Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
CGNL1	84952	broad.mit.edu	37	15	57823890	57823890	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	-	C	C		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr15:57823890delC	ENST00000281282.5	+	14	3282	c.3204delC	c.(3202-3204)gacfs	p.D1068fs	CTD-2515H24.4_ENST00000566990.1_lincRNA	NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1			60					CTTCTTAGGACAAGGTGTCTC	0.448000																								0							SO:0001589	frameshift_variant			ENST00000281282.5	1	1	hg19	CCDS10161.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	CGNL1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255482.2	1	0	0	167	804	0	138	0	9.926001e-01	1	37	0	138	2	0	0	0	0	0	0		1	1.000000	165	796	0	136	2								-20.000000	1	1	0	0		1	2	2	4	2.323645	1	0.370000	2.950000	0.540146	0.990000	0.990000	1.000000	1.000000	0.999986	0.990000	1	9.900000e-01	1
TBC1D12	23232	broad.mit.edu	37	10	96269882	96269882	+	Silent	SNP	A	A	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr10:96269882A>G	ENST00000225235.4	+	8	1745	c.1635A>G	c.(1633-1635)gaA>gaG	p.E545E	TBC1D12_ENST00000485048.1_3'UTR	NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12			20		Colorectal(252;0.0429)			CCAGTCTGGAATTAATTAAGT	0.353000																								0							SO:0001819	synonymous_variant			ENST00000225235.4	1	1	hg19	CCDS41553.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	TBC1D12-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000049482.2	1	0	1	69	334	0	40	1	8.588797e-01	3	16	0	40	2		0	0	0	0	0	2	1	1.000000	68	330	0	40	2								-20.000000	1	1	0	0		1	1	2	3	2.038979	1	0.370000	2.950000	0.468354	0.990000	0.870000	1.000000	1.000000	0.987911	0.990000	1	9.700000e-01	1
OR4D5	219875	broad.mit.edu	37	11	123810383	123810383	+	Silent	SNP	T	T	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr11:123810383T>C	ENST00000307033.2	+	1	134	c.60T>C	c.(58-60)gtT>gtC	p.V20V		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5			41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)			TCTCTCAGGTTTGGGAGCTTC	0.443000																								0							SO:0001819	synonymous_variant			ENST00000307033.2	1	1	hg19	CCDS31699.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	OR4D5-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000387263.1	1	0	0	44	494	0	97		0	0	0	0	97	2		0	0	0	0	0	2	1	1.000000	44	488	0	97	2								-12.187060	1	1	0	0		1	1	2	3	2.025181	1	0.370000	2.950000	0.468354	0.520000	0.380000	0.680000	0.520000	0.532660	0.520000	0	4.500000e-01	6.100000e-01
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	T	A	rs17851045		TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr12:25380275T>A	ENST00000256078.4	-	3	246	c.183A>T	c.(181-183)caA>caT	p.Q61H	KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.Q61H(153)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		TGTACTCCTCTTGACCTGCTG	0.423000	Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	153	Substitution - Missense(153)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	1	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	T	22.100000	4.243092	0.799120	.	.	ENSG00000133703	ENST00000311936;ENST00000256078	D;D	0.84146	-1.81;-1.81	5.770000	5.770000	0.911460	Small GTP-binding protein domain (1);	0.049057	0.85682	D	0.000000	D	0.87265	0.6134	M	0.91140	3.18	0.807220	D	1.000000	B;B	0.33413	0.411;0.09	B;B	0.32724	0.092;0.151	D	0.87829	0.2643	10	0.72032	D	0.01	.	9.983600	0.418280	0.0:0.0752:0.0:0.9248	rs17851045	61;61	P01116-2;P01116	.;RASK_HUMAN	H	61	ENSP00000308495:Q61H;ENSP00000256078:Q61H	ENSP00000256078:Q61H	Q	-	3	2	KRAS	25271542	1	0.714170	1	0.803570	9.990000e-01	0.989320	2.240000	0.430880	2.326000	0.789060	0.533000	0.621200	CAA		TCGA-HZ-7922-01A-11D-2154-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	1	185	285	0	47	1	1	56	64	0	47	2	1	1	513	1006	1	864	8	1	1.000000	184	284	0	47	2								-20.000000	1	1	0	0		1						0.370000	2.950000									0	0
ARID2	196528	broad.mit.edu	37	12	46231283	46231283	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr12:46231283A>G	ENST00000334344.6	+	10	1295	c.1123A>G	c.(1123-1125)Atg>Gtg	p.M375V	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Missense_Mutation_p.M226V|ARID2_ENST00000444670.1_Missense_Mutation_p.M4V	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)			116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)		TTTTTCAGGCATGGAAATTTT	0.308000			N, S, F		hepatocellular carcinoma										Rec	yes		12	12q12	196528	AT rich interactive domain 2		E	0							SO:0001583	missense			ENST00000334344.6	1	1	hg19	CCDS31783.1	.	.	.	.	.	.	.	.	.	.	A	16.230000	3.065763	0.555390	.	.	ENSG00000189079	ENST00000334344;ENST00000422737;ENST00000444670	T;T	0.43294	0.95;0.95	5.330000	5.330000	0.759180	.	0.000000	0.85682	D	0.000000	T	0.60209	0.2251	L	0.59436	1.845	0.807220	D	1.000000	P;P;P	0.52577	0.954;0.799;0.865	D;P;P	0.66351	0.943;0.468;0.824	T	0.63233	-0.6683	10	0.72032	D	0.01	-9.3805	15.300600	0.739490	1.0:0.0:0.0:0.0	.	375;226;375	Q68CP9-3;F8WCU9;Q68CP9	.;.;ARID2_HUMAN	V	375;226;4	ENSP00000335044:M375V;ENSP00000415650:M226V	ENSP00000335044:M375V	M	+	1	0	ARID2	44517550	1	0.714170	1	0.803570	5.110000e-01	0.341040	9.339000	0.967970	2.011000	0.590260	0.260000	0.189580	ATG		TCGA-HZ-7922-01A-11D-2154-08	ARID2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000318380.2	1	0	1	149	535	0	80	1	9.901846e-01	6	22	0	80	2		0	0	0	0	0	2	1	1.000000	149	529	0	80	2								-20.000000	1	1	0	0		1	2	2	4	2.262849	1	0.370000	2.950000	0.527382	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
KCNA6	3742	broad.mit.edu	37	12	4920010	4920010	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr12:4920010C>T	ENST00000280684.3	+	1	1669	c.803C>T	c.(802-804)aCg>aTg	p.T268M	RP11-234B24.4_ENST00000542988.1_lincRNA|KCNA6_ENST00000433855.1_Missense_Mutation_p.T268M			P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6			49				Dalfampridine(DB06637)	CTGGTGGAGACGCTGTGCATT	0.562000										HNSCC(72;0.22)														0							SO:0001583	missense			ENST00000280684.3	1	1	hg19	CCDS8534.1	.	.	.	.	.	.	.	.	.	.	C	18.990000	3.738897	0.693040	.	.	ENSG00000151079	ENST00000433855;ENST00000280684	D;D	0.98400	-4.91;-4.91	5.280000	4.400000	0.530420	Ion transport (1);	0.000000	0.85682	D	0.000000	D	0.98798	0.9595	M	0.83774	2.66	0.584320	D	0.999998	D	0.89917	1.0	D	0.80764	0.994	D	0.99694	1.1002	10	0.87932	D	0	.	13.185200	0.596770	0.0:0.924:0.0:0.076	.	268	P17658	KCNA6_HUMAN	M	268	ENSP00000408321:T268M;ENSP00000280684:T268M	ENSP00000280684:T268M	T	+	2	0	KCNA6	4790271	1	0.714170	9.250000e-01	0.367890	9.840000e-01	0.730920	7.592000	0.826760	1.469000	0.480830	0.655000	0.942530	ACG		TCGA-HZ-7922-01A-11D-2154-08	KCNA6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000398909.1	0	0	0	18	563	0	90	0	0	0	1	0	90	2		0	0	0	0	0	2	1	0.999981	16	561	0	90	2								-3.731561	1	1	0	0		1	2	2	4	2.236184	1	0.370000	2.950000	0.522076	0.230000	0.130000	1.000000	0.220000	0.317579	0.230000	0	1.700000e-01	3.200000e-01
SPRYD3	84926	broad.mit.edu	37	12	53459657	53459657	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr12:53459657C>T	ENST00000301463.4	-	11	1374	c.1288G>A	c.(1288-1290)Ggg>Agg	p.G430R	SPRYD3_ENST00000547837.1_Missense_Mutation_p.G467R	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	p.G430W(1)		17					ACTTTCTCCCCGCAGCTCAGC	0.567000											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)												1	Substitution - Missense(1)						SO:0001583	missense			ENST00000301463.4	1	1	hg19	CCDS8845.1	.	.	.	.	.	.	.	.	.	.	C	24.400000	4.526414	0.856000	.	.	ENSG00000167778	ENST00000301463;ENST00000547837	T;T	0.76839	-1.05;-1.05	5.290000	5.290000	0.746850	Concanavalin A-like lectin/glucanase (1);SPla/RYanodine receptor subgroup (1);	0.063055	0.64402	D	0.000008	D	0.82912	0.5140	L	0.49778	1.585	0.584320	D	0.999999	D	0.69078	0.997	P	0.59056	0.851	T	0.83279	-0.0039	10	0.51188	T	0.08	.	16.809800	0.857160	0.0:1.0:0.0:0.0	.	430	Q8NCJ5	SPRY3_HUMAN	R	430;467	ENSP00000301463:G430R;ENSP00000449452:G467R	ENSP00000301463:G430R	G	-	1	0	SPRYD3	51745924	1	0.714170	9.990000e-01	0.593770	9.260000e-01	0.560500	5.386000	0.662380	2.642000	0.896230	0.563000	0.778840	GGG		TCGA-HZ-7922-01A-11D-2154-08	SPRYD3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000407264.1	1	0	1	136	452	0	73	1	1	59	201	0	73	2		0	0	0	0	0	2	1	1.000000	133	444	0	73	2								-3.678004	1	1	0	0		1	2	2	4	2.238683	1	0.370000	2.950000	0.522076	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
RAB3IP	117177	broad.mit.edu	37	12	70209146	70209146	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr12:70209146G>A	ENST00000247833.7	+	11	1679	c.1303G>A	c.(1303-1305)Gat>Aat	p.D435N	RAB3IP_ENST00000483530.2_3'UTR|RAB3IP_ENST00000553099.1_Missense_Mutation_p.D229N|RAB3IP_ENST00000550536.1_Missense_Mutation_p.D451N|RAB3IP_ENST00000550847.1_Missense_Mutation_p.D142N|RAB3IP_ENST00000362025.5_3'UTR|RAB3IP_ENST00000551641.1_Missense_Mutation_p.D229N|RAB3IP_ENST00000325555.9_Missense_Mutation_p.D229N|AC025263.3_ENST00000550437.1_Intron					RAB3A interacting protein			22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)		TTGTATAGTTGATCAGATGTT	0.363000																								0							SO:0001583	missense			ENST00000247833.7	1	1	hg19	CCDS8995.1	.	.	.	.	.	.	.	.	.	.	G	22.100000	4.239138	0.798000	.	.	ENSG00000127328	ENST00000247833;ENST00000325555;ENST00000550536;ENST00000551641;ENST00000553099;ENST00000550847	T;T;T;T;T;T	0.40756	1.02;1.02;1.02;1.02;1.02;1.02	5.650000	5.650000	0.869990	.	0.046748	0.85682	D	0.000000	T	0.54598	0.1868	L	0.29908	0.895	0.807220	D	1.000000	D	0.69078	0.997	D	0.77004	0.989	T	0.48592	-0.9022	10	0.34782	T	0.22	.	19.730800	0.961810	0.0:0.0:1.0:0.0	.	451	Q96QF0	RAB3I_HUMAN	N	435;229;451;229;229;142	ENSP00000247833:D435N;ENSP00000323349:D229N;ENSP00000447300:D451N;ENSP00000448773:D229N;ENSP00000448027:D229N;ENSP00000448102:D142N	ENSP00000247833:D435N	D	+	1	0	RAB3IP	68495413	1	0.714170	1	0.803570	9.600000e-01	0.627990	9.476000	0.978230	2.674000	0.910120	0.591000	0.815410	GAT		TCGA-HZ-7922-01A-11D-2154-08	RAB3IP-003	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000280671.2	1	0	1	96	420	0	66	0	9.701868e-01	0	27	0	66	2		0	0	0	0	0	2	1	1.000000	95	418	0	66	2								-20.000000	1	1	0	0		1	2	2	4	2.238890	1	0.370000	2.950000	0.531285	0.990000	0.990000	1.000000	1.000000	0.999969	0.990000	1	9.900000e-01	1
GTF3A	2971	broad.mit.edu	37	13	28001293	28001293	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr13:28001293G>T	ENST00000381140.4	+	2	460	c.266G>T	c.(265-267)cGc>cTc	p.R89L	GTF3A_ENST00000470606.1_3'UTR	NM_002097.2	NP_002088	Q92664	TF3A_HUMAN	general transcription factor IIIA			2		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)		CATCTGAGCCGCCACATTCTG	0.453000																								0							SO:0001583	missense			ENST00000381140.4	1	1	hg19	CCDS45019.1	.	.	.	.	.	.	.	.	.	.	G	22.800000	4.343156	0.820220	.	.	ENSG00000122034	ENST00000381140	D	0.96232	-3.95	5.050000	5.050000	0.679360	Zinc finger, C2H2-like (1);Zinc finger, C2H2 (3);Zinc finger, C2H2-type/integrase, DNA-binding (1);	0.060233	0.64402	D	0.000003	D	0.96580	0.8884	L	0.38531	1.155	0.476590	D	0.999486	D	0.89917	1.0	D	0.87578	0.998	D	0.95247	0.8356	9	0.23891	T	0.37	-30.5797	16.945600	0.862290	0.0:0.0:1.0:0.0	.	89	Q92664	TF3A_HUMAN	L	89	ENSP00000370532:R89L	ENSP00000370532:R89L	R	+	2	0	GTF3A	26899293	1	0.714170	1	0.803570	5.980000e-01	0.368460	6.197000	0.721000	2.495000	0.841800	0.655000	0.942530	CGC		TCGA-HZ-7922-01A-11D-2154-08	GTF3A-001	NOVEL	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000044281.2	1	0	1	27	77	0	16	1	1	94	236	0	16	2		0	0	0	0	0	2	1	1.000000	27	75	0	16	2								-4.540687	1	1	0	0		1	2	2	4	2.330876	1	0.370000	2.950000	0.540146	0.990000	0.990000	1.000000	1.000000	0.999983	0.990000	1	9.900000e-01	1
PCDH9	5101	broad.mit.edu	37	13	67802227	67802227	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr13:67802227C>A	ENST00000377865.2	-	1	480	c.346G>T	c.(346-348)Gtg>Ttg	p.V116L	PCDH9_ENST00000456367.1_Missense_Mutation_p.V116L|PCDH9_ENST00000544246.1_Missense_Mutation_p.V116L|PCDH9_ENST00000328454.5_Missense_Mutation_p.V116L|PCDH9_ENST00000377861.3_Missense_Mutation_p.V116L			Q9HC56	PCDH9_HUMAN	protocadherin 9			103		Hepatocellular(98;0.0906)|Breast(118;0.107)			GGGAGGATCACCACCTCAAGT	0.408000																								0							SO:0001583	missense			ENST00000377865.2	1	1	hg19	CCDS9444.1	.	.	.	.	.	.	.	.	.	.	C	13.510000	2.257728	0.398960	.	.	ENSG00000184226	ENST00000544246;ENST00000377865;ENST00000456367;ENST00000328454;ENST00000377861	T;T;T;T;T	0.26373	1.74;1.74;1.74;1.74;1.74	5.940000	5.940000	0.961940	Cadherin, N-terminal (1);Cadherin (3);	0.000000	0.85682	D	0.000000	T	0.31734	0.0806	L	0.28504	0.86	0.807220	D	1.000000	B;P;P;P	0.46784	0.043;0.596;0.859;0.884	B;B;P;P	0.49922	0.048;0.324;0.492;0.626	T	0.00472	-1.1719	10	0.28530	T	0.3	.	20.359100	0.988490	0.0:1.0:0.0:0.0	.	116;116;116;116	B7ZM79;Q5VT82;Q9HC56-2;Q9HC56	.;.;.;PCDH9_HUMAN	L	116	ENSP00000442186:V116L;ENSP00000367096:V116L;ENSP00000401699:V116L;ENSP00000332060:V116L;ENSP00000367092:V116L	ENSP00000332060:V116L	V	-	1	0	PCDH9	66700228	1	0.714170	1	0.803570	9.950000e-01	0.863560	7.818000	0.864160	2.816000	0.969490	0.561000	0.740990	GTG		TCGA-HZ-7922-01A-11D-2154-08	PCDH9-003	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000276387.1	1	0	0	52	544	0	68	0	6.585001e-02	0	5	0	68	2		0	0	0	0	0	2	1	1.000000	51	537	0	68	2								-14.507670	1	1	0	0		1	2	2	4	2.330876	1	0.370000	2.950000	0.540146	0.640000	0.480000	0.820000	0.640000	0.655403	0.640000	0	5.600000e-01	7.400000e-01
PCDH9	5101	broad.mit.edu	37	13	67802228	67802228	+	Silent	SNP	C	C	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr13:67802228C>A	ENST00000377865.2	-	1	479	c.345G>T	c.(343-345)gtG>gtT	p.V115V	PCDH9_ENST00000456367.1_Silent_p.V115V|PCDH9_ENST00000544246.1_Silent_p.V115V|PCDH9_ENST00000328454.5_Silent_p.V115V|PCDH9_ENST00000377861.3_Silent_p.V115V			Q9HC56	PCDH9_HUMAN	protocadherin 9			103		Hepatocellular(98;0.0906)|Breast(118;0.107)			GGAGGATCACCACCTCAAGTT	0.413000																								0							SO:0001819	synonymous_variant			ENST00000377865.2	0	1	hg19	CCDS9444.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	PCDH9-003	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000276387.1	0	0	0	52	551	1	67	0	6.486879e-02	0	5	1	67	2		0	0	0	0	0	2	1	0.999100	51	544	1	67	26								-13.936920	1	1	0	0		1	2	2	4	2.330876	1	0.370000	2.950000	0.540146	0.630000	0.480000	0.810000	0.640000	0.647833	0.630000	0	5.500000e-01	7.300000e-01
C14orf39	317761	broad.mit.edu	37	14	60945081	60945081	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr14:60945081C>T	ENST00000321731.3	-	5	419	c.260G>A	c.(259-261)cGt>cAt	p.R87H		NM_174978.2	NP_777638	Q8N1H7	S6OS1_HUMAN	chromosome 14 open reading frame 39			30					TTCATGTTTACGAAAAACATC	0.264000																								0							SO:0001583	missense			ENST00000321731.3	1	1	hg19	CCDS9746.1	.	.	.	.	.	.	.	.	.	.	C	0.008000	-1.886518	0.005270	.	.	ENSG00000179008	ENST00000321731;ENST00000555476;ENST00000556799	T;T	0.41400	2.02;1.0	5.560000	1.870000	0.254900	.	0.424204	0.24945	N	0.034343	T	0.11580	0.0282	N	0.01109	-1.01	0.195750	N	0.999969	B	0.06786	0.001	B	0.01281	0.0	T	0.36720	-0.9736	10	0.02654	T	1	-3.7283	8.519600	0.332680	0.0:0.2298:0.0:0.7702	.	87	Q8N1H7	S6OS1_HUMAN	H	87;58;87	ENSP00000324920:R87H;ENSP00000451665:R58H	ENSP00000324920:R87H	R	-	2	0	C14orf39	60014834	9.950000e-01	0.382120	9.990000e-01	0.593770	3.000000e-03	0.035180	0.079000	0.147820	0.142000	0.189010	-1.969000	0.004660	CGT		TCGA-HZ-7922-01A-11D-2154-08	C14orf39-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000276948.1	1	0	1	41	159	0	36		0	0	0	0	36	2		0	0	0	0	0	2	1	1.000000	41	155	0	36	2								-20.000000	1	1	121372	7	35	1	2	2	4	2.298994	1	0.370000	2.950000	0.535124	0.990000	0.990000	1.000000	1.000000	0.999835	0.990000	1	9.900000e-01	1
MGRN1	23295	broad.mit.edu	37	16	4702743	4702743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr16:4702743G>T	ENST00000399577.5	+	4	454	c.361G>T	c.(361-363)Gag>Tag	p.E121*	MGRN1_ENST00000415496.1_Nonsense_Mutation_p.E121*|MGRN1_ENST00000588994.1_Nonsense_Mutation_p.E121*|MGRN1_ENST00000262370.7_Nonsense_Mutation_p.E121*|MGRN1_ENST00000586183.1_Nonsense_Mutation_p.E121*	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase			18					CTACAGCCTGGAGTTCACCTT	0.662000																								0							SO:0001587	stop_gained			ENST00000399577.5	0	1	hg19	CCDS45402.1	.	.	.	.	.	.	.	.	.	.	G	25.500000	4.645878	0.879580	.	.	ENSG00000102858	ENST00000262370;ENST00000399577;ENST00000415496;ENST00000536343	.	.	.	5.400000	5.400000	0.781640	.	0.000000	0.85682	D	0.000000	.	.	.	.	.	.	0.807220	A	1.000000	.	.	.	.	.	.	.	.	.	.	0.56958	D	0.05	-33.4513	17.757900	0.884550	0.0:0.0:1.0:0.0	.	.	.	.	X	121	.	ENSP00000262370:E121X	E	+	1	0	MGRN1	4642744	1	0.714170	1	0.803570	8.000000e-02	0.175280	9.813000	0.992860	2.537000	0.855490	0.561000	0.740990	GAG		TCGA-HZ-7922-01A-11D-2154-08	MGRN1-004	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000432060.2	1	0	1	35	70	0	21	1	1	12	65	0	21	2		0	0	0	0	0	2	1	1.000000	33	68	0	21	2								-20.000000	1	1	0	0		1	1	2	3	2.008769	1	0.370000	2.950000	0.465014	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
RLTPR	146206	broad.mit.edu	37	16	67682073	67682073	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr16:67682073C>T	ENST00000334583.6	+	14	1518	c.1190C>T	c.(1189-1191)gCg>gTg	p.A397V	RLTPR_ENST00000545661.1_Intron	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing			18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)			ACCGGCAGGGCGGACTGGAGG	0.692000																								0							SO:0001583	missense			ENST00000334583.6	1	1	hg19	CCDS45513.1	.	.	.	.	.	.	.	.	.	.	C	7.612000	0.675061	0.148410	.	.	ENSG00000159753	ENST00000334583	T	0.13307	2.6	3.450000	-2.700000	0.060040	.	5.763050	0.00786	N	0.001302	T	0.07098	0.0180	N	0.14661	0.345	0.093100	N	1.000000	B	0.02656	0.0	B	0.01281	0.0	T	0.24404	-1.0161	10	0.21014	T	0.42	-19.0545	2.467900	0.045570	0.3865:0.2967:0.0:0.3169	.	397	Q6F5E8	LR16C_HUMAN	V	397	ENSP00000334958:A397V	ENSP00000334958:A397V	A	+	2	0	RLTPR	66239574	0	0.058580	0	0.037020	1.830000e-01	0.232600	-2.040000	0.014160	-0.255000	0.094860	0.462000	0.415740	GCG		TCGA-HZ-7922-01A-11D-2154-08	RLTPR-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000467858.1	1	0	0	33	62	0	19		0	0	0	0	19	2		0	0	0	0	0	2	1	1.000000	33	62	0	19	2								-20.000000	1	1	0	0		1	1	2	3	2.013105	1	0.370000	2.950000	0.468354	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
PSKH1	5681	broad.mit.edu	37	16	67961230	67961230	+	Silent	SNP	C	C	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr16:67961230C>G	ENST00000291041.5	+	3	1130	c.960C>G	c.(958-960)ccC>ccG	p.P320P		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1			12		Ovarian(137;0.192)			GTCTCTAGCCCTGGCCTAGTG	0.587000																								0							SO:0001819	synonymous_variant			ENST00000291041.5	1	1	hg19	CCDS10851.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	PSKH1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000268882.3	1	0	1	167	311	0	78	1	1	18	50	0	78	2		0	0	0	0	0	2	1	1.000000	167	305	0	78	2								-16.713520	1	1	0	0		1	1	2	3	2.013105	1	0.370000	2.950000	0.468354	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
NCOR1	9611	broad.mit.edu	37	17	16089977	16089977	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr17:16089977A>G	ENST00000268712.3	-	3	390	c.133T>C	c.(133-135)Tcc>Ccc	p.S45P	NCOR1_ENST00000395848.1_Intron|NCOR1_ENST00000395851.1_Missense_Mutation_p.S45P	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1			107					AGATGAGAGGAACGATAATCA	0.403000																								0							SO:0001583	missense			ENST00000268712.3	1	1	hg19	CCDS11175.1	.	.	.	.	.	.	.	.	.	.	A	11.660000	1.703488	0.302320	.	.	ENSG00000141027	ENST00000268712;ENST00000395851;ENST00000458113;ENST00000411510;ENST00000436828;ENST00000430577	T;T	0.47528	0.84;1.43	5.780000	4.700000	0.593000	.	0.000000	0.85682	D	0.000000	T	0.57257	0.2041	L	0.46157	1.445	0.807220	D	1.000000	B;P;P;P;D;D	0.69078	0.396;0.94;0.528;0.94;0.995;0.997	B;B;B;B;P;D	0.63793	0.135;0.441;0.244;0.441;0.829;0.918	T	0.56080	-0.8038	10	0.48119	T	0.1	-1.5681	11.127800	0.483280	0.928:0.0:0.072:0.0	.	45;45;45;45;45;45	E7EU93;E7EV02;Q3B773;E7EW50;O75376;O75376-2	.;.;.;.;NCOR1_HUMAN;.	P	45	ENSP00000268712:S45P;ENSP00000379192:S45P	ENSP00000268712:S45P	S	-	1	0	NCOR1	16030702	1	0.714170	9.690000e-01	0.413650	7.770000e-01	0.439750	4.544000	0.606910	1.006000	0.392110	0.460000	0.390300	TCC		TCGA-HZ-7922-01A-11D-2154-08	NCOR1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000131751.5	1	0	1	40	267	0	39	1	9.970874e-01	5	57	0	39	2		0	0	0	0	0	2	1	1.000000	40	264	0	39	2								-20.000000	1	1	0	0		1	0	2	2	1.724001	1	0.370000	2.950000	0.370000	0.700000	0.510000	0.910000	0.700000	0.713033	0.700000	0	6.000000e-01	8.100000e-01
DNAI2	64446	broad.mit.edu	37	17	72308199	72308199	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr17:72308199C>T	ENST00000311014.6	+	12	1619	c.1552C>T	c.(1552-1554)Cgg>Tgg	p.R518W	DNAI2_ENST00000579490.1_Missense_Mutation_p.R575W|RP11-647F2.2_ENST00000585167.1_RNA|DNAI2_ENST00000307504.5_Missense_Mutation_p.R375W|DNAI2_ENST00000446837.2_Missense_Mutation_p.R518W|DNAI2_ENST00000582036.1_Missense_Mutation_p.R506W			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2			39					CCGGGAGATGCGGCTGAAGGA	0.657000									Kartagener syndrome															0							SO:0001583	missense	Familial Cancer Database	Ciliary Dyskinesia, Primary (CILD1 - CILD13), Immotile Cilia Syndrome	ENST00000311014.6	0	1	hg19	CCDS11697.1	.	.	.	.	.	.	.	.	.	.	C	21.800000	4.195638	0.789020	.	.	ENSG00000171595	ENST00000311014;ENST00000307504;ENST00000446837	T;T;T	0.34859	1.34;1.34;1.34	4.620000	3.640000	0.417300	.	0.058074	0.64402	D	0.000001	T	0.64527	0.2606	M	0.90705	3.14	0.584320	D	0.999993	D	0.89917	1.0	D	0.79784	0.993	T	0.71361	-0.4616	10	0.87932	D	0	-34.1547	12.000700	0.532280	0.315:0.685:0.0:0.0	.	518	Q9GZS0	DNAI2_HUMAN	W	518;375;518	ENSP00000308312:R518W;ENSP00000302929:R375W;ENSP00000400252:R518W	ENSP00000302929:R375W	R	+	1	2	DNAI2	69819794	1	0.714170	1	0.803570	9.820000e-01	0.717510	2.401000	0.445130	0.950000	0.377430	0.485000	0.478350	CGG		TCGA-HZ-7922-01A-11D-2154-08	DNAI2-001	KNOWN	NMD_exception|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000442537.1	0	0	0	5	202	0	44		0	0	0	0	44	2		0	0	0	0	0	2	1	0.936704	5	200	0	44	2								-3.004511	1	1	121396	11	40	1	0	2	2	1.713689	1	0.370000	2.950000	0.370000	0.140000	0.050000	0.280000	0.130000	0.153893	0.140000	0	8.000000e-02	2.100000e-01
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr17:7578263G>A	ENST00000269305.4	-	6	775	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*|TP53_ENST00000420246.2_Nonsense_Mutation_p.R196*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		Acetylsalicylic acid(DB00945)	CCTTCCACTCGGATAAGATGC	0.552000		111	Mis, N, F		breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			Pancreas(47;798 1329 9957 10801)	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		L, E, M, O	232	Substitution - Nonsense(195)|Deletion - Frameshift(11)|Whole gene deletion(8)|Deletion - In frame(5)|Complex - deletion inframe(5)|Unknown(5)|Substitution - coding silent(2)|Complex - frameshift(1)	GRCh37	CM941329	TP53	M		SO:0001587	stop_gained	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	ENST00000269305.4	0	1	hg19	CCDS11118.1	.	.	.	.	.	.	.	.	.	.	G	14.020000	2.409843	0.427150	.	.	ENSG00000141510	ENST00000413465;ENST00000359597;ENST00000269305;ENST00000455263;ENST00000420246;ENST00000445888;ENST00000396473;ENST00000545858;ENST00000509690;ENST00000514944;ENST00000414315	.	.	.	5.410000	4.440000	0.537900	.	0.000000	0.85682	D	0.000000	.	.	.	.	.	.	0.807220	A	1.000000	.	.	.	.	.	.	.	.	.	.	0.02654	T	1	-19.9531	12.304600	0.548950	0.0827:0.0:0.9173:0.0	.	.	.	.	X	196;196;196;196;196;196;185;103;64;103;64	.	ENSP00000269305:R196X	R	-	1	2	TP53	7518988	1	0.714170	9.970000e-01	0.539660	2.300000e-02	0.107830	2.166000	0.424060	1.427000	0.472760	-0.140000	0.142260	CGA		TCGA-HZ-7922-01A-11D-2154-08	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367397.1	1	0	1	83	129	0	42	0	9.999989e-01	1	36	0	42	2	1	1	458	825	2	1024	9	1	1.000000	83	129	0	41	2								-13.031110	1	1	121412	1	40	1	0	2	2	1.724001	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
KDM6B	23135	broad.mit.edu	37	17	7752472	7752472	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr17:7752472G>A	ENST00000448097.2	+	11	3197	c.2866G>A	c.(2866-2868)Gca>Aca	p.A956T	KDM6B_ENST00000254846.5_Missense_Mutation_p.A956T			O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B			37					GCTGCCCCCCGCACAGGCCAA	0.692000																								0							SO:0001583	missense			ENST00000448097.2	0	1	hg19		.	.	.	.	.	.	.	.	.	.	G	7.985000	0.752026	0.157780	.	.	ENSG00000132510	ENST00000254846;ENST00000448097	T;T	0.34072	1.38;1.39	4.390000	-1.750000	0.080310	.	1.071470	0.07336	N	0.879937	T	0.14013	0.0339	N	0.14661	0.345	0.093100	N	1.000000	B;B	0.02656	0.0;0.0	B;B	0.04013	0.0;0.001	T	0.26467	-1.0102	10	0.05833	T	0.94	0.0123	0.783700	0.010450	0.2956:0.1624:0.3758:0.1662	.	956;956	O15054;O15054-1	KDM6B_HUMAN;.	T	956	ENSP00000254846:A956T;ENSP00000412513:A956T	ENSP00000254846:A956T	A	+	1	0	KDM6B	7693197	0	0.058580	0	0.037020	8.570000e-01	0.488990	-0.879000	0.041880	-0.031000	0.137810	-0.448000	0.055910	GCA		TCGA-HZ-7922-01A-11D-2154-08	KDM6B-002	KNOWN	basic	protein_coding	protein_coding	OTTHUMT00000440248.1	0	0	0	4	77	0	29	0	2.314682e-01	0	15	0	29	2		0	0	0	0	0	2	1	0.889197	4	76	0	29	2								-7.630378	1	1	119674	3	34	1	0	2	2	1.724001	1	0.370000	2.950000	0.370000	0.290000	0.100000	0.610000	0.260000	0.318837	0.290000	0	1.700000e-01	4.500000e-01
CAPNS1	826	broad.mit.edu	37	19	36633201	36633201	+	Splice_Site	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:36633201G>A	ENST00000246533.3	+	3	807		c.e3-1		CAPNS1_ENST00000588780.1_Splice_Site|AD001527.7_ENST00000604228.1_RNA|CAPNS1_ENST00000587718.1_Splice_Site|CAPNS1_ENST00000590874.1_Splice_Site|CAPNS1_ENST00000589146.1_Intron|CAPNS1_ENST00000588815.1_Splice_Site	NM_001003962.1|NM_001749.2	NP_001003962.1|NP_001740.1	P04632	CPNS1_HUMAN	calpain, small subunit 1			5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)		TCTCTTCGCAGCGAGGCGGCT	0.652000													Esophageal Squamous(129;1541 1691 5780 18353 34150)											0							SO:0001630	splice_region_variant			ENST00000246533.3	1	1	hg19	CCDS12489.1	.	.	.	.	.	.	.	.	.	.	G	15.930000	2.978756	0.537200	.	.	ENSG00000126247	ENST00000246533	.	.	.	5.170000	5.170000	0.711590	.	.	.	.	.	.	.	.	.	.	.	0.807220	D	1.000000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	14.522500	0.678590	0.0:0.0:1.0:0.0	.	.	.	.	.	-1	.	.	.	+	.	.	CAPNS1	41325041	1	0.714170	9.680000e-01	0.411970	5.220000e-01	0.344380	5.289000	0.656560	2.564000	0.864990	0.561000	0.740990	.		TCGA-HZ-7922-01A-11D-2154-08	CAPNS1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000457411.2	1	0	1	165	444	0	88	1	9.957494e-01	10	15	0	88	2		0	0	0	0	0	2	1	1.000000	161	434	0	86	2								-20.000000	1	1	0	0		1	2	2	4	2.258998	1	0.370000	2.950000	0.526066	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
FCGBP	8857	broad.mit.edu	37	19	40368392	40368392	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:40368392T>C	ENST00000221347.6	-	28	12963	c.12956A>G	c.(12955-12957)gAc>gGc	p.D4319G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein			165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)		GCAAAGAATGTCACGGTCCCC	0.622000																								0							SO:0001583	missense			ENST00000221347.6	1	1	hg19	CCDS12546.1	.	.	.	.	.	.	.	.	.	.	T	3.672000	-0.067331	0.072730	.	.	ENSG00000090920	ENST00000221347	T	0.78246	-1.16	4.080000	4.080000	0.476270	Uncharacterised domain, cysteine-rich (2);	0.412810	0.23912	U	0.043327	T	0.74442	0.3717	M	0.61703	1.905	0.222800	N	0.999235	B	0.21071	0.051	B	0.22386	0.039	T	0.68205	-0.5470	10	0.54805	T	0.06	.	12.440400	0.556210	0.0:0.0:0.0:1.0	.	4319	Q9Y6R7	FCGBP_HUMAN	G	4319	ENSP00000221347:D4319G	ENSP00000221347:D4319G	D	-	2	0	FCGBP	45060232	0	0.058580	7.590000e-01	0.313400	4.000000e-02	0.135500	0.602000	0.241340	1.848000	0.536770	0.254000	0.183690	GAC		TCGA-HZ-7922-01A-11D-2154-08	FCGBP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000462507.1	1	0	0	77	972	0	185	0	3.895057e-01	0	18	0	185	2		0	0	0	0	0	2	1	1.000000	74	893	0	194	2								-15.187380	1	1	0	0		1	2	2	4	2.258998	1	0.370000	2.950000	0.526066	0.530000	0.410000	1.000000	0.530000	0.574331	0.530000	0	4.700000e-01	6.200000e-01
PHLDB3	653583	broad.mit.edu	37	19	44006338	44006338	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:44006338T>C	ENST00000292140.5	-	3	671	c.311A>G	c.(310-312)cAg>cGg	p.Q104R	PHLDB3_ENST00000599242.1_Missense_Mutation_p.Q104R	NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3			7		Prostate(69;0.0153)			CTCCAGCTGCTGTCCTTGCAG	0.672000																								0							SO:0001583	missense			ENST00000292140.5	1	0	hg19	CCDS12621.2	.	.	.	.	.	.	.	.	.	.	T	8.751000	0.921249	0.179820	.	.	ENSG00000176531	ENST00000292140	T	0.46063	0.88	4.020000	2.950000	0.342190	.	0.735759	0.12304	N	0.480900	T	0.26048	0.0635	L	0.29908	0.895	0.229890	N	0.998464	P;B	0.42584	0.784;0.139	B;B	0.36808	0.233;0.039	T	0.06373	-1.0830	10	0.24483	T	0.36	.	6.699200	0.232150	0.211:0.0:0.0:0.789	.	104;104	Q6NSJ2-2;Q6NSJ2	.;PHLB3_HUMAN	R	104	ENSP00000292140:Q104R	ENSP00000292140:Q104R	Q	-	2	0	PHLDB3	48698178	1	0.714170	9.400000e-01	0.379240	1.720000e-01	0.227750	2.318000	0.437790	0.512000	0.282570	0.254000	0.183690	CAG		TCGA-HZ-7922-01A-11D-2154-08	PHLDB3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000319643.2	1	0	1	9	34	0	13	0	1.322849e-01	0	3	0	13	2		0	0	0	0	0	2	1	0.995427	9	33	0	12	2								-18.768950	1	1	0	0		1	2	2	4	2.321842	1	0.370000	2.950000	0.540146	0.990000	0.820000	1.000000	1.000000	0.989646	0.990000	1	9.900000e-01	1
VRK3	51231	broad.mit.edu	37	19	50504080	50504080	+	Silent	SNP	T	T	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:50504080T>C	ENST00000599538.1	-	6	1243	c.579A>G	c.(577-579)tcA>tcG	p.S193S	VRK3_ENST00000593919.1_Silent_p.S193S|VRK3_ENST00000377011.2_Silent_p.S143S|VRK3_ENST00000601912.1_Silent_p.S143S|VRK3_ENST00000601341.1_Silent_p.S143S|VRK3_ENST00000316763.3_Silent_p.S193S|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000443401.2_Missense_Mutation_p.Q13R|VRK3_ENST00000594948.1_Silent_p.S193S|VRK3_ENST00000594092.1_Silent_p.S193S			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3			23		all_neural(266;0.0459)|Ovarian(192;0.0481)			TCTGTGGTCCTGAGTCACAGG	0.542000													Pancreas(6;90 181 4352 12603 17050 34726 35237 44094)											0							SO:0001819	synonymous_variant			ENST00000599538.1	1	1	hg19	CCDS12791.1	.	.	.	.	.	.	.	.	.	.	T	9.531000	1.110884	0.207140	.	.	ENSG00000105053	ENST00000443401	T	0.29397	1.57	3.450000	-0.215000	0.131570	.	.	.	.	.	T	0.10937	0.0267	.	.	.	0.093100	N	0.999994	B	0.09022	0.002	B	0.12156	0.007	T	0.35724	-0.9777	8	0.02654	T	1	-1.2996	6.412700	0.217000	0.0:0.5503:0.0:0.4497	.	13	B4DGW1	.	R	13	ENSP00000414907:Q13R	ENSP00000414907:Q13R	Q	-	2	0	VRK3	55195892	1.000000e-03	0.127200	1.100000e-02	0.149720	9.000000e-03	0.068530	-0.829000	0.044150	-0.078000	0.127300	0.533000	0.621200	CAG		TCGA-HZ-7922-01A-11D-2154-08	VRK3-009	KNOWN	alternative_5_UTR|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000464815.1	0	0	1	26	162	0	24	1	9.999999e-01	25	153	0	24	2		0	0	0	0	0	2	1	1.000000	25	160	0	24	2								-20.000000	1	1	0	0		1	2	5	7	2.904407	1	0.370000	2.950000	0.632063	0.990000	0.890000	1.000000	1.000000	0.993801	0.990000	1	9.900000e-01	1
KLK1	3816	broad.mit.edu	37	19	51322554	51322554	+	Missense_Mutation	SNP	A	A	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:51322554A>T	ENST00000301420.2	-	5	720	c.685T>A	c.(685-687)Tca>Aca	p.S229T	KLK1_ENST00000448701.2_Missense_Mutation_p.S127T|CTD-2568A17.5_ENST00000326989.5_lincRNA	NM_002257.2	NP_002248.1	P06870	KLK1_HUMAN	kallikrein 1			13		all_neural(266;0.0199)		Aprotinin(DB06692)	TAGCCCCATGATGTGACACCT	0.582000																								0							SO:0001583	missense			ENST00000301420.2	1	1	hg19	CCDS12804.1	.	.	.	.	.	.	.	.	.	.	a	17.350000	3.367908	0.615130	.	.	ENSG00000167748	ENST00000301420;ENST00000448701	D;D	0.92495	-3.05;-3.05	3.660000	2.640000	0.314450	Peptidase cysteine/serine, trypsin-like (1);Peptidase S1/S6, chymotrypsin/Hap (3);	.	.	.	.	D	0.95661	0.8589	M	0.90977	3.165	0.238090	N	0.996785	P	0.52577	0.954	D	0.64321	0.924	D	0.88183	0.2872	9	0.87932	D	0	.	5.740400	0.180890	0.8762:0.0:0.1238:0.0	.	229	P06870	KLK1_HUMAN	T	229;127	ENSP00000301420:S229T;ENSP00000400994:S127T	ENSP00000301420:S229T	S	-	1	0	KLK1	56014366	1	0.714170	1.100000e-02	0.149720	1.400000e-02	0.085840	5.317000	0.658220	0.764000	0.331970	0.459000	0.354650	TCA		TCGA-HZ-7922-01A-11D-2154-08	KLK1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000464135.2	1	0	1	175	247	0	61	1	1	4	416	0	61	2		0	0	0	0	0	2	1	1.000000	174	242	0	60	2								-20.000000	1	1	0	0		1	2	5	7	2.904407	1	0.370000	2.950000	0.632063	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
KLK1	3816	broad.mit.edu	37	19	51322555	51322555	+	Silent	SNP	T	T	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:51322555T>G	ENST00000301420.2	-	5	719	c.684A>C	c.(682-684)acA>acC	p.T228T	KLK1_ENST00000448701.2_Silent_p.T126T|CTD-2568A17.5_ENST00000326989.5_lincRNA	NM_002257.2	NP_002248.1	P06870	KLK1_HUMAN	kallikrein 1			13		all_neural(266;0.0199)		Aprotinin(DB06692)	AGCCCCATGATGTGACACCTT	0.577000																								0							SO:0001819	synonymous_variant			ENST00000301420.2	1	1	hg19	CCDS12804.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	KLK1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000464135.2	1	0	1	174	248	0	61	1	1	4	409	0	61	2		0	0	0	0	0	2	1	1.000000	173	243	0	60	2								-20.000000	1	1	0	0		1	2	5	7	2.904407	1	0.370000	2.950000	0.632063	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
NLRP4	147945	broad.mit.edu	37	19	56369355	56369355	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr19:56369355C>T	ENST00000301295.6	+	3	1018	c.596C>T	c.(595-597)aCg>aTg	p.T199M	NLRP4_ENST00000346986.5_Missense_Mutation_p.T199M|NLRP4_ENST00000587891.1_Missense_Mutation_p.T124M	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	p.T199M(1)		42		Colorectal(82;0.0002)|Ovarian(87;0.221)			TTGCCGCCAACGAGTTTGGCT	0.517000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000301295.6	1	1	hg19	CCDS12936.1	.	.	.	.	.	.	.	.	.	.	C	8.234000	0.805414	0.164670	4.54E-4	1.16E-4	ENSG00000160505	ENST00000301295;ENST00000346986	T;T	0.78707	-1.2;-1.2	4.110000	-0.400000	0.124110	NACHT nucleoside triphosphatase (1);	.	.	.	.	T	0.60586	0.2280	L	0.33485	1.01	0.093100	N	1.000000	B;B;B	0.32128	0.063;0.051;0.357	B;B;B	0.24394	0.025;0.024;0.053	T	0.45249	-0.9274	9	0.33940	T	0.23	.	6.757000	0.235200	0.0:0.4886:0.0:0.5114	.	199;124;199	Q96MN2-2;Q96MN2-3;Q96MN2	.;.;NALP4_HUMAN	M	199	ENSP00000301295:T199M;ENSP00000344787:T199M	ENSP00000301295:T199M	T	+	2	0	NLRP4	61061167	0	0.058580	1.000000e-03	0.086480	0	0.004340	-0.970000	0.038100	0.152000	0.191880	-1.020000	0.024450	ACG		TCGA-HZ-7922-01A-11D-2154-08	NLRP4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000457367.2	1	0	1	196	751	0	104		0	0	0	0	104	2		0	0	0	0	0	2	1	1.000000	195	740	0	103	2								-20.000000	1	1	121412	9	42	1	2	4	6	2.901888	1	0.370000	2.950000	0.631665	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
CDC14A	8556	broad.mit.edu	37	1	100843110	100843110	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr1:100843110C>A	ENST00000336454.3	+	3	504	c.149C>A	c.(148-150)gCa>gAa	p.A50E	CDC14A_ENST00000361544.6_Missense_Mutation_p.A50E|CDC14A_ENST00000370125.2_Missense_Mutation_p.A50E|AC104457.1_ENST00000401248.1_RNA|CDC14A_ENST00000370124.3_Missense_Mutation_p.A50E|CDC14A_ENST00000544534.1_Missense_Mutation_p.A50E|CDC14A_ENST00000542213.1_5'UTR	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A			31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)			AGTTTCTATGCAGATTTTGGA	0.279000																								0							SO:0001583	missense			ENST00000336454.3	1	1	hg19	CCDS769.1	.	.	.	.	.	.	.	.	.	.	C	15.970000	2.988957	0.539340	.	.	ENSG00000079335	ENST00000455467;ENST00000370125;ENST00000361544;ENST00000370124;ENST00000336454;ENST00000544534	T;T;T;T;T;T	0.45276	0.9;0.9;0.9;0.9;0.9;0.9	5.640000	5.640000	0.866020	.	0.000000	0.85682	D	0.000000	T	0.31544	0.0800	M	0.65677	2.01	0.807220	D	1.000000	P;B;P;P;B	0.37708	0.471;0.091;0.471;0.606;0.055	B;B;B;B;B	0.33799	0.082;0.041;0.118;0.17;0.018	T	0.17077	-1.0381	10	0.38643	T	0.18	-14.0376	18.465400	0.907520	0.0:1.0:0.0:0.0	.	50;50;50;50;50	A6MA65;Q9UNH5-3;Q9UNH5;Q9UNH5-2;Q52LH9	.;.;CC14A_HUMAN;.;.	E	51;50;50;50;50;50	ENSP00000388501:A51E;ENSP00000359143:A50E;ENSP00000354916:A50E;ENSP00000359142:A50E;ENSP00000336739:A50E;ENSP00000442543:A50E	ENSP00000336739:A50E	A	+	2	0	CDC14A	100615698	1	0.714170	1	0.803570	9.690000e-01	0.656310	4.228000	0.586190	2.660000	0.904300	0.455000	0.322230	GCA		TCGA-HZ-7922-01A-11D-2154-08	CDC14A-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000030220.1	1	0	1	29	207	0	30	0	3.640681e-01	1	9	0	30	2		0	0	0	0	0	2	1	1.000000	29	205	0	30	2								-13.560680	1	1	0	0		1	1	2	3	2.049050	1	0.370000	2.950000	0.468354	0.790000	0.540000	1.000000	1.000000	0.797519	0.790000	0	6.600000e-01	9.300000e-01
KCNT2	343450	broad.mit.edu	37	1	196227479	196227479	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr1:196227479C>T	ENST00000294725.9	-	26	3971	c.3056G>A	c.(3055-3057)cGa>cAa	p.R1019Q	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000609185.1_Missense_Mutation_p.R952Q|KCNT2_ENST00000367431.4_Missense_Mutation_p.R953Q|KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000367433.5_Missense_Mutation_p.R995Q			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	p.R1019Q(1)		97					GCTCAGTCTTCGGGCCCACTG	0.512000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000294725.9	1	1	hg19	CCDS1384.1	.	.	.	.	.	.	.	.	.	.	C	23.700000	4.444207	0.839930	.	.	ENSG00000162687	ENST00000367433;ENST00000367431;ENST00000294725	T;T;T	0.23950	1.88;1.93;2.23	5.740000	4.830000	0.623500	.	0.000000	0.49305	D	0.000152	T	0.49847	0.1581	M	0.78916	2.43	0.807220	D	1.000000	D;D;D;D	0.76494	0.999;0.99;0.967;0.983	D;P;P;P	0.65443	0.935;0.674;0.556;0.474	T	0.51803	-0.8659	10	0.41790	T	0.15	-7.0387	14.714800	0.692590	0.0:0.9307:0.0:0.0693	.	984;995;952;1019	Q6UVM3-4;Q6UVM3-2;Q6UVM3-3;Q6UVM3	.;.;.;KCNT2_HUMAN	Q	995;953;1019	ENSP00000356403:R995Q;ENSP00000356401:R953Q;ENSP00000294725:R1019Q	ENSP00000294725:R1019Q	R	-	2	0	KCNT2	194494102	1	0.714170	9.940000e-01	0.499520	9.880000e-01	0.763860	7.487000	0.813280	1.437000	0.474720	-0.148000	0.137560	CGA		TCGA-HZ-7922-01A-11D-2154-08	KCNT2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000086418.2	1	0	1	120	312	0	37	0	0	0	1	0	37	2		0	0	0	0	0	2	1	1.000000	120	308	0	37	2								-7.488261	1	1	121408	1	31	1	1	2	3	2.030260	1	0.370000	2.950000	0.468354	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
TRIM58	25893	broad.mit.edu	37	1	248039221	248039221	+	Silent	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr1:248039221C>T	ENST00000366481.3	+	6	939	c.891C>T	c.(889-891)ccC>ccT	p.P297P	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	p.P297P(1)		63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)		AGCTGGATCCCGCCACGGCGC	0.537000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000366481.3	1	1	hg19	CCDS1636.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	TRIM58-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000096860.1	1	0	1	57	143	0	33	0	0	0	1	0	33	2		0	0	0	0	0	2	1	1.000000	57	141	0	32	2								-5.515517	1	1	121412	2	30	1	1	2	3	2.030260	1	0.370000	2.950000	0.468354	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
C1orf173	0	broad.mit.edu	37	1	75037471	75037471	+	Missense_Mutation	SNP	G	G	A	rs138615520		TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr1:75037471G>A	ENST00000326665.5	-	14	4141	c.3923C>T	c.(3922-3924)gCg>gTg	p.A1308V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	ERIC3_HUMAN		p.A1308V(1)		184					GTCCTGCATCGCTTCTGTCTC	0.542000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000326665.5	1	1	hg19	CCDS30755.1	.	.	.	.	.	.	.	.	.	.	G	0.460000	-0.889610	0.025110	.	.	ENSG00000178965	ENST00000326665	T	0.09723	2.95	3.580000	-4.770000	0.032190	.	.	.	.	.	T	0.00967	0.0032	N	0.03608	-0.345	0.093100	N	1.000000	B	0.02656	0.0	B	0.01281	0.0	T	0.47598	-0.9105	9	0.28530	T	0.3	-0.0061	3.793500	0.087300	0.4175:0.0:0.3159:0.2666	.	1308	Q5RHP9	CA173_HUMAN	V	1308	ENSP00000322609:A1308V	ENSP00000322609:A1308V	A	-	2	0	C1orf173	74810059	0	0.058580	0	0.037020	7.000000e-03	0.059690	-0.543000	0.060840	-0.741000	0.047970	-0.672000	0.038020	GCG		TCGA-HZ-7922-01A-11D-2154-08	C1orf173-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000026516.1	1	0	1	117	729	0	126		0	0	0	0	126	2		0	0	0	0	0	2	1	1.000000	118	723	0	124	2								-20.000000	1	1	0	0		1	1	2	3	2.049050	1	0.370000	2.950000	0.468354	0.880000	0.730000	1.000000	1.000000	0.887127	0.880000	1	8.000000e-01	9.600000e-01
ELTD1	64123	broad.mit.edu	37	1	79392719	79392719	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr1:79392719G>T	ENST00000370742.3	-	8	998	c.935C>A	c.(934-936)tCt>tAt	p.S312Y		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1			69					GAAGTTGTCAGATGATGAAAG	0.318000																								0							SO:0001583	missense			ENST00000370742.3	1	1	hg19	CCDS41352.1	.	.	.	.	.	.	.	.	.	.	G	14.920000	2.677924	0.478860	.	.	ENSG00000162618	ENST00000370742	T	0.10668	2.85	6.020000	5.080000	0.687300	Domain of unknown function DUF3497 (1);	0.387514	0.33075	N	0.005305	T	0.13157	0.0319	L	0.47716	1.5	0.353060	D	0.783468	D	0.60160	0.987	D	0.65323	0.934	T	0.03981	-1.0987	9	.	.	.	.	11.966300	0.530380	0.0:0.1317:0.7313:0.137	.	312	Q9HBW9	ELTD1_HUMAN	Y	312	ENSP00000359778:S312Y	.	S	-	2	0	ELTD1	79165307	1	0.714170	1	0.803570	3.790000e-01	0.301060	2.927000	0.489000	1.495000	0.485490	0.544000	0.684100	TCT		TCGA-HZ-7922-01A-11D-2154-08	ELTD1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000026859.1	1	0	1	47	310	0	52	0	9.320580e-01	0	32	0	52	2		0	0	0	0	0	2	1	1.000000	47	308	0	52	2								-19.681960	1	1	0	0		1	1	2	3	2.049050	1	0.370000	2.950000	0.468354	0.840000	0.630000	1.000000	1.000000	0.847207	0.840000	0	7.300000e-01	9.600000e-01
KRTAP6-1	337966	broad.mit.edu	37	21	31986063	31986063	+	Missense_Mutation	SNP	C	C	T	rs28567421	byFrequency	TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr21:31986063C>T	ENST00000329122.2	-	1	186	c.161G>A	c.(160-162)cGc>cAc	p.R54H	KRTAP20-1_ENST00000334664.2_5'Flank	NM_181602.1	NP_853633.1	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1			10					ACAGAGGGAGCGGGAGCCATA	0.587000																								0							SO:0001583	missense			ENST00000329122.2	1	1	hg19	CCDS13602.1	3	0.0013736263736263737	3	0.006097560975609756	0	0.0	0	0.0	0	0.0	C	4.286000	0.052327	0.082910	0.003404	4.65E-4	ENSG00000184724	ENST00000329122	T	0.20069	2.1	4.880000	0.801000	0.186790	.	0.870871	0.09244	U	0.828807	T	0.09158	0.0226	.	.	.	0.093100	N	1.000000	B	0.11235	0.004	B	0.08055	0.003	T	0.36040	-0.9764	9	0.87932	D	0	.	1.117500	0.017180	0.1567:0.4229:0.1522:0.2683	rs28567421	54	Q3LI64	KRA61_HUMAN	H	54	ENSP00000332690:R54H	ENSP00000332690:R54H	R	-	2	0	KRTAP6-1	30907934	1.000000e-03	0.127200	1.000000e-03	0.086480	1.180000e-01	0.200600	-0.881000	0.041790	0.043000	0.157460	0.643000	0.837060	CGC		TCGA-HZ-7922-01A-11D-2154-08	KRTAP6-1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000128240.2	1	0	1	120	422	0	141		0	0	0	0	141	2		0	0	0	0	0	2	1	1.000000	120	419	0	140	2								-2.755114	1	1	121408	87	54	1	0	1	1	1.400316	1	0.370000	2.950000	0.226994	0.930000	0.800000	1.000000	0.970000	0.929642	0.930000	1	8.700000e-01	9.800000e-01
AGPAT3	56894	broad.mit.edu	37	21	45389013	45389013	+	Silent	SNP	C	C	A	rs146737372	byFrequency	TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr21:45389013C>A	ENST00000398063.2	+	4	855	c.363C>A	c.(361-363)ctC>ctA	p.L121L	AGPAT3_ENST00000327505.2_Silent_p.L121L|AGPAT3_ENST00000398061.1_Silent_p.L121L|AGPAT3_ENST00000398058.1_Silent_p.L121L|AGPAT3_ENST00000291572.8_Silent_p.L121L|AGPAT3_ENST00000479117.1_3'UTR|AGPAT3_ENST00000546158.1_Silent_p.L121L	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3			11					CCAAGGTCCTCGCTAAGAAGG	0.637000													Pancreas(60;623 1650 5574 52796)											0							SO:0001819	synonymous_variant			ENST00000398063.2	0	1	hg19	CCDS13703.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	AGPAT3-004	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000195722.1	0	0	0	8	225	0	47	0	9.014672e-01	0	118	0	47	2		0	0	0	0	0	2	1	0.989357	8	223	0	46	2								-2.886319	1	1	121412	79	50	1	0	2	2	1.696981	1	0.370000	2.950000	0.370000	0.190000	0.080000	0.340000	0.180000	0.205493	0.190000	0	1.300000e-01	2.700000e-01
COL6A2	1292	broad.mit.edu	37	21	47538549	47538549	+	Missense_Mutation	SNP	C	C	T	rs142880107		TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr21:47538549C>T	ENST00000300527.4	+	13	1242	c.1138C>T	c.(1138-1140)Cgc>Tgc	p.R380C	COL6A2_ENST00000357838.4_Missense_Mutation_p.R380C|COL6A2_ENST00000397763.1_Missense_Mutation_p.R380C|COL6A2_ENST00000310645.5_Missense_Mutation_p.R380C|COL6A2_ENST00000409416.1_Missense_Mutation_p.R380C	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2			43	Breast(49;0.245)				CCGCCCAGGACGCAGAGGGCC	0.682000																								0							SO:0001583	missense			ENST00000300527.4	1	0	hg19	CCDS13728.1	.	.	.	.	.	.	.	.	.	.	C	16.150000	3.040552	0.550030	2.27E-4	0.0	ENSG00000142173	ENST00000300527;ENST00000357838;ENST00000310645;ENST00000409416;ENST00000397763	D;D;D;D;D	0.93426	-3.2;-3.2;-3.22;-3.22;-3.2	4.690000	4.690000	0.590740	.	0.053823	0.64402	D	0.000001	D	0.95987	0.8693	M	0.67517	2.055	0.807220	D	1.000000	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.79784	0.993;0.987;0.978	D	0.96089	0.9060	10	0.52906	T	0.07	-16.3159	16.605200	0.848260	0.0:1.0:0.0:0.0	.	380;380;380	P12110;P12110-2;P12110-3	CO6A2_HUMAN;.;.	C	380	ENSP00000300527:R380C;ENSP00000350497:R380C;ENSP00000312529:R380C;ENSP00000387115:R380C;ENSP00000380870:R380C	ENSP00000300527:R380C	R	+	1	0	COL6A2	46362977	1	0.714170	1	0.803570	9.820000e-01	0.717510	4.537000	0.606430	2.151000	0.671560	0.591000	0.815410	CGC		TCGA-HZ-7922-01A-11D-2154-08	COL6A2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000206971.1	0	0	1	34	64	0	17	1	1	5	561	0	17	2		0	0	0	0	0	2	1	1.000000	33	63	0	17	2								-20.000000	1	0	120968	3	34	1	0	2	2	1.696981	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	0.999995	0.990000	1	9.900000e-01	1
NEFH	4744	broad.mit.edu	37	22	29886317	29886317	+	Silent	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr22:29886317G>A	ENST00000310624.6	+	4	2721	c.2688G>A	c.(2686-2688)gaG>gaA	p.E896E		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide			30					AGAAGGAAGAGGCTGAAGATA	0.512000																								0							SO:0001819	synonymous_variant			ENST00000310624.6	1	1	hg19	CCDS13858.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	NEFH-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000321553.2	1	0	1	43	104	0	26	0	9.548104e-01	0	15	0	26	2		0	0	0	0	0	2	1	1.000000	43	102	0	26	2								-20.000000	1	1	0	0		1	2	2	4	2.299521	1	0.370000	2.950000	0.535124	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
TTN	7273	broad.mit.edu	37	2	179579858	179579858	+	Silent	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr2:179579858G>A	ENST00000591111.1	-	88	25328	c.25104C>T	c.(25102-25104)agC>agT	p.S8368S	TTN_ENST00000342992.6_Silent_p.S7441S|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000589042.1_Silent_p.S8685S|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron			Q8WZ42	TITIN_HUMAN	titin			1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)		ACTTCTTGCCGCTCCTAAGTT	0.443000																								0							SO:0001819	synonymous_variant			ENST00000591111.1	1	1	hg19																																																																																					TCGA-HZ-7922-01A-11D-2154-08	TTN-019	PUTATIVE	basic	protein_coding	protein_coding	OTTHUMT00000460310.1	0	0	0	327	603	1	212		0	0	0	1	212	2		0	0	0	0	0	2	1	1.000000	324	599	0	209	2								-20.000000	1	1	0	0		1	0	2	2	1.805913	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
ABCA12	26154	broad.mit.edu	37	2	215835096	215835096	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr2:215835096G>A	ENST00000272895.7	-	37	5810	c.5591C>T	c.(5590-5592)cCg>cTg	p.P1864L	ABCA12_ENST00000389661.4_Missense_Mutation_p.P1546L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12			139		Renal(323;0.127)			TCTTCTGTGCGGTGGGGAATA	0.358000													Ovarian(66;664 1488 5121 34295)											0							SO:0001583	missense			ENST00000272895.7	1	1	hg19	CCDS33372.1	1	4.578754578754579E-4	0	0.0	1	0.0027624309392265192	0	0.0	0	0.0	G	25.700000	4.669881	0.883480	2.27E-4	0.0	ENSG00000144452	ENST00000272895;ENST00000389661	D;D	0.96300	-3.97;-3.88	5.290000	5.290000	0.746850	.	0.000000	0.51477	D	0.000093	D	0.98071	0.9364	M	0.76838	2.35	0.807220	D	1.000000	D;D	0.89917	1.0;1.0	D;D	0.91635	0.999;0.998	D	0.98850	1.0758	10	0.87932	D	0	.	18.908400	0.924720	0.0:0.0:1.0:0.0	.	1864;1546	Q86UK0;Q86UK0-2	ABCAC_HUMAN;.	L	1864;1546	ENSP00000272895:P1864L;ENSP00000374312:P1546L	ENSP00000272895:P1864L	P	-	2	0	ABCA12	215543341	1	0.714170	1	0.803570	9.930000e-01	0.825480	7.752000	0.851410	2.640000	0.895330	0.650000	0.862430	CCG		TCGA-HZ-7922-01A-11D-2154-08	ABCA12-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000337111.1	1	0	1	74	358	0	48	1	2.088696e-01	2	3	0	48	2		0	0	0	0	0	2	1	1.000000	74	358	0	48	2								-2.610414	1	1	121410	17	47	1	1	3	4	2.093159	1	0.370000	2.950000	0.479726	0.990000	0.910000	1.000000	1.000000	0.994112	0.990000	1	9.900000e-01	1
XDH	7498	broad.mit.edu	37	2	31625970	31625970	+	Silent	SNP	G	G	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr2:31625970G>T	ENST00000379416.3	-	3	189	c.141C>A	c.(139-141)ggC>ggA	p.G47G		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase			74	Acute lymphoblastic leukemia(172;0.155)			Aldesleukin(DB00041)|Allopurinol(DB00437)|Azathioprine(DB00993)|Carboplatin(DB00958)|Carvedilol(DB01136)|Chlorphenesin(DB00856)|Cisplatin(DB00515)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Doxorubicin(DB00997)|Flavin adenine dinucleotide(DB03147)|L-Carnitine(DB00583)|Menadione(DB00170)|Mercaptopurine(DB01033)|Nitrofural(DB00336)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Spermine(DB00127)|Trifluoperazine(DB00831)	AAGCCCCGCAGCCCCCCTCTC	0.577000													Colon(66;682 1445 30109 40147)											0							SO:0001819	synonymous_variant			ENST00000379416.3	1	1	hg19	CCDS1775.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	XDH-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000216840.1	1	0	1	50	402	0	81	1	6.112028e-01	3	15	0	81	2		0	0	0	0	0	2	1	1.000000	50	400	0	80	2								-1.920854	0	1	0	0		1	1	2	3	2.017034	1	0.370000	2.950000	0.468354	0.700000	0.530000	0.900000	0.720000	0.717638	0.700000	0	6.100000e-01	8.100000e-01
DYSF	8291	broad.mit.edu	37	2	71795377	71795377	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr2:71795377G>A	ENST00000258104.3	+	26	2996	c.2719G>A	c.(2719-2721)Gtc>Atc	p.V907I	DYSF_ENST00000429174.2_Missense_Mutation_p.V907I|DYSF_ENST00000410020.3_Missense_Mutation_p.V925I|DYSF_ENST00000413539.2_Missense_Mutation_p.V938I|DYSF_ENST00000409762.1_Missense_Mutation_p.V924I|DYSF_ENST00000409651.1_Missense_Mutation_p.V939I|DYSF_ENST00000409744.1_Missense_Mutation_p.V894I|DYSF_ENST00000409582.3_Missense_Mutation_p.V924I|DYSF_ENST00000409366.1_Missense_Mutation_p.V908I|DYSF_ENST00000394120.2_Missense_Mutation_p.V908I|DYSF_ENST00000410041.1_Missense_Mutation_p.V925I	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin			111					GTTTTCTGACGTCACGGGCAA	0.592000																								0							SO:0001583	missense			ENST00000258104.3	1	1	hg19	CCDS1918.1	.	.	.	.	.	.	.	.	.	.	G	9.616000	1.132447	0.210410	.	.	ENSG00000135636	ENST00000413539;ENST00000409762;ENST00000409582;ENST00000429174;ENST00000258104;ENST00000409651;ENST00000394120;ENST00000409744;ENST00000409366;ENST00000410020;ENST00000410041	D;D;D;D;D;D;D;D;D;D;D	0.83075	-1.67;-1.68;-1.68;-1.67;-1.67;-1.67;-1.67;-1.67;-1.67;-1.67;-1.68	4.940000	4.060000	0.473250	Ferlin/Peroxisome membrane (1);	0.213952	0.40385	N	0.001118	T	0.73040	0.3536	L	0.28344	0.845	0.395640	D	0.969175	B;B;B;B;B;B;B;B;B;B;B;B;B;B	0.20261	0.039;0.039;0.039;0.011;0.043;0.005;0.012;0.012;0.011;0.003;0.002;0.011;0.011;0.007	B;B;B;B;B;B;B;B;B;B;B;B;B;B	0.23150	0.03;0.03;0.018;0.018;0.03;0.018;0.03;0.044;0.018;0.005;0.007;0.018;0.018;0.008	T	0.69228	-0.5200	10	0.46703	T	0.11	-30.2846	11.127300	0.483250	0.091:0.0:0.909:0.0	.	939;925;908;894;925;894;924;893;938;924;907;893;908;907	O75923-8;O75923-13;O75923-10;O75923-9;O75923-11;O75923-12;O75923-5;O75923-6;O75923-2;O75923-7;O75923-4;O75923-3;O75923-14;O75923	.;.;.;.;.;.;.;.;.;.;.;.;.;DYSF_HUMAN	I	938;924;924;907;907;939;908;894;908;925;925	ENSP00000407046:V938I;ENSP00000387137:V924I;ENSP00000386547:V924I;ENSP00000398305:V907I;ENSP00000258104:V907I;ENSP00000386683:V939I;ENSP00000377678:V908I;ENSP00000386285:V894I;ENSP00000386512:V908I;ENSP00000386881:V925I;ENSP00000386617:V925I	ENSP00000258104:V907I	V	+	1	0	DYSF	71648885	8.960000e-01	0.305650	5.930000e-01	0.287710	2.510000e-01	0.259150	1.328000	0.337580	1.080000	0.410730	0.448000	0.294170	GTC		TCGA-HZ-7922-01A-11D-2154-08	DYSF-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000251970.3	1	0	1	267	1490	0	319	0	8.296928e-01	0	20	0	319	2		0	0	0	0	0	2	1	1.000000	265	1476	0	319	2								-20.000000	1	1	0	0		1	1	2	3	2.017034	1	0.370000	2.950000	0.468354	0.960000	0.860000	1.000000	1.000000	0.963006	0.960000	1	9.100000e-01	1
PLA1A	51365	broad.mit.edu	37	3	119327676	119327676	+	Missense_Mutation	SNP	C	C	T	rs145457987	byFrequency	TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr3:119327676C>T	ENST00000273371.4	+	3	407	c.335C>T	c.(334-336)aCg>aTg	p.T112M	PLA1A_ENST00000495992.1_Missense_Mutation_p.T112M|PLA1A_ENST00000488919.1_5'UTR|PLA1A_ENST00000494440.1_Missense_Mutation_p.T96M	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A			30					CTGCGTGCAACGAATGCTAAT	0.438000																								0							SO:0001583	missense			ENST00000273371.4	1	1	hg19	CCDS2991.1	.	.	.	.	.	.	.	.	.	.	C	3.694000	-0.062843	0.072730	0.001362	0.0	ENSG00000144837	ENST00000273371;ENST00000495992;ENST00000494440	D;D;D	0.90955	-2.68;-2.76;-2.68	5.170000	2.190000	0.278520	Lipase, N-terminal (1);	0.669254	0.16089	N	0.230123	T	0.79299	0.4422	N	0.16266	0.395	0.093100	N	1.000000	P;B	0.47545	0.897;0.008	B;B	0.40329	0.326;0.005	T	0.72408	-0.4303	10	0.66056	D	0.02	-0.7573	2.970400	0.059200	0.2767:0.4081:0.2293:0.0858	.	112;112	Q53H76-3;Q53H76	.;PLA1A_HUMAN	M	112;112;96	ENSP00000273371:T112M;ENSP00000417326:T112M;ENSP00000418793:T96M	ENSP00000273371:T112M	T	+	2	0	PLA1A	120810366	6.000000e-03	0.163420	1.000000e-03	0.086480	1.400000e-02	0.085840	0.401000	0.209480	0.549000	0.289730	0.462000	0.415740	ACG		TCGA-HZ-7922-01A-11D-2154-08	PLA1A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000355252.2	1	0	1	205	630	0	145	0	9.121586e-01	0	15	0	145	2		0	0	0	0	0	2	1	1.000000	204	627	0	144	2								-3.142967	1	1	121412	3	49	1	2	2	4	2.339257	1	0.370000	2.950000	0.540146	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
SI	6476	broad.mit.edu	37	3	164764706	164764706	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr3:164764706C>A	ENST00000264382.3	-	16	1872	c.1810G>T	c.(1810-1812)Gac>Tac	p.D604Y		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)			218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)		Acarbose(DB00284)|Scopolamine(DB00747)	GCAGTATTGTCTCCTAACCAA	0.393000										HNSCC(35;0.089)														0							SO:0001583	missense			ENST00000264382.3	0	1	hg19	CCDS3196.1	.	.	.	.	.	.	.	.	.	.	C	24.600000	4.544210	0.860220	.	.	ENSG00000090402	ENST00000264382	D	0.97906	-4.6	5.360000	5.360000	0.768440	Glycoside hydrolase, superfamily (1);	0.000000	0.85682	D	0.000000	D	0.99354	0.9773	H	0.98918	4.37	0.807220	D	1.000000	D	0.89917	1.0	D	0.97110	1.0	D	0.98404	1.0569	10	0.87932	D	0	.	18.071200	0.894070	0.0:1.0:0.0:0.0	.	604	P14410	SUIS_HUMAN	Y	604	ENSP00000264382:D604Y	ENSP00000264382:D604Y	D	-	1	0	SI	166247400	1	0.714170	1	0.803570	9.890000e-01	0.773840	7.356000	0.794450	2.519000	0.849330	0.467000	0.429560	GAC		TCGA-HZ-7922-01A-11D-2154-08	SI-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000350116.1	0	0	0	12	595	0	79		0	0	0	0	79	2		0	0	0	0	0	2	1	0.999089	12	591	0	79	2								-2.986354	1	1	0	0		1	2	2	4	2.344781	1	0.370000	2.950000	0.540146	0.140000	0.070000	0.250000	0.160000	0.157856	0.140000	0	1.000000e-01	2.000000e-01
ATRIP	84126	broad.mit.edu	37	3	48491541	48491541	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr3:48491541G>A	ENST00000320211.3	+	2	459	c.346G>A	c.(346-348)Gta>Ata	p.V116I	ATRIP_ENST00000412052.1_Missense_Mutation_p.V23I|ATRIP_ENST00000357105.6_5'UTR|ATRIP_ENST00000346691.4_Missense_Mutation_p.V116I	NM_130384.2	NP_569055.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein			22					CGAATTAGAGGTACTTCAGGC	0.333000								Other conserved DNA damage response genes																0							SO:0001583	missense			ENST00000320211.3	1	1	hg19	CCDS2768.1	.	.	.	.	.	.	.	.	.	.	G	12.670000	2.007454	0.354150	.	.	ENSG00000164053	ENST00000421175;ENST00000320211;ENST00000346691;ENST00000412052	T;T;T;T	0.78126	-1.15;1.43;1.43;1.44	5.510000	-2.400000	0.065830	.	1.023550	0.07743	N	0.947318	T	0.70159	0.3192	M	0.61703	1.905	0.439530	D	0.996621	B;B	0.12013	0.005;0.005	B;B	0.09377	0.004;0.004	T	0.56739	-0.7929	10	0.42905	T	0.14	-0.3582	5.732800	0.180490	0.1973:0.0:0.3847:0.418	.	116;116	Q8WXE1-2;Q8WXE1	.;ATRIP_HUMAN	I	23;116;116;23	ENSP00000406664:V23I;ENSP00000323099:V116I;ENSP00000302338:V116I;ENSP00000400930:V23I	ENSP00000323099:V116I	V	+	1	0	ATRIP	48466545	9.250000e-01	0.313640	6.460000e-01	0.294930	9.670000e-01	0.649340	0.191000	0.170760	-0.420000	0.074270	0.655000	0.942530	GTA		TCGA-HZ-7922-01A-11D-2154-08	ATRIP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257507.2	1	0	1	240	344	0	83	0	9.588175e-01	1	9	0	83	2		0	0	0	0	0	2	1	1.000000	239	342	0	82	2								-20.000000	1	1	0	0		1	0	2	2	1.715143	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
ROBO1	6091	broad.mit.edu	37	3	78734918	78734918	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	A	C	C		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr3:78734918C>A	ENST00000464233.1	-	10	1433	c.1320G>T	c.(1318-1320)aaG>aaT	p.K440N	ROBO1_ENST00000467549.1_Missense_Mutation_p.K404N|ROBO1_ENST00000495273.1_Missense_Mutation_p.K404N|ROBO1_ENST00000436010.2_Missense_Mutation_p.K401N	NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)			44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)			CCAAATATGCCTTTGTGATGA	0.383000																								0							SO:0001583	missense			ENST00000464233.1	1	1	hg19	CCDS54611.1	.	.	.	.	.	.	.	.	.	.	C	15.090000	2.730545	0.489390	.	.	ENSG00000169855	ENST00000436010;ENST00000398412;ENST00000464233;ENST00000495273;ENST00000467549;ENST00000398414	T;T;T;T	0.69040	-0.37;-0.37;-0.37;-0.37	5.280000	-2.110000	0.071870	Immunoglobulin I-set (1);Immunoglobulin-like (1);Immunoglobulin-like fold (1);	0.088124	0.85682	D	0.000000	T	0.66915	0.2838	L	0.31845	0.965	0.503130	D	0.999865	D;D;D;D;D	0.89917	1.0;1.0;1.0;1.0;1.0	D;D;D;D;D	0.97110	0.998;1.0;0.999;1.0;1.0	T	0.61525	-0.7045	9	.	.	.	.	10.421100	0.443500	0.0:0.3686:0.0:0.6314	.	404;440;404;404;401	Q1RMC7;Q9Y6N7;B2RXI1;E9PD49;Q9Y6N7-4	.;ROBO1_HUMAN;.;.;.	N	401;404;440;404;404;440	ENSP00000406043:K401N;ENSP00000420321:K440N;ENSP00000420637:K404N;ENSP00000417992:K404N	.	K	-	3	2	ROBO1	78817608	1	0.714170	9.850000e-01	0.450670	4.600000e-01	0.325590	0.961000	0.292670	-0.550000	0.061830	-0.251000	0.115420	AAG		TCGA-HZ-7922-01A-11D-2154-08	ROBO1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000352610.1	1	0	1	24	60	0	22	0	9.968346e-01	0	27	0	22	2		0	0	0	0	0	2	1	1.000000	24	60	0	22	2								-20.000000	1	1	0	0		1	0	2	2	1.715143	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	0.999100	0.990000	1	9.900000e-01	1
MAEA	10296	broad.mit.edu	37	4	1283769	1283769	+	Splice_Site	SNP	A	A	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr4:1283769A>G	ENST00000303400.4	+	1	131	c.68A>G	c.(67-69)aAg>aGg	p.K23R	MAEA_ENST00000505177.2_Splice_Site_p.K23R|MAEA_ENST00000452175.2_Splice_Site_p.K12R|CTBP1-AS2_ENST00000578730.1_RNA|MAEA_ENST00000514708.1_Splice_Site_p.K23R|MAEA_ENST00000264750.6_Splice_Site_p.K23R	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher			18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)	WF10(DB05389)	CCGACCCTCAAGGTGGGCGCC	0.716000																								0							SO:0001630	splice_region_variant			ENST00000303400.4	0	1	hg19	CCDS33936.1	.	.	.	.	.	.	.	.	.	.	A	16.400000	3.113236	0.563980	.	.	ENSG00000090316	ENST00000303400;ENST00000505177;ENST00000503653;ENST00000264750;ENST00000382947;ENST00000539495;ENST00000502558;ENST00000452175;ENST00000514708	T;T;T;T;T;T;T	0.47869	1.11;1.04;0.97;1.11;0.9;0.83;1.05	3.360000	3.360000	0.384830	.	0.130255	0.49305	D	0.000158	T	0.34279	0.0892	L	0.35542	1.07	0.339190	D	0.640589	B;B;B;P;B	0.39376	0.136;0.286;0.131;0.67;0.024	B;B;B;B;B	0.39119	0.126;0.203;0.084;0.291;0.016	T	0.42899	-0.9424	10	0.14252	T	0.57	.	11.949700	0.529480	1.0:0.0:0.0:0.0	.	23;23;23;23;23	E7ESC7;Q7L5Y9-2;D6RIB6;Q7L5Y9-3;Q7L5Y9	.;.;.;.;MAEA_HUMAN	R	23;23;23;23;23;23;23;12;23	ENSP00000302830:K23R;ENSP00000422215:K23R;ENSP00000421644:K23R;ENSP00000264750:K23R;ENSP00000426903:K23R;ENSP00000411415:K12R;ENSP00000427512:K23R	ENSP00000264750:K23R	K	+	2	0	MAEA	1273769	1	0.714170	9.990000e-01	0.593770	8.960000e-01	0.523590	6.007000	0.707310	1.406000	0.468570	0.528000	0.532280	AAG		TCGA-HZ-7922-01A-11D-2154-08	MAEA-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000359511.1	0	0	0	6	42	0	10	1	9.799068e-01	3	52	0	10	2		0	0	0	0	0	2	1	0.966152	5	42	0	10	2								-12.790620	1	1	120220	1	23	1	2	2	4	2.309022	1	0.370000	2.950000	0.537649	0.970000	0.420000	1.000000	1.000000	0.868335	0.970000	1	6.600000e-01	1
LRBA	987	broad.mit.edu	37	4	151791686	151791686	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr4:151791686G>C	ENST00000357115.3	-	20	2683	c.2440C>G	c.(2440-2442)Caa>Gaa	p.Q814E	LRBA_ENST00000510413.1_Missense_Mutation_p.Q814E|LRBA_ENST00000507224.1_Missense_Mutation_p.Q814E|LRBA_ENST00000535741.1_Missense_Mutation_p.Q814E	NM_006726.4	NP_006717.2	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing			91	all_hematologic(180;0.151)				CGAGGGTTTTGTATCTTCACT	0.313000																								0							SO:0001583	missense			ENST00000357115.3	1	1	hg19	CCDS3773.1	.	.	.	.	.	.	.	.	.	.	G	10.530000	1.375857	0.248570	.	.	ENSG00000198589	ENST00000535741;ENST00000510413;ENST00000357115;ENST00000507224	T;T;T;T	0.63580	-0.05;-0.05;-0.05;-0.05	5.660000	5.660000	0.874060	Armadillo-type fold (1);	0.413735	0.23682	N	0.045609	T	0.63200	0.2491	L	0.31157	0.91	0.520990	D	0.999940	D;P	0.56968	0.978;0.571	P;B	0.58130	0.833;0.288	T	0.55218	-0.8175	10	0.02654	T	1	.	19.757000	0.962980	0.0:0.0:1.0:0.0	.	814;814	P50851;P50851-2	LRBA_HUMAN;.	E	814	ENSP00000446299:Q814E;ENSP00000421552:Q814E;ENSP00000349629:Q814E;ENSP00000422180:Q814E	ENSP00000349629:Q814E	Q	-	1	0	LRBA	152011136	1	0.714170	1	0.803570	9.870000e-01	0.754690	5.464000	0.667190	2.678000	0.912160	0.460000	0.390300	CAA		TCGA-HZ-7922-01A-11D-2154-08	LRBA-002	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000364939.1	1	0	1	126	200	0	82	1	9.998105e-01	15	9	0	82	2		0	0	0	0	0	2	1	1.000000	125	199	0	82	2								-20.000000	1	1	0	0		1	0	2	2	1.773460	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
GOLPH3	64083	broad.mit.edu	37	5	32126388	32126388	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr5:32126388G>A	ENST00000265070.6	-	4	1142	c.827C>T	c.(826-828)cCt>cTt	p.P276L	GOLPH3_ENST00000512668.1_5'Flank	NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)			11					TTCCACTTCAGGGTCTAAGTC	0.542000																								0							SO:0001583	missense			ENST00000265070.6	1	1	hg19	CCDS3896.1	.	.	.	.	.	.	.	.	.	.	G	6.769000	0.510717	0.128830	.	.	ENSG00000113384	ENST00000265070;ENST00000542582	.	.	.	6.170000	6.170000	0.997090	.	0.000000	0.85682	D	0.000000	T	0.65101	0.2659	L	0.51422	1.61	0.807220	D	1.000000	B	0.24963	0.115	B	0.31614	0.133	T	0.58803	-0.7572	9	0.11485	T	0.65	.	20.879400	0.998670	0.0:0.0:1.0:0.0	.	276	Q9H4A6	GOLP3_HUMAN	L	276;259	.	ENSP00000265070:P276L	P	-	2	0	GOLPH3	32162145	1	0.714170	9.660000e-01	0.408740	1.000000e-02	0.072450	9.414000	0.973620	2.941000	0.997820	0.655000	0.942530	CCT		TCGA-HZ-7922-01A-11D-2154-08	GOLPH3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000207363.2	1	0	1	172	444	0	75	1	1	112	290	0	75	2		0	0	0	0	0	2	1	1.000000	168	439	0	74	2								-8.599169	1	1	0	0		1	2	2	4	2.353196	1	0.370000	2.950000	0.540146	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
LPA	4018	broad.mit.edu	37	6	161032642	161032642	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr6:161032642G>C	ENST00000316300.5	-	16	2599	c.2555C>G	c.(2554-2556)tCt>tGt	p.S852C	LPA_ENST00000447678.1_Missense_Mutation_p.S852C			P08519	APOA_HUMAN	lipoprotein, Lp(a)			107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		Aminocaproic Acid(DB00513)	TGGTGTCATAGATGACCAAGC	0.493000																								0							SO:0001583	missense			ENST00000316300.5	0	1	hg19	CCDS43523.1	.	.	.	.	.	.	.	.	.	.	g	10.020000	1.236595	0.227110	.	.	ENSG00000198670	ENST00000316300;ENST00000447678	T;T	0.67698	-0.28;-0.28	2.170000	2.170000	0.276980	Kringle (4);Kringle-like fold (1);	.	.	.	.	D	0.83589	0.5287	H	0.99238	4.48	0.200740	N	0.999939	D	0.61697	0.99	D	0.81914	0.995	T	0.72228	-0.4354	9	0.66056	D	0.02	.	7.828200	0.293280	0.0:0.0:1.0:0.0	.	3360	P08519	APOA_HUMAN	C	852	ENSP00000321334:S852C;ENSP00000395608:S852C	ENSP00000321334:S852C	S	-	2	0	LPA	160952632	9.440000e-01	0.320720	2.680000e-01	0.245710	2.680000e-01	0.265110	4.700000	0.618030	1.217000	0.434420	0.194000	0.174250	TCT		TCGA-HZ-7922-01A-11D-2154-08	LPA-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000042957.1	0	0	0	21	1302	0	275		0	0	0	0	275	2		0	0	0	0	0	2	1	0.999988	18	1122	0	459	2								-3.319111	1	1	0	0		1	0	2	2	1.723553	1	0.370000	2.950000	0.370000	0.080000	0.040000	0.130000	0.080000	0.089614	0.080000	0	6.000000e-02	1.100000e-01
FLNC	2318	broad.mit.edu	37	7	128477594	128477594	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr7:128477594A>G	ENST00000325888.8	+	4	1103	c.842A>G	c.(841-843)tAt>tGt	p.Y281C	FLNC_ENST00000346177.6_Missense_Mutation_p.Y281C	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma			128					GCCATCGCCTATGGGCCTGGT	0.602000																								0							SO:0001583	missense			ENST00000325888.8	1	1	hg19	CCDS43644.1	.	.	.	.	.	.	.	.	.	.	A	19.490000	3.837735	0.713730	.	.	ENSG00000128591	ENST00000325888;ENST00000346177	D;D	0.85013	-1.93;-1.93	5.390000	5.390000	0.778230	Immunoglobulin E-set (1);Immunoglobulin-like fold (1);	0.000000	0.85682	D	0.000000	D	0.94185	0.8134	H	0.94542	3.55	0.496870	D	0.999814	D;D	0.89917	1.0;1.0	D;D	0.91635	0.999;0.994	D	0.95461	0.8543	10	0.87932	D	0	.	13.379500	0.607590	1.0:0.0:0.0:0.0	.	281;281	Q14315-2;Q14315	.;FLNC_HUMAN	C	281	ENSP00000327145:Y281C;ENSP00000344002:Y281C	ENSP00000327145:Y281C	Y	+	2	0	FLNC	128264830	1	0.714170	1	0.803570	9.530000e-01	0.610140	5.922000	0.700360	2.043000	0.605330	0.533000	0.621200	TAT		TCGA-HZ-7922-01A-11D-2154-08	FLNC-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000059948.3	1	0	1	137	222	0	87	1	9.996751e-01	9	14	0	87	2		0	0	0	0	0	2	1	1.000000	135	218	0	87	2								-20.000000	1	1	0	0		1	0	2	2	1.717328	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
TNRC18	84629	broad.mit.edu	37	7	5410273	5410273	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr7:5410273C>T	ENST00000430969.1	-	11	4300	c.3952G>A	c.(3952-3954)Ggc>Agc	p.G1318S	TNRC18_ENST00000399537.4_Missense_Mutation_p.G1318S	NM_001080495.2	NP_001073964.2	O15417	TNC18_HUMAN	trinucleotide repeat containing 18			11		Ovarian(82;0.142)			CAGGTGCTGCCGAGTACAGGC	0.662000																								0							SO:0001583	missense			ENST00000430969.1	1	1	hg19	CCDS47534.1	.	.	.	.	.	.	.	.	.	.	C	4.209000	0.037484	0.081480	.	.	ENSG00000182095	ENST00000399537;ENST00000430969;ENST00000399544;ENST00000327499	T;T	0.10668	2.85;2.85	4.900000	-0.334000	0.126660	.	0.390991	0.18787	N	0.131164	T	0.05686	0.0149	N	0.25144	0.715	0.093100	N	1.000000	B	0.10296	0.003	B	0.08055	0.003	T	0.33343	-0.9872	10	0.32370	T	0.25	.	4.691000	0.127810	0.0:0.5034:0.1509:0.3457	.	1318	O15417	TNC18_HUMAN	S	1318;1318;373;373	ENSP00000382452:G1318S;ENSP00000395538:G1318S	ENSP00000330383:G373S	G	-	1	0	TNRC18	5376799	0	0.058580	2.000000e-03	0.105220	8.500000e-02	0.179050	-0.185000	0.096840	0.146000	0.190020	0.313000	0.208870	GGC		TCGA-HZ-7922-01A-11D-2154-08	TNRC18-201	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding		1	0	1	29	46	0	26	1	9.999999e-01	34	22	0	26	2		0	0	0	0	0	2	1	1.000000	29	46	0	25	2								-7.264140	1	1	120846	1	24	1	0	2	2	1.688928	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	0.999997	0.990000	1	9.900000e-01	1
GDF6	392255	broad.mit.edu	37	8	97156945	97156945	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr8:97156945G>A	ENST00000287020.5	-	2	1313	c.1214C>T	c.(1213-1215)aCg>aTg	p.T405M		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6			27	Breast(36;2.67e-05)				GTTCATCAGCGTCTGGATGAT	0.602000																								0							SO:0001583	missense			ENST00000287020.5	1	1	hg19	CCDS34926.1	.	.	.	.	.	.	.	.	.	.	G	24.400000	4.526943	0.857060	.	.	ENSG00000156466	ENST00000287020	D	0.89617	-2.54	4.950000	4.950000	0.653090	Transforming growth factor-beta, C-terminal (3);	0.000000	0.85682	D	0.000000	D	0.95118	0.8418	M	0.87381	2.88	0.807220	D	1.000000	D	0.89917	1.0	D	0.97110	1.0	D	0.95756	0.8796	10	0.87932	D	0	.	17.142600	0.867580	0.0:0.0:1.0:0.0	.	405	Q6KF10	GDF6_HUMAN	M	405	ENSP00000287020:T405M	ENSP00000287020:T405M	T	-	2	0	GDF6	97226121	1	0.714170	1	0.803570	9.960000e-01	0.888480	9.595000	0.982600	2.567000	0.866030	0.650000	0.862430	ACG		TCGA-HZ-7922-01A-11D-2154-08	GDF6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000379862.2	1	0	1	34	185	0	29	0	4.827448e-01	0	10	0	29	2		0	0	0	0	0	2	1	1.000000	32	180	0	28	2								-18.159600	1	1	0	0		1	2	4	6	2.947154	1	0.370000	2.950000	0.636385	0.990000	0.990000	1.000000	1.000000	0.999261	0.990000	1	9.900000e-01	1
SH2D3C	10044	broad.mit.edu	37	9	130507114	130507114	+	Missense_Mutation	SNP	G	G	A	rs142472912	by1000genomes	TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			G	A	G	G		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chr9:130507114G>A	ENST00000314830.8	-	7	1642	c.1529C>T	c.(1528-1530)gCg>gTg	p.A510V	SH2D3C_ENST00000429553.1_Missense_Mutation_p.A156V|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373274.3_Missense_Mutation_p.A350V|SH2D3C_ENST00000420366.1_Missense_Mutation_p.A352V|SH2D3C_ENST00000373277.4_Missense_Mutation_p.A353V|SH2D3C_ENST00000373276.3_Missense_Mutation_p.A442V	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C			28					GGTCTCAGTCGCTGCCCACTC	0.627000																								0							SO:0001583	missense			ENST00000314830.8	1	1	hg19	CCDS6877.1	1	4.578754578754579E-4	0	0.0	0	0.0	0	0.0	1	0.0013192612137203166	G	10.210000	1.288019	0.234780	.	.	ENSG00000095370	ENST00000373277;ENST00000420366;ENST00000373276;ENST00000373274;ENST00000429553;ENST00000314830	T;T;T;T;T;T	0.41065	1.01;1.01;1.01;1.01;1.01;1.01	5.500000	2.400000	0.295150	.	0.589560	0.17839	N	0.160278	T	0.27765	0.0683	L	0.44542	1.39	0.093100	N	1.000000	B;B;B;B;B	0.33494	0.217;0.414;0.059;0.324;0.032	B;B;B;B;B	0.22152	0.038;0.017;0.002;0.038;0.003	T	0.13388	-1.0511	10	0.45353	T	0.12	-3.8094	6.123900	0.201670	0.074:0.134:0.6533:0.1387	.	350;510;442;353;352	E9PG48;Q8N5H7;E7EUN5;Q8N5H7-2;Q8N5H7-5	.;SH2D3_HUMAN;.;.;.	V	353;352;442;350;156;510	ENSP00000362374:A353V;ENSP00000388536:A352V;ENSP00000362373:A442V;ENSP00000362371:A350V;ENSP00000394632:A156V;ENSP00000317817:A510V	ENSP00000317817:A510V	A	-	2	0	SH2D3C	129546935	4.800000e-02	0.203560	6.000000e-03	0.133840	5.040000e-01	0.338890	2.309000	0.436990	0.640000	0.305820	0.462000	0.415740	GCG		TCGA-HZ-7922-01A-11D-2154-08	SH2D3C-004	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000054264.1	1	0	1	328	609	0	209	0	9.999261e-01	0	29	0	209	2		0	0	0	0	0	2	1	1.000000	322	599	0	206	2								-20.000000	1	1	121412	4	42	1	0	2	2	1.706660	1	0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
AMOT	154796	broad.mit.edu	37	X	112048283	112048283	+	Silent	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chrX:112048283C>T	ENST00000524145.1	-	6	1742	c.1668G>A	c.(1666-1668)gcG>gcA	p.A556A	AMOT_ENST00000304758.1_Silent_p.A147A|AMOT_ENST00000371962.1_Silent_p.A324A|AMOT_ENST00000371959.3_Silent_p.A556A|AMOT_ENST00000371958.1_Silent_p.A324A			Q4VCS5	AMOT_HUMAN	angiomotin			43					TGGCCAGCTCCGCTTCCAGCT	0.527000																								0							SO:0001819	synonymous_variant			ENST00000524145.1	1	1	hg19	CCDS48154.1																																																																																				TCGA-HZ-7922-01A-11D-2154-08	AMOT-005	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000378570.1	1	0	1	454	725	0	201	1	9.991171e-01	12	8	0	201	2		0	0	0	0	0	2	1	1.000000	452	715	0	200	2								-20.000000	1	1	121410	8	45	1	0	1	1			0.370000	2.950000	0.370000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
ACE2	59272	broad.mit.edu	37	X	15582310	15582310	+	Missense_Mutation	SNP	G	G	A	rs144869363	byFrequency	TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chrX:15582310G>A	ENST00000252519.3	-	17	2248	c.2146C>T	c.(2146-2148)Cgt>Tgt	p.R716C	ACE2_ENST00000427411.1_Missense_Mutation_p.R716C|ACE2_ENST00000471548.1_5'UTR			Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2			32	Hepatocellular(33;0.183)			Lisinopril(DB00722)|Moexipril(DB00691)	TCATTCAGACGGAAAGCATCA	0.428000																								0							SO:0001583	missense			ENST00000252519.3	1	1	hg19	CCDS14169.1	.	.	.	.	.	.	.	.	.	.	G	10.330000	1.320166	0.239940	2.61E-4	0.0	ENSG00000130234	ENST00000252519;ENST00000427411	D;D	0.85484	-1.99;-1.99	6.160000	0.081700	0.144250	.	0.653399	0.16598	N	0.207475	D	0.84325	0.5447	M	0.77616	2.38	0.093100	N	1.000000	D	0.56287	0.975	P	0.46339	0.513	T	0.76586	-0.2905	10	0.87932	D	0	1.1293	7.436300	0.271580	0.0666:0.5122:0.2256:0.1956	.	716	Q9BYF1	ACE2_HUMAN	C	716	ENSP00000252519:R716C;ENSP00000389326:R716C	ENSP00000252519:R716C	R	-	1	0	ACE2	15492231	2.930000e-01	0.243710	2.000000e-03	0.105220	4.000000e-03	0.042600	0.501000	0.225780	-0.455000	0.070540	-1.092000	0.021720	CGT		TCGA-HZ-7922-01A-11D-2154-08	ACE2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055867.1	1	0	1	128	573	0	133	0	3.388481e-02	1	1	0	133	2		0	0	0	0	0	2	1	1.000000	129	570	0	131	2								-2.902241	1	1	0	0		1	0	1	1			0.370000	2.950000	0.370000	0.980000	0.830000	1.000000	1.000000	0.962861	0.980000	1	9.000000e-01	1
NLGN3	54413	broad.mit.edu	37	X	70389792	70389792	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7922-01A-11D-2154-08	TCGA-HZ-7922-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bbc4c64-410c-4e0c-b04f-1e5a4bbc57dd	e7c35b8d-64c7-479b-8b92-8afb9a6d23d0	g.chrX:70389792C>T	ENST00000358741.3	+	8	2695	c.2392C>T	c.(2392-2394)Cgc>Tgc	p.R798C	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.R758C|NLGN3_ENST00000374051.3_Missense_Mutation_p.R778C	NM_181303.1	NP_851820.1	Q9NZ94	NLGN3_HUMAN	neuroligin 3	p.R778C(1)		37	Renal(35;0.156)				GACCCTGCGGCGCTCCCCGGA	0.612000													Esophageal Squamous(103;760 1488 16849 22250 40351)											1	Substitution - Missense(1)						SO:0001583	missense			ENST00000358741.3	1	1	hg19	CCDS55441.1	.	.	.	.	.	.	.	.	.	.	C	17.270000	3.346340	0.610730	.	.	ENSG00000196338	ENST00000536169;ENST00000374051;ENST00000358741	T;T;T	0.73258	-0.7;-0.73;-0.73	4.920000	4.920000	0.645770	.	0.000000	0.85682	D	0.000000	D	0.82907	0.5139	M	0.79123	2.44	0.807220	D	1.000000	D;D;D	0.89917	0.999;0.999;1.0	D;D;D	0.76071	0.97;0.97;0.987	D	0.85078	0.0944	10	0.87932	D	0	.	12.562700	0.562910	0.1658:0.8342:0.0:0.0	.	758;798;778	D3DVV1;Q9NZ94;Q9NZ94-2	.;NLGN3_HUMAN;.	C	758;778;798	ENSP00000445298:R758C;ENSP00000363163:R778C;ENSP00000351591:R798C	ENSP00000351591:R798C	R	+	1	0	NLGN3	70306517	1	0.714170	1	0.803570	9.460000e-01	0.594870	3.794000	0.554920	2.310000	0.778750	0.525000	0.510460	CGC		TCGA-HZ-7922-01A-11D-2154-08	NLGN3-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000057121.1	1	0	1	16	42	0	14	0	5.357265e-01	0	6	0	14	2		0	0	0	0	0	2	1	0.999971	16	41	0	14	2								-20.000000	1	1	0	0		1	0	1	1			0.370000	2.950000	0.370000	0.990000	0.920000	1.000000	1.000000	0.995380	0.990000	1	9.900000e-01	1