fs|C9orf131_ENST00000421362.2_Frame_Shift_Del_p.P295fs	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	343										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCCGATGCCACCCCCCTGCCA	0.527													9	1852	---	---	---	---					
CTSV	1515	broad.mit.edu	37	9	99799590	99799590	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:99799590delG	ENST00000259470.5	-	4	589	c.340delC	c.(340-342)ttfs	p.L114fs	CTSV_ENST00000479932.1_5'UTR|CTSV_ENST00000538255.1_Frame_Shift_Del_p.L114fs	NM_001333.3	NP_001324.2			cathepsin V																		GATTTGGGAAGATCAAGAAAC	0.478													127	268	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)del	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													10	64	---	---	---	---					
ZNF462	58499	broad.mit.edu	37	9	109689690	109689690	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:109689690delC	ENST00000277225.5	+	3	3786	c.3497delC	c.(3496-3498)tcfs	p.S1166fs	ZNF462_ENST00000441147.2_Frame_Shift_Del_p.S11fs|ZNF462_ENST00000457913.1_Frame_Shift_Del_p.S1166fs			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1166					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCCCAAGGCTCCCCCCGGCCA	0.542													8	883	---	---	---	---					
COL5A1	1289	broad.mit.edu	37	9	137693829	137693829	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:137693829delC	ENST00000371817.3	+	38	3396	c.2982delC	c.(2980-2982)ggfs	p.G994fs		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	994	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.G997fs*17(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GCCCTCCAGGCCCCCCCGGCG	0.657													7	505	---	---	---	---					
EXD3	54932	broad.mit.edu	37	9	140267462	140267462	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr9:140267462delG	ENST00000340951.4	-	5	552	c.357delC	c.(355-357)ccfs	p.P119fs	EXD3_ENST00000479452.1_Frame_Shift_Del_p.P119fs|EXD3_ENST00000475006.1_5'UTR|EXD3_ENST00000342129.4_5'UTR	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	119					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						CCGCAAGGCTGGGGGGGCTCT	0.647													7	615	---	---	---	---					
CUBN	8029	broad.mit.edu	37	10	17113554	17113554	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:17113554delA	ENST00000377833.4	-	19	2561	c.2496delT	c.(2494-2496)ttfs	p.F832fs		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	832	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACACGTTAGGAAAAAAAGGCG	0.413													8	256	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													17	257	---	---	---	---					
JMJD1C	221037	broad.mit.edu	37	10	64952699	64952699	+	Splice_Site	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:64952699delT	ENST00000399262.2	-	16	6293	c.6076_splice	c.e16+1	p.K2025_splice	JMJD1C_ENST00000399251.1_3'UTR|JMJD1C_ENST00000542921.1_Splice_Site_p.K1843_splice|JMJD1C_ENST00000402544.1_Splice_Site_p.K1788_splice	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	2025					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TATGTTTACCTTTTTTTTCCT	0.373													8	330	---	---	---	---					
TNKS2	80351	broad.mit.edu	37	10	93601945	93601946	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr10:93601945_93601946insA	ENST00000371627.4	+	16	2235_2236	c.1856_1857insA	c.(1855-1857)aaafs	p.K619fs		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	619					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding	p.N622fs*29(1)		biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				GCAGACCCTACAAAAAAAAACA	0.391													9	220	---	---	---	---					
AP2A2	161	broad.mit.edu	37	11	970195	970195	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:970195delA	ENST00000448903.2	+	3	304	c.163delA	c.(163-165)aafs	p.K57fs	AP2A2_ENST00000332231.5_Frame_Shift_Del_p.K57fs|AP2A2_ENST00000534328.1_Frame_Shift_Del_p.K57fs	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	57	Lipid-binding.				axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity	p.K57fs*24(1)		breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGCTATAGTAAAAAAAAGTA	0.488													7	448	---	---	---	---					
NUP98	4928	broad.mit.edu	37	11	3720389	3720389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:3720389delT	ENST00000324932.7	-	25	4352	c.3932delA	c.(3931-3933)acfs	p.N1311fs	NUP98_ENST00000355260.3_Frame_Shift_Del_p.N1311fs|NUP98_ENST00000359171.4_Frame_Shift_Del_p.N1311fs	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1328					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CACAGGGCTGTTTTTTTGGGT	0.512			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								8	794	---	---	---	---					
TRIM51HP	0	broad.mit.edu	37	11	55065032	55065032	+	RNA	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:55065032delT	ENST00000526016.1	-	0	393					NR_038174.2																						AAAGACTGCATTTTTTTTTAG	0.398													7	199	---	---	---	---					
MEN1	0	broad.mit.edu	37	11	64573203	64573205	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:64573203_64573205delCTC	ENST00000337652.1	-	8	1605_1607	c.1102_1104delGAG	c.(1102-1104)del	p.E368del	MEN1_ENST00000478548.1_5'UTR|MEN1_ENST00000443283.1_In_Frame_Del_p.E368del|MEN1_ENST00000312049.6_In_Frame_Del_p.E363del|MEN1_ENST00000377316.2_In_Frame_Del_p.E363del|MEN1_ENST00000394374.2_In_Frame_Del_p.E368del|MEN1_ENST00000315422.4_In_Frame_Del_p.E363del|MEN1_ENST00000394376.1_In_Frame_Del_p.E368del|MEN1_ENST00000377321.1_In_Frame_Del_p.E328del|MEN1_ENST00000377326.3_In_Frame_Del_p.E363del|MEN1_ENST00000377313.1_In_Frame_Del_p.E368del	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	368	Interaction with FANCD2.		Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.K362fs*2(1)		NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						CTTCAAAGAACTCCTTGTAGATC	0.601			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				193	264	---	---	---	---					
DDX10	1662	broad.mit.edu	37	11	108788635	108788637	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr11:108788635_108788637delTGA	ENST00000526794.1	+	17	2372_2374	c.2340_2342delTGA	c.(2338-2343)agt>ag	p.SD780del	DDX10_ENST00000322536.3_In_Frame_Del_p.SD780del			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	780							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGGATTGGAGtgatgatgatgat	0.355			T	NUP98	AML*								7	265	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:46320707_46320708delTC	ENST00000465950.1	-	1	3040_3041	c.1831_1832delGA	c.(1831-1833)afs	p.E611fs	SCAF11_ENST00000369367.3_Frame_Shift_Del_p.E926fs|SCAF11_ENST00000549162.1_Frame_Shift_Del_p.E734fs|SCAF11_ENST00000419565.2_Frame_Shift_Del_p.E926fs			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	926					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GGTTCTCCTTTCTCTCTCTCTC	0.446													13	1019	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:49087434_49087436delATG	ENST00000261900.3	-	9	1783_1785	c.1561_1563delCAT	c.(1561-1563)del	p.H521del		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGGTGATTATGATGATGATGA	0.443													18	1452	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													10	890	---	---	---	---					
OR6C75	390323	broad.mit.edu	37	12	55759192	55759192	+	Frame_Shift_Del	DEL	T	T	-	rs75456529		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:55759192delT	ENST00000343399.3	+	1	298	c.298delT	c.(298-300)ttfs	p.F102fs		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGCTCAGCTATTTTTTTTCAT	0.438													13	999	---	---	---	---					
OR6C75	390323	broad.mit.edu	37	12	55759486	55759486	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:55759486delT	ENST00000343399.3	+	1	592	c.592delT	c.(592-594)ttfs	p.F199fs		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L200fs*1(1)		endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						ACTCATGGCATTTTTTTTAGC	0.393													14	692	---	---	---	---					
MARS	4141	broad.mit.edu	37	12	57883053	57883053	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:57883053delT	ENST00000262027.5	+	3	338	c.204delT	c.(202-204)tafs	p.Y68fs	MARS_ENST00000315473.5_5'UTR|MARS_ENST00000447721.2_Intron	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	68					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TGGGCAGATATTTTTTTTTGT	0.488													10	335	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													7	1131	---	---	---	---					
C12orf42	374470	broad.mit.edu	37	12	103695960	103695960	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:103695960delG	ENST00000548048.1	-	9	1304	c.808delC	c.(808-810)gcfs	p.R270fs	C12orf42_ENST00000548883.1_Frame_Shift_Del_p.R337fs|C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000378113.2_Frame_Shift_Del_p.R337fs			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	337										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CGGGTTGGGCGGGGGGGTGCT	0.587													9	654	---	---	---	---					
HCFC2	29915	broad.mit.edu	37	12	104476535	104476535	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:104476535delA	ENST00000229330.4	+	7	1023	c.919delA	c.(919-921)aafs	p.K308fs		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	308					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity	p.N309fs*32(1)		breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						TCAGGAAGATAAAAAAAATTC	0.373													8	544	---	---	---	---					
GCN1L1	10985	broad.mit.edu	37	12	120595737	120595739	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:120595737_120595739delCTC	ENST00000300648.6	-	26	3013_3015	c.3001_3003delGAG	c.(3001-3003)del	p.E1001del		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1001					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCCATCCACTCCTCCTCCTCC	0.631													7	409	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr12:121134166_121134168delGAA	ENST00000228506.3	+	5	1125_1127	c.697_699delGAA	c.(697-699)del	p.E238del	MLEC_ENST00000412616.2_In_Frame_Del_p.RK154del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	238	Poly-Glu.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding	p.E233E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gaaagaagaggaagaagaagaag	0.458													20	856	---	---	---	---					
SACS	26278	broad.mit.edu	37	13	23914687	23914687	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr13:23914687delT	ENST00000382298.3	-	10	3916	c.3328delA	c.(3328-3330)ttfs	p.I1110fs	SACS_ENST00000382292.3_Frame_Shift_Del_p.I1110fs|SACS_ENST00000402364.1_Frame_Shift_Del_p.I360fs	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1110					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGGCTTCAATTTTTTTTGCC	0.383													15	921	---	---	---	---					
RBM26	64062	broad.mit.edu	37	13	79918806	79918807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr13:79918806_79918807insT	ENST00000438737.2	-	15	2621_2622	c.2181_2182insA	c.(2179-2184)aaaggafs	p.G728fs	RBM26_ENST00000438724.1_Frame_Shift_Ins_p.G704fs|RBM26_ENST00000267229.7_Frame_Shift_Ins_p.G701fs			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	728					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTACTTACCTGTTTTTTTTTCT	0.332													9	170	---	---	---	---					
OR11H12	440153	broad.mit.edu	37	14	19378219	19378219	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:19378219delG	ENST00000550708.1	+	1	698	c.626delG	c.(625-627)aafs	p.R209fs		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTGCCCCAAGAATCCAACTG	0.428													9	257	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20138372	20138372	+	RNA	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:20138372delG	ENST00000548261.1	+	0	391																											TGAAACAaaagaaagaaagaa	0.398													4	9	---	---	---	---					
IRF9	10379	broad.mit.edu	37	14	24633132	24633134	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:24633132_24633134delAGC	ENST00000396864.3	+	5	828_830	c.541_543delAGC	c.(541-543)del	p.S187del	IRF9_ENST00000557894.1_In_Frame_Del_p.S85del|RP11-468E2.4_ENST00000558468.1_3'UTR	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	187	Poly-Ser.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		AGACATTGGGagcagcagcagca	0.567													9	323	---	---	---	---					
BAZ1A	11177	broad.mit.edu	37	14	35331422	35331423	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:35331422_35331423insT	ENST00000360310.1	-	3	786_787	c.219_220insA	c.(217-222)aacaagfs	p.NK73fs	BAZ1A_ENST00000553853.1_5'UTR|BAZ1A_ENST00000382422.2_Frame_Shift_Ins_p.NK73fs|BAZ1A_ENST00000358716.4_Frame_Shift_Ins_p.NK73fs	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	73	Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.|WAC.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTCTGTCTTGCTTTTTTTTCTG	0.426													8	796	---	---	---	---					
ABHD12B	145447	broad.mit.edu	37	14	51370180	51370180	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:51370180delA	ENST00000337334.2	+	11	952	c.937delA	c.(937-939)aafs	p.K314fs	ABHD12B_ENST00000395752.1_Frame_Shift_Del_p.K207fs|ABHD12B_ENST00000353130.1_Frame_Shift_Del_p.K237fs|PYGL_ENST00000532462.1_Intron	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	314							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					GGAGTATGGGAAAAAGGTAAA	0.398													7	619	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:72190482_72190484delTCC	ENST00000555818.1	+	16	4738_4740	c.4390_4392delTCC	c.(4390-4392)del	p.S1468del	SIPA1L1_ENST00000381232.3_In_Frame_Del_p.S1447del|SIPA1L1_ENST00000358550.2_In_Frame_Del_p.S1447del|SIPA1L1_ENST00000537413.1_In_Frame_Del_p.S922del|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													19	682	---	---	---	---					
RBM25	58517	broad.mit.edu	37	14	73572607	73572608	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:73572607_73572608delAG	ENST00000261973.7	+	11	1480_1481	c.1195_1196delAG	c.(1195-1197)afs	p.R399fs	RBM25_ENST00000527432.1_Frame_Shift_Del_p.R399fs	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	399	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agagcgggaaagagagagagag	0.446													12	174	---	---	---	---					
GALC	2581	broad.mit.edu	37	14	88406276	88406276	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:88406276delT	ENST00000261304.2	-	16	1990	c.1884delA	c.(1882-1884)aafs	p.K628fs	GALC_ENST00000393568.4_Frame_Shift_Del_p.K605fs|GALC_ENST00000544807.2_Frame_Shift_Del_p.K572fs|GALC_ENST00000393569.2_Frame_Shift_Del_p.K602fs	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	628					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTGTATACCATTTTTTTGCTG	0.308													7	1036	---	---	---	---					
TTC8	123016	broad.mit.edu	37	14	89338724	89338726	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:89338724_89338726delCAA	ENST00000338104.6	+	13	1375_1377	c.1323_1325delCAA	c.(1321-1326)gtc>gt	p.VN441del	TTC8_ENST00000354441.6_In_Frame_Del_p.VN160del|TTC8_ENST00000345383.5_In_Frame_Del_p.VN415del|TTC8_ENST00000380656.2_In_Frame_Del_p.VN425del|TTC8_ENST00000536576.1_In_Frame_Del_p.VN186del|TTC8_ENST00000346301.4_In_Frame_Del_p.VN385del|TTC8_ENST00000358622.5_In_Frame_Del_p.VN227del			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	451					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						TGGCTCTGGTCAACAACAACAAC	0.537													7	555	---	---	---	---					
CHGA	1113	broad.mit.edu	37	14	93397924	93397926	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr14:93397924_93397926delGAG	ENST00000216492.5	+	6	965_967	c.685_687delGAG	c.(685-687)del	p.E236del	CHGA_ENST00000334654.4_Intron|CHGA_ENST00000553866.1_3'UTR	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	236					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AAAGAGAgaagaggaggaggagg	0.645													11	161	---	---	---	---					
RP11-69H14.6	0	broad.mit.edu	37	15	22332412	22332413	+	RNA	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:22332412_22332413insA	ENST00000558896.1	+	0	219_220																											TTGGCTTGATGAAAAAAAACAA	0.322													9	679	---	---	---	---					
ZNF106	64397	broad.mit.edu	37	15	42742957	42742957	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:42742957delA	ENST00000263805.4	-	2	1770	c.1444delT	c.(1444-1446)ccfs	p.S482fs	ZNF106_ENST00000565380.1_Intron|ZNF106_ENST00000565611.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		TCTCCAGGGGAAAAAAAATTT	0.393													7	753	---	---	---	---					
NARG2	79664	broad.mit.edu	37	15	60745782	60745782	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr15:60745782delA	ENST00000561114.1	-	9	1307	c.1145delT	c.(1144-1146)tcfs	p.F382fs	NARG2_ENST00000439632.1_Intron|NARG2_ENST00000261520.4_Intron	NM_001276385.1	NP_001263314.1	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	0						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						CCCTTAGGGGAAAAAAAAAGC	0.338													8	165	---	---	---	---					
MLST8	64223	broad.mit.edu	37	16	2258237	2258237	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:2258237delG	ENST00000569417.1	+	7	954	c.600delG	c.(598-600)acfs	p.T200fs	MLST8_ENST00000301725.7_Intron|MLST8_ENST00000565250.1_Frame_Shift_Del_p.T200fs|MLST8_ENST00000397124.1_Frame_Shift_Del_p.T200fs|MLST8_ENST00000564088.1_Frame_Shift_Del_p.T200fs|MLST8_ENST00000382450.4_Frame_Shift_Del_p.T199fs|MLST8_ENST00000561651.1_Intron|MLST8_ENST00000301724.10_Frame_Shift_Del_p.T200fs	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	200					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						GGAATCTGACGGGGGGCATTG	0.627													7	555	---	---	---	---					
UBN1	29855	broad.mit.edu	37	16	4910691	4910693	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:4910691_4910693delAGA	ENST00000396658.4	+	6	1401_1403	c.698_700delAGA	c.(697-702)gag>g	p.EK233del	UBN1_ENST00000262376.6_In_Frame_Del_p.EK233del|UBN1_ENST00000590769.1_In_Frame_Del_p.EK233del|UBN1_ENST00000545171.1_In_Frame_Del_p.EK233del	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	233	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity	p.K234E(1)		NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						GCCAGTAAGGAGAAGAAGAAGAA	0.453													8	742	---	---	---	---					
EIF3C	8663	broad.mit.edu	37	16	28734579	28734581	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:28734579_28734581delGAG	ENST00000331666.6	+	9	1057_1059	c.871_873delGAG	c.(871-873)del	p.E294del	EIF3C_ENST00000564243.1_In_Frame_Del_p.E284del|EIF3C_ENST00000395587.1_In_Frame_Del_p.E294del|EIF3C_ENST00000566501.1_In_Frame_Del_p.E294del|EIF3C_ENST00000566866.1_In_Frame_Del_p.E294del			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	294	Poly-Glu.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						GCGCCTGGATGAGGAGGAGGAGG	0.562													10	2368	---	---	---	---					
RP11-67H24.2	0	broad.mit.edu	37	16	32823636	32823637	+	RNA	INS	-	-	C	rs112857933		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:32823636_32823637insC	ENST00000569859.1	+	0	373																											TTGCTGGAGTGGATGTGACAGG	0.495													9	160	---	---	---	---					
SLC9A5	6553	broad.mit.edu	37	16	67300017	67300019	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:67300017_67300019delGAG	ENST00000299798.11	+	15	2172_2174	c.2107_2109delGAG	c.(2107-2109)del	p.E708del		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	708					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CGTGGAGTCTGAGGAGGAGGAGG	0.571													9	159	---	---	---	---					
ZFP90	146198	broad.mit.edu	37	16	68598462	68598463	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:68598462_68598463insA	ENST00000570495.1	+	5	2064_2065	c.1772_1773insA	c.(1771-1773)caafs	p.Q591fs	ZFP90_ENST00000563169.2_Frame_Shift_Ins_p.Q591fs|ZFP90_ENST00000398253.2_Frame_Shift_Ins_p.Q591fs|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	591					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		AGAGCCTTCCGAAAAAAAACCA	0.411													9	753	---	---	---	---					
SNAI3	333929	broad.mit.edu	37	16	88745006	88745007	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr16:88745006_88745007delGC	ENST00000332281.5	-	3	814_815	c.728_729delGC	c.(727-729)afs	p.S243fs	SNAI3-AS1_ENST00000563261.1_RNA	NM_178310.3	NP_840101.1	Q3KNW1	SNAI3_HUMAN	snail family zinc finger 3	243					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|kidney(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.048)		CAAAGGCCCTGCTGCAGTGCGA	0.639													26	95	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:27027202_27027204delAGC	ENST00000314616.6	+	34	4856_4858	c.4573_4575delAGC	c.(4573-4575)del	p.S1528del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.S1528del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													13	1114	---	---	---	---					
SUZ12P	0	broad.mit.edu	37	17	29096086	29096087	+	RNA	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:29096086_29096087insT	ENST00000582557.1	+	0	1381																											AATATTGGTAATTTTTTTTTTT	0.347													10	105	---	---	---	---					
SPAG9	9043	broad.mit.edu	37	17	49077041	49077041	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:49077041delT	ENST00000262013.7	-	14	1853	c.1645delA	c.(1645-1647)ggfs	p.R549fs	SPAG9_ENST00000505279.1_Frame_Shift_Del_p.R535fs|SPAG9_ENST00000510283.1_Frame_Shift_Del_p.R392fs|SPAG9_ENST00000357122.4_Frame_Shift_Del_p.R535fs	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	549					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm		p.R535fs*28(1)		NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			ATGCTTGACCTTTTTTTTTCC	0.323													13	270	---	---	---	---					
LRRC37A16P	0	broad.mit.edu	37	17	66141015	66141016	+	RNA	INS	-	-	A			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:66141015_66141016insA	ENST00000590019.1	-	0	70																											CCAAGATTTCTACAAAAAAAAA	0.322													8	369	---	---	---	---					
TNRC6C	57690	broad.mit.edu	37	17	76046980	76046980	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr17:76046980delA	ENST00000335749.4	+	3	2406	c.1837delA	c.(1837-1839)aafs	p.K614fs	TNRC6C_ENST00000544502.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000541771.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000301624.4_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000588061.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000588847.1_Frame_Shift_Del_p.K614fs	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	614	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGGGGATGGGAAAAAAAATGG	0.522													8	533	---	---	---	---					
SOGA2	23255	broad.mit.edu	37	18	8793004	8793004	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:8793004delC	ENST00000359865.3	+	8	2038	c.1896delC	c.(1894-1896)ggfs	p.G632fs	SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000306329.11_Intron|SOGA2_ENST00000517570.1_Intron|SOGA2_ENST00000400050.3_Intron|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	980																	AGCTCAGGGGCCCCCCCGTTT	0.552													12	890	---	---	---	---					
LMAN1	3998	broad.mit.edu	37	18	57013284	57013285	+	Splice_Site	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr18:57013284_57013285insT	ENST00000251047.5	-	8	1540		c.e8-1		LMAN1_ENST00000587940.1_Splice_Site	NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1						blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	CTGGTGTGGGCTTTTTTTTGGA	0.297													10	498	---	---	---	---					
UHRF1	29128	broad.mit.edu	37	19	4960949	4960949	+	RNA	DEL	T	T	-	rs147409935		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:4960949delT	ENST00000592666.1	+	0	3092							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		TTTGTCTTCCttttttttttt	0.343													9	5	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10262139	10262139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:10262139delT	ENST00000340748.4	-	23	2387	c.2152delA	c.(2152-2154)tgfs	p.M718fs	DNMT1_ENST00000540357.1_Frame_Shift_Del_p.M718fs|DNMT1_ENST00000359526.4_Frame_Shift_Del_p.M734fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	718					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCCTGGTGCATTTTTTTGGGT	0.507													11	835	---	---	---	---					
ZNF442	79973	broad.mit.edu	37	19	12461741	12461741	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:12461741delA	ENST00000242804.4	-	6	1240	c.658delT	c.(658-660)ggfs	p.W220fs	ZNF442_ENST00000438182.1_Frame_Shift_Del_p.W151fs	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						AAACTAGGCCAAAAAAAGGCT	0.403													8	829	---	---	---	---					
LSM14A	26065	broad.mit.edu	37	19	34710340	34710340	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:34710340delC	ENST00000544216.3	+	7	903	c.826delC	c.(826-828)ggfs	p.R276fs	LSM14A_ENST00000540746.2_Frame_Shift_Del_p.R235fs|LSM14A_ENST00000433627.5_Frame_Shift_Del_p.R276fs	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	276					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					TGGGGGTCATCGGGGTGGCAG	0.438													7	689	---	---	---	---					
ATP4A	495	broad.mit.edu	37	19	36054349	36054351	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:36054349_36054351delCTT	ENST00000262623.3	-	2	119_121	c.91_93delAAG	c.(91-93)del	p.K31del		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	31					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCCACCCGCCTTCTTCTTCTTG	0.601													8	1046	---	---	---	---					
SERTAD1	29950	broad.mit.edu	37	19	40929409	40929411	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:40929409_40929411delCTC	ENST00000357949.4	-	2	201_203	c.43_45delGAG	c.(43-45)del	p.E15del		NM_013376.3	NP_037508.2	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	15					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(2)|lung(1)|prostate(1)|skin(1)	5			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGGTTCCTTCTCCTCCTCCTCC	0.557													7	304	---	---	---	---					
LIPE-AS1	0	broad.mit.edu	37	19	43136362	43136363	+	RNA	DEL	TG	TG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:43136362_43136363delTG	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						TGAGTATGTATGTGTGTGTGTG	0.505													7	89	---	---	---	---					
MIR525	0	broad.mit.edu	37	19	54200829	54200830	+	RNA	INS	-	-	A	rs80268200		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:54200829_54200830insA	ENST00000384978.1	+	0	43_44					NR_030192.1																						TCTCTTATGTGAAAAAAAAGAA	0.421													7	537	---	---	---	---					
LILRB1	0	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr19:55146148_55146150delCTC	ENST00000396331.1	+	11	1774_1776	c.1417_1419delCTC	c.(1417-1419)del	p.L479del	LILRB1_ENST00000396317.1_In_Frame_Del_p.L463del|LILRB1_ENST00000396321.2_In_Frame_Del_p.L479del|LILRB1_ENST00000396327.3_In_Frame_Del_p.L480del|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000427581.2_In_Frame_Del_p.L529del|LILRB1_ENST00000396332.4_In_Frame_Del_p.L479del|LILRB1_ENST00000396315.1_In_Frame_Del_p.L480del|LILRB1_ENST00000448689.1_In_Frame_Del_p.L479del|LILRB1_ENST00000418536.2_In_Frame_Del_p.L463del|LILRB1_ENST00000324602.7_In_Frame_Del_p.L480del|LILRB1_ENST00000434867.2_In_Frame_Del_p.L479del	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	479					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.581										HNSCC(37;0.09)			19	316	---	---	---	---					
GZF1	64412	broad.mit.edu	37	20	23345921	23345923	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:23345921_23345923delGAG	ENST00000338121.5	+	2	978_980	c.901_903delGAG	c.(901-903)del	p.E306del	GZF1_ENST00000461789.1_3'UTR|GZF1_ENST00000544236.1_Intron|GZF1_ENST00000542987.1_Intron|GZF1_ENST00000377051.2_In_Frame_Del_p.E306del			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	306					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					ggaggaggaagaggaggaggagg	0.532													8	348	---	---	---	---					
KIF3B	9371	broad.mit.edu	37	20	30898763	30898765	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:30898763_30898765delGAG	ENST00000375712.3	+	2	1350_1352	c.1183_1185delGAG	c.(1183-1185)del	p.E399del	KIF3B_ENST00000418717.2_Intron	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	399	Poly-Glu.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGGTGGggaagaggaggaggagg	0.571													10	230	---	---	---	---					
NCOA6	23054	broad.mit.edu	37	20	33330968	33330970	+	In_Frame_Del	DEL	TGC	TGC	-	rs140426729	byFrequency	TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:33330968_33330970delTGC	ENST00000374796.2	-	12	5660_5662	c.3090_3092delGCA	c.(3088-3093)caa>ca	p.QQ1030del	NCOA6_ENST00000359003.2_In_Frame_Del_p.QQ1030del			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1030	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CATCATTtgttgctgctgctgct	0.576													10	494	---	---	---	---					
SALL4	57167	broad.mit.edu	37	20	50408526	50408526	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:50408526delG	ENST00000217086.4	-	2	607	c.496delC	c.(496-498)agfs	p.Q166fs	SALL4_ENST00000395997.3_Frame_Shift_Del_p.Q166fs|SALL4_ENST00000371539.3_Intron|SALL4_ENST00000483130.1_5'UTR	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	166					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTTATGTCCTGGGGGGTGGGT	0.577													10	1348	---	---	---	---					
GNAS-AS1	0	broad.mit.edu	37	20	57405217	57405218	+	RNA	INS	-	-	CATATGATAG			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr20:57405217_57405218insCATATGATAG	ENST00000424094.2	-	0	819				GNAS-AS1_ENST00000598163.1_RNA	NR_002785.2																						accaccaccactgctataccac	0.535													3	4	---	---	---	---					
GART	2618	broad.mit.edu	37	21	34882121	34882122	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chr21:34882121_34882122insT	ENST00000381831.3	-	18	2683_2684	c.2420_2421insA	c.(2419-2421)agcfs	p.S807fs	GART_ENST00000381815.4_Frame_Shift_Ins_p.S807fs|GART_ENST00000543717.1_Frame_Shift_Ins_p.S359fs|GART_ENST00000381839.3_Frame_Shift_Ins_p.S807fs	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	807	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding	p.K807fs*7(2)		NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	CCACTCTGGCCTTTTTTTTTTC	0.446													9	172	---	---	---	---					
CNKSR2	22866	broad.mit.edu	37	X	21627678	21627680	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:21627678_21627680delGAG	ENST00000425654.2	+	19	3025_3027	c.2545_2547delGAG	c.(2545-2547)del	p.E856del	CNKSR2_ENST00000279451.4_In_Frame_Del_p.E886del|CNKSR2_ENST00000379510.3_In_Frame_Del_p.E886del|CNKSR2_ENST00000543067.1_In_Frame_Del_p.E837del	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	886					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						ggtggaggaagaggaggaggagg	0.517													12	218	---	---	---	---					
ZFX	7543	broad.mit.edu	37	X	24229134	24229134	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:24229134delA	ENST00000379177.1	+	11	2486	c.2059delA	c.(2059-2061)aafs	p.K688fs	ZFX_ENST00000338565.3_Frame_Shift_Del_p.K638fs|ZFX_ENST00000540034.1_Frame_Shift_Del_p.K727fs|ZFX_ENST00000539115.1_Frame_Shift_Del_p.K459fs|ZFX_ENST00000379188.3_Frame_Shift_Del_p.K688fs|ZFX_ENST00000304543.5_Frame_Shift_Del_p.K688fs	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	688					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						CCACAAGGGCAAAAAAATGCA	0.428													8	748	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165595	50165596	+	RNA	INS	-	-	AC	rs59226442		TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													10	59	---	---	---	---					
FAM120C	54954	broad.mit.edu	37	X	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:54209302_54209303insGGCGGC	ENST00000375180.2	-	1	385_386	c.329_330insGCCGCC	c.(328-330)ccc>cGCCGCCcc	p.109_110insRR	FAM120C_ENST00000477084.1_In_Frame_Ins_p.109_110insRR|FAM120C_ENST00000328235.4_In_Frame_Ins_p.109_110insRR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	109										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCAGCTGAGGGGGCGGCGGCGG	0.748													7	37	---	---	---	---					
GNL3L	54552	broad.mit.edu	37	X	54578339	54578341	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:54578339_54578341delGAA	ENST00000336470.4	+	12	1252_1254	c.1113_1115delGAA	c.(1111-1116)ggg>gg	p.GK371del	GNL3L_ENST00000360845.2_In_Frame_Del_p.GK371del	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	371					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						ACCGTTTGGGGAAGAAGAAGAAG	0.557													8	459	---	---	---	---					
TSIX	0	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													10	630	---	---	---	---					
PAK3	5063	broad.mit.edu	37	X	110406206	110406208	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:110406206_110406208delGAA	ENST00000519681.1	+	10	1037_1039	c.595_597delGAA	c.(595-597)del	p.E203del	PAK3_ENST00000372010.1_In_Frame_Del_p.E197del|PAK3_ENST00000262836.4_In_Frame_Del_p.E197del|PAK3_ENST00000372007.4_In_Frame_Del_p.E182del|PAK3_ENST00000425146.1_In_Frame_Del_p.E182del|PAK3_ENST00000518291.1_In_Frame_Del_p.E218del|PAK3_ENST00000446737.1_In_Frame_Del_p.E182del|PAK3_ENST00000360648.4_In_Frame_Del_p.E218del|PAK3_ENST00000417227.1_In_Frame_Del_p.E203del			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						agatgaagaggaagaagaagaag	0.394										TSP Lung(19;0.15)			7	748	---	---	---	---					
MAP7D3	79649	broad.mit.edu	37	X	135314194	135314194	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:135314194delG	ENST00000316077.9	-	8	1142	c.922delC	c.(922-924)agfs	p.Q308fs	MAP7D3_ENST00000370661.1_Frame_Shift_Del_p.Q273fs|MAP7D3_ENST00000370663.5_Frame_Shift_Del_p.Q290fs	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	308						cytoplasm|spindle				central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(1)	44	Acute lymphoblastic leukemia(192;0.000127)					ACATTCACCTGGGGGGGTGCA	0.532													8	1515	---	---	---	---					
GPR112	139378	broad.mit.edu	37	X	135455156	135455156	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:135455156delG	ENST00000394143.1	+	15	8000	c.7709delG	c.(7708-7710)cgfs	p.R2570fs	GPR112_ENST00000394141.1_Frame_Shift_Del_p.R2365fs|GPR112_ENST00000370652.1_Frame_Shift_Del_p.R2570fs|GPR112_ENST00000287534.4_Frame_Shift_Del_p.R2368fs|GPR112_ENST00000412101.1_Frame_Shift_Del_p.R2365fs	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2570					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R2570L(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GCTGTGCTGCGGGGGGACCAC	0.532													7	1944	---	---	---	---					
SPANXN2	494119	broad.mit.edu	37	X	142803692	142803692	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:142803692delT	ENST00000370498.1	-	1	824	c.71delA	c.(70-72)atfs	p.N24fs		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	24										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TACCTCATCATTTTTTTTGTT	0.443													10	990	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:150817142_150817144delGCT	ENST00000370357.4	+	9	930_932	c.685_687delGCT	c.(685-687)del	p.A236del		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													16	761	---	---	---	---					
MAGEA10	4109	broad.mit.edu	37	X	151303906	151303908	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-3A-A9IN-01A-11D-A397-08	TCGA-3A-A9IN-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d19332b-2cfd-4fb7-85d9-96d08e5ba837	3f450d7d-d471-4b97-8a4c-696789306e4d	g.chrX:151303906_151303908delAGG	ENST00000370323.4	-	4	501_503	c.185_187delCCT	c.(184-189)tgc>t	p.SC62del	MAGEA10_ENST00000244096.3_In_Frame_Del_p.SC62del|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	62	Poly-Ser.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGGATAGCaggaggaggagga	0.562													9	583	---	---	---	---