Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRY	10129	broad.mit.edu	37	13	32841383	32841383	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr13:32841383G>A	ENST00000380250.3	+	55	8519	c.8023G>A	c.(8023-8025)Gca>Aca	p.A2675T	FRY_ENST00000542859.1_Missense_Mutation_p.A45T	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2675					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTTCAGCCCGCAGCCTGTGA	0.547000													7	865					0	0	1	0	0
LRRC42	115353	broad.mit.edu	37	1	54426130	54426130	+	Missense_Mutation	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:54426130C>A	ENST00000371370.3	+	5	1228	c.707C>A	c.(706-708)aCa>aAa	p.T236K	LRRC42_ENST00000319223.4_Missense_Mutation_p.T236K	NM_001256409.1	NP_001243338.1	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	236										breast(2)|kidney(1)|large_intestine(1)|lung(5)	9						GAGAATCTAACATTATTAGAC	0.373000													76	130					1.7488e-33	1.9789e-33	1	1	0
FAM83G	644815	broad.mit.edu	37	17	18882872	18882872	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:18882872C>T	ENST00000388995.6	-	4	1028	c.805G>A	c.(805-807)Ggc>Agc	p.G269S	SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000417251.2_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.G269S|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395643.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.G269S|SLC5A10_ENST00000395642.1_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	269										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						CTGTAGGAGCCGCACACAGCC	0.577000													4	240					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124298029	124298029	+	Missense_Mutation	SNP	C	C	T	rs138397621	byFrequency	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:124298029C>T	ENST00000409039.3	+	19	3134	c.3109C>T	c.(3109-3111)Cgc>Tgc	p.R1037C		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1037	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R1037C(1)|p.R855C(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGAGGTTATGCGCCACCCTCT	0.443000													5	474					0	0	1	0	0
EPC1	80314	broad.mit.edu	37	10	32561075	32561075	+	Missense_Mutation	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr10:32561075C>G	ENST00000319778.6	-	12	2186	c.1884G>C	c.(1882-1884)ttG>ttC	p.L628F	EPC1_ENST00000263062.8_Missense_Mutation_p.L651F|EPC1_ENST00000375110.2_Missense_Mutation_p.L578F	NM_001272004.1|NM_001272019.1	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	651					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				TAGCAGAATCCAAAGTCTTAG	0.368000													114	19					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319592	21319592	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:21319592G>A	ENST00000583088.1	+	3	1833	c.938G>A	c.(937-939)cGc>cAc	p.R313H	KCNJ12_ENST00000331718.5_Missense_Mutation_p.R313H	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		ACCCAGGCCCGCAGCTCCTAC	0.592000										Prostate(3;0.18)			5	627					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133364801	133364801	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:133364801G>A	ENST00000372394.1	+	13	1401	c.920G>A	c.(919-921)cGc>cAc	p.R307H	ASS1_ENST00000352480.5_Missense_Mutation_p.R307H|ASS1_ENST00000372393.3_Missense_Mutation_p.R307H			P00966	ASSY_HUMAN	argininosuccinate synthase 1	307			R -> C (in CTLN1).		arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	CGGGAAGTGCGCAAAATCAAA	0.532000													6	846					0	0	1	0	0
SRP9	6726	broad.mit.edu	37	1	225971060	225971060	+	Missense_Mutation	SNP	A	A	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:225971060A>T	ENST00000366839.4	+	2	235	c.131A>T	c.(130-132)gAt>gTt	p.D44V	SRP9_ENST00000304786.7_Missense_Mutation_p.D44V|SRP9_ENST00000366838.1_Missense_Mutation_p.D44V	NM_001130440.1	NP_001123912.1	P49458	SRP09_HUMAN	signal recognition particle 9kDa	44					negative regulation of translational elongation|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			endometrium(1)|kidney(1)|skin(1)	3						AAAGTAACAGATGATTTAGTT	0.279000													89	34					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16378296	16378296	+	Silent	SNP	A	A	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:16378296A>C	ENST00000375679.4	+	14	1500	c.1389A>C	c.(1387-1389)ccA>ccC	p.P463P	CLCNKB_ENST00000375667.3_Silent_p.P294P	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CCATCATGCCAGGGGGGTATG	0.622000													9	207					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47642587	47642587	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr21:47642587G>A	ENST00000397728.3	-	4	463	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	LSS_ENST00000356396.4_Missense_Mutation_p.R129W|LSS_ENST00000522411.1_Missense_Mutation_p.R129W|LSS_ENST00000464357.1_5'UTR|LSS_ENST00000457828.2_Missense_Mutation_p.R49W	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	129					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					CGCAGGTACCGCACAATCTCT	0.592000													4	139					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7796784	7796784	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:7796784G>A	ENST00000380358.4	+	5	868	c.867G>A	c.(865-867)tcG>tcA	p.S289S	CHD3_ENST00000358181.4_Silent_p.S230S|CHD3_ENST00000330494.7_Silent_p.S230S	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	230					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CTGTCTCGTCGGCCACCCCCA	0.657000													4	121					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228486354	228486354	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:228486354G>A	ENST00000570156.2	+	49	13220	c.13146G>A	c.(13144-13146)gcG>gcA	p.A4382A	OBSCN_ENST00000422127.1_Intron|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000366707.4_Silent_p.A1072A|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3425	Ig-like 45.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGTCTGTGGCGGATGCTGGGG	0.562000													4	133					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72877251	72877251	+	Splice_Site	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:72877251C>A	ENST00000339594.4	-	12	3588		c.e12+1		BAZ1B_ENST00000404251.1_Splice_Site	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B						ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TATATTCCTACCCGGGCTTCA	0.418000													7	577					1.12685e-05	1.21136e-05	1	1	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													6	201					0	0	1	0	0
CABLES2	81928	broad.mit.edu	37	20	60970037	60970037	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:60970037G>A	ENST00000279101.5	-	4	569	c.561C>T	c.(559-561)tgC>tgT	p.C187C		NM_031215.2	NP_112492.2	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	187					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			endometrium(2)|kidney(1)|lung(6)|pancreas(1)|skin(1)	11	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			AGAAGGCCGCGCACAGGGACC	0.657000													4	222					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50805690	50805690	+	Missense_Mutation	SNP	C	C	A	rs80338914		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr6:50805690C>A	ENST00000263046.4	+	6	1017	c.851C>A	c.(850-852)gCc>gAc	p.A284D	TFAP2B_ENST00000393655.3_Missense_Mutation_p.A275D			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	275					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					AATTTCAGAGCCAAATCGAAA	0.423000													5	356					1	1	1	1	0
SERPINA5	5104	broad.mit.edu	37	14	95058575	95058575	+	Nonstop_Mutation	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr14:95058575G>T	ENST00000329597.7	+	6	1430	c.1220G>T	c.(1219-1221)tGa>tTa	p.*407L	SERPINA5_ENST00000554276.1_Nonstop_Mutation_p.*407L|SERPINA5_ENST00000554866.1_Nonstop_Mutation_p.*407L|SERPINA5_ENST00000553780.1_Nonstop_Mutation_p.*407L|SERPINA3_ENST00000553947.1_Intron	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	AACCGCCCCTGAGGTGGGGCT	0.527000													12	1178					6.40141e-05	6.7687e-05	1	1	0
OR4C15	81309	broad.mit.edu	37	11	55322061	55322061	+	Silent	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:55322061C>A	ENST00000314644.2	+	1	279	c.279C>A	c.(277-279)ggC>ggA	p.G93G		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTGTTGGGGGCAACATGCTAA	0.433000										HNSCC(20;0.049)			6	434					2.7689e-08	3.0792e-08	1	1	0
HNF1B	6928	broad.mit.edu	37	17	36065033	36065033	+	Missense_Mutation	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:36065033C>A	ENST00000225893.4	-	6	1591	c.1230G>T	c.(1228-1230)ttG>ttT	p.L410F	HNF1B_ENST00000427275.2_Missense_Mutation_p.L384F|HNF1B_ENST00000561193.1_Missense_Mutation_p.L384F|HNF1B_ENST00000560016.1_Missense_Mutation_p.L410F	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	410					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TGACTGGGGGCAAACCTCCTC	0.488000													9	197					0.000274275	0.000280805	1	1	0
PTGES	9536	broad.mit.edu	37	9	132502126	132502126	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:132502126C>T	ENST00000340607.4	-	3	257	c.223G>A	c.(223-225)Gac>Aac	p.D75N	PTGES_ENST00000481476.1_5'UTR	NM_004878.4	NP_004869.1	O14684	PTGES_HUMAN	prostaglandin E synthase	75	Glutathione binding.				prostaglandin biosynthetic process|signal transduction	integral to membrane|membrane fraction	glutathione binding|prostaglandin-E synthase activity			lung(1)|skin(1)	2		Ovarian(14;0.00556)				GTCTCCATGTCGTTCCGGTGG	0.572000													17	16					0	0	1	0	0
EIF5A2	56648	broad.mit.edu	37	3	170612210	170612210	+	Silent	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr3:170612210C>A	ENST00000295822.2	-	4	458	c.273G>T	c.(271-273)ctG>ctT	p.L91L	EIF5A2_ENST00000487522.1_Intron|EIF5A2_ENST00000474096.1_Intron|EIF5A2_ENST00000460117.1_5'UTR	NM_020390.5	NP_065123.1	Q9GZV4	IF5A2_HUMAN	eukaryotic translation initiation factor 5A2	91					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	3	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)			GAATGCATATCAGCTATTAGA	0.343000													4	199					0.00024832	0.000258333	1	1	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72663998	72663998	+	RNA	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:72663998T>G	ENST00000425256.1	-	0	902					NR_002164.1																						ATAGCCGGGGTCCTTGAATAC	0.488000													5	231					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67018081	67018081	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:67018081G>A	ENST00000529006.2	+	17	3026	c.2580G>A	c.(2578-2580)gaG>gaA	p.E860E	KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_Intron|KDM2A_ENST00000530342.1_Silent_p.E421E|KDM2A_ENST00000308783.5_Silent_p.E318E	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	860					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						aggaggaagaggaggaggagg	0.657000													4	82					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235710	127235710	+	Missense_Mutation	SNP	G	G	A	rs143868079	by1000genomes	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:127235710G>A	ENST00000265825.5	+	2	713	c.494G>A	c.(493-495)cGc>cAc	p.R165H	FSCN3_ENST00000420086.2_Missense_Mutation_p.R31H	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	165						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ACTATGGGCCGCATCTGGGTG	0.612000													6	388					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166946577	166946577	+	Silent	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:166946577G>T	ENST00000061240.2	+	9	1799	c.1152G>T	c.(1150-1152)ggG>ggT	p.G384G	TLL1_ENST00000513213.1_Silent_p.G384G|TLL1_ENST00000507499.1_Silent_p.G384G	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	384	CUB 1.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGACCCCAGGGGAGAAGGTAG	0.388000													133	161					5.75948e-69	6.69346e-69	1	1	0
INSRR	3645	broad.mit.edu	37	1	156812204	156812204	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:156812204G>A	ENST00000368195.3	-	18	3619	c.3223C>T	c.(3223-3225)Cgg>Tgg	p.R1075W	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1075	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCTCAGGCCGCAAAGATCGA	0.602000													5	277					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													6	182					0	0	1	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639635	149639635	+	Missense_Mutation	SNP	A	A	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:149639635A>T	ENST00000370401.2	+	4	2100	c.1790A>T	c.(1789-1791)cAg>cTg	p.Q597L	MAMLD1_ENST00000432680.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000426613.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000455522.2_Missense_Mutation_p.Q78L|MAMLD1_ENST00000262858.5_Missense_Mutation_p.Q597L			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	597	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TTgcagctgcagcagcagcag	0.607000													4	243					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52598121	52598121	+	Missense_Mutation	SNP	A	A	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr3:52598121A>C	ENST00000356770.4	-	22	3726	c.3724T>G	c.(3724-3726)Ttg>Gtg	p.L1242V	PBRM1_ENST00000409767.1_Missense_Mutation_p.L1289V|PBRM1_ENST00000409057.1_Missense_Mutation_p.L1274V|PBRM1_ENST00000337303.4_Missense_Mutation_p.L1274V|SMIM4_ENST00000476842.1_Intron|PBRM1_ENST00000410007.1_Missense_Mutation_p.L1249V|PBRM1_ENST00000296302.7_Missense_Mutation_p.L1274V|PBRM1_ENST00000394830.3_Missense_Mutation_p.L1249V|PBRM1_ENST00000409114.3_Missense_Mutation_p.L1289V			Q86U86	PB1_HUMAN	polybromo 1	1274	BAH 2.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AACCTCTTCAATCCTTTGAAT	0.393000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								63	205					0	0	1	0	0
TVP23C	201158	broad.mit.edu	37	17	15441469	15441469	+	Splice_Site	SNP	C	C	T	rs139351610	by1000genomes	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:15441469C>T	ENST00000584811.1	-	7	1815		c.e7-2		TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000438826.3_Splice_Site|TVP23C_ENST00000519970.1_Intron|TVP23C_ENST00000428082.2_Splice_Site|TVP23C_ENST00000225576.3_Intron					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		TCCAGTGTTCCGCAAAAGACA	0.393000													5	309					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44611966	44611966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:44611966G>A	ENST00000336976.6	+	6	1907	c.1653G>A	c.(1651-1653)tgG>tgA	p.W551*	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	551					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				GTTTTGGCTGGGCCTCGTGTC	0.413000													121	390					0	0	1	0	0
FUT6	2528	broad.mit.edu	37	19	5831898	5831898	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:5831898G>A	ENST00000318336.4	-	3	1875	c.681C>T	c.(679-681)ccC>ccT	p.P227P	FUT6_ENST00000592563.1_Silent_p.P227P|FUT6_ENST00000527106.1_Silent_p.P227P|FUT6_ENST00000524754.1_Silent_p.P227P|FUT6_ENST00000286955.5_Silent_p.P227P	NM_000150.2	NP_000141.1	P51993	FUT6_HUMAN	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	227					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)	6						CCTGGGGCAGGGGCTTGTGGG	0.612000													73	628					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70303923	70303923	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:70303923C>T	ENST00000310961.5	+	8	923	c.505C>T	c.(505-507)Cgg>Tgg	p.R169W	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000370958.1_Missense_Mutation_p.R202W|LRRC7_ENST00000035383.5_Missense_Mutation_p.R164W			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	164						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGTCAAATTGCGGATCTTGGA	0.299000													9	141					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162769621	162769621	+	Missense_Mutation	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:162769621T>G	ENST00000367917.3	+	5	604	c.536T>G	c.(535-537)tTc>tGc	p.F179C	HSD17B7_ENST00000254521.3_Missense_Mutation_p.F179C|HSD17B7_ENST00000485405.1_3'UTR			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	179					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	AAATCTAATTTCAGCCTCGAG	0.488000													110	15					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	93511319	93511319	+	Missense_Mutation	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:93511319G>T	ENST00000282020.4	+	2	384	c.126G>T	c.(124-126)gaG>gaT	p.E42D	GRID2_ENST00000505687.1_3'UTR|GRID2_ENST00000510992.1_Missense_Mutation_p.E42D	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	42					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGGATGATGAGGTATTTCGCA	0.378000													14	557					2.32078e-09	2.60331e-09	1	1	0
USP28	57646	broad.mit.edu	37	11	113679043	113679043	+	Missense_Mutation	SNP	C	C	T	rs143699311		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:113679043C>T	ENST00000003302.4	-	18	2349	c.2281G>A	c.(2281-2283)Ggt>Agt	p.G761S	USP28_ENST00000545540.1_Missense_Mutation_p.G636S|USP28_ENST00000260188.5_Missense_Mutation_p.G761S|USP28_ENST00000544967.1_Missense_Mutation_p.G469S	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	761					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.G761S(1)		breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GCTTCTACACCGCTCTTCTCA	0.522000													427	94					0	0	1	0	0
PTPN13	0	broad.mit.edu	37	4	87680211	87680211	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:87680211G>A	ENST00000436978.1	+	23	4018	c.3538G>A	c.(3538-3540)Gaa>Aaa	p.E1180K	PTPN13_ENST00000427191.2_Missense_Mutation_p.E1161K|PTPN13_ENST00000411767.2_Missense_Mutation_p.E1180K|PTPN13_ENST00000316707.6_Missense_Mutation_p.E989K|PTPN13_ENST00000511467.1_Missense_Mutation_p.E1180K	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1180						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAGCCAAAAGAAAAGATATC	0.373000													6	191					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39380781	39380781	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:39380781C>T	ENST00000249396.7	-	5	531	c.230G>A	c.(229-231)cGc>cAc	p.R77H	SIRT2_ENST00000358931.5_Missense_Mutation_p.R77H|SIRT2_ENST00000392081.2_Missense_Mutation_p.R40H	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	77	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			GATGACTCTGCGACCTGGAGG	0.557000													4	264					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99007736	99007736	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:99007736G>A	ENST00000342502.2	-	3	1091	c.680C>T	c.(679-681)aCg>aTg	p.T227M	IKBIP_ENST00000420861.1_Missense_Mutation_p.T121M|IKBIP_ENST00000393042.3_3'UTR	NM_201612.2	NP_963906.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	227					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						CTTTCGGAGCGTTGCTGTTCG	0.333000													19	416					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76905998	76905998	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr14:76905998G>A	ENST00000380887.2	+	2	374	c.302G>A	c.(301-303)cGc>cAc	p.R101H	ESRRB_ENST00000509242.1_Missense_Mutation_p.R101H|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Missense_Mutation_p.R101H|ESRRB_ENST00000261532.7_Missense_Mutation_p.R101H			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	101						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATCCCCAAGCGCCTGTGCCTC	0.622000													101	100					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10084482	10084482	+	Missense_Mutation	SNP	T	T	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:10084482T>C	ENST00000264828.3	-	49	3647	c.3562A>G	c.(3562-3564)Act>Gct	p.T1188A		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1188	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGCCCTGGAGTGCCCTGGAGA	0.597000													274	294					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790192	78790192	+	Missense_Mutation	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:78790192C>G	ENST00000376767.3	+	14	2559	c.2047C>G	c.(2047-2049)Cga>Gga	p.R683G	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ggaatggaatcgaatcgaatc	0.373000													5	33					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10298537	10298537	+	Silent	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:10298537C>A	ENST00000403437.2	-	34	4969	c.4875G>T	c.(4873-4875)ctG>ctT	p.L1625L	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1625					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCATTTCATTCAGATCTCCTT	0.463000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				7	686					2.0095e-06	2.2156e-06	1	1	0
CACNA1B	774	broad.mit.edu	37	9	140880925	140880925	+	Silent	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:140880925C>A	ENST00000371372.1	+	14	1975	c.1830C>A	c.(1828-1830)atC>atA	p.I610I	CACNA1B_ENST00000371355.4_Silent_p.I611I|CACNA1B_ENST00000371357.1_Silent_p.I611I|CACNA1B_ENST00000277551.2_Silent_p.I610I|CACNA1B_ENST00000371363.1_Silent_p.I610I|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	610					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGTCCATCATCAGCCTGCTCT	0.617000													60	83					3.00387e-57	3.45982e-57	1	1	0
DNMT1	1786	broad.mit.edu	37	19	10267152	10267152	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:10267152G>A	ENST00000340748.4	-	17	1501	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	DNMT1_ENST00000540357.1_Silent_p.I422I|DNMT1_ENST00000359526.4_Silent_p.I438I			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	422	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGCCGGTGTCGATGGGACACA	0.483000													5	351					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44699006	44699006	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:44699006G>A	ENST00000290231.6	-	3	372	c.208C>T	c.(208-210)Cgg>Tgg	p.R70W		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	70	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding	p.R70W(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CTGTGATCCCGCAAATCTCTA	0.562000													6	766					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129828687	129828687	+	Silent	SNP	T	T	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr6:129828687T>A	ENST00000421865.2	+	62	8806	c.8757T>A	c.(8755-8757)ccT>ccA	p.P2919P		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2919	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGAGGCCCCTGCCGATCTGG	0.478000													61	429					0	0	1	0	0
KLK10	5655	broad.mit.edu	37	19	51518155	51518155	+	Silent	SNP	C	C	T	rs138296032		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:51518155C>T	ENST00000309958.3	-	6	950	c.732G>A	c.(730-732)tcG>tcA	p.S244S	KLK10_ENST00000391805.1_Silent_p.S244S|KLK10_ENST00000358789.3_Silent_p.S244S	NM_002776.4	NP_002767.2	O43240	KLK10_HUMAN	kallikrein-related peptidase 10	244	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		AAACACCCCACGAGAGGATGC	0.537000													21	305					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48621345	48621345	+	Missense_Mutation	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:48621345C>G	ENST00000358350.4	-	7	961	c.357G>C	c.(355-357)agG>agC	p.R119S	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000537810.1_Missense_Mutation_p.R119S|FRYL_ENST00000503238.1_Missense_Mutation_p.R119S|FRYL_ENST00000507711.1_Missense_Mutation_p.R119S	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTGCTAAGTCCCTCCTTTCAA	0.328000													13	276					0	0	1	0	0
SLMO2	51012	broad.mit.edu	37	20	57613539	57613539	+	Silent	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:57613539C>T	ENST00000355937.4	-	2	361	c.183G>A	c.(181-183)ctG>ctA	p.L61L	SLMO2_ENST00000371033.5_Silent_p.L61L	NM_016045.2	NP_057129.2	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2 (Drosophila)	61	PRELI/MSF1.									endometrium(1)|lung(2)|skin(2)	5	all_lung(29;0.00711)		Colorectal(105;0.109)			CAATGGAAGGCAGTCCCCACT	0.443000													6	513					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19955543	19955543	+	Missense_Mutation	SNP	A	A	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:19955543A>G	ENST00000255006.6	+	8	1170	c.1021A>G	c.(1021-1023)Agc>Ggc	p.S341G	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	292					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GAAACGGCCGAGCACAAGGAC	0.612000													36	187					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101257	71101257	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr16:71101257G>A	ENST00000393567.2	-	15	2161	c.2011C>T	c.(2011-2013)Ctg>Ttg	p.L671L	HYDIN_ENST00000321489.5_Silent_p.L671L|HYDIN_ENST00000538248.1_Silent_p.L698L|HYDIN_ENST00000448089.2_Silent_p.L671L|HYDIN_ENST00000448691.1_Silent_p.L671L|HYDIN_ENST00000393550.2_Silent_p.L686L|HYDIN_ENST00000288168.10_Silent_p.L688L|HYDIN_ENST00000541601.1_Silent_p.L688L	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	671										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ACGAGTGCCAGCTCGTATTTC	0.532000													4	186					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104120022	104120022	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr10:104120022G>A	ENST00000369983.3	+	12	1519	c.1259G>A	c.(1258-1260)cGc>cAc	p.R420H	GBF1_ENST00000476019.1_Intron	NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	420					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CCACACGACCGCCATAACTCA	0.582000													7	750					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90857513	90857513	+	Silent	SNP	T	T	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:90857513T>A	ENST00000394980.1	+	7	3001	c.2682T>A	c.(2680-2682)ctT>ctA	p.L894L	MMRN1_ENST00000394981.1_Intron|MMRN1_ENST00000264790.2_Silent_p.L894L|MMRN1_ENST00000508372.1_Silent_p.L636L			Q13201	MMRN1_HUMAN	multimerin 1	894					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATCAGGCTCTTCAACTGCAAG	0.358000													7	402					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587621	36587621	+	Silent	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr22:36587621C>T	ENST00000332987.1	-	7	968	c.546G>A	c.(544-546)ggG>ggA	p.G182G	APOL4_ENST00000352371.1_Silent_p.G185G|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000429038.2_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	186					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						TGGAGGCGATCCCAGCCGTGG	0.552000													38	60					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77042773	77042773	+	Missense_Mutation	SNP	A	A	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:77042773A>G	ENST00000339142.2	+	4	847	c.292A>G	c.(292-294)Aaa>Gaa	p.K98E	C1QTNF1_ENST00000392445.2_Missense_Mutation_p.K98E|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.K16E|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.K98E|C1QTNF1_ENST00000578229.1_Missense_Mutation_p.K16E|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.K98E|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.K108E|C1QTNF1_ENST00000580474.1_Missense_Mutation_p.K98E|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.K98E|C1QTNF1_ENST00000580454.1_Missense_Mutation_p.K98E	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	98						collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			CACTATCTTGAAAGGTCAGAT	0.632000											OREG0024791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	419					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645603	167645603	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr5:167645603G>A	ENST00000519204.1	+	22	4462	c.4344G>A	c.(4342-4344)gcG>gcA	p.A1448A	TENM2_ENST00000403607.2_Silent_p.A1393A|TENM2_ENST00000518659.1_Silent_p.A1569A|TENM2_ENST00000520394.1_Silent_p.A1330A|TENM2_ENST00000545108.1_Silent_p.A1568A					teneurin transmembrane protein 2																		GGATCAGGGCGGTCAGCAAGA	0.493000													6	942					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810717	65810717	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:65810717G>A	ENST00000312006.4	-	3	838	c.557C>T	c.(556-558)gCg>gTg	p.A186V	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.A186V	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	186					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						TGCCTCGGGCGCGCGCAGGAA	0.677000													5	121					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518491	86518491	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:86518491C>T	ENST00000297814.2	-	4	1085	c.942G>A	c.(940-942)atG>atA	p.M314I	KIF27_ENST00000334204.2_Missense_Mutation_p.M314I|KIF27_ENST00000413982.1_Missense_Mutation_p.M314I	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	314					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						CACATGTGATCATGACAGTCT	0.448000													8	387					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123472826	123472826	+	Silent	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:123472826C>T	ENST00000280562.5	-	19	3139	c.2934G>A	c.(2932-2934)aaG>aaA	p.K978K	PITPNM2_ENST00000542749.1_Silent_p.K984K|PITPNM2_ENST00000320201.4_Silent_p.K984K|PITPNM2_ENST00000392428.1_Silent_p.K705K			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	0					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TCTCCCTTGGCTTTGAGGGGG	0.642000													28	826					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414398	20414398	+	Missense_Mutation	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:20414398C>G	ENST00000380338.4	-	5	732	c.446G>C	c.(445-447)aGc>aCc	p.S149T	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Missense_Mutation_p.S146T|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	149	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		gctgctgctgctgGTATGAAT	0.493000			T	MLL	ALL								6	339					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275283	114275283	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:114275283G>A	ENST00000357077.4	+	38	5562	c.5509G>A	c.(5509-5511)Gca>Aca	p.A1837T	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.A1804T|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1804	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.A1837T(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCCTCTTCCGCAAAAACTGA	0.507000													5	619					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120818809	120818809	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr10:120818809G>A	ENST00000369144.3	-	11	1671	c.1544C>T	c.(1543-1545)cCt>cTt	p.P515L	EIF3A_ENST00000478852.1_Intron|EIF3A_ENST00000541549.1_Missense_Mutation_p.P481L	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	515					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CTGCTCTGAAGGCATGCTTTG	0.443000													76	284					0	0	1	0	0
MEN1	0	broad.mit.edu	37	11	64574572	64574572	+	Splice_Site	SNP	T	T	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:64574572T>C	ENST00000337652.1	-	6	1343		c.e6-2		MEN1_ENST00000377326.3_Splice_Site|MEN1_ENST00000394376.1_Splice_Site|MEN1_ENST00000315422.4_Splice_Site|MEN1_ENST00000377321.1_Splice_Site|MEN1_ENST00000394374.2_Splice_Site|MEN1_ENST00000443283.1_Splice_Site|MEN1_ENST00000312049.6_Splice_Site|MEN1_ENST00000377316.2_Splice_Site|MEN1_ENST00000377313.1_Splice_Site	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I						DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						ATGGGGTACCTAGGAAAGGAT	0.622000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				78	13					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33588098	33588098	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:33588098G>A	ENST00000262873.7	+	37	5002	c.4910G>A	c.(4909-4911)cGc>cAc	p.R1637H		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1595						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCCCATAGGCGCAACCACCAG	0.582000													7	1218					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25671330	25671330	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:25671330C>T	ENST00000382051.3	+	7	747	c.697C>T	c.(697-699)Ccc>Tcc	p.P233S	SLC34A2_ENST00000504570.1_Missense_Mutation_p.P232S|SLC34A2_ENST00000503434.1_Missense_Mutation_p.P232S	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	233					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GGTGCTCTTGCCCGTGGAGGT	0.512000			T	ROS1	NSCLC								8	762					0	0	1	0	0
ORM1	5004	broad.mit.edu	37	9	117087391	117087391	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:117087391C>T	ENST00000259396.8	+	5	577	c.499C>T	c.(499-501)Cgc>Tgc	p.R167C	ORM1_ENST00000477456.1_3'UTR	NM_000607.2	NP_000598.2	P02763	A1AG1_HUMAN	orosomucoid 1	167			R -> C (in dbSNP:rs3182034).		acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	CGACTGCTTGCGCATTCCCAA	0.562000													5	399					0	0	1	0	0
CRNKL1	51340	broad.mit.edu	37	20	20018172	20018172	+	Missense_Mutation	SNP	T	T	C	rs111503447		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:20018172T>C	ENST00000377340.2	-	14	2205	c.2174A>G	c.(2173-2175)gAa>gGa	p.E725G	CRNKL1_ENST00000377327.4_Missense_Mutation_p.E713G|CRNKL1_ENST00000536226.1_Missense_Mutation_p.E564G|CRNKL1_ENST00000521379.1_5'UTR	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	725					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						CAAACTTCCTTCTTTTCCTGA	0.343000													212	224					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158262047	158262047	+	Missense_Mutation	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:158262047C>A	ENST00000368170.3	+	3	781	c.502C>A	c.(502-504)Cat>Aat	p.H168N		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	168					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					TCTACTCAATCATCAGTATGA	0.448000													6	826					3.59834e-05	3.83624e-05	1	1	0
CIT	11113	broad.mit.edu	37	12	120159148	120159148	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:120159148C>T	ENST00000392521.2	-	29	3753	c.3698G>A	c.(3697-3699)aGa>aAa	p.R1233K	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.R1191K	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1191	Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAAGTCACTTCTTTCTGTCTT	0.483000													5	286					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47676485	47676485	+	Missense_Mutation	SNP	A	A	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:47676485A>T	ENST00000273857.4	-	10	1281	c.1282T>A	c.(1282-1284)Tgc>Agc	p.C428S	CORIN_ENST00000508498.1_Missense_Mutation_p.C289S|CORIN_ENST00000504584.1_Missense_Mutation_p.C391S|CORIN_ENST00000502252.1_Missense_Mutation_p.C361S|CORIN_ENST00000505909.1_Missense_Mutation_p.C391S	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	428					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TTGTAGAGGCATCTTTGGTCT	0.428000													15	403					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123474421	123474421	+	Missense_Mutation	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:123474421T>G	ENST00000320201.4	-	17	2782	c.2644A>C	c.(2644-2646)Acc>Ccc	p.T882P	PITPNM2_ENST00000542749.1_Missense_Mutation_p.T882P|PITPNM2_ENST00000280562.5_Intron|PITPNM2_ENST00000392428.1_Missense_Mutation_p.T603P	NM_020845.2	NP_065896.1	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	882	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCAGGGGTGGTGGGGCTGGGG	0.687000													6	59					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63170286	63170286	+	Missense_Mutation	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr10:63170286G>T	ENST00000399298.3	-	6	1269	c.901C>A	c.(901-903)Ctc>Atc	p.L301I	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	301						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					AAGCGGTAGAGTTGCAACACC	0.517000													7	213					0.000157383	0.000165061	1	1	0
GCC1	79571	broad.mit.edu	37	7	127222454	127222454	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:127222454C>T	ENST00000321407.2	-	2	2366	c.1942G>A	c.(1942-1944)Gcc>Acc	p.A648T		NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	648						Golgi membrane|plasma membrane	protein binding			breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GGCTCATTGGCCGCTGCAAGT	0.582000													7	502					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9887463	9887463	+	Silent	SNP	C	C	T	rs111251988		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr18:9887463C>T	ENST00000306084.6	+	2	1186	c.987C>T	c.(985-987)atC>atT	p.I329I	TXNDC2_ENST00000536353.2_3'UTR|TXNDC2_ENST00000357775.4_Silent_p.I262I	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	329	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGGGTGACATCCCCAAGTCCC	0.592000													5	400					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123474427	123474427	+	Missense_Mutation	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:123474427T>G	ENST00000320201.4	-	17	2776	c.2638A>C	c.(2638-2640)Agc>Cgc	p.S880R	PITPNM2_ENST00000542749.1_Missense_Mutation_p.S880R|PITPNM2_ENST00000280562.5_Intron|PITPNM2_ENST00000392428.1_Missense_Mutation_p.S601R	NM_020845.2	NP_065896.1	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	880	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GTGGTGGGGCTGGGGGCGGGC	0.687000													6	36					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								12	320					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130411066	130411066	+	Missense_Mutation	SNP	A	A	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:130411066A>G	ENST00000370904.1	-	20	3338	c.2428T>C	c.(2428-2430)Tcc>Ccc	p.S810P	IGSF1_ENST00000370903.3_Missense_Mutation_p.S824P|IGSF1_ENST00000370910.1_Missense_Mutation_p.S810P|IGSF1_ENST00000361420.3_Missense_Mutation_p.S819P|IGSF1_ENST00000467244.1_5'UTR			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	819	Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						CTGTCACTGGATGCTATTTCA	0.517000													6	817					0	0	1	0	0
GEMIN2	8487	broad.mit.edu	37	14	39597482	39597482	+	Splice_Site	SNP	A	A	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr14:39597482A>T	ENST00000308317.6	+	7	647		c.e7-1		GEMIN2_ENST00000396249.2_Splice_Site|GEMIN2_ENST00000250379.8_Splice_Site	NM_003616.2	NP_003607.1	O14893	GEMI2_HUMAN	gem (nuclear organelle) associated protein 2						ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding										TTTTTTTTTTAGGCAACAGTA	0.308000													9	344					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24483551	24483551	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr22:24483551G>A	ENST00000398319.2	+	23	3795	c.3410G>A	c.(3409-3411)aGc>aAc	p.S1137N	CABIN1_ENST00000263119.5_Missense_Mutation_p.S1137N|CABIN1_ENST00000405822.2_Missense_Mutation_p.S1087N	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1137					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GAGATTGACAGCTCCAACTTG	0.552000													4	223					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65309380	65309380	+	Silent	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr5:65309380C>A	ENST00000284037.5	+	6	779	c.390C>A	c.(388-390)ctC>ctA	p.L130L	ERBB2IP_ENST00000416865.2_Silent_p.L130L|ERBB2IP_ENST00000380943.2_Silent_p.L130L|ERBB2IP_ENST00000511297.1_Silent_p.L130L|ERBB2IP_ENST00000380938.2_Silent_p.L130L|ERBB2IP_ENST00000380936.1_Silent_p.L130L|ERBB2IP_ENST00000508515.1_Silent_p.L130L|ERBB2IP_ENST00000380935.1_Silent_p.L130L|ERBB2IP_ENST00000380939.2_Silent_p.L130L|ERBB2IP_ENST00000506030.1_Silent_p.L130L	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	130					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TATGTAGGCTCCCTGATGGAT	0.338000													121	541					1.75003e-54	1.99782e-54	1	1	0
PVRL1	5818	broad.mit.edu	37	11	119535743	119535743	+	Missense_Mutation	SNP	T	T	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:119535743T>C	ENST00000264025.3	-	6	1798	c.1268A>G	c.(1267-1269)gAc>gGc	p.D423G	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	423					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CTTCTCGTCGTCTGAGTCGTC	0.652000													8	180					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35095163	35095163	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:35095163G>A	ENST00000378617.3	-	2	794	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	PIGO_ENST00000298004.5_Missense_Mutation_p.R134C|PIGO_ENST00000492770.1_5'UTR|PIGO_ENST00000361778.2_Missense_Mutation_p.R134C|PIGO_ENST00000341666.3_Missense_Mutation_p.R134C	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	134					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCCTTGAGGCGCTGCATGGTG	0.557000													5	437					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664364	124664364	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr8:124664364G>A	ENST00000325995.7	-	1	826	c.803C>T	c.(802-804)cCa>cTa	p.P268L	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	268								p.P268Q(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						TTTGCAGTCTGGGACGGTGGT	0.552000													7	216					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85969720	85969720	+	Missense_Mutation	SNP	A	A	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:85969720A>G	ENST00000373131.1	+	5	1225	c.1062A>G	c.(1060-1062)atA>atG	p.I354M	DACH2_ENST00000373125.4_Missense_Mutation_p.I367M|DACH2_ENST00000510272.1_Missense_Mutation_p.I148M|DACH2_ENST00000508860.1_Missense_Mutation_p.I200M	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						CCTCTGTTATAAAGGTAAGAA	0.398000													34	208					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769153	50769153	+	Missense_Mutation	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:50769153C>G	ENST00000216923.4	-	6	1927	c.1578G>C	c.(1576-1578)ttG>ttC	p.L526F	ZFP64_ENST00000371515.4_Missense_Mutation_p.L524F|ZFP64_ENST00000346617.4_Missense_Mutation_p.L472F|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000361387.2_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TCTGGGCCACCAAGGCAGGCG	0.652000													7	171					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56688700	56688700	+	Splice_Site	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:56688700G>A	ENST00000389934.3	-	10	1123	c.1005_splice	c.e10-1	p.R336_splice	TEX14_ENST00000349033.5_Splice_Site_p.R336_splice|TEX14_ENST00000240361.8_Splice_Site_p.R342_splice	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	342	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACTGGGACCGCTGCAAGCAA	0.498000													5	351					0	0	1	0	0
AC005562.1	0	broad.mit.edu	37	17	28961033	28961033	+	RNA	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:28961033T>G	ENST00000417404.1	+	0	1291				LRRC37BP1_ENST00000412831.1_RNA|SMURF2P1_ENST00000578265.1_RNA																							AGTTCCAGGATATGACTATAA	0.264000													4	122					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35090130	35090130	+	Missense_Mutation	SNP	G	G	A	rs149391665	by1000genomes	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:35090130G>A	ENST00000378617.3	-	9	3396	c.3002C>T	c.(3001-3003)gCg>gTg	p.A1001V	PIGO_ENST00000298004.5_Missense_Mutation_p.A584V|PIGO_ENST00000361778.2_Missense_Mutation_p.A584V|PIGO_ENST00000341666.3_Missense_Mutation_p.A1001V	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	1001					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTGCTGAGGCGCATCCCGGAG	0.582000													5	459					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55994105	55994105	+	Silent	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:55994105C>T	ENST00000391718.2	+	3	2098	c.1533C>T	c.(1531-1533)tgC>tgT	p.C511C	ZNF628_ENST00000598519.1_Silent_p.C515C			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	511						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		GTGGCCAGTGCGGCCTCACCT	0.682000													5	337					0	0	1	0	0
MEPCE	56257	broad.mit.edu	37	7	100028427	100028427	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:100028427G>A	ENST00000310512.2	+	1	1174	c.786G>A	c.(784-786)cgG>cgA	p.R262R	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	262							methyltransferase activity	p.R262R(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTCGGAAGCGGCATAGACACC	0.597000													8	1083					0	0	1	0	0
RPRD1A	55197	broad.mit.edu	37	18	33573139	33573139	+	Missense_Mutation	SNP	G	G	A	rs142715408		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr18:33573139G>A	ENST00000399022.4	-	7	1085	c.914C>T	c.(913-915)gCg>gTg	p.A305V	RPRD1A_ENST00000357384.4_Missense_Mutation_p.A305V|RPRD1A_ENST00000588737.1_Missense_Mutation_p.A269V|RPRD1A_ENST00000590898.1_Missense_Mutation_p.A269V|RPRD1A_ENST00000337059.5_Missense_Mutation_p.A269V	NM_018170.3	NP_060640.2	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing 1A	305										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(2)	12						GATGTCTCCCGCAAAGGGCAG	0.532000													5	324					0	0	1	0	0
TSIX	0	broad.mit.edu	37	X	73046100	73046100	+	RNA	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:73046100G>A	ENST00000604411.1	+	0	34061				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CCAACAACCTGACCATTTTAT	0.413000													15	367					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87921837	87921837	+	Missense_Mutation	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr16:87921837T>G	ENST00000309893.2	-	7	881	c.816A>C	c.(814-816)gaA>gaC	p.E272D		NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	272					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		TCTTCTCCTCTTCACCAAGTG	0.542000													58	8					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111688612	111688612	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr3:111688612C>T	ENST00000431670.2	+	16	3802	c.3391C>T	c.(3391-3393)Cac>Tac	p.H1131Y	PHLDB2_ENST00000393925.3_Missense_Mutation_p.H1131Y|PHLDB2_ENST00000393923.3_Missense_Mutation_p.H1115Y|PHLDB2_ENST00000495180.1_Missense_Mutation_p.H622Y|PHLDB2_ENST00000481953.1_Missense_Mutation_p.H1088Y|PHLDB2_ENST00000412622.1_Missense_Mutation_p.H1088Y	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1131						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GACTGCTGGCCACAATATTGA	0.468000													26	221					0	0	1	0	0
GSX1	219409	broad.mit.edu	37	13	28367938	28367938	+	Silent	SNP	C	C	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr13:28367938C>G	ENST00000302945.2	+	2	696	c.648C>G	c.(646-648)ggC>ggG	p.G216G		NM_145657.1	NP_663632.1	Q9H4S2	GSX1_HUMAN	GS homeobox 1	216	Poly-Gly.				positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)	4		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		gcggcggcggcgggggtgccg	0.627000													5	272					0	0	1	0	0
TOM1L1	10040	broad.mit.edu	37	17	53007467	53007467	+	Missense_Mutation	SNP	A	A	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:53007467A>T	ENST00000575882.1	+	8	1107	c.754A>T	c.(754-756)Agg>Tgg	p.R252W	TOM1L1_ENST00000445275.2_Missense_Mutation_p.R252W|TOM1L1_ENST00000570371.1_Missense_Mutation_p.R252W|TOM1L1_ENST00000536554.1_Missense_Mutation_p.R175W|TOM1L1_ENST00000575333.1_Missense_Mutation_p.R252W|TOM1L1_ENST00000540336.1_Missense_Mutation_p.R140W|TOM1L1_ENST00000572158.1_Missense_Mutation_p.R245W|TOM1L1_ENST00000348161.4_Missense_Mutation_p.R175W	NM_005486.2	NP_005477.2	O75674	TM1L1_HUMAN	target of myb1 (chicken)-like 1	252	GAT.				intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	15						GATGCAGGAGAGGATCATGGA	0.418000													11	419					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661478	22661478	+	RNA	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr22:22661478T>G	ENST00000426066.1	+	0	368					NR_027293.1																						CAGATGCGTCTGAAGAAACAT	0.488000													12	167					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38750805	38750805	+	Missense_Mutation	SNP	C	C	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr6:38750805C>A	ENST00000359357.3	+	15	1888	c.1634C>A	c.(1633-1635)cCg>cAg	p.P545Q	DNAH8_ENST00000441566.1_Missense_Mutation_p.P545Q|DNAH8_ENST00000449981.2_Missense_Mutation_p.P762Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTATCAAGTCCGGACGGTAAA	0.368000													107	16					2.18931e-77	2.56746e-77	1	1	0
GANAB	23193	broad.mit.edu	37	11	62406863	62406863	+	Missense_Mutation	SNP	G	G	A	rs143393884	byFrequency	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:62406863G>A	ENST00000346178.4	-	3	235	c.220C>T	c.(220-222)Ctc>Ttc	p.L74F	GANAB_ENST00000534779.1_Intron|GANAB_ENST00000540933.1_Intron|GANAB_ENST00000356638.3_Missense_Mutation_p.L74F|GANAB_ENST00000534422.1_5'UTR	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	74					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						TGGACCGTGAGGGAATCAGGA	0.567000													54	181					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80646047	80646047	+	Silent	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:80646047G>A	ENST00000286548.4	-	1	327	c.105C>T	c.(103-105)gaC>gaT	p.D35D		NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	35					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						CCCGGCGGGCGTCCCGCTTGT	0.716000			Mis		uveal melanoma								3	51					0	0	1	0	0
FBXO21	23014	broad.mit.edu	37	12	117595774	117595774	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:117595774C>T	ENST00000427718.2	-	10	1495	c.1421G>A	c.(1420-1422)cGc>cAc	p.R474H	FBXO21_ENST00000330622.5_Missense_Mutation_p.R481H	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	481					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CTCCTTTTTGCGCTCAATGTG	0.562000													8	1191					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11943564	11943564	+	Missense_Mutation	SNP	G	G	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:11943564G>A	ENST00000304060.5	+	4	1737	c.1573G>A	c.(1573-1575)Gag>Aag	p.E525K		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AAAGCCTTCAGAGCTGTGTCA	0.463000													5	322					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654450	38654450	+	RNA	SNP	T	T	G			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr10:38654450T>G	ENST00000494540.1	+	0	617					NR_003086.1																						AAATCTAATTTCAGCCTCGAG	0.478000													4	130					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7972131	7972131	+	Missense_Mutation	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:7972131G>T	ENST00000543909.1	-	14	1846	c.1087C>A	c.(1087-1089)Ctt>Att	p.L363I	SLC2A14_ENST00000542505.1_Missense_Mutation_p.L4I|SLC2A14_ENST00000396589.2_Missense_Mutation_p.L363I|SLC2A14_ENST00000539924.1_Missense_Mutation_p.L378I|SLC2A14_ENST00000340749.5_Missense_Mutation_p.L340I|SLC2A14_ENST00000431042.2_Missense_Mutation_p.L340I|SLC2A14_ENST00000542546.1_Missense_Mutation_p.L254I|SLC2A14_ENST00000535295.1_Missense_Mutation_p.L254I			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	363					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		ATCCCTCCAAGGCCTATCATA	0.428000													6	480					5.18039e-06	5.61572e-06	1	1	0
CDC42BPG	55561	broad.mit.edu	37	11	64595223	64595223	+	Missense_Mutation	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr11:64595223C>T	ENST00000342711.5	-	31	3999	c.4000G>A	c.(4000-4002)Gag>Aag	p.E1334K		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1334	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						ATGGAGTTCTCGCTGAACACT	0.637000													51	80					0	0	1	0	0
FKBP14	55033	broad.mit.edu	37	7	30066109	30066109	+	Missense_Mutation	SNP	A	A	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:30066109A>C	ENST00000222803.5	-	1	191	c.16T>G	c.(16-18)Tgg>Ggg	p.W6G		NM_017946.3	NP_060416.1	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14, 22 kDa	6					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|large_intestine(2)|lung(2)	5						ACCGCGTTCCACAAGAAAAGC	0.448000													9	305					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													6	235					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110087200	110087200	+	Missense_Mutation	SNP	G	G	C			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:110087200G>C	ENST00000358015.3	+	9	1382	c.1031G>C	c.(1030-1032)gGt>gCt	p.G344A	RAD23B_ENST00000416373.2_Missense_Mutation_p.G272A	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	344	Poly-Gly.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						GGAGGTGGAGGTGGCAGTGGA	0.423000								Direct reversal of damage;Nucleotide excision repair (NER)					4	333					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029070	37029070	+	Missense_Mutation	SNP	G	G	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:37029070G>T	ENST00000358047.3	+	1	2639	c.2587G>T	c.(2587-2589)Gtt>Ttt	p.V863F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	863										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGACCTAGGAGTTAATGAAGA	0.458000													6	357					0.0293803	0.0296099	1	1	0
SPEN	23013	broad.mit.edu	37	1	16257931	16257937	+	Frame_Shift_Del	DEL	TGCCAAG	TGCCAAG	-	rs142022144		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:16257931_16257937delTGCCAAG	ENST00000375759.3	+	11	5400_5406	c.5196_5202delTGCCAAG	c.(5194-5202)gafs	p.DAK1732fs		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1732					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTTATCTGGATGCCAAGCCTCCAACTC	0.570													103	645	---	---	---	---					
AMPD1	270	broad.mit.edu	37	1	115216566	115216585	+	Frame_Shift_Del	DEL	CAGTGAGATCATTAGCCCTT	CAGTGAGATCATTAGCCCTT	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr1:115216566_115216585delCAGTGAGATCATTAGCCCTT	ENST00000369538.3	-	13	2053_2072	c.2006_2025delAAGGGCTAATGATCTCACTG	c.(2005-2025)afs	p.KGLMISL669fs	AMPD1_ENST00000353928.6_Frame_Shift_Del_p.KGLMISL640fs|AMPD1_ENST00000520113.2_Frame_Shift_Del_p.KGLMISL673fs	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	640					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding	p.G674W(1)|p.K673N(1)|p.K640N(1)|p.G641W(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CATCTGTAGACAGTGAGATCATTAGCCCTTTCTGAAGGAA	0.395													47	32	---	---	---	---					
ANKRD36BP2	0	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													8	14	---	---	---	---					
LINC00971	0	broad.mit.edu	37	3	84741480	84741480	+	RNA	DEL	A	A	-	rs140144338		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr3:84741480delA	ENST00000484892.1	-	0	2354					NR_033860.1																						CCTGTCCCAGAAAAAAAAAAA	0.388													6	8	---	---	---	---					
TLR1	7096	broad.mit.edu	37	4	38798148	38798148	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:38798148delA	ENST00000308979.2	-	4	2578	c.2305delT	c.(2305-2307)ggfs	p.W769fs	TLR1_ENST00000502213.2_Frame_Shift_Del_p.W769fs	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	769	TIR.				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						AAGTTAGCCCAAAAAAGGCCA	0.418													7	450	---	---	---	---					
C4orf22	255119	broad.mit.edu	37	4	81791254	81791254	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:81791254delA	ENST00000358105.3	+	4	490	c.441delA	c.(439-441)ggfs	p.G147fs	C4orf22_ENST00000508675.1_Frame_Shift_Del_p.G164fs	NM_152770.2	NP_689983.2	Q6V702	CD022_HUMAN	chromosome 4 open reading frame 22	147										NS(1)|large_intestine(3)|lung(5)|prostate(1)|skin(5)	15						ACTTTACTGGAAAAAAAAGAC	0.373													7	588	---	---	---	---					
CXXC4	80319	broad.mit.edu	37	4	105412094	105412096	+	In_Frame_Del	DEL	GAG	GAG	-	rs146939312		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr4:105412094_105412096delGAG	ENST00000394767.2	-	2	1314_1316	c.864_866delCTC	c.(862-867)tcg>tc	p.SS290del	AC093628.1_ENST00000606234.1_RNA|CXXC4_ENST00000466963.1_Intron|CXXC4_ENST00000426831.1_In_Frame_Del_p.SS121del	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	121					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding	p.S120A(1)		kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGAGGAGGACGAGGAGGAGGAGG	0.606													7	486	---	---	---	---					
ZSCAN16	80345	broad.mit.edu	37	6	28097476	28097480	+	Frame_Shift_Del	DEL	ATGTG	ATGTG	-	rs143274731		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr6:28097476_28097480delATGTG	ENST00000340487.4	+	4	944_948	c.795_799delATGTG	c.(793-801)aaatfs	p.KCD265fs	RP1-265C24.9_ENST00000602810.1_RNA|RP1-265C24.9_ENST00000600652.1_RNA	NM_025231.1	NP_079507.1	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	265					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|liver(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						AGCCCTATAAATGTGATGAGTGTGG	0.405													139	48	---	---	---	---					
PMS2CL	0	broad.mit.edu	37	7	6771663	6771664	+	RNA	INS	-	-	T			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:6771663_6771664insT	ENST00000486256.1	+	0	619					NR_002217.1																						AGGATTCCTACttttttttttc	0.416													8	239	---	---	---	---					
MPP6	51678	broad.mit.edu	37	7	24705666	24705666	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:24705666delA	ENST00000396475.2	+	9	1209	c.910delA	c.(910-912)aafs	p.K308fs	MPP6_ENST00000409761.1_Frame_Shift_Del_p.K196fs|MPP6_ENST00000222644.4_Frame_Shift_Del_p.K308fs	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	308					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						TATAAGTAGCAAAAAAAAGAA	0.299													9	832	---	---	---	---					
WNT2	7472	broad.mit.edu	37	7	116955171	116955175	+	Frame_Shift_Del	DEL	TCCTT	TCCTT	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr7:116955171_116955175delTCCTT	ENST00000265441.3	-	3	837_841	c.538_542delAAGGA	c.(538-543)tfs	p.KD180fs	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	180					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GGCTCTGGCAtcctttcctttcctt	0.463													7	659	---	---	---	---					
TMEM38B	55151	broad.mit.edu	37	9	108456999	108456999	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:108456999delT	ENST00000374692.3	+	1	175	c.58delT	c.(58-60)ttfs	p.F21fs		NM_018112.1	NP_060582.1	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	21						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						CATGTTTCCCTTTTTTGACAT	0.627													7	712	---	---	---	---					
RABL6	55684	broad.mit.edu	37	9	139734633	139734635	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr9:139734633_139734635delAGA	ENST00000371675.3	+	14	2498_2500	c.1613_1615delAGA	c.(1612-1617)gag>g	p.EK538del	RABL6_ENST00000371663.4_In_Frame_Del_p.EK654del|RABL6_ENST00000357466.2_Intron|RABL6_ENST00000432842.2_3'UTR|RABL6_ENST00000311502.7_In_Frame_Del_p.EK653del					RAB, member RAS oncogene family-like 6																		CCCTCTaaggagaagaagaagaa	0.571													8	281	---	---	---	---					
ACSM4	341392	broad.mit.edu	37	12	7456935	7456935	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:7456935delT	ENST00000399422.4	+	1	56	c.8delT	c.(7-9)atfs	p.I3fs		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	3					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						ACCATGAAGATTTTTTTCCGC	0.473													8	899	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546056	11546056	+	Frame_Shift_Del	DEL	G	G	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:11546056delG	ENST00000389362.4	-	3	991	c.956delC	c.(955-957)cafs	p.P322fs	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGAGGAGGTGGGGGACCTTG	0.612													7	871	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57605740	57605742	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:57605740_57605742delTGC	ENST00000243077.3	+	87	13755_13757	c.13289_13291delTGC	c.(13288-13293)ttg>t	p.LL4432del		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4432					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTCTGCTGTTGCTGCTGCTGCT	0.557													8	687	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													7	1226	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr12:133220099_133220100delCA	ENST00000320574.5	-	34	4380_4381	c.4337_4338delTG	c.(4336-4338)gfs	p.V1447fs	POLE_ENST00000535270.1_Frame_Shift_Del_p.V1420fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1447					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					22	1308	---	---	---	---					
ZMYM5	9205	broad.mit.edu	37	13	20426143	20426145	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr13:20426143_20426145delCAT	ENST00000337963.4	-	3	440_442	c.176_178delATG	c.(175-180)gtt>g	p.DV59del	ZMYM5_ENST00000382907.4_In_Frame_Del_p.DV59del|ZMYM5_ENST00000382905.4_In_Frame_Del_p.DV59del	NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	59	Poly-Asp.					nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		ATAAACACAAcatcatcatcatc	0.379													11	431	---	---	---	---					
LIG4	3981	broad.mit.edu	37	13	108861737	108861737	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr13:108861737delT	ENST00000356922.4	-	2	2152	c.1880delA	c.(1879-1881)agfs	p.K627fs	LIG4_ENST00000442234.1_Frame_Shift_Del_p.K627fs|LIG4_ENST00000405925.1_Frame_Shift_Del_p.K627fs	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	627					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AGCTTTCCGCTTTTTTTCTTG	0.383								Non-homologous end-joining					8	497	---	---	---	---					
HSP90AA1	3320	broad.mit.edu	37	14	102551161	102551163	+	In_Frame_Del	DEL	TCT	TCT	-	rs55793809	byFrequency	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr14:102551161_102551163delTCT	ENST00000334701.7	-	6	1483_1485	c.1202_1204delAGA	c.(1201-1206)att>a	p.KI401del	HSP90AA1_ENST00000441629.2_In_Frame_Del_p.KI100del|HSP90AA1_ENST00000216281.8_In_Frame_Del_p.KI279del	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	279					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ttttccttaatcttcttcttctt	0.389													11	299	---	---	---	---					
SLC6A10P	0	broad.mit.edu	37	16	32896136	32896137	+	RNA	DEL	TG	TG	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr16:32896136_32896137delTG	ENST00000330048.5	-	0	233					NR_003083.2																						agtggCCCATtgtgtgtgtgtg	0.678													3	4	---	---	---	---					
TUBB8P7	0	broad.mit.edu	37	16	90161966	90161966	+	RNA	DEL	T	T	-	rs56265310		TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr16:90161966delT	ENST00000564451.1	+	0	1319				TUBB8P7_ENST00000567960.1_RNA																							CTACCATGAGTTGGGGTCACC	0.542													6	10	---	---	---	---					
TOB1	10140	broad.mit.edu	37	17	48940610	48940612	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:48940610_48940612delGTG	ENST00000499247.2	-	2	1200_1202	c.767_769delCAC	c.(766-771)cag>c	p.PQ256del	TOB1_ENST00000268957.3_In_Frame_Del_p.PQ256del	NM_001243885.1|NM_005749.3	NP_001230814.1|NP_005740.1	P50616	TOB1_HUMAN	transducer of ERBB2, 1	256	Poly-Pro.				negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			tgttgctgctgtggtggtggtgg	0.517													7	199	---	---	---	---					
AC079210.1	0	broad.mit.edu	37	17	66539865	66539868	+	Frame_Shift_Del	DEL	GGAA	GGAA	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:66539865_66539868delGGAA	ENST00000600820.1	+	1	497_500	c.124_127delGGAA	c.(124-129)ggfs	p.GR42fs	PRKAR1A_ENST00000588188.2_Intron|FAM20A_ENST00000592554.1_Intron|FAM20A_ENST00000226094.5_Intron																							GCTGCTGTCTGGAAGGAAGGAAGG	0.510													7	321	---	---	---	---					
SRP68	6730	broad.mit.edu	37	17	74068528	74068530	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr17:74068528_74068530delGCC	ENST00000307877.2	-	1	204_206	c.43_45delGGC	c.(43-45)del	p.G15del	SRP68_ENST00000539137.1_In_Frame_Del_p.G15del|SRP68_ENST00000355113.5_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	15	Poly-Gly.			Missing (in Ref. 1).	response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						cgccgccactgccgccgccgccg	0.709													9	483	---	---	---	---					
TGIF1	7050	broad.mit.edu	37	18	3452222	3452223	+	Frame_Shift_Del	DEL	CT	CT	-	rs11571510	by1000genomes	TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr18:3452222_3452223delCT	ENST00000330513.5	+	1	548_549	c.245_246delCT	c.(244-246)cfs	p.P85fs	TGIF1_ENST00000401449.1_Intron|TGIF1_ENST00000551402.1_Intron|TGIF1_ENST00000345133.5_Intron|TGIF1_ENST00000405385.3_Intron|TGIF1_ENST00000343820.5_Intron|TGIF1_ENST00000577543.1_Intron|TGIF1_ENST00000551541.1_Intron|TGIF1_ENST00000548489.2_Intron|TGIF1_ENST00000407501.2_Intron	NM_170695.2	NP_733796.2	Q15583	TGIF1_HUMAN	TGFB-induced factor homeobox 1	85					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.P83fs*51(1)		cervix(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				TGCGCCCCCCCTCCTCCACCGG	0.762													7	147	---	---	---	---					
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr19:38882864_38882866delCCT	ENST00000587013.1	+	3	569_571	c.491_493delCCT	c.(490-495)ccc>c	p.PS164del	SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000338502.4_In_Frame_Del_p.PS120del|SPRED3_ENST00000586301.1_In_Frame_Del_p.PS120del			Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	120					multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.645													7	105	---	---	---	---					
LPIN3	64900	broad.mit.edu	37	20	39981287	39981287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr20:39981287delA	ENST00000373257.3	+	10	1496	c.1405delA	c.(1405-1407)aafs	p.K469fs		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	469					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GGACCTCACCAAAAACCCCGG	0.562													7	1435	---	---	---	---					
ANKRD20A11P	0	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													10	313	---	---	---	---					
PAK3	5063	broad.mit.edu	37	X	110406206	110406208	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:110406206_110406208delGAA	ENST00000519681.1	+	10	1037_1039	c.595_597delGAA	c.(595-597)del	p.E203del	PAK3_ENST00000518291.1_In_Frame_Del_p.E218del|PAK3_ENST00000446737.1_In_Frame_Del_p.E182del|PAK3_ENST00000372007.4_In_Frame_Del_p.E182del|PAK3_ENST00000425146.1_In_Frame_Del_p.E182del|PAK3_ENST00000262836.4_In_Frame_Del_p.E197del|PAK3_ENST00000372010.1_In_Frame_Del_p.E197del|PAK3_ENST00000360648.4_In_Frame_Del_p.E218del|PAK3_ENST00000417227.1_In_Frame_Del_p.E203del			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						agatgaagaggaagaagaagaag	0.394										TSP Lung(19;0.15)			8	389	---	---	---	---					
CUL4B	8450	broad.mit.edu	37	X	119694117	119694119	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:119694117_119694119delGAG	ENST00000371322.5	-	1	436_438	c.375_377delCTC	c.(373-378)tca>tc	p.SS127del	CUL4B_ENST00000404115.3_In_Frame_Del_p.SS145del|CUL4B_ENST00000336592.6_In_Frame_Del_p.SS132del	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	145	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TGGTGAAGATgaggaggaggagg	0.488													7	224	---	---	---	---					
HTATSF1	27336	broad.mit.edu	37	X	135585048	135585050	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-2L-AAQM-01A-11D-A397-08	TCGA-2L-AAQM-11A-11D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9c95f04-6d9d-45bd-b94a-1c497a4107b3	8b8b0bf9-463b-4df5-9bb1-7d94a9dc5565	g.chrX:135585048_135585050delAAG	ENST00000535601.1	+	6	1104_1106	c.682_684delAAG	c.(682-684)del	p.K232del	HTATSF1_ENST00000218364.4_In_Frame_Del_p.K232del	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	232	Poly-Lys.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TGATGCCTCAAAGAAGAAGAAGA	0.335													7	312	---	---	---	---