Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR13F1	138805	broad.mit.edu	37	9	107266930	107266930	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr9:107266930C>T	ENST00000334726.2	+	1	476	c.387C>T	c.(385-387)ccC>ccT	p.P129P		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						TCTGCAACCCCCTGAGATACC	0.552000													61	65					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3627984	3627984	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr17:3627984G>A	ENST00000325418.4	+	1	774	c.755G>A	c.(754-756)gGa>gAa	p.G252E	ITGAE_ENST00000571185.1_5'UTR|ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	252					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										ATGAACTCAGGAACCCCTGAG	0.552000													63	76					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	815715	815715	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr16:815715C>T	ENST00000566549.1	+	10	1237	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C	MSLN_ENST00000545450.2_Missense_Mutation_p.R274C|MSLN_ENST00000382862.3_Missense_Mutation_p.R274C|MSLN_ENST00000563941.1_Missense_Mutation_p.R274C			Q13421	MSLN_HUMAN	mesothelin	274	Required for megakaryocyte-potentiating factor activity.				cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GTGGCGGCAACGCTCCTCTCG	0.711000													29	31					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55183906	55183906	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr17:55183906G>A	ENST00000337714.3	+	2	1314	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	AKAP1_ENST00000572557.1_Missense_Mutation_p.E361K|AKAP1_ENST00000314126.3_Missense_Mutation_p.E361K|AKAP1_ENST00000571629.1_Missense_Mutation_p.E361K|AKAP1_ENST00000539273.1_Missense_Mutation_p.E361K	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	361					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					AGAAGCAACCGAACAGGTGCT	0.537000													4	143					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087443	92087443	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:92087443G>A	ENST00000298047.6	+	1	2182	c.2165G>A	c.(2164-2166)gGa>gAa	p.G722E	FAT3_ENST00000409404.2_Missense_Mutation_p.G722E|FAT3_ENST00000525166.1_Missense_Mutation_p.G572E|FAT3_ENST00000541502.1_Missense_Mutation_p.G722E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	722					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATAGACAGGGACCATATTTT	0.398000										TCGA Ovarian(4;0.039)			116	181					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727377	25727377	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr6:25727377C>T	ENST00000274764.2	+	1	241	c.241C>T	c.(241-243)Cgt>Tgt	p.R81C		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	81					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CGAGGCATCACGTTTGGCTCA	0.507000													4	156					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	191					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	587410	587410	+	Silent	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:587410G>A	ENST00000264555.5	+	4	494	c.366G>A	c.(364-366)acG>acA	p.T122T	PHRF1_ENST00000533464.1_Silent_p.T118T|PHRF1_ENST00000416188.2_Silent_p.T122T|PHRF1_ENST00000413872.2_Silent_p.T121T	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	122							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CCGTGGGGACGCCGGAGAACT	0.557000													60	108					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113633	94113633	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:94113633C>T	ENST00000243673.2	-	4	1125	c.954G>A	c.(952-954)aaG>aaA	p.K318K	GPR83_ENST00000539203.2_Silent_p.K276K	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	318						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGCGGATGACCTTGCTGGACA	0.517000													9	194					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72431532	72431532	+	Silent	SNP	A	A	G			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr14:72431532A>G	ENST00000553530.1	+	2	231	c.24A>G	c.(22-24)caA>caG	p.Q8Q	RGS6_ENST00000355512.6_Silent_p.Q8Q|RGS6_ENST00000404301.2_Silent_p.Q8Q|RGS6_ENST00000553525.1_Silent_p.Q8Q|RGS6_ENST00000406236.4_Silent_p.Q8Q|RGS6_ENST00000402788.2_Silent_p.Q8Q|RGS6_ENST00000407322.4_Silent_p.Q8Q|RGS6_ENST00000556437.1_Silent_p.Q8Q|RGS6_ENST00000343854.6_Silent_p.Q8Q|RGS6_ENST00000555571.1_Silent_p.Q8Q	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	8					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CCGGGGATCAAAGAGCAGTGG	0.478000													50	84					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124887093	124887093	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr12:124887093C>T	ENST00000356219.3	-	15	1652	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	NCOR2_ENST00000404621.1_Silent_p.Q498Q|NCOR2_ENST00000404121.2_Silent_p.Q69Q|NCOR2_ENST00000429285.2_Silent_p.Q498Q|NCOR2_ENST00000405201.1_Silent_p.Q499Q|NCOR2_ENST00000397355.1_Silent_p.Q499Q	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.Q499Q(9)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgct	0.617000													3	9					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56181020	56181020	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:56181020C>T	ENST00000450554.2	+	11	2202	c.1243C>T	c.(1243-1245)Cgg>Tgg	p.R415W	CTD-2537I9.12_ENST00000585940.1_RNA|U2AF2_ENST00000590551.1_Missense_Mutation_p.R251W|U2AF2_ENST00000308924.4_Missense_Mutation_p.R419W|CTD-2537I9.12_ENST00000589456.1_RNA	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	419	RRM 3.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGAGATCCCCCGGCCTGTGGA	0.657000													27	17					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185637272	185637272	+	Silent	SNP	T	T	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr3:185637272T>A	ENST00000453386.2	-	7	1010	c.735A>T	c.(733-735)ggA>ggT	p.G245G	TRA2B_ENST00000382191.4_Silent_p.G145G	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	245	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						ctcctcctcctccacctcctc	0.393000													5	124					0	0	1	0	0
MADCAM1	8174	broad.mit.edu	37	19	501762	501762	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:501762A>C	ENST00000587541.1	+	2	958	c.104A>C	c.(103-105)cAg>cCg	p.Q35P	MADCAM1_ENST00000346144.4_Intron|AC005775.2_ENST00000592413.1_RNA|MADCAM1_ENST00000215637.3_Missense_Mutation_p.Q254P|MADCAM1_ENST00000382683.4_Intron			Q13477	MADCA_HUMAN	mucosal vascular addressin cell adhesion molecule 1	254	Ig-like 1.				cell adhesion|immune response|regulation of immune response|signal transduction	integral to membrane|membrane fraction|plasma membrane		p.Q254P(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(10;4.25e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCACCTCCCAGGAGCCTCCC	0.721000													5	47					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890639	32890639	+	RNA	SNP	T	T	C	rs79284655		TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr16:32890639T>C	ENST00000330048.5	-	0	3159					NR_003083.2																						ACCAGCGGCTTGTAGTACACA	0.627000													4	47					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48053616	48053616	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chrX:48053616C>T	ENST00000311798.1	-	5	404	c.352G>A	c.(352-354)Gca>Aca	p.A118T	SSX5_ENST00000376923.1_Missense_Mutation_p.A77T|SSX5_ENST00000347757.1_Missense_Mutation_p.A77T	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TGGAAGTCTGCGACCCGTTTA	0.488000													137	23					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1247990	1247990	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:1247990C>T	ENST00000447027.1	+	4	403	c.345C>T	c.(343-345)aaC>aaT	p.N115N	MUC5B_ENST00000529681.1_Silent_p.N115N			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	115	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGACTTCAACGTCCAGCTAC	0.632000													5	53					0	0	1	0	0
APPL2	55198	broad.mit.edu	37	12	105593272	105593272	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr12:105593272G>A	ENST00000258530.3	-	10	967	c.742C>T	c.(742-744)Cgg>Tgg	p.R248W	APPL2_ENST00000539978.2_Missense_Mutation_p.R205W|APPL2_ENST00000551662.1_Missense_Mutation_p.R254W|APPL2_ENST00000549573.1_5'UTR	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	248	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TGGGACACCCGCATCTTTTCC	0.502000													4	142					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21238368	21238368	+	Missense_Mutation	SNP	G	G	A	rs72653076	byFrequency	TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr2:21238368G>A	ENST00000233242.1	-	22	3509	c.3382C>T	c.(3382-3384)Cgt>Tgt	p.R1128C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1128			R -> H (in dbSNP:rs12713843).		cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTTGCAAACGGGGTATGGAA	0.453000													41	59					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806961	143806961	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr7:143806961T>C	ENST00000408979.2	+	1	355	c.286T>C	c.(286-288)Tgc>Cgc	p.C96R		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CTTTGTTCCATGCATAATGCA	0.433000													5	354					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	69957819	69957819	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:69957819C>T	ENST00000355303.5	+	7	1111	c.806C>T	c.(805-807)aCg>aTg	p.T269M	ANO1_ENST00000538023.1_Missense_Mutation_p.T269M|ANO1_ENST00000398543.2_Missense_Mutation_p.T153M|ANO1_ENST00000316296.5_Missense_Mutation_p.T241M|ANO1_ENST00000530676.1_Missense_Mutation_p.T153M|ANO1_ENST00000531349.1_Missense_Mutation_p.T4M	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	269					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TAAGGCATCACGAGCCTGCTG	0.532000													5	216					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	480554	480554	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr20:480554G>A	ENST00000217244.3	-	5	613	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C	CSNK2A1_ENST00000349736.5_Missense_Mutation_p.R80C|CSNK2A1_ENST00000460062.1_5'UTR|CSNK2A1_ENST00000400227.3_Missense_Mutation_p.R80C|CSNK2A1_ENST00000400217.1_5'UTR	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	80	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TTTATTTCACGCTTAATTTTC	0.343000													5	281					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36962286	36962286	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr5:36962286G>A	ENST00000282516.8	+	6	1019	c.520G>A	c.(520-522)Gtg>Atg	p.V174M	NIPBL_ENST00000448238.2_Missense_Mutation_p.V174M|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	174					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAATAGCCCAGTGCCTAGTCC	0.438000													181	250					0	0	1	0	0
DPY19L2P1	0	broad.mit.edu	37	7	35131480	35131480	+	RNA	SNP	A	A	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr7:35131480A>T	ENST00000436258.1	-	0	1889																											ATCTTCGTAAAGTGGATGATT	0.423000													4	122					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47883203	47883203	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:47883203C>T	ENST00000328771.4	+	14	3292	c.2943C>T	c.(2941-2943)gcC>gcT	p.A981A		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	981						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGGAGGTGGCCACCCTGAGCA	0.662000													4	38					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								71	102					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93719	93719	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr10:93719C>T	ENST00000447903.2	-	4	712	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	TUBB8_ENST00000332708.5_3'UTR|TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Missense_Mutation_p.E205K			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	205					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity	p.E205K(1)		NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TACAGAGCTTCGTTATCTATG	0.537000													8	290					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105573335	105573335	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr6:105573335T>C	ENST00000314641.5	-	4	686	c.470A>G	c.(469-471)aAg>aGg	p.K157R	BVES_ENST00000446408.2_Missense_Mutation_p.K157R|BVES_ENST00000336775.5_Missense_Mutation_p.K157R	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	157					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity	p.K157R(1)		NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				AGTTTGGCCCTTTTTCAAGGT	0.438000													5	378					0	0	1	0	0
TRAF5	7188	broad.mit.edu	37	1	211544684	211544684	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr1:211544684C>T	ENST00000261464.5	+	10	1025	c.971C>T	c.(970-972)gCt>gTt	p.A324V	TRAF5_ENST00000367004.3_Missense_Mutation_p.A324V|TRAF5_ENST00000336184.2_Missense_Mutation_p.A324V|TRAF5_ENST00000427925.2_Missense_Mutation_p.A218V	NM_001033910.2	NP_001029082.1	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	324					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TGGCTAGAAGCTCAAGTGCAT	0.318000													31	98					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42792003	42792003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:42792003G>A	ENST00000572681.2	+	7	3602	c.3534G>A	c.(3532-3534)tgG>tgA	p.W1178*	CIC_ENST00000575354.2_Nonsense_Mutation_p.W269*|CIC_ENST00000160740.3_Nonsense_Mutation_p.W269*			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	269	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				ATTGGAAGTGGTGCAACAAGG	0.632000			"""Mis, F, S"""		oligodendroglioma								15	6					0	0	1	0	0
CTD-2049J23.2	0	broad.mit.edu	37	3	159819357	159819357	+	RNA	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr3:159819357G>A	ENST00000497452.1	-	0	517																											AGAGCCTGAAGCAGAGCATAG	0.453000													6	312					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123517	12123517	+	Silent	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr6:12123517G>A	ENST00000379388.2	+	4	3821	c.3489G>A	c.(3487-3489)caG>caA	p.Q1163Q		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1163					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TTTCTTTCCAGGAGCTGAATA	0.522000													37	62					0	0	1	0	0
MAPK9	5601	broad.mit.edu	37	5	179674427	179674427	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr5:179674427G>A	ENST00000425491.2	-	7	866	c.700C>T	c.(700-702)Cgc>Tgc	p.R234C	MAPK9_ENST00000455781.1_Intron|MAPK9_ENST00000347470.4_Intron|MAPK9_ENST00000539014.1_3'UTR|MAPK9_ENST00000524170.1_Intron|MAPK9_ENST00000452135.2_Intron|MAPK9_ENST00000397072.3_Intron|MAPK9_ENST00000393360.3_Intron|MAPK9_ENST00000343111.6_Intron	NM_001135044.1	NP_001128516.1	P45984	MK09_HUMAN	mitogen-activated protein kinase 9	0	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCAAGGTCGCGGGGAAGGATA	0.502000													4	66					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21997752	21997752	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr12:21997752G>C	ENST00000261200.4	-	25	3193	c.3194C>G	c.(3193-3195)gCc>gGc	p.A1065G	ABCC9_ENST00000345162.2_Missense_Mutation_p.A1029G|ABCC9_ENST00000261201.4_Missense_Mutation_p.A1065G|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1065	ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAGATTTTTGGCAGCTGTGAG	0.398000													7	191					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196229932	196229932	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr3:196229932G>A	ENST00000318037.3	-	1	707	c.113C>T	c.(112-114)cCg>cTg	p.P38L		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	38					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding	p.P38Q(1)		NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CTGGAAGCACGGTTTACACAG	0.582000													5	184					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75877843	75877843	+	Silent	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr10:75877843G>A	ENST00000211998.4	+	22	3415	c.3321G>A	c.(3319-3321)cgG>cgA	p.R1107R	VCL_ENST00000417648.2_Silent_p.R300R|VCL_ENST00000372755.3_Silent_p.R1039R	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	1107	C-terminal tail.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					AGACTGTGCGGGAAGCTGAAG	0.522000													5	268					0	0	1	0	0
GPR18	0	broad.mit.edu	37	13	99907196	99907196	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr13:99907196G>A	ENST00000340807.3	-	3	1487	c.931C>T	c.(931-933)Cgc>Tgc	p.R311C	GPR18_ENST00000397470.2_Missense_Mutation_p.R311C|GPR18_ENST00000397473.2_Missense_Mutation_p.R311C|UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	311						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	CTTTTTCTGCGCATGCTTCGA	0.378000													4	194					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347047	71347047	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr4:71347047T>C	ENST00000413702.1	+	4	874	c.586T>C	c.(586-588)Tct>Cct	p.S196P	MUC7_ENST00000456088.1_Missense_Mutation_p.S196P|MUC7_ENST00000304887.5_Missense_Mutation_p.S196P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	196	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.587000													4	229					0	0	1	0	0
CDC73	79577	broad.mit.edu	37	1	193218979	193218979	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr1:193218979C>T	ENST00000367435.3	+	16	1721	c.1537C>T	c.(1537-1539)Cgg>Tgg	p.R513W	CDC73_ENST00000477868.1_3'UTR	NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	513					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						AGTGTTCTTACGGTTTTGGGA	0.348000													63	106					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934297	4934297	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr16:4934297C>T	ENST00000345988.2	-	22	4448	c.4359G>A	c.(4357-4359)ccG>ccA	p.P1453P	PPL_ENST00000590782.2_Silent_p.P1451P	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1453					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GCGCCTGCTGCGGGTCCTGCT	0.657000													4	251					0	0	1	0	0
SPRY2	10253	broad.mit.edu	37	13	80911840	80911840	+	Translation_Start_Site	SNP	T	T	C			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr13:80911840T>C	ENST00000377102.1	-	2	978	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	SPRY2_ENST00000540649.1_Start_Codon_SNP_p.M1V|SPRY2_ENST00000377104.3_Start_Codon_SNP_p.M1V			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	1					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		CTGGCCTCCATCAGGTCTTGG	0.587000													22	34					0	0	1	0	0
DPAGT1	1798	broad.mit.edu	37	11	118968694	118968694	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:118968694G>A	ENST00000409993.2	-	8	2339	c.788C>T	c.(787-789)gCc>gTc	p.A263V	DPAGT1_ENST00000432443.2_Missense_Mutation_p.A156V|DPAGT1_ENST00000354202.4_Missense_Mutation_p.A263V			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	263					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GCCCACCACGGCAAAGGTCAT	0.532000													5	168					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887129	123887129	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:123887129A>G	ENST00000320891.4	+	1	848	c.848A>G	c.(847-849)aAc>aGc	p.N283S		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CCCCTTCTCAACCCTGTTGTG	0.458000													27	161					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3143689	3143689	+	Missense_Mutation	SNP	G	G	A	rs11542782		TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr10:3143689G>A	ENST00000381075.2	+	6	597	c.373G>A	c.(373-375)Ggg>Agg	p.G125R	PFKP_ENST00000381125.4_Missense_Mutation_p.G133R	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	133					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GAGCCTCACCGGGGCCAACCT	0.667000													8	20					0	0	1	0	0
ZNF366	0	broad.mit.edu	37	5	71756109	71756109	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr5:71756109C>T	ENST00000318442.5	-	2	1705	c.1215G>A	c.(1213-1215)ccG>ccA	p.P405P		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GCAGCTGGCTCGGGTACTGGA	0.597000													37	38					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149679717	149679717	+	Silent	SNP	A	A	G			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr2:149679717A>G	ENST00000435030.1	+	2	506	c.138A>G	c.(136-138)ccA>ccG	p.P46P				O60282	KIF5C_HUMAN	kinesin family member 5C	46	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		AAGGGAAGCCATATGTCTTCG	0.388000													16	35					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97583115	97583115	+	Silent	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr10:97583115C>T	ENST00000371207.3	+	2	237	c.174C>T	c.(172-174)aaC>aaT	p.N58N	ENTPD1_ENST00000371203.5_5'UTR|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000371205.4_Silent_p.N46N|ENTPD1_ENST00000543964.1_Intron|ENTPD1_ENST00000539125.1_5'UTR|ENTPD1_ENST00000453258.2_Silent_p.N53N|ENTPD1_ENST00000490659.1_3'UTR	NM_001164178.1	NP_001157650.1	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	46				SS -> G (in Ref. 8; AA sequence).	cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		TGCCAGAAAACGTTAAGGTAA	0.468000													64	70					0	0	1	0	0
GLYAT	10249	broad.mit.edu	37	11	58477535	58477535	+	Missense_Mutation	SNP	G	G	A	rs138125182		TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr11:58477535G>A	ENST00000344743.3	-	6	736	c.595C>T	c.(595-597)Cgc>Tgc	p.R199C	GLYAT_ENST00000529732.1_Missense_Mutation_p.R199C	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	199					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TGAATGCAGCGCTCAATGAAT	0.502000													69	104					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80195354	80195354	+	Silent	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr17:80195354G>A	ENST00000581287.1	+	3	3030	c.708G>A	c.(706-708)tcG>tcA	p.S236S	SLC16A3_ENST00000582743.1_Silent_p.S236S|SLC16A3_ENST00000392339.1_Silent_p.S236S|SLC16A3_ENST00000392341.1_Silent_p.S236S	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	236					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGGCCGCCTCGGTCATGGTGC	0.716000													16	23					0	0	1	0	0
ASF1B	55723	broad.mit.edu	37	19	14231314	14231314	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:14231314C>A	ENST00000263382.3	-	4	1065	c.566G>T	c.(565-567)tGc>tTc	p.C189F	ASF1B_ENST00000592798.1_Missense_Mutation_p.C130F	NM_018154.2	NP_060624.1	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B histone chaperone	189					cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus				endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7						GCCAGGGATGCAGCCAGGGAG	0.642000													11	52					1.77063e-15	1.80116e-15	1	1	0
PCDHA1	0	broad.mit.edu	37	5	140167257	140167257	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr5:140167257C>T	ENST00000504120.2	+	1	1382	c.1382C>T	c.(1381-1383)aCa>aTa	p.T461I	PCDHA1_ENST00000394633.3_Missense_Mutation_p.T461I|PCDHA1_ENST00000378133.3_Missense_Mutation_p.T461I	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGAGTACACAGTATTCGTG	0.672000													94	132					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122399950	122399950	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr12:122399950C>G	ENST00000288912.4	+	15	3228	c.2374C>G	c.(2374-2376)Cag>Gag	p.Q792E	WDR66_ENST00000545752.1_3'UTR|WDR66_ENST00000397454.2_Missense_Mutation_p.Q792E	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	792							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CCACACCGACCAGGGCTGCTA	0.512000													119	158					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6928249	6928249	+	Silent	SNP	G	G	A			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr19:6928249G>A	ENST00000381404.4	+	16	2190	c.2160G>A	c.(2158-2160)gcG>gcA	p.A720A	EMR1_ENST00000250572.8_Intron|EMR1_ENST00000312053.4_Intron|EMR1_ENST00000450315.3_Intron|EMR1_ENST00000381407.5_Intron	NM_001256252.1	NP_001243181.1	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	763					cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					ACAGCCTGGCGAAGTGTGTTC	0.498000													60	88					0	0	1	0	0
ESPNP	0	broad.mit.edu	37	1	17034125	17034126	+	RNA	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr1:17034125_17034126insAGCT	ENST00000492551.1	-	0	477_478					NR_026567.1																						CAGCAGCAGCCAGCTGAGCACC	0.718													3	3	---	---	---	---					
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr2:242738494_242738496delTCC	ENST00000192314.6	+	2	175_177	c.44_46delTCC	c.(43-48)atc>a	p.IL15del		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	15					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													8	118	---	---	---	---					
GPR149	344758	broad.mit.edu	37	3	154146723	154146727	+	Frame_Shift_Del	DEL	TGGAG	TGGAG	-			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr3:154146723_154146727delTGGAG	ENST00000389740.2	-	1	777_781	c.678_682delCTCCA	c.(676-684)caacfs	p.HSN226fs		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	226						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.S227S(1)		autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCCTGGTAGTTGGAGTGGAGTCTCG	0.595													42	102	---	---	---	---					
KIAA1586	57691	broad.mit.edu	37	6	56918978	56918979	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr6:56918978_56918979insT	ENST00000370733.4	+	4	1888_1889	c.1681_1682insT	c.(1681-1683)aagfs	p.K561fs	KIAA1586_ENST00000545356.1_Frame_Shift_Ins_p.K534fs	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	561							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CAAACGTACCATAAGAGCTTTG	0.267													52	57	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-S9-A6UB-01A-21D-A33T-08	TCGA-S9-A6UB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	365dcb4e-892f-4f2d-ab03-c12d53456e44	f5d9c98d-0660-4659-b8b9-ccd4679de3f4	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													3	4	---	---	---	---