Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
SGK1	6446	broad.mit.edu	37	6	134491968	134491973	+	In_Frame_Del	DEL	TTTGGG	TTTGGG	-			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08			TTTGGG	-	TTTGGG	TTTGGG		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr6:134491968_134491973delTTTGGG	ENST00000237305.7	-	11	1207_1212	c.1119_1124delCCCAAA	c.(1117-1125)aacccaaat>aat	p.373_375NPN>N	SGK1_ENST00000413996.3_In_Frame_Del_p.387_389NPN>N|SGK1_ENST00000367858.5_In_Frame_Del_p.468_470NPN>N|SGK1_ENST00000489458.2_5'Flank|SGK1_ENST00000475719.2_In_Frame_Del_p.329_331NPN>N|SGK1_ENST00000528577.1_In_Frame_Del_p.401_403NPN>N|SGK1_ENST00000367857.5_In_Frame_Del_p.363_365NPN>N	NM_005627.3	NP_005618.2	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1			46	Colorectal(23;0.221)				ACTCACCACATTTGGGTTAAAAGGGG	0.388000																								0							SO:0001651	inframe_deletion			ENST00000237305.7	1	1	hg19	CCDS5170.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	SGK1-009	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000042312.2	0	0	0	24	670	0	123	1	9.986496e-01	4	282	0	123	2	0	0	0	0	0	0		1	0.462010	45	687	2	125	27								-19.954690	1	1	0	0		1	0	0	0	1.966951	0	0.130000	1.930000	0.106776	0.510000	0.340000	0.740000	0.510000	0.531754	0.510000	0	0.420000	0.630000
MMP13	4322	broad.mit.edu	37	11	102816457	102816457	+	Silent	SNP	A	A	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr11:102816457A>T	ENST00000260302.3	-	9	1261	c.1233T>A	c.(1231-1233)atT>atA	p.I411I	MMP13_ENST00000340273.4_Silent_p.I411I	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)			27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		Marimastat(DB00786)	CTTTATCCATAATATGGTTAG	0.303000																								0							SO:0001819	synonymous_variant			ENST00000260302.3	1	1	hg19	CCDS8324.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	MMP13-001	NOVEL	basic|appris_principal|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000386648.1	1	0	0	16	191	0	28	0	6.971975e-03	0	2	0	28	2		0	0	0	0	0	2	1	0.999937	16	188	0	28	2								-19.990060	1	1	0	0		1	0	0	0	1.968664	0	0.130000	1.930000	0.107967	0.990000	0.680000	1.000000	1.000000	0.959584	0.990000	1	0.890000	1.000000
CCDC88B	283234	broad.mit.edu	37	11	64116904	64116904	+	Silent	SNP	G	G	C			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr11:64116904G>C	ENST00000356786.5	+	15	2762	c.2718G>C	c.(2716-2718)ctG>ctC	p.L906L	CCDC88B_ENST00000301897.4_5'UTR|CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000359902.2_Silent_p.L58L	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B			27					AGGAATTTCTGCGAGAAAAGG	0.652000																								0							SO:0001819	synonymous_variant			ENST00000356786.5	1	1	hg19	CCDS8072.2																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	CCDC88B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000104845.1	1	0	1	13	91	0	30	0	6.562683e-01	1	16	0	30	2		0	0	0	0	0	2	1	0.999576	12	89	0	30	2								-19.957820	1	1	0	0		1	0	0	0	1.974689	0	0.130000	1.930000	0.110338	0.990000	0.920000	1.000000	1.000000	0.995370	0.990000	1	0.990000	1.000000
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr12:25398284C>T	ENST00000256078.4	-	2	98	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	0	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	23.4	4.409094	0.83340	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78595	-1.19;-1.19;-1.19;-1.19	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.85919	0.5809	M	0.91818	3.245	0.80722	D	1	B;P	0.35714	0.385;0.517	B;B	0.41619	0.257;0.361	D	0.87870	0.2670	10	0.87932	D	0	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	D	12	ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D	ENSP00000256078:G12D	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-HV-A5A5-01A-11D-A26I-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	0	7	91	0	12	0	1.998835e-02	1	2	0	12	2	1	9.999987e-01	41	533	0	422	2	1	0.981909	7	91	0	11	2								-5.317441	1	1	121404	2	44	1	1	2	3	2.024156	0	0.130000	1.930000	0.137290	0.990000	0.520000	1.000000	1.000000	0.928016	0.990000	1	0.790000	1.000000
ADAMTS20	80070	broad.mit.edu	37	12	43886398	43886398	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr12:43886398G>A	ENST00000389420.3	-	6	985	c.986C>T	c.(985-987)aCa>aTa	p.T329I	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.T329I	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20			95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)			GTTCTTTAATGTGGTAGCACC	0.363000																								0							SO:0001583	missense			ENST00000389420.3	1	1	hg19	CCDS31778.2	.	.	.	.	.	.	.	.	.	.	G	16.01	3.000515	0.54147	.	.	ENSG00000173157	ENST00000389420;ENST00000553158;ENST00000389417	T;T	0.65916	-0.18;-0.18	4.79	4.79	0.61399	Metallopeptidase, catalytic domain (1);Peptidase M12B, ADAM/reprolysin (2);	0.000000	0.50627	D	0.000108	D	0.83880	0.5350	M	0.91354	3.2	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.87771	0.2605	10	0.87932	D	0	.	18.7307	0.91734	0.0:0.0:1.0:0.0	.	329	P59510	ATS20_HUMAN	I	329	ENSP00000374071:T329I;ENSP00000448341:T329I	ENSP00000374068:T329I	T	-	2	0	ADAMTS20	42172665	1.000000	0.71417	0.633000	0.29310	0.037000	0.13140	9.136000	0.94489	2.587000	0.87381	0.557000	0.71058	ACA		TCGA-HV-A5A5-01A-11D-A26I-08	ADAMTS20-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000403643.1	1	0	0	10	114	0	32		0	0	0	0	32	2		0	0	0	0	0	2	1	0.996901	10	111	0	32	2								-15.198080	1	1	0	0		1	1	2	3	2.024156	0	0.130000	1.930000	0.137290	0.990000	0.660000	1.000000	1.000000	0.966191	0.990000	1	0.940000	1.000000
KBTBD6	89890	broad.mit.edu	37	13	41705969	41705969	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr13:41705969G>A	ENST00000379485.1	-	1	913	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C	KBTBD6_ENST00000499385.2_Missense_Mutation_p.R161C	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6			43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)			CTATCCAAGCGCAGGACAGCC	0.577000																								0							SO:0001583	missense			ENST00000379485.1	1	1	hg19	CCDS9376.1	.	.	.	.	.	.	.	.	.	.	g	8.936	0.964565	0.18583	.	.	ENSG00000165572	ENST00000379485;ENST00000499385	T;T	0.69926	-0.44;-0.44	3.69	2.84	0.33178	BTB/Kelch-associated (2);	0.403521	0.25071	N	0.033363	T	0.53465	0.1798	L	0.47716	1.5	0.39301	D	0.964912	B;B	0.16396	0.013;0.017	B;B	0.12156	0.006;0.007	T	0.52177	-0.8610	10	0.46703	T	0.11	.	4.7523	0.13066	0.1156:0.0:0.6731:0.2113	.	161;227	F5GZN7;Q86V97	.;KBTB6_HUMAN	C	227;161	ENSP00000368799:R227C;ENSP00000444326:R161C	ENSP00000368799:R227C	R	-	1	0	KBTBD6	40603969	0.993000	0.37304	0.992000	0.48379	0.726000	0.41606	0.964000	0.29306	0.891000	0.36235	0.462000	0.41574	CGC		TCGA-HV-A5A5-01A-11D-A26I-08	KBTBD6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000044657.1	0	0	0	16	466	0	91	0	6.645258e-02	0	12	0	91	2		0	0	0	0	0	2	1	0.999933	15	465	0	90	2								-3.234467	1	1	121412	1	37	1	1	2	3	2.131836	1	0.130000	1.930000	0.183099	0.550000	0.320000	0.840000	0.540000	0.569963	0.550000	0	0.420000	0.700000
NEK5	341676	broad.mit.edu	37	13	52661584	52661584	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr13:52661584G>A	ENST00000355568.4	-	15	1421	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	p.R485G(1)|p.R428G(1)		39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)			GAAGATGGACGAAGACCCTAT	0.343000																								2	Substitution - Missense(2)						SO:0001583	missense			ENST00000355568.4	1	1	hg19	CCDS31979.1	.	.	.	.	.	.	.	.	.	.	G	15.71	2.913462	0.52439	.	.	ENSG00000197168	ENST00000355568	T	0.79247	-1.25	5.45	2.83	0.33086	.	0.000000	0.64402	D	0.000003	D	0.84061	0.5389	M	0.65498	2.005	0.33027	D	0.529691	D	0.89917	1.0	D	0.91635	0.999	D	0.85308	0.1077	10	0.87932	D	0	.	7.7703	0.29004	0.2616:0.0:0.7384:0.0	.	428	Q6P3R8	NEK5_HUMAN	C	428	ENSP00000347767:R428C	ENSP00000347767:R428C	R	-	1	0	NEK5	51559585	1.000000	0.71417	0.992000	0.48379	0.707000	0.40811	1.885000	0.39678	0.286000	0.22352	-0.812000	0.03155	CGT		TCGA-HV-A5A5-01A-11D-A26I-08	NEK5-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000045045.3	1	0	0	18	401	0	43	0	0	0	1	0	43	2		0	0	0	0	0	2	1	0.999979	18	392	0	43	2								-3.006531	1	1	121412	1	29	1	1	2	3	2.131836	1	0.130000	1.930000	0.183099	0.710000	0.430000	1.000000	1.000000	0.726107	0.710000	0	0.560000	0.890000
PCK2	5106	broad.mit.edu	37	14	24569250	24569250	+	Silent	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr14:24569250C>T	ENST00000216780.4	+	7	1330	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	PCK2_ENST00000545054.2_Silent_p.A220A|PCK2_ENST00000558096.1_Silent_p.A220A|NRL_ENST00000561028.1_Intron|PCK2_ENST00000396973.4_Silent_p.A354A|PCK2_ENST00000561286.1_Silent_p.A220A|PCK2_ENST00000559250.1_Silent_p.A366A	NM_004563.2	NP_004554.2	Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)			18					TTGGGGTTGCCCCTGGTACCT	0.502000																								0							SO:0001819	synonymous_variant			ENST00000216780.4	1	1	hg19	CCDS9609.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	PCK2-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000071900.3	1	0	1	101	655	0	130	1	9.995625e-01	27	47	0	130	2		0	0	0	0	0	2	1	1.000000	100	654	0	129	2								-3.221884	1	1	0	0		1	1	2	3	2.111925	1	0.130000	1.930000	0.183099	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	0.990000	1.000000
VKORC1	79001	broad.mit.edu	37	16	31102595	31102595	+	Missense_Mutation	SNP	C	C	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr16:31102595C>A	ENST00000394975.2	-	3	579	c.352G>T	c.(352-354)Gtc>Ttc	p.V118F	VKORC1_ENST00000319788.7_Missense_Mutation_p.C145F|VKORC1_ENST00000354895.4_Missense_Mutation_p.C81F|RP11-196G11.1_ENST00000529564.1_Intron|VKORC1_ENST00000394971.3_Missense_Mutation_p.C149F|PRSS53_ENST00000280606.6_5'Flank|VKORC1_ENST00000300851.6_Missense_Mutation_p.C138F|VKORC1_ENST00000498155.1_Missense_Mutation_p.C150F	NM_024006.4	NP_076869.1	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1			4				Acenocoumarol(DB01418)|Dicoumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	GCCAGGTAGACAGAACCAGCG	0.557000																								0							SO:0001583	missense			ENST00000394975.2	1	1	hg19	CCDS10703.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	C|C	16.16|16.16	3.045854|3.045854	0.55110|0.55110	.|.	.|.	ENSG00000167397|ENSG00000167397	ENST00000300851;ENST00000319788;ENST00000354895;ENST00000394971;ENST00000498155|ENST00000394975	D;D;D|D	0.98120|0.98264	-4.39;-4.73;-4.09|-4.83	5.92|5.92	-3.16|-3.16	0.05217|0.05217	.|Vitamin K epoxide reductase (2);	.|0.619698	.|0.14857	.|N	.|0.294303	D|D	0.95204|0.95204	0.8445|0.8445	.|.	.|.	.|.	0.09310|0.09310	N|N	0.999999|0.999999	B;B|B	0.30824|0.16603	0.296;0.128|0.018	B;B|B	0.29785|0.22152	0.107;0.035|0.038	T|T	0.82508|0.82508	-0.0422|-0.0422	8|8	0.87932|.	D|.	0|.	-15.2501|-15.2501	18.204|18.204	0.89848|0.89848	0.0:0.1877:0.7473:0.065|0.0:0.1877:0.7473:0.065	.|.	145;81|118	Q9BQB6-2;A6NIQ6|Q9BQB6	.;.|VKOR1_HUMAN	F|F	138;145;81;149;150|118	ENSP00000300851:C138F;ENSP00000326135:C145F;ENSP00000346969:C81F|ENSP00000378426:V118F	ENSP00000300851:C138F|.	C|V	-|-	2|1	0|0	VKORC1|VKORC1	31010096|31010096	0.565000|0.565000	0.26610|0.26610	0.676000|0.676000	0.29932|0.29932	0.976000|0.976000	0.68499|0.68499	0.092000|0.092000	0.15066|0.15066	-0.397000|-0.397000	0.07691|0.07691	-0.244000|-0.244000	0.11960|0.11960	TGT|GTC		TCGA-HV-A5A5-01A-11D-A26I-08	VKORC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000108582.1	1	0	0	9	131	0	32	1	9.999965e-01	39	419	0	32	2		0	0	0	0	0	2	1	0.994528	9	130	0	32	2								-13.191870	1	1	0	0		1	1	2	3	2.051020	0	0.130000	1.930000	0.142815	0.990000	0.530000	1.000000	1.000000	0.917441	0.990000	1	0.760000	1.000000
MT1B	4490	broad.mit.edu	37	16	56686964	56686964	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr16:56686964G>A	ENST00000334346.2	+	3	228	c.173G>A	c.(172-174)cGc>cAc	p.R58H	RP11-249C24.11_ENST00000568608.1_RNA|MT1B_ENST00000562399.1_Silent_p.P57P	NM_005947.2	NP_005938.1	P07438	MT1B_HUMAN	metallothionein 1B			4					GAGAAGTGCCGCTGCTGTGCC	0.542000																								0							SO:0001583	missense			ENST00000334346.2	1	1	hg19	CCDS10765.1	.	.	.	.	.	.	.	.	.	.	G	7.922	0.738792	0.15642	.	.	ENSG00000169688	ENST00000334346	T	0.09911	2.93	3.06	0.876	0.19138	Metallothionein domain, vertebrate (1);Metallothionein domain (1);	0.285648	0.28140	U	0.016444	T	0.07413	0.0187	.	.	.	0.80722	D	1	P	0.39116	0.66	B	0.32762	0.152	T	0.24693	-1.0153	9	0.87932	D	0	.	5.4103	0.16344	0.1233:0.2054:0.6713:0.0	.	58	P07438	MT1B_HUMAN	H	58	ENSP00000334998:R58H	ENSP00000334998:R58H	R	+	2	0	MT1B	55244465	1.000000	0.71417	0.895000	0.35142	0.011000	0.07611	1.851000	0.39338	0.104000	0.17725	-0.279000	0.10071	CGC		TCGA-HV-A5A5-01A-11D-A26I-08	MT1B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257057.2	1	0	0	42	497	0	109	0	0	0	1	0	109	2		0	0	0	0	0	2	1	1.000000	40	496	0	109	2								-10.311070	1	1	121412	5	41	1	1	2	3	2.035249	0	0.130000	1.930000	0.139508	0.990000	0.890000	1.000000	1.000000	0.993707	0.990000	1	0.990000	1.000000
SPNS3	201305	broad.mit.edu	37	17	4356344	4356344	+	Silent	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr17:4356344C>T	ENST00000355530.2	+	8	1237	c.957C>T	c.(955-957)ggC>ggT	p.G319G	SPNS3_ENST00000333476.2_Silent_p.G192G|SPNS3_ENST00000576069.1_3'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)			28					TCATGACCGGCGTCATTGGGG	0.567000																								0							SO:0001819	synonymous_variant			ENST00000355530.2	1	1	hg19	CCDS11045.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	SPNS3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000438793.1	0	0	0	22	492	0	85	0	3.696631e-02	0	7	0	85	2		0	0	0	0	0	2	1	0.999999	21	486	0	85	2								-4.199964	1	1	121412	7	41	1	0	1	1	1.916031	0	0.130000	1.930000	0.070811	0.610000	0.390000	0.870000	0.600000	0.624284	0.610000	0	0.490000	0.740000
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	T	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr17:7578235T>A	ENST00000269305.4	-	6	803	c.614A>T	c.(613-615)tAt>tTt	p.Y205F	TP53_ENST00000445888.2_Missense_Mutation_p.Y205F|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.Y205F|TP53_ENST00000420246.2_Missense_Mutation_p.Y205F|TP53_ENST00000359597.4_Missense_Mutation_p.Y205F|TP53_ENST00000413465.2_Missense_Mutation_p.Y205F	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	p.Y205C(68)|p.Y205S(14)|p.Y205F(8)|p.0?(8)|p.Y112C(5)|p.?(5)|p.Y73C(5)|p.Y73S(1)|p.Y112S(1)|p.E204fs*39(1)|p.E204_N210delEYLDDRN(1)		24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		Acetylsalicylic acid(DB00945)	GTCATCCAAATACTCCACACG	0.542000		111	Mis, N, F		breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			Pancreas(47;798 1329 9957 10801)	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		L, E, M, O	117	Substitution - Missense(102)|Whole gene deletion(8)|Unknown(5)|Deletion - In frame(1)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	ENST00000269305.4	1	1	hg19	CCDS11118.1	.	.	.	.	.	.	.	.	.	.	T	20.3	3.966153	0.74131	.	.	ENSG00000141510	ENST00000413465;ENST00000359597;ENST00000269305;ENST00000455263;ENST00000420246;ENST00000445888;ENST00000396473;ENST00000545858;ENST00000509690;ENST00000514944;ENST00000414315	D;D;D;D;D;D;D;D	0.99856	-7.21;-7.21;-7.21;-7.21;-7.21;-7.21;-7.21;-7.21	5.41	4.33	0.51752	p53, DNA-binding domain (1);p53-like transcription factor, DNA-binding (1);p53/RUNT-type transcription factor, DNA-binding domain (1);	0.000000	0.85682	D	0.000000	D	0.99837	0.9926	M	0.88906	2.99	0.54753	D	0.999982	D;D;D;D;D;D;D	0.69078	0.962;0.996;0.99;0.996;0.995;0.986;0.997	D;D;D;D;D;D;D	0.76071	0.946;0.984;0.966;0.979;0.987;0.979;0.969	D	0.97337	0.9954	10	0.87932	D	0	-5.8058	9.707	0.40222	0.0:0.0827:0.0:0.9173	.	166;205;205;112;205;205;205	B4E095;P04637-2;P04637-3;E9PFT5;P04637;Q1MSW8;E7EQX7	.;.;.;.;P53_HUMAN;.;.	F	205;205;205;205;205;205;194;112;73;112;73	ENSP00000410739:Y205F;ENSP00000352610:Y205F;ENSP00000269305:Y205F;ENSP00000398846:Y205F;ENSP00000391127:Y205F;ENSP00000391478:Y205F;ENSP00000425104:Y73F;ENSP00000423862:Y112F	ENSP00000269305:Y205F	Y	-	2	0	TP53	7518960	1.000000	0.71417	0.137000	0.22149	0.045000	0.14185	7.996000	0.88334	1.001000	0.39076	-0.256000	0.11100	TAT		TCGA-HV-A5A5-01A-11D-A26I-08	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367397.1	1	0	1	19	182	0	42	1	9.738842e-01	22	38	0	42	2	1	1	109	1467	0	1380	2	1	0.999993	19	181	0	42	2								-20.000000	1	1	0	0		1	0	1	1	1.916031	0	0.130000	1.930000	0.070811	0.920000	0.680000	1.000000	1.000000	0.910877	0.920000	1	0.810000	1.000000
CD226	10666	broad.mit.edu	37	18	67614045	67614045	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr18:67614045C>T	ENST00000280200.4	-	3	575	c.307G>A	c.(307-309)Gtt>Att	p.V103I	CD226_ENST00000581982.1_Intron|CD226_ENST00000577287.1_Intron|CD226_ENST00000582621.1_Missense_Mutation_p.V103I	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule			24		Esophageal squamous(42;0.129)			TAGTAGCCAACATCATCTTCA	0.418000													NSCLC(184;838 2130 8673 21498 50749)											0							SO:0001583	missense			ENST00000280200.4	1	1	hg19	CCDS11997.1	.	.	.	.	.	.	.	.	.	.	C	4.746	0.138729	0.09083	.	.	ENSG00000150637	ENST00000280200	T	0.64803	-0.12	5.51	0.462	0.16695	Immunoglobulin V-set (1);Immunoglobulin-like (1);Immunoglobulin-like fold (1);	0.314578	0.33916	N	0.004434	T	0.31606	0.0802	N	0.05510	-0.035	0.09310	N	1	B	0.20368	0.044	B	0.20577	0.03	T	0.13124	-1.0521	10	0.14252	T	0.57	.	4.3927	0.11348	0.0:0.4783:0.1594:0.3623	.	103	Q15762	CD226_HUMAN	I	103	ENSP00000280200:V103I	ENSP00000280200:V103I	V	-	1	0	CD226	65765025	0.000000	0.05858	0.009000	0.14445	0.442000	0.32017	-0.509000	0.06336	0.077000	0.16863	0.655000	0.94253	GTT		TCGA-HV-A5A5-01A-11D-A26I-08	CD226-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256226.3	1	0	0	13	195	0	37	0	4.739336e-03	0	2	0	37	2		0	0	0	0	0	2	1	0.999585	13	195	0	36	2								-5.560943	1	1	0	0		1	0	0	0	1.818857	1	0.130000	1.930000	0.033226	0.410000	0.290000	1.000000	0.450000	0.426184	0.410000	0	0.360000	0.450000
LRFN1	57622	broad.mit.edu	37	19	39804836	39804836	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr19:39804836C>T	ENST00000248668.4	-	1	1140	c.1141G>A	c.(1141-1143)Gcg>Acg	p.A381T	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1			18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)		TCCACGGGCGCCGTCGCTTCC	0.692000																								0							SO:0001583	missense			ENST00000248668.4	0	1	hg19	CCDS46071.1	.	.	.	.	.	.	.	.	.	.	C	17.94	3.510446	0.64522	.	.	ENSG00000128011	ENST00000248668	T	0.68624	-0.34	4.53	4.53	0.55603	Immunoglobulin I-set (1);Immunoglobulin-like (1);Immunoglobulin-like fold (1);	0.000000	0.44483	D	0.000444	T	0.65923	0.2738	N	0.25286	0.73	0.58432	D	0.999998	P	0.46952	0.887	P	0.55391	0.775	T	0.66492	-0.5910	10	0.40728	T	0.16	.	14.7902	0.69837	0.0:1.0:0.0:0.0	.	381	Q9P244	LRFN1_HUMAN	T	381	ENSP00000248668:A381T	ENSP00000248668:A381T	A	-	1	0	LRFN1	44496676	0.996000	0.38824	0.615000	0.29064	0.472000	0.32918	2.624000	0.46444	2.352000	0.79861	0.655000	0.94253	GCG		TCGA-HV-A5A5-01A-11D-A26I-08	LRFN1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000463835.1	0	0	0	7	203	0	36	0	1.451090e-02	0	5	0	36	2		0	0	0	0	0	2	1	0.980810	7	202	0	35	2								-9.365681	1	1	121162	1	24	1	1	8	9	2.882683	1	0.130000	1.930000	0.386719	0.800000	0.350000	1.000000	1.000000	0.782030	0.800000	0	0.540000	1.000000
PSG4	5672	broad.mit.edu	37	19	43702149	43702149	+	Splice_Site	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr19:43702149G>A	ENST00000405312.3	-	3	946	c.709C>T	c.(709-711)Cca>Tca	p.P237S	PSG4_ENST00000244295.9_Splice_Site_p.H237Y|PSG4_ENST00000433626.2_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	p.P237T(1)|p.H237N(1)		24		Prostate(69;0.00682)			GGATACTCACGGAGGAGATTC	0.527000																								2	Substitution - Missense(2)						SO:0001630	splice_region_variant			ENST00000405312.3	0	1	hg19	CCDS46093.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	g|g	4.459|4.459	0.085043|0.085043	0.08583|0.08583	.|.	.|.	ENSG00000243137|ENSG00000243137	ENST00000244295|ENST00000405312	T|T	0.34667|0.59772	1.35|0.24	1.96|1.96	-0.726|-0.726	0.11170|0.11170	.|Immunoglobulin-like (1);	.|.	.|.	.|.	.|.	T|T	0.44973|0.44973	0.1319|0.1319	L|L	0.49126|0.49126	1.545|1.545	0.09310|0.09310	N|N	1|1	B|B	0.06786|0.18310	0.001|0.027	B|B	0.08055|0.19946	0.003|0.027	T|T	0.32188|0.32188	-0.9916|-0.9916	9|9	0.02654|0.31617	T|T	1|0.26	.|.	4.4957|4.4957	0.11835|0.11835	0.6207:0.0:0.3793:0.0|0.6207:0.0:0.3793:0.0	.|.	237|237	Q00888-2|Q00888	.|PSG4_HUMAN	Y|S	237|237	ENSP00000244295:H237Y|ENSP00000384770:P237S	ENSP00000244295:H237Y|ENSP00000384770:P237S	H|P	-|-	1|1	0|0	PSG4|PSG4	48393989|48393989	0.003000|0.003000	0.15002|0.15002	0.008000|0.008000	0.14137|0.14137	0.006000|0.006000	0.05464|0.05464	-1.087000|-1.087000	0.03383|0.03383	-0.365000|-0.365000	0.08076|0.08076	-1.218000|-1.218000	0.01608|0.01608	CAT|CCA		TCGA-HV-A5A5-01A-11D-A26I-08	PSG4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000323073.1	0	0	0	84	1125	0	250	0	4.972261e-03	0	2	0	250	2		0	0	0	0	0	2	1	1.000000	44	484	0	364	2								-3.142702	1	1	119230	4	39	1	1	2	3	2.094941	0	0.130000	1.930000	0.152047	0.990000	0.890000	1.000000	1.000000	0.991620	0.990000	1	0.990000	1.000000
NOTCH2	4853	broad.mit.edu	37	1	120458964	120458964	+	Missense_Mutation	SNP	C	C	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr1:120458964C>G	ENST00000256646.2	-	34	6600	c.6381G>C	c.(6379-6381)aaG>aaC	p.K2127N		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2			158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)			TCCTACTACCCTTGGCATCCT	0.507000			N, F, Mis		marginal zone lymphoma, DLBCL				Alagille Syndrome						Dom	yes		1	1p13-p11	4853	Notch homolog 2		L	0							SO:0001583	missense	Familial Cancer Database	ALGS1, ALGS2.Alagille-Watson syndrome	ENST00000256646.2	0	1	hg19	CCDS908.1	.	.	.	.	.	.	.	.	.	.	C	11.90	1.777249	0.31411	.	.	ENSG00000134250	ENST00000256646	D	0.83250	-1.7	5.5	4.59	0.56863	.	0.000000	0.39615	U	0.001310	T	0.69557	0.3124	M	0.61703	1.905	0.44012	D	0.996729	B	0.14438	0.01	B	0.10450	0.005	T	0.70934	-0.4737	10	0.51188	T	0.08	.	9.6325	0.39787	0.0:0.8419:0.0:0.1581	.	2127	Q04721	NOTC2_HUMAN	N	2127	ENSP00000256646:K2127N	ENSP00000256646:K2127N	K	-	3	2	NOTCH2	120260487	0.996000	0.38824	1.000000	0.80357	0.791000	0.44710	0.961000	0.29267	1.320000	0.45209	0.561000	0.74099	AAG		TCGA-HV-A5A5-01A-11D-A26I-08	NOTCH2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000033679.1	0	0	0	8	576	0	61	1	3.937036e-01	4	86	0	61	2		0	0	0	0	0	2	1	0.988834	8	568	0	61	2								-1.867313	0	1	121412	1	34	1	1	10	11	3.169964	1	0.130000	1.930000	0.451104	0.350000	0.140000	0.640000	0.340000	0.373812	0.350000	0	0.230000	0.500000
CRKL	1399	broad.mit.edu	37	22	21272254	21272254	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr22:21272254G>A	ENST00000354336.3	+	1	541	c.32G>A	c.(31-33)cGc>cAc	p.R11H		NM_005207.3	NP_005198.1	P46109	CRKL_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog-like			14	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)		TCCTCGGACCGCTCCGCCTGG	0.692000													Pancreas(85;3 1441 23889 42519 42763)											0							SO:0001583	missense			ENST00000354336.3	0	1	hg19	CCDS13785.1	.	.	.	.	.	.	.	.	.	.	G	36	5.711248	0.96821	.	.	ENSG00000099942	ENST00000354336	T	0.69806	-0.43	5.27	5.27	0.74061	SH2 motif (1);	0.000000	0.85682	D	0.000000	T	0.76666	0.4019	L	0.46885	1.475	0.80722	D	1	D	0.61697	0.99	D	0.69307	0.963	T	0.77579	-0.2535	10	0.59425	D	0.04	.	16.742	0.85462	0.0:0.0:1.0:0.0	.	11	P46109	CRKL_HUMAN	H	11	ENSP00000346300:R11H	ENSP00000346300:R11H	R	+	2	0	CRKL	19602254	1.000000	0.71417	1.000000	0.80357	0.990000	0.78478	7.444000	0.80532	2.627000	0.88993	0.650000	0.86243	CGC		TCGA-HV-A5A5-01A-11D-A26I-08	CRKL-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000320158.1	0	0	0	4	158	0	26	0	1.717032e-01	0	24	0	26	2		0	0	0	0	0	2	1	0.886926	4	155	0	26	2								-6.110456	1	1	121404	1	30	1	0	1	1	1.923762	0	0.130000	1.930000	0.092852	0.390000	0.130000	0.810000	0.340000	0.422157	0.390000	0	0.230000	0.590000
LRRTM4	80059	broad.mit.edu	37	2	77746270	77746270	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr2:77746270C>T	ENST00000409093.1	-	3	1061	c.725G>A	c.(724-726)cGc>cAc	p.R242H	LRRTM4_ENST00000409911.1_Missense_Mutation_p.R243H|LRRTM4_ENST00000409282.1_Missense_Mutation_p.R243H|LRRTM4_ENST00000409884.1_Missense_Mutation_p.R242H|LRRTM4_ENST00000409088.3_Missense_Mutation_p.R242H			Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	p.R242H(2)		64					GCTAATGGAGCGAATCCTGTT	0.448000																								2	Substitution - Missense(2)						SO:0001583	missense			ENST00000409093.1	0	1	hg19	CCDS46346.1	.	.	.	.	.	.	.	.	.	.	C	15.50	2.853202	0.51270	.	.	ENSG00000176204	ENST00000409911;ENST00000409884;ENST00000409093;ENST00000409088;ENST00000409282	T;T;T;T;T	0.59224	0.28;0.28;0.28;0.28;0.28	5.93	5.93	0.95920	.	0.133674	0.50627	D	0.000114	T	0.66036	0.2749	N	0.25031	0.7	0.44570	D	0.997532	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.74348	0.97;0.949;0.983	T	0.68112	-0.5495	10	0.62326	D	0.03	.	18.9104	0.92481	0.0:1.0:0.0:0.0	.	243;242;242	Q4KMX1;Q86VH4-2;Q86VH4	.;.;LRRT4_HUMAN	H	243;242;242;242;243	ENSP00000387228:R243H;ENSP00000387297:R242H;ENSP00000386357:R242H;ENSP00000386236:R242H;ENSP00000386286:R243H	ENSP00000386236:R242H	R	-	2	0	LRRTM4	77599778	0.966000	0.33281	1.000000	0.80357	0.997000	0.91878	1.999000	0.40806	2.798000	0.96311	0.655000	0.94253	CGC		TCGA-HV-A5A5-01A-11D-A26I-08	LRRTM4-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000328225.1	1	0	1	11	91	0	23	0	0	0	1	0	23	2		0	0	0	0	0	2	1	0.998645	11	91	0	23	2								-17.516960	1	1	0	0		1	0	0	0	1.969198	0	0.130000	1.930000	0.107967	0.990000	0.790000	1.000000	1.000000	0.985182	0.990000	1	0.990000	1.000000
WNT7A	7476	broad.mit.edu	37	3	13860786	13860786	+	Silent	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr3:13860786G>A	ENST00000285018.4	-	4	1009	c.705C>T	c.(703-705)gcC>gcT	p.A235A		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A			24					CCACGTGAACGGCCTCGTTGT	0.622000																								0							SO:0001819	synonymous_variant			ENST00000285018.4	1	1	hg19	CCDS2616.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	WNT7A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252031.2	0	0	0	17	444	0	77	0	7.909401e-02	0	12	0	77	2		0	0	0	0	0	2	1	0.999965	17	441	0	76	2								-3.208233	1	1	121412	6	36	1	0	0	0	1.987976	0	0.130000	1.930000	0.116213	0.560000	0.340000	0.840000	0.550000	0.578882	0.560000	0	0.440000	0.710000
HRASLS	57110	broad.mit.edu	37	3	192988436	192988436	+	Missense_Mutation	SNP	T	T	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr3:192988436T>A	ENST00000602513.1	+	4	858	c.449T>A	c.(448-450)gTt>gAt	p.V150D	HRASLS_ENST00000264735.2_Missense_Mutation_p.V255D			Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor			10	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)		ACAGCTGCTGTTGGTGTCTTC	0.378000																								0							SO:0001583	missense			ENST00000602513.1	1	1	hg19		.	.	.	.	.	.	.	.	.	.	T	15.20	2.763169	0.49574	.	.	ENSG00000127252	ENST00000264735	.	.	.	5.64	2.63	0.31362	.	0.234074	0.43416	D	0.000571	T	0.24967	0.0606	N	0.14661	0.345	0.42689	D	0.99357	P	0.43169	0.8	B	0.32289	0.143	T	0.05801	-1.0863	9	0.54805	T	0.06	-6.1788	10.6667	0.45734	0.0:0.8466:0.0:0.1534	.	150	Q9HDD0	HRSL1_HUMAN	D	150	.	ENSP00000264735:V150D	V	+	2	0	HRASLS	194471130	0.958000	0.32768	0.982000	0.44146	0.968000	0.65278	2.072000	0.41510	0.359000	0.24239	-0.263000	0.10527	GTT		TCGA-HV-A5A5-01A-11D-A26I-08	HRASLS-201	KNOWN	basic|appris_principal	protein_coding	protein_coding		0	0	0	13	382	0	43	0	1.329063e-03	0	2	0	43	2		0	0	0	0	0	2	1	0.999487	13	374	0	42	2								-13.017070	1	1	0	0		1	0	0	0	1.988754	0	0.130000	1.930000	0.117379	0.500000	0.280000	0.800000	0.490000	0.524492	0.500000	0	0.380000	0.650000
ANK2	287	broad.mit.edu	37	4	114277476	114277476	+	Missense_Mutation	SNP	T	T	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr4:114277476T>G	ENST00000357077.4	+	38	7755	c.7702T>G	c.(7702-7704)Tgt>Ggt	p.C2568G	ANK2_ENST00000264366.6_Missense_Mutation_p.C2535G|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal			248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)			GATTCATGAATGTGCAGAGGA	0.433000																								0							SO:0001583	missense			ENST00000357077.4	1	1	hg19	CCDS3702.1	.	.	.	.	.	.	.	.	.	.	T	17.40	3.379860	0.61845	.	.	ENSG00000145362	ENST00000357077;ENST00000264366	T;T	0.66815	-0.22;-0.23	5.81	5.81	0.92471	.	0.222920	0.31542	N	0.007467	T	0.69061	0.3069	L	0.60455	1.87	0.80722	D	1	B;P	0.50272	0.001;0.933	B;P	0.49829	0.002;0.623	T	0.69774	-0.5054	9	.	.	.	.	11.6148	0.51083	0.0:0.0:0.2662:0.7338	.	2535;2568	Q01484;Q01484-4	ANK2_HUMAN;.	G	2568;2535	ENSP00000349588:C2568G;ENSP00000264366:C2535G	.	C	+	1	0	ANK2	114496925	1.000000	0.71417	0.975000	0.42487	0.993000	0.82548	4.953000	0.63624	2.216000	0.71823	0.533000	0.62120	TGT		TCGA-HV-A5A5-01A-11D-A26I-08	ANK2-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000256422.2	1	0	0	53	576	0	82		0	0	0	0	82	2		0	0	0	0	0	2	1	1.000000	53	569	0	81	2								-20.000000	1	1	0	0		1	0	0	0	1.984973	0	0.130000	1.930000	0.115044	0.990000	0.960000	1.000000	1.000000	0.997839	0.990000	1	0.990000	1.000000
ANKRD50	57182	broad.mit.edu	37	4	125592599	125592599	+	Silent	SNP	A	A	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr4:125592599A>G	ENST00000504087.1	-	4	2870	c.1833T>C	c.(1831-1833)ggT>ggC	p.G611G	ANKRD50_ENST00000515641.1_Silent_p.G432G	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50			55					ATGCTGTCCAACCATCTTGAT	0.453000																								0							SO:0001819	synonymous_variant			ENST00000504087.1	1	1	hg19	CCDS34060.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	ANKRD50-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000364775.1	0	0	0	19	492	0	84	0	1.292811e-01	0	16	0	84	2		0	0	0	0	0	2	1	0.999990	19	485	0	84	2								-18.046860	1	1	0	0		1	0	0	0	1.984973	0	0.130000	1.930000	0.115044	0.560000	0.350000	0.830000	0.560000	0.580667	0.560000	0	0.440000	0.700000
CDKN2AIP	55602	broad.mit.edu	37	4	184368445	184368445	+	Silent	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr4:184368445C>T	ENST00000504169.1	+	3	1815	c.1608C>T	c.(1606-1608)ctC>ctT	p.L536L	CDKN2AIP_ENST00000302350.4_3'UTR	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein			6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)			AGTTATTTCTCAAGAAAAAGG	0.383000																								0							SO:0001819	synonymous_variant			ENST00000504169.1	1	1	hg19	CCDS34110.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	CDKN2AIP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000361488.1	1	0	1	33	442	0	62	1	9.178054e-01	13	46	0	62	2		0	0	0	0	0	2	1	1.000000	33	441	0	62	2								-3.075755	1	1	0	0		1	0	0	0	1.984973	0	0.130000	1.930000	0.115044	0.990000	0.730000	1.000000	1.000000	0.957813	0.990000	1	0.880000	1.000000
CDH10	1008	broad.mit.edu	37	5	24505322	24505322	+	Missense_Mutation	SNP	A	A	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr5:24505322A>G	ENST00000264463.4	-	8	1799	c.1292T>C	c.(1291-1293)aTc>aCc	p.I431T		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)			185					AATGTTAAAGATTCTGTCAAG	0.368000										HNSCC(23;0.051)														0							SO:0001583	missense			ENST00000264463.4	1	1	hg19	CCDS3892.1	.	.	.	.	.	.	.	.	.	.	A	16.20	3.056941	0.55325	.	.	ENSG00000040731	ENST00000264463	T	0.50548	0.74	5.57	5.57	0.84162	Cadherin (4);Cadherin-like (1);	0.053511	0.64402	D	0.000001	T	0.46210	0.1381	L	0.49640	1.575	0.46241	D	0.998949	B	0.21606	0.058	B	0.26202	0.067	T	0.41070	-0.9529	10	0.52906	T	0.07	.	14.9114	0.70761	1.0:0.0:0.0:0.0	.	431	Q9Y6N8	CAD10_HUMAN	T	431	ENSP00000264463:I431T	ENSP00000264463:I431T	I	-	2	0	CDH10	24541079	1.000000	0.71417	1.000000	0.80357	0.996000	0.88848	7.096000	0.76960	2.102000	0.63906	0.533000	0.62120	ATC		TCGA-HV-A5A5-01A-11D-A26I-08	CDH10-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000207345.2	1	0	0	16	249	0	40	0	0	0	1	0	40	2		0	0	0	0	0	2	1	0.999939	16	248	0	40	2								-19.534750	1	1	0	0		1	1	2	3	2.041932	0	0.130000	1.930000	0.141165	0.990000	0.580000	1.000000	1.000000	0.909359	0.990000	1	0.760000	1.000000
TCP10	6953	broad.mit.edu	37	6	167789546	167789546	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr6:167789546C>T	ENST00000397829.4	-	6	763	c.596G>A	c.(595-597)cGa>cAa	p.R199Q	TCP10_ENST00000366827.2_Missense_Mutation_p.R199Q	NM_004610.3	NP_004601.3	Q12799	TCP10_HUMAN	t-complex 10			18		Breast(66;1.53e-05)|Ovarian(120;0.024)			TTGCGGACTTCGGGAAGATGG	0.612000																								0							SO:0001583	missense			ENST00000397829.4	0	1	hg19	CCDS43527.1	.	.	.	.	.	.	.	.	.	.	C	10.68	1.417194	0.25552	.	.	ENSG00000203690	ENST00000366827;ENST00000397829	T;T	0.12361	2.69;2.69	1.65	-1.26	0.09376	.	.	.	.	.	T	0.05914	0.0154	N	0.14661	0.345	0.09310	N	1	D;B	0.64830	0.994;0.185	P;B	0.62382	0.901;0.006	T	0.17623	-1.0363	9	0.72032	D	0.01	.	4.5266	0.11985	0.0:0.4475:0.0:0.5525	.	226;226	Q12799;Q12799-2	TCP10_HUMAN;.	Q	199	ENSP00000355792:R199Q;ENSP00000380929:R199Q	ENSP00000355792:R199Q	R	-	2	0	TCP10	167709536	0.000000	0.05858	0.000000	0.03702	0.086000	0.17979	-2.900000	0.00704	-0.317000	0.08677	0.306000	0.20318	CGA		TCGA-HV-A5A5-01A-11D-A26I-08	TCP10-008	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000365570.1	0	0	0	4	162	0	31		0	0	0	0	31	2		0	0	0	0	0	2	1	0.885531	4	158	0	34	2								-5.888731	1	0	120942	12	37	1	0	0	0	1.966951	0	0.130000	1.930000	0.106776	0.390000	0.130000	0.810000	0.340000	0.422908	0.390000	0	0.230000	0.590000
GPLD1	2822	broad.mit.edu	37	6	24450108	24450108	+	Missense_Mutation	SNP	G	G	A	rs149093201		TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr6:24450108G>A	ENST00000230036.1	-	15	1465	c.1355C>T	c.(1354-1356)tCg>tTg	p.S452L		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1			32					AGCCAAGGCCGAGCCAAACCG	0.622000																								0							SO:0001583	missense			ENST00000230036.1	1	1	hg19	CCDS4553.1	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0	G	20.6	4.024960	0.75390	0.0	2.33E-4	ENSG00000112293	ENST00000230036	T	0.69561	-0.41	5.11	5.11	0.69529	.	0.000000	0.64402	D	0.000017	T	0.73946	0.3652	M	0.69463	2.115	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	T	0.69439	-0.5145	10	0.18276	T	0.48	-12.1527	18.1339	0.89610	0.0:0.0:1.0:0.0	.	452	P80108	PHLD_HUMAN	L	452	ENSP00000230036:S452L	ENSP00000230036:S452L	S	-	2	0	GPLD1	24558087	1.000000	0.71417	0.934000	0.37439	0.948000	0.59901	6.383000	0.73172	2.368000	0.80403	0.591000	0.81541	TCG		TCGA-HV-A5A5-01A-11D-A26I-08	GPLD1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000043315.1	1	0	1	46	310	0	74	0	0	0	1	0	74	2		0	0	0	0	0	2	1	1.000000	45	310	0	74	2								-3.075738	1	1	121408	63	50	1	0	0	0	1.965585	0	0.130000	1.930000	0.106776	0.990000	0.990000	1.000000	1.000000	0.999996	0.990000	1	0.990000	1.000000
KLHL32	114792	broad.mit.edu	37	6	97424015	97424015	+	Missense_Mutation	SNP	C	C	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr6:97424015C>A	ENST00000369261.4	+	3	529	c.166C>A	c.(166-168)Cac>Aac	p.H56N	KLHL32_ENST00000544166.1_5'UTR|KLHL32_ENST00000539200.1_Missense_Mutation_p.H56N|KLHL32_ENST00000536676.1_Missense_Mutation_p.H56N	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32			38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)			ATTCCATGCTCACAAGGCAGT	0.463000																								0							SO:0001583	missense			ENST00000369261.4	1	1	hg19	CCDS5038.1	.	.	.	.	.	.	.	.	.	.	C	23.8	4.464888	0.84425	.	.	ENSG00000186231	ENST00000369261;ENST00000536676;ENST00000539200;ENST00000369254	T;T;T;T	0.79141	-1.24;1.22;1.22;-1.24	5.14	5.14	0.70334	BTB/POZ-like (2);BTB/POZ (1);BTB/POZ fold (2);	0.000000	0.85682	D	0.000000	D	0.89574	0.6754	M	0.89785	3.06	0.80722	D	1	D;P;D;D	0.89917	1.0;0.936;1.0;0.999	D;P;D;D	0.97110	0.999;0.885;1.0;0.995	D	0.91142	0.4946	10	0.87932	D	0	.	18.7846	0.91949	0.0:1.0:0.0:0.0	.	56;56;56;56	B7Z4E2;B7Z346;Q96NJ5;Q6IQ08	.;.;KLH32_HUMAN;.	N	56	ENSP00000358265:H56N;ENSP00000440382:H56N;ENSP00000441527:H56N;ENSP00000358258:H56N	ENSP00000358258:H56N	H	+	1	0	KLHL32	97530736	1.000000	0.71417	1.000000	0.80357	0.879000	0.50718	7.320000	0.79064	2.674000	0.91012	0.591000	0.81541	CAC		TCGA-HV-A5A5-01A-11D-A26I-08	KLHL32-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000041570.1	1	0	0	20	239	0	64		0	0	0	0	64	2		0	0	0	0	0	2	1	0.999996	20	238	0	64	2								-2.716743	1	1	0	0		1	0	0	0	1.966951	0	0.130000	1.930000	0.106776	0.990000	0.720000	1.000000	1.000000	0.967096	0.990000	1	0.910000	1.000000
IMPDH1	3614	broad.mit.edu	37	7	128035057	128035057	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr7:128035057G>A	ENST00000480861.1	-	11	1243	c.1166C>T	c.(1165-1167)aCg>aTg	p.T389M	IMPDH1_ENST00000354269.5_Missense_Mutation_p.T469M|IMPDH1_ENST00000343214.4_Missense_Mutation_p.T369M|IMPDH1_ENST00000348127.6_Missense_Mutation_p.T443M|IMPDH1_ENST00000419067.2_Missense_Mutation_p.T446M|IMPDH1_ENST00000338791.6_Missense_Mutation_p.T479M|IMPDH1_ENST00000470772.1_Missense_Mutation_p.T393M|IMPDH1_ENST00000378717.4_Missense_Mutation_p.T410M|IMPDH1_ENST00000496200.1_Missense_Mutation_p.T369M	NM_001142574.1	NP_001136046.1			IMP (inosine 5'-monophosphate) dehydrogenase 1			22					AGGGGCCTCCGTAGTGGCGGC	0.642000																								0							SO:0001583	missense			ENST00000480861.1	1	1	hg19	CCDS55161.1	4	0.0018315018315018315	0	0.0	0	0.0	4	0.006993006993006993	0	0.0	G	19.24	3.788614	0.70337	.	.	ENSG00000106348	ENST00000419067;ENST00000338791;ENST00000496200;ENST00000354269;ENST00000378717;ENST00000348127;ENST00000343214;ENST00000470772;ENST00000480861	T;T;T;T;T;T;T;T;T	0.79247	-1.25;-1.25;-1.25;-1.25;-1.25;-1.25;-1.25;-1.25;-1.25	4.62	4.62	0.57501	Aldolase-type TIM barrel (1);IMP dehydrogenase/GMP reductase (1);	0.000000	0.85682	D	0.000000	D	0.82641	0.5081	M	0.72894	2.215	0.80722	D	1	D;D;D;D;D;D;D;D	0.89917	1.0;0.996;0.998;0.999;0.999;0.996;0.997;0.994	D;D;D;D;D;P;P;P	0.70016	0.967;0.935;0.92;0.955;0.955;0.823;0.889;0.893	D	0.86285	0.1670	10	0.87932	D	0	-11.3859	15.0316	0.71710	0.0:0.0:1.0:0.0	.	446;389;394;410;469;443;479;369	C9JV30;B4DE09;P20839;E7EQS0;Q5H9Q6;P20839-3;A4D0Z6;P20839-2	.;.;IMDH1_HUMAN;.;.;.;.;.	M	446;479;369;469;410;443;369;393;389	ENSP00000399400:T446M;ENSP00000345096:T479M;ENSP00000420803:T369M;ENSP00000346219:T469M;ENSP00000367989:T410M;ENSP00000265385:T443M;ENSP00000342438:T369M;ENSP00000417296:T393M;ENSP00000420185:T389M	ENSP00000345096:T479M	T	-	2	0	IMPDH1	127822293	1.000000	0.71417	1.000000	0.80357	0.959000	0.62525	9.218000	0.95166	2.409000	0.81822	0.561000	0.74099	ACG		TCGA-HV-A5A5-01A-11D-A26I-08	IMPDH1-009	PUTATIVE	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000349462.1	1	0	1	28	472	0	90	1	9.440390e-01	10	73	0	90	2		0	0	0	0	0	2	1	1.000000	28	466	0	90	2								-6.281820	1	1	121412	9	41	1	1	2	3	2.046447	0	0.130000	1.930000	0.142266	0.910000	0.600000	1.000000	1.000000	0.887264	0.910000	1	0.740000	1.000000
CDK6	1021	broad.mit.edu	37	7	92462588	92462588	+	Missense_Mutation	SNP	G	G	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr7:92462588G>T	ENST00000265734.4	-	2	461	c.50C>A	c.(49-51)gCg>gAg	p.A17E	CDK6_ENST00000424848.2_Missense_Mutation_p.A17E|CDK6_ENST00000491250.1_5'Flank	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6			11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)		CCCGATCTCCGCCACGCATTC	0.721000			T	MLLT10	ALL										Dom	yes		7	7q21-q22	1021	cyclin-dependent kinase 6		L	0							SO:0001583	missense			ENST00000265734.4	0	1	hg19	CCDS5628.1	.	.	.	.	.	.	.	.	.	.	G	15.15	2.748628	0.49257	.	.	ENSG00000105810	ENST00000265734;ENST00000424848	T;T	0.39056	1.1;1.1	5.5	5.5	0.81552	Serine/threonine-protein kinase-like domain (1);Serine/threonine-protein kinase, catalytic  domain (1);Protein kinase-like domain (1);Protein kinase, catalytic domain (1);	0.000000	0.85682	D	0.000000	T	0.33527	0.0866	N	0.01219	-0.95	0.80722	D	1	D	0.89917	1.0	D	0.79108	0.992	T	0.36237	-0.9756	10	0.02654	T	1	-2.5446	19.3835	0.94546	0.0:0.0:1.0:0.0	.	17	Q00534	CDK6_HUMAN	E	17	ENSP00000265734:A17E;ENSP00000397087:A17E	ENSP00000265734:A17E	A	-	2	0	CDK6	92300524	1.000000	0.71417	1.000000	0.80357	0.916000	0.54674	9.695000	0.98691	2.586000	0.87340	0.557000	0.71058	GCG		TCGA-HV-A5A5-01A-11D-A26I-08	CDK6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000254605.2	0	0	0	5	61	0	18	0	2.480818e-02	0	3	0	18	2		0	0	0	0	0	2	1	0.940062	5	61	0	17	2								-9.778956	1	1	0	0		1	1	2	3	2.046447	0	0.130000	1.930000	0.142266	0.990000	0.490000	1.000000	1.000000	0.933182	0.990000	1	0.810000	1.000000
CDK6	1021	broad.mit.edu	37	7	92462589	92462589	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr7:92462589C>T	ENST00000265734.4	-	2	460	c.49G>A	c.(49-51)Gcg>Acg	p.A17T	CDK6_ENST00000424848.2_Missense_Mutation_p.A17T|CDK6_ENST00000491250.1_5'Flank	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6			11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)		CCGATCTCCGCCACGCATTCG	0.721000			T	MLLT10	ALL										Dom	yes		7	7q21-q22	1021	cyclin-dependent kinase 6		L	0							SO:0001583	missense			ENST00000265734.4	0	1	hg19	CCDS5628.1	.	.	.	.	.	.	.	.	.	.	C	32	5.133124	0.94517	.	.	ENSG00000105810	ENST00000265734;ENST00000424848	T;T	0.43294	0.95;0.95	5.5	5.5	0.81552	Serine/threonine-protein kinase-like domain (1);Serine/threonine-protein kinase, catalytic  domain (1);Protein kinase-like domain (1);Protein kinase, catalytic domain (1);	0.000000	0.85682	D	0.000000	T	0.45994	0.1370	N	0.21373	0.66	0.80722	D	1	D	0.60575	0.988	P	0.53490	0.727	T	0.49476	-0.8936	10	0.87932	D	0	-2.5446	19.3835	0.94546	0.0:1.0:0.0:0.0	.	17	Q00534	CDK6_HUMAN	T	17	ENSP00000265734:A17T;ENSP00000397087:A17T	ENSP00000265734:A17T	A	-	1	0	CDK6	92300525	1.000000	0.71417	1.000000	0.80357	0.919000	0.55068	7.686000	0.84128	2.586000	0.87340	0.557000	0.71058	GCG		TCGA-HV-A5A5-01A-11D-A26I-08	CDK6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000254605.2	0	0	0	5	60	0	18	0	2.551819e-02	0	3	0	18	2		0	0	0	0	0	2	1	0.940103	5	60	0	17	2								-10.160710	1	1	0	0		1	1	2	3	2.046447	0	0.130000	1.930000	0.142266	0.990000	0.500000	1.000000	1.000000	0.935920	0.990000	1	0.830000	1.000000
KIF24	347240	broad.mit.edu	37	9	34311094	34311094	+	Missense_Mutation	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr9:34311094C>T	ENST00000402558.2	-	1	275	c.251G>A	c.(250-252)cGc>cAc	p.R84H	KIF24_ENST00000345050.2_Missense_Mutation_p.R84H|KIF24_ENST00000379166.2_Missense_Mutation_p.R84H|KIF24_ENST00000379174.3_Missense_Mutation_p.R84H			Q5T7B8	KIF24_HUMAN	kinesin family member 24			32			LUSC - Lung squamous cell carcinoma(29;0.0107)		AGATTTGATGCGCAGGCTGCT	0.418000																								0							SO:0001583	missense			ENST00000402558.2	0	1	hg19	CCDS6551.2	.	.	.	.	.	.	.	.	.	.	C	0.004	-2.298945	0.00243	.	.	ENSG00000186638	ENST00000402558;ENST00000379174;ENST00000379166;ENST00000345050;ENST00000420188	T;T;T;T	0.17054	2.3;2.3;2.3;2.3	5.33	-3.11	0.05299	.	1.777690	0.03267	N	0.184207	T	0.06142	0.0159	N	0.03608	-0.345	0.09310	N	1	B;B	0.26258	0.145;0.054	B;B	0.14023	0.01;0.004	T	0.24225	-1.0166	10	0.15952	T	0.53	.	4.7677	0.13141	0.1156:0.463:0.1071:0.3143	.	84;84	Q5T7B8-4;Q5T7B8	.;KIF24_HUMAN	H	84	ENSP00000384433:R84H;ENSP00000368472:R84H;ENSP00000368464:R84H;ENSP00000340179:R84H	ENSP00000340179:R84H	R	-	2	0	KIF24	34301094	0.000000	0.05858	0.000000	0.03702	0.056000	0.15407	-0.077000	0.11394	-0.464000	0.06963	-0.312000	0.09012	CGC		TCGA-HV-A5A5-01A-11D-A26I-08	KIF24-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000052150.5	1	0	0	14	155	0	16	0	0	0	1	0	16	2		0	0	0	0	0	2	1	0.999796	14	155	0	16	2								-6.697247	1	1	120860	10	41	1	1	2	3	2.031232	0	0.130000	1.930000	0.138955	0.990000	0.760000	1.000000	1.000000	0.980917	0.990000	1	0.990000	1.000000
DOCK8	81704	broad.mit.edu	37	9	428461	428461	+	Missense_Mutation	SNP	C	C	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chr9:428461C>G	ENST00000453981.1	+	35	4550	c.4438C>G	c.(4438-4440)Cac>Gac	p.H1480D	DOCK8_ENST00000432829.2_Missense_Mutation_p.H1412D|DOCK8_ENST00000382329.1_Missense_Mutation_p.H947D|DOCK8_ENST00000469391.1_Missense_Mutation_p.H1380D			Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8			65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)			CTACCTGACTCACTGCTTTGC	0.483000																								0							SO:0001583	missense			ENST00000453981.1	1	1	hg19	CCDS6440.2	.	.	.	.	.	.	.	.	.	.	C	32	5.175582	0.94807	.	.	ENSG00000107099	ENST00000453981;ENST00000287364;ENST00000432829;ENST00000469391;ENST00000382329	T;T;T;T	0.61980	0.06;0.06;0.06;0.06	5.65	5.65	0.86999	Armadillo-type fold (1);	0.000000	0.85682	D	0.000000	T	0.81880	0.4916	M	0.89904	3.07	0.80722	D	1	D;D;D	0.58970	0.984;0.984;0.967	P;P;P	0.59221	0.805;0.854;0.808	D	0.85234	0.1034	10	0.72032	D	0.01	.	19.713	0.96103	0.0:1.0:0.0:0.0	.	1380;947;1480	E9PH09;A2A369;Q8NF50	.;.;DOCK8_HUMAN	D	1480;1448;1412;1380;947	ENSP00000408464:H1480D;ENSP00000394888:H1412D;ENSP00000419438:H1380D;ENSP00000371766:H947D	ENSP00000287364:H1448D	H	+	1	0	DOCK8	418461	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.696000	0.84270	2.648000	0.89879	0.650000	0.86243	CAC		TCGA-HV-A5A5-01A-11D-A26I-08	DOCK8-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000171792.5	1	0	0	12	181	0	35	0	4.287952e-01	0	21	0	35	2		0	0	0	0	0	2	1	0.999183	12	180	0	35	2								-2.967499	1	1	0	0		1	1	2	3	2.031232	0	0.130000	1.930000	0.138955	0.990000	0.550000	1.000000	1.000000	0.908943	0.990000	1	0.750000	1.000000
PHKA2	5256	broad.mit.edu	37	X	18956750	18956750	+	Missense_Mutation	SNP	C	C	G			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chrX:18956750C>G	ENST00000379942.4	-	10	1701	c.1036G>C	c.(1036-1038)Gtt>Ctt	p.V346L		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)			61	Hepatocellular(33;0.183)				CTCACCTGAACAGCATCACCA	0.368000																								0							SO:0001583	missense			ENST00000379942.4	1	1	hg19	CCDS14190.1	.	.	.	.	.	.	.	.	.	.	c	13.19	2.163684	0.38217	.	.	ENSG00000044446	ENST00000379942	D	0.92805	-3.11	4.53	3.65	0.41850	Six-hairpin glycosidase-like (1);Glycoside hydrolase 15-related (1);	0.184470	0.46145	N	0.000306	D	0.85457	0.5701	L	0.38175	1.15	0.38841	D	0.956057	B	0.02656	0.0	B	0.08055	0.003	T	0.78961	-0.1997	10	0.41790	T	0.15	-9.3948	6.1366	0.20237	0.0:0.6738:0.1786:0.1476	.	346	P46019	KPB2_HUMAN	L	346	ENSP00000369274:V346L	ENSP00000369274:V346L	V	-	1	0	PHKA2	18866671	0.974000	0.33945	0.709000	0.30452	0.843000	0.47879	3.060000	0.49955	0.809000	0.34255	0.597000	0.82753	GTT		TCGA-HV-A5A5-01A-11D-A26I-08	PHKA2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055960.1	1	0	0	36	392	0	47	0	3.415070e-01	0	14	0	47	2		0	0	0	0	0	2	1	1.000000	36	387	0	47	2								-20.000000	1	1	0	0		1	0	1	1			0.130000	1.930000	0.130000	0.990000	0.920000	1.000000	1.000000	0.995721	0.990000	1	0.990000	1.000000
MAP3K15	389840	broad.mit.edu	37	X	19392682	19392682	+	Missense_Mutation	SNP	G	G	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chrX:19392682G>A	ENST00000338883.4	-	20	2685	c.2686C>T	c.(2686-2688)Cgt>Tgt	p.R896C	MAP3K15_ENST00000359173.3_Missense_Mutation_p.R331C|MAP3K15_ENST00000469203.2_Missense_Mutation_p.R728C|Y_RNA_ENST00000365274.1_RNA|MAP3K15_ENST00000518578.1_5'UTR	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15			42	Hepatocellular(33;0.183)				GTGGTGGCACGTTTGTGGGGG	0.537000																								0							SO:0001583	missense			ENST00000338883.4	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	18.20	3.570696	0.65765	.	.	ENSG00000180815	ENST00000338883;ENST00000359173;ENST00000469203	T;T;T	0.72051	-0.62;-0.62;-0.62	5.56	5.56	0.83823	Serine/threonine-protein kinase-like domain (1);Serine/threonine-protein kinase, catalytic  domain (1);Protein kinase-like domain (1);Protein kinase, catalytic domain (1);	0.000000	0.85682	D	0.000000	D	0.92087	0.7492	H	0.99752	4.75	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.97110	1.0;1.0	D	0.95672	0.8724	10	0.87932	D	0	.	18.8298	0.92133	0.0:0.0:1.0:0.0	.	371;896	Q6ZN16-3;Q6ZN16	.;M3K15_HUMAN	C	896;331;728	ENSP00000345629:R896C;ENSP00000352093:R331C;ENSP00000428356:R728C	ENSP00000345629:R896C	R	-	1	0	MAP3K15	19302603	1.000000	0.71417	0.238000	0.24106	0.532000	0.34746	4.772000	0.62324	2.479000	0.83701	0.600000	0.82982	CGT		TCGA-HV-A5A5-01A-11D-A26I-08	MAP3K15-201	KNOWN	basic|appris_principal	protein_coding	protein_coding		1	0	0	26	355	0	75	0	5.113636e-03	0	2	0	75	2		0	0	0	0	0	2	1	1.000000	26	350	0	75	2								-20.000000	1	1	121410	1	35	1	0	1	1			0.130000	1.930000	0.130000	0.990000	0.700000	1.000000	1.000000	0.951523	0.990000	1	0.860000	1.000000
GPR174	84636	broad.mit.edu	37	X	78426854	78426854	+	Missense_Mutation	SNP	T	T	A			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chrX:78426854T>A	ENST00000276077.1	+	1	386	c.350T>A	c.(349-351)tTt>tAt	p.F117Y		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174			38					GTGCGACGATTTTGGTTTCTC	0.468000										HNSCC(63;0.18)														0							SO:0001583	missense			ENST00000276077.1	1	1	hg19	CCDS14443.1	.	.	.	.	.	.	.	.	.	.	t	5.465	0.270931	0.10349	.	.	ENSG00000147138	ENST00000276077	T	0.41065	1.01	5.13	5.13	0.70059	GPCR, rhodopsin-like superfamily (1);	0.056736	0.64402	D	0.000001	T	0.22126	0.0533	N	0.16567	0.415	0.33746	D	0.620086	B	0.09022	0.002	B	0.18871	0.023	T	0.23833	-1.0177	10	0.02654	T	1	.	8.9269	0.35646	0.1684:0.0:0.0:0.8315	.	117	Q9BXC1	GP174_HUMAN	Y	117	ENSP00000276077:F117Y	ENSP00000276077:F117Y	F	+	2	0	GPR174	78313510	1.000000	0.71417	1.000000	0.80357	0.969000	0.65631	3.473000	0.53122	1.697000	0.51169	0.433000	0.28618	TTT		TCGA-HV-A5A5-01A-11D-A26I-08	GPR174-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000057327.1	1	0	0	60	714	0	112	0	0	0	1	0	112	2		0	0	0	0	0	2	1	1.000000	59	709	0	112	2								-20.000000	1	1	0	0		1	0	1	1			0.130000	1.930000	0.130000	0.990000	0.920000	1.000000	1.000000	0.995207	0.990000	1	0.990000	1.000000
POF1B	79983	broad.mit.edu	37	X	84560887	84560887	+	Silent	SNP	C	C	T			TCGA-HV-A5A5-01A-11D-A26I-08	TCGA-HV-A5A5-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	750ef0d5-c92c-4c0f-98f1-c69d1f32a5ab	42147311-f42e-4455-ad47-13f586fdca52	g.chrX:84560887C>T	ENST00000262753.4	-	13	1492	c.1347G>A	c.(1345-1347)ttG>ttA	p.L449L	POF1B_ENST00000373145.3_Silent_p.L449L	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B			35					TTTTAGCCTGCAACATTGGGC	0.388000																								0							SO:0001819	synonymous_variant			ENST00000262753.4	1	1	hg19	CCDS14452.1																																																																																				TCGA-HV-A5A5-01A-11D-A26I-08	POF1B-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000057391.2	1	0	0	27	417	0	55	1	3.359192e-01	5	14	0	55	2		0	0	0	0	0	2	1	1.000000	27	411	0	55	2								-6.759467	1	1	0	0		1	0	1	1			0.130000	1.930000	0.130000	0.930000	0.630000	1.000000	1.000000	0.902860	0.930000	1	0.770000	1.000000