Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
TMEM51	55092	broad.mit.edu	37	1	15545933	15545933	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:15545933G>A	uc001avw.3	+	4	975	c.456G>A	c.(454-456)CCG>CCA	p.P152P	TMEM51_uc010obk.1_Silent_p.P152P|TMEM51_uc001avz.2_3'UTR|TMEM51_uc001avy.2_Silent_p.P152P|TMEM51_uc001avx.2_Silent_p.P152P	NM_001136216	NP_001129688	Q9NW97	TMM51_HUMAN	transmembrane protein 51	152						integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		AGCAGAACCCGAGGTTGAGCA	0.582													17	94	---	---	---	---	PASS
NBPF3	84224	broad.mit.edu	37	1	21797204	21797204	+	Missense_Mutation	SNP	G	T	T	rs72872292	byFrequency	TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:21797204G>T	uc001ber.2	+	4	773	c.423G>T	c.(421-423)GAG>GAT	p.E141D	NBPF3_uc001bes.2_Missense_Mutation_p.E85D|NBPF3_uc009vqb.2_Missense_Mutation_p.E141D|NBPF3_uc010odm.1_Missense_Mutation_p.E71D	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	141	Potential.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTGCAGAGGAGCTCGGGCAAG	0.547													11	68	---	---	---	---	PASS
PODN	127435	broad.mit.edu	37	1	53535731	53535731	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:53535731C>T	uc001cuv.2	+	2	355	c.348C>T	c.(346-348)TGC>TGT	p.C116C	PODN_uc001cuw.2_Silent_p.C97C|PODN_uc010onr.1_Silent_p.C97C|PODN_uc010ons.1_Silent_p.C116C	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	68	LRRNT.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						CGGTCAGCTGCCCCCGAGACT	0.667													6	39	---	---	---	---	PASS
INADL	10207	broad.mit.edu	37	1	62330011	62330011	+	Missense_Mutation	SNP	C	A	A	rs139134153	byFrequency	TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:62330011C>A	uc001dab.2	+	20	2655	c.2541C>A	c.(2539-2541)AGC>AGA	p.S847R	INADL_uc009waf.1_Missense_Mutation_p.S847R|INADL_uc001daa.2_Missense_Mutation_p.S847R|INADL_uc001dad.3_Missense_Mutation_p.S544R|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	847					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TAGAGCAAAGCAAGGAGGCCT	0.368													6	97	---	---	---	---	PASS
SFRS11	9295	broad.mit.edu	37	1	70700378	70700378	+	Splice_Site	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:70700378G>T	uc001des.2	+	5	572	c.448_splice	c.e5-1	p.I150_splice	SFRS11_uc001det.2_Splice_Site_p.I150_splice|SFRS11_uc001deu.2_Splice_Site_p.I150_splice|SFRS11_uc001dev.2_Splice_Site|SFRS11_uc001dew.2_Splice_Site_p.I90_splice	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CCATTTCACAGATTGGCGCTG	0.338													29	102	---	---	---	---	PASS
ABCA4	24	broad.mit.edu	37	1	94480239	94480239	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:94480239C>T	uc001dqh.2	-	38	5424	c.5320G>A	c.(5320-5322)GTC>ATC	p.V1774I	ABCA4_uc009wdp.1_Missense_Mutation_p.V42I	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1774	Helical; (Potential).				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ATGGGAATGACCGCCCATCTG	0.478													37	171	---	---	---	---	PASS
ISG20L2	81875	broad.mit.edu	37	1	156694041	156694041	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:156694041T>A	uc001fps.1	-	2	1108	c.847A>T	c.(847-849)ACC>TCC	p.T283S	ISG20L2_uc001fpt.1_Missense_Mutation_p.T283S	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	283	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATATGGGAGGTGTCACGGGTG	0.542													24	113	---	---	---	---	PASS
FCRL5	83416	broad.mit.edu	37	1	157494301	157494301	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:157494301C>A	uc001fqu.2	-	10	2165	c.2007G>T	c.(2005-2007)CAG>CAT	p.Q669H	FCRL5_uc009wsm.2_Missense_Mutation_p.Q669H|FCRL5_uc010phv.1_Missense_Mutation_p.Q669H|FCRL5_uc010phw.1_Missense_Mutation_p.Q584H	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	669	Extracellular (Potential).|Ig-like C2-type 7.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CCACCACAGCCTGGGCCCTGG	0.527													18	67	---	---	---	---	PASS
OR6N1	128372	broad.mit.edu	37	1	158735878	158735878	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:158735878C>A	uc010piq.1	-	1	595	c.595G>T	c.(595-597)GAT>TAT	p.D199Y		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATAACAAAATCTACTAGGACA	0.483													40	141	---	---	---	---	PASS
F5	2153	broad.mit.edu	37	1	169510281	169510281	+	Silent	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:169510281G>T	uc001ggg.1	-	13	4192	c.4047C>A	c.(4045-4047)TCC>TCA	p.S1349S		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1349	2-19.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CGAGGGCTGGGGAAAGGTTTG	0.517													59	205	---	---	---	---	PASS
FASLG	356	broad.mit.edu	37	1	172628635	172628635	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:172628635C>A	uc001gis.2	+	1	451	c.294C>A	c.(292-294)GGC>GGA	p.G98G	FASLG_uc001git.2_Silent_p.G98G	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	98	Helical; Signal-anchor for type II membrane protein; (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						TAGGATTGGGCCTGGGGATGT	0.512													18	59	---	---	---	---	PASS
PAPPA2	60676	broad.mit.edu	37	1	176709279	176709279	+	Silent	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:176709279G>T	uc001gkz.2	+	14	5262	c.4098G>T	c.(4096-4098)TCG>TCT	p.S1366S	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1366					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTGGTCTTTCGGCTCCCAGTA	0.507													22	64	---	---	---	---	PASS
ASTN1	460	broad.mit.edu	37	1	176903472	176903472	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:176903472G>A	uc001glc.2	-	16	2699	c.2487C>T	c.(2485-2487)CTC>CTT	p.L829L	ASTN1_uc001glb.1_Silent_p.L829L|ASTN1_uc001gld.1_Silent_p.L829L	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	837					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GAGCATTGCTGAGGGCTATGG	0.522													11	52	---	---	---	---	PASS
FAM20B	9917	broad.mit.edu	37	1	179019460	179019460	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:179019460G>A	uc001gmc.2	+	3	717	c.424G>A	c.(424-426)GAT>AAT	p.D142N		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	142	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						TGCTGGTTATGATAGACACAA	0.448													61	165	---	---	---	---	PASS
C1orf125	126859	broad.mit.edu	37	1	179398712	179398712	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:179398712G>C	uc001gmo.2	+	13	1417	c.1290G>C	c.(1288-1290)TGG>TGC	p.W430C	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.W218C|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.W430C	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	430											0						AAAAAGGCTGGAATAAATACA	0.323													9	52	---	---	---	---	PASS
TP53BP2	7159	broad.mit.edu	37	1	224009057	224009057	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:224009057C>A	uc010pvb.1	-	2	332	c.40G>T	c.(40-42)GTG>TTG	p.V14L	TP53BP2_uc001hod.2_5'UTR	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	8					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		CTGAGATACACGGTAAGAAAC	0.413													64	270	---	---	---	---	PASS
ITPKB	3707	broad.mit.edu	37	1	226822451	226822451	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:226822451C>G	uc010pvo.1	-	8	3102	c.2762G>C	c.(2761-2763)CGG>CCG	p.R921P		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	921							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				GCCATCCTCCCGGTTCCCCTC	0.632													11	41	---	---	---	---	PASS
GUK1	2987	broad.mit.edu	37	1	228335335	228335335	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:228335335G>C	uc001hsh.2	+	7	713	c.410G>C	c.(409-411)CGC>CCC	p.R137P	GUK1_uc001hsi.2_Missense_Mutation_p.R158P|GUK1_uc001hsj.2_Missense_Mutation_p.R77P|GUK1_uc010pvv.1_Missense_Mutation_p.R137P|GJC2_uc001hsk.2_5'Flank	NM_000858	NP_000849	Q16774	KGUA_HUMAN	guanylate kinase 1 isoform b	137	Guanylate kinase-like.				nucleobase, nucleoside and nucleotide interconversion|purine nucleotide metabolic process	cytosol	ATP binding|guanylate kinase activity				0		Prostate(94;0.0405)				CTGCGGCAGCGCAACACTGAA	0.657													13	38	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237794791	237794791	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:237794791G>T	uc001hyl.1	+	42	6625	c.6505G>T	c.(6505-6507)GAG>TAG	p.E2169*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2169	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGGGATGCACGAGACTGTGAT	0.458													6	25	---	---	---	---	PASS
SMYD3	64754	broad.mit.edu	37	1	246498753	246498753	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:246498753C>T	uc001ibl.2	-	3	347	c.252G>A	c.(250-252)AAG>AAA	p.K84K	SMYD3_uc001ibk.2_Silent_p.K25K	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	84	MYND-type.					cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TGCATTCCCGCTTGTGGTCTG	0.398													29	177	---	---	---	---	PASS
OR2C3	81472	broad.mit.edu	37	1	247695727	247695727	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr1:247695727G>A	uc009xgy.2	-	2	449	c.87C>T	c.(85-87)TTC>TTT	p.F29F	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AGACAACTATGAAGAGGACAG	0.463													31	71	---	---	---	---	PASS
SNX17	9784	broad.mit.edu	37	2	27596776	27596776	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:27596776A>T	uc002rkg.1	+	5	592	c.370A>T	c.(370-372)AGC>TGC	p.S124C	SNX17_uc010ylj.1_Missense_Mutation_p.S104C|SNX17_uc010ylk.1_5'UTR|SNX17_uc010eza.1_5'UTR|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_5'UTR|SNX17_uc010yll.1_5'UTR|SNX17_uc010ylm.1_5'UTR|SNX17_uc010yln.1_Missense_Mutation_p.S112C|SNX17_uc010ylo.1_Missense_Mutation_p.S42C|SNX17_uc010ylp.1_Missense_Mutation_p.S99C|SNX17_uc010ylq.1_5'UTR	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	124	Ras-associating.				cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTGCTGCTCAGCAACGGGCA	0.557													7	41	---	---	---	---	PASS
PLB1	151056	broad.mit.edu	37	2	28741349	28741349	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:28741349C>T	uc002rmb.1	+	3	134	c.134C>T	c.(133-135)CCA>CTA	p.P45L	PLB1_uc010ezj.1_Missense_Mutation_p.P45L	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	45	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					AAGAATTCTCCATTCCCATGC	0.408													45	95	---	---	---	---	PASS
EHD3	30845	broad.mit.edu	37	2	31472300	31472300	+	Silent	SNP	G	A	A	rs138864640		TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:31472300G>A	uc002rnu.2	+	3	1076	c.468G>A	c.(466-468)GGG>GGA	p.G156G	EHD3_uc010ymt.1_Silent_p.G156G	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	156					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					ACACACCAGGGATCCTCTCTG	0.592													15	56	---	---	---	---	PASS
GGCX	2677	broad.mit.edu	37	2	85780514	85780514	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:85780514G>A	uc002sps.2	-	8	1102	c.996C>T	c.(994-996)CCC>CCT	p.P332P	GGCX_uc010yss.1_Silent_p.P171P|GGCX_uc010yst.1_Silent_p.P275P	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	332	Cytoplasmic (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CTGCCTTGAGGGGCAACAGTT	0.617													25	123	---	---	---	---	PASS
VWA3B	200403	broad.mit.edu	37	2	98846666	98846666	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:98846666C>A	uc002syo.2	+	16	2568	c.2304C>A	c.(2302-2304)CAC>CAA	p.H768Q	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.H287Q|VWA3B_uc002sym.2_Missense_Mutation_p.H768Q|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.H425Q|VWA3B_uc002syp.1_Missense_Mutation_p.H160Q|VWA3B_uc002syq.1_Missense_Mutation_p.H44Q|VWA3B_uc002syr.1_Missense_Mutation_p.H85Q	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	768										ovary(3)|large_intestine(2)|skin(1)	6						AAGTCCTTCACGCAGGTATCA	0.383													11	62	---	---	---	---	PASS
ACOXL	55289	broad.mit.edu	37	2	111598951	111598951	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:111598951G>C	uc002tgr.3	+	10	981	c.757G>C	c.(757-759)GGG>CGG	p.G253R	ACOXL_uc010fkc.2_Missense_Mutation_p.G253R|ACOXL_uc010yxk.1_Missense_Mutation_p.G253R	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	253					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						ATTACAGCTTGGGTTGACGAT	0.313													5	32	---	---	---	---	PASS
DPP10	57628	broad.mit.edu	37	2	116593772	116593772	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:116593772G>T	uc002tla.1	+	22	2447	c.1990G>T	c.(1990-1992)GAT>TAT	p.D664Y	DPP10_uc002tlb.1_Missense_Mutation_p.D614Y|DPP10_uc002tlc.1_Missense_Mutation_p.D660Y|DPP10_uc002tle.2_Missense_Mutation_p.D668Y|DPP10_uc002tlf.1_Missense_Mutation_p.D657Y	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	664	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTTAAAATCAGATGAAAAGCT	0.294													11	57	---	---	---	---	PASS
TMEM37	140738	broad.mit.edu	37	2	120194538	120194538	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:120194538C>T	uc002tly.2	+	2	129	c.95C>T	c.(94-96)ACG>ATG	p.T32M		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	32	Helical; (Potential).					integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						CTCATCATCACGTGTGTGGCC	0.612													27	124	---	---	---	---	PASS
POTEE	445582	broad.mit.edu	37	2	131976176	131976176	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:131976176C>T	uc002tsn.2	+	1	253	c.201C>T	c.(199-201)CAC>CAT	p.H67H	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	67							ATP binding				0						GGTGCCACCACTGCTTCCCCT	0.582													58	222	---	---	---	---	PASS
CCDC74A	90557	broad.mit.edu	37	2	132288288	132288288	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:132288288G>T	uc002tta.2	+	3	484	c.432G>T	c.(430-432)AGG>AGT	p.R144S	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	144										skin(1)	1						GGACACACAGGCCAGGAGGCA	0.652													13	117	---	---	---	---	PASS
FAP	2191	broad.mit.edu	37	2	163059422	163059422	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:163059422A>G	uc002ucd.2	-	14	1391	c.1183T>C	c.(1183-1185)TGG>CGG	p.W395R	FAP_uc010zct.1_Missense_Mutation_p.W370R|FAP_uc010fpd.2_Intron	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	395	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						ATGGCCTCCCACTTGCCACTT	0.373													26	138	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	168099528	168099528	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:168099528C>A	uc002udx.2	+	8	1644	c.1626C>A	c.(1624-1626)GCC>GCA	p.A542A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.A367A|XIRP2_uc010fpq.2_Silent_p.A320A|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	367	Xin 1.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGCAACAAGCCCGGTATGTTT	0.368													12	48	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179517248	179517248	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:179517248C>T	uc010zfg.1	-	156	31986	c.31762G>A	c.(31762-31764)GTT>ATT	p.V10588I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_5'Flank|TTN_uc002umx.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11515							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGGAACAACTTCTTTCGGA	0.368													15	99	---	---	---	---	PASS
ZDBF2	57683	broad.mit.edu	37	2	207175031	207175031	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:207175031C>A	uc002vbp.2	+	5	6029	c.5779C>A	c.(5779-5781)CCT>ACT	p.P1927T		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1927							nucleic acid binding|zinc ion binding			ovary(3)	3						AGAGAGGCCTCCTAAGCAAAA	0.443													20	64	---	---	---	---	PASS
ZDBF2	57683	broad.mit.edu	37	2	207175032	207175032	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:207175032C>A	uc002vbp.2	+	5	6030	c.5780C>A	c.(5779-5781)CCT>CAT	p.P1927H		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1927							nucleic acid binding|zinc ion binding			ovary(3)	3						GAGAGGCCTCCTAAGCAAAAG	0.438													20	66	---	---	---	---	PASS
PTH2R	5746	broad.mit.edu	37	2	209324667	209324667	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:209324667C>T	uc002vdb.2	+	9	1175	c.962C>T	c.(961-963)CCG>CTG	p.P321L	PTH2R_uc010zjb.1_Missense_Mutation_p.P332L	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	321	Helical; Name=5; (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TATCAAGCACCGATCTTAGCA	0.388													7	177	---	---	---	---	PASS
CUL3	8452	broad.mit.edu	37	2	225346608	225346608	+	Splice_Site	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:225346608C>T	uc002vny.2	-	14	2413	c.2029_splice	c.e14+1	p.V677_splice	CUL3_uc010zls.1_Splice_Site_p.V611_splice|CUL3_uc010fwy.1_Splice_Site_p.V683_splice	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3						cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATTCCAGATACCTGTTTGAAT	0.269													24	119	---	---	---	---	PASS
CUL3	8452	broad.mit.edu	37	2	225376227	225376227	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:225376227C>T	uc002vny.2	-	6	1111	c.727G>A	c.(727-729)GAA>AAA	p.E243K	CUL3_uc010zls.1_Missense_Mutation_p.E177K|CUL3_uc010fwy.1_Missense_Mutation_p.E249K	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	243					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCTATTTCTTCATTAATTCTA	0.323													26	163	---	---	---	---	PASS
PDCD1	5133	broad.mit.edu	37	2	242795003	242795003	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr2:242795003C>T	uc002wcq.3	-	2	274	c.206G>A	c.(205-207)CGC>CAC	p.R69H	PDCD1_uc010fzs.2_5'UTR|PDCD1_uc010fzt.2_Intron	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	69	Ig-like V-type.|Extracellular (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GGGGCTCATGCGGTACCAGTT	0.637													8	32	---	---	---	---	PASS
KIAA1407	57577	broad.mit.edu	37	3	113761550	113761550	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:113761550C>A	uc003eax.2	-	4	562	c.415G>T	c.(415-417)GAT>TAT	p.D139Y	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.D117Y|KIAA1407_uc011bip.1_Missense_Mutation_p.D126Y	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	139										ovary(2)	2						AAGTTCTTACCATCAAACTTG	0.318													9	73	---	---	---	---	PASS
ZNF80	7634	broad.mit.edu	37	3	113955592	113955592	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:113955592G>T	uc010hqo.2	-	1	834	c.330C>A	c.(328-330)TGC>TGA	p.C110*	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	110	C2H2-type 3; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				AGACCTTCCCGCACTCCACGC	0.547													10	32	---	---	---	---	PASS
ARHGAP31	57514	broad.mit.edu	37	3	119133421	119133421	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:119133421T>G	uc003ecj.3	+	12	3177	c.2645T>G	c.(2644-2646)GTA>GGA	p.V882G		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	882					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						ACCCATTCAGTACAGGAGCCT	0.542													31	117	---	---	---	---	PASS
KALRN	8997	broad.mit.edu	37	3	124209608	124209608	+	Silent	SNP	G	T	T	rs139928910		TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:124209608G>T	uc003ehg.2	+	30	4585	c.4458G>T	c.(4456-4458)CCG>CCT	p.P1486P	KALRN_uc010hrv.1_Silent_p.P1477P|KALRN_uc003ehf.1_Silent_p.P1486P|KALRN_uc011bjy.1_Silent_p.P1477P	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1486	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TGTGGGACCCGAAGTCGCTGA	0.507													22	111	---	---	---	---	PASS
NPHP3	27031	broad.mit.edu	37	3	132423171	132423171	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:132423171C>G	uc003epe.1	-	9	1472	c.1395G>C	c.(1393-1395)TTG>TTC	p.L465F	NPHP3_uc003epf.1_Missense_Mutation_p.L220F	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	465					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CCTCACTGCCCAAATCCTTAG	0.388													15	393	---	---	---	---	PASS
VPS8	23355	broad.mit.edu	37	3	184586825	184586825	+	Splice_Site	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:184586825G>T	uc003fpb.1	+	18	1762	c.1591_splice	c.e18+1	p.G531_splice	VPS8_uc010hyd.1_Splice_Site_p.G531_splice	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GCAGTAGTGGGTGAGTAGGCA	0.458													28	16	---	---	---	---	PASS
BCL6	604	broad.mit.edu	37	3	187442826	187442826	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr3:187442826T>C	uc003frp.3	-	9	2337	c.1880A>G	c.(1879-1881)GAG>GGG	p.E627G	BCL6_uc011bsf.1_Missense_Mutation_p.E571G|BCL6_uc010hza.2_Missense_Mutation_p.E525G|BCL6_uc003frq.1_Missense_Mutation_p.E627G	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	627					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		ATAGGGCTTCTCACCAGTGTG	0.572			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								82	222	---	---	---	---	PASS
ADAD1	132612	broad.mit.edu	37	4	123336548	123336548	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr4:123336548A>G	uc003ieo.2	+	11	1496	c.1264A>G	c.(1264-1266)AGT>GGT	p.S422G	ADAD1_uc003iep.2_Missense_Mutation_p.S411G|ADAD1_uc003ieq.2_Missense_Mutation_p.S404G	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	422	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TGGGAATTGCAGTGATACCAG	0.333													20	74	---	---	---	---	PASS
BBS12	166379	broad.mit.edu	37	4	123663366	123663366	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr4:123663366G>T	uc003ieu.2	+	2	512	c.319G>T	c.(319-321)GTC>TTC	p.V107F		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	107					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						TCATCTTGGTGTCCCCATTTC	0.373									Bardet-Biedl_syndrome				31	96	---	---	---	---	PASS
BBS12	166379	broad.mit.edu	37	4	123663906	123663906	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr4:123663906G>T	uc003ieu.2	+	2	1052	c.859G>T	c.(859-861)GAA>TAA	p.E287*		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	287					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						GAAGTTAGTAGAAGAAGCAGT	0.388									Bardet-Biedl_syndrome				16	47	---	---	---	---	PASS
PCDH10	57575	broad.mit.edu	37	4	134071494	134071494	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr4:134071494A>T	uc003iha.2	+	1	1025	c.199A>T	c.(199-201)AAC>TAC	p.N67Y	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.N67Y	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CTTAGACCTCAACCTGGAGAC	0.532													29	99	---	---	---	---	PASS
TKTL2	84076	broad.mit.edu	37	4	164393523	164393523	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr4:164393523G>T	uc003iqp.3	-	1	1525	c.1364C>A	c.(1363-1365)GCC>GAC	p.A455D		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	455						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTCGAGATGGCATCACTTGG	0.478													30	70	---	---	---	---	PASS
MAP1B	4131	broad.mit.edu	37	5	71493130	71493130	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr5:71493130G>A	uc003kbw.3	+	5	4189	c.3948G>A	c.(3946-3948)AAG>AAA	p.K1316K	MAP1B_uc010iyw.1_Silent_p.K1333K|MAP1B_uc010iyx.1_Silent_p.K1190K|MAP1B_uc010iyy.1_Silent_p.K1190K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1316						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTGAGGACAAGACTCTGGAAG	0.498													9	32	---	---	---	---	PASS
FAM170A	340069	broad.mit.edu	37	5	118968463	118968463	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr5:118968463G>C	uc003ksm.2	+	2	301	c.91G>C	c.(91-93)GAT>CAT	p.D31H	FAM170A_uc003ksl.2_Missense_Mutation_p.D31H|FAM170A_uc003ksn.2_Missense_Mutation_p.D31H|FAM170A_uc003kso.2_Intron	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	31						intracellular	zinc ion binding			skin(1)	1						GTCCCAAGAGGATGCCCTGCA	0.433													25	56	---	---	---	---	PASS
ATP10B	23120	broad.mit.edu	37	5	160097670	160097670	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr5:160097670C>G	uc003lym.1	-	7	1322	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	ATP10B_uc003lyp.2_Missense_Mutation_p.E159Q|ATP10B_uc011deg.1_Missense_Mutation_p.E203Q|ATP10B_uc003lyo.2_Missense_Mutation_p.E131Q	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	159	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAGGTCTGCTCTTTTCTTGGG	0.463													31	70	---	---	---	---	PASS
LRFN2	57497	broad.mit.edu	37	6	40399704	40399704	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:40399704G>C	uc003oph.1	-	2	1614	c.1149C>G	c.(1147-1149)AGC>AGG	p.S383R		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	383	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGTGCTGTTGCTGAGGTGTG	0.652													11	39	---	---	---	---	PASS
EYS	346007	broad.mit.edu	37	6	66204811	66204811	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:66204811G>C	uc011dxu.1	-	4	1031	c.493C>G	c.(493-495)CTA>GTA	p.L165V	EYS_uc003peq.2_Missense_Mutation_p.L165V|EYS_uc003per.1_Missense_Mutation_p.L165V|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	165					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GTCACATTTAGTCGAAGTCCC	0.428													24	64	---	---	---	---	PASS
IMPG1	3617	broad.mit.edu	37	6	76715078	76715078	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:76715078T>G	uc003pik.1	-	10	1191	c.1061A>C	c.(1060-1062)GAC>GCC	p.D354A		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	354					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCTTTTGAGGTCTGTAGCTGT	0.423													28	106	---	---	---	---	PASS
NT5E	4907	broad.mit.edu	37	6	86181076	86181076	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:86181076C>A	uc003pko.3	+	3	1240	c.684C>A	c.(682-684)CTC>CTA	p.L228L	NT5E_uc003pkn.2_Silent_p.L228L|NT5E_uc010kbr.2_Silent_p.L228L	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	228					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	TGGATAAACTCATCGCTCAGA	0.408													19	86	---	---	---	---	PASS
ORC3L	23595	broad.mit.edu	37	6	88331094	88331094	+	Missense_Mutation	SNP	A	G	G	rs147755470		TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:88331094A>G	uc003pmh.2	+	10	1054	c.1010A>G	c.(1009-1011)TAT>TGT	p.Y337C	ORC3L_uc011dzl.1_Missense_Mutation_p.Y337C|ORC3L_uc011dzm.1_Missense_Mutation_p.Y337C|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.Y337C|ORC3L_uc003pmi.2_Missense_Mutation_p.Y299C|ORC3L_uc011dzo.1_Missense_Mutation_p.Y194C|ORC3L_uc011dzp.1_Missense_Mutation_p.Y194C	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	337					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		GAGCATTTCTATTCCCAGCCC	0.333													8	128	---	---	---	---	PASS
MANEA	79694	broad.mit.edu	37	6	96053766	96053766	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:96053766A>T	uc003poo.1	+	5	1014	c.874A>T	c.(874-876)AAT>TAT	p.N292Y		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	292	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		GAGTATTCGCAATTCTCCTTA	0.373													29	80	---	---	---	---	PASS
C6orf204	387119	broad.mit.edu	37	6	118887060	118887060	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:118887060T>C	uc003pxz.1	-	3	1240	c.652A>G	c.(652-654)ATA>GTA	p.I218V	C6orf204_uc003pya.1_Missense_Mutation_p.I221V|C6orf204_uc003pyb.2_Missense_Mutation_p.I218V|C6orf204_uc011ebj.1_Missense_Mutation_p.I116V|C6orf204_uc003pyc.2_Missense_Mutation_p.I221V|C6orf204_uc011ebl.1_Missense_Mutation_p.I116V	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	218						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTTTTATTTATTTCCTTGTCC	0.423													10	158	---	---	---	---	PASS
TCP10	6953	broad.mit.edu	37	6	167786681	167786681	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr6:167786681G>A	uc003qvv.1	-	8	1169	c.957C>T	c.(955-957)CCC>CCT	p.P319P	TCP10_uc003qvu.2_Intron	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	346						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		CCTGTCTGGAGGGAGCGGCGT	0.537													21	114	---	---	---	---	PASS
GLCCI1	113263	broad.mit.edu	37	7	8095089	8095089	+	Silent	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:8095089A>G	uc003srk.2	+	4	1282	c.723A>G	c.(721-723)CTA>CTG	p.L241L		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	241	Potential.										0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GGCAGCAACTACAACGCAGTA	0.408													19	97	---	---	---	---	PASS
ADCYAP1R1	117	broad.mit.edu	37	7	31126093	31126093	+	Silent	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:31126093G>T	uc003tca.1	+	10	988	c.765G>T	c.(763-765)CTG>CTT	p.L255L	ADCYAP1R1_uc003tcb.1_Silent_p.L234L|ADCYAP1R1_uc003tcc.1_Silent_p.L255L|ADCYAP1R1_uc003tcd.1_Silent_p.L255L|ADCYAP1R1_uc003tce.1_Silent_p.L255L|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	255	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TCACTCTGCTGGTGGAGACCT	0.527													13	72	---	---	---	---	PASS
PDE1C	5137	broad.mit.edu	37	7	31793118	31793118	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:31793118G>A	uc003tcm.1	-	18	2479	c.2010C>T	c.(2008-2010)AGC>AGT	p.S670S	PDE1C_uc003tcn.1_Silent_p.S670S|PDE1C_uc003tco.1_Silent_p.S730S	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	670					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GTGCATAGGAGCTAGATGCGT	0.468													36	142	---	---	---	---	PASS
POU6F2	11281	broad.mit.edu	37	7	39125632	39125632	+	Splice_Site	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:39125632G>T	uc003thb.1	+	2	232	c.190_splice	c.e2+1	p.G64_splice	POU6F2_uc010kxo.2_Splice_Site_p.G56_splice	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						AAGCTCTTCGGTAAGTCTGTC	0.502													13	42	---	---	---	---	PASS
CDK13	8621	broad.mit.edu	37	7	40102656	40102656	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:40102656A>G	uc003thh.3	+	9	3019	c.2737A>G	c.(2737-2739)ATA>GTA	p.I913V	CDK13_uc003thi.3_Missense_Mutation_p.I913V|CDK13_uc011kbf.1_Missense_Mutation_p.I299V|CDK13_uc003thj.2_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	913	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TAAAAAACCTATATTTCAAGC	0.348													37	94	---	---	---	---	PASS
CAMK2B	816	broad.mit.edu	37	7	44286779	44286779	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:44286779C>A	uc003tkq.2	-	6	564	c.354G>T	c.(352-354)CAG>CAT	p.Q118H	CAMK2B_uc003tkp.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tkx.2_Missense_Mutation_p.Q118H|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tks.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tku.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tkv.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tkt.2_Missense_Mutation_p.Q118H|CAMK2B_uc003tkw.2_Missense_Mutation_p.Q118H|CAMK2B_uc010kyc.2_Missense_Mutation_p.Q118H	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	118	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CCAGGATCTGCTGGATACAGT	0.602													8	40	---	---	---	---	PASS
MGC26647	219557	broad.mit.edu	37	7	88424128	88424128	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:88424128C>A	uc003ujv.2	-	2	311	c.129G>T	c.(127-129)AAG>AAT	p.K43N	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	43											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			GAAGGAATTTCTTTAGGTGTA	0.398													32	187	---	---	---	---	PASS
TAS2R16	50833	broad.mit.edu	37	7	122635075	122635075	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:122635075T>C	uc003vkl.1	-	1	680	c.614A>G	c.(613-615)AAG>AGG	p.K205R		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	205	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						TTGTATCTGCTTGGTCAGTGA	0.458													27	89	---	---	---	---	PASS
SSPO	23145	broad.mit.edu	37	7	149502517	149502517	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr7:149502517C>T	uc010lpk.2	+	58	8330	c.8330C>T	c.(8329-8331)CCC>CTC	p.P2777L		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2777	TSP type-1 7.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCTGGACGCCCTGGACTTCC	0.662													8	37	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	3000083	3000083	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:3000083G>T	uc011kwk.1	-	41	6538	c.6148C>A	c.(6148-6150)CTC>ATC	p.L2050I	CSMD1_uc011kwj.1_Missense_Mutation_p.L1442I|CSMD1_uc010lrg.2_Missense_Mutation_p.L118I	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2050	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCGCGGGGAGATCCGTGCCG	0.458													8	80	---	---	---	---	PASS
RP1L1	94137	broad.mit.edu	37	8	10468360	10468360	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:10468360G>T	uc003wtc.2	-	4	3477	c.3248C>A	c.(3247-3249)ACG>AAG	p.T1083K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1083					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CATGATCTGCGTGGAGGCAGA	0.697													7	37	---	---	---	---	PASS
UNC5D	137970	broad.mit.edu	37	8	35648048	35648048	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:35648048C>T	uc003xjr.1	+	17	3157	c.2829C>T	c.(2827-2829)GCC>GCT	p.A943A	UNC5D_uc003xjs.1_Silent_p.A938A|UNC5D_uc003xju.1_Silent_p.A519A	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	943	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGATGAAGCCGACTTCAACT	0.493													8	61	---	---	---	---	PASS
CHRNA6	8973	broad.mit.edu	37	8	42611340	42611340	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:42611340C>A	uc003xpj.2	-	5	1048	c.1002G>T	c.(1000-1002)ACG>ACT	p.T334T	CHRNA6_uc011lcw.1_Silent_p.T319T	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	334	Cytoplasmic.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCATTGTGTGCGTGGTTGGGG	0.552													8	92	---	---	---	---	PASS
ARMC1	55156	broad.mit.edu	37	8	66525497	66525497	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:66525497T>C	uc003xvl.2	-	4	682	c.447A>G	c.(445-447)ATA>ATG	p.I149M	ARMC1_uc011leo.1_Intron	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	149					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			CAAGGCCATCTATATGCAAAA	0.378													37	98	---	---	---	---	PASS
PREX2	80243	broad.mit.edu	37	8	68939520	68939520	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:68939520C>A	uc003xxv.1	+	5	532	c.505C>A	c.(505-507)CCA>ACA	p.P169T	PREX2_uc003xxu.1_Missense_Mutation_p.P169T|PREX2_uc011lez.1_Missense_Mutation_p.P104T	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	169	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTTAGTAACACCAATACAAAG	0.348													4	127	---	---	---	---	PASS
HEY1	23462	broad.mit.edu	37	8	80677843	80677843	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:80677843C>A	uc003ybm.2	-	5	695	c.495G>T	c.(493-495)CGG>CGT	p.R165R	HEY1_uc010lzq.2_Silent_p.R46R|HEY1_uc003ybl.2_Silent_p.R169R	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	165					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			TCGCGGCTTCCCGCTGGGAAG	0.617											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	53	---	---	---	---	PASS
HEY1	23462	broad.mit.edu	37	8	80677875	80677875	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:80677875C>T	uc003ybm.2	-	5	663	c.463G>A	c.(463-465)GTT>ATT	p.V155I	HEY1_uc010lzq.2_Missense_Mutation_p.V36I|HEY1_uc003ybl.2_Missense_Mutation_p.V159I	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	155	Orange.				angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			AGATGCGAAACCAGTCGAACT	0.592											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	65	---	---	---	---	PASS
RIMS2	9699	broad.mit.edu	37	8	104922413	104922413	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:104922413C>A	uc003yls.2	+	3	1251	c.1010C>A	c.(1009-1011)GCA>GAA	p.A337E	RIMS2_uc003ylp.2_Missense_Mutation_p.A559E|RIMS2_uc003ylw.2_Missense_Mutation_p.A367E|RIMS2_uc003ylq.2_Missense_Mutation_p.A367E|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGCAGTGAGGCATCCCCAATG	0.388										HNSCC(12;0.0054)			28	101	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113563039	113563039	+	Silent	SNP	T	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:113563039T>A	uc003ynu.2	-	27	4584	c.4425A>T	c.(4423-4425)CCA>CCT	p.P1475P	CSMD3_uc003yns.2_Silent_p.P747P|CSMD3_uc003ynt.2_Silent_p.P1435P|CSMD3_uc011lhx.1_Silent_p.P1371P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1475	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTTTCTGGTGGACCGTCCC	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	84	---	---	---	---	PASS
TEK	7010	broad.mit.edu	37	9	27168569	27168569	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr9:27168569G>C	uc003zqi.3	+	3	883	c.441G>C	c.(439-441)TTG>TTC	p.L147F	TEK_uc010mjc.1_Intron|TEK_uc011lnn.1_Missense_Mutation_p.L147F|TEK_uc011lno.1_Missense_Mutation_p.L147F|TEK_uc011lnp.1_Missense_Mutation_p.L43F|TEK_uc003zqj.1_Missense_Mutation_p.L124F	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	147	Extracellular (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AAAAGGTATTGATTAAAGAAG	0.333													18	46	---	---	---	---	PASS
VPS13A	23230	broad.mit.edu	37	9	79917868	79917868	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr9:79917868G>T	uc004akr.2	+	34	4110	c.3850G>T	c.(3850-3852)GAT>TAT	p.D1284Y	VPS13A_uc004akp.3_Missense_Mutation_p.D1284Y|VPS13A_uc004akq.3_Missense_Mutation_p.D1284Y|VPS13A_uc004aks.2_Missense_Mutation_p.D1245Y|VPS13A_uc010mpo.1_5'UTR	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1284	TPR 4.				Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GGAAGTACTGGATCTACTCCT	0.338													34	108	---	---	---	---	PASS
ZCCHC6	79670	broad.mit.edu	37	9	88903620	88903620	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr9:88903620G>A	uc004aoq.2	-	27	4675	c.4460C>T	c.(4459-4461)TCA>TTA	p.S1487L	ZCCHC6_uc010mqe.2_Missense_Mutation_p.S387L|ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.S1251L|ZCCHC6_uc004aou.2_Missense_Mutation_p.S1487L	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1487					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						CCTCTTCGCTGAGGCTTTTCC	0.433													19	73	---	---	---	---	PASS
ASTN2	23245	broad.mit.edu	37	9	119976866	119976866	+	Silent	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr9:119976866G>C	uc004bjs.1	-	3	887	c.786C>G	c.(784-786)CCC>CCG	p.P262P	ASTN2_uc004bjr.1_Silent_p.P262P|ASTN2_uc004bjt.1_Silent_p.P262P	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	262	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CCCGCGCCTGGGGACCCAGCA	0.607													19	51	---	---	---	---	PASS
DCLRE1C	64421	broad.mit.edu	37	10	14995911	14995911	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:14995911G>C	uc001inn.2	-	1	184	c.99C>G	c.(97-99)CAC>CAG	p.H33Q	DCLRE1C_uc010qbx.1_Missense_Mutation_p.H33Q|DCLRE1C_uc001inl.2_5'UTR|DCLRE1C_uc009xji.2_5'UTR|DCLRE1C_uc001inm.2_5'UTR|DCLRE1C_uc001ino.2_5'UTR|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_5'UTR|DCLRE1C_uc001inq.2_5'UTR|DCLRE1C_uc001inr.2_5'UTR	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	33				H->A: Abolishes PRKDC-dependent endonuclease activity and V(D)J recombination.	DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						CTTTGTGGCAGTGGGACAGGA	0.647								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					13	53	---	---	---	---	PASS
VIM	7431	broad.mit.edu	37	10	17276803	17276803	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:17276803G>T	uc001iou.2	+	6	1407	c.994G>T	c.(994-996)GCC>TCC	p.A332S	VIM_uc001iov.1_Missense_Mutation_p.A332S|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.A332S|VIM_uc001ioy.1_Missense_Mutation_p.A332S|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Intron|VIM_uc001ipc.1_Missense_Mutation_p.A332S	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	332	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						TGAAGTGGATGCCCTTAAAGG	0.517													11	89	---	---	---	---	PASS
ANKRD26	22852	broad.mit.edu	37	10	27326951	27326951	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:27326951C>T	uc001ith.2	-	22	2577	c.2405G>A	c.(2404-2406)AGA>AAA	p.R802K	ANKRD26_uc001itg.2_Missense_Mutation_p.R489K|ANKRD26_uc009xku.1_Missense_Mutation_p.R803K	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	802	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						ATCAGCATTTCTTCTCTTCTC	0.303													4	57	---	---	---	---	PASS
PTCHD3	374308	broad.mit.edu	37	10	27687254	27687254	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:27687254G>T	uc001itu.2	-	4	2391	c.2273C>A	c.(2272-2274)TCC>TAC	p.S758Y		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	758					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TTTGGCTGAGGAAGAAACATC	0.318													13	42	---	---	---	---	PASS
ZEB1	6935	broad.mit.edu	37	10	31809110	31809110	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:31809110T>C	uc001ivs.3	+	7	910	c.847T>C	c.(847-849)TAT>CAT	p.Y283H	ZEB1_uc001ivr.3_Missense_Mutation_p.Y65H|ZEB1_uc010qee.1_Missense_Mutation_p.Y65H|ZEB1_uc010qef.1_Missense_Mutation_p.Y65H|ZEB1_uc009xlj.1_Missense_Mutation_p.Y209H|ZEB1_uc010qeg.1_Missense_Mutation_p.Y142H|ZEB1_uc009xlk.1_Missense_Mutation_p.Y65H|ZEB1_uc001ivt.3_Missense_Mutation_p.Y65H|ZEB1_uc001ivu.3_Missense_Mutation_p.Y284H|ZEB1_uc001ivv.3_Missense_Mutation_p.Y263H|ZEB1_uc010qeh.1_Missense_Mutation_p.Y216H|ZEB1_uc009xlo.1_Missense_Mutation_p.Y266H|ZEB1_uc009xlp.2_Missense_Mutation_p.Y267H	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	283	C2H2-type 4; atypical.				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TTCTGGCTCCTATAGCTCACA	0.398													7	53	---	---	---	---	PASS
ANKRD30A	91074	broad.mit.edu	37	10	37508496	37508496	+	Nonsense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:37508496A>T	uc001iza.1	+	34	3787	c.3688A>T	c.(3688-3690)AGA>TGA	p.R1230*		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1286	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ACATGCACAAAGAGACCAACG	0.373													7	39	---	---	---	---	PASS
SEC24C	9632	broad.mit.edu	37	10	75519790	75519790	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:75519790C>T	uc001juw.2	+	6	675	c.496C>T	c.(496-498)CTG>TTG	p.L166L	SEC24C_uc010qkn.1_RNA|SEC24C_uc009xrj.1_Silent_p.L24L|SEC24C_uc001jux.2_Silent_p.L166L|SEC24C_uc010qko.1_Silent_p.L24L|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	166					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					ACCAACATCGCTGGCTTCAGC	0.532													26	170	---	---	---	---	PASS
C10orf79	80217	broad.mit.edu	37	10	105905258	105905258	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:105905258T>C	uc001kxw.2	-	31	4036	c.3920A>G	c.(3919-3921)TAC>TGC	p.Y1307C	C10orf79_uc009xxq.2_Missense_Mutation_p.Y586C	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1307											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		AAAAAGTTTGTAGAGTATATC	0.363													5	36	---	---	---	---	PASS
CUZD1	50624	broad.mit.edu	37	10	124605305	124605305	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:124605305C>T	uc001lgq.2	-	1	387	c.55G>A	c.(55-57)GCG>ACG	p.A19T	CUZD1_uc009yaf.2_5'UTR|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.A19T|CUZD1_uc010qtz.1_Missense_Mutation_p.A19T	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	19					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GTCAGCTCCGCCAAACAGGAG	0.448													9	41	---	---	---	---	PASS
CUZD1	50624	broad.mit.edu	37	10	124605306	124605306	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:124605306C>T	uc001lgq.2	-	1	386	c.54G>A	c.(52-54)TTG>TTA	p.L18L	CUZD1_uc009yaf.2_5'UTR|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Silent_p.L18L|CUZD1_uc010qtz.1_Silent_p.L18L	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	18					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		TCAGCTCCGCCAAACAGGAGA	0.453													9	41	---	---	---	---	PASS
FAM196A	642938	broad.mit.edu	37	10	128973697	128973697	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr10:128973697C>T	uc001lju.1	-	1	1004	c.963G>A	c.(961-963)CAG>CAA	p.Q321Q	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Silent_p.Q321Q|FAM196A_uc001ljv.1_Silent_p.Q321Q|FAM196A_uc009yap.1_Silent_p.Q321Q	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	321										ovary(2)	2						TCTGCGACGGCTGCTCACTAC	0.642													21	88	---	---	---	---	PASS
OR51M1	390059	broad.mit.edu	37	11	5411216	5411216	+	Silent	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:5411216G>C	uc010qzc.1	+	1	588	c.588G>C	c.(586-588)GTG>GTC	p.V196V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	196						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCAGGAAGTGATACAGCTGG	0.517													5	148	---	---	---	---	PASS
SCUBE2	57758	broad.mit.edu	37	11	9051542	9051542	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:9051542G>A	uc001mhh.1	-	18	2385	c.2305C>T	c.(2305-2307)CGT>TGT	p.R769C	SCUBE2_uc001mhi.1_Missense_Mutation_p.R741C|SCUBE2_uc001mhj.1_Missense_Mutation_p.R643C	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	769						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ACTGGGCAACGAATACATCGG	0.403													34	47	---	---	---	---	PASS
NAV2	89797	broad.mit.edu	37	11	19955304	19955304	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:19955304C>T	uc010rdm.1	+	8	1944	c.1583C>T	c.(1582-1584)GCC>GTC	p.A528V	NAV2_uc001mpp.2_Missense_Mutation_p.A441V|NAV2_uc001mpr.3_Missense_Mutation_p.A505V	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	528	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						aaggaCCTTGCCAAGAGAGCC	0.388													24	27	---	---	---	---	PASS
CKAP5	9793	broad.mit.edu	37	11	46797843	46797843	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:46797843C>T	uc001ndi.1	-	24	3063	c.2953G>A	c.(2953-2955)GAA>AAA	p.E985K	CKAP5_uc009ylg.1_Missense_Mutation_p.E871K|CKAP5_uc001ndj.1_Missense_Mutation_p.E985K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	985					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TTGAGCTCTTCAGAAAGATCT	0.438													10	50	---	---	---	---	PASS
OR4B1	119765	broad.mit.edu	37	11	48238812	48238812	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:48238812T>G	uc010rhs.1	+	1	451	c.451T>G	c.(451-453)TTT>GTT	p.F151V		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						GCTGGGGGGCTTTTGTCACTC	0.453													26	60	---	---	---	---	PASS
LRRC55	219527	broad.mit.edu	37	11	56949576	56949576	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:56949576C>A	uc001njl.1	+	1	356	c.209C>A	c.(208-210)GCC>GAC	p.A70D		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	40						integral to membrane					0						CTCTTGGCAGCCGGGTTGATG	0.637													8	40	---	---	---	---	PASS
CTNND1	1500	broad.mit.edu	37	11	57569663	57569663	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:57569663T>G	uc001nmc.3	+	7	1986	c.1415T>G	c.(1414-1416)ATT>AGT	p.I472S	CTNND1_uc001nlh.1_Missense_Mutation_p.I472S|CTNND1_uc001nlu.3_Missense_Mutation_p.I371S|CTNND1_uc001nlt.3_Missense_Mutation_p.I371S|CTNND1_uc001nls.3_Missense_Mutation_p.I371S|CTNND1_uc001nlw.3_Missense_Mutation_p.I371S|CTNND1_uc001nmf.3_Missense_Mutation_p.I472S|CTNND1_uc001nmd.3_Missense_Mutation_p.I418S|CTNND1_uc001nlk.3_Missense_Mutation_p.I418S|CTNND1_uc001nme.3_Missense_Mutation_p.I472S|CTNND1_uc001nll.3_Missense_Mutation_p.I418S|CTNND1_uc001nmg.3_Missense_Mutation_p.I418S|CTNND1_uc001nlj.3_Missense_Mutation_p.I418S|CTNND1_uc001nlr.3_Missense_Mutation_p.I418S|CTNND1_uc001nlp.3_Missense_Mutation_p.I418S|CTNND1_uc001nlx.3_Missense_Mutation_p.I149S|CTNND1_uc001nlz.3_Missense_Mutation_p.I149S|CTNND1_uc009ymn.2_Missense_Mutation_p.I149S|CTNND1_uc001nlm.3_Missense_Mutation_p.I472S|CTNND1_uc001nly.3_Missense_Mutation_p.I149S|CTNND1_uc001nmb.3_Missense_Mutation_p.I149S|CTNND1_uc001nma.3_Missense_Mutation_p.I149S|CTNND1_uc001nmi.3_Missense_Mutation_p.I371S|CTNND1_uc001nmh.3_Missense_Mutation_p.I472S|CTNND1_uc001nlq.3_Missense_Mutation_p.I371S|CTNND1_uc001nln.3_Missense_Mutation_p.I472S|CTNND1_uc001nli.3_Missense_Mutation_p.I472S|CTNND1_uc001nlo.3_Missense_Mutation_p.I371S|CTNND1_uc001nlv.3_Missense_Mutation_p.I371S	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	472	ARM 3.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				ACTGAAGTTATTACCGGTGAG	0.428													68	189	---	---	---	---	PASS
MS4A6A	64231	broad.mit.edu	37	11	59943081	59943081	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:59943081G>A	uc001nor.2	-	5	581	c.343C>T	c.(343-345)CAT>TAT	p.H115Y	MS4A6A_uc001noq.2_Missense_Mutation_p.H115Y|MS4A6A_uc001nos.3_Missense_Mutation_p.H143Y|MS4A6A_uc009ymv.2_Missense_Mutation_p.H115Y|MS4A6A_uc001not.2_Missense_Mutation_p.H115Y|MS4A6A_uc010rla.1_Missense_Mutation_p.H143Y|MS4A6A_uc010rlb.1_Missense_Mutation_p.H70Y	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	115	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AGGCTGCTATGCACCTGAAAG	0.443													11	53	---	---	---	---	PASS
MS4A14	84689	broad.mit.edu	37	11	60182994	60182994	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:60182994C>A	uc001npj.2	+	5	1118	c.553C>A	c.(553-555)CAA>AAA	p.Q185K	MS4A14_uc001npi.2_Missense_Mutation_p.Q73K|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.Q168K|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	185						integral to membrane	receptor activity			breast(1)	1						ATTTGTGCTTCAAGAAGAGTT	0.368													12	108	---	---	---	---	PASS
SYT7	9066	broad.mit.edu	37	11	61290739	61290739	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:61290739G>T	uc001nrv.2	-	8	921	c.915C>A	c.(913-915)TAC>TAA	p.Y305*	SYT7_uc009ynr.2_Nonsense_Mutation_p.Y380*	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	305	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						ATACCTTCACGTAGGGGTCTA	0.557													11	75	---	---	---	---	PASS
SLC22A12	116085	broad.mit.edu	37	11	64368969	64368969	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:64368969G>C	uc001oam.1	+	10	2355	c.1608G>C	c.(1606-1608)AAG>AAC	p.K536N	SLC22A12_uc001oal.1_Missense_Mutation_p.K315N|SLC22A12_uc009yps.1_Missense_Mutation_p.K502N|SLC22A12_uc001oan.1_Missense_Mutation_p.K428N	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	536					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GGGCAGTAAAGAAGGCAACAC	0.572													4	41	---	---	---	---	PASS
NRXN2	9379	broad.mit.edu	37	11	64374839	64374839	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:64374839G>A	uc001oap.2	-	8	2341	c.1830C>T	c.(1828-1830)GCC>GCT	p.A610A	NRXN2_uc001oar.2_Silent_p.A1656A|NRXN2_uc001oas.2_Silent_p.A1586A|NRXN2_uc001oao.2_Silent_p.A296A|NRXN2_uc001oaq.2_Silent_p.A1323A	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	610	Helical; (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						ACTTATACATGGCGTAGAGGA	0.617													7	56	---	---	---	---	PASS
NADSYN1	55191	broad.mit.edu	37	11	71193945	71193945	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:71193945A>G	uc001oqn.2	+	14	1327	c.1201A>G	c.(1201-1203)ACC>GCC	p.T401A	NADSYN1_uc001oqo.2_Missense_Mutation_p.T141A|NADSYN1_uc001oqp.2_Missense_Mutation_p.T30A	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	401	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GATCAGCTACACCCCCCAGGA	0.577													10	58	---	---	---	---	PASS
NUMA1	4926	broad.mit.edu	37	11	71719783	71719783	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:71719783C>G	uc001orl.1	-	20	5339	c.5167G>C	c.(5167-5169)GAC>CAC	p.D1723H	NUMA1_uc001orj.2_5'UTR|NUMA1_uc009ysw.1_Missense_Mutation_p.D1272H|NUMA1_uc001ork.1_Missense_Mutation_p.D587H|NUMA1_uc001orm.1_Missense_Mutation_p.D1709H|NUMA1_uc001orn.2_Missense_Mutation_p.D1286H	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1723					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						TCCAGGCTGTCAATACTCAAG	0.562			T	RARA	APL								21	88	---	---	---	---	PASS
ODZ4	26011	broad.mit.edu	37	11	78467899	78467899	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:78467899C>A	uc001ozl.3	-	19	3170	c.2707G>T	c.(2707-2709)GGC>TGC	p.G903C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	903	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTGTCCCTGCCCACGAGGAAC	0.592													6	34	---	---	---	---	PASS
TYR	7299	broad.mit.edu	37	11	88911308	88911308	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:88911308G>A	uc001pcs.2	+	1	269	c.187G>A	c.(187-189)GCA>ACA	p.A63T		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	63	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TCTGTCCAATGCACCACTTGG	0.552									Oculocutaneous_Albinism				5	39	---	---	---	---	PASS
ARHGAP20	57569	broad.mit.edu	37	11	110450560	110450560	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr11:110450560C>A	uc001pkz.1	-	16	3395	c.3110G>T	c.(3109-3111)TGG>TTG	p.W1037L	ARHGAP20_uc001pky.1_Missense_Mutation_p.W1014L|ARHGAP20_uc009yyb.1_Missense_Mutation_p.W1001L|ARHGAP20_uc001pla.1_Missense_Mutation_p.W1001L|ARHGAP20_uc001plb.2_Missense_Mutation_p.W580L	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1037					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ATTTCTCAACCATGTGCTGGG	0.493													18	138	---	---	---	---	PASS
KCNA5	3741	broad.mit.edu	37	12	5154720	5154720	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:5154720C>A	uc001qni.2	+	1	1636	c.1407C>A	c.(1405-1407)GAC>GAA	p.D469E		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	469						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GCATCCCTGACGCCTTCTGGT	0.582													16	120	---	---	---	---	PASS
NTF3	4908	broad.mit.edu	37	12	5603793	5603793	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:5603793G>A	uc001qnl.3	+	1	496	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	NTF3_uc001qnk.3_Missense_Mutation_p.R151Q	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	138					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						CGGCGGAAACGGTACGCGGAG	0.602													6	180	---	---	---	---	PASS
A2M	2	broad.mit.edu	37	12	9251320	9251320	+	Silent	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:9251320G>C	uc001qvk.1	-	15	1847	c.1734C>G	c.(1732-1734)CTC>CTG	p.L578L	A2M_uc009zgk.1_Silent_p.L428L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	578					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GTGAGGCTGGGAGACTTTGTG	0.537													7	10	---	---	---	---	PASS
LRRK2	120892	broad.mit.edu	37	12	40681168	40681168	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:40681168T>C	uc001rmg.3	+	20	2637	c.2516T>C	c.(2515-2517)CTA>CCA	p.L839P	LRRK2_uc001rmh.1_Missense_Mutation_p.L461P	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	839					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GCATCTACACTAGCAAGAATG	0.358													8	66	---	---	---	---	PASS
PRICKLE1	144165	broad.mit.edu	37	12	42858718	42858718	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:42858718C>A	uc010skv.1	-	7	1405	c.1118G>T	c.(1117-1119)CGA>CTA	p.R373L	PRICKLE1_uc001rnl.2_Missense_Mutation_p.R373L|PRICKLE1_uc010skw.1_Missense_Mutation_p.R373L|PRICKLE1_uc001rnm.2_Missense_Mutation_p.R373L	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	373					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		ATCCAATTTTCGAGAAAGGGT	0.478													10	58	---	---	---	---	PASS
COL2A1	1280	broad.mit.edu	37	12	48387245	48387245	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:48387245G>A	uc001rqu.2	-	15	1146	c.965C>T	c.(964-966)CCA>CTA	p.P322L	COL2A1_uc001rqv.2_Missense_Mutation_p.P253L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	322	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ACTTACCATTGGGCCCGGAGA	0.512													16	62	---	---	---	---	PASS
SILV	6490	broad.mit.edu	37	12	56355204	56355204	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:56355204C>T	uc001sip.2	-	3	262	c.231G>A	c.(229-231)CTG>CTA	p.L77L	SILV_uc001siq.2_Silent_p.L77L|SILV_uc010spx.1_Intron|SILV_uc001sir.2_Silent_p.L77L	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	77					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						TTGCACCAATCAGTGTAGGCC	0.498													12	79	---	---	---	---	PASS
LEMD3	23592	broad.mit.edu	37	12	65564642	65564642	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:65564642C>T	uc001ssl.1	+	1	1272	c.1266C>T	c.(1264-1266)CTC>CTT	p.L422L	LEMD3_uc009zqo.1_Silent_p.L422L	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	422					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		CTAGTTCACTCAGGATCAATC	0.517													31	111	---	---	---	---	PASS
SOCS2	8835	broad.mit.edu	37	12	93968892	93968892	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:93968892C>T	uc001tcw.1	+	3	1124	c.534C>T	c.(532-534)ATC>ATT	p.I178I	SOCS2_uc001tcx.1_Silent_p.I178I|SOCS2_uc009zsu.2_3'UTR|SOCS2_uc001tcy.1_Silent_p.I178I|SOCS2_uc001tcz.2_3'UTR	NM_003877	NP_003868	O14508	SOCS2_HUMAN	suppressor of cytokine signaling-2	178	SOCS box.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			lung(1)	1						CCGGTGCCATCTGGGGACTGC	0.413													21	87	---	---	---	---	PASS
TCTN1	79600	broad.mit.edu	37	12	111079360	111079360	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr12:111079360C>T	uc009zvs.2	+	10	1226	c.1118C>T	c.(1117-1119)CCA>CTA	p.P373L	TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Missense_Mutation_p.P313L|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Missense_Mutation_p.P359L|TCTN1_uc001trn.3_Missense_Mutation_p.P373L|TCTN1_uc001trj.1_Missense_Mutation_p.P317L|TCTN1_uc001trk.3_Intron|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	373					multicellular organismal development	extracellular region					0						AATACCCAGCCAGTCCCTCTC	0.423													24	102	---	---	---	---	PASS
ALG5	29880	broad.mit.edu	37	13	37573414	37573414	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr13:37573414C>T	uc001uvy.2	-	1	91	c.24G>A	c.(22-24)CTG>CTA	p.L8L	ALG5_uc010teq.1_Silent_p.L8L|ALG5_uc010ter.1_RNA|EXOSC8_uc001uvz.2_5'Flank|EXOSC8_uc001uwb.2_5'Flank|EXOSC8_uc001uwa.2_5'Flank|EXOSC8_uc001uwc.2_5'Flank	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	8	Helical; Signal-anchor for type II membrane protein; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		CGAGCACCGCCAGCTGCAACA	0.602													16	20	---	---	---	---	PASS
RB1	5925	broad.mit.edu	37	13	48881542	48881542	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr13:48881542G>T	uc001vcb.2	+	2	430	c.264G>T	c.(262-264)TTG>TTT	p.L88F	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	88					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(13)|p.?(3)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGGAGTATTGGTAAGGATTT	0.224		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			61	84	---	---	---	---	PASS
OR4K5	79317	broad.mit.edu	37	14	20389096	20389096	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr14:20389096G>T	uc010tkw.1	+	1	331	c.331G>T	c.(331-333)GAG>TAG	p.E111*		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TACTGGAGGGGAGATGGTGCT	0.433													47	580	---	---	---	---	PASS
IPO4	79711	broad.mit.edu	37	14	24652691	24652691	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr14:24652691C>A	uc001wmv.1	-	21	2223	c.2092G>T	c.(2092-2094)GTC>TTC	p.V698F	IPO4_uc001wmt.1_Missense_Mutation_p.V176F|IPO4_uc001wmu.2_Missense_Mutation_p.V360F|IPO4_uc001wmx.1_Missense_Mutation_p.V562F|IPO4_uc001wmy.1_Missense_Mutation_p.V562F|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.V698F	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	698					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TCTTCAAAGACACTTTCCATG	0.587													3	55	---	---	---	---	PASS
KLHDC2	23588	broad.mit.edu	37	14	50246318	50246318	+	Silent	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr14:50246318A>G	uc001wwx.2	+	7	1039	c.639A>G	c.(637-639)AAA>AAG	p.K213K	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Silent_p.K213K|KLHDC2_uc010anp.2_Silent_p.K213K	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	213						nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					AATAGGGTAAAGCACCTTCAC	0.418													17	22	---	---	---	---	PASS
HERC2	8924	broad.mit.edu	37	15	28456229	28456229	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr15:28456229G>A	uc001zbj.2	-	44	7094	c.6988C>T	c.(6988-6990)CGG>TGG	p.R2330W		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2330					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCAGCGCCCGACCTGCTTTC	0.547													5	130	---	---	---	---	PASS
ANPEP	290	broad.mit.edu	37	15	90340950	90340950	+	Silent	SNP	G	C	C	rs150492701	byFrequency	TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr15:90340950G>C	uc002bop.3	-	15	2305	c.2013C>G	c.(2011-2013)GCC>GCG	p.A671A		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	671	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GGACCTTATGGGCACTGGGAA	0.597													5	123	---	---	---	---	PASS
CD19	930	broad.mit.edu	37	16	28944428	28944428	+	Silent	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr16:28944428C>A	uc002drs.2	+	3	614	c.552C>A	c.(550-552)CTC>CTA	p.L184L	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.L184L	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	184	Extracellular (Potential).|Ig-like C2-type 2.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						ACCAGAGCCTCAGCCAGGGTA	0.607													11	56	---	---	---	---	PASS
CD19	930	broad.mit.edu	37	16	28944429	28944429	+	Missense_Mutation	SNP	A	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr16:28944429A>C	uc002drs.2	+	3	615	c.553A>C	c.(553-555)AGC>CGC	p.S185R	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.S185R	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	185	Extracellular (Potential).|Ig-like C2-type 2.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						CCAGAGCCTCAGCCAGGGTAT	0.612													12	55	---	---	---	---	PASS
CLEC18B	497190	broad.mit.edu	37	16	74443468	74443468	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr16:74443468T>G	uc002fct.2	-	12	1510	c.1310A>C	c.(1309-1311)AAC>ACC	p.N437T	CLEC18B_uc002fcu.2_Missense_Mutation_p.N428T	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	437	C-type lectin.					extracellular region	sugar binding				0						GATGTAACGGTTTCGGGTTTT	0.602													4	104	---	---	---	---	PASS
CLEC18B	497190	broad.mit.edu	37	16	74443487	74443487	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr16:74443487G>C	uc002fct.2	-	12	1491	c.1291C>G	c.(1291-1293)CAG>GAG	p.Q431E	CLEC18B_uc002fcu.2_Missense_Mutation_p.Q422E	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	431	C-type lectin.					extracellular region	sugar binding				0						TTGCAGCGCTGGTCGTTCCAG	0.592													5	115	---	---	---	---	PASS
BCAR1	9564	broad.mit.edu	37	16	75263782	75263782	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr16:75263782T>C	uc002fdv.2	-	7	2363	c.2240A>G	c.(2239-2241)TAC>TGC	p.Y747C	BCAR1_uc002fdt.2_Missense_Mutation_p.Y200C|BCAR1_uc002fdu.2_Missense_Mutation_p.Y537C|BCAR1_uc010cgu.2_Missense_Mutation_p.Y736C|BCAR1_uc010vna.1_Missense_Mutation_p.Y745C|BCAR1_uc010vnb.1_Missense_Mutation_p.Y793C|BCAR1_uc002fdw.2_Missense_Mutation_p.Y747C|BCAR1_uc010vnc.1_Missense_Mutation_p.Y599C|BCAR1_uc010vnd.1_Missense_Mutation_p.Y765C|BCAR1_uc002fdx.2_Missense_Mutation_p.Y765C	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	747	Divergent helix-loop-helix motif.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGCTCCAGGTAGAAGAGCAG	0.672													13	64	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7578507	7578507	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:7578507G>C	uc002gim.2	-	5	617	c.423C>G	c.(421-423)TGC>TGG	p.C141W	TP53_uc002gig.1_Missense_Mutation_p.C141W|TP53_uc002gih.2_Missense_Mutation_p.C141W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C9W|TP53_uc010cng.1_Missense_Mutation_p.C9W|TP53_uc002gii.1_Missense_Mutation_p.C9W|TP53_uc010cnh.1_Missense_Mutation_p.C141W|TP53_uc010cni.1_Missense_Mutation_p.C141W|TP53_uc002gij.2_Missense_Mutation_p.C141W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C48W|TP53_uc002gio.2_Missense_Mutation_p.C9W|TP53_uc010vug.1_Missense_Mutation_p.C102W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	141	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> A (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(61)|p.C141*(11)|p.C141R(10)|p.C141W(10)|p.0?(7)|p.C141C(4)|p.C141F(4)|p.C141fs*29(3)|p.N131fs*27(2)|p.C141S(2)|p.C141fs*8(2)|p.L137_W146del10(1)|p.K139fs*4(1)|p.C141fs*34(1)|p.C141fs*30(1)|p.A138_V143delAKTCPV(1)|p.A138_P142delAKTCP(1)|p.C141A(1)|p.C141G(1)|p.C141_P142insXX(1)|p.K139_C141>N(1)|p.C141fs*5(1)|p.P142del(1)|p.P142fs*7(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGCACAGGGCAGGTCTTGG	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	34	---	---	---	---	PASS
CHD3	1107	broad.mit.edu	37	17	7793959	7793959	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:7793959A>G	uc002gje.2	+	3	434	c.284A>G	c.(283-285)TAT>TGT	p.Y95C	CHD3_uc002gjd.2_Missense_Mutation_p.Y154C|CHD3_uc002gjf.2_Missense_Mutation_p.Y95C|CHD3_uc002gjg.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	95					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGCAGTGAATATGGAACCGGA	0.478													4	21	---	---	---	---	PASS
MYH2	4620	broad.mit.edu	37	17	10429113	10429113	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:10429113G>T	uc010coi.2	-	31	4396	c.4268C>A	c.(4267-4269)ACG>AAG	p.T1423K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.T1423K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1423	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCGCTGCTTCGTCTTTTCGAG	0.512													29	39	---	---	---	---	PASS
CLTC	1213	broad.mit.edu	37	17	57733276	57733276	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:57733276A>T	uc002ixq.1	+	6	1300	c.857A>T	c.(856-858)GAT>GTT	p.D286V	CLTC_uc002ixp.2_Missense_Mutation_p.D286V|CLTC_uc002ixr.1_Missense_Mutation_p.D290V	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	286	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CACCTCTATGATCTTGAGACT	0.358			T	ALK|TFE3	ALCL|renal 								28	132	---	---	---	---	PASS
ABCA10	10349	broad.mit.edu	37	17	67215713	67215713	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:67215713A>T	uc010dfa.1	-	7	1382	c.503T>A	c.(502-504)GTG>GAG	p.V168E	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_Missense_Mutation_p.V60E	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	168					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAGACCCATCACTGTCATCAG	0.308													46	63	---	---	---	---	PASS
ICT1	3396	broad.mit.edu	37	17	73008861	73008861	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:73008861G>A	uc002jmm.2	+	1	82	c.80G>A	c.(79-81)CGC>CAC	p.R27H		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	27					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					CGGTGCCCACGCCGGGCGCTG	0.667											OREG0024724	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12	---	---	---	---	PASS
NOTUM	147111	broad.mit.edu	37	17	79914879	79914879	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr17:79914879G>T	uc010wvg.1	-	7	1039	c.767C>A	c.(766-768)GCC>GAC	p.A256D		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	256						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CACCTGGATGGCTGGGTAGCC	0.667													20	17	---	---	---	---	PASS
TCEB3B	51224	broad.mit.edu	37	18	44559910	44559910	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr18:44559910C>T	uc002lcr.1	-	1	2079	c.1726G>A	c.(1726-1728)GCA>ACA	p.A576T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	576	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CTAACGAGTGCGTGATTGTCT	0.512													36	68	---	---	---	---	PASS
ZCCHC2	54877	broad.mit.edu	37	18	60223462	60223462	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr18:60223462C>G	uc002lip.3	+	6	1340	c.1340C>G	c.(1339-1341)GCT>GGT	p.A447G	ZCCHC2_uc002lio.2_RNA	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	447					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCATCACAAGCTTTTCTACAA	0.363													6	21	---	---	---	---	PASS
NFATC1	4772	broad.mit.edu	37	18	77193660	77193660	+	Silent	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr18:77193660C>G	uc010xfg.1	+	3	1761	c.1308C>G	c.(1306-1308)TCC>TCG	p.S436S	NFATC1_uc002lnc.1_Silent_p.S436S|NFATC1_uc010xff.1_Silent_p.S436S|NFATC1_uc002lnd.2_Silent_p.S436S|NFATC1_uc002lne.2_5'UTR|NFATC1_uc010xfh.1_Silent_p.S436S|NFATC1_uc010xfi.1_Silent_p.S423S|NFATC1_uc010xfj.1_5'UTR|NFATC1_uc002lnf.2_Silent_p.S423S|NFATC1_uc002lng.2_Silent_p.S423S|NFATC1_uc010xfk.1_Silent_p.S423S	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	436	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		AGCCCAAGTCCCACCACCGAG	0.692													40	88	---	---	---	---	PASS
ABCA7	10347	broad.mit.edu	37	19	1051539	1051539	+	Silent	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:1051539T>C	uc002lqw.3	+	21	3147	c.2916T>C	c.(2914-2916)CCT>CCC	p.P972P	ABCA7_uc010dsb.1_Silent_p.P834P	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	972	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGTGGATCCTGCTTCCCGCC	0.473													8	29	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9063785	9063785	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:9063785G>A	uc002mkp.2	-	3	23865	c.23661C>T	c.(23659-23661)ACC>ACT	p.T7887T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7889	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACCAGCTGACGGTTCTTGTGG	0.502													34	86	---	---	---	---	PASS
FARSA	2193	broad.mit.edu	37	19	13035919	13035919	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:13035919C>T	uc002mvs.2	-	8	959	c.911G>A	c.(910-912)GGC>GAC	p.G304D	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Missense_Mutation_p.G273D|FARSA_uc010dyy.1_Missense_Mutation_p.G225D	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	304					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	TGAGCCGTAGCCGCCCTGAGA	0.622													6	14	---	---	---	---	PASS
EMR3	84658	broad.mit.edu	37	19	14765947	14765947	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:14765947G>A	uc002mzi.3	-	6	572	c.424C>T	c.(424-426)CTT>TTT	p.L142F	EMR3_uc010dzp.2_Missense_Mutation_p.L90F|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	142	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						TTGGTGAGAAGTGACTCAAAT	0.368													16	144	---	---	---	---	PASS
B3GNT3	10331	broad.mit.edu	37	19	17922703	17922703	+	Silent	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:17922703T>C	uc002nhk.1	+	3	976	c.891T>C	c.(889-891)GAT>GAC	p.D297D	B3GNT3_uc002nhl.1_Silent_p.D297D|B3GNT3_uc010ebd.1_Silent_p.D297D|B3GNT3_uc010ebe.1_Silent_p.D297D	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	297	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CCATTGATGATGTCTTCCTGG	0.627													74	194	---	---	---	---	PASS
JUND	3727	broad.mit.edu	37	19	18391543	18391543	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:18391543C>T	uc002nip.2	-	1	890	c.752G>A	c.(751-753)AGC>AAC	p.S251N	hsa-mir-3188|MI0014232_5'Flank	NM_005354	NP_005345	P17535	JUND_HUMAN	jun D proto-oncogene	251					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						CTCGCCGAAGCTCGGCACGTC	0.726													14	27	---	---	---	---	PASS
GDF15	9518	broad.mit.edu	37	19	18499285	18499285	+	Missense_Mutation	SNP	A	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:18499285A>C	uc002niv.2	+	2	499	c.467A>C	c.(466-468)CAC>CCC	p.H156P		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	156					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						CCCGCGCTGCACCTGCGACTG	0.701											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	11	---	---	---	---	PASS
ZNF99	7652	broad.mit.edu	37	19	22941130	22941130	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:22941130A>T	uc010xrh.1	-	5	1308	c.1308T>A	c.(1306-1308)CAT>CAA	p.H436Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GAATTATCTTATGTTTTCTAA	0.333													24	68	---	---	---	---	PASS
ZNF585B	92285	broad.mit.edu	37	19	37677356	37677356	+	Silent	SNP	C	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:37677356C>T	uc002ofq.2	-	5	1337	c.1083G>A	c.(1081-1083)AAG>AAA	p.K361K	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Silent_p.K175K	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGTAAAGGCCTTCCCACACT	0.418													9	156	---	---	---	---	PASS
DHDH	27294	broad.mit.edu	37	19	49442786	49442786	+	Silent	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:49442786G>T	uc002ple.1	+	4	487	c.447G>T	c.(445-447)GTG>GTT	p.V149V		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	149					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		ACCTCCGGGTGGCTCGGGCAG	0.627													25	100	---	---	---	---	PASS
LILRA3	11026	broad.mit.edu	37	19	54803248	54803248	+	Silent	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:54803248G>A	uc002qfd.2	-	4	494	c.429C>T	c.(427-429)ATC>ATT	p.I143I	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.I143I	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	143	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGTCACACTGGATGGTCACAT	0.542													31	57	---	---	---	---	PASS
NLRP7	199713	broad.mit.edu	37	19	55450740	55450740	+	Nonsense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr19:55450740C>A	uc002qih.3	-	4	1523	c.1447G>T	c.(1447-1449)GAG>TAG	p.E483*	NLRP7_uc002qig.3_Nonsense_Mutation_p.E483*|NLRP7_uc002qii.3_Nonsense_Mutation_p.E483*|NLRP7_uc010esk.2_Nonsense_Mutation_p.E483*|NLRP7_uc010esl.2_Nonsense_Mutation_p.E511*	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	483	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCCTCCTTCTCCAGGGCGTAG	0.592													13	64	---	---	---	---	PASS
SEC23B	10483	broad.mit.edu	37	20	18529263	18529263	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:18529263A>T	uc002wqz.1	+	16	2197	c.1754A>T	c.(1753-1755)CAT>CTT	p.H585L	SEC23B_uc002wra.1_Missense_Mutation_p.H585L|SEC23B_uc002wrb.1_Missense_Mutation_p.H585L|SEC23B_uc010zsb.1_Missense_Mutation_p.H567L|SEC23B_uc002wrc.1_Missense_Mutation_p.H585L	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	585					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TTTATGTTCCATCTGAGAAGA	0.423													20	79	---	---	---	---	PASS
KIAA1755	85449	broad.mit.edu	37	20	36841984	36841984	+	Silent	SNP	C	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:36841984C>G	uc002xhy.1	-	14	3335	c.3063G>C	c.(3061-3063)GTG>GTC	p.V1021V	KIAA1755_uc002xhv.1_Silent_p.V85V|KIAA1755_uc002xhw.1_Silent_p.V76V|KIAA1755_uc002xhx.1_Silent_p.V299V	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	1021										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TCAGGGAGGCCACCTGCAGCC	0.672													9	25	---	---	---	---	PASS
DDX27	55661	broad.mit.edu	37	20	47838119	47838119	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:47838119G>A	uc002xuh.2	+	2	378	c.317G>A	c.(316-318)AGC>AAC	p.S106N		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	106	Asp/Glu/Lys-rich.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GATGTCATGAGCCAACTCAAG	0.522													17	43	---	---	---	---	PASS
ZFP64	55734	broad.mit.edu	37	20	50701752	50701752	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:50701752C>A	uc002xwk.2	-	9	1631	c.1282G>T	c.(1282-1284)GAC>TAC	p.D428Y	ZFP64_uc002xwj.2_Missense_Mutation_p.D209Y	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTTTTCAAGTCCGAGCTGATT	0.522													11	27	---	---	---	---	PASS
SAMSN1	64092	broad.mit.edu	37	21	15882692	15882692	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr21:15882692C>A	uc002yju.1	-	5	582	c.500G>T	c.(499-501)CGT>CTT	p.R167L	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Missense_Mutation_p.R235L	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	167	SH3.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CACTCTGGCACGGCCACAGAA	0.502													27	77	---	---	---	---	PASS
MGAT3	4248	broad.mit.edu	37	22	39884019	39884019	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr22:39884019G>T	uc003axv.3	+	2	906	c.667G>T	c.(667-669)GTG>TTG	p.V223L	MGAT3_uc010gxy.2_Missense_Mutation_p.V223L	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	223	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					CCTGCTGGACGTGCGCTTCCA	0.647													16	21	---	---	---	---	PASS
FRMPD4	9758	broad.mit.edu	37	X	12734276	12734276	+	Silent	SNP	A	G	G			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chrX:12734276A>G	uc004cuz.1	+	15	2204	c.1698A>G	c.(1696-1698)CAA>CAG	p.Q566Q	FRMPD4_uc011mij.1_Silent_p.Q558Q	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	566					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AAGGGGAACAAGAAGCCCAGA	0.463													27	58	---	---	---	---	PASS
KLHL4	56062	broad.mit.edu	37	X	86919919	86919919	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chrX:86919919G>T	uc004efb.2	+	10	2263	c.2081G>T	c.(2080-2082)AGA>ATA	p.R694I	KLHL4_uc004efa.2_Missense_Mutation_p.R694I	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	694	Kelch 6.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GATGCACAGAGAAATGAATGG	0.318													19	26	---	---	---	---	PASS
XPNPEP2	7512	broad.mit.edu	37	X	128885770	128885770	+	Silent	SNP	T	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chrX:128885770T>C	uc004eut.1	+	9	1033	c.789T>C	c.(787-789)TAT>TAC	p.Y263Y		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	263					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CCTTCTTCTATTCCTACACGC	0.478													24	162	---	---	---	---	PASS
MAP7D3	79649	broad.mit.edu	37	X	135303015	135303015	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chrX:135303015G>T	uc004ezt.2	-	16	2486	c.2395C>A	c.(2395-2397)CGT>AGT	p.R799S	MAP7D3_uc004ezs.2_Missense_Mutation_p.R763S|MAP7D3_uc011mwc.1_Missense_Mutation_p.R781S|MAP7D3_uc010nsa.1_Missense_Mutation_p.R757S	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	799						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					GGCTCTTTACGGACCTGGCTG	0.388													99	116	---	---	---	---	PASS
F9	2158	broad.mit.edu	37	X	138619203	138619203	+	Silent	SNP	G	C	C			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chrX:138619203G>C	uc004fas.1	+	2	152	c.123G>C	c.(121-123)CTG>CTC	p.L41L	F9_uc004fat.1_Silent_p.L41L	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	41					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ACAAAATTCTGAATCGGCCAA	0.313													11	128	---	---	---	---	PASS
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	-	-			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr8:144511954_144511956delTGG	uc003yyc.1	-	1	621_623	c.621_623delCCA	c.(619-624)CACCAT>CAT	p.207_208HH>H		NM_201589	NP_963883	Q8NHW3	MAFA_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	207_208	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.581										HNSCC(29;0.082)			5	3	---	---	---	---	
PLA2G4E	123745	broad.mit.edu	37	15	42302338	42302338	+	Frame_Shift_Del	DEL	A	-	-	rs28736629		TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr15:42302338delA	uc001zow.1	-	1	108	c.108delT	c.(106-108)GGTfs	p.G36fs		NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	Error:Variant_position_missing_in_Q3MJ16_after_alignment					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		TGGCCCCCCCACCCCGGGCCT	0.592													18	14	---	---	---	---	
C20orf26	26074	broad.mit.edu	37	20	20257983	20257983	+	Frame_Shift_Del	DEL	G	-	-			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:20257983delG	uc002wru.2	+	22	2753	c.2677delG	c.(2677-2679)GCCfs	p.A893fs	C20orf26_uc010zse.1_Frame_Shift_Del_p.A873fs|C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	893										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GCTAGGAGCCGCCGGAGTCAC	0.667													86	51	---	---	---	---	
SNTA1	6640	broad.mit.edu	37	20	32005618	32005618	+	Frame_Shift_Del	DEL	C	-	-			TCGA-39-5021-01A-01D-1441-08	TCGA-39-5021-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8b4c6f-e6eb-4799-b64d-119afc691e3d	473e6ff7-6808-48ce-b586-05a46ea9f72e	g.chr20:32005618delC	uc002wzd.1	-	3	880	c.608delG	c.(607-609)GGCfs	p.G203fs	SNTA1_uc010zuf.1_Frame_Shift_Del_p.G203fs	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	203	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GGGTGTGGGGCCAGGGGAGGA	0.602													91	55	---	---	---	---