Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIR3DL3	115653	broad.mit.edu	37	19	55247442	55247442	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:55247442C>G	ENST00000291860.1	+	8	1130	c.1112C>G	c.(1111-1113)tCt>tGt	p.S371C	CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron	NM_153443.3	NP_703144.2	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	371						integral to membrane|plasma membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(3)|prostate(1)|skin(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		CTCCAGGACTCTGATGAACAA	0.537000													4	155					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24655922	24655922	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr14:24655922T>C	ENST00000354464.6	-	9	1008	c.832A>G	c.(832-834)Aag>Gag	p.K278E	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	278					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		ACCTTGCTCTTGACTTTGACC	0.493000													31	30					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29553521	29553521	+	Silent	SNP	C	C	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr17:29553521C>G	ENST00000358273.4	+	18	2453	c.2070C>G	c.(2068-2070)gcC>gcG	p.A690A	NF1_ENST00000356175.3_Silent_p.A690A	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	690					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TAGAAGTGGCCCTGTACATGT	0.542000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	115					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29654675	29654675	+	Silent	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr17:29654675G>A	ENST00000358273.4	+	38	5810	c.5427G>A	c.(5425-5427)ccG>ccA	p.P1809P	NF1_ENST00000581113.2_3'UTR|NF1_ENST00000356175.3_Silent_p.P1788P	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1809					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGGGCACGCCGCTCACCTTCA	0.478000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	179					0	0	1	0	0
HERC2P9	0	broad.mit.edu	37	15	28900818	28900818	+	RNA	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr15:28900818C>T	ENST00000528584.1	+	0	162					NR_036443.1																						CACAGCTTTGCGGGAAGGCCT	0.547000													4	127					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11022906	11022906	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:11022906C>T	ENST00000327064.4	+	5	795	c.605C>T	c.(604-606)gCc>gTc	p.A202V	CARM1_ENST00000344150.4_Missense_Mutation_p.A202V	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	202					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding	p.A202V(2)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						TCGTTTTTTGCCGCCCAAGCT	0.622000													5	454					0	0	1	0	0
C5orf49	134121	broad.mit.edu	37	5	7835522	7835522	+	Missense_Mutation	SNP	T	T	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr5:7835522T>G	ENST00000399810.2	-	2	705	c.237A>C	c.(235-237)aaA>aaC	p.K79N	C5orf49_ENST00000509627.1_Missense_Mutation_p.K79N	NM_001089584.2	NP_001083053.1	A4QMS7	CE049_HUMAN	chromosome 5 open reading frame 49	79										large_intestine(3)|lung(5)|skin(1)	9						GTCCCAGGCTTTTTGCATGTT	0.338000													77	162					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101294550	101294550	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr13:101294550G>A	ENST00000342624.5	-	7	914	c.656C>T	c.(655-657)gCg>gTg	p.A219V	TMTC4_ENST00000376234.3_Missense_Mutation_p.A200V|TMTC4_ENST00000462211.1_5'UTR|TMTC4_ENST00000328767.5_Missense_Mutation_p.A89V	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	200						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGAAGAATGCGCTCCCTCCTT	0.468000													68	106					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138879424	138879424	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chrX:138879424T>C	ENST00000370557.1	-	11	1946	c.919A>G	c.(919-921)Act>Gct	p.T307A	ATP11C_ENST00000359686.2_Missense_Mutation_p.T310A|ATP11C_ENST00000327569.3_Missense_Mutation_p.T310A|ATP11C_ENST00000370543.1_Missense_Mutation_p.T310A|ATP11C_ENST00000361648.2_Missense_Mutation_p.T310A|ATP11C_ENST00000460773.1_5'UTR			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	310					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TTTAGAGTAGTGCATACTGCA	0.338000													89	139					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135535	156135535	+	Silent	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr4:156135535G>A	ENST00000329476.3	+	2	933	c.444G>A	c.(442-444)cgG>cgA	p.R148R	NPY2R_ENST00000506608.1_Silent_p.R148R	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	148					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CCCTGGACCGGCACAGGTGCA	0.557000													4	91					0	0	1	0	0
CTC-457E21.3	0	broad.mit.edu	37	19	22780167	22780167	+	RNA	SNP	A	A	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:22780167A>G	ENST00000600260.1	+	0	245					NR_033899.1																						TAACCCCGAGACAACCACTTC	0.512000													35	58					0	0	1	0	0
TVP23C	201158	broad.mit.edu	37	17	15441469	15441469	+	Splice_Site	SNP	C	C	T	rs139351610	by1000genomes	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr17:15441469C>T	ENST00000584811.1	-	7	1815		c.e7-2		TVP23C_ENST00000438826.3_Splice_Site|TVP23C_ENST00000428082.2_Splice_Site|TVP23C_ENST00000519970.1_Intron|TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000225576.3_Intron					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		TCCAGTGTTCCGCAAAAGACA	0.393000													6	137					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684008	113684008	+	Silent	SNP	G	G	A	rs145304274	byFrequency	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr3:113684008G>A	ENST00000295878.3	-	17	2951	c.2805C>T	c.(2803-2805)aaC>aaT	p.N935N		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	935										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						TGGCTCATTCGTTCACCAGAC	0.438000													12	123					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24300025	24300025	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr8:24300025G>A	ENST00000175238.6	+	2	175	c.92G>A	c.(91-93)cGt>cAt	p.R31H	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.R31H|ADAM7_ENST00000441335.2_Missense_Mutation_p.R31H	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	31					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAACTGGTTCGTCCTAAAAAG	0.403000													6	349					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141754687	141754687	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr7:141754687G>A	ENST00000475668.2	+	27	3347	c.3293G>A	c.(3292-3294)cGg>cAg	p.R1098Q	MGAM_ENST00000549489.2_Missense_Mutation_p.R1098Q			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1098	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.R1098Q(1)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAAATTCGCCGGAAGAGTACA	0.502000													4	167					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17277216	17277216	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr10:17277216G>A	ENST00000544301.1	+	7	1470	c.1057G>A	c.(1057-1059)Gtt>Att	p.V353I	VIM_ENST00000224237.5_Missense_Mutation_p.V353I	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	353	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GAACTTTGCCGTTGAAGCTGC	0.483000													4	135					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791853	42791853	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:42791853C>T	ENST00000572681.2	+	6	3534	c.3466C>T	c.(3466-3468)Cag>Tag	p.Q1156*	CIC_ENST00000160740.3_Nonsense_Mutation_p.Q247*|CIC_ENST00000575354.2_Nonsense_Mutation_p.Q247*			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	247	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAAGGAGAAGCAGAAGTACCA	0.632000			"""Mis, F, S"""		oligodendroglioma								5	76					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													7	184					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68456652	68456652	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr4:68456652C>A	ENST00000265404.2	+	7	792	c.710C>A	c.(709-711)aCt>aAt	p.T237N	STAP1_ENST00000396225.1_Missense_Mutation_p.T237N	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	237	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						CAAAACTACACTATTGAACTG	0.373000													8	112					5.68852e-11	6.14728e-11	1	1	0
CETN2	1069	broad.mit.edu	37	X	151997187	151997187	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chrX:151997187T>C	ENST00000370277.3	-	4	389	c.323A>G	c.(322-324)aAa>aGa	p.K108R	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	108	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTTGAAAGCTTTCAGGATTTC	0.433000								Direct reversal of damage;Nucleotide excision repair (NER)					58	95					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								5	283					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								65	119					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19338812	19338812	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:19338812C>T	ENST00000252575.5	+	8	2426	c.2383C>T	c.(2383-2385)Cca>Tca	p.P795S	NCAN_ENST00000538881.1_Missense_Mutation_p.P246S	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	795					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TGCAAGTTCCCCATCTGCCCC	0.577000													4	148					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321614	52321614	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr8:52321614G>A	ENST00000356297.4	-	17	2670	c.2570C>T	c.(2569-2571)gCg>gTg	p.A857V	PXDNL_ENST00000543296.1_Missense_Mutation_p.A857V	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	857					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATGCAGGGCGCGTGGGTGCC	0.682000													8	74					0	0	1	0	0
HSPA9	3313	broad.mit.edu	37	5	137895665	137895665	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr5:137895665G>A	ENST00000297185.3	-	11	1423	c.1298C>T	c.(1297-1299)aCg>aTg	p.T433M	HSPA9_ENST00000501917.2_Intron	NM_004134.6	NP_004125.3	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 (mortalin)	433					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CAGCACATCCGTGACATCGCC	0.498000													7	73					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													5	22					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47303193	47303193	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr11:47303193A>G	ENST00000342922.4	+	8	1715	c.1358A>G	c.(1357-1359)gAg>gGg	p.E453G	MADD_ENST00000489415.1_3'UTR|MADD_ENST00000407859.3_Missense_Mutation_p.E453G|MADD_ENST00000406482.1_Missense_Mutation_p.E453G|MADD_ENST00000402799.1_Missense_Mutation_p.E453G|MADD_ENST00000402192.2_Missense_Mutation_p.E453G|MADD_ENST00000395336.3_Missense_Mutation_p.E453G|MADD_ENST00000395344.3_Missense_Mutation_p.E453G|MADD_ENST00000349238.3_Missense_Mutation_p.E453G|MADD_ENST00000311027.5_Missense_Mutation_p.E453G	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	453					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GAGGGCCAGGAGATCCCCCTT	0.498000													9	114					0	0	1	0	0
UTP14A	10813	broad.mit.edu	37	X	129042694	129042694	+	Silent	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chrX:129042694C>T	ENST00000394422.3	+	4	250	c.222C>T	c.(220-222)ttC>ttT	p.F74F	RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Silent_p.F74F|UTP14A_ENST00000371051.5_Intron	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	74					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						TGTCAGAGTTCAATGTCAGTT	0.443000													24	550					0	0	1	0	0
TRIM51HP	0	broad.mit.edu	37	11	55065705	55065705	+	RNA	SNP	G	G	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr11:55065705G>A	ENST00000526016.1	-	0	3					NR_038174.2																						GATGGGACAGGTGAGTTCCCT	0.483000													4	157					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29553550	29553550	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr17:29553550C>G	ENST00000358273.4	+	18	2482	c.2099C>G	c.(2098-2100)aCt>aGt	p.T700S	NF1_ENST00000356175.3_Missense_Mutation_p.T700S	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	700					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)|p.T700S(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AACCCTGACACTGAAGCTGTT	0.552000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			5	144					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29786175	29786175	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr12:29786175G>T	ENST00000256062.5	-	6	1182	c.709C>A	c.(709-711)Ctg>Atg	p.L237M	TMTC1_ENST00000552618.1_Missense_Mutation_p.L407M|TMTC1_ENST00000539277.1_Missense_Mutation_p.L345M|TMTC1_ENST00000381224.2_Missense_Mutation_p.L299M|TMTC1_ENST00000551659.1_Missense_Mutation_p.L407M|TMTC1_ENST00000319685.8_5'UTR	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	345						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GTCTCTACCAGAGGAATACTG	0.502000													42	69					1.57019e-19	1.72464e-19	1	1	0
CCDC135	84229	broad.mit.edu	37	16	57760786	57760786	+	Missense_Mutation	SNP	G	G	A	rs141535311		TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr16:57760786G>A	ENST00000360716.3	+	15	2238	c.2017G>A	c.(2017-2019)Gag>Aag	p.E673K	CCDC135_ENST00000336825.8_Missense_Mutation_p.E608K|CCDC135_ENST00000394337.4_Missense_Mutation_p.E673K			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	673						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CTACCAGTACGAGGCCATGAT	0.582000													17	34					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													7	166					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168471	25168471	+	RNA	SNP	C	C	T	rs61946941	by1000genomes	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr13:25168471C>T	ENST00000453498.1	+	0	1143																											CATCTCTGTACGATGATGTGA	0.358000													4	80					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611166	179611166	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr2:179611166C>T	ENST00000360870.5	-	46	16183	c.15961G>A	c.(15961-15963)Gtt>Att	p.V5321I	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8833	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCTTTAACGTCTTTTTCA	0.363000													6	101					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000492078.1_5'UTR|TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													3	32					0	0	1	0	0
LGALS1	3956	broad.mit.edu	37	22	38073059	38073059	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr22:38073059C>T	ENST00000215909.5	+	2	171	c.76C>T	c.(76-78)Cct>Tct	p.P26S	LGALS1_ENST00000489315.1_3'UTR	NM_002305.3	NP_002296.1	P09382	LEG1_HUMAN	lectin, galactoside-binding, soluble, 1	26	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity			endometrium(1)|large_intestine(1)|lung(1)	3	Melanoma(58;0.0574)					CGAGGTGGCTCCTGACGCTAA	0.657000													24	37					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90283584	90283584	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr9:90283584C>T	ENST00000469640.2	+	19	2371	c.1996C>T	c.(1996-1998)Cga>Tga	p.R666*	DAPK1_ENST00000491893.1_Nonsense_Mutation_p.R666*|DAPK1_ENST00000408954.3_Nonsense_Mutation_p.R666*|DAPK1_ENST00000466188.1_3'UTR|DAPK1_ENST00000358077.5_Nonsense_Mutation_p.R666*|DAPK1_ENST00000472284.1_Nonsense_Mutation_p.R666*			P53355	DAPK1_HUMAN	death-associated protein kinase 1	666					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TGCAAGACTTCGAAAGGTGAG	0.423000									Chronic Lymphocytic Leukemia, Familial Clustering of				23	270					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69167987	69167987	+	Missense_Mutation	SNP	C	C	T	rs149196259	by1000genomes	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr3:69167987C>T	ENST00000420581.2	-	2	1698	c.1519G>A	c.(1519-1521)Gag>Aag	p.E507K	LMOD3_ENST00000489031.1_Missense_Mutation_p.E507K|LMOD3_ENST00000475434.1_Missense_Mutation_p.E507K	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	507						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		TTGGTTTTCTCGGGTGGTTCT	0.547000													32	37					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3129656	3129656	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr20:3129656C>A	ENST00000380266.3	-	2	382	c.61G>T	c.(61-63)Gcc>Tcc	p.A21S	UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	21					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						GCACCAAAGGCAGAAGGACTG	0.478000													4	162					0.150653	0.150653	1	1	0
ZDHHC24	254359	broad.mit.edu	37	11	66307297	66307297	+	Splice_Site	SNP	T	T	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr11:66307297T>C	ENST00000310442.3	-	3	794		c.e3-2		ZDHHC24_ENST00000526986.1_Intron	NM_207340.1	NP_997223.1	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24							integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|large_intestine(3)|ovary(1)|prostate(1)|skin(1)	7						ACACTCTGCCTGCAATAAAAG	0.637000													15	33					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27420565	27420565	+	Missense_Mutation	SNP	G	G	C			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr6:27420565G>C	ENST00000211936.6	-	6	1057	c.773C>G	c.(772-774)gCc>gGc	p.A258G	ZNF184_ENST00000377419.1_Missense_Mutation_p.A258G	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CCGGCTGAAGGCTTTTTCACA	0.378000													27	215					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7528426	7528426	+	Missense_Mutation	SNP	T	T	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr12:7528426T>G	ENST00000313599.3	-	10	2613	c.2556A>C	c.(2554-2556)aaA>aaC	p.K852N	CD163L1_ENST00000416109.2_Missense_Mutation_p.K862N|CD163L1_ENST00000396630.1_Missense_Mutation_p.K852N|CD163L1_ENST00000544331.1_5'UTR			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	852	SRCR 8.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GACCATTCCCTTTTCCAAAGT	0.448000													55	91					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20761037	20761037	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr22:20761037A>G	ENST00000400451.2	+	5	2228	c.1714A>G	c.(1714-1716)Act>Gct	p.T572A	ZNF74_ENST00000405993.1_Missense_Mutation_p.T540A|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.T572A	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	572					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CTCGCACCTCACTGAGCACCA	0.542000													50	66					0	0	1	0	0
ARV1	64801	broad.mit.edu	37	1	231131566	231131567	+	Frame_Shift_Ins	INS	-	-	A			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr1:231131566_231131567insA	ENST00000310256.2	+	4	566_567	c.509_510insA	c.(508-510)gaafs	p.E170fs	ARV1_ENST00000366658.2_Frame_Shift_Ins_p.E130fs|ARV1_ENST00000497753.1_3'UTR	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	170					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		CCCATGACGGCAAAAAAAAAGC	0.381													7	183	---	---	---	---					
CPHL1P	0	broad.mit.edu	37	3	148999032	148999033	+	RNA	INS	-	-	GAA	rs67798399	by1000genomes	TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr3:148999032_148999033insGAA	ENST00000482639.2	-	0	195																											GGGAAGACACTGAACAGtaaga	0.500													2	4	---	---	---	---					
RRAGD	58528	broad.mit.edu	37	6	90097209	90097210	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr6:90097209_90097210delAA	ENST00000369415.4	-	2	524_525	c.248_249delTT	c.(247-249)tfs	p.F83fs	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.2_Intron	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	83					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		ACATTTTGTGAAAGACAACTTT	0.465													208	395	---	---	---	---					
RABGEF1	27342	broad.mit.edu	37	7	66236880	66236882	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr7:66236880_66236882delGAA	ENST00000439720.2	+	2	200_202	c.33_35delGAA	c.(31-36)agg>ag	p.RK11del	KCTD7_ENST00000380828.2_5'UTR|KCTD7_ENST00000510829.2_5'UTR|RABGEF1_ENST00000450873.2_5'UTR|RABGEF1_ENST00000284957.5_5'UTR|RABGEF1_ENST00000484547.2_3'UTR|KCTD7_ENST00000451741.2_5'UTR|RABGEF1_ENST00000437078.2_In_Frame_Del_p.RK12del			Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	136					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|stomach(1)	27						TGGTTAGCAGGAAGAAGATGAGC	0.404													7	133	---	---	---	---					
CTD-3046C4.1	0	broad.mit.edu	37	8	64322187	64322188	+	RNA	INS	-	-	A	rs34341678		TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr8:64322187_64322188insA	ENST00000521221.1	-	0	694																											TGCTCCTGGTTAAAAAAAAAAA	0.480													2	4	---	---	---	---					
ZNF214	0	broad.mit.edu	37	11	7024038	7024039	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr11:7024038_7024039delAT	ENST00000278314.4	-	2	343_344	c.28_29delAT	c.(28-30)tfs	p.I11fs	ZNF214_ENST00000531083.1_5'UTR|ZNF214_ENST00000536068.1_Frame_Shift_Del_p.I11fs	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	11	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TGTAAAAATAATAGTCACATCT	0.381													60	119	---	---	---	---					
CHST11	50515	broad.mit.edu	37	12	104851291	104851294	+	Frame_Shift_Del	DEL	AAGT	AAGT	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr12:104851291_104851294delAAGT	ENST00000303694.5	+	1	541_544	c.102_105delAAGT	c.(100-105)cafs	p.QS34fs	CHST11_ENST00000549260.1_Splice_Site_p.Q34_splice|CHST11_ENST00000546689.1_Splice_Site_p.Q34_splice|CHST11_ENST00000547956.1_Frame_Shift_Del_p.QS34fs	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	34					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						TCTATTTCCAAAGTATGTTGCACC	0.520													8	294	---	---	---	---					
RP11-260M19.2	0	broad.mit.edu	37	14	104706030	104706030	+	RNA	DEL	G	G	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr14:104706030delG	ENST00000555282.1	+	0	203																											CCAAGGCCTTGGAGGTGGTGG	0.667													2	4	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42790954	42790955	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:42790954_42790955delTG	ENST00000572681.2	+	3	2894_2895	c.2826_2827delTG	c.(2824-2829)gctgfs	p.AV942fs	CIC_ENST00000575839.2_3'UTR|CIC_ENST00000160740.3_Frame_Shift_Del_p.AV33fs|CIC_ENST00000575354.2_Frame_Shift_Del_p.AV33fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	33	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCTCTGTGGCTGTGTTCCCTTG	0.644			"""Mis, F, S"""		oligodendroglioma								18	52	---	---	---	---					
NOVA2	4858	broad.mit.edu	37	19	46476609	46476610	+	Translation_Start_Site	INS	-	-	G			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr19:46476609_46476610insG	ENST00000263257.5	-	0	194_195					NM_002516.2	NP_002507.1	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2							nucleus	RNA binding			endometrium(3)|large_intestine(5)|lung(13)	21		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		TCGGGCTCCATGGGGGGGGCCT	0.762													3	3	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21196122	21196123	+	RNA	DEL	AA	AA	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chr20:21196122_21196123delAA	ENST00000591761.1	-	0	119				RP4-777D9.2_ENST00000443753.1_RNA|PLK1S1_ENST00000457464.1_RNA|RP4-777D9.2_ENST00000433213.2_RNA																							TACATTAACCAAAAAAAAAAAA	0.248													3	2	---	---	---	---					
XIST	0	broad.mit.edu	37	X	73061239	73061241	+	RNA	DEL	TCT	TCT	-			TCGA-TQ-A7RI-01A-11D-A33T-08	TCGA-TQ-A7RI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92fdb7b7-7e35-48a7-a00c-a63753726d81	c8b7a13a-9f33-4121-91a7-ad79b54b9070	g.chrX:73061239_73061241delTCT	ENST00000429829.1	-	0	11347_11349					NR_001564.2																						AGCCAGAGACTCTTCTTTACAGC	0.394													15	65	---	---	---	---