Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIR508	0	broad.mit.edu	37	X	146318444	146318444	+	RNA	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chrX:146318444G>A	ENST00000384857.1	-	0	101					NR_030235.1																						CCAAATATGCGTTACGTGATG	0.507000													20	2					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62751626	62751626	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr3:62751626G>A	ENST00000383710.4	-	2	824	c.475C>T	c.(475-477)Cgg>Tgg	p.R159W	CADPS_ENST00000357948.3_Missense_Mutation_p.R159W|CADPS_ENST00000283269.9_Missense_Mutation_p.R159W|CADPS_ENST00000490353.2_Missense_Mutation_p.R159W	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	159					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GCCTGAAACCGGTCCTTGACT	0.453000													36	70					0	0	1	0	0
KLHL23	151230	broad.mit.edu	37	2	170592131	170592131	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr2:170592131C>A	ENST00000392647.2	+	2	851	c.607C>A	c.(607-609)Cca>Aca	p.P203T	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Missense_Mutation_p.P203T	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	203	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						TATCATAGAGCCAGTTATTAA	0.353000													3	69					0.115264	0.115264	1	1	0
CIC	23152	broad.mit.edu	37	19	42791715	42791715	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr19:42791715C>T	ENST00000572681.2	+	6	3396	c.3328C>T	c.(3328-3330)Cgg>Tgg	p.R1110W	CIC_ENST00000160740.3_Missense_Mutation_p.R201W|CIC_ENST00000575354.2_Missense_Mutation_p.R201W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	201	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R201W(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGACCACATCCGGCGGCCCAT	0.622000			"""Mis, F, S"""		oligodendroglioma								32	5					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1266182	1266182	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr11:1266182C>T	ENST00000447027.1	+	31	8139	c.8081C>T	c.(8080-8082)aCc>aTc	p.T2694I	MUC5B_ENST00000529681.1_Missense_Mutation_p.T2691I|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2691	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ccatcactgaccaccacggcc	0.622000													6	10					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P|FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													4	167					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65491077	65491077	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr15:65491077C>T	ENST00000261883.4	-	9	1713	c.1547G>A	c.(1546-1548)cGt>cAt	p.R516H		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	516					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CATGCTTACACGGCTGTTCCC	0.582000													21	30					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440030	40440030	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr4:40440030G>A	ENST00000319592.4	-	4	1590	c.881C>T	c.(880-882)gCc>gTc	p.A294V	RBM47_ENST00000295971.7_Missense_Mutation_p.A294V|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000514014.1_Missense_Mutation_p.A256V|RBM47_ENST00000381795.6_Missense_Mutation_p.A294V|RBM47_ENST00000381793.2_Missense_Mutation_p.A294V			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	294	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						GGCATGCACGGCATCCTCGCG	0.622000													3	50					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236706492	236706492	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr2:236706492G>A	ENST00000409538.1	+	7	2054	c.1558G>A	c.(1558-1560)Gtc>Atc	p.V520I	AGAP1_ENST00000304032.7_Missense_Mutation_p.V255I|AGAP1_ENST00000336665.5_Missense_Mutation_p.V255I|AGAP1_ENST00000409457.1_Missense_Mutation_p.V255I|AGAP1_ENST00000428334.2_Missense_Mutation_p.V94I			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	255	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCATTCCTCCGTCTGTTCCGC	0.512000													14	191					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120302572	120302572	+	Nonsense_Mutation	SNP	A	A	T			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr1:120302572A>T	ENST00000369406.3	-	3	649	c.600T>A	c.(598-600)taT>taA	p.Y200*	HMGCS2_ENST00000544913.2_Intron|HMGCS2_ENST00000476640.1_5'UTR	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	200					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TACCACTGGGATAGACGGCAA	0.517000													3	23					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	96					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48380873	48380873	+	Silent	SNP	C	C	T			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr12:48380873C>T	ENST00000380518.3	-	21	1517	c.1353G>A	c.(1351-1353)ccG>ccA	p.P451P	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Silent_p.P382P	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	451	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCTGACCTTTCGGGCCCAGAG	0.622000													43	46					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12296198	12296198	+	Silent	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr6:12296198G>A	ENST00000379375.5	+	5	804	c.537G>A	c.(535-537)tcG>tcA	p.S179S		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	179					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity	p.S179S(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				TTATTAGGTCGGAGACCATGA	0.393000													11	146					0	0	1	0	0
ANO6	196527	broad.mit.edu	37	12	45741926	45741926	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr12:45741926G>A	ENST00000320560.8	+	5	663	c.461G>A	c.(460-462)cGg>cAg	p.R154Q	ANO6_ENST00000441606.2_Missense_Mutation_p.R136Q|ANO6_ENST00000435642.1_Missense_Mutation_p.R154Q|ANO6_ENST00000425752.2_Missense_Mutation_p.R154Q|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000423947.3_Missense_Mutation_p.R175Q	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	154					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						CTGAAAAACCGGTCCTCAGCC	0.438000													41	47					0	0	1	0	0
RNF214	257160	broad.mit.edu	37	11	117153161	117153161	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr11:117153161G>A	ENST00000530849.1	+	11	1299	c.1289G>A	c.(1288-1290)cGt>cAt	p.R430H	RNF214_ENST00000300650.4_Missense_Mutation_p.R585H|RNF214_ENST00000531452.1_Missense_Mutation_p.R585H|RNF214_ENST00000531287.1_Missense_Mutation_p.R430H|RNF214_ENST00000524917.1_3'UTR			Q8ND24	RN214_HUMAN	ring finger protein 214	585							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		AAGACAGCACGTACCACCATG	0.517000													28	26					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	23848694	23848694	+	Splice_Site	SNP	A	A	G			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr16:23848694A>G	ENST00000303531.7	+	2	325		c.e2-1		PRKCB_ENST00000498058.1_Intron|PRKCB_ENST00000321728.7_Splice_Site	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta						apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	CTGCTTTTGCAGGGGCTTCGG	0.567000													4	169					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796320	167796320	+	Silent	SNP	G	G	A			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr6:167796320G>A	ENST00000366827.2	-	2	253	c.42C>T	c.(40-42)gaC>gaT	p.D14D	TCP10_ENST00000397829.4_Silent_p.D14D|TCP10_ENST00000476779.2_Silent_p.D14D			Q12799	TCP10_HUMAN	t-complex 10	41						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		CGGCATTGCTGTCCTCCCTGG	0.652000													3	24					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								47	55					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													4	39					0	0	1	0	0
AC007383.4	0	broad.mit.edu	37	2	206981155	206981155	+	RNA	DEL	C	C	-	rs71410864		TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr2:206981155delC	ENST00000453039.1	+	0	885					NR_033248.1																						AGGCAGGGCGCGGCAGGTGCC	0.627													5	9	---	---	---	---					
LINC00971	0	broad.mit.edu	37	3	84741480	84741480	+	RNA	DEL	A	A	-	rs140144338		TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr3:84741480delA	ENST00000484892.1	-	0	2354					NR_033860.1																						CCTGTCCCAGAAAAAAAAAAA	0.388													3	4	---	---	---	---					
LMOD2	442721	broad.mit.edu	37	7	123301995	123301997	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr7:123301995_123301997delGAG	ENST00000458573.2	+	2	512_514	c.355_357delGAG	c.(355-357)del	p.E124del	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	124	Glu-rich.					cytoskeleton	actin binding|tropomyosin binding										AGTGTATACAgaggaggaggagg	0.409													2	4	---	---	---	---					
KAT6A	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chr8:41798420_41798422delCTC	ENST00000396930.3	-	16	3520_3522	c.2977_2979delGAG	c.(2977-2979)del	p.E993del	KAT6A_ENST00000265713.2_In_Frame_Del_p.E993del|KAT6A_ENST00000406337.1_In_Frame_Del_p.E993del	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GGCTTTCCGGCTCCTCCTCCTCC	0.567													7	160	---	---	---	---					
BCORL1	63035	broad.mit.edu	37	X	129155055	129155055	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S9-A7J2-01A-11D-A34A-08	TCGA-S9-A7J2-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41ec5804-ccd5-4a03-b250-4936b783ad4a	9807aded-c9bc-4500-b7ba-32967f7019df	g.chrX:129155055delG	ENST00000540052.1	+	4	3581	c.3537delG	c.(3535-3537)aafs	p.K1179fs	BCORL1_ENST00000218147.7_Frame_Shift_Del_p.K1179fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.K1179fs|BCORL1_ENST00000359304.2_Frame_Shift_Del_p.K1179fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1179					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						TCAGGGGAAAGCACAAGCACC	0.622													15	3	---	---	---	---