Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
FAM13C	220965	broad.mit.edu	37	10	61028449	61028449	+	Missense_Mutation	SNP	G	G	A	rs138913406	byFrequency	TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr10:61028449G>A	ENST00000373868.2	-	8	893	c.806C>T	c.(805-807)cCg>cTg	p.P269L	FAM13C_ENST00000442566.3_Missense_Mutation_p.P290L|FAM13C_ENST00000373867.3_Missense_Mutation_p.P186L|FAM13C_ENST00000435852.2_Missense_Mutation_p.P269L|FAM13C_ENST00000419214.2_Missense_Mutation_p.P269L|FAM13C_ENST00000277705.6_Missense_Mutation_p.P290L|FAM13C_ENST00000468840.2_Missense_Mutation_p.P186L|FAM13C_ENST00000422313.2_Missense_Mutation_p.P269L	NM_198215.3	NP_937858.2	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C			45					AGAACTCCGCGGCCTGCAGTG	0.493000																								0							SO:0001583	missense			ENST00000373868.2	1	1	hg19	CCDS7255.1	1	4.578754578754579E-4	1	0.0020325203252032522	0	0.0	0	0.0	0	0.0	G	14.53	2.563159	0.45694	0.001589	0.0	ENSG00000148541	ENST00000373867;ENST00000373868;ENST00000442566;ENST00000277705;ENST00000419214;ENST00000468840;ENST00000435852;ENST00000422313;ENST00000468696	T;T;T;T;T;T;T;T;T	0.75704	-0.96;-0.96;-0.96;-0.96;0.9;-0.96;-0.96;-0.96;-0.96	6.04	6.04	0.98038	.	0.142017	0.49916	N	0.000133	T	0.77618	0.4157	L	0.39147	1.195	0.80722	D	1	P;B;B;D;B	0.67145	0.487;0.018;0.296;0.996;0.347	B;B;B;P;B	0.53861	0.13;0.018;0.087;0.736;0.083	T	0.72347	-0.4321	10	0.27082	T	0.32	-3.6719	20.5891	0.99427	0.0:0.0:1.0:0.0	.	269;186;269;269;269	B7Z2K3;B7ZB77;Q8NE31-2;Q8NE31-3;Q8NE31	.;.;.;.;FA13C_HUMAN	L	186;269;290;290;269;186;269;269;47	ENSP00000362974:P186L;ENSP00000362975:P269L;ENSP00000395661:P290L;ENSP00000277705:P290L;ENSP00000391993:P269L;ENSP00000423896:P186L;ENSP00000392302:P269L;ENSP00000400241:P269L;ENSP00000445068:P47L	ENSP00000277705:P290L	P	-	2	0	FAM13C	60698455	1.000000	0.71417	1.000000	0.80357	0.406000	0.30931	3.913000	0.56394	2.876000	0.98609	0.650000	0.86243	CCG		TCGA-Q3-AA2A-01A-11D-A377-08	FAM13C-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000048162.2	1	0	1	50	181	0	55	0	1.239826e-01	0	3	0	55	2		0	0	0	0	0	2	1	1.000000	48	180	0	55	2		0	0	0	0	55	2	-3.442381	1	1	121398	43	45	1	1	2	3	2.055323	0	0.540000	1.930000	0.541239	0.800000	6.100000e-01	1.000000	0.800000	0.808416	0.800000	0	7.000000e-01	0.910000
PPP1R3C	5507	broad.mit.edu	37	10	93389892	93389892	+	Missense_Mutation	SNP	T	T	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr10:93389892T>C	ENST00000238994.5	-	2	830	c.746A>G	c.(745-747)aAt>aGt	p.N249S		NM_005398.5	NP_005389.1			protein phosphatase 1, regulatory subunit 3C			12		Colorectal(252;0.235)			CTGACCATCATTGTTGTCCCA	0.453000																								0							SO:0001583	missense			ENST00000238994.5	1	1	hg19	CCDS7416.1	.	.	.	.	.	.	.	.	.	.	T	16.97	3.270056	0.59540	.	.	ENSG00000119938	ENST00000238994;ENST00000438999;ENST00000500094	T	0.76316	-1.01	5.73	3.31	0.37934	Putative phosphatase regulatory subunit (2);	0.049016	0.85682	D	0.000000	D	0.90689	0.7079	H	0.97491	4.015	0.58432	D	0.999997	D	0.89917	1.0	D	0.85130	0.997	D	0.90361	0.4373	10	0.87932	D	0	-21.2088	8.006	0.30325	0.121:0.0672:0.0:0.8117	.	249	Q9UQK1	PPR3C_HUMAN	S	249;229;131	ENSP00000238994:N249S	ENSP00000238994:N249S	N	-	2	0	PPP1R3C	93379872	1.000000	0.71417	0.882000	0.34594	0.884000	0.51177	6.240000	0.72363	0.954000	0.37851	0.533000	0.62120	AAT		TCGA-Q3-AA2A-01A-11D-A377-08	PPP1R3C-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000049372.1	1	0	1	119	322	0	83	0	1.802628e-01	0	3	0	83	2		0	0	0	0	0	2	1	1.000000	119	320	0	83	2		0	0	0	0	83	2	-20.000000	1	1	121412	2	39	1	1	2	3	2.055323	0	0.540000	1.930000	0.541239	0.990000	8.400000e-01	1.000000	1.000000	0.970667	0.990000	1	9.200000e-01	1.000000
OR8I2	120586	broad.mit.edu	37	11	55861306	55861306	+	Missense_Mutation	SNP	C	C	A	rs148514357	by1000genomes	TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr11:55861306C>A	ENST00000302124.2	+	1	554	c.523C>A	c.(523-525)Cat>Aat	p.H175N		NM_001003750.1	NP_001003750.1	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2			53	Esophageal squamous(21;0.00693)				CAGCATCAATCATTTTTTTTG	0.443000																								0							SO:0001583	missense			ENST00000302124.2	1	0	hg19	CCDS31517.1	.	.	.	.	.	.	.	.	.	.	C	15.39	2.820045	0.50633	.	.	ENSG00000172154	ENST00000302124	T	0.00164	8.64	4.33	4.33	0.51752	GPCR, rhodopsin-like superfamily (1);	0.000000	0.41605	U	0.000848	T	0.00300	0.0009	M	0.84156	2.68	0.34928	D	0.74909	B	0.30634	0.288	B	0.35688	0.208	T	0.60831	-0.7185	10	0.72032	D	0.01	-15.4428	16.2092	0.82147	0.0:1.0:0.0:0.0	.	175	Q8N0Y5	OR8I2_HUMAN	N	175	ENSP00000303864:H175N	ENSP00000303864:H175N	H	+	1	0	OR8I2	55617882	0.998000	0.40836	0.998000	0.56505	0.285000	0.27093	2.855000	0.48333	2.115000	0.64714	0.440000	0.28878	CAT		TCGA-Q3-AA2A-01A-11D-A377-08	OR8I2-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding		1	0	0	28	523	0	121		0	0	0	0	121	2		0	0	0	0	0	2	1	1.000000	27	514	0	120	2		0	0	0	0	121	2	-2.804279	1	1	0	0		1	0	0	0	2.043111	0	0.540000	1.930000	0.540000	0.180000	1.200000e-01	0.260000	0.190000	0.193911	0.180000	0	1.500000e-01	0.230000
HRASLS5	117245	broad.mit.edu	37	11	63257751	63257751	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr11:63257751G>A	ENST00000301790.4	-	2	392	c.233C>T	c.(232-234)cCg>cTg	p.P78L	HRASLS5_ENST00000540857.1_Missense_Mutation_p.P68L|HRASLS5_ENST00000539221.1_Missense_Mutation_p.P78L			Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5			14					TAATGTGCCCGGCGGAGGCTG	0.493000																								0							SO:0001583	missense			ENST00000301790.4	1	1	hg19	CCDS8044.1	.	.	.	.	.	.	.	.	.	.	G	9.547	1.114974	0.20795	.	.	ENSG00000168004	ENST00000540857;ENST00000539221;ENST00000301790	T;T;T	0.26373	1.74;2.24;1.75	3.67	-1.79	0.07932	.	2.087150	0.02276	N	0.068944	T	0.13884	0.0336	N	0.14661	0.345	0.09310	N	1	B;P;B	0.41673	0.041;0.759;0.056	B;B;B	0.28305	0.016;0.088;0.019	T	0.38067	-0.9678	10	0.51188	T	0.08	-2.3493	10.9222	0.47171	0.0:0.0:0.5125:0.4875	.	78;68;78	F5GZ87;F5H4Y9;Q96KN8	.;.;HRSL5_HUMAN	L	68;78;78	ENSP00000444809:P68L;ENSP00000443873:P78L;ENSP00000301790:P78L	ENSP00000301790:P78L	P	-	2	0	HRASLS5	63014327	0.000000	0.05858	0.000000	0.03702	0.000000	0.00434	-0.368000	0.07543	-0.331000	0.08501	-1.142000	0.01873	CCG		TCGA-Q3-AA2A-01A-11D-A377-08	HRASLS5-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000396375.1	1	0	1	428	1039	0	287		0	0	0	0	287	2		0	0	0	0	0	2	1	1.000000	426	1026	0	286	2		0	0	0	0	287	2	-20.000000	1	1	0	0		1	0	0	0	2.043111	0	0.540000	1.930000	0.540000	0.990000	9.800000e-01	1.000000	1.000000	0.999439	0.990000	1	9.900000e-01	1.000000
BTBD11	121551	broad.mit.edu	37	12	107937864	107937864	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr12:107937864G>A	ENST00000280758.5	+	3	1966	c.1438G>A	c.(1438-1440)Gaa>Aaa	p.E480K	BTBD11_ENST00000490090.2_Missense_Mutation_p.E480K|BTBD11_ENST00000420571.2_Missense_Mutation_p.E480K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11			53					CCCACAAATGGAATGGGAAAA	0.582000																								0							SO:0001583	missense			ENST00000280758.5	1	1	hg19	CCDS31893.1	.	.	.	.	.	.	.	.	.	.	G	34	5.356457	0.95854	.	.	ENSG00000151136	ENST00000280758;ENST00000420571;ENST00000490090;ENST00000550706;ENST00000415943	T;T;T;T;T	0.48522	0.81;0.81;0.81;0.81;0.81	5.66	5.66	0.87406	.	0.000000	0.85682	D	0.000000	T	0.71863	0.3390	M	0.77486	2.375	0.80722	D	1	D;D;D	0.89917	0.998;0.997;1.0	D;D;D	0.91635	0.991;0.98;0.999	T	0.74150	-0.3758	10	0.72032	D	0.01	.	19.76	0.96311	0.0:0.0:1.0:0.0	.	480;480;480	A6QL63-2;A6QL63;A6QL63-3	.;BTBDB_HUMAN;.	K	480;480;480;111;114	ENSP00000280758:E480K;ENSP00000413889:E480K;ENSP00000447319:E480K;ENSP00000447606:E111K;ENSP00000407416:E114K	ENSP00000280758:E480K	E	+	1	0	BTBD11	106461994	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	9.852000	0.99516	2.666000	0.90696	0.655000	0.94253	GAA		TCGA-Q3-AA2A-01A-11D-A377-08	BTBD11-003	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000318003.1	1	0	1	40	194	0	53		0	0	0	0	53	2		0	0	0	0	0	2	1	1.000000	39	191	0	53	2		0	0	0	0	53	2	-20.000000	1	1	0	0		1	0	2	2	2.089950	1	0.540000	1.930000	0.540000	0.660000	4.700000e-01	1.000000	0.630000	0.715043	0.660000	0	5.500000e-01	1.000000
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	KRAS_deep			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr12:25398284C>A	ENST00000256078.4	-	2	98	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	1	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	27.2	4.808637	0.90707	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78707	-1.2;-1.2;-1.2;-1.2	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.90373	0.6987	M	0.90650	3.135	0.80722	D	1	D;D	0.76494	0.997;0.999	D;D	0.72625	0.969;0.978	D	0.91773	0.5429	10	0.72032	D	0.01	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	V	12	ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V	ENSP00000256078:G12V	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-Q3-AA2A-01A-11D-A377-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	1	109	241	0	55	0	0	1	0	0	55	2	1	1	168	376	0	386	2	1	1.000000	108	237	0	55	2	1	1	3289	4738	0	55	2	-20.000000	1	1	0	0		1	0	2	2	2.089950	1	0.540000	1.930000	0.540000	0.990000	9.800000e-01	1.000000	1.000000	0.998816	0.990000	1	9.900000e-01	1.000000
ITFG2	55846	broad.mit.edu	37	12	2929350	2929350	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr12:2929350G>A	ENST00000228799.2	+	5	644	c.505G>A	c.(505-507)Ggg>Agg	p.G169R	ITFG2_ENST00000542548.1_Missense_Mutation_p.G57R|ITFG2_ENST00000419778.2_5'UTR	NM_018463.3	NP_060933.3	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2			19			OV - Ovarian serous cystadenocarcinoma(31;0.000818)		ACATCTGACAGGGCAGCTGGT	0.597000																								0							SO:0001583	missense			ENST00000228799.2	0	1	hg19	CCDS8513.1	.	.	.	.	.	.	.	.	.	.	G	28.4	4.914335	0.92178	.	.	ENSG00000111203	ENST00000228799;ENST00000542548	T;T	0.73152	-0.72;1.97	4.58	4.58	0.56647	.	0.000000	0.85682	D	0.000000	D	0.84566	0.5500	M	0.80616	2.505	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	D	0.87007	0.2120	10	0.72032	D	0.01	-0.3388	16.5494	0.84464	0.0:0.0:1.0:0.0	.	169	Q969R8	ITFG2_HUMAN	R	169;57	ENSP00000228799:G169R;ENSP00000437870:G57R	ENSP00000228799:G169R	G	+	1	0	ITFG2	2799611	1.000000	0.71417	0.982000	0.44146	0.944000	0.59088	9.238000	0.95380	2.384000	0.81235	0.561000	0.74099	GGG		TCGA-Q3-AA2A-01A-11D-A377-08	ITFG2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000253091.1	1	0	0	5	110	0	22	1	4.095629e-01	2	26	0	22	2		0	0	0	0	0	2	1	0.938952	5	110	0	22	2		0	0	0	0	22	2	-8.212047	1	1	0	0		1	0	3	3	2.104904	1	0.540000	1.930000	0.561320	0.190000	7.000000e-02	1.000000	0.170000	0.309385	0.190000	0	1.200000e-01	0.380000
TFDP1	7027	broad.mit.edu	37	13	114265370	114265370	+	Silent	SNP	C	C	T	rs144432965	byFrequency	TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr13:114265370C>T	ENST00000375370.5	+	3	284	c.72C>T	c.(70-72)ccC>ccT	p.P24P	TFDP1_ENST00000544902.1_5'UTR|TFDP1_ENST00000465174.1_3'UTR|TFDP1_ENST00000538138.1_5'UTR	NM_007111.4	NP_009042.1	Q14186	TFDP1_HUMAN	transcription factor Dp-1			26	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)		ACCTTAGTCCCGGGAAAGGTA	0.443000										TSP Lung(29;0.18)														0							SO:0001819	synonymous_variant			ENST00000375370.5	1	1	hg19	CCDS9538.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	TFDP1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000045918.3	1	0	1	110	358	0	104	1	9.768027e-01	8	14	0	104	2		0	0	0	0	0	2	1	1.000000	110	357	0	104	2		0	0	0	0	104	2	-3.930518	1	1	121412	5	41	1	0	0	0	2.004205	0	0.540000	1.930000	0.534978	0.850000	7.200000e-01	1.000000	0.860000	0.862681	0.850000	1	7.800000e-01	0.930000
MTUS2	23281	broad.mit.edu	37	13	29600312	29600312	+	Missense_Mutation	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr13:29600312C>T	ENST00000431530.3	+	1	1565	c.1507C>T	c.(1507-1509)Cgc>Tgc	p.R503C		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2			20					TCAAAGTGGCCGCTCAGAAGC	0.502000																								0							SO:0001583	missense			ENST00000431530.3	1	1	hg19	CCDS45022.1	.	.	.	.	.	.	.	.	.	.	c	13.08	2.130528	0.37630	.	.	ENSG00000132938	ENST00000431530	T	0.12039	2.72	5.92	-8.99	0.00751	.	1.333950	0.04700	N	0.415575	T	0.04907	0.0132	N	0.08118	0	0.09310	N	1	B	0.02656	0.0	B	0.04013	0.001	T	0.38693	-0.9649	9	.	.	.	.	5.915	0.19050	0.1411:0.5246:0.2381:0.0962	.	493	Q5JR59	MTUS2_HUMAN	C	503	ENSP00000392057:R503C	.	R	+	1	0	MTUS2	28498312	0.000000	0.05858	0.000000	0.03702	0.003000	0.03518	-0.104000	0.10923	-0.703000	0.05049	-1.283000	0.01379	CGC		TCGA-Q3-AA2A-01A-11D-A377-08	MTUS2-002	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000044336.3	1	0	1	40	154	0	36		0	0	0	0	36	2		0	0	0	0	0	2	1	1.000000	40	150	0	36	2		0	0	0	0	36	2	-20.000000	1	1	120900	2	36	1	0	0	0	2.004205	0	0.540000	1.930000	0.534978	0.750000	5.600000e-01	0.960000	0.750000	0.762238	0.750000	0	6.500000e-01	0.860000
MAB21L1	4081	broad.mit.edu	37	13	36049899	36049899	+	Missense_Mutation	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr13:36049899C>T	ENST00000379919.4	-	1	933	c.377G>A	c.(376-378)cGc>cAc	p.R126H	NBEA_ENST00000310336.4_Intron|NBEA_ENST00000540320.1_Intron|NBEA_ENST00000537702.1_5'Flank|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000379939.2_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)			20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)			CCGGATTTTGCGCGCCGAGAG	0.587000																								0							SO:0001583	missense			ENST00000379919.4	0	1	hg19	CCDS9353.1	.	.	.	.	.	.	.	.	.	.	C	24.5	4.533938	0.85812	.	.	ENSG00000180660	ENST00000379919	T	0.08634	3.07	5.66	5.66	0.87406	.	0.000000	0.85682	D	0.000000	T	0.35799	0.0944	M	0.84433	2.695	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	T	0.06679	-1.0813	10	0.46703	T	0.11	-0.3257	19.7375	0.96212	0.0:1.0:0.0:0.0	.	126	Q13394	MB211_HUMAN	H	126	ENSP00000369251:R126H	ENSP00000369251:R126H	R	-	2	0	MAB21L1	34947899	1.000000	0.71417	1.000000	0.80357	0.994000	0.84299	7.818000	0.86416	2.680000	0.91292	0.655000	0.94253	CGC		TCGA-Q3-AA2A-01A-11D-A377-08	MAB21L1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000044459.3	0	0	0	4	167	0	35		0	0	0	0	35	2		0	0	0	0	0	2	1	0.887125	4	164	0	33	2		0	0	0	0	35	2	-3.082443	1	1	0	0		1	0	0	0	2.004205	0	0.540000	1.930000	0.534978	0.090000	2.000000e-02	0.200000	0.080000	0.105343	0.090000	0	5.000000e-02	0.150000
RNASE7	84659	broad.mit.edu	37	14	21511178	21511178	+	Silent	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr14:21511178C>T	ENST00000298690.4	+	2	284	c.27C>T	c.(25-27)tgC>tgT	p.C9C	NDRG2_ENST00000403829.3_Intron	NM_032572.3	NP_115961	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7			6	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)		CAGGATTCTGCCCCCTTCTGC	0.572000																								0							SO:0001819	synonymous_variant			ENST00000298690.4	0	1	hg19	CCDS41914.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	RNASE7-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000313936.1	0	0	0	4	133	0	29		0	0	0	0	29	2		0	0	0	0	0	2	1	0.889776	4	132	0	29	2		0	0	0	0	29	2	-3.442379	1	1	121404	1	31	1	0	1	1	2.032509	0	0.540000	1.930000	0.538755	0.110000	3.000000e-02	0.250000	0.100000	0.132039	0.110000	0	7.000000e-02	0.190000
C15orf59	388135	broad.mit.edu	37	15	74032307	74032307	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr15:74032307G>A	ENST00000569673.1	-	3	2037	c.833C>T	c.(832-834)aCg>aTg	p.T278M	C15orf59_ENST00000379822.4_Missense_Mutation_p.T278M|C15orf59_ENST00000558834.1_5'UTR			Q2T9L4	CO059_HUMAN	chromosome 15 open reading frame 59			15					GGGCAGAACCGTCTGCGTGCT	0.592000																								0							SO:0001583	missense			ENST00000569673.1	0	1	hg19	CCDS32289.1	.	.	.	.	.	.	.	.	.	.	G	22.8	4.338827	0.81911	.	.	ENSG00000205363	ENST00000379822	T	0.68903	-0.36	5.1	5.1	0.69264	.	0.000000	0.85682	D	0.000000	T	0.79446	0.4447	L	0.55481	1.735	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	T	0.81595	-0.0861	10	0.87932	D	0	.	18.093	0.89480	0.0:0.0:1.0:0.0	.	278	Q2T9L4	CO059_HUMAN	M	278	ENSP00000369150:T278M	ENSP00000369150:T278M	T	-	2	0	C15orf59	71819360	1.000000	0.71417	1.000000	0.80357	0.900000	0.52787	9.060000	0.93907	2.354000	0.79902	0.561000	0.74099	ACG		TCGA-Q3-AA2A-01A-11D-A377-08	C15orf59-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000419077.2	0	0	0	7	881	0	211	0	9.059202e-05	0	2	0	211	2		0	0	0	0	0	2	1	0.978896	7	860	0	202	2		0	0	0	0	211	2	-2.538441	1	1	121410	2	31	1	0	0	0	2.039928	0	0.540000	1.930000	0.540000	0.020000	0	0.060000	0.030000	0.032379	0.020000	0	1.000000e-02	0.050000
USP7	7874	broad.mit.edu	37	16	8988948	8988948	+	Silent	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr16:8988948C>T	ENST00000344836.4	-	28	3177	c.2979G>A	c.(2977-2979)gcG>gcA	p.A993A	USP7_ENST00000381886.4_Silent_p.A977A|USP7_ENST00000535863.1_Silent_p.A894A	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	p.A993A(1)		48					TGTGGAAATGCGCCACTGTGA	0.502000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000344836.4	0	1	hg19	CCDS32385.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	USP7-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000434268.2	0	0	0	7	1251	0	290	0	1.738788e-01	0	117	0	290	2		0	0	0	0	0	2	1	0.979785	7	1237	0	289	2		0	0	0	0	290	2	-1.985829	0	1	121412	7	45	1	1	2	3	2.062951	0	0.540000	1.930000	0.542471	0.010000	0	0.050000	0.020000	0.032276	0.010000	0	0	0.030000
DNAH2	146754	broad.mit.edu	37	17	7708357	7708357	+	Missense_Mutation	SNP	G	G	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr17:7708357G>C	ENST00000572933.1	+	60	10725	c.9265G>C	c.(9265-9267)Gaa>Caa	p.E3089Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.E3089Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2			189		all_cancers(10;4.66e-07)|Prostate(122;0.081)			GAAAGATCTAGAAGAGGCACT	0.582000																								0							SO:0001583	missense			ENST00000572933.1	1	1	hg19	CCDS32551.1	.	.	.	.	.	.	.	.	.	.	G	19.20	3.782129	0.70222	.	.	ENSG00000183914	ENST00000389173	T	0.74209	-0.82	4.88	4.88	0.63580	Dynein heavy chain, coiled coil stalk (1);	0.057608	0.64402	D	0.000002	T	0.71117	0.3302	L	0.37800	1.135	0.80722	D	1	B	0.28258	0.205	B	0.39152	0.292	T	0.66221	-0.5978	10	0.24483	T	0.36	.	16.9512	0.86246	0.0:0.0:1.0:0.0	.	3089	Q9P225	DYH2_HUMAN	Q	3089	ENSP00000373825:E3089Q	ENSP00000373825:E3089Q	E	+	1	0	DNAH2	7649082	1.000000	0.71417	0.998000	0.56505	0.933000	0.57130	6.930000	0.75858	2.541000	0.85698	0.591000	0.81541	GAA		TCGA-Q3-AA2A-01A-11D-A377-08	DNAH2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000440241.1	1	0	1	94	288	0	83	0	6.168831e-02	0	2	0	83	2		0	0	0	0	0	2	1	1.000000	94	286	0	82	2		0	0	0	0	83	2	-20.000000	1	1	0	0		1	1	2	3	2.065784	0	0.540000	1.930000	0.542471	0.910000	7.500000e-01	1.000000	1.000000	0.912645	0.910000	1	8.300000e-01	1.000000
DNAH2	146754	broad.mit.edu	37	17	7708641	7708641	+	Missense_Mutation	SNP	G	G	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr17:7708641G>C	ENST00000572933.1	+	61	10832	c.9372G>C	c.(9370-9372)gaG>gaC	p.E3124D	DNAH2_ENST00000389173.2_Missense_Mutation_p.E3124D			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2			189		all_cancers(10;4.66e-07)|Prostate(122;0.081)			CCCAAGTGGAGATAGTGATGC	0.507000																								0							SO:0001583	missense			ENST00000572933.1	1	1	hg19	CCDS32551.1	.	.	.	.	.	.	.	.	.	.	G	19.93	3.918069	0.73098	.	.	ENSG00000183914	ENST00000360606;ENST00000389173	T	0.57907	0.37	5.62	2.09	0.27110	Dynein heavy chain, coiled coil stalk (1);	0.000000	0.85682	D	0.000000	T	0.52613	0.1745	L	0.43757	1.38	0.80722	D	1	P;P	0.40660	0.48;0.726	B;P	0.51297	0.413;0.665	T	0.42155	-0.9468	10	0.25751	T	0.34	.	10.78	0.46371	0.2594:0.0:0.7406:0.0	.	3085;3124	Q9P225-2;Q9P225	.;DYH2_HUMAN	D	3085;3124	ENSP00000373825:E3124D	ENSP00000353818:E3085D	E	+	3	2	DNAH2	7649366	1.000000	0.71417	0.996000	0.52242	0.993000	0.82548	1.613000	0.36900	0.724000	0.32296	0.655000	0.94253	GAG		TCGA-Q3-AA2A-01A-11D-A377-08	DNAH2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000440241.1	1	0	1	81	252	0	70	0	4.528335e-01	0	6	0	70	2		0	0	0	0	0	2	1	1.000000	81	249	0	70	2		0	0	0	0	70	2	-20.000000	1	0	121412	1	35	1	1	2	3	2.065784	0	0.540000	1.930000	0.542471	0.900000	7.300000e-01	1.000000	1.000000	0.902929	0.900000	1	8.100000e-01	1.000000
DNAH2	146754	broad.mit.edu	37	17	7708672	7708672	+	Missense_Mutation	SNP	G	G	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr17:7708672G>C	ENST00000572933.1	+	61	10863	c.9403G>C	c.(9403-9405)Ggc>Cgc	p.G3135R	DNAH2_ENST00000389173.2_Missense_Mutation_p.G3135R			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2			189		all_cancers(10;4.66e-07)|Prostate(122;0.081)			GATTCTTCGAGGCAACGAGCC	0.502000																								0							SO:0001583	missense			ENST00000572933.1	1	1	hg19	CCDS32551.1	.	.	.	.	.	.	.	.	.	.	G	20.6	4.014629	0.75161	.	.	ENSG00000183914	ENST00000360606;ENST00000389173	D	0.83163	-1.69	5.62	5.62	0.85841	Dynein heavy chain, coiled coil stalk (1);	0.056220	0.64402	D	0.000001	D	0.86104	0.5853	M	0.83774	2.66	0.80722	D	1	B;B	0.32324	0.314;0.364	B;B	0.35240	0.198;0.188	D	0.85682	0.1301	10	0.51188	T	0.08	.	18.4187	0.90579	0.0:0.0:1.0:0.0	.	3096;3135	Q9P225-2;Q9P225	.;DYH2_HUMAN	R	3096;3135	ENSP00000373825:G3135R	ENSP00000353818:G3096R	G	+	1	0	DNAH2	7649397	1.000000	0.71417	0.999000	0.59377	0.991000	0.79684	6.688000	0.74557	2.652000	0.90054	0.655000	0.94253	GGC		TCGA-Q3-AA2A-01A-11D-A377-08	DNAH2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000440241.1	1	0	1	62	230	0	70	0	3.794125e-01	0	5	0	70	2		0	0	0	0	0	2	1	1.000000	62	228	0	69	2		0	0	0	0	70	2	-20.000000	1	0	0	0		1	1	2	3	2.065784	0	0.540000	1.930000	0.542471	0.780000	6.200000e-01	1.000000	0.790000	0.797155	0.780000	0	7.000000e-01	0.890000
SLC14A2	8170	broad.mit.edu	37	18	43246996	43246996	+	Missense_Mutation	SNP	A	A	G			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr18:43246996A>G	ENST00000255226.6	+	13	2470	c.1654A>G	c.(1654-1656)Agg>Ggg	p.R552G	SLC14A2_ENST00000586448.1_Missense_Mutation_p.R552G|SLC14A2_ENST00000589658.1_Missense_Mutation_p.R29G|RP11-116O18.3_ENST00000589510.1_RNA	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2			63					CAGTGGGAAAAGGGTCAGCAA	0.478000																								0							SO:0001583	missense			ENST00000255226.6	0	1	hg19	CCDS11924.1	.	.	.	.	.	.	.	.	.	.	A	6.688	0.495556	0.12762	.	.	ENSG00000132874	ENST00000255226	T	0.36699	1.24	4.37	4.37	0.52481	.	0.340286	0.24960	N	0.034236	T	0.31544	0.0800	L	0.50333	1.59	0.32344	N	0.559296	B	0.12630	0.006	B	0.20955	0.032	T	0.34950	-0.9808	10	0.38643	T	0.18	-7.2644	9.2009	0.37258	0.8181:0.1819:0.0:0.0	.	552	Q15849	UT2_HUMAN	G	552	ENSP00000255226:R552G	ENSP00000255226:R552G	R	+	1	2	SLC14A2	41500994	0.038000	0.19896	0.307000	0.25127	0.095000	0.18619	0.812000	0.27211	1.827000	0.53221	0.533000	0.62120	AGG		TCGA-Q3-AA2A-01A-11D-A377-08	SLC14A2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255858.1	0	0	0	4	133	0	43		0	0	0	0	43	2		0	0	0	0	0	2	1	0.886233	4	130	0	43	2		0	0	0	0	43	2	-3.620490	1	1	0	0		1	0	1	1	1.515976	1	0.540000	1.930000	0.369863	0.080000	2.000000e-02	0.180000	0.080000	0.096046	0.080000	0	4.000000e-02	0.140000
CELF5	60680	broad.mit.edu	37	19	3290280	3290280	+	Missense_Mutation	SNP	A	A	G			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr19:3290280A>G	ENST00000292672.2	+	11	1275	c.1238A>G	c.(1237-1239)gAc>gGc	p.D413G	CELF5_ENST00000541430.2_Silent_p.R374R	NM_021938.3	NP_068757.2	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5			13					GAGTTTGGAGACACGGAGCTG	0.542000																								0							SO:0001583	missense			ENST00000292672.2	0	1	hg19	CCDS12106.1	.	.	.	.	.	.	.	.	.	.	A	22.9	4.355769	0.82243	.	.	ENSG00000161082	ENST00000292672	T	0.17370	2.28	4.32	4.32	0.51571	Nucleotide-binding, alpha-beta plait (1);RNA recognition motif domain (3);	0.000000	0.85682	D	0.000000	T	0.44993	0.1320	M	0.86178	2.8	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	T	0.52419	-0.8578	10	0.87932	D	0	-20.3383	12.6476	0.56744	1.0:0.0:0.0:0.0	.	413	Q8N6W0	CELF5_HUMAN	G	413	ENSP00000292672:D413G	ENSP00000292672:D413G	D	+	2	0	CELF5	3241280	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	9.258000	0.95555	1.731000	0.51592	0.443000	0.29094	GAC		TCGA-Q3-AA2A-01A-11D-A377-08	CELF5-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000452574.1	0	0	0	4	297	0	59		0	0	0	0	59	2		0	0	0	0	0	2	1	0.887854	4	293	0	59	2		0	0	0	0	59	2	-2.796573	1	1	0	0		1	1	2	3	2.071170	0	0.540000	1.930000	0.542471	0.050000	0	0.140000	0.050000	0.070352	0.050000	0	2.000000e-02	0.090000
KPTN	11133	broad.mit.edu	37	19	47986554	47986554	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr19:47986554G>A	ENST00000338134.3	-	3	499	c.392C>T	c.(391-393)gCc>gTc	p.A131V	NAPA-AS1_ENST00000594367.1_RNA|KPTN_ENST00000595484.1_5'UTR|KPTN_ENST00000536339.1_5'UTR|NAPA-AS1_ENST00000593284.1_RNA	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)			8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)			TCACTCACGGGCAATAGAGTC	0.617000											OREG0025593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)												0							SO:0001583	missense			ENST00000338134.3	0	1	hg19	CCDS42583.1	.	.	.	.	.	.	.	.	.	.	G	35	5.458714	0.96240	.	.	ENSG00000118162	ENST00000338134	.	.	.	4.51	4.51	0.55191	.	0.000000	0.85682	D	0.000000	T	0.80618	0.4657	M	0.83012	2.62	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.84270	0.0488	9	0.72032	D	0.01	-25.3185	16.3782	0.83418	0.0:0.0:1.0:0.0	.	131	Q9Y664	KPTN_HUMAN	V	131	.	ENSP00000337850:A131V	A	-	2	0	KPTN	52678366	1.000000	0.71417	1.000000	0.80357	0.958000	0.62258	8.893000	0.92498	2.214000	0.71695	0.491000	0.48974	GCC		TCGA-Q3-AA2A-01A-11D-A377-08	KPTN-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000466672.2	0	0	0	5	485	0	130	0	7.122411e-03	0	10	0	130	2		0	0	0	0	0	2	1	0.934753	5	476	0	130	2		0	0	0	0	130	2	-2.023109	0	1	0	0		1	1	2	3	2.067468	0	0.540000	1.930000	0.542471	0.030000	0	0.100000	0.040000	0.054419	0.030000	0	2.000000e-02	0.070000
TSKS	60385	broad.mit.edu	37	19	50243356	50243356	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr19:50243356G>A	ENST00000246801.3	-	10	1664	c.1582C>T	c.(1582-1584)Cgg>Tgg	p.R528W	TSKS_ENST00000358830.3_Missense_Mutation_p.R328W	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate			38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)			TTCTTGGCCCGCAGGGCCTCG	0.627000																								0							SO:0001583	missense			ENST00000246801.3	0	1	hg19	CCDS12780.1	.	.	.	.	.	.	.	.	.	.	G	17.70	3.454044	0.63290	.	.	ENSG00000126467	ENST00000246801;ENST00000358830	T;T	0.49432	0.78;0.78	4.81	3.72	0.42706	.	0.287773	0.24566	N	0.037427	T	0.50309	0.1608	N	0.24115	0.695	0.32826	D	0.50336	D	0.89917	1.0	D	0.72338	0.977	T	0.59663	-0.7412	10	0.87932	D	0	-27.3869	9.3425	0.38089	0.0:0.0:0.7707:0.2293	.	528	Q9UJT2	TSKS_HUMAN	W	528;328	ENSP00000246801:R528W;ENSP00000351691:R328W	ENSP00000246801:R528W	R	-	1	2	TSKS	54935168	0.523000	0.26274	0.989000	0.46669	0.875000	0.50365	2.024000	0.41049	2.490000	0.84030	0.609000	0.83330	CGG		TCGA-Q3-AA2A-01A-11D-A377-08	TSKS-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000465795.1	0	0	0	5	408	1	120		0	0	0	1	120	2		0	0	0	0	0	2	0	0.036004	5	388	1	120	13		0	0	0	1	120	2	-1.872329	0	1	121390	4	44	1	1	2	3	2.067468	0	0.540000	1.930000	0.542471	0.040000	0	0.110000	0.040000	0.062896	0.040000	0	2.000000e-02	0.080000
BCL9	607	broad.mit.edu	37	1	147084715	147084715	+	Silent	SNP	T	T	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr1:147084715T>C	ENST00000234739.3	+	5	827	c.87T>C	c.(85-87)cgT>cgC	p.R29R	BCL9_ENST00000473292.1_3'UTR	NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9			7	all_hematologic(923;0.115)				TGATGGTCCGTCCCCCTACAG	0.502000			T	IGH@, IGL@	B-ALL										Dom	yes		1	1q21	607	B-cell CLL/lymphoma 9		L	0							SO:0001819	synonymous_variant			ENST00000234739.3	0	1	hg19	CCDS30833.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	BCL9-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000039468.1	0	0	0	5	347	0	66	0	3.194699e-03	0	5	0	66	2		0	0	0	0	0	2	1	0.934126	5	339	0	65	2		0	0	0	0	66	2	-2.389524	0	1	0	0		1	0	0	0	2.040689	0	0.540000	1.930000	0.540000	0.050000	1.000000e-02	0.120000	0.060000	0.062573	0.050000	0	3.000000e-02	0.090000
PTPRF	5792	broad.mit.edu	37	1	44064491	44064491	+	Silent	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr1:44064491G>A	ENST00000359947.4	+	13	2560	c.2220G>A	c.(2218-2220)caG>caA	p.Q740Q	PTPRF_ENST00000438120.1_Silent_p.Q740Q|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372414.3_Silent_p.Q740Q|PTPRF_ENST00000372413.3_Silent_p.Q740Q|PTPRF_ENST00000422171.2_Silent_p.Q97Q	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F			72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)			AGCATGGCCAGATCCGCGGCT	0.647000																								0							SO:0001819	synonymous_variant			ENST00000359947.4	1	1	hg19	CCDS489.2	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	8.913|8.913	0.959151|0.959151	0.18507|0.18507	.|.	.|.	ENSG00000142949|ENSG00000142949	ENST00000412568;ENST00000414879|ENST00000429895	.|.	.|.	.|.	4.35|4.35	4.35|4.35	0.52113|0.52113	.|.	.|.	.|.	.|.	.|.	T|T	0.58308|0.58308	0.2113|0.2113	.|.	.|.	.|.	0.80722|0.80722	D|D	1|1	.|.	.|.	.|.	.|.	.|.	.|.	T|T	0.56062|0.56062	-0.8041|-0.8041	4|4	.|.	.|.	.|.	.|.	8.5321|8.5321	0.33340|0.33340	0.1759:0.0:0.8241:0.0|0.1759:0.0:0.8241:0.0	.|.	.|.	.|.	.|.	N|K	306;163|397	.|.	.|.	D|R	+|+	1|2	0|0	PTPRF|PTPRF	43837078|43837078	1.000000|1.000000	0.71417|0.71417	1.000000|1.000000	0.80357|0.80357	0.976000|0.976000	0.68499|0.68499	1.815000|1.815000	0.38981|0.38981	2.143000|2.143000	0.66587|0.66587	0.449000|0.449000	0.29647|0.29647	GAT|AGA		TCGA-Q3-AA2A-01A-11D-A377-08	PTPRF-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000019710.1	0	0	1	38	231	0	66	1	9.626193e-01	5	30	0	66	2		0	0	0	0	0	2	1	1.000000	38	228	0	66	2		0	0	0	0	66	2	-20.000000	1	1	0	0		1	1	2	3	2.063421	0	0.540000	1.930000	0.542471	0.520000	3.800000e-01	0.720000	0.520000	0.538772	0.520000	0	4.500000e-01	0.620000
PRPF38A	84950	broad.mit.edu	37	1	52870463	52870463	+	Silent	SNP	C	C	G			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr1:52870463C>G	ENST00000257181.9	+	1	228	c.42C>G	c.(40-42)ggC>ggG	p.G14G	ORC1_ENST00000371566.1_5'Flank|PRPF38A_ENST00000474048.1_3'UTR|ORC1_ENST00000371568.3_5'Flank	NM_032864.3	NP_116253.2	Q8NAV1	PR38A_HUMAN	pre-mRNA processing factor 38A			9					GCATCCATGGCACCAACCCTC	0.463000											OREG0013487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)												0							SO:0001819	synonymous_variant			ENST00000257181.9	1	1	hg19	CCDS567.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	PRPF38A-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000022459.2	1	0	1	46	332	0	66	1	8.536296e-01	6	21	0	66	2		0	0	0	0	0	2	1	1.000000	46	330	0	66	2		0	0	0	0	66	2	-3.318809	1	0	0	0		1	1	2	3	2.063421	0	0.540000	1.930000	0.542471	0.450000	3.300000e-01	0.600000	0.450000	0.464831	0.450000	0	3.900000e-01	0.520000
ZNFX1	57169	broad.mit.edu	37	20	47871123	47871123	+	Silent	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr20:47871123G>A	ENST00000396105.1	-	10	3114	c.2868C>T	c.(2866-2868)taC>taT	p.Y956Y	ZNFX1_ENST00000371754.4_Silent_p.Y956Y|ZNFX1_ENST00000371752.1_Silent_p.Y956Y	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1			60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		CTGATGTGCGGTACTGGCGTT	0.512000																								0							SO:0001819	synonymous_variant			ENST00000396105.1	0	1	hg19	CCDS13417.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	ZNFX1-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000079647.2	0	0	0	5	647	1	147	0	9.244146e-03	0	15	1	147	2		0	0	0	0	0	2	0	0.011594	5	639	1	145	16		0	0	0	1	147	2	-2.518560	1	1	0	0		1	0	1	1	2.032949	0	0.540000	1.930000	0.538755	0.020000	0	0.070000	0.030000	0.033123	0.020000	0	1.000000e-02	0.050000
CLTCL1	8218	broad.mit.edu	37	22	19209057	19209057	+	Missense_Mutation	SNP	G	G	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr22:19209057G>T	ENST00000263200.10	-	17	2711	c.2639C>A	c.(2638-2640)gCt>gAt	p.A880D	CLTCL1_ENST00000353891.5_Missense_Mutation_p.A880D|CLTCL1_ENST00000427926.1_Missense_Mutation_p.A880D	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1			49	Colorectal(54;0.0993)				GTAGATTTTAGCCAGTGCATT	0.547000			T	?	ALCL										Dom	yes		22	22q11.21	8218	clathrin, heavy polypeptide-like 1		L	0							SO:0001583	missense			ENST00000263200.10	1	1	hg19	CCDS46662.1	.	.	.	.	.	.	.	.	.	.	G	16.30	3.083901	0.55861	.	.	ENSG00000070371	ENST00000353891;ENST00000263200;ENST00000427926	T;T;T	0.23552	1.9;1.9;1.9	3.63	3.63	0.41609	Tetratricopeptide-like helical (1);Armadillo-type fold (1);	0.072624	0.53938	D	0.000042	T	0.60919	0.2306	M	0.93898	3.47	0.80722	D	1	D;D	0.89917	0.999;1.0	D;D	0.97110	0.995;1.0	T	0.74902	-0.3506	10	0.87932	D	0	-3.9812	15.456	0.75314	0.0:0.0:1.0:0.0	.	880;880	P53675-2;P53675	.;CLH2_HUMAN	D	880	ENSP00000439662:A880D;ENSP00000445677:A880D;ENSP00000441158:A880D	ENSP00000445677:A880D	A	-	2	0	CLTCL1	17589057	1.000000	0.71417	0.968000	0.41197	0.008000	0.06430	8.761000	0.91691	1.880000	0.54463	0.462000	0.41574	GCT		TCGA-Q3-AA2A-01A-11D-A377-08	CLTCL1-001	KNOWN	non_canonical_genome_sequence_error|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000316397.5	1	0	1	14	60	0	15	0	4.101162e-02	0	2	0	15	2		0	0	0	0	0	2	1	0.999823	15	57	0	15	2		0	0	0	0	15	2	-20.000000	1	1	0	0		1	1	2	3	2.071007	0	0.540000	1.930000	0.542471	0.710000	4.200000e-01	1.000000	1.000000	0.724270	0.710000	0	5.500000e-01	0.900000
TTN	7273	broad.mit.edu	37	2	179410378	179410378	+	Missense_Mutation	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr2:179410378C>T	ENST00000591111.1	-	294	90760	c.90536G>A	c.(90535-90537)gGc>gAc	p.G30179D	TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G29252D|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G22755D|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000589042.1_Missense_Mutation_p.G31820D|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G22947D|TTN_ENST00000359218.5_Missense_Mutation_p.G22880D|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592600.1_RNA			Q8WZ42	TITIN_HUMAN	titin			1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)		ATGCTCTTTGCCAGTCCCAAC	0.423000																								0							SO:0001583	missense			ENST00000591111.1	0	1	hg19		.	.	.	.	.	.	.	.	.	.	C	18.40	3.615238	0.66672	.	.	ENSG00000155657	ENST00000342992;ENST00000460472;ENST00000342175;ENST00000359218;ENST00000356127	T;T;T;T	0.58652	0.32;0.32;0.32;0.32	5.82	5.82	0.92795	Fibronectin, type III (4);Peptidase C2, calpain, large subunit, domain III (1);Ribonuclease H-like (1);Immunoglobulin-like fold (1);	.	.	.	.	T	0.64034	0.2562	N	0.25957	0.775	0.53005	D	0.999965	D;D;D;D	0.60160	0.987;0.987;0.987;0.987	P;P;P;P	0.58620	0.842;0.842;0.842;0.842	T	0.66787	-0.5835	9	0.87932	D	0	.	20.1086	0.97902	0.0:1.0:0.0:0.0	.	22755;22880;22947;30179	D3DPF9;E7EQE6;E7ET18;Q8WZ42	.;.;.;TITIN_HUMAN	D	29252;22755;22947;22880;22752	ENSP00000343764:G29252D;ENSP00000434586:G22755D;ENSP00000340554:G22947D;ENSP00000352154:G22880D	ENSP00000340554:G22947D	G	-	2	0	TTN	179118624	1.000000	0.71417	1.000000	0.80357	0.967000	0.64934	6.089000	0.71384	2.756000	0.94617	0.563000	0.77884	GGC		TCGA-Q3-AA2A-01A-11D-A377-08	TTN-019	PUTATIVE	basic	protein_coding	protein_coding	OTTHUMT00000460310.1	0	0	0	7	833	0	173	0	0	0	1	0	173	2		0	0	0	0	0	2	1	0.980131	7	828	0	172	2		0	0	0	0	173	2	-1.942573	0	1	0	0		1	0	0	0	2.015128	0	0.540000	1.930000	0.534978	0.020000	0	0.060000	0.040000	0.034226	0.020000	0	1.000000e-02	0.050000
SLC1A4	6509	broad.mit.edu	37	2	65245311	65245311	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr2:65245311G>A	ENST00000234256.3	+	6	1384	c.1141G>A	c.(1141-1143)Gga>Aga	p.G381R	SLC1A4_ENST00000531327.1_Missense_Mutation_p.G83R	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4			13				L-Alanine(DB00160)	GAACATGGACGGAGCAGCCAT	0.512000																								0							SO:0001583	missense			ENST00000234256.3	0	1	hg19	CCDS1879.1	.	.	.	.	.	.	.	.	.	.	G	35	5.576656	0.96565	.	.	ENSG00000115902	ENST00000531327;ENST00000448784;ENST00000234256	D;D	0.84370	-1.84;-1.84	6.17	6.17	0.99709	Sodium:dicarboxylate symporter, conserved site (1);	0.000000	0.85682	D	0.000000	D	0.96122	0.8736	H	0.98664	4.295	0.80722	D	1	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.97110	1.0;1.0;1.0	D	0.96776	0.9572	9	.	.	.	-12.7631	20.8794	0.99867	0.0:0.0:1.0:0.0	.	381;83;381	P43007;B7Z3C0;B2R7N6	SATT_HUMAN;.;.	R	83;301;381	ENSP00000431942:G83R;ENSP00000234256:G381R	.	G	+	1	0	SLC1A4	65098815	1.000000	0.71417	0.283000	0.24790	0.980000	0.70556	9.869000	0.99810	2.941000	0.99782	0.655000	0.94253	GGA		TCGA-Q3-AA2A-01A-11D-A377-08	SLC1A4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000251726.2	0	0	0	5	357	0	81	0	4.472958e-03	0	6	0	81	2		0	0	0	0	0	2	1	0.934703	5	350	0	81	2		0	0	0	0	81	2	-2.668004	1	1	0	0		1	0	1	1	2.032441	0	0.540000	1.930000	0.538755	0.050000	1.000000e-02	0.110000	0.060000	0.060706	0.050000	0	3.000000e-02	0.080000
ITGB1BP1	9270	broad.mit.edu	37	2	9547660	9547660	+	Missense_Mutation	SNP	G	G	A	rs17850889	byFrequency	TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr2:9547660G>A	ENST00000360635.3	-	7	1345	c.449C>T	c.(448-450)gCg>gTg	p.A150V	ITGB1BP1_ENST00000456913.2_Missense_Mutation_p.A150V|ITGB1BP1_ENST00000355346.4_Missense_Mutation_p.A150V|ITGB1BP1_ENST00000488451.1_Intron|ITGB1BP1_ENST00000359712.3_Missense_Mutation_p.A150V|ITGB1BP1_ENST00000238091.4_Intron|ITGB1BP1_ENST00000490426.1_5'UTR			O14713	ITBP1_HUMAN	integrin beta 1 binding protein 1			8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)				GCTTTTTCCCGCCCCCAGACC	0.483000																								0							SO:0001583	missense			ENST00000360635.3	1	1	hg19	CCDS1662.1	.	.	.	.	.	.	.	.	.	.	G	33	5.278080	0.95459	4.54E-4	1.16E-4	ENSG00000119185	ENST00000360635;ENST00000355346;ENST00000359712;ENST00000456913	.	.	.	5.61	5.61	0.85477	Phosphotyrosine interaction domain (1);Pleckstrin homology-type (1);	0.000000	0.85682	D	0.000000	T	0.59582	0.2204	N	0.24115	0.695	0.80722	D	1	D;D;P	0.71674	0.998;0.99;0.944	P;P;P	0.55011	0.766;0.688;0.507	T	0.57159	-0.7859	9	0.36615	T	0.2	-23.8728	20.0086	0.97443	0.0:0.0:1.0:0.0	rs17850889	106;150;150	B4DQY5;A8MPU2;O14713	.;.;ITBP1_HUMAN	V	150	.	ENSP00000347504:A150V	A	-	2	0	ITGB1BP1	9465111	1.000000	0.71417	0.978000	0.43139	0.990000	0.78478	6.824000	0.75288	2.808000	0.96608	0.655000	0.94253	GCG		TCGA-Q3-AA2A-01A-11D-A377-08	ITGB1BP1-005	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000314623.2	1	0	1	87	201	0	57	1	1	6	125	0	57	2		0	0	0	0	0	2	1	1.000000	85	197	0	57	2		0	0	0	0	57	2	-7.863670	1	1	121412	17	44	1	0	1	1	2.032441	0	0.540000	1.930000	0.538755	0.990000	9.200000e-01	1.000000	1.000000	0.994599	0.990000	1	9.900000e-01	1.000000
UROC1	131669	broad.mit.edu	37	3	126218205	126218205	+	Missense_Mutation	SNP	G	G	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr3:126218205G>T	ENST00000290868.2	-	13	1344	c.1291C>A	c.(1291-1293)Cct>Act	p.P431T	UROC1_ENST00000383579.3_Missense_Mutation_p.P491T	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1			39					ACATAGGAAGGGTAGCGGAAC	0.627000																								0							SO:0001583	missense			ENST00000290868.2	1	1	hg19	CCDS3038.1	.	.	.	.	.	.	.	.	.	.	G	18.26	3.583912	0.65992	.	.	ENSG00000159650	ENST00000290868;ENST00000383579	T;T	0.64438	-0.1;-0.1	4.89	4.89	0.63831	Urocanase domain (2);	0.000000	0.85682	D	0.000000	D	0.85371	0.5681	H	0.95850	3.73	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.97110	1.0;1.0	D	0.90105	0.4187	10	0.72032	D	0.01	0.5184	15.5628	0.76262	0.0:0.0:1.0:0.0	.	491;431	E9PE13;Q96N76	.;HUTU_HUMAN	T	431;491	ENSP00000290868:P431T;ENSP00000373073:P491T	ENSP00000290868:P431T	P	-	1	0	UROC1	127700895	1.000000	0.71417	1.000000	0.80357	0.484000	0.33280	9.216000	0.95154	2.262000	0.75019	0.585000	0.79938	CCT		TCGA-Q3-AA2A-01A-11D-A377-08	UROC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000370325.2	1	0	1	27	105	0	27		0	0	0	0	27	2		0	0	0	0	0	2	1	1.000000	27	105	0	27	2		0	0	0	0	27	2	-20.000000	1	1	0	0		1	0	0	0	2.040625	0	0.540000	1.930000	0.540000	0.750000	5.200000e-01	1.000000	1.000000	0.766332	0.750000	0	6.300000e-01	0.890000
CNTN3	5067	broad.mit.edu	37	3	74344358	74344358	+	Missense_Mutation	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr3:74344358C>T	ENST00000263665.6	-	18	2458	c.2431G>A	c.(2431-2433)Gca>Aca	p.A811T		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)			83		Lung NSC(201;0.138)|Lung SC(41;0.21)			AGGCTATTTGCAGAGACTTGA	0.383000																								0							SO:0001583	missense			ENST00000263665.6	1	1	hg19	CCDS33790.1	.	.	.	.	.	.	.	.	.	.	C	25.3	4.619386	0.87460	.	.	ENSG00000113805	ENST00000263665	T	0.60299	0.2	5.63	5.63	0.86233	Fibronectin, type III (4);Immunoglobulin-like fold (1);	0.176408	0.50627	D	0.000108	T	0.62196	0.2408	M	0.63843	1.955	0.51233	D	0.999919	B	0.27166	0.17	B	0.37692	0.256	T	0.62863	-0.6764	10	0.59425	D	0.04	.	14.528	0.67902	0.1464:0.8535:0.0:0.0	.	811	Q9P232	CNTN3_HUMAN	T	811	ENSP00000263665:A811T	ENSP00000263665:A811T	A	-	1	0	CNTN3	74427048	1.000000	0.71417	0.435000	0.26784	0.996000	0.88848	5.357000	0.66058	2.649000	0.89929	0.650000	0.86243	GCA		TCGA-Q3-AA2A-01A-11D-A377-08	CNTN3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000352306.1	1	0	1	90	243	0	72	1	2.991880e-01	3	1	0	72	2		0	0	0	0	0	2	1	1.000000	88	240	0	72	2		0	0	0	0	72	2	-20.000000	1	1	121406	1	33	1	0	0	0	2.040625	0	0.540000	1.930000	0.540000	0.990000	8.200000e-01	1.000000	1.000000	0.965860	0.990000	1	9.000000e-01	1.000000
GABRR3	200959	broad.mit.edu	37	3	97744480	97744480	+	RNA	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr3:97744480G>A	ENST00000472788.1	-	0	170					NM_001105580.2	NP_001099050.1	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)			3				Adinazolam(DB00546)|Bromazepam(DB01558)|Cinolazepam(DB01594)|Clotiazepam(DB01559)|Diazepam(DB00829)|Estazolam(DB01215)|Fludiazepam(DB01567)|Flurazepam(DB00690)|Halazepam(DB00801)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Prazepam(DB01588)|Quazepam(DB01589)|Temazepam(DB00231)|Triazolam(DB00897)	TTCTGAGGCCGCGCTTTGGTA	0.383000																								0											ENST00000472788.1	1	1	hg19																																																																																					TCGA-Q3-AA2A-01A-11D-A377-08	GABRR3-002	KNOWN	not_organism_supported|basic	polymorphic_pseudogene	polymorphic_pseudogene	OTTHUMT00000353445.2	0	0	0	41	118	0	31		0	0	0	0	31	2		0	0	0	0	0	2	1	1.000000	41	118	0	30	2		0	0	0	0	31	2	-20.000000	1	1	120784	3	35	1	0	0	0	2.040625	0	0.540000	1.930000	0.540000	0.950000	7.100000e-01	1.000000	1.000000	0.926947	0.950000	1	8.200000e-01	1.000000
C4orf50	389197	broad.mit.edu	37	4	5969155	5969155	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr4:5969155G>A	ENST00000324058.5	-	5	532	c.443C>T	c.(442-444)aCg>aTg	p.T148M	C4orf50_ENST00000531445.1_Missense_Mutation_p.T622M			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50			15					TAAAGCTGCCGTCATCTCAGA	0.532000																								0							SO:0001583	missense			ENST00000324058.5	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	13.64	2.296676	0.40594	.	.	ENSG00000181215	ENST00000531445;ENST00000324058	T;T	0.27720	1.65;1.65	2.99	2.99	0.34606	.	0.665167	0.13125	N	0.411927	T	0.47340	0.1440	L	0.56769	1.78	0.09310	N	1	D	0.89917	1.0	D	0.67900	0.954	T	0.17289	-1.0374	10	0.72032	D	0.01	-2.3166	9.7214	0.40306	0.0:0.0:1.0:0.0	.	148	Q6ZRC1	CD050_HUMAN	M	622;148	ENSP00000437121:T622M;ENSP00000317287:T148M	ENSP00000317287:T148M	T	-	2	0	C4orf50	6020056	0.002000	0.14202	0.003000	0.11579	0.140000	0.21249	1.108000	0.31123	1.992000	0.58205	0.655000	0.94253	ACG		TCGA-Q3-AA2A-01A-11D-A377-08	C4orf50-201	KNOWN	basic|appris_candidate	protein_coding	protein_coding		0	0	0	12	458	0	99		0	0	0	0	99	2		0	0	0	0	0	2	1	0.999091	12	454	0	99	2		0	0	0	0	99	2	-3.404082	1	1	121412	1	40	1	1	2	3	2.048279	0	0.540000	1.930000	0.541239	0.090000	4.000000e-02	0.170000	0.100000	0.102103	0.090000	0	6.000000e-02	0.130000
BMP3	651	broad.mit.edu	37	4	81967241	81967241	+	Silent	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr4:81967241G>A	ENST00000282701.2	+	2	986	c.666G>A	c.(664-666)acG>acA	p.T222T		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3			29					TTAACATTACGTCCAAGGGAC	0.438000																								0							SO:0001819	synonymous_variant			ENST00000282701.2	0	1	hg19	CCDS3588.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	BMP3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252634.1	0	0	0	13	623	0	110		0	0	0	0	110	2		0	0	0	0	0	2	1	0.999507	13	617	0	109	2		0	0	0	0	110	2	-2.758140	1	1	121412	8	45	1	1	2	3	2.048279	0	0.540000	1.930000	0.541239	0.070000	3.000000e-02	0.130000	0.080000	0.081389	0.070000	0	5.000000e-02	0.100000
PCDHGA10	56106	broad.mit.edu	37	5	140794655	140794655	+	Missense_Mutation	SNP	A	A	G			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr5:140794655A>G	ENST00000398610.2	+	1	1913	c.1913A>G	c.(1912-1914)gAc>gGc	p.D638G	PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB7_ENST00000398594.2_5'Flank|PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10			43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		GCCCTGCTGGACAGAGACGCG	0.701000																								0							SO:0001583	missense			ENST00000398610.2	1	1	hg19	CCDS47292.1	.	.	.	.	.	.	.	.	.	.	a	17.83	3.486542	0.63962	.	.	ENSG00000253846	ENST00000398610	T	0.65178	-0.14	5.39	5.39	0.77823	Cadherin (4);Cadherin-like (1);	.	.	.	.	T	0.75882	0.3910	M	0.64404	1.975	0.31302	N	0.688228	D;D	0.59767	0.973;0.986	P;D	0.65573	0.786;0.936	T	0.78705	-0.2100	9	0.72032	D	0.01	.	15.1502	0.72692	1.0:0.0:0.0:0.0	.	638;638	Q9Y5H3-2;Q9Y5H3	.;PCDGA_HUMAN	G	638	ENSP00000381611:D638G	ENSP00000381611:D638G	D	+	2	0	PCDHGA10	140774839	1.000000	0.71417	1.000000	0.80357	0.717000	0.41224	4.721000	0.61951	2.061000	0.61500	0.454000	0.30748	GAC		TCGA-Q3-AA2A-01A-11D-A377-08	PCDHGA10-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000374747.1	1	0	1	56	411	0	122		0	0	0	0	122	2		0	0	0	0	0	2	1	1.000000	55	400	0	119	2		0	0	0	0	122	2	-20.000000	1	1	0	0		1	0	0	0	2.036714	0	0.540000	1.930000	0.540000	0.440000	3.300000e-01	0.560000	0.440000	0.449300	0.440000	0	3.800000e-01	0.500000
GALNT10	55568	broad.mit.edu	37	5	153760011	153760011	+	Missense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr5:153760011G>A	ENST00000297107.6	+	6	895	c.758G>A	c.(757-759)cGc>cAc	p.R253H	SAP30L-AS1_ENST00000519727.1_RNA|GALNT10_ENST00000519544.1_3'UTR|GALNT10_ENST00000425427.2_Missense_Mutation_p.R253H|GALNT10_ENST00000377661.2_Missense_Mutation_p.R191H	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	polypeptide N-acetylgalactosaminyltransferase 10			32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)		TCTTCAGACCGCATTGCTCGG	0.502000																								0							SO:0001583	missense			ENST00000297107.6	0	1	hg19	CCDS4325.1	.	.	.	.	.	.	.	.	.	.	G	20.7	4.038191	0.75617	.	.	ENSG00000164574	ENST00000425427;ENST00000297107;ENST00000377661	T;T;T	0.61742	0.08;0.08;0.22	5.41	5.41	0.78517	Glycosyl transferase, family 2 (1);	0.052285	0.85682	D	0.000000	T	0.70029	0.3177	M	0.67625	2.065	0.80722	D	1	D;D;D	0.76494	0.991;0.999;0.997	P;P;P	0.59288	0.855;0.801;0.607	T	0.71487	-0.4578	10	0.51188	T	0.08	.	14.7691	0.69662	0.0:0.1441:0.8559:0.0	.	191;253;253	Q86SR1-2;Q86SR1;Q86SR1-3	.;GLT10_HUMAN;.	H	253;253;191	ENSP00000415210:R253H;ENSP00000297107:R253H;ENSP00000366889:R191H	ENSP00000297107:R253H	R	+	2	0	GALNT10	153740204	1.000000	0.71417	0.998000	0.56505	0.959000	0.62525	6.457000	0.73505	2.535000	0.85469	0.462000	0.41574	CGC		TCGA-Q3-AA2A-01A-11D-A377-08	GALNT10-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252453.1	0	0	0	5	537	0	125	0	2.833145e-03	0	7	0	125	2		0	0	0	0	0	2	1	0.936583	5	533	0	125	2		0	0	0	0	125	2	-1.860100	0	1	121412	1	34	1	0	0	0	2.036714	0	0.540000	1.930000	0.540000	0.030000	0	0.080000	0.040000	0.040351	0.030000	0	1.000000e-02	0.060000
OSMR	9180	broad.mit.edu	37	5	38881767	38881767	+	Missense_Mutation	SNP	T	T	C			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr5:38881767T>C	ENST00000274276.3	+	4	721	c.319T>C	c.(319-321)Tgt>Cgt	p.C107R	OSMR_ENST00000502536.1_Missense_Mutation_p.C107R	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor			46	all_lung(31;0.000365)				CCCTTTGGAATGTGCCACACA	0.473000																								0							SO:0001583	missense			ENST00000274276.3	1	1	hg19	CCDS3928.1	.	.	.	.	.	.	.	.	.	.	T	16.77	3.215522	0.58452	.	.	ENSG00000145623	ENST00000502536;ENST00000274276	T;T	0.64085	-0.08;-0.08	5.81	5.81	0.92471	.	0.098018	0.85682	D	0.000000	T	0.77948	0.4207	M	0.74881	2.28	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.91635	0.998;0.999	T	0.80571	-0.1323	10	0.87932	D	0	.	12.5437	0.56186	0.0:0.0:0.0:1.0	.	107;107	Q99650;Q99650-2	OSMR_HUMAN;.	R	107	ENSP00000422023:C107R;ENSP00000274276:C107R	ENSP00000274276:C107R	C	+	1	0	OSMR	38917524	1.000000	0.71417	0.998000	0.56505	0.409000	0.31022	4.331000	0.59273	2.216000	0.71823	0.533000	0.62120	TGT		TCGA-Q3-AA2A-01A-11D-A377-08	OSMR-001	KNOWN	basic|appris_principal|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000207609.2	1	0	1	105	331	0	109	1	2.479079e-01	2	2	0	109	2		0	0	0	0	0	2	1	1.000000	104	329	0	108	2		0	0	0	0	109	2	-20.000000	1	1	0	0		1	0	0	0	2.040364	0	0.540000	1.930000	0.540000	0.880000	7.400000e-01	1.000000	1.000000	0.891429	0.880000	1	8.100000e-01	0.970000
ELOVL4	6785	broad.mit.edu	37	6	80635984	80635984	+	Missense_Mutation	SNP	G	G	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr6:80635984G>T	ENST00000369816.4	-	2	515	c.215C>A	c.(214-216)cCt>cAt	p.P72H		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4			22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		Alpha-Linolenic Acid(DB00132)	CATCTGAAAAGGTTCTCGGTC	0.393000																								0							SO:0001583	missense			ENST00000369816.4	1	1	hg19	CCDS4992.1	.	.	.	.	.	.	.	.	.	.	G	29.2	4.983967	0.93044	.	.	ENSG00000118402	ENST00000369816	T	0.26810	1.71	5.85	5.85	0.93711	.	0.000000	0.85682	D	0.000000	T	0.65450	0.2692	H	0.98068	4.14	0.80722	D	1	D	0.89917	1.0	D	0.85130	0.997	T	0.78841	-0.2045	10	0.87932	D	0	-9.8818	19.1531	0.93496	0.0:0.0:1.0:0.0	.	72	Q9GZR5	ELOV4_HUMAN	H	72	ENSP00000358831:P72H	ENSP00000358831:P72H	P	-	2	0	ELOVL4	80692703	1.000000	0.71417	1.000000	0.80357	0.991000	0.79684	9.476000	0.97823	2.753000	0.94483	0.655000	0.94253	CCT		TCGA-Q3-AA2A-01A-11D-A377-08	ELOVL4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000041315.1	1	0	1	77	268	0	68		0	0	0	0	68	2		0	0	0	0	0	2	1	1.000000	77	266	0	68	2		0	0	0	0	68	2	-20.000000	1	1	121408	1	31	1	0	0	0	2.019237	0	0.540000	1.930000	0.537503	0.810000	6.600000e-01	0.980000	0.830000	0.825280	0.810000	0	7.300000e-01	0.910000
MOSPD3	64598	broad.mit.edu	37	7	100211247	100211247	+	Silent	SNP	G	G	A	rs5886124		TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr7:100211247G>A	ENST00000393950.2	+	3	711	c.429G>A	c.(427-429)gaG>gaA	p.E143E	MOSPD3_ENST00000223054.4_Silent_p.E143E|MOSPD3_ENST00000379527.2_Silent_p.E143E|MOSPD3_ENST00000424091.2_Silent_p.E133E	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3			16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)				ACCCCCTTGAGCTTCAGGGAC	0.637000																								0							SO:0001819	synonymous_variant			ENST00000393950.2	1	1	hg19	CCDS5701.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	MOSPD3-002	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000356395.1	1	0	0	20	294	0	76	1	9.812130e-01	6	91	0	76	2		0	0	0	0	0	2	1	0.999996	20	292	0	75	2		0	0	0	0	76	2	-19.999850	1	1	0	0		1	0	0	0	2.037488	0	0.540000	1.930000	0.540000	0.230000	1.400000e-01	0.350000	0.240000	0.245452	0.230000	0	1.800000e-01	0.300000
ZFAND2A	90637	broad.mit.edu	37	7	1195155	1195155	+	Silent	SNP	T	T	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr7:1195155T>A	ENST00000316495.3	-	4	475	c.216A>T	c.(214-216)ccA>ccT	p.P72P	ZFAND2A_ENST00000401903.1_Silent_p.P72P	NM_182491.2	NP_872297.2	Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A			3		Ovarian(82;0.11)			CCACCACGTCTGGTATCTGGC	0.483000																								0							SO:0001819	synonymous_variant			ENST00000316495.3	1	1	hg19	CCDS5323.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	ZFAND2A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000239220.2	0	0	1	138	493	0	116	1	1	31	56	0	116	2		0	0	0	0	0	2	1	1.000000	138	485	0	116	2		0	0	0	0	116	2	-20.000000	1	1	0	0		1	1	2	3	2.488621	1	0.540000	1.930000	0.623383	0.990000	8.400000e-01	1.000000	1.000000	0.970748	0.990000	1	9.100000e-01	1.000000
KRIT1	889	broad.mit.edu	37	7	91865794	91865794	+	Nonsense_Mutation	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr7:91865794G>A	ENST00000340022.2	-	7	1436	c.418C>T	c.(418-420)Cga>Tga	p.R140*	KRIT1_ENST00000412043.2_Nonsense_Mutation_p.R140*|KRIT1_ENST00000394505.2_Nonsense_Mutation_p.R140*|KRIT1_ENST00000394503.2_Nonsense_Mutation_p.R140*|KRIT1_ENST00000394507.1_Nonsense_Mutation_p.R140*	NM_004912.3|NM_194455.1	NP_004903.2|NP_919437.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	p.R140*(1)		22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		CTACAGACTCGCATAATATCT	0.318000																								1	Substitution - Nonsense(1)						SO:0001587	stop_gained			ENST00000340022.2	0	1	hg19	CCDS5624.1	.	.	.	.	.	.	.	.	.	.	G	38	7.271354	0.98179	.	.	ENSG00000001631	ENST00000394507;ENST00000340022;ENST00000412043;ENST00000394505;ENST00000394503;ENST00000415227;ENST00000458177;ENST00000433016;ENST00000454017	.	.	.	5.17	0.483	0.16820	.	0.000000	0.85682	D	0.000000	.	.	.	.	.	.	0.80722	A	1	.	.	.	.	.	.	.	.	.	.	0.02654	T	1	-4.7004	15.7344	0.77831	0.0:0.0:0.2068:0.7932	.	.	.	.	X	140	.	ENSP00000344668:R140X	R	-	1	2	KRIT1	91703730	1.000000	0.71417	1.000000	0.80357	0.874000	0.50279	1.282000	0.33226	0.065000	0.16485	-0.238000	0.12139	CGA		TCGA-Q3-AA2A-01A-11D-A377-08	KRIT1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000253910.1	1	0	1	100	225	0	69	0	2.280106e-01	0	3	0	69	2		0	0	0	0	0	2	1	1.000000	100	225	0	68	2		0	0	0	0	69	2	-8.826397	1	1	0	0		1	0	0	0	2.037488	0	0.540000	1.930000	0.540000	0.990000	9.500000e-01	1.000000	1.000000	0.997467	0.990000	1	9.900000e-01	1.000000
CSMD1	64478	broad.mit.edu	37	8	2820823	2820823	+	Silent	SNP	G	G	A			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr8:2820823G>A	ENST00000520002.1	-	61	9933	c.9378C>T	c.(9376-9378)gaC>gaT	p.D3126D	CSMD1_ENST00000542608.1_Silent_p.D2948D|CSMD1_ENST00000602557.1_Silent_p.D3126D|CSMD1_ENST00000537824.1_Silent_p.D3125D|CSMD1_ENST00000400186.3_Silent_p.D2949D|CSMD1_ENST00000602723.1_Silent_p.D2949D			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1			25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)			GCTGGTAACCGTCCATGCAGC	0.562000																								0							SO:0001819	synonymous_variant			ENST00000520002.1	0	1	hg19		.	.	.	.	.	.	.	.	.	.	G	0.254	-1.004364	0.02112	.	.	ENSG00000183117	ENST00000335551	.	.	.	5.69	-2.77	0.05877	.	.	.	.	.	T	0.36552	0.0971	.	.	.	0.80722	D	1	.	.	.	.	.	.	T	0.34354	-0.9832	4	.	.	.	.	0.4751	0.00538	0.3679:0.2388:0.1773:0.216	.	.	.	.	W	2543	.	.	R	-	1	2	CSMD1	2808230	0.000000	0.05858	0.047000	0.18901	0.110000	0.19582	-1.200000	0.03029	-0.162000	0.10964	-0.136000	0.14681	CGG		TCGA-Q3-AA2A-01A-11D-A377-08	CSMD1-001	KNOWN	basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000374500.2	0	0	0	5	589	0	121		0	0	0	0	121	2		0	0	0	0	0	2	1	0.934951	5	579	0	121	2		0	0	0	0	121	2	-2.498943	0	1	120858	2	37	1	0	0	0	2.039547	0	0.540000	1.930000	0.540000	0.030000	0	0.070000	0.040000	0.036638	0.030000	0	1.000000e-02	0.050000
SLCO5A1	81796	broad.mit.edu	37	8	70744099	70744099	+	Silent	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr8:70744099C>T	ENST00000260126.4	-	2	1516	c.810G>A	c.(808-810)gcG>gcA	p.A270A	RP11-159H10.3_ENST00000501104.2_RNA|RP11-159H10.3_ENST00000528800.2_RNA|SLCO5A1_ENST00000524945.1_Silent_p.A270A|SLCO5A1_ENST00000530307.1_Silent_p.A270A|SLCO5A1_ENST00000528658.1_5'UTR|RP11-159H10.3_ENST00000533300.1_RNA	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	p.A270A(1)		53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)		TGAGAATCTGCGCGCAAATGA	0.502000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000260126.4	0	1	hg19	CCDS6205.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	SLCO5A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000381990.3	0	0	0	7	397	0	88		0	0	0	0	88	2		0	0	0	0	0	2	1	0.979940	7	394	0	87	2		0	0	0	0	88	2	-2.509814	1	1	0	0		1	0	0	0	2.035975	0	0.540000	1.930000	0.540000	0.060000	2.000000e-02	0.130000	0.060000	0.072825	0.060000	0	4.000000e-02	0.100000
C9orf24	84688	broad.mit.edu	37	9	34381380	34381380	+	Silent	SNP	C	C	T			TCGA-Q3-AA2A-01A-11D-A377-08	TCGA-Q3-AA2A-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43b83885-061c-45d6-b8eb-11650ad2db96	977811bf-1722-4d2b-9347-69902f08c59a	g.chr9:34381380C>T	ENST00000297623.2	-	4	657	c.459G>A	c.(457-459)cgG>cgA	p.R153R	C9orf24_ENST00000379124.1_Silent_p.R18R|C9orf24_ENST00000379133.3_Silent_p.R18R|C9orf24_ENST00000379126.3_Silent_p.R18R|C9orf24_ENST00000379127.1_Silent_p.R18R|C9orf24_ENST00000481295.1_5'Flank	NM_032596.3	NP_115985.2	Q8NCR6	SMRP1_HUMAN	chromosome 9 open reading frame 24			5			LUSC - Lung squamous cell carcinoma(29;0.0107)		AGGCATTGAGCCGCTCCGGCC	0.612000																								0							SO:0001819	synonymous_variant			ENST00000297623.2	0	1	hg19	CCDS6554.1																																																																																				TCGA-Q3-AA2A-01A-11D-A377-08	C9orf24-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000001098.3	0	0	0	5	560	1	123		0	0	0	1	123	2		0	0	0	0	0	2	0	0.010500	5	544	1	122	16		0	0	0	1	123	2	-1.964080	0	1	0	0		1	1	2	3	2.113925	0	0.540000	1.930000	0.548533	0.030000	0	1.000000	0.040000	0.092904	0.030000	0	1.000000e-02	0.060000