Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNAH3	55567	broad.mit.edu	37	16	21145636	21145636	+	Silent	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr16:21145636C>T	ENST00000261383.3	-	7	1025	c.1026G>A	c.(1024-1026)gaG>gaA	p.E342E	DNAH3_ENST00000415178.1_Silent_p.E342E	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	342	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTGCAGATGCTCCTCGTTCC	0.517000													49	75					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33411115	33411115	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:33411115C>T	ENST00000356990.5	-	5	1260	c.1261_splice	c.e5+1	p.G421_splice	RNF19B_ENST00000235150.4_Splice_Site_p.G421_splice|RNF19B_ENST00000373456.7_Splice_Site_p.G422_splice	NM_001127361.1	NP_001120833.1	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	422						integral to membrane	ligase activity|protein binding|zinc ion binding	p.G231C(1)|p.G421C(1)		endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACTAGCTTACCAACACTAACT	0.463000													12	13					0	0	1	0	0
WDR81	124997	broad.mit.edu	37	17	1636832	1636832	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr17:1636832C>T	ENST00000409644.1	+	7	4501	c.4501C>T	c.(4501-4503)Cgg>Tgg	p.R1501W	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000419248.1_Missense_Mutation_p.R274W|WDR81_ENST00000309182.5_Missense_Mutation_p.R450W|WDR81_ENST00000446363.1_Missense_Mutation_p.R140W|WDR81_ENST00000545662.1_Missense_Mutation_p.R132W|WDR81_ENST00000437219.2_Missense_Mutation_p.R298W	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	274										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGACATCATCCGGAAAATCAT	0.612000													52	94					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42905687	42905687	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:42905687C>T	ENST00000372565.3	-	4	703	c.434G>A	c.(433-435)cGa>cAa	p.R145Q	ZMYND12_ENST00000433602.2_Missense_Mutation_p.R35Q	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	145						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGAACGATTCGGCCCAGACC	0.433000													29	13					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188128	152188128	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:152188128G>A	ENST00000368801.2	-	3	6052	c.5977C>T	c.(5977-5979)Cga>Tga	p.R1993*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1993					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAGACTCTCGGTGACCTAAG	0.572000													8	484					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													3	33					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41268826	41268826	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr3:41268826C>T	ENST00000349496.5	+	7	1344	c.1064C>T	c.(1063-1065)cCg>cTg	p.P355L	CTNNB1_ENST00000396183.3_Missense_Mutation_p.P355L|CTNNB1_ENST00000405570.1_Missense_Mutation_p.P355L|CTNNB1_ENST00000396185.3_Missense_Mutation_p.P355L|CTNNB1_ENST00000453024.1_Missense_Mutation_p.P348L	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	355					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	AGTAATAAGCCGGCTATTGTA	0.378000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				24	35					0	0	1	0	0
GSTA1	2938	broad.mit.edu	37	6	52656723	52656723	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr6:52656723C>T	ENST00000334575.5	-	7	757	c.602G>A	c.(601-603)gGc>gAc	p.G201D	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	201	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	CCTTGGGCTGCCAGGCTGTAG	0.468000													41	72					0	0	1	0	0
CHRNB1	1140	broad.mit.edu	37	17	7350230	7350230	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr17:7350230G>C	ENST00000306071.2	+	4	389	c.322G>C	c.(322-324)Gtg>Ctg	p.V108L	CHRNB1_ENST00000576360.1_Missense_Mutation_p.V36L|CHRNB1_ENST00000536404.2_Missense_Mutation_p.V36L	NM_000747.2	NP_000738.2	P11230	ACHB_HUMAN	cholinergic receptor, nicotinic, beta 1 (muscle)	108					behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(3)	23		Prostate(122;0.157)				GGCGGAATCCGTGTGGCTCCC	0.677000													4	14					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26377303	26377303	+	Silent	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr10:26377303C>T	ENST00000265944.5	+	15	1697	c.1531C>T	c.(1531-1533)Ctg>Ttg	p.L511L	MYO3A_ENST00000543632.1_Silent_p.L511L	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	511	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TGAATATCTCCTGGAAAAATC	0.343000													25	36					0	0	1	0	0
HENMT1	113802	broad.mit.edu	37	1	109193008	109193008	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:109193008G>A	ENST00000370032.5	-	7	1001	c.581C>T	c.(580-582)gCt>gTt	p.A194V	HENMT1_ENST00000370031.1_Missense_Mutation_p.A194V|HENMT1_ENST00000493676.1_5'UTR|HENMT1_ENST00000402983.1_Missense_Mutation_p.A194V	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	194					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						CACATATAAAGCCCTGAAACC	0.413000													21	11					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32476004	32476004	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:32476004C>T	ENST00000404025.2	-	5	1417	c.929G>A	c.(928-930)cGa>cAa	p.R310Q	NLRC4_ENST00000360906.5_Missense_Mutation_p.R310Q|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Missense_Mutation_p.R310Q			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	310	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGCACTTCTCGGATGAGAGC	0.532000													4	66					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113403651	113403651	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr12:113403651C>T	ENST00000228928.7	+	12	2685	c.2506C>T	c.(2506-2508)Cgg>Tgg	p.R836W	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	836	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GGGCAACAAGCGGGCCGAGAT	0.592000													8	11					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28628505	28628505	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr8:28628505C>A	ENST00000416984.2	-	14	1952	c.1593G>T	c.(1591-1593)ttG>ttT	p.L531F	INTS9_ENST00000521777.1_Missense_Mutation_p.L528F|INTS9_ENST00000521022.1_Missense_Mutation_p.L552F|INTS9_ENST00000397363.4_Missense_Mutation_p.L446F	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	552					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CTACCTGAAGCAAGTGCTTGT	0.532000													3	26					1	1	1	1	0
ATP8A1	10396	broad.mit.edu	37	4	42524203	42524203	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr4:42524203C>T	ENST00000381668.5	-	22	2152	c.1921G>A	c.(1921-1923)Gaa>Aaa	p.E641K	ATP8A1_ENST00000264449.10_Missense_Mutation_p.E626K	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	641					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TAACTCTCTTCGAGTTTGAGT	0.428000													3	39					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26196411	26196411	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr8:26196411A>G	ENST00000380737.3	+	3	417	c.88A>G	c.(88-90)Ata>Gta	p.I30V	PPP2R2A_ENST00000523473.1_3'UTR|PPP2R2A_ENST00000315985.7_Missense_Mutation_p.I40V	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TACAGCAGATATAATTTCTAC	0.353000													21	34					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697472	6697472	+	Silent	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr19:6697472C>T	ENST00000245907.6	-	21	2771	c.2679G>A	c.(2677-2679)tcG>tcA	p.S893S		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	893					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GAACGGACAACGAGGACTTGG	0.572000													6	52					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19505646	19505646	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr16:19505646A>C	ENST00000396229.2	+	20	3638	c.2889A>C	c.(2887-2889)aaA>aaC	p.K963N	TMC5_ENST00000564959.1_Missense_Mutation_p.K646N|TMC5_ENST00000561503.1_Missense_Mutation_p.K604N|TMC5_ENST00000542583.2_Missense_Mutation_p.K963N|TMC5_ENST00000541464.1_Missense_Mutation_p.K911N|TMC5_ENST00000381414.4_Missense_Mutation_p.K905N|TMC5_ENST00000219821.5_Missense_Mutation_p.K717N	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	963						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TGGAGAAGAAAGCAAACCCCA	0.458000													8	100					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	46					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142639988	142639988	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr7:142639988C>T	ENST00000355265.2	-	17	2389	c.1915G>A	c.(1915-1917)Gtt>Att	p.V639I		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	639					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AGCCCCCCAACGTCTGCAGCA	0.507000													14	71					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40564858	40564858	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr15:40564858G>A	ENST00000455577.2	+	6	2204	c.1292G>A	c.(1291-1293)cGc>cAc	p.R431H	PAK6_ENST00000560346.1_Missense_Mutation_p.R431H|PAK6_ENST00000260404.4_Missense_Mutation_p.R431H|PAK6_ENST00000453867.1_Missense_Mutation_p.R431H|PAK6_ENST00000542403.2_Missense_Mutation_p.R431H|PAK6_ENST00000441369.1_Missense_Mutation_p.R431H|RP11-133K1.2_ENST00000558658.1_3'UTR	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	431	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CACTCGGGCCGCCAGGTGGCC	0.662000													11	11					0	0	1	0	0
OXGR1	27199	broad.mit.edu	37	13	97639064	97639064	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr13:97639064A>C	ENST00000298440.1	-	4	1193	c.950T>G	c.(949-951)gTg>gGg	p.V317G	OXGR1_ENST00000543457.1_Missense_Mutation_p.V317G	NM_080818.3	NP_543008.3	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	317						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			NS(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TTTGCATCTCACTGTTGAGCA	0.398000													33	62					0	0	1	0	0
TTC30B	150737	broad.mit.edu	37	2	178417025	178417025	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:178417025C>T	ENST00000408939.2	-	1	717	c.467G>A	c.(466-468)gGc>gAc	p.G156D		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	156					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GTTGATCTGGCCATCGGTCTC	0.592000													6	277					0	0	1	0	0
GRM8	0	broad.mit.edu	37	7	126079206	126079206	+	Silent	SNP	T	T	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr7:126079206T>C	ENST00000339582.2	-	11	3502	c.2694A>G	c.(2692-2694)acA>acG	p.T898T	GRM8_ENST00000444921.2_Silent_p.T898T|GRM8_ENST00000358373.3_3'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	898					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGATATATGTTGTCTTGGTAG	0.308000										HNSCC(24;0.065)			48	65					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								25	36					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													5	49					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28925751	28925751	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr16:28925751T>C	ENST00000358201.4	-	5	1288	c.700A>G	c.(700-702)Atc>Gtc	p.I234V	RABEP2_ENST00000544477.1_Missense_Mutation_p.I163V|RABEP2_ENST00000357573.6_Missense_Mutation_p.I234V	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	234					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						AAGGAGGAGATGGAGGCGCTG	0.682000													10	15					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160788073	160788073	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:160788073A>G	ENST00000263285.5	+	6	1438	c.1408A>G	c.(1408-1410)Atc>Gtc	p.I470V	LY9_ENST00000368041.2_Missense_Mutation_p.I340V|LY9_ENST00000368035.1_Missense_Mutation_p.I122V|LY9_ENST00000341032.4_Missense_Mutation_p.I380V|LY9_ENST00000368040.1_Missense_Mutation_p.I122V	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	470					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTGCGTTGGGATCTTCAGCTG	0.478000													5	100					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57087848	57087848	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr11:57087848C>T	ENST00000532437.1	-	2	744	c.433G>A	c.(433-435)Gcc>Acc	p.A145T	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.A145T			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	145	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GGGGCAGGGGCCTTCCGTACA	0.647000													31	47					0	0	1	0	0
HOXA9	3205	broad.mit.edu	37	7	27204770	27204770	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr7:27204770G>C	ENST00000343483.6	-	1	379	c.307C>G	c.(307-309)Ccg>Gcg	p.P103A	RP1-170O19.20_ENST00000465941.1_Intron|HOXA9_ENST00000497089.1_Intron|RP1-170O19.20_ENST00000470747.4_Intron|HOXA9_ENST00000396345.1_Missense_Mutation_p.P103A	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	103							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						CTGCCGTCCGGCGCCGCCGCC	0.711000			T	"""NUP98, MSI2"""	AML*								9	14					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231249985	231249985	+	Silent	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:231249985G>A	ENST00000243810.6	+	9	750	c.750G>A	c.(748-750)gcG>gcA	p.A250A	SP140L_ENST00000444636.1_Silent_p.A250A|SP140L_ENST00000396563.4_Silent_p.A250A|SP140L_ENST00000415673.2_Silent_p.A250A			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	250						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						AAAAGAAGGCGAACATGAATC	0.448000													23	32					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56223200	56223200	+	Silent	SNP	A	A	G	rs149437621	byFrequency	TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr19:56223200A>G	ENST00000332836.2	-	8	2836	c.2809T>C	c.(2809-2811)Ttg>Ctg	p.L937L		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	937						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGGTGGCTCAATGCCTCACAC	0.562000													3	25					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99338034	99338034	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr4:99338034T>C	ENST00000408927.3	+	8	1015	c.902T>C	c.(901-903)cTt>cCt	p.L301P	RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.L302P|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.L252P|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.L210P|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.L253P|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.L302P	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	301							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TTATTACTTCTTGGAGGTGAG	0.348000			T	NUP98	T-ALL								6	90					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67211953	67211953	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr16:67211953C>T	ENST00000290881.7	-	7	2137	c.1211G>A	c.(1210-1212)cGc>cAc	p.R404H	KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R404H|KIAA0895L_ENST00000561679.1_Missense_Mutation_p.R249H|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.A401T			Q68EN5	K895L_HUMAN	KIAA0895-like	404										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GATGGTCTGGCGATGTCGCAG	0.632000													8	15					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67077742	67077742	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr11:67077742A>G	ENST00000308127.4	+	13	1793	c.1615A>G	c.(1615-1617)Agg>Ggg	p.R539G	SSH3_ENST00000308298.7_Intron|SSH3_ENST00000376757.5_3'UTR	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	539					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AGGGGTCATGAGGTCCATCAG	0.617000													4	77					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67433014	67433014	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr11:67433014G>A	ENST00000349015.3	-	7	886	c.448C>T	c.(448-450)Cgc>Tgc	p.R150C	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.R150C	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	150					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase	p.R150C(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CAGGCCACGCGGTTGGCCACG	0.667000													51	131					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088683	42088683	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr20:42088683G>T	ENST00000244020.3	+	4	498	c.392G>T	c.(391-393)cGa>cTa	p.R131L		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	131	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						GATTTTATGCGACAAGCAGGT	0.393000													4	60					0.00909568	0.0092581	1	1	0
ZNF285	26974	broad.mit.edu	37	19	44890648	44890648	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr19:44890648T>C	ENST00000330997.4	-	4	1823	c.1759A>G	c.(1759-1761)Aga>Gga	p.R587G	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000591679.1_Missense_Mutation_p.R594G|ZNF285_ENST00000544719.2_Missense_Mutation_p.R587G	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						AATGTTTCTCTCTGCTCATGT	0.433000													3	32					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42268191	42268191	+	Missense_Mutation	SNP	G	G	A	rs139203660		TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr17:42268191G>A	ENST00000319511.6	+	3	1515	c.865G>A	c.(865-867)Gtc>Atc	p.V289I	TMUB2_ENST00000538716.2_Missense_Mutation_p.V309I|TMUB2_ENST00000589184.1_3'UTR|TMUB2_ENST00000587989.1_Missense_Mutation_p.V309I|TMUB2_ENST00000587172.1_3'UTR|TMUB2_ENST00000446571.3_Missense_Mutation_p.V252I|TMUB2_ENST00000357984.3_Missense_Mutation_p.V289I|TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000589785.1_Missense_Mutation_p.V289I	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	309						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGGAGTCACCGTCTTCTTCAG	0.498000													11	89					0	0	1	0	0
NAT8	9027	broad.mit.edu	37	2	73868602	73868602	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:73868602C>T	ENST00000272425.3	-	2	303	c.154G>A	c.(154-156)Gcc>Acc	p.A52T		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	52					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						AGGAGTAGGGCGAGGGGCCCC	0.612000													38	52					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92730801	92730801	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr7:92730801T>C	ENST00000379958.2	-	3	4879	c.4610A>G	c.(4609-4611)aAt>aGt	p.N1537S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1537						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ATATAAACAATTGTTTTCAGC	0.383000													14	45					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237240097	237240097	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr2:237240097G>A	ENST00000409907.3	-	18	2552	c.2278C>T	c.(2278-2280)Cgg>Tgg	p.R760W	IQCA1_ENST00000309507.5_Missense_Mutation_p.R757W|IQCA1_ENST00000431676.2_Missense_Mutation_p.R719W			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	760							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						ATTTGCCGCCGGATTCTCTGA	0.473000													7	121					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664296	124664296	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr8:124664296C>T	ENST00000325995.7	-	1	894	c.871G>A	c.(871-873)Gga>Aga	p.G291R	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	291										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						TCCTTCCTTCCGCCCAAGAGG	0.542000													15	57					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	82892059	82892059	+	Silent	SNP	G	G	A			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr16:82892059G>A	ENST00000566620.1	+	2	428	c.138G>A	c.(136-138)gaG>gaA	p.E46E	CDH13_ENST00000567445.1_Silent_p.E46E|CDH13_ENST00000431540.3_Silent_p.E46E|CDH13_ENST00000268613.10_Silent_p.E93E|CDH13_ENST00000565636.1_Silent_p.E46E|CDH13_ENST00000428848.3_Silent_p.E46E|CDH13_ENST00000446376.2_Silent_p.E46E	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	46					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AATTCATTGAGGACCAGTCAA	0.393000													3	16					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74000833	74000833	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr4:74000833C>T	ENST00000358602.4	-	16	3351		c.e16+1		ANKRD17_ENST00000330838.6_Splice_Site|ANKRD17_ENST00000509867.2_Splice_Site|ANKRD17_ENST00000514252.1_Splice_Site	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGGGACTTACCTGTGCATCA	0.393000													29	36					0	0	1	0	0
MED8	112950	broad.mit.edu	37	1	43850142	43850143	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:43850142_43850143insT	ENST00000290663.6	-	8	927_928	c.884_885insA	c.(883-885)agcfs	p.S295fs	MED8_ENST00000372457.4_3'UTR	NM_052877.3	NP_443109.2	Q96G25	MED8_HUMAN	mediator complex subunit 8	0					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				endometrium(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	9	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCAGGTGGGCATTTTTTTTTCC	0.510													3	3	---	---	---	---					
FUBP1	8880	broad.mit.edu	37	1	78425910	78425910	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr1:78425910delT	ENST00000370767.1	-	16	1622	c.1535delA	c.(1534-1536)atfs	p.N512fs	FUBP1_ENST00000370768.2_Frame_Shift_Del_p.N512fs|FUBP1_ENST00000436586.2_Frame_Shift_Del_p.N533fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	512	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TGGATATGCATTTCCCCATCC	0.438			"""F, N"""		oligodendroglioma								25	13	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr5:32419951_32419953delGGT	ENST00000265069.8	-	3	495_497	c.393_395delACC	c.(391-396)ccc>cc	p.PP131del		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483													7	186	---	---	---	---					
KIF13A	63971	broad.mit.edu	37	6	17852203	17852203	+	Frame_Shift_Del	DEL	C	C	-			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr6:17852203delC	ENST00000378814.5	-	7	564	c.565delG	c.(565-567)ctfs	p.A189fs	KIF13A_ENST00000378826.2_Frame_Shift_Del_p.A189fs|KIF13A_ENST00000378843.2_Frame_Shift_Del_p.A189fs|KIF13A_ENST00000259711.6_Frame_Shift_Del_p.A189fs|KIF13A_ENST00000378816.5_Frame_Shift_Del_p.A189fs	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	189	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTAGTGACAGCTAGTTGAGAT	0.333													2	4	---	---	---	---					
CCT6P1	0	broad.mit.edu	37	7	65226819	65226819	+	RNA	DEL	A	A	-			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr7:65226819delA	ENST00000442266.1	+	0	1167																											AATGGGGACCAAAAAAAAAAT	0.353													2	4	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42796882	42796883	+	Frame_Shift_Ins	INS	-	-	C			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chr19:42796882_42796883insC	ENST00000572681.2	+	15	6132_6133	c.6064_6065insC	c.(6064-6066)cccfs	p.P2022fs	CIC_ENST00000160740.3_Frame_Shift_Ins_p.P1113fs|CIC_ENST00000575354.2_Frame_Shift_Ins_p.P1114fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.S1117fs*34(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCCATCCCAGGCCCCCCCAAGC	0.683			"""Mis, F, S"""		oligodendroglioma								36	32	---	---	---	---					
ZBTB33	10009	broad.mit.edu	37	X	119389238	119389239	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-S9-A6TX-01A-21D-A32B-08	TCGA-S9-A6TX-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	021bf1e7-5402-4760-8483-90da0f9656f7	c3c498b4-dc24-4a01-979b-e3a01156d4ee	g.chrX:119389238_119389239delTG	ENST00000326624.2	+	2	2196_2197	c.1968_1969delTG	c.(1966-1971)aatafs	p.NV656fs	ZBTB33_ENST00000557385.1_Frame_Shift_Del_p.NV656fs	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	656	Interaction with CTNND1 (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						TTAAACAAAATGTAACAGATGG	0.361													7	50	---	---	---	---