Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
TP53	7157	broad.mit.edu	37	17	7577131	7577132	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr17:7577131_7577132delGC	ENST00000269305.4	-	8	995_996	c.806_807delGC	c.(805-807)agcfs	p.S269fs	TP53_ENST00000445888.2_Frame_Shift_Del_p.S269fs|TP53_ENST00000574684.1_5'Flank|TP53_ENST00000455263.2_Frame_Shift_Del_p.S269fs|TP53_ENST00000420246.2_Frame_Shift_Del_p.S269fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.S269fs|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	p.0?(8)|p.S269N(4)|p.S269S(3)|p.S269_F270>I(2)|p.?(2)|p.G266_E271delGRNSFE(2)|p.S269T(2)|p.G262_S269delGNLLGRNS(2)|p.G262_F270delGNLLGRNSF(2)|p.S269fs*75(1)|p.S269fs*76(1)|p.S269fs*3(1)|p.L265_K305del41(1)|p.S269_F270insX(1)|p.E258fs*71(1)|p.S269R(1)|p.S269fs*34(1)|p.S269fs*21(1)|p.S269>XXXXX(1)|p.G262fs*2(1)		24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		Acetylsalicylic acid(DB00945)	GCACCTCAAAGCTGTTCCGTCC	0.535000		111	Mis, N, F		breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			Pancreas(47;798 1329 9957 10801)	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		L, E, M, O	38	Whole gene deletion(8)|Deletion - In frame(7)|Substitution - Missense(7)|Deletion - Frameshift(6)|Substitution - coding silent(3)|Unknown(2)|Complex - deletion inframe(2)|Insertion - Frameshift(1)|Insertion - In frame(1)|Complex - insertion inframe(1)						SO:0001589	frameshift_variant	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	ENST00000269305.4	0	1	hg19	CCDS11118.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367397.1	0	0	0	18	87	0	37	0	6.421336e-01	0	12	0	37	2								1	0.999990	19	86	0	36	2								-20.000000	1	1	0	0		1	0	1	1	1.616440	1	0.470000	1.900000	0.311420	0.550000	3.500000e-01	0.800000	0.550000	0.569284	0.550000	0	0.440000	0.680000
POM121C	100101267	broad.mit.edu	37	7	75070256	75070257	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr7:75070256_75070257insG	ENST00000257665.5	-	3	927_928	c.928_929insC	c.(928-930)cttfs	p.L310fs	POM121C_ENST00000453279.2_Frame_Shift_Ins_p.L68fs			A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C			14					CTGGCCATCAAGGAATATTTGG	0.460000																								0							SO:0001589	frameshift_variant			ENST00000257665.5	0	1	hg19																																																																																					TCGA-FB-AAPQ-01A-11D-A40W-08	POM121C-003	KNOWN	basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000343919.2	0	0	0	41	1609	0	664	0	5.524058e-02	0	15	0	664	2								1	0.999997	31	699	0	653	2								-2.323878	0	1	0	0		1	1	2	3	2.075402	0	0.470000	1.900000	0.472479	0.100000	6.000000e-02	0.150000	0.100000	0.117350	0.100000	0	0.080000	0.130000
CCDC147	0	broad.mit.edu	37	10	106166509	106166509	+	Silent	SNP	C	C	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr10:106166509C>A	ENST00000369704.3	+	15	2348	c.2214C>A	c.(2212-2214)atC>atA	p.I738I		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN				52		Colorectal(252;0.103)|Breast(234;0.122)			AGCGTCTCATCAGCAAGACTG	0.468000																								0							SO:0001819	synonymous_variant			ENST00000369704.3	0	1	hg19	CCDS31282.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	CCDC147-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000050216.1	0	0	0	6	557	0	178		0	0	0	0	178	2								1	0.964155	6	552	0	177	2								-2.596454	1	1	121412	1	31	1	1	2	3	2.085566	0	0.470000	1.900000	0.474936	0.040000	1.000000e-02	1.000000	0.040000	0.080361	0.040000	0	0.020000	0.080000
PTPRE	5791	broad.mit.edu	37	10	129877829	129877829	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr10:129877829G>T	ENST00000254667.3	+	20	2177	c.1898G>T	c.(1897-1899)gGa>gTa	p.G633V	PTPRE_ENST00000306042.5_Missense_Mutation_p.G575V|PTPRE_ENST00000419012.2_Missense_Mutation_p.G633V	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E			22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)		Alendronate(DB00630)	TGCAGTGCCGGAGCTGGGCGA	0.483000													Colon(52;977 1184 20575 41685)											0							SO:0001583	missense			ENST00000254667.3	0	1	hg19	CCDS7657.1	.	.	.	.	.	.	.	.	.	.	G	23.0	4.364034	0.82353	.	.	ENSG00000132334	ENST00000254667;ENST00000419012;ENST00000306042	T;T;T	0.73363	-0.74;-0.74;-0.74	4.65	4.65	0.58169	Protein-tyrosine phosphatase, receptor/non-receptor type (3);Protein-tyrosine/Dual-specificity phosphatase (1);	0.000000	0.85682	D	0.000000	D	0.92655	0.7666	H	0.99573	4.635	0.80722	D	1	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.91635	0.999;0.998;0.999	D	0.95911	0.8923	10	0.87932	D	0	.	18.0677	0.89396	0.0:0.0:1.0:0.0	.	633;575;633	Q5VWH4;P23469-2;P23469	.;.;PTPRE_HUMAN	V	633;633;575	ENSP00000254667:G633V;ENSP00000402337:G633V;ENSP00000303350:G575V	ENSP00000254667:G633V	G	+	2	0	PTPRE	129767819	1.000000	0.71417	0.870000	0.34147	0.831000	0.47069	9.519000	0.98025	2.560000	0.86352	0.655000	0.94253	GGA		TCGA-FB-AAPQ-01A-11D-A40W-08	PTPRE-003	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000050990.1	0	0	0	67	196	0	103	1	9.904369e-01	9	15	0	103	2								1	1.000000	67	194	0	103	2								-4.881883	1	1	0	0		1	1	2	3	2.083607	0	0.470000	1.900000	0.474936	0.990000	8.700000e-01	1.000000	1.000000	0.988363	0.990000	1	0.980000	1.000000
TMEM26	219623	broad.mit.edu	37	10	63170325	63170325	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr10:63170325A>C	ENST00000399298.3	-	6	1230	c.862T>G	c.(862-864)Ttc>Gtc	p.F288V	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26			18	Prostate(12;0.0112)				GCGGCAAAGAACACCAGCATC	0.507000																								0							SO:0001583	missense			ENST00000399298.3	0	1	hg19	CCDS41530.1	.	.	.	.	.	.	.	.	.	.	A	32	5.156036	0.94686	.	.	ENSG00000196932	ENST00000399298	.	.	.	5.95	5.95	0.96441	.	0.000000	0.85682	D	0.000000	D	0.83908	0.5356	M	0.85777	2.775	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	D	0.86486	0.1794	9	0.87932	D	0	-0.0826	16.4288	0.83833	1.0:0.0:0.0:0.0	.	288	Q6ZUK4	TMM26_HUMAN	V	288	.	ENSP00000382237:F288V	F	-	1	0	TMEM26	62840331	1.000000	0.71417	1.000000	0.80357	0.928000	0.56348	8.906000	0.92626	2.282000	0.76494	0.533000	0.62120	TTC		TCGA-FB-AAPQ-01A-11D-A40W-08	TMEM26-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000359121.1	0	0	0	45	153	0	79		0	0	0	0	79	2								1	1.000000	44	152	0	79	2								-20.000000	1	1	0	0		1	1	2	3	2.085566	0	0.470000	1.900000	0.474936	0.970000	7.400000e-01	1.000000	1.000000	0.941600	0.970000	1	0.850000	1.000000
VCL	7414	broad.mit.edu	37	10	75849902	75849902	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr10:75849902G>A	ENST00000211998.4	+	10	1392	c.1298G>A	c.(1297-1299)cGt>cAt	p.R433H	VCL_ENST00000417648.2_Intron|VCL_ENST00000478896.2_Intron|VCL_ENST00000372755.3_Missense_Mutation_p.R433H	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin		VCL/ALK(4)	20	Prostate(51;0.0112)				GACATTCTACGTTCCCTTGGG	0.408000																								0							SO:0001583	missense			ENST00000211998.4	0	1	hg19	CCDS7341.1	.	.	.	.	.	.	.	.	.	.	G	35	5.470139	0.96274	.	.	ENSG00000035403	ENST00000372755;ENST00000211998;ENST00000415462;ENST00000537043;ENST00000436396	T;T;T	0.36878	1.23;1.23;1.23	5.54	5.54	0.83059	.	0.000000	0.85682	D	0.000000	T	0.56307	0.1976	L	0.51422	1.61	0.80722	D	1	D;D;P	0.71674	0.998;0.995;0.469	D;D;B	0.71184	0.972;0.96;0.118	T	0.53885	-0.8375	10	0.52906	T	0.07	.	19.546	0.95297	0.0:0.0:1.0:0.0	.	360;433;433	F5H7T3;P18206-2;P18206	.;.;VINC_HUMAN	H	433;433;340;360;105	ENSP00000361841:R433H;ENSP00000211998:R433H;ENSP00000415489:R105H	ENSP00000211998:R433H	R	+	2	0	VCL	75519908	1.000000	0.71417	0.996000	0.52242	0.996000	0.88848	9.341000	0.97041	2.626000	0.88956	0.585000	0.79938	CGT		TCGA-FB-AAPQ-01A-11D-A40W-08	VCL-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding		0	0	0	10	393	0	153	0	2.661909e-01	0	37	0	153	2								1	0.996847	10	390	0	153	2								-3.167381	1	1	121412	1	30	1	1	2	3	2.085566	0	0.470000	1.900000	0.474936	0.100000	5.000000e-02	1.000000	0.100000	0.141780	0.100000	0	0.070000	0.160000
DYNC2H1	79659	broad.mit.edu	37	11	103006455	103006455	+	Silent	SNP	A	A	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:103006455A>G	ENST00000375735.2	+	17	2496	c.2352A>G	c.(2350-2352)ggA>ggG	p.G784G	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Silent_p.G784G	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1			33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)			TTAGACAGGGACGATTACAAT	0.318000																								0							SO:0001819	synonymous_variant			ENST00000375735.2	0	1	hg19	CCDS53701.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	DYNC2H1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000387196.1	0	0	0	33	135	0	39	1	1.056712e-01	3	0	0	39	2								1	1.000000	33	133	0	39	2								-20.000000	1	1	0	0		1	1	2	3	2.056087	0	0.470000	1.900000	0.471243	0.830000	6.000000e-01	1.000000	1.000000	0.838654	0.830000	0	0.710000	0.980000
ANKK1	255239	broad.mit.edu	37	11	113270540	113270540	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:113270540G>A	ENST00000303941.3	+	8	1943	c.1849G>A	c.(1849-1851)Gca>Aca	p.A617T		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	p.A617S(1)		29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)			AGAGAGCCACGCAAACATGGG	0.637000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000303941.3	0	1	hg19	CCDS44734.1	.	.	.	.	.	.	.	.	.	.	G	4.640	0.119014	0.08881	.	.	ENSG00000170209	ENST00000303941	T	0.25912	1.77	4.87	2.91	0.33838	Ankyrin repeat-containing domain (4);	0.343915	0.24211	N	0.040540	T	0.23886	0.0578	M	0.62266	1.93	0.09310	N	1	B	0.22414	0.069	B	0.17979	0.02	T	0.19745	-1.0296	10	0.48119	T	0.1	-3.4949	7.1624	0.25671	0.1698:0.0:0.693:0.1372	.	617	Q8NFD2	ANKK1_HUMAN	T	617	ENSP00000306678:A617T	ENSP00000306678:A617T	A	+	1	0	ANKK1	112775750	0.999000	0.42202	0.008000	0.14137	0.045000	0.14185	3.594000	0.54008	0.231000	0.21079	-1.119000	0.02030	GCA		TCGA-FB-AAPQ-01A-11D-A40W-08	ANKK1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000395830.1	0	0	0	14	51	0	15		0	0	0	0	15	2								1	0.999868	14	51	0	15	2								-20.000000	1	1	121016	1	30	1	1	2	3	2.056087	0	0.470000	1.900000	0.471243	0.920000	5.500000e-01	1.000000	1.000000	0.880126	0.920000	1	0.720000	1.000000
NCAPD3	23310	broad.mit.edu	37	11	134031774	134031774	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:134031774T>C	ENST00000534548.2	-	28	3650	c.3586A>G	c.(3586-3588)Aat>Gat	p.N1196D		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3			71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)			TCTATGAAATTCCTCTTCTGA	0.403000																								0							SO:0001583	missense			ENST00000534548.2	0	1	hg19	CCDS31723.1	.	.	.	.	.	.	.	.	.	.	T	21.8	4.196500	0.79015	.	.	ENSG00000151503	ENST00000534548;ENST00000527944;ENST00000530396	T;T;T	0.63417	-0.04;-0.04;-0.04	5.7	5.7	0.88788	Armadillo-type fold (1);	0.136711	0.64402	D	0.000004	T	0.78761	0.4334	M	0.81112	2.525	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.73708	0.981;0.974	T	0.81611	-0.0854	10	0.72032	D	0.01	-34.3963	12.4826	0.55852	0.0:0.0:0.1394:0.8606	.	1196;256	P42695;Q96FA6	CNDD3_HUMAN;.	D	1196;101;232	ENSP00000433681:N1196D;ENSP00000432532:N101D;ENSP00000435173:N232D	ENSP00000432532:N101D	N	-	1	0	NCAPD3	133536984	1.000000	0.71417	1.000000	0.80357	0.992000	0.81027	3.796000	0.55507	2.170000	0.68504	0.533000	0.62120	AAT		TCGA-FB-AAPQ-01A-11D-A40W-08	NCAPD3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000393575.2	0	0	0	30	100	0	90	0	5.126628e-01	0	7	0	90	2								1	1.000000	29	99	0	90	2								-20.000000	1	1	0	0		1	1	2	3	2.056087	0	0.470000	1.900000	0.471243	0.980000	7.000000e-01	1.000000	1.000000	0.934355	0.980000	1	0.830000	1.000000
CYP2R1	120227	broad.mit.edu	37	11	14901766	14901766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:14901766C>A	ENST00000334636.5	-	3	962	c.916G>T	c.(916-918)Gaa>Taa	p.E306*	CYP2R1_ENST00000532378.1_Nonsense_Mutation_p.E73*|CYP2R1_ENST00000526489.1_5'UTR	NM_024514.4	NP_078790.2	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R, polypeptide 1			14				Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	ATGATGAGTTCACCCACTGAG	0.393000													NSCLC(173;1584 2058 26117 29365 41534)											0							SO:0001587	stop_gained			ENST00000334636.5	0	1	hg19	CCDS7818.1	.	.	.	.	.	.	.	.	.	.	C	43	10.097504	0.99336	.	.	ENSG00000186104	ENST00000532378;ENST00000334636	.	.	.	6.17	6.17	0.99709	.	0.042761	0.85682	D	0.000000	.	.	.	.	.	.	0.80722	A	1	.	.	.	.	.	.	.	.	.	.	0.87932	D	0	.	20.8794	0.99867	0.0:1.0:0.0:0.0	.	.	.	.	X	73;306	.	ENSP00000334592:E306X	E	-	1	0	CYP2R1	14858342	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	7.818000	0.86416	2.941000	0.99782	0.655000	0.94253	GAA		TCGA-FB-AAPQ-01A-11D-A40W-08	CYP2R1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000386985.1	0	0	0	12	234	0	97	0	6.401133e-02	0	8	0	97	2								1	0.999002	11	228	0	97	2								-14.089660	1	1	0	0		1	1	2	3	2.070052	0	0.470000	1.900000	0.472479	0.210000	1.100000e-01	0.370000	0.200000	0.230707	0.210000	0	0.150000	0.290000
IFITM3	10410	broad.mit.edu	37	11	319946	319946	+	Silent	SNP	G	G	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:319946G>T	ENST00000399808.4	-	2	530	c.294C>A	c.(292-294)gcC>gcA	p.A98A	IFITM3_ENST00000526811.1_Silent_p.A77A|IFITM3_ENST00000602735.1_Silent_p.A77A|RP11-326C3.11_ENST00000602756.1_RNA|RP11-326C3.11_ENST00000508004.2_RNA|RP11-326C3.14_ENST00000602809.1_lincRNA|RP11-326C3.10_ENST00000534271.1_RNA|RP11-326C3.11_ENST00000602429.1_RNA	NM_021034.2	NP_066362.2	Q01628	IFM3_HUMAN	interferon induced transmembrane protein 3			18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)			TGGAGGCATAGGCCTGGGCCC	0.617000																								0							SO:0001819	synonymous_variant			ENST00000399808.4	0	1	hg19	CCDS41585.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	IFITM3-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000384765.1	0	0	0	55	184	0	73	1	1	528	1966	0	73	2								1	1.000000	54	182	0	103	2								-20.000000	1	1	0	0		1	1	2	3	2.070052	0	0.470000	1.900000	0.472479	0.980000	7.600000e-01	1.000000	1.000000	0.948404	0.980000	1	0.860000	1.000000
GYLTL1B	120071	broad.mit.edu	37	11	45947827	45947827	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:45947827T>C	ENST00000531526.1	+	8	1048	c.937T>C	c.(937-939)Tgt>Cgt	p.C313R	GYLTL1B_ENST00000389968.3_Missense_Mutation_p.C40R|GYLTL1B_ENST00000401752.1_Missense_Mutation_p.C313R|GYLTL1B_ENST00000529052.1_Missense_Mutation_p.C282R|GYLTL1B_ENST00000325468.5_Missense_Mutation_p.C313R|GYLTL1B_ENST00000536139.1_Missense_Mutation_p.C282R	NM_152312.3	NP_689525.3	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B			22					GCGTCTGCCTTGTGTCTGGAA	0.597000																								0							SO:0001583	missense			ENST00000531526.1	0	1	hg19	CCDS31473.1	.	.	.	.	.	.	.	.	.	.	t	20.3	3.960946	0.74016	0.0	1.16E-4	ENSG00000165905	ENST00000529052;ENST00000531526;ENST00000401752;ENST00000389968;ENST00000325468;ENST00000536139	T;T;T;T;T;T	0.62639	2.01;2.01;2.01;0.01;2.01;2.01	5.89	5.89	0.94794	.	0.000000	0.85682	D	0.000000	D	0.82664	0.5086	M	0.88105	2.93	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.91635	0.998;0.999	D	0.86089	0.1549	10	0.87932	D	0	-28.9074	16.3188	0.82938	0.0:0.0:0.0:1.0	.	282;313	E9PIZ2;Q8N3Y3	.;LARG2_HUMAN	R	282;313;313;40;313;282	ENSP00000431932:C282R;ENSP00000432869:C313R;ENSP00000385235:C313R;ENSP00000374618:C40R;ENSP00000324570:C313R;ENSP00000445044:C282R	ENSP00000324570:C313R	C	+	1	0	GYLTL1B	45904403	1.000000	0.71417	0.995000	0.50966	0.428000	0.31595	7.688000	0.84153	2.252000	0.74401	0.520000	0.50463	TGT		TCGA-FB-AAPQ-01A-11D-A40W-08	GYLTL1B-002	KNOWN	alternative_5_UTR|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000392572.1	0	0	0	55	288	0	121	1	3.180715e-01	4	3	0	121	2								1	1.000000	54	284	0	120	2								-20.000000	1	1	121412	20	45	1	1	2	3	2.070052	0	0.470000	1.900000	0.472479	0.680000	5.200000e-01	0.880000	0.690000	0.694721	0.680000	0	0.600000	0.780000
CELF1	10658	broad.mit.edu	37	11	47510453	47510453	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:47510453C>G	ENST00000358597.3	-	1	113	c.114G>C	c.(112-114)caG>caC	p.Q38H	CELF1_ENST00000361904.3_Missense_Mutation_p.Q38H|CELF1_ENST00000395290.2_Missense_Mutation_p.Q38H|CELF1_ENST00000532048.1_Missense_Mutation_p.Q65H|CELF1_ENST00000310513.5_Missense_Mutation_p.Q38H|CELF1_ENST00000531165.1_Missense_Mutation_p.Q65H|AC090559.1_ENST00000578625.1_RNA|CELF1_ENST00000395292.2_Missense_Mutation_p.Q38H			Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1			18					CAGCACCATACTGTTCGAAGA	0.473000													Pancreas(163;1949 1966 9906 43218 43785)											0							SO:0001583	missense			ENST00000358597.3	0	1	hg19	CCDS31482.1	.	.	.	.	.	.	.	.	.	.	C	21.1	4.104279	0.76983	.	.	ENSG00000149187	ENST00000395290;ENST00000358597;ENST00000395292;ENST00000310513;ENST00000361904;ENST00000531165;ENST00000532048;ENST00000530151;ENST00000528434;ENST00000525841;ENST00000543178;ENST00000535982;ENST00000526419	T;T;T;T;T;T;T;T;T;T;T;T;T	0.17528	2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27;2.27	5.69	4.77	0.60923	Nucleotide-binding, alpha-beta plait (1);RNA recognition motif domain (3);	0.056069	0.64402	D	0.000001	T	0.33000	0.0848	L	0.55481	1.735	0.48452	D	0.999654	D;D;P;P;D;P	0.67145	0.996;0.988;0.679;0.679;0.988;0.725	P;P;B;B;P;B	0.59595	0.86;0.792;0.111;0.111;0.792;0.116	T	0.06285	-1.0835	10	0.72032	D	0.01	-6.7424	14.3806	0.66908	0.0:0.9293:0.0:0.0707	.	38;65;65;38;38;38	F8W940;G5EA30;Q92879-4;Q92879-2;Q92879-3;Q92879	.;.;.;.;.;CELF1_HUMAN	H	38;38;38;38;38;65;65;38;65;38;38;65;38	ENSP00000378705:Q38H;ENSP00000351409:Q38H;ENSP00000378706:Q38H;ENSP00000308386:Q38H;ENSP00000354639:Q38H;ENSP00000436864:Q65H;ENSP00000435926:Q65H;ENSP00000433986:Q38H;ENSP00000435320:Q65H;ENSP00000436191:Q38H;ENSP00000444825:Q38H;ENSP00000438044:Q65H;ENSP00000435423:Q38H	ENSP00000308386:Q38H	Q	-	3	2	CELF1	47467029	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	2.309000	0.43699	1.402000	0.46780	0.561000	0.74099	CAG		TCGA-FB-AAPQ-01A-11D-A40W-08	CELF1-024	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000398352.1	0	0	0	6	685	0	290	0	9.560576e-03	0	14	0	290	2								1	0.964284	6	680	0	285	2								-3.009632	1	1	0	0		1	1	2	3	2.070052	0	0.470000	1.900000	0.472479	0.030000	0	0.090000	0.040000	0.052285	0.030000	0	0.010000	0.060000
NRXN2	9379	broad.mit.edu	37	11	64419602	64419602	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:64419602G>A	ENST00000377551.1	-	12	2652	c.2441C>T	c.(2440-2442)gCg>gTg	p.A814V	NRXN2_ENST00000265459.6_Missense_Mutation_p.A814V|NRXN2_ENST00000377559.3_Missense_Mutation_p.A774V|NRXN2_ENST00000409571.1_Missense_Mutation_p.A807V|AP001092.4_ENST00000433606.1_RNA			Q9P2S2	NRX2A_HUMAN	neurexin 2			71					CTTGTGCCCCGCAAACAGCGT	0.572000																								0							SO:0001583	missense			ENST00000377551.1	0	1	hg19	CCDS8077.1	.	.	.	.	.	.	.	.	.	.	G	17.55	3.417206	0.62511	.	.	ENSG00000110076	ENST00000377551;ENST00000377559;ENST00000265459;ENST00000345863;ENST00000409571	T;T;T;T	0.78924	-1.22;-1.22;-1.22;-1.22	4.91	4.91	0.64330	Concanavalin A-like lectin/glucanase (1);Concanavalin A-like lectin/glucanase, subgroup (1);Laminin G domain (2);Laminin G, subdomain 2 (1);	0.000000	0.42053	U	0.000778	T	0.68274	0.2983	L	0.37897	1.145	0.47659	D	0.999482	P;P;P	0.47545	0.897;0.871;0.643	B;B;B	0.37833	0.151;0.259;0.101	T	0.73789	-0.3872	10	0.54805	T	0.06	.	15.6201	0.76799	0.0:0.0:1.0:0.0	.	774;814;560	Q9P2S2-2;Q9P2S2;E7EV67	.;NRX2A_HUMAN;.	V	814;774;814;774;807	ENSP00000366774:A814V;ENSP00000366782:A774V;ENSP00000265459:A814V;ENSP00000386416:A807V	ENSP00000265459:A814V	A	-	2	0	NRXN2	64176178	1.000000	0.71417	1.000000	0.80357	0.991000	0.79684	4.259000	0.58828	2.553000	0.86117	0.561000	0.74099	GCG		TCGA-FB-AAPQ-01A-11D-A40W-08	NRXN2-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000104967.3	0	0	0	27	91	0	45		0	0	0	0	45	2								1	1.000000	26	88	0	45	2								-3.627770	1	1	121412	7	41	1	1	2	3	2.056087	0	0.470000	1.900000	0.471243	0.970000	6.800000e-01	1.000000	1.000000	0.927633	0.970000	1	0.810000	1.000000
USP35	57558	broad.mit.edu	37	11	77919947	77919947	+	Silent	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr11:77919947G>A	ENST00000529308.1	+	9	1791	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	USP35_ENST00000530267.1_Silent_p.T78T|USP35_ENST00000441408.2_Silent_p.T96T|USP35_ENST00000530535.1_Intron|USP35_ENST00000526425.1_Silent_p.T241T	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35			23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)		CATCCTGGACGCCCTGGTTCA	0.622000																								0							SO:0001819	synonymous_variant			ENST00000529308.1	0	1	hg19	CCDS41693.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	USP35-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000390026.1	0	0	0	132	402	0	175	1	3.603632e-01	2	3	0	175	2								1	1.000000	130	396	0	175	2								-20.000000	1	1	120992	6	41	1	1	2	3	2.056087	0	0.470000	1.900000	0.471243	0.990000	8.900000e-01	1.000000	1.000000	0.988999	0.990000	1	0.970000	1.000000
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr12:25398284C>T	ENST00000256078.4	-	2	98	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	0	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	23.4	4.409094	0.83340	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78595	-1.19;-1.19;-1.19;-1.19	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.85919	0.5809	M	0.91818	3.245	0.80722	D	1	B;P	0.35714	0.385;0.517	B;B	0.41619	0.257;0.361	D	0.87870	0.2670	10	0.87932	D	0	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	D	12	ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D	ENSP00000256078:G12D	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-FB-AAPQ-01A-11D-A40W-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	0	0	0	45	142	0	102	1	9.998213e-01	25	20	0	102	2								1	1.000000	45	141	0	102	2								-20.000000	1	1	121404	2	44	1	1	2	3	2.097227	0	0.470000	1.900000	0.477369	0.990000	7.900000e-01	1.000000	1.000000	0.967915	0.990000	1	0.910000	1.000000
NOD2	64127	broad.mit.edu	37	16	50745137	50745137	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr16:50745137C>T	ENST00000300589.2	+	4	1420	c.1315C>T	c.(1315-1317)Cgc>Tgc	p.R439C	RP11-327F22.6_ENST00000602304.1_RNA	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2			52		all_cancers(37;0.0156)			GAAGTACATCCGCACCGAGTT	0.622000																								0							SO:0001583	missense			ENST00000300589.2	0	1	hg19	CCDS10746.1	.	.	.	.	.	.	.	.	.	.	C	7.462	0.644800	0.14451	0.0	1.16E-4	ENSG00000167207	ENST00000526417;ENST00000300589	T	0.79033	-1.23	5.26	3.25	0.37280	.	0.304254	0.28871	N	0.013868	T	0.72867	0.3514	M	0.65975	2.015	0.39682	D	0.97091	B;B;B	0.21606	0.05;0.058;0.046	B;B;B	0.21151	0.02;0.033;0.027	T	0.68880	-0.5292	10	0.54805	T	0.06	.	8.3773	0.32451	0.0:0.792:0.0:0.208	.	223;412;439	D6CHF9;Q9HC29-2;Q9HC29	.;.;NOD2_HUMAN	C	412;439	ENSP00000300589:R439C	ENSP00000300589:R439C	R	+	1	0	NOD2	49302638	0.028000	0.19301	0.001000	0.08648	0.212000	0.24457	0.734000	0.26101	0.562000	0.29204	0.561000	0.74099	CGC		TCGA-FB-AAPQ-01A-11D-A40W-08	NOD2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256876.2	0	0	0	79	250	0	99	0	0	0	1	0	99	2								1	1.000000	77	246	0	98	2								-4.049446	1	1	121408	8	42	1	1	2	3	2.083182	0	0.470000	1.900000	0.474936	0.990000	8.300000e-01	1.000000	1.000000	0.975749	0.990000	1	0.930000	1.000000
SLC12A4	6560	broad.mit.edu	37	16	67980419	67980419	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr16:67980419G>A	ENST00000316341.3	-	18	2499	c.2359C>T	c.(2359-2361)Cgg>Tgg	p.R787W	SLC12A4_ENST00000338335.3_Intron|LCAT_ENST00000264005.5_5'Flank|SLC12A4_ENST00000541864.2_Missense_Mutation_p.R756W|SLC12A4_ENST00000572037.1_Missense_Mutation_p.R739W|SLC12A4_ENST00000537830.2_Missense_Mutation_p.R781W|SLC12A4_ENST00000576616.1_Missense_Mutation_p.R787W|CTC-479C5.17_ENST00000590594.1_lincRNA|SLC12A4_ENST00000422611.2_Missense_Mutation_p.R789W	NM_001145961.1|NM_005072.4	NP_001139433.1|NP_005063.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4			29		Ovarian(137;0.192)		Bumetanide(DB00887)|Potassium Chloride(DB00761)	GAGTTATGCCGCATGCCTCCC	0.652000																								0							SO:0001583	missense			ENST00000316341.3	0	1	hg19	CCDS10855.1	.	.	.	.	.	.	.	.	.	.	G	18.93	3.728223	0.69074	0.0	1.16E-4	ENSG00000124067	ENST00000422611;ENST00000541864;ENST00000537830;ENST00000316341	D;D;D;D	0.92595	-3.07;-3.07;-3.07;-3.07	4.57	2.23	0.28157	.	0.048575	0.85682	D	0.000000	D	0.94837	0.8332	M	0.80982	2.52	0.80722	D	1	D;D;D;D;D;D	0.63046	0.989;0.986;0.992;0.992;0.992;0.986	P;P;D;P;P;P	0.63381	0.877;0.582;0.914;0.761;0.828;0.582	D	0.93878	0.7168	10	0.87932	D	0	.	11.329	0.49465	0.0:0.0:0.3051:0.6949	.	789;787;756;781;787;787	F5H3C0;B4DF30;F5H066;F5H0S9;Q9UP95-2;Q9UP95	.;.;.;.;.;S12A4_HUMAN	W	789;756;781;787	ENSP00000395983:R789W;ENSP00000438334:R756W;ENSP00000445962:R781W;ENSP00000318557:R787W	ENSP00000318557:R787W	R	-	1	2	SLC12A4	66537920	1.000000	0.71417	1.000000	0.80357	0.983000	0.72400	3.502000	0.53332	0.220000	0.20860	-0.262000	0.10625	CGG		TCGA-FB-AAPQ-01A-11D-A40W-08	SLC12A4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000268864.4	0	0	0	5	293	0	100	0	4.855636e-02	0	17	0	100	2								1	0.933504	5	286	0	100	2								-2.416984	0	1	121396	1	32	1	1	2	3	2.077825	0	0.470000	1.900000	0.474936	0.070000	2.000000e-02	1.000000	0.080000	0.111909	0.070000	0	0.040000	0.120000
ADAMTS18	170692	broad.mit.edu	37	16	77317858	77317858	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr16:77317858T>C	ENST00000282849.5	-	23	4079	c.3661A>G	c.(3661-3663)Atc>Gtc	p.I1221V	RP11-538I12.3_ENST00000561672.1_RNA	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18			118					CAAGATCAGATCTTCCTTGTG	0.512000																								0							SO:0001583	missense			ENST00000282849.5	0	1	hg19	CCDS10926.1	.	.	.	.	.	.	.	.	.	.	T	16.71	3.199573	0.58126	.	.	ENSG00000140873	ENST00000282849	T	0.59083	0.29	5.82	5.82	0.92795	PLAC (1);	0.342462	0.35320	N	0.003290	T	0.40595	0.1123	N	0.08118	0	0.34873	D	0.743774	B	0.16396	0.017	B	0.15870	0.014	T	0.51545	-0.8692	10	0.87932	D	0	.	15.3675	0.74535	0.0:0.0:0.0:1.0	.	1221	Q8TE60	ATS18_HUMAN	V	1221	ENSP00000282849:I1221V	ENSP00000282849:I1221V	I	-	1	0	ADAMTS18	75875359	1.000000	0.71417	1.000000	0.80357	0.748000	0.42578	5.218000	0.65257	2.225000	0.72522	0.533000	0.62120	ATC		TCGA-FB-AAPQ-01A-11D-A40W-08	ADAMTS18-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000269037.1	0	0	0	15	267	0	107		0	0	0	0	107	2								1	0.999870	15	263	0	107	2								-17.687750	1	1	0	0		1	1	2	3	2.076040	0	0.470000	1.900000	0.472479	0.230000	1.300000e-01	0.380000	0.220000	0.247358	0.230000	0	0.170000	0.300000
ZCCHC14	23174	broad.mit.edu	37	16	87466772	87466772	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr16:87466772G>A	ENST00000268616.4	-	3	536	c.319C>T	c.(319-321)Cac>Tac	p.H107Y		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14			36					TTTTTTGTGTGTGATAATCCC	0.343000																								0							SO:0001583	missense			ENST00000268616.4	0	1	hg19	CCDS10961.1	.	.	.	.	.	.	.	.	.	.	G	19.82	3.898473	0.72639	.	.	ENSG00000140948	ENST00000268616	T	0.67865	-0.29	5.09	5.09	0.68999	Phox homologous domain (1);	0.000000	0.85682	D	0.000000	T	0.78572	0.4304	L	0.60455	1.87	0.35943	D	0.833362	D	0.63880	0.993	D	0.70227	0.968	D	0.84115	0.0403	10	0.72032	D	0.01	-25.1339	15.7875	0.78319	0.0:0.0:1.0:0.0	.	107	Q8WYQ9	ZCH14_HUMAN	Y	107	ENSP00000268616:H107Y	ENSP00000268616:H107Y	H	-	1	0	ZCCHC14	86024273	1.000000	0.71417	1.000000	0.80357	0.994000	0.84299	3.594000	0.54008	2.529000	0.85273	0.563000	0.77884	CAC		TCGA-FB-AAPQ-01A-11D-A40W-08	ZCCHC14-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000269107.1	0	0	0	4	144	0	75	0	1.756678e-02	0	6	0	75	2								1	0.884889	4	140	0	74	2								-6.257671	1	1	0	0		1	1	2	3	2.076040	0	0.470000	1.900000	0.472479	0.120000	4.000000e-02	0.310000	0.120000	0.149848	0.120000	0	0.070000	0.200000
SRCIN1	80725	broad.mit.edu	37	17	36709027	36709027	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr17:36709027C>T	ENST00000264659.7	-	12	2490	c.2266G>A	c.(2266-2268)Ggc>Agc	p.G756S	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Missense_Mutation_p.G790S	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1			19					AGCTCAGGGCCGGGCACCAGC	0.612000																								0							SO:0001583	missense			ENST00000264659.7	0	1	hg19	CCDS45660.1	.	.	.	.	.	.	.	.	.	.	C	15.76	2.929532	0.52759	0.0	2.36E-4	ENSG00000017373	ENST00000264659;ENST00000542707;ENST00000398579	T	0.50548	0.74	4.85	4.85	0.62838	.	0.112392	0.64402	D	0.000014	T	0.39462	0.1079	L	0.36672	1.1	0.46416	D	0.999031	P;P;P;P	0.45428	0.858;0.625;0.625;0.625	B;B;B;B	0.38020	0.263;0.128;0.128;0.128	T	0.43861	-0.9365	10	0.56958	D	0.05	-30.4219	17.2494	0.87038	0.0:1.0:0.0:0.0	.	62;628;628;756	Q9C0H9-4;Q9C0H9-2;Q9C0H9;Q9C0H9-5	.;.;SRCN1_HUMAN;.	S	756;537;610	ENSP00000264659:G756S	ENSP00000264659:G756S	G	-	1	0	SRCIN1	33962553	0.651000	0.27340	0.957000	0.39632	0.297000	0.27493	5.445000	0.66594	2.678000	0.91216	0.555000	0.69702	GGC		TCGA-FB-AAPQ-01A-11D-A40W-08	SRCIN1-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000441878.4	0	0	0	87	270	0	137	0	2.529929e-01	0	4	0	137	2								1	1.000000	83	263	0	136	2								-3.318794	1	1	120998	45	47	1	1	2	3	2.096221	0	0.470000	1.900000	0.477369	0.990000	8.600000e-01	1.000000	1.000000	0.983537	0.990000	1	0.950000	1.000000
COLEC12	81035	broad.mit.edu	37	18	335116	335116	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr18:335116G>A	ENST00000400256.3	-	6	1649	c.1442C>T	c.(1441-1443)gCg>gTg	p.A481V		NM_130386.2	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12			46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)			TCTCTCACCCGCAGGGCCAGG	0.652000																								0							SO:0001583	missense			ENST00000400256.3	0	1	hg19	CCDS32782.1	.	.	.	.	.	.	.	.	.	.	G	3.103	-0.184432	0.06340	.	.	ENSG00000158270	ENST00000400256	T	0.17213	2.29	5.67	3.86	0.44501	.	0.260619	0.44483	D	0.000456	T	0.09774	0.0240	N	0.20328	0.56	0.09310	N	1	B	0.10296	0.003	B	0.08055	0.003	T	0.17868	-1.0355	10	0.26408	T	0.33	-17.5347	8.4346	0.32780	0.1196:0.0:0.7477:0.1327	.	481	Q5KU26	COL12_HUMAN	V	481	ENSP00000383115:A481V	ENSP00000383115:A481V	A	-	2	0	COLEC12	325116	0.000000	0.05858	0.137000	0.22149	0.025000	0.11179	0.946000	0.29069	2.659000	0.90383	0.655000	0.94253	GCG		TCGA-FB-AAPQ-01A-11D-A40W-08	COLEC12-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000440746.1	0	0	0	9	276	0	79	0	7.550262e-03	0	4	0	79	2								1	0.993539	9	267	0	79	2								-3.025834	1	1	121268	2	33	1	1	2	3	2.066966	0	0.470000	1.900000	0.472479	0.130000	6.000000e-02	0.270000	0.140000	0.156724	0.130000	0	0.090000	0.200000
SMAD4	4089	broad.mit.edu	37	18	48591919	48591919	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr18:48591919G>A	ENST00000342988.3	+	9	1620	c.1082G>A	c.(1081-1083)cGc>cAc	p.R361H	SMAD4_ENST00000588745.1_Missense_Mutation_p.R265H|SMAD4_ENST00000398417.2_Missense_Mutation_p.R361H	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	p.0?(36)|p.R361H(12)|p.?(2)		454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)			GGAGGAGATCGCTTTTGTTTG	0.413000																								50	Whole gene deletion(36)|Substitution - Missense(12)|Unknown(2)	GRCh37	CM004254	SMAD4	M		SO:0001583	missense			ENST00000342988.3	0	1	hg19	CCDS11950.1	.	.	.	.	.	.	.	.	.	.	G	35	5.477304	0.96291	.	.	ENSG00000141646	ENST00000342988;ENST00000544926;ENST00000398417	D;D	0.98120	-4.73;-4.73	5.86	5.86	0.93980	SMAD domain-like (1);SMAD/FHA domain (1);SMAD domain, Dwarfin-type (3);	0.000000	0.85682	D	0.000000	D	0.98852	0.9612	M	0.86028	2.79	0.80722	D	1	D	0.89917	1.0	D	0.97110	1.0	D	0.99741	1.1015	10	0.87932	D	0	.	18.9646	0.92691	0.0:0.0:1.0:0.0	.	361	Q13485	SMAD4_HUMAN	H	361	ENSP00000341551:R361H;ENSP00000381452:R361H	ENSP00000341551:R361H	R	+	2	0	SMAD4	46845917	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.828000	0.86729	2.771000	0.95319	0.563000	0.77884	CGC		TCGA-FB-AAPQ-01A-11D-A40W-08	SMAD4-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255993.3	0	0	0	61	144	0	107	1	9.975555e-01	18	7	0	107	2								1	1.000000	60	143	0	105	2								-20.000000	1	1	0	0		1	0	1	1	1.599815	1	0.470000	1.900000	0.309311	0.910000	7.500000e-01	1.000000	1.000000	0.912440	0.910000	1	0.830000	0.980000
HAUS8	93323	broad.mit.edu	37	19	17173553	17173553	+	Missense_Mutation	SNP	T	T	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr19:17173553T>A	ENST00000253669.5	-	4	374	c.184A>T	c.(184-186)Atg>Ttg	p.M62L	HAUS8_ENST00000593360.1_Start_Codon_SNP_p.M1L|HAUS8_ENST00000448593.2_Missense_Mutation_p.M62L			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8			12					CCTTCAGACATCTTCCCTCGG	0.537000																								0							SO:0001583	missense			ENST00000253669.5	0	1	hg19	CCDS32948.1	.	.	.	.	.	.	.	.	.	.	T	2.950	-0.216853	0.06101	.	.	ENSG00000131351	ENST00000253669;ENST00000448593	T;T	0.42513	0.98;0.97	2.45	-2.04	0.07343	.	0.866434	0.09993	N	0.729472	T	0.31638	0.0803	L	0.51422	1.61	0.09310	N	1	B;B;B	0.09022	0.002;0.001;0.001	B;B;B	0.06405	0.002;0.001;0.001	T	0.25745	-1.0123	10	0.27785	T	0.31	-2.9844	7.0491	0.25063	0.0:0.5648:0.0:0.4352	.	1;62;62	Q9BT25-2;C9JBZ4;Q9BT25	.;.;HAUS8_HUMAN	L	62	ENSP00000253669:M62L;ENSP00000395298:M62L	ENSP00000253669:M62L	M	-	1	0	HAUS8	17034553	0.001000	0.12720	0.000000	0.03702	0.006000	0.05464	-0.360000	0.07622	-0.611000	0.05709	-0.379000	0.06801	ATG		TCGA-FB-AAPQ-01A-11D-A40W-08	HAUS8-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000463015.1	0	0	0	19	385	0	173	0	2.278999e-02	1	4	0	173	2								1	0.999990	19	378	0	169	2								-19.677420	1	1	0	0		1	1	2	3	2.130903	0	0.470000	1.900000	0.480977	0.210000	1.200000e-01	1.000000	0.210000	0.270681	0.210000	0	0.160000	0.280000
LILRA2	11027	broad.mit.edu	37	19	55086476	55086476	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr19:55086476G>T	ENST00000251377.3	+	5	764	c.631G>T	c.(631-633)Gat>Tat	p.D211Y	LILRA2_ENST00000391737.1_Missense_Mutation_p.D199Y|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.D211Y|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.D211Y|LILRB1_ENST00000448689.1_Intron			Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2			50					TCTACCCAGTGATCTCCTGGA	0.587000																								0							SO:0001583	missense			ENST00000251377.3	0	1	hg19	CCDS46179.1	.	.	.	.	.	.	.	.	.	.	G	12.55	1.971086	0.34754	.	.	ENSG00000239998	ENST00000439534;ENST00000251377;ENST00000391738;ENST00000251376;ENST00000391737	T;T;T;T;T	0.01051	5.4;5.4;5.4;5.4;5.4	2.8	1.75	0.24633	Immunoglobulin-like fold (1);	1.008970	0.07965	N	0.983077	T	0.08313	0.0207	M	0.93808	3.46	0.09310	N	0.999993	P;D;P;D	0.89917	0.748;0.993;0.808;1.0	B;P;B;D	0.69824	0.246;0.906;0.281;0.966	T	0.18967	-1.0320	9	.	.	.	.	5.0171	0.14343	0.1716:0.0:0.8284:0.0	.	211;199;211;211	E9PDF4;A8MZH0;Q8N149;Q8N149-2	.;.;LIRA2_HUMAN;.	Y	211;211;211;211;199	ENSP00000388131:D211Y;ENSP00000251377:D211Y;ENSP00000375618:D211Y;ENSP00000251376:D211Y;ENSP00000375617:D199Y	.	D	+	1	0	LILRA2	59778288	0.001000	0.12720	0.059000	0.19551	0.037000	0.13140	0.087000	0.14958	1.570000	0.49709	0.400000	0.26472	GAT		TCGA-FB-AAPQ-01A-11D-A40W-08	LILRA2-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000140813.2	0	0	0	138	275	0	221		0	0	0	0	221	2								1	1.000000	135	271	0	219	2								-20.000000	1	1	121412	1	36	1	0	1	1	1.647110	1	0.470000	1.900000	0.323807	0.990000	9.200000e-01	1.000000	1.000000	0.993698	0.990000	1	0.980000	1.000000
HRNR	388697	broad.mit.edu	37	1	152191773	152191773	+	Missense_Mutation	SNP	G	G	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:152191773G>C	ENST00000368801.2	-	3	2407	c.2332C>G	c.(2332-2334)Cgt>Ggt	p.R778G	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin			192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)		TGTCGGACACGGCTAGGAGAG	0.592000																								0							SO:0001583	missense			ENST00000368801.2	0	1	hg19	CCDS30859.1	.	.	.	.	.	.	.	.	.	.	-	5.505	0.278141	0.10403	.	.	ENSG00000197915	ENST00000368801	T	0.03801	3.8	3.06	0.0247	0.14143	.	.	.	.	.	T	0.00754	0.0025	N	0.19112	0.55	0.09310	N	1	B	0.27013	0.166	B	0.17722	0.019	T	0.47182	-0.9137	9	0.14252	T	0.57	.	5.1534	0.15021	0.627:0.0:0.373:0.0	.	778	Q86YZ3	HORN_HUMAN	G	778	ENSP00000357791:R778G	ENSP00000357791:R778G	R	-	1	0	HRNR	150458397	0.000000	0.05858	0.000000	0.03702	0.004000	0.04260	-1.096000	0.03353	-0.095000	0.12351	0.508000	0.49915	CGT		TCGA-FB-AAPQ-01A-11D-A40W-08	HRNR-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000034016.1	0	0	0	7	437	0	157		0	0	0	0	157	2								1	0.978272	7	422	0	154	2								-3.300063	1	1	121412	5	43	1	1	2	3	2.507023	1	0.470000	1.900000	0.570032	0.080000	3.000000e-02	0.170000	0.090000	0.093993	0.080000	0	0.050000	0.130000
FCRL1	115350	broad.mit.edu	37	1	157769869	157769869	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:157769869C>T	ENST00000368176.3	-	7	1077	c.1010G>A	c.(1009-1011)cGt>cAt	p.R337H	FCRL1_ENST00000491942.1_Missense_Mutation_p.R337H|FCRL1_ENST00000358292.3_Missense_Mutation_p.R298H|FCRL1_ENST00000489998.1_5'UTR	NM_001159398.1|NM_052938.4	NP_001152870.1|NP_443170.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1			42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)		CCTGGCTGAACGTCTTCCTGA	0.408000													GBM(54;482 1003 11223 30131 35730)											0							SO:0001583	missense			ENST00000368176.3	0	1	hg19	CCDS1170.1	.	.	.	.	.	.	.	.	.	.	C	10.74	1.436657	0.25900	.	.	ENSG00000163534	ENST00000358292;ENST00000368176;ENST00000491942	T;T;T	0.46451	0.87;1.06;1.09	5.03	-0.412	0.12367	.	1.215290	0.05705	N	0.594801	T	0.11623	0.0283	L	0.45581	1.43	0.09310	N	1	B;B;B	0.33739	0.105;0.422;0.064	B;B;B	0.25506	0.027;0.061;0.012	T	0.22068	-1.0227	10	0.45353	T	0.12	.	0.9423	0.01358	0.162:0.4013:0.1578:0.279	.	298;337;337	Q96LA6-3;Q96LA6-2;Q96LA6	.;.;FCRL1_HUMAN	H	298;337;337	ENSP00000351039:R298H;ENSP00000357158:R337H;ENSP00000418130:R337H	ENSP00000351039:R298H	R	-	2	0	FCRL1	156036493	0.001000	0.12720	0.029000	0.17559	0.036000	0.12997	-0.669000	0.05262	-0.134000	0.11516	-0.136000	0.14681	CGT		TCGA-FB-AAPQ-01A-11D-A40W-08	FCRL1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000051401.1	0	0	0	8	397	0	90		0	0	0	0	90	2								1	0.989422	8	396	0	88	2								-7.504347	1	1	0	0		1	1	4	5	3.454336	1	0.470000	1.900000	0.687859	0.140000	6.000000e-02	0.280000	0.150000	0.159669	0.140000	0	0.090000	0.210000
SPTA1	6708	broad.mit.edu	37	1	158653248	158653248	+	Silent	SNP	C	C	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:158653248C>A	ENST00000368147.4	-	3	483	c.303G>T	c.(301-303)gtG>gtT	p.V101V		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1			307	all_hematologic(112;0.0378)				ATTTTGTTTGCACCTCTGCTT	0.398000																								0							SO:0001819	synonymous_variant			ENST00000368147.4	0	1	hg19	CCDS41423.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	SPTA1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000051851.3	0	0	0	6	683	1	170		0	0	0	1	170	2								0	0.036413	6	678	1	169	15								-2.914627	1	1	0	0		1	1	4	5	3.454336	1	0.470000	1.900000	0.687859	0.060000	0	0.140000	0.050000	0.070296	0.060000	0	0.030000	0.110000
DEDD	9191	broad.mit.edu	37	1	161092295	161092295	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:161092295C>T	ENST00000368006.3	-	6	813	c.599G>A	c.(598-600)cGg>cAg	p.R200Q	NIT1_ENST00000368008.1_Intron|DEDD_ENST00000545495.1_Missense_Mutation_p.R200Q|DEDD_ENST00000368005.1_Missense_Mutation_p.R230Q|DEDD_ENST00000458050.2_Missense_Mutation_p.R200Q|DEDD_ENST00000392188.1_Missense_Mutation_p.R230Q|DEDD_ENST00000489249.1_5'UTR|DEDD_ENST00000490843.2_Missense_Mutation_p.R200Q	NM_032998.2	NP_127491.1	O75618	DEDD_HUMAN	death effector domain containing	p.R200L(1)		10	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)		GTATTCAGCCCGAACCCGCAG	0.493000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000368006.3	0	1	hg19	CCDS1219.1	.	.	.	.	.	.	.	.	.	.	C	25.7	4.662293	0.88251	.	.	ENSG00000158796	ENST00000368006;ENST00000392188;ENST00000545495;ENST00000458050;ENST00000541906;ENST00000368005;ENST00000535389	.	.	.	5.03	5.03	0.67393	.	0.000000	0.85682	D	0.000000	T	0.72630	0.3484	M	0.68952	2.095	0.80722	D	1	D;D;D	0.89917	0.996;1.0;1.0	P;D;D	0.80764	0.694;0.994;0.982	T	0.74386	-0.3682	9	0.59425	D	0.04	.	15.9207	0.79570	0.0:1.0:0.0:0.0	.	157;230;200	B4DKM1;B1AQP5;O75618	.;.;DEDD_HUMAN	Q	200;230;200;200;200;230;157	.	ENSP00000356984:R230Q	R	-	2	0	DEDD	159358919	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	7.629000	0.83207	2.620000	0.88729	0.655000	0.94253	CGG		TCGA-FB-AAPQ-01A-11D-A40W-08	DEDD-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000080582.1	0	0	0	56	514	0	97	1	9.999841e-01	27	120	0	97	2								1	1.000000	55	507	0	94	2								-2.578431	1	1	121412	1	28	1	1	4	5	3.454336	1	0.470000	1.900000	0.687859	0.710000	5.400000e-01	0.910000	0.700000	0.719348	0.710000	0	0.620000	0.810000
FCER1G	2207	broad.mit.edu	37	1	161187859	161187859	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			C	T	C	C		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:161187859C>T	ENST00000289902.1	+	2	158	c.133C>T	c.(133-135)Cga>Tga	p.R45*	FCER1G_ENST00000490414.1_Intron|FCER1G_ENST00000367992.3_Nonsense_Mutation_p.R45*|AL590714.1_ENST00000594609.1_5'Flank	NM_004106.1	NP_004097.1	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide			6	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)	Benzylpenicilloyl Polylysine(DB00895)	CCTCTACTGTCGACTGAAGGT	0.562000																								0							SO:0001587	stop_gained			ENST00000289902.1	0	1	hg19	CCDS1225.1	.	.	.	.	.	.	.	.	.	.	C	27.1	4.797467	0.90538	.	.	ENSG00000158869	ENST00000367992;ENST00000289902	.	.	.	5.67	4.73	0.59995	.	0.000000	0.53938	D	0.000051	.	.	.	.	.	.	0.80722	A	1.000000	.	.	.	.	.	.	.	.	.	.	0.02654	T	1	.	11.7665	0.51933	0.1759:0.8241:0.0:0.0	.	.	.	.	X	45	.	ENSP00000289902:R45X	R	+	1	2	FCER1G	159454483	0.983000	0.35010	1.000000	0.80357	0.992000	0.81027	1.508000	0.35769	1.348000	0.45733	0.561000	0.74099	CGA		TCGA-FB-AAPQ-01A-11D-A40W-08	FCER1G-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000083012.1	0	0	0	117	803	0	173	0	9.998355e-01	0	86	0	173	2								1	1.000000	115	786	0	170	2								-20.000000	1	1	121412	2	38	1	1	4	5	3.454336	1	0.470000	1.900000	0.687859	0.910000	7.600000e-01	1.000000	1.000000	0.915971	0.910000	1	0.830000	1.000000
CFHR5	81494	broad.mit.edu	37	1	196952162	196952162	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:196952162G>A	ENST00000256785.4	+	2	315	c.206G>A	c.(205-207)cGc>cAc	p.R69H	CFHR5_ENST00000367414.5_Missense_Mutation_p.R93H			Q9BXR6	FHR5_HUMAN	complement factor H-related 5	p.R69H(1)		49					TTTTGGACTCGCATAACATGC	0.393000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000256785.4	0	1	hg19	CCDS1387.1	.	.	.	.	.	.	.	.	.	.	.	11.96	1.794607	0.31777	2.27E-4	0.0	ENSG00000134389	ENST00000367414;ENST00000256785	T;T	0.64803	-0.12;-0.12	2.45	-4.13	0.03904	Complement control module (2);Sushi/SCR/CCP (2);	.	.	.	.	T	0.45296	0.1335	L	0.46157	1.445	0.09310	N	1	B	0.25521	0.128	B	0.20955	0.032	T	0.24728	-1.0152	9	0.31617	T	0.26	.	4.0223	0.09672	0.3876:0.3452:0.2672:0.0	.	69	Q9BXR6	FHR5_HUMAN	H	93;69	ENSP00000356384:R93H;ENSP00000256785:R69H	ENSP00000256785:R69H	R	+	2	0	CFHR5	195218785	0.000000	0.05858	0.002000	0.10522	0.603000	0.37013	-2.581000	0.00906	-1.048000	0.03238	0.305000	0.20034	CGC		TCGA-FB-AAPQ-01A-11D-A40W-08	CFHR5-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000088814.2	0	0	0	5	404	0	200		0	0	0	0	200	2								1	0.937098	5	402	0	197	2								-2.234064	0	1	121410	6	41	1	1	2	3	2.062215	0	0.470000	1.900000	0.471243	0.050000	1.000000e-02	0.120000	0.060000	0.062064	0.050000	0	0.030000	0.090000
PROX1	5629	broad.mit.edu	37	1	214171246	214171246	+	Silent	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:214171246C>T	ENST00000366958.4	+	2	1976	c.1368C>T	c.(1366-1368)gcC>gcT	p.A456A	PROX1_ENST00000261454.4_Silent_p.A456A|PROX1_ENST00000435016.1_Silent_p.A456A|PROX1_ENST00000498508.2_Silent_p.A456A	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1			47					CCGGCCCTGCCGCTGGCGGCC	0.642000																								0							SO:0001819	synonymous_variant			ENST00000366958.4	0	1	hg19	CCDS31021.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	PROX1-001	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000089727.6	0	0	0	5	465	0	128	0	2.686419e-03	0	6	0	128	2								1	0.926781	5	437	0	126	2								-2.768843	1	1	0	0		1	1	2	3	2.062215	0	0.470000	1.900000	0.471243	0.040000	0	0.110000	0.040000	0.053996	0.040000	0	0.020000	0.080000
CHML	1122	broad.mit.edu	37	1	241798099	241798099	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr1:241798099C>T	ENST00000366553.1	-	1	1133	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000469376.1_Intron|OPN3_ENST00000366554.2_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)			26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)		TTTAAGTATTCTGAAAATGAA	0.343000																								0							SO:0001583	missense			ENST00000366553.1	0	1	hg19	CCDS31073.1	.	.	.	.	.	.	.	.	.	.	C	17.34	3.363993	0.61513	.	.	ENSG00000203668	ENST00000366553	T	0.61510	0.1	4.96	4.96	0.65561	.	0.286583	0.37012	N	0.002299	T	0.63873	0.2548	.	.	.	0.48288	D	0.999624	P	0.35923	0.528	P	0.45099	0.469	T	0.66862	-0.5816	9	0.66056	D	0.02	-7.2311	16.126	0.81395	0.0:1.0:0.0:0.0	.	324	P26374	RAE2_HUMAN	K	324	ENSP00000355511:E324K	ENSP00000355511:E324K	E	-	1	0	CHML	239864722	1.000000	0.71417	1.000000	0.80357	0.924000	0.55760	3.515000	0.53429	2.752000	0.94435	0.655000	0.94253	GAA		TCGA-FB-AAPQ-01A-11D-A40W-08	CHML-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000095712.1	0	0	0	15	382	0	163	1	4.935423e-03	2	1	0	163	2								1	0.999865	15	378	0	162	2								-3.495506	1	1	0	0		1	1	2	3	2.062215	0	0.470000	1.900000	0.471243	0.160000	9.000000e-02	0.260000	0.160000	0.170557	0.160000	0	0.120000	0.210000
BMP7	655	broad.mit.edu	37	20	55758862	55758862	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr20:55758862G>A	ENST00000395863.3	-	4	1379	c.874C>T	c.(874-876)Cgg>Tgg	p.R292W	BMP7_ENST00000395864.3_Intron|BMP7_ENST00000450594.2_Missense_Mutation_p.R292W|BMP7_ENST00000460817.1_5'UTR	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7			20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)		CCCGTGGACCGGATGCTGCGG	0.637000																								0							SO:0001583	missense			ENST00000395863.3	0	1	hg19	CCDS13455.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	28.8|28.8	4.954563|4.954563	0.92726|0.92726	.|.	.|.	ENSG00000101144|ENSG00000101144	ENST00000433911|ENST00000395863;ENST00000450594	.|T;D	.|0.83075	.|-1.19;-1.68	5.48|5.48	4.52|4.52	0.55395|0.55395	.|.	.|0.049998	.|0.85682	.|D	.|0.000000	D|D	0.89083|0.89083	0.6614|0.6614	L|L	0.55990|0.55990	1.75|1.75	0.80722|0.80722	D|D	1|1	.|D;D	.|0.89917	.|1.0;1.0	.|D;D	.|0.97110	.|0.985;1.0	D|D	0.90219|0.90219	0.4270|0.4270	5|10	.|0.87932	.|D	.|0	.|.	16.2622|16.2622	0.82552|0.82552	0.0:0.1329:0.8671:0.0|0.0:0.1329:0.8671:0.0	.|.	.|292;292	.|P18075;B1AL00	.|BMP7_HUMAN;.	L|W	213|292	.|ENSP00000379204:R292W;ENSP00000398687:R292W	.|ENSP00000379204:R292W	P|R	-|-	2|1	0|2	BMP7|BMP7	55192269|55192269	1.000000|1.000000	0.71417|0.71417	0.770000|0.770000	0.31555|0.31555	0.984000|0.984000	0.73092|0.73092	9.580000|9.580000	0.98207|0.98207	1.271000|1.271000	0.44313|0.44313	0.643000|0.643000	0.83706|0.83706	CCG|CGG		TCGA-FB-AAPQ-01A-11D-A40W-08	BMP7-001	KNOWN	basic|appris_principal|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000079831.2	0	0	0	109	286	1	120	0	0	0	1	1	120	2								1	1.000000	107	279	1	117	13								-6.483964	1	1	0	0		1	1	2	3	2.138800	0	0.470000	1.900000	0.482169	0.990000	9.900000e-01	1.000000	1.000000	0.999532	0.990000	1	0.990000	1.000000
INPP5J	27124	broad.mit.edu	37	22	31523352	31523352	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr22:31523352G>A	ENST00000331075.5	+	6	1670	c.1621G>A	c.(1621-1623)Ggt>Agt	p.G541S	INPP5J_ENST00000405300.1_Missense_Mutation_p.G174S|INPP5J_ENST00000400294.2_Missense_Mutation_p.G174S|INPP5J_ENST00000404453.1_5'Flank|INPP5J_ENST00000412277.2_Missense_Mutation_p.G474S|INPP5J_ENST00000401755.1_5'Flank|INPP5J_ENST00000404390.3_Missense_Mutation_p.G173S|INPP5J_ENST00000402238.1_5'Flank	NM_001284285.1	NP_001271214.1	Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J			12					GGGTAACAAGGGTGGCGTGAG	0.637000																								0							SO:0001583	missense			ENST00000331075.5	0	1	hg19		.	.	.	.	.	.	.	.	.	.	G	35	5.565391	0.96527	.	.	ENSG00000185133	ENST00000331075;ENST00000412277;ENST00000400294;ENST00000405300;ENST00000404390	D;D;D;D;D	0.96913	-4.17;-4.17;-4.17;-4.17;-4.17	4.37	4.37	0.52481	Endonuclease/exonuclease/phosphatase (2);Inositol polyphosphate-related phosphatase (1);	0.000000	0.85682	D	0.000000	D	0.98713	0.9568	H	0.95187	3.635	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.97110	1.0;1.0	D	0.99744	1.1016	10	0.87932	D	0	.	17.8398	0.88712	0.0:0.0:1.0:0.0	.	541;173	Q15735;Q15735-3	PI5PA_HUMAN;.	S	541;474;174;174;173	ENSP00000333262:G541S;ENSP00000392924:G474S;ENSP00000383150:G174S;ENSP00000384596:G174S;ENSP00000384534:G173S	ENSP00000333262:G541S	G	+	1	0	INPP5J	29853352	1.000000	0.71417	0.997000	0.53966	0.977000	0.68977	9.453000	0.97619	2.363000	0.80096	0.655000	0.94253	GGT		TCGA-FB-AAPQ-01A-11D-A40W-08	INPP5J-002	KNOWN	basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000321784.1	0	0	0	19	72	0	19	1	4.804393e-02	2	0	0	19	2								1	0.999995	17	72	0	19	2								-20.000000	1	1	0	0		1	1	2	3	2.100040	0	0.470000	1.900000	0.477369	0.910000	5.800000e-01	1.000000	1.000000	0.883317	0.910000	1	0.730000	1.000000
REV1	51455	broad.mit.edu	37	2	100027216	100027216	+	Silent	SNP	A	A	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:100027216A>C	ENST00000258428.3	-	14	2514	c.2286T>G	c.(2284-2286)ccT>ccG	p.P762P	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Silent_p.P761P	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)			39					CAGGAGCCCCAGGCTTTCGTA	0.398000								Direct reversal of damage																0							SO:0001819	synonymous_variant			ENST00000258428.3	0	1	hg19	CCDS2045.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	REV1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000253123.2	0	0	0	103	404	0	194	1	9.198008e-01	9	10	0	194	2								1	1.000000	102	400	0	191	2								-20.000000	1	1	0	0		1	1	2	3	2.061050	0	0.470000	1.900000	0.471243	0.860000	7.100000e-01	1.000000	1.000000	0.867952	0.860000	1	0.780000	0.950000
IL18RAP	8807	broad.mit.edu	37	2	103068312	103068312	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:103068312A>G	ENST00000264260.2	+	12	2060	c.1471A>G	c.(1471-1473)Atc>Gtc	p.I491V	IL18RAP_ENST00000409369.1_Missense_Mutation_p.I349V	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein			37					TGGACCCAGTATCTTTGAACT	0.383000																								0							SO:0001583	missense			ENST00000264260.2	0	1	hg19	CCDS2061.1	.	.	.	.	.	.	.	.	.	.	A	0.008	-1.864991	0.00547	.	.	ENSG00000115607	ENST00000264260;ENST00000409369	T;T	0.07800	3.16;3.16	6.02	-7.56	0.01322	Toll/interleukin-1 receptor homology (TIR) domain (4);	0.966608	0.08561	N	0.927536	T	0.03871	0.0109	N	0.13352	0.335	0.09310	N	0.999999	B	0.09022	0.002	B	0.10450	0.005	T	0.46978	-0.9152	10	0.13470	T	0.59	.	10.3177	0.43747	0.5517:0.241:0.2073:0.0	.	491	O95256	I18RA_HUMAN	V	491;349	ENSP00000264260:I491V;ENSP00000387201:I349V	ENSP00000264260:I491V	I	+	1	0	IL18RAP	102434744	0.001000	0.12720	0.000000	0.03702	0.029000	0.11900	-0.198000	0.09505	-1.839000	0.01186	-0.917000	0.02746	ATC		TCGA-FB-AAPQ-01A-11D-A40W-08	IL18RAP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000253291.2	0	0	0	19	407	0	198		0	0	0	0	198	2								1	0.999991	19	404	0	198	2								-19.530980	1	1	0	0		1	1	2	3	2.061050	0	0.470000	1.900000	0.471243	0.190000	1.100000e-01	0.290000	0.190000	0.198789	0.190000	0	0.150000	0.240000
SNTG2	54221	broad.mit.edu	37	2	1243542	1243542	+	Silent	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:1243542C>T	ENST00000308624.5	+	11	1011	c.882C>T	c.(880-882)tcC>tcT	p.S294S	SNTG2_ENST00000407292.1_Silent_p.S167S	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2			52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)			GCTCTCCTTCCGACCAGGTAG	0.473000																								0							SO:0001819	synonymous_variant			ENST00000308624.5	0	1	hg19	CCDS46220.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	SNTG2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000322454.1	0	0	0	27	44	0	31	0	0	0	1	0	31	2								1	1.000000	26	43	0	31	2								-6.637137	1	1	121014	5	38	1	0	1	1	1.576691	1	0.470000	1.900000	0.307190	0.930000	7.400000e-01	1.000000	0.990000	0.923341	0.930000	1	0.850000	0.990000
ZNF804A	91752	broad.mit.edu	37	2	185802417	185802417	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:185802417C>T	ENST00000302277.6	+	4	2888	c.2294C>T	c.(2293-2295)tCa>tTa	p.S765L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A			146					ATGAATGAATCAGAAAGATTC	0.338000																								0							SO:0001583	missense			ENST00000302277.6	0	1	hg19	CCDS2291.1	.	.	.	.	.	.	.	.	.	.	C	16.08	3.022703	0.54683	.	.	ENSG00000170396	ENST00000302277	T	0.05925	3.37	5.85	5.85	0.93711	.	0.288957	0.24764	N	0.035786	T	0.09730	0.0239	L	0.47716	1.5	0.35829	D	0.825133	P	0.35077	0.483	B	0.33392	0.163	T	0.06881	-1.0802	10	0.87932	D	0	-6.925	19.1378	0.93435	0.0:1.0:0.0:0.0	.	765	Q7Z570	Z804A_HUMAN	L	765	ENSP00000303252:S765L	ENSP00000303252:S765L	S	+	2	0	ZNF804A	185510662	0.129000	0.22400	0.694000	0.30210	0.985000	0.73830	2.805000	0.47939	2.755000	0.94549	0.655000	0.94253	TCA		TCGA-FB-AAPQ-01A-11D-A40W-08	ZNF804A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255871.1	0	0	0	67	264	0	134		0	0	0	0	134	2								1	1.000000	67	263	0	134	2								-20.000000	1	0	0	0		1	0	0	0	1.976499	0	0.470000	1.900000	0.449293	0.820000	6.500000e-01	1.000000	0.830000	0.831741	0.820000	0	0.730000	0.920000
EPHA4	2043	broad.mit.edu	37	2	222301271	222301271	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:222301271A>G	ENST00000281821.2	-	13	2235	c.2194T>C	c.(2194-2196)Tct>Cct	p.S732P	EPHA4_ENST00000409938.1_Missense_Mutation_p.S732P|EPHA4_ENST00000392071.4_Missense_Mutation_p.S681P|EPHA4_ENST00000409854.1_Missense_Mutation_p.S732P	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4			49		Renal(207;0.0183)			TTCATCCCAGACCCAATGCCA	0.453000																								0							SO:0001583	missense			ENST00000281821.2	0	1	hg19	CCDS2447.1	.	.	.	.	.	.	.	.	.	.	A	19.69	3.874684	0.72180	.	.	ENSG00000116106	ENST00000281821;ENST00000409854;ENST00000409938;ENST00000392071	D;D;D;D	0.83335	-1.71;-1.71;-1.71;-1.71	5.98	5.98	0.97165	Serine-threonine/tyrosine-protein kinase (1);Protein kinase-like domain (1);Tyrosine-protein kinase, catalytic domain (1);Protein kinase, catalytic domain (1);	0.000000	0.85682	D	0.000000	D	0.92808	0.7713	M	0.91818	3.245	0.80722	D	1	D	0.89917	1.0	D	0.71870	0.975	D	0.94191	0.7441	10	0.87932	D	0	.	16.4684	0.84092	1.0:0.0:0.0:0.0	.	732	P54764	EPHA4_HUMAN	P	732;732;732;681	ENSP00000281821:S732P;ENSP00000386276:S732P;ENSP00000386829:S732P;ENSP00000375923:S681P	ENSP00000281821:S732P	S	-	1	0	EPHA4	222009515	1.000000	0.71417	0.981000	0.43875	0.915000	0.54546	7.306000	0.78905	2.289000	0.77006	0.460000	0.39030	TCT		TCGA-FB-AAPQ-01A-11D-A40W-08	EPHA4-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256836.3	0	0	0	79	429	0	172	1	2.486474e-02	2	0	0	172	2								1	1.000000	77	423	0	168	2								-20.000000	1	1	0	0		1	1	2	3	2.373236	1	0.470000	1.900000	0.552988	0.800000	6.300000e-01	1.000000	0.780000	0.823035	0.800000	0	0.710000	1.000000
NEU4	129807	broad.mit.edu	37	2	242757458	242757458	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:242757458G>A	ENST00000391969.2	+	5	1250	c.539G>A	c.(538-540)cGc>cAc	p.R180H	NEU4_ENST00000405370.1_Missense_Mutation_p.R180H|NEU4_ENST00000407683.1_Missense_Mutation_p.R180H|NEU4_ENST00000325935.6_Missense_Mutation_p.R193H|NEU4_ENST00000404257.1_Missense_Mutation_p.R192H	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4			15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)			TACACCTACCGCGTGGACCGC	0.677000																								0							SO:0001583	missense			ENST00000391969.2	0	1	hg19	CCDS54442.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	5.676|5.676	0.309365|0.309365	0.10733|0.10733	.|.	.|.	ENSG00000204099|ENSG00000204099	ENST00000415936;ENST00000426032|ENST00000407683;ENST00000405370;ENST00000472793;ENST00000423583;ENST00000404257;ENST00000391969;ENST00000325935;ENST00000420288	T;T|D;D;D;D;D;D;D	0.36340|0.84516	1.26;1.27|-1.86;-1.86;-1.86;-1.86;-1.86;-1.86;-1.86	4.47|4.47	-3.37|-3.37	0.04898|0.04898	.|Neuraminidase (2);	.|0.278834	.|0.39020	.|N	.|0.001484	T|T	0.61160|0.61160	0.2325|0.2325	N|N	0.03209|0.03209	-0.39|-0.39	0.24176|0.24176	N|N	0.9956|0.9956	.|B;B;B	.|0.11235	.|0.004;0.004;0.004	.|B;B;B	.|0.11329	.|0.001;0.001;0.006	T|T	0.52909|0.52909	-0.8512|-0.8512	7|10	0.22706|0.11182	T|T	0.39|0.66	-5.5641|-5.5641	11.8952|11.8952	0.52652|0.52652	0.8204:0.0:0.1796:0.0|0.8204:0.0:0.1796:0.0	.|.	.|192;192;180	.|A8K211;Q8WWR8-2;Q8WWR8	.|.;.;NEUR4_HUMAN	T|H	95;107|180;180;190;180;192;180;193;180	ENSP00000397167:A95T;ENSP00000406678:A107T|ENSP00000385402:R180H;ENSP00000384804:R180H;ENSP00000397860:R180H;ENSP00000385149:R192H;ENSP00000375830:R180H;ENSP00000320318:R193H;ENSP00000388707:R180H	ENSP00000397167:A95T|ENSP00000320318:R193H	A|R	+|+	1|2	0|0	NEU4|NEU4	242406131|242406131	0.764000|0.764000	0.28473|0.28473	0.501000|0.501000	0.27601|0.27601	0.978000|0.978000	0.69477|0.69477	0.875000|0.875000	0.28079|0.28079	-0.569000|-0.569000	0.06030|0.06030	0.443000|0.443000	0.29094|0.29094	GCG|CGC		TCGA-FB-AAPQ-01A-11D-A40W-08	NEU4-002	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257270.2	0	0	0	25	100	0	34		0	0	0	0	34	2								1	1.000000	25	96	0	34	2								-20.000000	1	1	0	0		1	1	2	3	2.425160	1	0.470000	1.900000	0.562526	0.990000	7.100000e-01	1.000000	1.000000	0.953724	0.990000	1	0.870000	1.000000
PROKR1	10887	broad.mit.edu	37	2	68882679	68882679	+	Missense_Mutation	SNP	G	G	A	rs139618486		TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr2:68882679G>A	ENST00000303786.3	+	3	1573	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K	PROKR1_ENST00000394342.2_Missense_Mutation_p.E385K			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1			35					GCCTGCCACCGAAGAGGTGGA	0.488000																								0							SO:0001583	missense			ENST00000303786.3	0	1	hg19	CCDS1889.1	.	.	.	.	.	.	.	.	.	.	G	18.96	3.734748	0.69189	0.0	1.16E-4	ENSG00000169618	ENST00000303786;ENST00000394342	T;T	0.72835	-0.69;-0.69	4.48	4.48	0.54585	.	0.000000	0.85682	D	0.000000	T	0.78874	0.4352	L	0.59436	1.845	0.58432	D	0.999999	D	0.89917	1.0	D	0.68765	0.96	T	0.72972	-0.4129	10	0.18276	T	0.48	.	15.4772	0.75493	0.0:0.0:1.0:0.0	.	385	Q8TCW9	PKR1_HUMAN	K	385	ENSP00000303775:E385K;ENSP00000377874:E385K	ENSP00000303775:E385K	E	+	1	0	PROKR1	68736183	1.000000	0.71417	0.963000	0.40424	0.364000	0.29643	8.626000	0.90969	2.779000	0.95612	0.655000	0.94253	GAA		TCGA-FB-AAPQ-01A-11D-A40W-08	PROKR1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000251760.2	0	0	0	55	127	0	68		0	0	0	0	68	2								1	1.000000	54	125	0	68	2								-6.677265	1	1	0	0		1	1	2	3	2.061050	0	0.470000	1.900000	0.471243	0.990000	9.900000e-01	1.000000	1.000000	0.999178	0.990000	1	0.990000	1.000000
CPB1	1360	broad.mit.edu	37	3	148563359	148563359	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr3:148563359G>A	ENST00000491148.1	+	10	1261	c.927G>A	c.(925-927)atG>atA	p.M309I	CPB1_ENST00000282957.4_Missense_Mutation_p.M309I			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)			38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)		ACTCCCAAATGATGATCTACC	0.423000																								0							SO:0001583	missense			ENST00000491148.1	0	1	hg19	CCDS33874.1	.	.	.	.	.	.	.	.	.	.	G	15.34	2.804211	0.50315	.	.	ENSG00000153002	ENST00000491148;ENST00000282957	T;T	0.10382	2.88;2.88	5.69	5.69	0.88448	Peptidase M14, carboxypeptidase A (4);	0.189388	0.56097	D	0.000025	T	0.22859	0.0552	M	0.67700	2.07	0.48696	D	0.999698	P	0.38992	0.653	P	0.47102	0.537	T	0.00180	-1.1949	10	0.87932	D	0	.	14.9509	0.71074	0.0702:0.0:0.9298:0.0	.	309	P15086	CBPB1_HUMAN	I	309	ENSP00000417222:M309I;ENSP00000282957:M309I	ENSP00000282957:M309I	M	+	3	0	CPB1	150046049	1.000000	0.71417	0.994000	0.49952	0.035000	0.12851	3.756000	0.55205	2.677000	0.91161	0.655000	0.94253	ATG		TCGA-FB-AAPQ-01A-11D-A40W-08	CPB1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000355928.1	0	0	0	66	282	0	125	0	6.478914e-01	0	11	0	125	2								1	1.000000	66	276	0	123	2								-20.000000	1	1	0	0		1	0	0	0	2.048269	0	0.470000	1.900000	0.470000	0.800000	6.300000e-01	0.980000	0.800000	0.811151	0.800000	0	0.710000	0.900000
DOCK3	1795	broad.mit.edu	37	3	51418535	51418535	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr3:51418535G>A	ENST00000266037.9	+	53	5661	c.5638G>A	c.(5638-5640)Ggc>Agc	p.G1880S		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3			45					AGGTCTGGACGGCAGCAACTC	0.617000																								0							SO:0001583	missense			ENST00000266037.9	0	1	hg19	CCDS46835.1	.	.	.	.	.	.	.	.	.	.	G	28.0	4.883752	0.91814	.	.	ENSG00000088538	ENST00000266037	T	0.04119	3.7	6.17	6.17	0.99709	.	0.000000	0.85682	D	0.000000	T	0.12008	0.0292	N	0.21583	0.68	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	T	0.40739	-0.9547	10	0.10111	T	0.7	.	20.8794	0.99867	0.0:0.0:1.0:0.0	.	1880	Q8IZD9	DOCK3_HUMAN	S	1880	ENSP00000266037:G1880S	ENSP00000266037:G1880S	G	+	1	0	DOCK3	51393575	1.000000	0.71417	0.994000	0.49952	0.963000	0.63663	9.221000	0.95188	2.941000	0.99782	0.655000	0.94253	GGC		TCGA-FB-AAPQ-01A-11D-A40W-08	DOCK3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000346478.5	0	0	0	124	290	1	183		0	0	0	1	183	2								1	1.000000	120	284	1	178	10								-9.121468	1	1	121374	1	34	1	0	1	1	1.578307	1	0.470000	1.900000	0.307190	0.930000	8.100000e-01	1.000000	0.970000	0.933179	0.930000	1	0.870000	0.980000
KIAA0922	23240	broad.mit.edu	37	4	154557660	154557660	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr4:154557660A>C	ENST00000409663.3	+	35	4814	c.4762A>C	c.(4762-4764)Act>Cct	p.T1588P	KIAA0922_ENST00000440693.1_Missense_Mutation_p.T1505P|KIAA0922_ENST00000409959.3_Missense_Mutation_p.T1589P	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922			63	all_hematologic(180;0.093)	Renal(120;0.118)			GGACATATGGACTACCACAGC	0.443000																								0							SO:0001583	missense			ENST00000409663.3	0	1	hg19	CCDS3783.2	.	.	.	.	.	.	.	.	.	.	A	26.5	4.745420	0.89663	.	.	ENSG00000121210	ENST00000409663;ENST00000440693;ENST00000409959;ENST00000240487	T;T;T;T	0.23147	2.22;1.92;2.22;1.93	5.93	5.93	0.95920	.	0.053443	0.85682	D	0.000000	T	0.38054	0.1026	N	0.19112	0.55	0.58432	D	0.999999	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.91635	0.999;0.998;0.996	T	0.33111	-0.9881	10	0.72032	D	0.01	-21.6398	16.3721	0.83368	1.0:0.0:0.0:0.0	.	1505;1589;1588	A2VDJ0-3;A2VDJ0-5;A2VDJ0	.;.;T131L_HUMAN	P	1588;1505;1589;1366	ENSP00000386574:T1588P;ENSP00000409663:T1505P;ENSP00000386787:T1589P;ENSP00000240487:T1366P	ENSP00000240487:T1366P	T	+	1	0	KIAA0922	154777110	1.000000	0.71417	1.000000	0.80357	0.967000	0.64934	8.620000	0.90943	2.257000	0.74773	0.533000	0.62120	ACT		TCGA-FB-AAPQ-01A-11D-A40W-08	KIAA0922-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000330370.1	0	0	0	18	370	0	150	0	6.989887e-02	0	9	0	150	2								1	0.999983	18	369	0	149	2								-18.961690	1	1	0	0		1	1	2	3	2.051090	0	0.470000	1.900000	0.471243	0.190000	1.100000e-01	0.310000	0.200000	0.207198	0.190000	0	0.150000	0.250000
CCDC69	26112	broad.mit.edu	37	5	150584969	150584969	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr5:150584969C>G	ENST00000355417.2	-	2	290	c.116G>C	c.(115-117)gGg>gCg	p.G39A	CCDC69_ENST00000521308.1_Intron	NM_015621.2	NP_056436.2	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69			9		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		ACCTGTGTCCCCATTGAGGGG	0.517000																								0							SO:0001583	missense			ENST00000355417.2	0	1	hg19	CCDS4312.1	.	.	.	.	.	.	.	.	.	.	C	16.48	3.135710	0.56828	.	.	ENSG00000198624	ENST00000355417	T	0.22134	1.97	4.32	-1.51	0.08664	.	1.518870	0.03672	N	0.244161	T	0.13586	0.0329	L	0.27053	0.805	0.09310	N	1	B	0.21606	0.058	B	0.22601	0.04	T	0.26155	-1.0111	10	0.07990	T	0.79	-0.9078	7.9535	0.30029	0.0:0.3237:0.0:0.6763	.	39	A6NI79	CCD69_HUMAN	A	39	ENSP00000347586:G39A	ENSP00000347586:G39A	G	-	2	0	CCDC69	150565162	0.002000	0.14202	0.007000	0.13788	0.986000	0.74619	-0.301000	0.08232	-0.179000	0.10654	0.555000	0.69702	GGG		TCGA-FB-AAPQ-01A-11D-A40W-08	CCDC69-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252435.1	0	0	0	52	176	0	30	0	2.286236e-01	0	4	0	30	2								1	1.000000	51	172	0	29	2								-3.128305	1	1	0	0		1	1	2	3	2.064620	0	0.470000	1.900000	0.472479	0.970000	7.500000e-01	1.000000	1.000000	0.942781	0.970000	1	0.850000	1.000000
TNXB	7148	broad.mit.edu	37	6	32046935	32046935	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr6:32046935C>T	ENST00000375244.3	-	11	4451	c.4250G>A	c.(4249-4251)cGt>cAt	p.R1417H	TNXB_ENST00000375247.2_Missense_Mutation_p.R1417H|RNA5SP206_ENST00000516703.1_RNA			P22105	TENX_HUMAN	tenascin XB			8					GCCCCCAACACGCACCGCCCG	0.662000																								0							SO:0001583	missense			ENST00000375244.3	0	1	hg19		.	.	.	.	.	.	.	.	.	.	C	13.46	2.244413	0.39697	.	.	ENSG00000168477	ENST00000375244;ENST00000375247	T;T	0.57752	0.38;0.38	5.52	4.64	0.57946	.	0.000000	0.41396	D	0.000889	T	0.34978	0.0916	M	0.67397	2.05	0.29740	N	0.837148	P	0.50617	0.937	P	0.47645	0.553	T	0.22382	-1.0218	10	0.13108	T	0.6	.	9.6088	0.39650	0.1602:0.6853:0.1545:0.0	.	1417	P22105-3	.	H	1417	ENSP00000364393:R1417H;ENSP00000364396:R1417H	ENSP00000364393:R1417H	R	-	2	0	TNXB	32154913	0.459000	0.25768	0.972000	0.41901	0.048000	0.14542	0.667000	0.25112	1.459000	0.47892	0.591000	0.81541	CGT		TCGA-FB-AAPQ-01A-11D-A40W-08	TNXB-001	PUTATIVE	not_organism_supported|basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000268927.2	0	0	0	116	422	0	217	0	0	0	1	0	217	2								1	1.000000	115	417	0	217	2								-20.000000	1	1	120852	1	31	1	0	0	0	2.010714	0	0.470000	1.900000	0.459845	0.890000	7.500000e-01	1.000000	1.000000	0.899085	0.890000	1	0.820000	0.970000
RINT1	60561	broad.mit.edu	37	7	105204334	105204334	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr7:105204334G>A	ENST00000257700.2	+	12	2057	c.1826G>A	c.(1825-1827)cGt>cAt	p.R609H		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1			22					ATGTTGACCCGTCAAGTAGAC	0.388000																								0							SO:0001583	missense			ENST00000257700.2	0	1	hg19	CCDS34726.1	.	.	.	.	.	.	.	.	.	.	G	34	5.392489	0.96009	.	.	ENSG00000135249	ENST00000257700	T	0.30981	1.51	6.17	6.17	0.99709	.	0.000000	0.85682	D	0.000000	T	0.54806	0.1881	L	0.56769	1.78	0.80722	D	1	D	0.76494	0.999	D	0.71414	0.973	T	0.42032	-0.9475	10	0.48119	T	0.1	-16.4485	20.8794	0.99867	0.0:0.0:1.0:0.0	.	609	Q6NUQ1	RINT1_HUMAN	H	609	ENSP00000257700:R609H	ENSP00000257700:R609H	R	+	2	0	RINT1	104991570	1.000000	0.71417	1.000000	0.80357	0.993000	0.82548	7.142000	0.77339	2.941000	0.99782	0.655000	0.94253	CGT		TCGA-FB-AAPQ-01A-11D-A40W-08	RINT1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000348686.1	0	0	0	73	212	1	107	1	9.764036e-01	7	13	1	107	2								1	1.000000	73	210	1	107	11								-5.167447	1	1	121412	1	28	1	1	2	3	2.075402	0	0.470000	1.900000	0.472479	0.990000	8.800000e-01	1.000000	1.000000	0.989465	0.990000	1	0.980000	1.000000
PODXL	5420	broad.mit.edu	37	7	131196176	131196176	+	Silent	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr7:131196176C>T	ENST00000378555.3	-	2	364	c.117G>A	c.(115-117)acG>acA	p.T39T	PODXL_ENST00000322985.9_Silent_p.T39T|PODXL_ENST00000465001.1_5'UTR|PODXL_ENST00000537928.1_Silent_p.T39T|PODXL_ENST00000541194.1_Silent_p.T41T			O00592	PODXL_HUMAN	podocalyxin-like			24	Melanoma(18;0.162)				TAGATGAGTCCGTAGTAGTCT	0.527000																								0							SO:0001819	synonymous_variant			ENST00000378555.3	0	1	hg19	CCDS34755.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	PODXL-005	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000337627.2	0	0	0	52	219	0	113	0	2.501450e-01	1	4	0	113	2								1	1.000000	50	215	0	109	2								-2.474241	0	1	0	0		1	1	2	3	2.075402	0	0.470000	1.900000	0.472479	0.810000	6.300000e-01	1.000000	1.000000	0.825963	0.810000	0	0.720000	0.930000
POU6F2	11281	broad.mit.edu	37	7	39379547	39379547	+	Missense_Mutation	SNP	C	C	T	rs144939808		TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr7:39379547C>T	ENST00000403058.1	+	6	972	c.818C>T	c.(817-819)cCg>cTg	p.P273L	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000518318.2_Missense_Mutation_p.P273L|POU6F2_ENST00000559001.1_Missense_Mutation_p.P265L	NM_001166018.1|NM_007252.3	NP_001159490.1|NP_009183.3	P78424	PO6F2_HUMAN	POU class 6 homeobox 2			42					tccagccccCCGCAGAAACCT	0.627000																								0							SO:0001583	missense			ENST00000403058.1	0	1	hg19	CCDS34620.2	.	.	.	.	.	.	.	.	.	.	C	15.07	2.722810	0.48728	0.0	3.49E-4	ENSG00000106536	ENST00000403058;ENST00000518318	T;D	0.85702	0.99;-2.02	4.66	3.76	0.43208	.	2586.510000	0.00166	N	0.000001	D	0.86016	0.5832	L	0.55481	1.735	0.46678	D	0.999155	P;P	0.45011	0.848;0.725	B;B	0.41619	0.361;0.074	T	0.71580	-0.4550	10	0.49607	T	0.09	.	13.9533	0.64131	0.1534:0.8466:0.0:0.0	.	273;273	P78424-2;P78424	.;PO6F2_HUMAN	L	273	ENSP00000384004:P273L;ENSP00000430514:P273L	ENSP00000384004:P273L	P	+	2	0	POU6F2	39346072	1.000000	0.71417	0.992000	0.48379	0.949000	0.60115	5.936000	0.70153	0.916000	0.36871	0.557000	0.71058	CCG		TCGA-FB-AAPQ-01A-11D-A40W-08	POU6F2-002	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000320146.3	0	0	0	43	186	0	65	0	0	0	1	0	65	2								1	1.000000	42	181	0	63	2								-2.653406	1	1	121412	58	49	1	1	2	3	2.075402	0	0.470000	1.900000	0.472479	0.800000	6.000000e-01	1.000000	1.000000	0.809811	0.800000	0	0.690000	0.920000
SYBU	55638	broad.mit.edu	37	8	110588134	110588134	+	Silent	SNP	C	C	T			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr8:110588134C>T	ENST00000422135.1	-	8	1508	c.993G>A	c.(991-993)agG>agA	p.R331R	SYBU_ENST00000527707.1_5'Flank|SYBU_ENST00000529175.1_Silent_p.R125R|SYBU_ENST00000533171.1_Silent_p.R331R|SYBU_ENST00000408908.2_Silent_p.R331R|SYBU_ENST00000529690.1_Silent_p.R201R|SYBU_ENST00000440310.1_Silent_p.R331R|SYBU_ENST00000424158.2_Silent_p.R336R|SYBU_ENST00000532779.1_Silent_p.R263R|SYBU_ENST00000408889.3_Silent_p.R212R|SYBU_ENST00000276646.9_Silent_p.R331R|SYBU_ENST00000446070.2_Silent_p.R330R|SYBU_ENST00000433638.1_Silent_p.R331R|SYBU_ENST00000419099.1_Silent_p.R330R|SYBU_ENST00000528331.1_Silent_p.R212R|SYBU_ENST00000399066.3_Silent_p.R328R|SYBU_ENST00000528647.1_Silent_p.R330R|SYBU_ENST00000533895.1_Silent_p.R330R|SYBU_ENST00000533065.1_Silent_p.R212R	NM_001099744.1	NP_001093214.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)			30					TAATCTCTTTCCTGGCTTCTT	0.488000																								0							SO:0001819	synonymous_variant			ENST00000422135.1	0	1	hg19	CCDS47912.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	SYBU-204	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000385501.1	0	0	0	18	405	1	179	0	6.008649e-02	0	9	1	179	2								1	0.999981	17	400	0	178	2								-3.277863	1	1	0	0		1	1	2	3	2.064278	0	0.470000	1.900000	0.472479	0.180000	1.000000e-01	0.290000	0.180000	0.198557	0.180000	0	0.140000	0.240000
ANK1	286	broad.mit.edu	37	8	41563703	41563703	+	Silent	SNP	A	A	G			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr8:41563703A>G	ENST00000347528.4	-	18	2138	c.2055T>C	c.(2053-2055)gaT>gaC	p.D685D	ANK1_ENST00000396945.1_Silent_p.D685D|ANK1_ENST00000289734.7_Silent_p.D685D|ANK1_ENST00000396942.1_Silent_p.D685D|ANK1_ENST00000379758.2_Silent_p.D685D|ANK1_ENST00000352337.4_Silent_p.D685D|ANK1_ENST00000265709.8_Silent_p.D718D	NM_020475.2|NM_020476.2|NM_020477.2	NP_065208.2|NP_065209.2|NP_065210.2	P16157	ANK1_HUMAN	ankyrin 1, erythrocytic			122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)		TGATCAGCACATCTGCCACTG	0.522000																								0							SO:0001819	synonymous_variant			ENST00000347528.4	0	1	hg19	CCDS6119.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	ANK1-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000317297.1	0	0	0	66	190	0	113	0	6.818114e-02	1	1	0	113	2								1	1.000000	64	187	1	112	10								-5.280714	1	1	0	0		1	1	2	3	2.064278	0	0.470000	1.900000	0.472479	0.990000	8.800000e-01	1.000000	1.000000	0.989248	0.990000	1	0.980000	1.000000
FAM129B	64855	broad.mit.edu	37	9	130272530	130272530	+	Silent	SNP	G	G	C			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chr9:130272530G>C	ENST00000373312.3	-	9	1269	c.1056C>G	c.(1054-1056)gtC>gtG	p.V352V	FAM129B_ENST00000468379.1_Intron|FAM129B_ENST00000373314.3_Silent_p.V339V	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B			25					GGCTGGTGGGGACCATCAGGG	0.607000																								0							SO:0001819	synonymous_variant			ENST00000373312.3	0	1	hg19	CCDS35145.1																																																																																				TCGA-FB-AAPQ-01A-11D-A40W-08	FAM129B-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000054196.1	0	0	0	93	401	0	162	1	1	117	152	0	162	2								1	1.000000	92	393	0	160	2								-20.000000	1	1	0	0		1	1	2	3	2.080301	0	0.470000	1.900000	0.474936	0.800000	6.600000e-01	1.000000	0.810000	0.817380	0.800000	0	0.730000	0.900000
ELK1	2002	broad.mit.edu	37	X	47500789	47500789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FB-AAPQ-01A-11D-A40W-08	TCGA-FB-AAPQ-11A-11D-A40W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	99ad1f02-6c55-4c69-863d-6b47298b0c43	29a5cf73-0904-450f-ac74-6b46dfb2e4f4	g.chrX:47500789G>A	ENST00000247161.3	-	2	151	c.52C>T	c.(52-54)Caa>Taa	p.Q18*	ELK1_ENST00000376983.3_Nonsense_Mutation_p.Q18*|ELK1_ENST00000592066.1_5'UTR|ELK1_ENST00000343894.4_Nonsense_Mutation_p.Q18*	NM_005229.4	NP_005220.2	P19419	ELK1_HUMAN	ELK1, member of ETS oncogene family			10					CCATTGCCTTGCTCTCTCAGC	0.597000																								0							SO:0001587	stop_gained			ENST00000247161.3	0	1	hg19	CCDS14283.1	.	.	.	.	.	.	.	.	.	.	G	35	5.415103	0.96092	.	.	ENSG00000126767	ENST00000247161;ENST00000376983;ENST00000343894	.	.	.	4.89	4.89	0.63831	.	0.000000	0.85682	D	0.000000	.	.	.	.	.	.	0.80722	A	1	.	.	.	.	.	.	.	.	.	.	0.05833	T	0.94	.	14.323	0.66499	0.0:0.0:1.0:0.0	.	.	.	.	X	18	.	ENSP00000247161:Q18X	Q	-	1	0	ELK1	47385733	1.000000	0.71417	1.000000	0.80357	0.984000	0.73092	6.239000	0.72356	2.255000	0.74692	0.506000	0.49869	CAA		TCGA-FB-AAPQ-01A-11D-A40W-08	ELK1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000056436.1	0	0	0	51	37	0	30	1	9.999995e-01	13	12	0	30	2								1	1.000000	50	37	0	30	2								-20.000000	1	1	0	0		1	0	1	1			0.470000	1.900000	0.470000	0.960000	8.500000e-01	1.000000	0.990000	0.961917	0.960000	1	0.920000	1.000000