Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FANK1	92565	broad.mit.edu	37	10	127693465	127693465	+	Silent	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr10:127693465G>A	ENST00000368695.1	+	7	656	c.534G>A	c.(532-534)gcG>gcA	p.A178A	FANK1_ENST00000477963.1_3'UTR|FANK1_ENST00000368693.1_Silent_p.A184A	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	184						cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				TAATGCTGGCGTGCTATGCGG	0.507000													6	81					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37026330	37026330	+	Splice_Site	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr5:37026330G>A	ENST00000282516.8	+	31	6208		c.e31-1		NIPBL_ENST00000448238.2_Splice_Site	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTTCCTTCTAGAAATTAGTAA	0.313000													13	24					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41296926	41296926	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr1:41296926G>A	ENST00000347132.5	+	10	1545	c.1463G>A	c.(1462-1464)cGc>cAc	p.R488H	KCNQ4_ENST00000509682.2_Missense_Mutation_p.R434H|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	488					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TTCAATGACCGCACCCGCTTC	0.652000													5	2					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148709068	148709068	+	Silent	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr7:148709068G>A	ENST00000286091.4	-	6	1081	c.849C>T	c.(847-849)tcC>tcT	p.S283S		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	283	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			AGGGAGGCCCGGACTGCTCGA	0.582000													4	60					0	0	1	0	0
ATP4B	496	broad.mit.edu	37	13	114312443	114312443	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr13:114312443T>A	ENST00000335288.4	-	1	58	c.17A>T	c.(16-18)gAg>gTg	p.E6V		NM_000705.3	NP_000696.1	P51164	ATP4B_HUMAN	ATPase, H+/K+ exchanging, beta polypeptide	6					ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	CGTCTTCTTCTCCTGCAGAGC	0.642000													5	29					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39994226	39994226	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:39994226G>A	ENST00000336649.4	+	4	307	c.307G>A	c.(307-309)Gac>Aac	p.D103N	CACNA1I_ENST00000404898.1_Missense_Mutation_p.D103N|CACNA1I_ENST00000402142.3_Missense_Mutation_p.D103N|CACNA1I_ENST00000401624.1_Missense_Mutation_p.D103N|CACNA1I_ENST00000400164.3_Missense_Mutation_p.D103N|CACNA1I_ENST00000407673.1_Missense_Mutation_p.D103N			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	103					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCAGCCGTGCGACGACATGGA	0.632000													3	16					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109826586	109826586	+	Silent	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr12:109826586G>A	ENST00000310903.5	+	2	169	c.63G>A	c.(61-63)gcG>gcA	p.A21A	MYO1H_ENST00000431443.2_Silent_p.A21A			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						TATTGGACGCGTACACCAGCG	0.532000													4	208					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791853	42791853	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr19:42791853C>T	ENST00000572681.2	+	6	3534	c.3466C>T	c.(3466-3468)Cag>Tag	p.Q1156*	CIC_ENST00000575354.2_Nonsense_Mutation_p.Q247*|CIC_ENST00000160740.3_Nonsense_Mutation_p.Q247*			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	247	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAAGGAGAAGCAGAAGTACCA	0.632000			"""Mis, F, S"""		oligodendroglioma								4	23					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65678327	65678327	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr15:65678327C>A	ENST00000352385.2	-	18	3231	c.3022G>T	c.(3022-3024)Ggc>Tgc	p.G1008C		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1008						integral to membrane|plasma membrane		p.G1008C(1)		NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CTGGGGGGGCCAAGCCGAGCT	0.662000											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					1.06961e-07	1.24788e-07	1	1	0
MFSD10	10227	broad.mit.edu	37	4	2933825	2933825	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr4:2933825G>A	ENST00000329687.4	-	6	1283	c.749C>T	c.(748-750)gCc>gTc	p.A250V	MFSD10_ENST00000514800.1_Missense_Mutation_p.A250V|MFSD10_ENST00000507555.1_Missense_Mutation_p.A250V|MFSD10_ENST00000508221.1_Missense_Mutation_p.A250V|MFSD10_ENST00000355443.4_Missense_Mutation_p.A250V	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	250					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCGCAGCAGGGCCAGGGGGCT	0.672000													6	12					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100117175	100117175	+	Splice_Site	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr9:100117175C>A	ENST00000375202.2	+	38	4633	c.3279_splice	c.e38-1	p.A1094_splice	CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000357054.1_Splice_Site_p.A1065_splice|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000529487.1_Splice_Site_p.A1094_splice					coiled-coil domain containing 180																		TCTGTACAGGCCAATGATGTC	0.463000													10	66					6.40141e-05	7.07524e-05	1	1	0
GIGYF2	26058	broad.mit.edu	37	2	233712219	233712219	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:233712219C>T	ENST00000373566.3	+	28	3885	c.3688C>T	c.(3688-3690)Cag>Tag	p.Q1230*	GIGYF2_ENST00000409480.1_Nonsense_Mutation_p.Q1230*|GIGYF2_ENST00000409547.1_Nonsense_Mutation_p.Q1208*|GIGYF2_ENST00000409451.3_Nonsense_Mutation_p.Q1229*|GIGYF2_ENST00000409196.3_Nonsense_Mutation_p.Q1202*|GIGYF2_ENST00000373563.4_Nonsense_Mutation_p.Q1208*			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1208	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		tcagcagcagcagctgccaca	0.572000													9	84					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	5					6.4e-05	7.07524e-05	1	1	0
SLC35A4	113829	broad.mit.edu	37	5	139947214	139947214	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr5:139947214G>T	ENST00000514199.1	+	2	2146	c.460G>T	c.(460-462)Gcc>Tcc	p.A154S	SLC35A4_ENST00000323146.3_Missense_Mutation_p.A154S|APBB3_ENST00000507279.1_Intron			Q96G79	S35A4_HUMAN	solute carrier family 35, member A4	154	Leu-rich.					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTGCGGGAGCCTGCTATGC	0.637000													5	46					0.000602214	0.000616903	1	1	0
QARS	5859	broad.mit.edu	37	3	49141306	49141306	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr3:49141306A>G	ENST00000306125.6	-	3	702	c.365T>C	c.(364-366)aTt>aCt	p.I122T	QARS_ENST00000414533.1_Missense_Mutation_p.I111T|QARS_ENST00000420147.2_Missense_Mutation_p.I140T			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	122					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGCCTCCTCAATCTGCTCTGG	0.592000													7	29					0	0	1	0	0
CCND1	595	broad.mit.edu	37	11	69465934	69465934	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr11:69465934A>G	ENST00000227507.2	+	5	999	c.772A>G	c.(772-774)Agc>Ggc	p.S258G		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	258					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	GCTGGAGTCAAGCCTGCGCCA	0.667000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			14	16					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57968233	57968233	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr17:57968233G>T	ENST00000325752.3	-	2	408	c.131C>A	c.(130-132)gCa>gAa	p.A44E	TUBD1_ENST00000539018.1_Intron|TUBD1_ENST00000592426.1_Missense_Mutation_p.A44E|TUBD1_ENST00000591611.1_5'UTR|TUBD1_ENST00000376094.4_Missense_Mutation_p.A44E|TUBD1_ENST00000394239.3_Missense_Mutation_p.A44E|TUBD1_ENST00000346141.6_Missense_Mutation_p.A44E|TUBD1_ENST00000340993.6_Missense_Mutation_p.A44E	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	44					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TTTGCAAGATGCTTGATATGC	0.458000													4	125					0.00116845	0.00116845	1	1	0
ING5	84289	broad.mit.edu	37	2	242650843	242650843	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:242650843G>T	ENST00000313552.6	+	4	354	c.328G>T	c.(328-330)Gat>Tat	p.D110Y	ING5_ENST00000406941.1_Missense_Mutation_p.D110Y|ING5_ENST00000482774.1_3'UTR	NM_032329.4	NP_115705.2	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	110					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			large_intestine(1)|lung(1)|skin(1)	3		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CTTTGAAGCAGATCTGAAGGA	0.393000													79	121					6.44939e-38	8.20832e-38	1	1	0
CD97	976	broad.mit.edu	37	19	14499539	14499539	+	Silent	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr19:14499539C>T	ENST00000242786.5	+	3	179	c.99C>T	c.(97-99)aaC>aaT	p.N33N	CD97_ENST00000587728.1_3'UTR|CD97_ENST00000358600.3_Silent_p.N33N|CD97_ENST00000357355.3_Silent_p.N33N	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	33	EGF-like 1.				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCCCTCAGAACTCCTCGTGTG	0.587000													5	171					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	93					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3701451	3701451	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr12:3701451A>G	ENST00000382622.3	+	9	1424	c.1034A>G	c.(1033-1035)tAc>tGc	p.Y345C	PRMT8_ENST00000452611.2_Missense_Mutation_p.Y336C|PRMT8_ENST00000261252.4_3'UTR	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	345					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TTGGAAGATTACCTCACTGTC	0.532000													39	72					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	5					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								32	54					0	0	1	0	0
IFIH1	64135	broad.mit.edu	37	2	163124706	163124706	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:163124706G>T	ENST00000263642.2	-	14	3093	c.2698C>A	c.(2698-2700)Cca>Aca	p.P900T		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	900					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						ATTAGTGATGGGTTATTCTTG	0.363000													21	39					2.39187e-15	2.95467e-15	1	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35944787	35944787	+	Silent	SNP	A	A	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr1:35944787A>G	ENST00000325722.3	-	4	927	c.693T>C	c.(691-693)agT>agC	p.S231S		NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	231						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGGTTAGGGGACTGGAAATTG	0.408000													33	18					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	93					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752433	62752433	+	RNA	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr7:62752433C>A	ENST00000331425.6	-	0	1002					NR_003952.1																						TATGAATTCTCTTATGTCTAG	0.438000													5	16					0.000602214	0.000616903	1	1	0
DNAH7	56171	broad.mit.edu	37	2	196642630	196642630	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:196642630C>T	ENST00000312428.6	-	59	11058	c.10958G>A	c.(10957-10959)cGc>cAc	p.R3653H	DNAH7_ENST00000409063.1_Missense_Mutation_p.R136H	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3653					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GCGCAGCGTGCGCCGGTCCCA	0.473000													23	31					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	535886	535886	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr19:535886G>A	ENST00000215574.4	+	2	445	c.227G>A	c.(226-228)cGg>cAg	p.R76Q		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	76					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGCCTTTCGGTTCCTGACC	0.647000													35	324					0	0	1	0	0
ADORA2B	136	broad.mit.edu	37	17	15878191	15878191	+	Silent	SNP	C	C	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr17:15878191C>G	ENST00000304222.2	+	2	866	c.534C>G	c.(532-534)ccC>ccG	p.P178P		NM_000676.2	NP_000667.1	P29275	AA2BR_HUMAN	adenosine A2b receptor	178	Agonist binding (By similarity).				activation of MAPK activity|cellular defense response|excretion|JNK cascade	integral to plasma membrane				breast(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)	9				UCEC - Uterine corpus endometrioid carcinoma (92;0.0855)	Defibrotide(DB04932)|Enprofylline(DB00824)|Pegademase bovine(DB00061)|Theophylline(DB00277)	ATGTGGTCCCCATGAGCTACA	0.478000													21	30					0	0	1	0	0
NDRG3	57446	broad.mit.edu	37	20	35293691	35293691	+	Nonsense_Mutation	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr20:35293691C>A	ENST00000373803.2	-	11	762	c.706G>T	c.(706-708)Gag>Tag	p.E236*	NDRG3_ENST00000373773.3_Nonsense_Mutation_p.E141*|NDRG3_ENST00000349004.1_Nonsense_Mutation_p.E236*|NDRG3_ENST00000540765.1_Nonsense_Mutation_p.E132*|NDRG3_ENST00000359675.2_Nonsense_Mutation_p.E224*			Q9UGV2	NDRG3_HUMAN	NDRG family member 3	236					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Myeloproliferative disorder(115;0.00878)				CTTTCGATCTCCAGGTCTCTG	0.368000													5	143					0.000602214	0.000616903	1	1	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													4	66					0	0	1	0	0
CBY1	25776	broad.mit.edu	37	22	39064094	39064094	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr22:39064094A>G	ENST00000216029.3	+	2	169	c.35A>G	c.(34-36)aAg>aGg	p.K12R	RP3-508I15.9_ENST00000431924.2_RNA|RP3-508I15.10_ENST00000423346.1_RNA|RP3-508I15.9_ENST00000422408.1_RNA	NM_015373.3	NP_056188.1	Q9Y3M2	CBY1_HUMAN	chibby homolog 1 (Drosophila)	12					cardiac muscle cell differentiation|fat cell differentiation|negative regulation of transcription, DNA-dependent|protein localization	nuclear speck|trans-Golgi network	beta-catenin binding|identical protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	Melanoma(58;0.04)					AGTCCGAAGAAGACACCTCCT	0.537000													26	38					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152690656	152690656	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr6:152690656T>C	ENST00000367255.5	-	60	10202	c.9601A>G	c.(9601-9603)Aat>Gat	p.N3201D	SYNE1_ENST00000423061.1_Missense_Mutation_p.N3208D|SYNE1_ENST00000265368.4_Missense_Mutation_p.N3201D|SYNE1_ENST00000341594.5_Missense_Mutation_p.N3240D|SYNE1_ENST00000448038.1_Missense_Mutation_p.N3208D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3201					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAGAGGCGATTGCTGCTTTCA	0.512000										HNSCC(10;0.0054)			8	58					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	27					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5410585	5410585	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr18:5410585C>T	ENST00000341928.2	-	14	2441	c.2101G>A	c.(2101-2103)Ggg>Agg	p.G701R	EPB41L3_ENST00000540638.2_Missense_Mutation_p.G532R|EPB41L3_ENST00000342933.3_Missense_Mutation_p.G701R|EPB41L3_ENST00000544123.1_Missense_Mutation_p.G532R|EPB41L3_ENST00000427684.2_5'UTR|EPB41L3_ENST00000542146.1_5'UTR|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000400111.3_Missense_Mutation_p.G532R	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	701	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GTGGTCTCCCCGTCGGCTGCG	0.537000													8	26					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	58					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715654	101715654	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr10:101715654C>A	ENST00000342239.3	-	4	1668	c.1577G>T	c.(1576-1578)gGt>gTt	p.G526V	DNMBP_ENST00000324109.4_Missense_Mutation_p.G526V|DNMBP-AS1_ENST00000434409.1_RNA			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	526					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GGCTTGCGGACCAGGCTTCAT	0.498000													20	104					1.00905e-13	1.21086e-13	1	1	0
ENPP1	5167	broad.mit.edu	37	6	132194118	132194118	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr6:132194118G>A	ENST00000360971.2	+	15	1513	c.1493G>A	c.(1492-1494)cGt>cAt	p.R498H		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	498	Phosphodiesterase.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTACCTAAGCGTTTGCACTTT	0.408000													71	101					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78430035	78430036	+	Frame_Shift_Ins	INS	-	-	G			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr1:78430035_78430036insG	ENST00000370767.1	-	11	930_931	c.843_844insC	c.(841-846)ccttccfs	p.S282fs	FUBP1_ENST00000436586.2_Frame_Shift_Ins_p.S303fs|FUBP1_ENST00000370768.2_Frame_Shift_Ins_p.S282fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	282	KH 3.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						AATCTTGGAATGGGGACCTTAT	0.342			"""F, N"""		oligodendroglioma								12	23	---	---	---	---					
OR2T35	403244	broad.mit.edu	37	1	248801975	248801976	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr1:248801975_248801976delAT	ENST00000317450.3	-	1	583_584	c.584_585delAT	c.(583-585)tfs	p.Y195fs		NM_001001827.1	NP_001001827.1	Q8NGX2	O2T35_HUMAN	olfactory receptor, family 2, subfamily T, member 35	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	6	all_cancers(71;2.04e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCAGGGTCTCATAGAGTGACGT	0.500													3	6	---	---	---	---					
AC074391.1	0	broad.mit.edu	37	2	65738863	65738863	+	RNA	DEL	G	G	-			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr2:65738863delG	ENST00000377977.3	+	0	862																											TTTTTTTTTTGTCCAGGAGGC	0.303													2	4	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67591129	67591130	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr5:67591129_67591130delAA	ENST00000521381.1	+	13	2338_2339	c.1722_1723delAA	c.(1720-1725)agagfs	p.RK574fs	PIK3R1_ENST00000336483.5_Frame_Shift_Del_p.RK304fs|PIK3R1_ENST00000523872.1_Frame_Shift_Del_p.RK211fs|PIK3R1_ENST00000320694.8_Frame_Shift_Del_p.RK274fs|PIK3R1_ENST00000274335.5_Frame_Shift_Del_p.RK574fs|PIK3R1_ENST00000521657.1_Frame_Shift_Del_p.RK574fs|PIK3R1_ENST00000396611.1_Frame_Shift_Del_p.RK574fs	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	574					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R574_T576del(2)|p.R574fs*27(1)|p.L570_D578del(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCCAGCTGAGAAAGACGAGAGA	0.376			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			10	81	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													5	4	---	---	---	---					
RRN3P1	0	broad.mit.edu	37	16	21817398	21817399	+	RNA	INS	-	-	A	rs144931984	by1000genomes	TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr16:21817398_21817399insA	ENST00000546471.1	-	0	1607																											TAAATGaaaataaaaaaataaa	0.302													5	8	---	---	---	---					
CNOT1	23019	broad.mit.edu	37	16	58589321	58589322	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr16:58589321_58589322insT	ENST00000317147.5	-	21	3056_3057	c.2724_2725insA	c.(2722-2727)aaagttfs	p.V909fs	CNOT1_ENST00000569732.1_5'UTR|CNOT1_ENST00000569240.1_Frame_Shift_Ins_p.V904fs|CNOT1_ENST00000441024.2_Frame_Shift_Ins_p.V909fs	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	909					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATATGTAACTCTTTATCAGGAT	0.376													36	130	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42793116	42793116	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chr19:42793116delT	ENST00000572681.2	+	8	3803	c.3735delT	c.(3733-3735)tgfs	p.C1245fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.C336fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.C336fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	336	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCAGCTCCTGTGGGGCAGAAC	0.622			"""Mis, F, S"""		oligodendroglioma								9	58	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-S9-A7IY-01A-11D-A34A-08	TCGA-S9-A7IY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a9c6d8f4-b65d-45d1-be60-bc2582ca5ece	1630984f-6709-413b-841f-d9798f3bf99a	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			5	1	---	---	---	---