Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SHC3	53358	broad.mit.edu	37	9	91727511	91727511	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr9:91727511T>C	ENST00000375835.4	-	2	811	c.505A>G	c.(505-507)Atg>Gtg	p.M169V	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	169	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						AGAGACCTCATTGAGCGCAGA	0.413000													32	61					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3188882	3188882	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr18:3188882C>T	ENST00000400569.3	-	4	968	c.635G>A	c.(634-636)aGg>aAg	p.R212K	MYOM1_ENST00000356443.4_Missense_Mutation_p.R212K|MYOM1_ENST00000261606.7_Missense_Mutation_p.R212K			P52179	MYOM1_HUMAN	myomesin 1	212	6 X 6 AA tandem repeats.					striated muscle myosin thick filament	structural constituent of muscle	p.R212K(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CGTGGACTGCCTGGATGCCGT	0.517000													3	61					0	0	1	0	0
CIB1	10519	broad.mit.edu	37	15	90774627	90774627	+	Missense_Mutation	SNP	G	G	A	rs147405990	byFrequency	TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr15:90774627G>A	ENST00000328649.6	-	4	469	c.308C>T	c.(307-309)aCg>aTg	p.T103M		NM_006384.3	NP_006375.2	Q99828	CIB1_HUMAN	calcium and integrin binding 1 (calmyrin)	103	EF-hand 1.				apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding			lung(1)|prostate(1)	2	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			GATGTCTGGCGTGGCTGTGTC	0.572000													18	7					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119626790	119626790	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr4:119626790G>A	ENST00000388822.4	+	10	1047	c.880G>A	c.(880-882)Gga>Aga	p.G294R	METTL14_ENST00000506780.1_Missense_Mutation_p.G256R			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	294						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						GGGGATCAAAGGAACTGTGAA	0.388000													10	56					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21557518	21557518	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr13:21557518G>A	ENST00000382592.4	-	5	2732	c.2327C>T	c.(2326-2328)aCt>aTt	p.T776I	LATS2_ENST00000542899.1_Missense_Mutation_p.T776I	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	776	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		AATGGCCAAAGTCAGCTCTGC	0.502000													3	47					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3615007	3615007	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr20:3615007C>T	ENST00000262919.5	+	26	3981	c.3913C>T	c.(3913-3915)Caa>Taa	p.Q1305*		NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	1305					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						GAAGATCAAACAAAGTTGTTG	0.443000													17	46					0	0	1	0	0
IGHG4	0	broad.mit.edu	37	14	106091267	106091267	+	RNA	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr14:106091267C>T	ENST00000390543.2	-	0	626																											CGATGGAGGACGGGAGGCCTT	0.612000													128	362					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92929289	92929289	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr5:92929289C>T	ENST00000327111.3	+	3	2700	c.1013C>T	c.(1012-1014)gCg>gTg	p.A338V	NR2F1_ENST00000506162.1_3'UTR	NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	338					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CTGTCGGATGCGGCCCACATC	0.592000													4	201					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136569943	136569943	+	Missense_Mutation	SNP	T	T	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr2:136569943T>A	ENST00000264162.2	-	7	2301	c.2291A>T	c.(2290-2292)aAt>aTt	p.N764I		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	764	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATCAAAGAGATTTTCACTTTC	0.433000													19	160					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78752755	78752755	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr5:78752755G>A	ENST00000334082.6	-	2	1534	c.92C>T	c.(91-93)gCa>gTa	p.A31V	HOMER1_ENST00000282260.6_Missense_Mutation_p.A31V|HOMER1_ENST00000535690.1_Intron|HOMER1_ENST00000508576.1_Missense_Mutation_p.A31V	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	31	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		CACAGTAACTGCATGCTTGCT	0.423000													4	206					0	0	1	0	0
NDUFAF4	29078	broad.mit.edu	37	6	97344686	97344686	+	Missense_Mutation	SNP	A	A	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr6:97344686A>T	ENST00000316149.7	-	2	253	c.174T>A	c.(172-174)gaT>gaA	p.D58E	NDUFAF4_ENST00000489477.1_5'UTR	NM_014165.3	NP_054884.1	Q9P032	NDUF4_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 4	58					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			large_intestine(5)|lung(3)|ovary(1)|skin(1)	10						GCAGCTTTTCATCTTTACGAG	0.333000													10	143					0	0	1	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043725	26043725	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr6:26043725C>T	ENST00000357905.2	-	1	160	c.161G>A	c.(160-162)gGc>gAc	p.G54D		NM_021062.2	NP_066406.1	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	54					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GGATGAGATGCCGGTGTCGGG	0.547000													5	234					0	0	1	0	0
SLC35A3	23443	broad.mit.edu	37	1	100477024	100477024	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr1:100477024G>A	ENST00000465289.1	+	5	961	c.569G>A	c.(568-570)gGg>gAg	p.G190E	SLC35A3_ENST00000370153.1_Missense_Mutation_p.G232E|SLC35A3_ENST00000370156.3_3'UTR|SLC35A3_ENST00000370155.3_Missense_Mutation_p.G190E|SLC35A3_ENST00000427993.2_Missense_Mutation_p.G190E	NM_001271684.1	NP_001258613.1	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	190					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity	p.G190E(1)		biliary_tract(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	11		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		GGCTTTGCTGGGGTTTACTTT	0.338000													12	25					0	0	1	0	0
RTP3	83597	broad.mit.edu	37	3	46542360	46542360	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr3:46542360G>A	ENST00000296142.3	+	2	1242	c.670G>A	c.(670-672)Gtg>Atg	p.V224M		NM_031440.1	NP_113628.1	Q9BQQ7	RTP3_HUMAN	receptor (chemosensory) transporter protein 3	224					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			endometrium(1)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CATTGTTATCGTGGTGATTGT	0.378000													16	54					0	0	1	0	0
XRCC5	7520	broad.mit.edu	37	2	216977761	216977761	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr2:216977761A>G	ENST00000392133.3	+	4	505	c.44A>G	c.(43-45)gAc>gGc	p.D15G	XRCC5_ENST00000392132.2_Missense_Mutation_p.D15G			P13010	XRCC5_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	15				MDV -> YSY (in Ref. 10; AA sequence).	double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			endometrium(1)|kidney(3)|large_intestine(8)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		CTGTGTATGGACGTGGGCTTT	0.408000								Non-homologous end-joining					54	70					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								23	32					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886828	227886828	+	Silent	SNP	C	C	T	rs75398993	by1000genomes	TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr2:227886828C>T	ENST00000396625.3	-	44	4359	c.4152G>A	c.(4150-4152)gcG>gcA	p.A1384A	COL4A4_ENST00000329662.7_Silent_p.A1381A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1384	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCATGCCTGGCGCCCCAGGAA	0.567000													79	168					0	0	1	0	0
PALM2-AKAP2	0	broad.mit.edu	37	9	112918685	112918685	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr9:112918685G>A	ENST00000374530.3	+	9	3262	c.3082G>A	c.(3082-3084)Gga>Aga	p.G1028R	AKAP2_ENST00000482335.1_Intron|AKAP2_ENST00000374525.1_Missense_Mutation_p.G886R|AKAP2_ENST00000510514.5_Missense_Mutation_p.G1028R|PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.G1028R|AKAP2_ENST00000434623.2_Missense_Mutation_p.G886R|AKAP2_ENST00000555236.1_Missense_Mutation_p.G1028R|AKAP2_ENST00000259318.7_Missense_Mutation_p.G797R	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		797							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						AGAGGCTGCCGGAACCCAGCG	0.507000													13	59					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22161160	22161160	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr16:22161160G>A	ENST00000389397.4	+	30	3205	c.343G>A	c.(343-345)Gtg>Atg	p.V115M	VWA3A_ENST00000563755.1_Missense_Mutation_p.V115M|VWA3A_ENST00000389398.5_Missense_Mutation_p.V1013M			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1013						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GGACACGCTGGTGGAGACCAC	0.557000													5	14					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1057736	1057736	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr5:1057736G>A	ENST00000264930.5	-	22	2919	c.2876C>T	c.(2875-2877)gCg>gTg	p.A959V		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	959					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GGTGTGGGACGCGGTGTTCCT	0.662000													17	175					0	0	1	0	0
CSAG4	0	broad.mit.edu	37	X	151896231	151896231	+	RNA	SNP	A	A	G			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chrX:151896231A>G	ENST00000361201.4	-	0	499					NR_073432.1															endometrium(2)|kidney(2)|lung(1)	5						GAGTGGCTGGATAGTGTTGGC	0.517000													3	12					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256928	69256928	+	Silent	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr14:69256928G>A	ENST00000439696.2	-	2	640	c.339C>T	c.(337-339)agC>agT	p.S113S	ZFP36L1_ENST00000336440.3_Silent_p.S113S|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	113					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCTTGTAGCGGCTGGAGTTGA	0.672000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	170					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30693212	30693212	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr7:30693212C>T	ENST00000471646.1	-	12	1517	c.1100G>A	c.(1099-1101)cGc>cAc	p.R367H	CRHR2_ENST00000506074.2_3'UTR|CRHR2_ENST00000348438.4_Missense_Mutation_p.R394H|CRHR2_ENST00000341843.4_Missense_Mutation_p.R353H	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	367					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding	p.R367H(1)		breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CACGGCTGAGCGCACCTGTGG	0.642000													11	54					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113238566	113238566	+	Silent	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr9:113238566G>A	ENST00000401783.2	-	14	2853	c.2517C>T	c.(2515-2517)gaC>gaT	p.D839D	SVEP1_ENST00000374461.1_Silent_p.D816D|SVEP1_ENST00000374469.1_Silent_p.D816D|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Silent_p.D839D	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	839					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGCAGTCAATGTCCTCTGCAT	0.373000													20	101					0	0	1	0	0
FAM172A	83989	broad.mit.edu	37	5	93386527	93386527	+	Nonsense_Mutation	SNP	A	A	C			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr5:93386527A>C	ENST00000395965.3	-	4	360	c.218T>G	c.(217-219)tTa>tGa	p.L73*	FAM172A_ENST00000509739.1_Intron|FAM172A_ENST00000504768.2_5'UTR|FAM172A_ENST00000509163.1_Nonsense_Mutation_p.L27*|FAM172A_ENST00000505869.1_Nonsense_Mutation_p.L27*	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	73						endoplasmic reticulum|extracellular region				endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						TATGTGTCTTAACTGTCCCTC	0.328000													62	72					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791869	42791869	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr19:42791869T>C	ENST00000572681.2	+	6	3550	c.3482T>C	c.(3481-3483)cTg>cCg	p.L1161P	CIC_ENST00000160740.3_Missense_Mutation_p.L252P|CIC_ENST00000575354.2_Missense_Mutation_p.L252P			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	252	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TACCACGACCTGGCCTTCCAG	0.617000			"""Mis, F, S"""		oligodendroglioma								18	16					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107084062	107084062	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chrX:107084062G>A	ENST00000262843.6	+	2	715	c.167G>A	c.(166-168)cGc>cAc	p.R56H	MID2_ENST00000443968.2_Missense_Mutation_p.R56H	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	56						centrosome|microtubule	ligase activity|zinc ion binding	p.R36H(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						TGTGCCCATCGCATTTTGGTA	0.517000													77	62					0	0	1	0	0
PCDHGB4	0	broad.mit.edu	37	5	140769051	140769051	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr5:140769051G>A	ENST00000519479.1	+	1	1600	c.1600G>A	c.(1600-1602)Gac>Aac	p.D534N	PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGCCCGCGACCAGGGCTC	0.682000													12	31					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59750659	59750659	+	Nonsense_Mutation	SNP	A	A	C			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr8:59750659A>C	ENST00000361421.1	-	5	1125	c.905T>G	c.(904-906)tTa>tGa	p.L302*		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	302						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CTCTTCTCCTAAACCGTCCCA	0.483000													43	45					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371406	240371406	+	Silent	SNP	T	T	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr1:240371406T>A	ENST00000319653.9	+	5	3524	c.3294T>A	c.(3292-3294)ccT>ccA	p.P1098P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1098	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCATACCCCCTCCGCCCCCTC	0.731000													5	19					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819305	43819305	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr15:43819305G>A	ENST00000382031.1	+	5	6379	c.6348G>A	c.(6346-6348)tgG>tgA	p.W2116*	MAP1A_ENST00000300231.5_Nonsense_Mutation_p.W1878*|MAP1A_ENST00000399453.1_Nonsense_Mutation_p.W1878*			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1878						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCTTCTCTTGGGGCACAGCCG	0.662000													4	26					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100421309	100421309	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr7:100421309G>T	ENST00000358173.3	-	3	836	c.368C>A	c.(367-369)gCc>gAc	p.A123D	EPHB4_ENST00000360620.3_Missense_Mutation_p.A123D|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	123					cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					GAGGGCCGTGGCCGTGTCCGC	0.647000													28	37					2.61193e-14	2.67267e-14	1	1	0
CPAMD8	27151	broad.mit.edu	37	19	17015067	17015067	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr19:17015067C>T	ENST00000443236.1	-	32	4392	c.4361G>A	c.(4360-4362)cGa>cAa	p.R1454Q		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1407						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AAGTGCATTTCGCTGCTGGGA	0.652000													5	22					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144835835	144835835	+	Missense_Mutation	SNP	G	G	A	rs115466543	by1000genomes	TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr6:144835835G>A	ENST00000367545.3	+	36	5123	c.5123G>A	c.(5122-5124)cGc>cAc	p.R1708H		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1708	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAAAATGTCCGCGATCAAGCC	0.413000													29	156					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400918	195400919	+	RNA	INS	-	-	T	rs55992531	by1000genomes	TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr3:195400918_195400919insT	ENST00000445430.1	+	0	1454																											AGTCttttttctttttttttga	0.525													6	10	---	---	---	---					
HIST1H1E	3008	broad.mit.edu	37	6	26156983	26156984	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr6:26156983_26156984delAG	ENST00000304218.3	+	1	425_426	c.365_366delAG	c.(364-366)afs	p.K122fs		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	122					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						AAGGCTAAAAAGGCAGGCGCGG	0.639													7	45	---	---	---	---					
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	GCT	-	rs34222232		TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr9:139277995_139277997delGCT	ENST00000298532.2	-	15	1992_1994	c.1624_1626delAGC	c.(1624-1626)del	p.S542del		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.S542delS(2)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.690													6	7	---	---	---	---					
SNX29P2	0	broad.mit.edu	37	16	29337651	29337652	+	RNA	INS	-	-	CAGAG	rs140530121	by1000genomes	TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chr16:29337651_29337652insCAGAG	ENST00000398878.3	+	0	724																											CCCCGTTCACACCTGTTTCCTC	0.599													6	11	---	---	---	---					
WWC3	55841	broad.mit.edu	37	X	10085617	10085617	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TM-A7C5-01A-11D-A32B-08	TCGA-TM-A7C5-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64adb394-e415-4156-929b-da1b13c26af4	474aa4ed-af9d-4973-965e-d1217db30a43	g.chrX:10085617delG	ENST00000380861.4	+	11	1909	c.1518delG	c.(1516-1518)atfs	p.M506fs	WWC3_ENST00000454666.1_Frame_Shift_Del_p.M506fs	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	506										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CCTCGGCTATGGGGGACGAAG	0.721													2	4	---	---	---	---