Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
PRAMEF2	65122	broad.mit.edu	37	1	12921409	12921409	+	Silent	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:12921409C>T	uc001aum.1	+	4	1287	c.1200C>T	c.(1198-1200)CAC>CAT	p.H400H		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	400											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGCGCCACACCAGTGGGC	0.557													22	58	---	---	---	---	PASS
SFRS11	9295	broad.mit.edu	37	1	70703197	70703197	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:70703197G>C	uc001des.2	+	7	804	c.680G>C	c.(679-681)CGA>CCA	p.R227P	SFRS11_uc001det.2_Missense_Mutation_p.R227P|SFRS11_uc001deu.2_Missense_Mutation_p.R227P|SFRS11_uc001dev.2_Missense_Mutation_p.R37P|SFRS11_uc001dew.2_Missense_Mutation_p.R167P	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	227					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						AAAAGAGTACGAGAAGCACAG	0.368													12	34	---	---	---	---	PASS
CLCA1	1179	broad.mit.edu	37	1	86961341	86961341	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:86961341C>A	uc001dlt.2	+	12	2225	c.2096C>A	c.(2095-2097)CCT>CAT	p.P699H		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	699					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CTGTACATACCTGGCTGGATT	0.433													8	15	---	---	---	---	PASS
S1PR1	1901	broad.mit.edu	37	1	101705192	101705192	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:101705192G>T	uc001dud.2	+	2	1166	c.652G>T	c.(652-654)GTC>TTC	p.V218F	S1PR1_uc009weg.2_Missense_Mutation_p.V218F	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	218	Helical; Name=5; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCTCTCCATCGTCATTCTGTA	0.567													27	60	---	---	---	---	PASS
RPTN	126638	broad.mit.edu	37	1	152127903	152127903	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:152127903G>C	uc001ezs.1	-	3	1737	c.1672C>G	c.(1672-1674)CAC>GAC	p.H558D		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	558	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGACCGTAGTGGGAACTCTGG	0.507													166	694	---	---	---	---	PASS
SPTA1	6708	broad.mit.edu	37	1	158632635	158632635	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:158632635C>A	uc001fst.1	-	17	2520	c.2321G>T	c.(2320-2322)CGA>CTA	p.R774L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	774	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGCTTCAAATCGGCATACCAA	0.478													9	63	---	---	---	---	PASS
FCER1A	2205	broad.mit.edu	37	1	159275988	159275988	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:159275988G>T	uc001ftq.2	+	5	641	c.542G>T	c.(541-543)TGG>TTG	p.W181L		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	181	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GGCAAAGTGTGGCAGCTGGAC	0.453													39	33	---	---	---	---	PASS
FCER1A	2205	broad.mit.edu	37	1	159275989	159275989	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:159275989G>T	uc001ftq.2	+	5	642	c.543G>T	c.(541-543)TGG>TGT	p.W181C		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	181	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GCAAAGTGTGGCAGCTGGACT	0.453													41	32	---	---	---	---	PASS
FCER1A	2205	broad.mit.edu	37	1	159277608	159277608	+	Silent	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:159277608A>G	uc001ftq.2	+	6	759	c.660A>G	c.(658-660)ACA>ACG	p.T220T		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	220	Helical; (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CTGTGGACACAGGATTATTTA	0.438													24	100	---	---	---	---	PASS
IGSF8	93185	broad.mit.edu	37	1	160064847	160064847	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:160064847T>A	uc001fva.2	-	2	299	c.254A>T	c.(253-255)CAG>CTG	p.Q85L	IGSF8_uc001fuz.2_Missense_Mutation_p.Q85L|IGSF8_uc009wtf.2_Missense_Mutation_p.Q85L	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	85	Ig-like C2-type 1.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ATAGGAGAACTGGGTATCCTT	0.597													43	29	---	---	---	---	PASS
CRB1	23418	broad.mit.edu	37	1	197411333	197411333	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:197411333T>C	uc001gtz.2	+	11	4051	c.3916T>C	c.(3916-3918)TGT>CGT	p.C1306R	CRB1_uc010poz.1_Missense_Mutation_p.C1282R|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.C1194R|CRB1_uc010ppb.1_Missense_Mutation_p.C770R|CRB1_uc010ppd.1_Missense_Mutation_p.C787R|CRB1_uc001gub.1_3'UTR	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1306	Extracellular (Potential).|EGF-like 19; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTCTGATCCGTGTGTCAATGG	0.493													95	97	---	---	---	---	PASS
PTPN7	5778	broad.mit.edu	37	1	202128422	202128422	+	Nonsense_Mutation	SNP	G	A	A	rs149516769		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:202128422G>A	uc001gxm.1	-	2	240	c.109C>T	c.(109-111)CGA>TGA	p.R37*	PTPN7_uc001gxl.1_Nonsense_Mutation_p.R76*|PTPN7_uc001gxn.1_Nonsense_Mutation_p.R37*|PTPN7_uc010ppv.1_5'UTR|PTPN7_uc010ppw.1_Silent_p.C2C|PTPN7_uc010ppx.1_Nonsense_Mutation_p.R111*|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_5'Flank	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	37						cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						TCCTGCAGTCGCACATGCTTC	0.632													6	30	---	---	---	---	PASS
ARID4B	51742	broad.mit.edu	37	1	235345290	235345290	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr1:235345290C>A	uc001hwq.2	-	20	3442	c.2944G>T	c.(2944-2946)GTA>TTA	p.V982L	ARID4B_uc001hwr.2_Missense_Mutation_p.V896L|ARID4B_uc001hws.3_Missense_Mutation_p.V896L|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.V663L	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	982					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TCTAGTTCTACACTGGGTGAA	0.498													33	149	---	---	---	---	PASS
RSAD2	91543	broad.mit.edu	37	2	7027158	7027158	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:7027158G>A	uc002qyp.1	+	3	737	c.601G>A	c.(601-603)GTG>ATG	p.V201M		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	201					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GAAGAACCATGTGGAAAACCT	0.448													14	38	---	---	---	---	PASS
TMEM178	130733	broad.mit.edu	37	2	39944267	39944267	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:39944267C>T	uc002rrt.2	+	4	795	c.770C>T	c.(769-771)TCC>TTC	p.S257F	TMEM178_uc010fam.1_Missense_Mutation_p.S211F	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	257	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				TACAGCTGGTCCATCTTTTGC	0.488													62	62	---	---	---	---	PASS
SLC8A1	6546	broad.mit.edu	37	2	40656327	40656327	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:40656327C>A	uc002rrx.2	-	1	1118	c.1094G>T	c.(1093-1095)CGC>CTC	p.R365L	SLC8A1_uc002rry.2_Missense_Mutation_p.R365L|SLC8A1_uc002rrz.2_Missense_Mutation_p.R365L|SLC8A1_uc002rsa.2_Missense_Mutation_p.R365L|SLC8A1_uc002rsd.3_Missense_Mutation_p.R365L|SLC8A1_uc002rsb.1_Missense_Mutation_p.R365L|SLC8A1_uc010fan.1_Missense_Mutation_p.R365L|SLC8A1_uc002rsc.1_Missense_Mutation_p.R365L	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	365	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGCTTGAATGCGATAAAATGC	0.428													23	133	---	---	---	---	PASS
SPRED2	200734	broad.mit.edu	37	2	65541258	65541258	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:65541258C>G	uc002sdr.3	-	6	1169	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	SPRED2_uc010fcw.2_Missense_Mutation_p.E209Q	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	212	KBD.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						ACGATCTCCTCGTCGTCGTCC	0.597													16	26	---	---	---	---	PASS
TGOLN2	10618	broad.mit.edu	37	2	85553695	85553695	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:85553695G>A	uc010fgd.1	-	2	1449	c.1160C>T	c.(1159-1161)GCA>GTA	p.A387V	TGOLN2_uc002soz.2_Missense_Mutation_p.A387V|TGOLN2_uc002spa.2_RNA|TGOLN2_uc002spb.2_Missense_Mutation_p.A329V|TGOLN2_uc002spc.1_Missense_Mutation_p.A387V	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	387	Helical; (Potential).					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CACCAGATATGCAAAGAAGTG	0.547													58	46	---	---	---	---	PASS
PKP4	8502	broad.mit.edu	37	2	159481743	159481743	+	Silent	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:159481743G>C	uc002tzv.2	+	7	1217	c.957G>C	c.(955-957)ACG>ACC	p.T319T	PKP4_uc002tzt.1_Silent_p.T171T|PKP4_uc002tzu.2_Silent_p.T319T|PKP4_uc002tzw.2_Silent_p.T319T|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Silent_p.T317T|PKP4_uc002uaa.2_Silent_p.T171T	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	319					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TGACCCTGACGGATGCACAGA	0.627										HNSCC(62;0.18)			15	39	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179446758	179446758	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:179446758C>G	uc010zfg.1	-	264	58858	c.58634G>C	c.(58633-58635)AGA>ACA	p.R19545T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R13240T|TTN_uc010zfi.1_Missense_Mutation_p.R13173T|TTN_uc010zfj.1_Missense_Mutation_p.R13048T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20472							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTAATGTTCTTTCTATAAT	0.448													43	108	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179569457	179569457	+	Silent	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:179569457A>G	uc010zfg.1	-	102	26234	c.26010T>C	c.(26008-26010)GAT>GAC	p.D8670D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.D5331D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9597							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCATCATTATCTTTCAAAA	0.318													14	21	---	---	---	---	PASS
CCDC141	285025	broad.mit.edu	37	2	179718286	179718286	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:179718286G>T	uc002unf.1	-	10	1458	c.1401C>A	c.(1399-1401)TGC>TGA	p.C467*		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	467							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCTTTGTCTTGCACTCTGTGG	0.413													17	48	---	---	---	---	PASS
ZSWIM2	151112	broad.mit.edu	37	2	187693346	187693346	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:187693346C>A	uc002upu.1	-	9	1307	c.1267G>T	c.(1267-1269)GAT>TAT	p.D423Y		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	423					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATAAAAAGATCTGGTTCTTTC	0.338													25	32	---	---	---	---	PASS
SF3B1	23451	broad.mit.edu	37	2	198262836	198262836	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:198262836C>A	uc002uue.2	-	22	3187	c.3139G>T	c.(3139-3141)GCT>TCT	p.A1047S		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1047	HEAT 8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ACATATTCAGCTCCCCTAATT	0.323													27	71	---	---	---	---	PASS
HSPD1	3329	broad.mit.edu	37	2	198361921	198361921	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:198361921C>G	uc002uui.2	-	3	507	c.370G>C	c.(370-372)GCC>CCC	p.A124P	HSPD1_uc002uuj.2_Missense_Mutation_p.A124P|HSPD1_uc010zgx.1_Missense_Mutation_p.A124P|HSPD1_uc010fsm.2_Intron|HSPD1_uc002uuk.2_Missense_Mutation_p.A124P|HSPD1_uc010zgy.1_Missense_Mutation_p.A124P|HSPE1_uc002uul.2_5'Flank	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	124					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			CCTTCCTTGGCTATAGAGCGT	0.443													24	49	---	---	---	---	PASS
PARD3B	117583	broad.mit.edu	37	2	206023531	206023531	+	Missense_Mutation	SNP	C	T	T	rs149158367		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:206023531C>T	uc002var.1	+	11	1727	c.1520C>T	c.(1519-1521)GCT>GTT	p.A507V	PARD3B_uc010fub.1_Missense_Mutation_p.A507V|PARD3B_uc002vao.1_Missense_Mutation_p.A507V|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Missense_Mutation_p.A507V	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	507	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TCAGGTTCTGCTGGCCTCGGG	0.483													34	65	---	---	---	---	PASS
DNER	92737	broad.mit.edu	37	2	230272008	230272008	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr2:230272008C>G	uc002vpv.2	-	10	1810	c.1663G>C	c.(1663-1665)GGA>CGA	p.G555R		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	555	Extracellular (Potential).|Follistatin-like.|EGF-like 9.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CAGGTGGCTCCGTTCAGACAG	0.512													13	70	---	---	---	---	PASS
ABHD6	57406	broad.mit.edu	37	3	58279428	58279428	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:58279428C>T	uc003djs.3	+	9	1360	c.950C>T	c.(949-951)GCC>GTC	p.A317V	ABHD6_uc003djr.2_Missense_Mutation_p.A318V|ABHD6_uc003djt.3_Missense_Mutation_p.A317V	NM_020676	NP_065727	Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	317	Cytoplasmic (Potential).					integral to membrane	acylglycerol lipase activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		AGGAAGACAGCCAAGCTCATA	0.517													16	8	---	---	---	---	PASS
EPHA6	285220	broad.mit.edu	37	3	96533582	96533582	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:96533582G>A	uc010how.1	+	1	158	c.115G>A	c.(115-117)GGG>AGG	p.G39R	EPHA6_uc003drp.1_Missense_Mutation_p.G39R	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	Error:Variant_position_missing_in_Q9UF33_after_alignment						integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CCCTGTTCCCGGGACCTCGCG	0.637													5	15	---	---	---	---	PASS
GPR128	84873	broad.mit.edu	37	3	100373989	100373989	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:100373989C>T	uc003duc.2	+	12	1958	c.1690C>T	c.(1690-1692)CGG>TGG	p.R564W	GPR128_uc011bhc.1_Missense_Mutation_p.R265W|GPR128_uc003dud.2_Missense_Mutation_p.R87W	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	564	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GCCTCTTCCTCGGCATTTCAT	0.383													18	84	---	---	---	---	PASS
KIAA1524	57650	broad.mit.edu	37	3	108300348	108300348	+	Missense_Mutation	SNP	C	G	G	rs138065901	byFrequency	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:108300348C>G	uc003dxb.3	-	5	732	c.463G>C	c.(463-465)GAA>CAA	p.E155Q	KIAA1524_uc003dxc.1_5'UTR|KIAA1524_uc010hpw.1_5'UTR	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	155						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						AACTCATCTTCAGAAGATTGA	0.284													5	34	---	---	---	---	PASS
CCDC80	151887	broad.mit.edu	37	3	112357186	112357186	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:112357186C>A	uc003dzf.2	-	2	1785	c.1567G>T	c.(1567-1569)GAG>TAG	p.E523*	CCDC80_uc011bhv.1_Nonsense_Mutation_p.E523*|CCDC80_uc003dzg.2_Nonsense_Mutation_p.E523*|CCDC80_uc003dzh.1_Nonsense_Mutation_p.E523*	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	523	Lys-rich.									ovary(2)	2						ACCTGCAGCTCGTCCTCCAGC	0.408													25	57	---	---	---	---	PASS
SLC12A8	84561	broad.mit.edu	37	3	124807181	124807181	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:124807181A>T	uc003ehv.3	-	13	2066	c.1955T>A	c.(1954-1956)ATG>AAG	p.M652K	SLC12A8_uc003ehw.3_Missense_Mutation_p.M681K|SLC12A8_uc003eht.3_Missense_Mutation_p.M453K|SLC12A8_uc003ehu.3_Missense_Mutation_p.M405K|SLC12A8_uc010hry.2_Intron	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	652					potassium ion transport	integral to membrane	symporter activity				0						GAGAGACCTCATCCACCGGAA	0.498													16	32	---	---	---	---	PASS
PODXL2	50512	broad.mit.edu	37	3	127379397	127379397	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:127379397G>C	uc003ejq.2	+	3	550	c.526G>C	c.(526-528)GAA>CAA	p.E176Q		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	176	Extracellular (Potential).|Glu-rich.				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						gagggagaaggaagaggtaga	0.333													10	33	---	---	---	---	PASS
TXNDC6	347736	broad.mit.edu	37	3	138025270	138025270	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:138025270G>T	uc003esg.2	-	7	541	c.513C>A	c.(511-513)GCC>GCA	p.A171A	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Silent_p.A86A|TXNDC6_uc003ese.1_Silent_p.A110A	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	171	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						TCTTTCCATGGGCCACTGCAT	0.463													20	41	---	---	---	---	PASS
NMD3	51068	broad.mit.edu	37	3	160952598	160952598	+	Silent	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:160952598A>G	uc003feb.1	+	6	560	c.441A>G	c.(439-441)GTA>GTG	p.V147V	NMD3_uc003fec.2_Silent_p.V147V|NMD3_uc003fed.1_Silent_p.V147V|NMD3_uc010hwh.2_5'Flank	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	147					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			GCCATAGAGTAGAAGCTAAGG	0.383													18	67	---	---	---	---	PASS
BCHE	590	broad.mit.edu	37	3	165547449	165547449	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:165547449C>A	uc003fem.3	-	2	1533	c.1373G>T	c.(1372-1374)TGG>TTG	p.W458L	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	458					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CCATTCTGGCCACGGAAGTTT	0.403													16	88	---	---	---	---	PASS
TNIK	23043	broad.mit.edu	37	3	170797378	170797378	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:170797378T>G	uc003fhh.2	-	28	3722	c.3377A>C	c.(3376-3378)GAC>GCC	p.D1126A	TNIK_uc003fhi.2_Missense_Mutation_p.D1071A|TNIK_uc003fhj.2_Missense_Mutation_p.D1097A|TNIK_uc003fhk.2_Missense_Mutation_p.D1118A|TNIK_uc003fhl.2_Missense_Mutation_p.D1042A|TNIK_uc003fhm.2_Missense_Mutation_p.D1063A|TNIK_uc003fhn.2_Missense_Mutation_p.D1089A|TNIK_uc003fho.2_Missense_Mutation_p.D1034A|TNIK_uc003fhg.2_Missense_Mutation_p.D304A|TNIK_uc003fhp.2_Missense_Mutation_p.D58A	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1126	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TACTTCTGGGTCATTATGTAG	0.338													8	31	---	---	---	---	PASS
ABCF3	55324	broad.mit.edu	37	3	183910653	183910653	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:183910653T>A	uc003fmz.2	+	18	1852	c.1719T>A	c.(1717-1719)AGT>AGA	p.S573R	ABCF3_uc003fna.2_Missense_Mutation_p.S567R|ABCF3_uc003fnb.2_Missense_Mutation_p.S254R	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	573	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TAAACGTCAGTGCTGTGGAAC	0.542													18	44	---	---	---	---	PASS
C3orf70	285382	broad.mit.edu	37	3	184870445	184870445	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:184870445T>A	uc003fpd.2	-	1	358	c.167A>T	c.(166-168)CAC>CTC	p.H56L		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	56											0						ACAGCACCAGTGCAGCTTGAA	0.697													8	8	---	---	---	---	PASS
MASP1	5648	broad.mit.edu	37	3	186971078	186971078	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:186971078C>T	uc003frh.1	-	6	1102	c.770G>A	c.(769-771)GGG>GAG	p.G257E	MASP1_uc003fri.2_Missense_Mutation_p.G257E|MASP1_uc003frj.2_Missense_Mutation_p.G226E|MASP1_uc003frk.1_Missense_Mutation_p.G257E|MASP1_uc011bse.1_Missense_Mutation_p.G231E	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	257	Interaction with FCN2.|CUB 2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		ACAGAAAGGCCCCAAAACTTT	0.507													61	151	---	---	---	---	PASS
PIGZ	80235	broad.mit.edu	37	3	196674943	196674943	+	Silent	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr3:196674943C>T	uc003fxh.2	-	3	972	c.825G>A	c.(823-825)ACG>ACA	p.T275T		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	275	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		ACCAGCTGTCCGTGGCCACAA	0.592													12	41	---	---	---	---	PASS
KCTD8	386617	broad.mit.edu	37	4	44177020	44177020	+	Silent	SNP	T	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:44177020T>G	uc003gwu.2	-	2	1493	c.1209A>C	c.(1207-1209)CCA>CCC	p.P403P		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	403						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GTTTGTCTGGTGGGGGTATCC	0.483										HNSCC(17;0.042)			52	135	---	---	---	---	PASS
GABRB1	2560	broad.mit.edu	37	4	47428023	47428023	+	Silent	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:47428023C>T	uc003gxh.2	+	9	1787	c.1413C>T	c.(1411-1413)TAC>TAT	p.Y471Y	GABRB1_uc011bze.1_Silent_p.Y401Y	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	471	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATTGGCTTTACTATGTACACT	0.403													36	65	---	---	---	---	PASS
MIR1269	100302177	broad.mit.edu	37	4	67142637	67142637	+	RNA	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:67142637G>C	hsa-mir-1269|MI0006406	+			c.96G>C																				0						tggcttccctggtctccagct	0.000													12	25	---	---	---	---	PASS
FRAS1	80144	broad.mit.edu	37	4	79387483	79387483	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:79387483G>T	uc003hlb.2	+	50	7591	c.7151G>T	c.(7150-7152)CGG>CTG	p.R2384L		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2383	CSPG 11.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TACCAGAACCGGGTCAGCTAC	0.537													16	19	---	---	---	---	PASS
AFF1	4299	broad.mit.edu	37	4	87968236	87968236	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:87968236A>T	uc003hqj.3	+	3	935	c.528A>T	c.(526-528)AAA>AAT	p.K176N	AFF1_uc011ccx.1_Missense_Mutation_p.K117N|AFF1_uc003hqh.1_Missense_Mutation_p.K183N|AFF1_uc011ccy.1_Missense_Mutation_p.K183N|AFF1_uc011ccz.1_Missense_Mutation_p.K183N|AFF1_uc003hqk.3_Missense_Mutation_p.K176N|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	176						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		ATCACAAGAAAGGTGACCGAA	0.582													22	44	---	---	---	---	PASS
BANK1	55024	broad.mit.edu	37	4	102751013	102751013	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:102751013G>T	uc003hvy.3	+	2	393	c.119G>T	c.(118-120)TGG>TTG	p.W40L	BANK1_uc003hvx.3_Missense_Mutation_p.W25L|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Missense_Mutation_p.W10L	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	40	Interaction with ITPR2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GCTGAGGAATGGGCTCTGTAC	0.338													11	30	---	---	---	---	PASS
BANK1	55024	broad.mit.edu	37	4	102751014	102751014	+	Missense_Mutation	SNP	G	T	T	rs35978636	byFrequency	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:102751014G>T	uc003hvy.3	+	2	394	c.120G>T	c.(118-120)TGG>TGT	p.W40C	BANK1_uc003hvx.3_Missense_Mutation_p.W25C|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Missense_Mutation_p.W10C	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	40	Interaction with ITPR2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CTGAGGAATGGGCTCTGTACT	0.338													11	31	---	---	---	---	PASS
KIAA1109	84162	broad.mit.edu	37	4	123107280	123107280	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:123107280G>T	uc003ieh.2	+	5	493	c.448G>T	c.(448-450)GAG>TAG	p.E150*	KIAA1109_uc003iei.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	150					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ACGCCTTCAAGAGTTGTTTGG	0.383													19	32	---	---	---	---	PASS
ANKRD50	57182	broad.mit.edu	37	4	125591992	125591992	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:125591992C>T	uc003ifg.3	-	3	2706	c.2440G>A	c.(2440-2442)GGT>AGT	p.G814S	ANKRD50_uc011cgo.1_Missense_Mutation_p.G635S|ANKRD50_uc010inw.2_Missense_Mutation_p.G814S	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	814	ANK 11.									central_nervous_system(1)	1						ACTGTCCTACCTTCACTATCA	0.458													34	52	---	---	---	---	PASS
FSTL5	56884	broad.mit.edu	37	4	162307058	162307058	+	Silent	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:162307058C>G	uc003iqh.2	-	16	2821	c.2385G>C	c.(2383-2385)CGG>CGC	p.R795R	FSTL5_uc003iqi.2_Silent_p.R794R|FSTL5_uc010iqv.2_Silent_p.R785R|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	795						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GCCTGTTTTTCCGGTTCCAAG	0.453													27	82	---	---	---	---	PASS
CLCN3	1182	broad.mit.edu	37	4	170618424	170618424	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr4:170618424C>G	uc003isi.2	+	9	1611	c.1102C>G	c.(1102-1104)CCA>GCA	p.P368A	CLCN3_uc003ish.2_Missense_Mutation_p.P368A|CLCN3_uc011cjz.1_Missense_Mutation_p.P351A|CLCN3_uc011cka.1_Missense_Mutation_p.P341A|CLCN3_uc003isj.1_Missense_Mutation_p.P341A	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	368					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GTCCATCAATCCATTTGGTAA	0.363													48	71	---	---	---	---	PASS
HAPLN1	1404	broad.mit.edu	37	5	82948380	82948380	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:82948380C>T	uc003kim.2	-	2	435	c.364G>A	c.(364-366)GCT>ACT	p.A122T	HAPLN1_uc003kin.2_Missense_Mutation_p.A122T	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	122	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		ACCAGAGAAGCATCACTATCA	0.443													16	94	---	---	---	---	PASS
GPR98	84059	broad.mit.edu	37	5	89989783	89989783	+	Missense_Mutation	SNP	G	A	A	rs78203228	by1000genomes	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:89989783G>A	uc003kju.2	+	33	7306	c.7210G>A	c.(7210-7212)GGT>AGT	p.G2404S	GPR98_uc003kjt.2_Missense_Mutation_p.G110S|GPR98_uc003kjv.2_Missense_Mutation_p.G4S	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2404	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGGAGGAAGGTCAAGATTT	0.483													5	21	---	---	---	---	PASS
ST8SIA4	7903	broad.mit.edu	37	5	100222203	100222203	+	Missense_Mutation	SNP	C	T	T	rs150785295		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:100222203C>T	uc003knk.2	-	3	675	c.347G>A	c.(346-348)CGG>CAG	p.R116Q	ST8SIA4_uc003knl.2_Missense_Mutation_p.R116Q	NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	116	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GTTTAGTGTCCGGCGCCTGTC	0.438													34	23	---	---	---	---	PASS
ISOC1	51015	broad.mit.edu	37	5	128448670	128448670	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:128448670G>T	uc003kva.2	+	5	891	c.873G>T	c.(871-873)GAG>GAT	p.E291D		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	291						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		GTGCTCCAGAGTCGGGTCTGC	0.463													53	26	---	---	---	---	PASS
TGFBI	7045	broad.mit.edu	37	5	135383035	135383035	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:135383035G>A	uc003lbf.3	+	6	858	c.697G>A	c.(697-699)GAT>AAT	p.D233N	TGFBI_uc003lbg.3_5'UTR|TGFBI_uc003lbh.3_Missense_Mutation_p.D59N|TGFBI_uc011cyb.1_Missense_Mutation_p.D59N|TGFBI_uc010jed.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	233	FAS1 1.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCACCTCATCGATAAGGTCAT	0.557													52	102	---	---	---	---	PASS
PCDHA2	56146	broad.mit.edu	37	5	140175375	140175375	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:140175375G>T	uc003lhd.2	+	1	932	c.826G>T	c.(826-828)GAG>TAG	p.E276*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Nonsense_Mutation_p.E276*|PCDHA2_uc011czy.1_Nonsense_Mutation_p.E276*	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGAACAGCGAGATTGTGTA	0.408													51	19	---	---	---	---	PASS
PCDHB8	56128	broad.mit.edu	37	5	140559232	140559232	+	Silent	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:140559232C>G	uc011dai.1	+	1	1803	c.1617C>G	c.(1615-1617)TCC>TCG	p.S539S	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	539	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCGCGGCTCCCCGGCTTTGA	0.672													27	56	---	---	---	---	PASS
PCDHGB2	56103	broad.mit.edu	37	5	140740790	140740790	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:140740790G>A	uc003ljs.1	+	1	1088	c.1088G>A	c.(1087-1089)GGA>GAA	p.G363E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.G363E	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	363	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCCACCAGGAACAGTGATC	0.428													36	18	---	---	---	---	PASS
PCDHGA10	56106	broad.mit.edu	37	5	140793345	140793345	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr5:140793345G>A	uc003lkl.1	+	1	603	c.603G>A	c.(601-603)GAG>GAA	p.E201E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.E201E	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	201	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTACTGGAGCACTCCCTAG	0.587													13	14	---	---	---	---	PASS
ZKSCAN3	80317	broad.mit.edu	37	6	28327755	28327755	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:28327755C>T	uc003nle.3	+	2	608	c.392C>T	c.(391-393)CCG>CTG	p.P131L	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.P131L|ZKSCAN3_uc003nlf.3_Intron	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	131					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						CTGGATGAGCCGGCGCCGCAG	0.562													4	10	---	---	---	---	PASS
OR12D2	26529	broad.mit.edu	37	6	29364842	29364842	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:29364842G>T	uc003nmf.3	+	1	427	c.366G>T	c.(364-366)GTG>GTT	p.V122V		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACCTCTCTGTGGCTATCTGCA	0.507													8	30	---	---	---	---	PASS
EHMT2	10919	broad.mit.edu	37	6	31854777	31854777	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:31854777G>A	uc003nxz.1	-	16	2123	c.2113C>T	c.(2113-2115)CTG>TTG	p.L705L	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.L496L|EHMT2_uc011don.1_Silent_p.L728L|EHMT2_uc003nya.1_Silent_p.L671L	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	705	ANK 2.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CTGACCTGCAGCAGCACATGG	0.687													4	62	---	---	---	---	PASS
TNXB	7148	broad.mit.edu	37	6	32037465	32037465	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:32037465G>T	uc003nzl.2	-	15	5654	c.5452C>A	c.(5452-5454)CAG>AAG	p.Q1818K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1900	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCACCACCTGGGGCTGCCCG	0.657													9	8	---	---	---	---	PASS
TFAP2D	83741	broad.mit.edu	37	6	50683050	50683050	+	Silent	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:50683050C>G	uc003paf.2	+	2	773	c.261C>G	c.(259-261)CCC>CCG	p.P87P	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	87							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CCGTCACCCCCGACGCCTACT	0.587													16	36	---	---	---	---	PASS
PRIM2	5558	broad.mit.edu	37	6	57472357	57472357	+	Splice_Site	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:57472357A>T	uc003pdx.2	+	13	1235	c.1148_splice	c.e13-2	p.G383_splice		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTTTGTTGTCAGGGTGCCCAT	0.438													5	25	---	---	---	---	PASS
KCNQ5	56479	broad.mit.edu	37	6	73904327	73904327	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:73904327C>A	uc003pgk.2	+	14	2336	c.1989C>A	c.(1987-1989)AGC>AGA	p.S663R	KCNQ5_uc011dyh.1_Missense_Mutation_p.S682R|KCNQ5_uc011dyi.1_Missense_Mutation_p.S673R|KCNQ5_uc010kat.2_Missense_Mutation_p.S654R|KCNQ5_uc011dyj.1_Missense_Mutation_p.S553R|KCNQ5_uc011dyk.1_Missense_Mutation_p.S413R	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	663					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CTGTGGATAGCAAAGATCTTT	0.493													18	43	---	---	---	---	PASS
GPR63	81491	broad.mit.edu	37	6	97247581	97247581	+	Silent	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:97247581C>A	uc010kcl.2	-	3	505	c.27G>T	c.(25-27)GCG>GCT	p.A9A	GPR63_uc003pou.2_Silent_p.A9A	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	9	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		CGGTATGGAACGCAGTCAACA	0.463													18	31	---	---	---	---	PASS
HACE1	57531	broad.mit.edu	37	6	105233141	105233141	+	Silent	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:105233141T>A	uc003pqu.1	-	12	1405	c.1128A>T	c.(1126-1128)ACA>ACT	p.T376T	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Silent_p.T376T|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Silent_p.T29T	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	376					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TCATCAATTCTGTGGCTATTA	0.363													17	31	---	---	---	---	PASS
POPDC3	64208	broad.mit.edu	37	6	105609387	105609387	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:105609387G>A	uc003prb.2	-	2	800	c.398C>T	c.(397-399)TCT>TTT	p.S133F	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	133						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				AACCACTTCAGAGCTCAAAGC	0.463													21	46	---	---	---	---	PASS
ZBTB24	9841	broad.mit.edu	37	6	109802864	109802864	+	Silent	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:109802864T>A	uc003ptl.1	-	2	534	c.366A>T	c.(364-366)GTA>GTT	p.V122V	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Silent_p.V122V|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Silent_p.V122V	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	122	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TGTAAGCCTTTACCAGGTCAT	0.418													26	105	---	---	---	---	PASS
AKD1	221264	broad.mit.edu	37	6	109996906	109996906	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:109996906T>C	uc003ptn.2	-	2	120	c.43A>G	c.(43-45)ATA>GTA	p.I15V	AKD1_uc003ptr.3_Missense_Mutation_p.I15V|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	15					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCATCAAATATATCTGCAAAA	0.313													11	33	---	---	---	---	PASS
LPA	4018	broad.mit.edu	37	6	161015040	161015040	+	Silent	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:161015040G>C	uc003qtl.2	-	23	3699	c.3579C>G	c.(3577-3579)TCC>TCG	p.S1193S		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3701	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTGTCATAGAGGACCAAGACT	0.483													24	37	---	---	---	---	PASS
EIF3B	8662	broad.mit.edu	37	7	2415136	2415136	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:2415136A>C	uc003slx.2	+	14	2085	c.2002A>C	c.(2002-2004)ACC>CCC	p.T668P	EIF3B_uc003sly.2_Missense_Mutation_p.T668P|EIF3B_uc003sma.2_Missense_Mutation_p.T396P|EIF3B_uc003smb.2_5'Flank	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	668	WD 5.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTACGTCGTCACCTCTGTGTC	0.562													4	47	---	---	---	---	PASS
PAPOLB	56903	broad.mit.edu	37	7	4901276	4901276	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:4901276C>T	uc003snk.2	-	1	350	c.166G>A	c.(166-168)GAA>AAA	p.E56K	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	55					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AGTTCCTCTTCCTCTTCGAAG	0.502													8	15	---	---	---	---	PASS
ZNF804B	219578	broad.mit.edu	37	7	88963179	88963179	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:88963179A>G	uc011khi.1	+	4	1421	c.883A>G	c.(883-885)ACC>GCC	p.T295A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	295						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTACACAATACCATCTCCAT	0.358										HNSCC(36;0.09)			13	27	---	---	---	---	PASS
NAA38	51691	broad.mit.edu	37	7	117828443	117828443	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:117828443G>T	uc003vjg.2	+	3	376	c.184G>T	c.(184-186)GTA>TTA	p.V62L		NM_016200	NP_057284	O95777	NAA38_HUMAN	U6 snRNA-associated Sm-like protein LSm8	62					nuclear mRNA splicing, via spliceosome	nucleus|ribonucleoprotein complex	protein binding|U6 snRNA binding				0						ATTATACATTGTAAGAGGTGA	0.363													8	35	---	---	---	---	PASS
FAM3C	10447	broad.mit.edu	37	7	121011442	121011442	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:121011442T>C	uc003vjx.2	-	5	432	c.184A>G	c.(184-186)AAA>GAA	p.K62E	FAM3C_uc010lkm.2_Missense_Mutation_p.K62E	NM_014888	NP_055703	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	62					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)					GGGCAAGCTTTTGAGATCCCA	0.413													37	41	---	---	---	---	PASS
AKR1B1	231	broad.mit.edu	37	7	134130009	134130009	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:134130009T>C	uc003vrp.1	-	9	963	c.889A>G	c.(889-891)AGG>GGG	p.R297G	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	297					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	GCACAGACCCTCCAGTTCCTG	0.488													2	7	---	---	---	---	PASS
BPGM	669	broad.mit.edu	37	7	134346768	134346768	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:134346768A>G	uc003vrv.2	+	3	1050	c.509A>G	c.(508-510)AAT>AGT	p.N170S	BPGM_uc003vrw.2_Missense_Mutation_p.N170S|BPGM_uc003vrx.2_Missense_Mutation_p.N170S	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	170					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CCCTATTGGAATGAAAGGATT	0.473													22	35	---	---	---	---	PASS
KIAA1549	57670	broad.mit.edu	37	7	138604053	138604053	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:138604053G>A	uc011kql.1	-	2	368	c.319C>T	c.(319-321)CTC>TTC	p.L107F	KIAA1549_uc003vuk.3_Missense_Mutation_p.L57F|KIAA1549_uc011kqj.1_Missense_Mutation_p.L107F	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	107						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GTGACATGGAGAGGACTGCTG	0.517			O	BRAF	pilocytic astrocytoma								19	46	---	---	---	---	PASS
OR6B1	135946	broad.mit.edu	37	7	143701563	143701563	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr7:143701563G>A	uc003wdt.1	+	1	474	c.474G>A	c.(472-474)GCG>GCA	p.A158A		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TCTCCCTGGCGAAGATCTACT	0.532													11	17	---	---	---	---	PASS
BIN3	55909	broad.mit.edu	37	8	22488075	22488075	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr8:22488075G>A	uc003xcl.2	-	5	274	c.177C>T	c.(175-177)GCC>GCT	p.A59A	BIN3_uc003xck.2_Silent_p.A11A|BIN3_uc010ltw.2_Silent_p.A5A	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	59	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		ATATCTTCACGGCAGATTTTG	0.557													5	11	---	---	---	---	PASS
EBF2	64641	broad.mit.edu	37	8	25715978	25715978	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr8:25715978G>C	uc003xes.1	-	14	1402	c.1385C>G	c.(1384-1386)TCT>TGT	p.S462C	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	462	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGAGCTGGAAGAGTATCCCCG	0.517													3	29	---	---	---	---	PASS
WHSC1L1	54904	broad.mit.edu	37	8	38162894	38162894	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr8:38162894C>A	uc003xli.2	-	13	2830	c.2312G>T	c.(2311-2313)GGG>GTG	p.G771V	WHSC1L1_uc011lbm.1_Missense_Mutation_p.G771V|WHSC1L1_uc010lwe.2_Missense_Mutation_p.G771V	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	771	PHD-type 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			ATAAAATTTCCCACAAGCACC	0.448			T	NUP98	AML								12	171	---	---	---	---	PASS
MMP16	4325	broad.mit.edu	37	8	89128831	89128831	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr8:89128831T>C	uc003yeb.3	-	6	1270	c.988A>G	c.(988-990)ACC>GCC	p.T330A	MMP16_uc003yec.2_Missense_Mutation_p.T330A	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	330	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GGTCTGCCGGTTGGAGGCCGA	0.532													18	39	---	---	---	---	PASS
DAPK1	1612	broad.mit.edu	37	9	90321440	90321440	+	Silent	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:90321440C>T	uc004apc.2	+	26	3592	c.3454C>T	c.(3454-3456)CTG>TTG	p.L1152L	DAPK1_uc004apd.2_Silent_p.L1152L|DAPK1_uc011ltg.1_Silent_p.L1086L|DAPK1_uc011lth.1_Silent_p.L889L|DAPK1_uc004apg.2_Silent_p.L129L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1152					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CCAGGTGAACCTGTGCCGGTG	0.627									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				15	8	---	---	---	---	PASS
GRIN3A	116443	broad.mit.edu	37	9	104432474	104432474	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:104432474C>A	uc004bbp.1	-	3	2821	c.2220G>T	c.(2218-2220)TGG>TGT	p.W740C	GRIN3A_uc004bbq.1_Missense_Mutation_p.W740C	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	740	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ACCTTCCAGTCCAACATTTTG	0.438													14	34	---	---	---	---	PASS
TMEM38B	55151	broad.mit.edu	37	9	108483984	108483984	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:108483984G>A	uc004bcu.1	+	3	553	c.436G>A	c.(436-438)GCT>ACT	p.A146T	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	146	Helical; (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						AGTCATGATAGCTATTGGATG	0.368													19	7	---	---	---	---	PASS
GOLGA2	2801	broad.mit.edu	37	9	131019402	131019402	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:131019402T>C	uc011maw.1	-	26	2966	c.2953A>G	c.(2953-2955)ATT>GTT	p.I985V	GOLGA2_uc010mxw.2_Missense_Mutation_p.I308V|GOLGA2_uc004buh.2_Missense_Mutation_p.I335V	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	985						Golgi cisterna membrane	protein binding			ovary(1)	1						AAAAAAGGAATGCAGGGGTTG	0.557													68	36	---	---	---	---	PASS
NOTCH1	4851	broad.mit.edu	37	9	139412675	139412675	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:139412675T>C	uc004chz.2	-	7	1169	c.1169A>G	c.(1168-1170)AAC>AGC	p.N390S		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	390	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATTGACAGGGTTGGTGTCGCA	0.662			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	8	---	---	---	---	PASS
EHMT1	79813	broad.mit.edu	37	9	140605444	140605444	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr9:140605444A>T	uc011mfc.1	+	2	84	c.47A>T	c.(46-48)CAG>CTG	p.Q16L	EHMT1_uc004coa.2_Missense_Mutation_p.Q16L|EHMT1_uc004cob.1_Intron	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	16					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GGGGAGCCTCAGCAGGATTGC	0.582													3	0	---	---	---	---	PASS
DIP2C	22982	broad.mit.edu	37	10	323266	323266	+	Nonstop_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:323266T>A	uc001ifp.2	-	37	4760	c.4670A>T	c.(4669-4671)TAG>TTG	p.*1557L		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1557						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GAGACGAGACTACATGTTGTA	0.527													6	30	---	---	---	---	PASS
GTPBP4	23560	broad.mit.edu	37	10	1058523	1058523	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:1058523G>A	uc001ift.2	+	14	1534	c.1463G>A	c.(1462-1464)CGA>CAA	p.R488Q	GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.R372Q|GTPBP4_uc010qae.1_Missense_Mutation_p.R441Q	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	488					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		AAGCAAATTCGAGAGAAAAAG	0.443													9	23	---	---	---	---	PASS
MPP7	143098	broad.mit.edu	37	10	28348580	28348580	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:28348580T>C	uc001iua.1	-	16	1701	c.1297A>G	c.(1297-1299)AAG>GAG	p.K433E	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.K433E|MPP7_uc009xla.2_Missense_Mutation_p.K433E|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	433	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TCCACATACTTGTTATTTTGT	0.358													14	30	---	---	---	---	PASS
SVIL	6840	broad.mit.edu	37	10	29759370	29759370	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:29759370T>C	uc001iut.1	-	32	6431	c.5678A>G	c.(5677-5679)GAA>GGA	p.E1893G	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.E807G|SVIL_uc001iuu.1_Missense_Mutation_p.E1467G	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1893	Gelsolin-like 4.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CAAATTCCCTTCCACGGGCAC	0.617													11	30	---	---	---	---	PASS
PRF1	5551	broad.mit.edu	37	10	72360409	72360409	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:72360409T>G	uc009xqg.2	-	2	411	c.250A>C	c.(250-252)ACC>CCC	p.T84P	PRF1_uc001jrf.3_Missense_Mutation_p.T84P	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	84	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CGCTGGAGGGTGCCCTCCTGT	0.662			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				6	26	---	---	---	---	PASS
SORBS1	10580	broad.mit.edu	37	10	97131754	97131754	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:97131754C>G	uc001kkp.2	-	18	1835	c.1790G>C	c.(1789-1791)AGA>ACA	p.R597T	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Missense_Mutation_p.R199T|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Missense_Mutation_p.R619T|SORBS1_uc001kkq.2_Missense_Mutation_p.R482T|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.R551T|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	597					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TCTATCCTCTCTAGGAAGGAT	0.433													4	7	---	---	---	---	PASS
PNLIPRP2	5408	broad.mit.edu	37	10	118385516	118385516	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:118385516G>A	uc001lcq.2	+	6	290	c.267G>A	c.(265-267)AAG>AAA	p.K89K	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	88					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TGGACCGCAAGACACGCTTCA	0.498													7	13	---	---	---	---	PASS
MTG1	92170	broad.mit.edu	37	10	135233567	135233567	+	Silent	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:135233567A>T	uc001lnd.2	+	11	1007	c.903A>T	c.(901-903)GCA>GCT	p.A301A	MTG1_uc010qve.1_Silent_p.A166A	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	301						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		ATCCTGCGGCAGCCCGTGACT	0.627													23	46	---	---	---	---	PASS
MUC5B	727897	broad.mit.edu	37	11	1157826	1157826	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:1157826G>T	uc009ycr.1	+	9	1019	c.893G>T	c.(892-894)TGT>TTT	p.C298F		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	294					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCTGCTTCTGTGAAGACACC	0.657													15	31	---	---	---	---	PASS
OR51T1	401665	broad.mit.edu	37	11	4903507	4903507	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:4903507G>A	uc010qyp.1	+	1	459	c.459G>A	c.(457-459)GTG>GTA	p.V153V		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCGCTTCGTGGCTATCTGTA	0.478													39	76	---	---	---	---	PASS
MRGPRX1	259249	broad.mit.edu	37	11	18955514	18955514	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:18955514A>G	uc001mpg.2	-	1	1036	c.818T>C	c.(817-819)TTC>TCC	p.F273S		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	273	Helical; Name=7; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GCCCACGAAGAAGTAAATGAT	0.498													12	30	---	---	---	---	PASS
OR4C16	219428	broad.mit.edu	37	11	55339938	55339938	+	Missense_Mutation	SNP	T	A	A	rs143747626		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:55339938T>A	uc010rih.1	+	1	335	c.335T>A	c.(334-336)ATC>AAC	p.I112N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GAGATCTTCATCCTCATCCTC	0.488													36	98	---	---	---	---	PASS
OR4C16	219428	broad.mit.edu	37	11	55339939	55339939	+	Silent	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:55339939C>A	uc010rih.1	+	1	336	c.336C>A	c.(334-336)ATC>ATA	p.I112I		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				AGATCTTCATCCTCATCCTCA	0.493													35	99	---	---	---	---	PASS
OR4P4	81300	broad.mit.edu	37	11	55406540	55406540	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:55406540C>G	uc010rij.1	+	1	707	c.707C>G	c.(706-708)GCC>GGC	p.A236G		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAAGCTCTTGCCACTTGTAGT	0.373													37	16	---	---	---	---	PASS
OR5D18	219438	broad.mit.edu	37	11	55587418	55587418	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:55587418T>A	uc010rin.1	+	1	313	c.313T>A	c.(313-315)TTC>ATC	p.F105I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				ATTCTTTTTCTTCTGTACCTT	0.418													54	127	---	---	---	---	PASS
OR5AR1	219493	broad.mit.edu	37	11	56431579	56431579	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:56431579G>C	uc010rjm.1	+	1	418	c.418G>C	c.(418-420)GTC>CTC	p.V140L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCCAAGCAGGTCTGCTTGGC	0.517													51	97	---	---	---	---	PASS
OR5AR1	219493	broad.mit.edu	37	11	56431588	56431588	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:56431588G>C	uc010rjm.1	+	1	427	c.427G>C	c.(427-429)GCT>CCT	p.A143P		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTCTGCTTGGCTCTCATGCT	0.517													50	93	---	---	---	---	PASS
OR9G4	283189	broad.mit.edu	37	11	56511195	56511195	+	Silent	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:56511195A>T	uc010rjo.1	-	1	93	c.93T>A	c.(91-93)GGT>GGA	p.G31G		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	31	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTGCTGAGAAACCCAACAAGA	0.433													12	49	---	---	---	---	PASS
OR4D10	390197	broad.mit.edu	37	11	59245829	59245829	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:59245829T>G	uc001nnz.1	+	1	927	c.927T>G	c.(925-927)GAT>GAG	p.D309E		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGCCTTCTGATAGAAAATAGA	0.259													8	7	---	---	---	---	PASS
AHNAK	79026	broad.mit.edu	37	11	62286513	62286513	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:62286513A>C	uc001ntl.2	-	5	15676	c.15376T>G	c.(15376-15378)TTG>GTG	p.L5126V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5126					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCGCTGGCAAAGAAAGTTCC	0.493													22	37	---	---	---	---	PASS
SYT12	91683	broad.mit.edu	37	11	66807557	66807557	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:66807557G>T	uc009yrl.2	+	4	734	c.504G>T	c.(502-504)ACG>ACT	p.T168T	SYT12_uc001oju.2_Silent_p.T168T	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	168	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						CCTCCCACACGCTGAACGTGG	0.627													3	30	---	---	---	---	PASS
RNF26	79102	broad.mit.edu	37	11	119206134	119206134	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:119206134G>A	uc001pwh.2	+	1	898	c.302G>A	c.(301-303)GGG>GAG	p.G101E		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	101	Leu-rich.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		AAGCTCCTGGGGCACCTGGCC	0.612													23	66	---	---	---	---	PASS
ROBO3	64221	broad.mit.edu	37	11	124740172	124740172	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:124740172A>T	uc001qbc.2	+	5	1070	c.878A>T	c.(877-879)AAG>ATG	p.K293M		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	293	Ig-like C2-type 3.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CGCTGGCGCAAGGAGGATGGG	0.577													9	17	---	---	---	---	PASS
CHEK1	1111	broad.mit.edu	37	11	125499319	125499319	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:125499319G>T	uc009zbo.2	+	5	1280	c.388G>T	c.(388-390)GAT>TAT	p.D130Y	CHEK1_uc010sbh.1_Missense_Mutation_p.D146Y|CHEK1_uc010sbi.1_Missense_Mutation_p.D130Y|CHEK1_uc001qcf.3_Missense_Mutation_p.D130Y|CHEK1_uc009zbp.2_Missense_Mutation_p.D130Y|CHEK1_uc001qcg.3_Missense_Mutation_p.D130Y|CHEK1_uc009zbq.2_Missense_Mutation_p.D130Y|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	130	Protein kinase.	Proton acceptor.		D->A: Abolishes kinase activity.	cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		AACTCACAGGGATATTAAACC	0.279								Other_conserved_DNA_damage_response_genes					19	22	---	---	---	---	PASS
B4GALNT3	283358	broad.mit.edu	37	12	659049	659049	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:659049G>A	uc001qii.1	+	10	968	c.968G>A	c.(967-969)CGG>CAG	p.R323Q	B4GALNT3_uc001qij.1_Missense_Mutation_p.R225Q|B4GALNT3_uc001qik.1_5'Flank	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	323	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GACATGCTTCGGCCTGACCCC	0.642													7	16	---	---	---	---	PASS
EFCAB4B	84766	broad.mit.edu	37	12	3788200	3788200	+	Silent	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:3788200G>C	uc001qmj.2	-	6	977	c.405C>G	c.(403-405)CGC>CGG	p.R135R	EFCAB4B_uc010sen.1_Silent_p.R135R|EFCAB4B_uc010seo.1_Silent_p.R135R	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	135					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCTCTTCATGGCGCTGGGCCA	0.557													23	89	---	---	---	---	PASS
CD163L1	283316	broad.mit.edu	37	12	7527189	7527189	+	Silent	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:7527189C>T	uc001qsy.2	-	13	3284	c.3258G>A	c.(3256-3258)ACG>ACA	p.T1086T	CD163L1_uc010sge.1_Silent_p.T1096T	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1086	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GAGCAGAGACCGTGGCATTGA	0.617											OREG0021653	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	47	---	---	---	---	PASS
C12orf40	283461	broad.mit.edu	37	12	40076850	40076850	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:40076850A>G	uc001rmc.2	+	8	1291	c.1124A>G	c.(1123-1125)AAG>AGG	p.K375R	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	375										ovary(6)	6						CAGCCAAACAAGAAGTATCAG	0.328													3	24	---	---	---	---	PASS
ADAMTS20	80070	broad.mit.edu	37	12	43822570	43822570	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:43822570G>T	uc010skx.1	-	25	3522	c.3522C>A	c.(3520-3522)GCC>GCA	p.A1174A	ADAMTS20_uc001rno.1_Silent_p.A292A|ADAMTS20_uc001rnp.1_Silent_p.A328A	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1174	TSP type-1 7.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTACATAGCGGGCTTGAGTAC	0.433													25	33	---	---	---	---	PASS
KRT72	140807	broad.mit.edu	37	12	52992868	52992868	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:52992868A>G	uc001sar.2	-	2	541	c.455T>C	c.(454-456)GTG>GCG	p.V152A	KRT72_uc001saq.2_Missense_Mutation_p.V152A|KRT72_uc010sns.1_Missense_Mutation_p.V152A|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	152	Coil 1A.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		GGTCTCTAGCACCTGATTCTG	0.552													21	39	---	---	---	---	PASS
CALCOCO1	57658	broad.mit.edu	37	12	54115397	54115397	+	Silent	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:54115397C>G	uc001sef.2	-	6	756	c.612G>C	c.(610-612)GGG>GGC	p.G204G	CALCOCO1_uc010som.1_Silent_p.G171G|CALCOCO1_uc010son.1_Silent_p.G81G|CALCOCO1_uc001seh.2_Silent_p.G204G|CALCOCO1_uc009znd.2_Silent_p.G204G|CALCOCO1_uc001seg.2_Silent_p.G81G|CALCOCO1_uc010soo.1_Silent_p.G197G	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	204	Potential.				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						ACCGGGAAATCCCCTGAAATT	0.542													88	178	---	---	---	---	PASS
TMTC2	160335	broad.mit.edu	37	12	83526007	83526007	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:83526007A>T	uc001szt.2	+	12	2782	c.2350A>T	c.(2350-2352)AAC>TAC	p.N784Y	TMTC2_uc010suk.1_Missense_Mutation_p.N539Y	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	784	TPR 10.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TGCTTTGATGAACCTGGGAGC	0.493													14	19	---	---	---	---	PASS
HCFC2	29915	broad.mit.edu	37	12	104496843	104496843	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:104496843A>T	uc001tkj.3	+	15	2274	c.2171A>T	c.(2170-2172)AAT>ATT	p.N724I	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	724	Fibronectin type-III 3.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						ATACAAGATAATCCAAGTCAA	0.408													33	63	---	---	---	---	PASS
WDR66	144406	broad.mit.edu	37	12	122395069	122395069	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:122395069G>C	uc009zxk.2	+	11	1767	c.1625G>C	c.(1624-1626)GGC>GCC	p.G542A		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	542							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TTGAAACTGGGCGCCATAAGA	0.423													29	62	---	---	---	---	PASS
ZCCHC8	55596	broad.mit.edu	37	12	122966142	122966142	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:122966142C>G	uc001ucn.2	-	10	1076	c.945G>C	c.(943-945)CAG>CAC	p.Q315H	ZCCHC8_uc001ucm.2_Missense_Mutation_p.Q77H|ZCCHC8_uc009zxp.2_Missense_Mutation_p.Q77H|ZCCHC8_uc009zxq.2_Missense_Mutation_p.Q77H	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	315						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GGTACCCTAGCTGGCGCATCC	0.433													43	72	---	---	---	---	PASS
EIF2B1	1967	broad.mit.edu	37	12	124110982	124110982	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:124110982C>T	uc001ufm.2	-	6	684	c.541G>A	c.(541-543)GCT>ACT	p.A181T	EIF2B1_uc001ufn.2_Missense_Mutation_p.A179T	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	181					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		CCGACAGCAGCATCTAGCACC	0.498													10	18	---	---	---	---	PASS
TMEM132D	121256	broad.mit.edu	37	12	129559299	129559299	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:129559299A>C	uc009zyl.1	-	9	2749	c.2421T>G	c.(2419-2421)AGT>AGG	p.S807R	TMEM132D_uc001uia.2_Missense_Mutation_p.S345R	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	807	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTCTGCTGTCACTGGTGTTGG	0.498													27	69	---	---	---	---	PASS
ZNF10	7556	broad.mit.edu	37	12	133732712	133732712	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr12:133732712G>A	uc009zzb.2	+	5	1327	c.880G>A	c.(880-882)GAG>AAG	p.E294K	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.E294K	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAAACCCTATGAGTGTAAAGA	0.413													22	52	---	---	---	---	PASS
FRY	10129	broad.mit.edu	37	13	32813884	32813884	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr13:32813884C>G	uc001utx.2	+	46	7049	c.6553C>G	c.(6553-6555)CTT>GTT	p.L2185V	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACTTTCAAATCTTGCACATGT	0.373													12	15	---	---	---	---	PASS
N4BP2L2	10443	broad.mit.edu	37	13	33110057	33110057	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr13:33110057C>A	uc001uuk.3	-	2	1286	c.1108G>T	c.(1108-1110)GAA>TAA	p.E370*	N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron|N4BP2L2_uc001uul.1_Nonsense_Mutation_p.E370*|N4BP2L2_uc001uum.2_5'Flank	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	370											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		CAGCATCTTTCTCTGACTTCA	0.388													24	62	---	---	---	---	PASS
C13orf18	80183	broad.mit.edu	37	13	46946524	46946524	+	Silent	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr13:46946524C>A	uc010acl.2	-	3	692	c.87G>T	c.(85-87)TCG>TCT	p.S29S	C13orf18_uc001vbf.3_Intron|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_Intron|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Silent_p.S29S|C13orf18_uc001vbh.3_Silent_p.S29S|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Silent_p.S29S|C13orf18_uc010tga.1_Intron	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	29											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		GGAGTCTGGGCGAACCATCAA	0.522													3	8	---	---	---	---	PASS
INTS6	26512	broad.mit.edu	37	13	52026179	52026179	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr13:52026179C>T	uc001vfk.2	-	2	738	c.124G>A	c.(124-126)GAC>AAC	p.D42N	INTS6_uc001vfj.2_Missense_Mutation_p.D29N|INTS6_uc001vfl.2_5'UTR|INTS6_uc001vfm.2_Missense_Mutation_p.D42N|uc001vfn.2_5'Flank	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	42	VWFA.				snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		CTGGCAGGGTCCCGGGCACGG	0.572													4	14	---	---	---	---	PASS
DACH1	1602	broad.mit.edu	37	13	72053374	72053374	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr13:72053374C>G	uc010thn.1	-	9	2220	c.1797G>C	c.(1795-1797)AAG>AAC	p.K599N	DACH1_uc010tho.1_Missense_Mutation_p.K451N|DACH1_uc010thp.1_Missense_Mutation_p.K397N	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	651	DACHbox-C.|Potential.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AAAAATCCATCTTCAGCTCAG	0.388													37	44	---	---	---	---	PASS
POTEG	404785	broad.mit.edu	37	14	19553590	19553590	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr14:19553590G>T	uc001vuz.1	+	1	226	c.174G>T	c.(172-174)AGG>AGT	p.R58S	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	58										ovary(1)	1						AGACACTCAGGAGCAAGATGG	0.612													33	232	---	---	---	---	PASS
RNASE10	338879	broad.mit.edu	37	14	20979274	20979274	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr14:20979274G>T	uc010tlj.1	+	1	644	c.644G>T	c.(643-645)GGA>GTA	p.G215V	RNASE10_uc001vxp.2_Missense_Mutation_p.G243V	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	215						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		TTACCAACTGGACAATGAAGC	0.249													8	6	---	---	---	---	PASS
MIA2	117153	broad.mit.edu	37	14	39722083	39722083	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr14:39722083G>A	uc001wux.2	+	5	1893	c.1699G>A	c.(1699-1701)GAC>AAC	p.D567N		NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	Error:Variant_position_missing_in_Q96PC5_after_alignment						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GGTGGAGATAGACAGATCTGT	0.373													17	17	---	---	---	---	PASS
NIN	51199	broad.mit.edu	37	14	51190336	51190336	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr14:51190336C>T	uc001wyi.2	-	31	6438	c.6247G>A	c.(6247-6249)GCC>ACC	p.A2083T	NIN_uc001wyj.2_RNA	NM_020921	NP_065972	Q8N4C6	NIN_HUMAN	ninein isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AACAACTGGGCATTTTCAACA	0.428			T	PDGFRB	MPD								23	16	---	---	---	---	PASS
NIPA2	81614	broad.mit.edu	37	15	23006622	23006622	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr15:23006622A>G	uc001yux.2	-	8	1295	c.682T>C	c.(682-684)TGT>CGT	p.C228R	NIPA2_uc001yuy.2_Missense_Mutation_p.C228R|NIPA2_uc001yuz.2_Missense_Mutation_p.C228R|NIPA2_uc001yva.2_Missense_Mutation_p.C209R|NIPA2_uc001yvb.2_Missense_Mutation_p.C228R|NIPA2_uc010ayb.2_Missense_Mutation_p.C209R	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	228	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		GTGCTCACACAGACGATGAGG	0.463													44	32	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	33835852	33835852	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr15:33835852C>G	uc001zhi.2	+	8	746	c.676C>G	c.(676-678)CTT>GTT	p.L226V	RYR3_uc010bar.2_Missense_Mutation_p.L226V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	226	MIR 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGTAGTACGTCTTTTCCATGG	0.398													55	34	---	---	---	---	PASS
PGBD4	161779	broad.mit.edu	37	15	34396179	34396179	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr15:34396179A>G	uc001zho.2	+	1	1906	c.1447A>G	c.(1447-1449)ATA>GTA	p.I483V	C15orf24_uc001zhm.2_5'Flank|C15orf24_uc001zhn.2_5'Flank	NM_152595	NP_689808	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	483											0		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		GATGAGCCATATAAACTTCAG	0.443													15	4	---	---	---	---	PASS
ATPBD4	89978	broad.mit.edu	37	15	35703036	35703036	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr15:35703036C>G	uc001zja.2	-	6	629	c.567G>C	c.(565-567)GAG>GAC	p.E189D	ATPBD4_uc001ziz.2_Missense_Mutation_p.E173D	NM_080650	NP_542381	Q7L8W6	ATBD4_HUMAN	ATP binding domain 4 isoform 1	189											0		all_epithelial(112;2.11e-09)|Lung NSC(122;2.38e-08)|all_lung(180;3.65e-07)		all cancers(64;9.9e-19)|GBM - Glioblastoma multiforme(113;2.01e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		AAATTCTTACCTCTATGAGAT	0.294													43	43	---	---	---	---	PASS
AKAP13	11214	broad.mit.edu	37	15	86213042	86213042	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr15:86213042C>G	uc002blv.1	+	14	5252	c.5082C>G	c.(5080-5082)ATC>ATG	p.I1694M	AKAP13_uc002blt.1_Missense_Mutation_p.I1676M|AKAP13_uc002blu.1_Missense_Mutation_p.I1698M|AKAP13_uc010bnf.1_Missense_Mutation_p.I316M|AKAP13_uc002blw.1_Missense_Mutation_p.I161M|AKAP13_uc010bne.1_Missense_Mutation_p.I347M	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1694					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TAATGACAATCAGCCATCCTG	0.338													18	15	---	---	---	---	PASS
ACSM2B	348158	broad.mit.edu	37	16	20576154	20576154	+	Missense_Mutation	SNP	C	T	T	rs144570025		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr16:20576154C>T	uc002dhj.3	-	3	224	c.14G>A	c.(13-15)CGA>CAA	p.R5Q	ACSM2B_uc002dhk.3_Missense_Mutation_p.R5Q|ACSM2B_uc010bwf.1_Missense_Mutation_p.R5Q	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	5					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CTGAACTTTTCGCAGCCAATG	0.498													4	28	---	---	---	---	PASS
CYLD	1540	broad.mit.edu	37	16	50826618	50826618	+	Splice_Site	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr16:50826618T>A	uc002egp.1	+	16	2765	c.2350_splice	c.e16+2	p.T784_splice	CYLD_uc010cbs.1_Splice_Site_p.T781_splice|CYLD_uc002egq.1_Splice_Site_p.T781_splice|CYLD_uc002egr.1_Splice_Site_p.T781_splice	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD						cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TTGAAGACAGTAAGTATGAGA	0.209			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				4	9	---	---	---	---	PASS
COQ9	57017	broad.mit.edu	37	16	57486804	57486804	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr16:57486804C>T	uc002elq.2	+	3	350	c.334C>T	c.(334-336)CCC>TCC	p.P112S	COQ9_uc002elp.1_Missense_Mutation_p.P112S|COQ9_uc010vhn.1_Missense_Mutation_p.P112S|COQ9_uc010vho.1_Missense_Mutation_p.P112S|COQ9_uc010vhp.1_Missense_Mutation_p.P112S|COQ9_uc002elr.2_Missense_Mutation_p.P112S	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	112					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						TGAGTTTGTGCCCGCCCACGG	0.592													3	40	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7579358	7579358	+	Missense_Mutation	SNP	C	A	A	rs11540654		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:7579358C>A	uc002gim.2	-	4	523	c.329G>T	c.(328-330)CGT>CTT	p.R110L	TP53_uc002gig.1_Missense_Mutation_p.R110L|TP53_uc002gih.2_Missense_Mutation_p.R110L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.R110L|TP53_uc010cni.1_Missense_Mutation_p.R110L|TP53_uc002gij.2_Missense_Mutation_p.R110L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.R71L|TP53_uc010cnk.1_Missense_Mutation_p.R125L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		R -> G (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	16	---	---	---	---	PASS
CCDC42	146849	broad.mit.edu	37	17	8638528	8638528	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:8638528G>T	uc002gln.2	-	6	986	c.759C>A	c.(757-759)ACC>ACA	p.T253T	CCDC42_uc002glo.2_Silent_p.T179T	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	253										ovary(1)	1						CAAGCAGGAGGGTCTTCTTGG	0.522													11	10	---	---	---	---	PASS
FZD2	2535	broad.mit.edu	37	17	42635359	42635359	+	Silent	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:42635359C>A	uc002igx.1	+	1	435	c.303C>A	c.(301-303)ACC>ACA	p.T101T		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	101	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCGTGTGCACCGTGCTGGAAC	0.632													25	52	---	---	---	---	PASS
DBF4B	80174	broad.mit.edu	37	17	42809611	42809611	+	Silent	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:42809611A>G	uc002ihf.2	+	6	747	c.534A>G	c.(532-534)GGA>GGG	p.G178G	DBF4B_uc002ihd.1_3'UTR|DBF4B_uc010wjb.1_Intron|DBF4B_uc002ihe.2_Intron|DBF4B_uc010wjc.1_Silent_p.G162G|DBF4B_uc002ihg.2_3'UTR	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	178					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				GCTCTTGGGGAGTGAGGATTC	0.552													10	18	---	---	---	---	PASS
MPO	4353	broad.mit.edu	37	17	56349033	56349033	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:56349033C>A	uc002ivu.1	-	11	2190	c.2013G>T	c.(2011-2013)AAG>AAT	p.K671N		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	671					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CATCCCGGAGCTTCCTGAACT	0.632													13	13	---	---	---	---	PASS
BPTF	2186	broad.mit.edu	37	17	65924580	65924580	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:65924580T>G	uc002jgf.2	+	16	5922	c.5861T>G	c.(5860-5862)ATA>AGA	p.I1954R	BPTF_uc002jge.2_Missense_Mutation_p.I2080R	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2080					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTGGCCCCCATAAGTGGCTCA	0.458													5	32	---	---	---	---	PASS
ITGB4	3691	broad.mit.edu	37	17	73727361	73727361	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:73727361A>G	uc002jpg.2	+	10	1314	c.1127A>G	c.(1126-1128)GAC>GGC	p.D376G	ITGB4_uc002jph.2_Missense_Mutation_p.D376G|ITGB4_uc010dgo.2_Missense_Mutation_p.D376G|ITGB4_uc002jpi.3_Missense_Mutation_p.D376G|ITGB4_uc010dgp.1_Missense_Mutation_p.D376G|ITGB4_uc002jpj.2_Missense_Mutation_p.D376G|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	376	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGGCCCTAGACAGCCCCCGA	0.617													14	24	---	---	---	---	PASS
WDR45L	56270	broad.mit.edu	37	17	80588802	80588802	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:80588802T>A	uc002kfq.2	-	3	434	c.239A>T	c.(238-240)AAC>ATC	p.N80I	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	80					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			AGTACCTTTGTTGGGAGGGTA	0.408													66	116	---	---	---	---	PASS
LAMA1	284217	broad.mit.edu	37	18	6971894	6971894	+	Silent	SNP	A	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:6971894A>G	uc002knm.2	-	48	6955	c.6861T>C	c.(6859-6861)TAT>TAC	p.Y2287Y	LAMA1_uc010wzj.1_Silent_p.Y1763Y	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2287	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTTTCAATATAGTTCCATA	0.443													37	42	---	---	---	---	PASS
LAMA1	284217	broad.mit.edu	37	18	6971974	6971974	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:6971974G>C	uc002knm.2	-	48	6875	c.6781C>G	c.(6781-6783)CCT>GCT	p.P2261A	LAMA1_uc010wzj.1_Missense_Mutation_p.P1737A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2261	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCACAGCAGGAGATTTCTAA	0.413													10	44	---	---	---	---	PASS
LAMA1	284217	broad.mit.edu	37	18	6997882	6997882	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:6997882G>T	uc002knm.2	-	33	4759	c.4665C>A	c.(4663-4665)TCC>TCA	p.S1555S	LAMA1_uc010wzj.1_Silent_p.S1031S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1555	Laminin EGF-like 17.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CATCATCACAGGCTACAAGAC	0.418													21	49	---	---	---	---	PASS
LAMA3	3909	broad.mit.edu	37	18	21399941	21399941	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:21399941G>A	uc002kuq.2	+	19	2370	c.2284G>A	c.(2284-2286)GCC>ACC	p.A762T	LAMA3_uc002kur.2_Missense_Mutation_p.A762T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	762					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGAGGATATGCCCAAATGAC	0.502													6	18	---	---	---	---	PASS
RIT2	6014	broad.mit.edu	37	18	40323598	40323598	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:40323598C>A	uc002lav.2	-	5	687	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	172					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						TGAAAAGCATCATCAATACAG	0.418													18	63	---	---	---	---	PASS
CDH19	28513	broad.mit.edu	37	18	64172254	64172254	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:64172254T>C	uc002lkc.1	-	12	2252	c.2114A>G	c.(2113-2115)GAA>GGA	p.E705G	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	705	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				AGTATTAGCTTCTTCGAGCTT	0.488													41	57	---	---	---	---	PASS
SOCS6	9306	broad.mit.edu	37	18	67992174	67992174	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:67992174G>T	uc002lkr.1	+	2	586	c.270G>T	c.(268-270)AAG>AAT	p.K90N	SOCS6_uc010dqq.2_Missense_Mutation_p.K90N	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	90					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CAAAAGGCAAGGCGGGCACAC	0.517													14	27	---	---	---	---	PASS
ATP9B	374868	broad.mit.edu	37	18	77119463	77119463	+	Splice_Site	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr18:77119463G>T	uc002lmx.2	+	26	3026	c.3012_splice	c.e26+1	p.K1004_splice	ATP9B_uc002lmw.1_Splice_Site_p.K1004_splice|ATP9B_uc002lmz.1_Missense_Mutation_p.V699L|ATP9B_uc002lna.2_Splice_Site_p.K30_splice|ATP9B_uc002lnb.1_Splice_Site_p.G103_splice|ATP9B_uc010drb.2_Splice_Site	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B						ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CCTCACCAAGGTACGGGCCTC	0.537													5	13	---	---	---	---	PASS
FEM1A	55527	broad.mit.edu	37	19	4792420	4792420	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:4792420C>A	uc002mbf.2	+	1	693	c.554C>A	c.(553-555)ACG>AAG	p.T185K	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	185	ANK 6.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		AAGGGCAACACGGCCCTGCAT	0.677													4	18	---	---	---	---	PASS
TNFSF14	8740	broad.mit.edu	37	19	6665114	6665114	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:6665114G>T	uc002mfk.1	-	5	928	c.546C>A	c.(544-546)AGC>AGA	p.S182R	TNFSF14_uc002mfj.1_Missense_Mutation_p.S146R	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	182	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						GTGACTGCTGGCTGACCAACA	0.692													18	31	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9074571	9074571	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:9074571C>T	uc002mkp.2	-	3	13079	c.12875G>A	c.(12874-12876)GGC>GAC	p.G4292D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4294	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCGGAGGAGCCAAATACTGA	0.517													10	23	---	---	---	---	PASS
PRKCSH	5589	broad.mit.edu	37	19	11559430	11559430	+	Silent	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:11559430G>A	uc002mrt.2	+	14	1587	c.1251G>A	c.(1249-1251)GAG>GAA	p.E417E	PRKCSH_uc002mru.2_Silent_p.E414E|PRKCSH_uc010xlz.1_Silent_p.E424E|PRKCSH_uc010dya.2_Silent_p.E199E|PRKCSH_uc010dyb.2_Silent_p.E414E	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	417	PRKCSH.				innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						AGTGCTACGAGCTCACCACCA	0.612													19	37	---	---	---	---	PASS
ZNF91	7644	broad.mit.edu	37	19	23578143	23578143	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:23578143G>T	uc002nre.2	-	1	127	c.14C>A	c.(13-15)CCT>CAT	p.P5H	ZNF91_uc010xrj.1_Missense_Mutation_p.P5H	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	5						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TAGGCTTCCAGGGGTTCCTGG	0.622													12	45	---	---	---	---	PASS
ZNF146	7705	broad.mit.edu	37	19	36727458	36727458	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:36727458C>G	uc002odq.3	+	4	1639	c.116C>G	c.(115-117)ACG>AGG	p.T39R	ZNF146_uc010eet.2_Missense_Mutation_p.T39R|ZNF146_uc010eeu.2_Missense_Mutation_p.T39R	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	39					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					CATTTTCACACGAGAGAGAAA	0.428													15	54	---	---	---	---	PASS
PSG1	5669	broad.mit.edu	37	19	43382112	43382112	+	Missense_Mutation	SNP	T	A	A	rs1058668	byFrequency	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:43382112T>A	uc002ovb.2	-	2	521	c.383A>T	c.(382-384)GAT>GTT	p.D128V	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.D128V|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.D128V|PSG1_uc010eio.1_Missense_Mutation_p.D128V|PSG1_uc002oux.1_Missense_Mutation_p.D57V|PSG1_uc002ouy.1_Missense_Mutation_p.D128V|PSG1_uc002ouz.1_Missense_Mutation_p.D128V|PSG1_uc002ova.1_Missense_Mutation_p.D128V|PSG1_uc002ovc.2_Missense_Mutation_p.D128V|PSG1_uc002ovd.1_Missense_Mutation_p.D128V	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	128	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AGTCCCATCATCTCCCTTTAT	0.498													61	161	---	---	---	---	PASS
ZNF221	7638	broad.mit.edu	37	19	44469153	44469153	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:44469153G>T	uc002oxx.2	+	4	461	c.133G>T	c.(133-135)GGG>TGG	p.G45W	ZNF221_uc010ejb.1_Missense_Mutation_p.G45W|ZNF221_uc010xws.1_Missense_Mutation_p.G45W	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				GGAGGAGCTGGGGCTGCTGGA	0.488													47	91	---	---	---	---	PASS
NLRP4	147945	broad.mit.edu	37	19	56369053	56369053	+	Silent	SNP	C	A	A	rs149802462		TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr19:56369053C>A	uc002qmd.3	+	3	716	c.294C>A	c.(292-294)ACC>ACA	p.T98T	NLRP4_uc002qmf.2_Silent_p.T23T|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	98							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACACAAAGACCTATCAAGCTC	0.418													13	34	---	---	---	---	PASS
CD93	22918	broad.mit.edu	37	20	23065078	23065078	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr20:23065078G>T	uc002wsv.2	-	1	1900	c.1752C>A	c.(1750-1752)TTC>TTA	p.F584L		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	584	Helical; (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTAGGATGTAGAATAAAAGCA	0.607													32	96	---	---	---	---	PASS
ACSS2	55902	broad.mit.edu	37	20	33508829	33508829	+	Silent	SNP	T	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr20:33508829T>C	uc002xbd.2	+	10	1285	c.1164T>C	c.(1162-1164)TAT>TAC	p.Y388Y	ACSS2_uc002xbc.2_Silent_p.Y293Y|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Silent_p.Y401Y|ACSS2_uc002xbe.2_Silent_p.Y96Y|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	388					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TTCCCACATATCCGGACGTGA	0.502													55	103	---	---	---	---	PASS
TRPC4AP	26133	broad.mit.edu	37	20	33657206	33657206	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr20:33657206G>A	uc002xbk.2	-	3	341	c.307C>T	c.(307-309)CCT>TCT	p.P103S	TRPC4AP_uc002xbl.2_Missense_Mutation_p.P103S|TRPC4AP_uc010zur.1_Intron|TRPC4AP_uc002xbm.1_Missense_Mutation_p.P103S	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	103	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GAGAGAAGAGGAGAAATTTCC	0.368													12	28	---	---	---	---	PASS
TOX2	84969	broad.mit.edu	37	20	42694617	42694617	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr20:42694617C>A	uc002xlf.3	+	6	1189	c.1172C>A	c.(1171-1173)CCC>CAC	p.P391H	TOX2_uc010ggo.2_Missense_Mutation_p.P409H|TOX2_uc002xle.3_Missense_Mutation_p.P367H|TOX2_uc010ggp.2_Missense_Mutation_p.P367H|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Missense_Mutation_p.P287H	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	391	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTGTCACTGCCCCCTCACGCC	0.706													8	15	---	---	---	---	PASS
PPP1R3D	5509	broad.mit.edu	37	20	58514346	58514346	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr20:58514346C>T	uc002ybb.2	-	1	1007	c.641G>A	c.(640-642)CGC>CAC	p.R214H	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	214	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			GTGGGTACTGCGCCAGCCCGA	0.672													3	34	---	---	---	---	PASS
TAB3	257397	broad.mit.edu	37	X	30873661	30873661	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chrX:30873661C>T	uc004dcj.2	-	6	784	c.121G>A	c.(121-123)GCC>ACC	p.A41T	TAB3_uc004dck.2_Missense_Mutation_p.A41T|TAB3_uc010ngl.2_Missense_Mutation_p.A41T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	41	CUE.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						CGGCAACAGGCTTCAAGATTG	0.373													8	21	---	---	---	---	PASS
ZMYM3	9203	broad.mit.edu	37	X	70466473	70466473	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chrX:70466473G>C	uc004dzh.1	-	14	2471	c.2384C>G	c.(2383-2385)ACC>AGC	p.T795S	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.T795S|ZMYM3_uc004dzj.1_Intron	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	795					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TTCCTCTGGGGTCCTCACTGT	0.507													10	6	---	---	---	---	PASS
TEX13A	56157	broad.mit.edu	37	X	104464700	104464700	+	Silent	SNP	G	T	T			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chrX:104464700G>T	uc004ema.2	-	2	494	c.382C>A	c.(382-384)CGG>AGG	p.R128R	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Silent_p.R128R	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	128						intracellular	zinc ion binding			ovary(2)	2						ATTCTTAGCCGGGAGGCCGCC	0.592													21	14	---	---	---	---	PASS
WRNIP1	56897	broad.mit.edu	37	6	2766468	2766469	+	Frame_Shift_Ins	INS	-	G	G	rs148900120	by1000genomes	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr6:2766468_2766469insG	uc003mtz.2	+	1	803_804	c.612_613insG	c.(610-615)GGCGGGfs	p.G204fs	WRNIP1_uc003mua.2_Frame_Shift_Ins_p.G204fs	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	204_205					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GGGCCAGTggcgggggccgccc	0.465													4	2	---	---	---	---	
ST8SIA6	338596	broad.mit.edu	37	10	17365142	17365142	+	Frame_Shift_Del	DEL	G	-	-			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr10:17365142delG	uc001ipd.2	-	7	650	c.650delC	c.(649-651)CCAfs	p.P217fs	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	217	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						TCCTGTGGTTGGGGGTAGGTT	0.279													56	30	---	---	---	---	
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651228	+	In_Frame_Del	DEL	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	-	-	rs144216147	by1000genomes	TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr11:1651199_1651228delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	uc001lty.2	+	1	167_196	c.129_158delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	c.(127-159)GGAGGCTGTGGGGGCTGTGGCTCCGGCTGTGCG>GGG	p.GCGGCGSGCA44del		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	44_53				A -> G (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtgggggctgtggctccggctgtgcgggctgtggg	0.187													26	13	---	---	---	---	
SLC6A4	6532	broad.mit.edu	37	17	28545947	28545947	+	Frame_Shift_Del	DEL	C	-	-			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chr17:28545947delC	uc002hey.3	-	4	890	c.346delG	c.(346-348)GCAfs	p.A116fs		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	116	Helical; Name=2; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AGGAGGAATGCCCCTGAGGCA	0.527													43	19	---	---	---	---	
TGIF2LX	90316	broad.mit.edu	37	X	89177283	89177283	+	Frame_Shift_Del	DEL	G	-	-			TCGA-22-5480-01A-01D-1632-08	TCGA-22-5480-11A-01D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	24e426fb-219a-4a4d-a45c-c9b0896d0e88	77dda1a1-3c2e-488d-9cd0-da78dba549ec	g.chrX:89177283delG	uc004efe.2	+	2	248	c.199delG	c.(199-201)GACfs	p.D67fs		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	67	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GATCCTCCGCGACTGGATGTA	0.468													37	34	---	---	---	---