Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	105					0	0	1	0	0
RCBTB1	55213	broad.mit.edu	37	13	50123697	50123697	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr13:50123697C>T	ENST00000378302.2	-	9	1202	c.942G>A	c.(940-942)cgG>cgA	p.R314R	RCBTB1_ENST00000258646.3_Silent_p.R314R|RCBTB1_ENST00000546015.1_Silent_p.R314R	NM_018191.3	NP_060661.3	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	314					cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(1)	16		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		CGGACTGACCCCGGCACTGGC	0.617000													9	49					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155255094	155255094	+	RNA	SNP	T	T	C			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:155255094T>C	ENST00000285718.7	+	0	1399				WASH6P_ENST00000461007.1_RNA																							TGCTCTGACATGGACACAGCC	0.617000													4	12					0	0	1	0	0
KRT40	125115	broad.mit.edu	37	17	39135153	39135153	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr17:39135153G>A	ENST00000377755.4	-	6	1133	c.1099C>T	c.(1099-1101)Cga>Tga	p.R367*	KRT40_ENST00000398486.2_Nonsense_Mutation_p.R367*			Q6A162	K1C40_HUMAN	keratin 40	367	Coil 2.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				TGGTTCTGTCGCTCCAGGTCG	0.617000													4	130					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56792500	56792500	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr16:56792500G>T	ENST00000569842.1	+	3	326	c.230G>T	c.(229-231)cGa>cTa	p.R77L	NUP93_ENST00000308159.5_Missense_Mutation_p.R77L			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	77					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						ATCTCCCAGCGATTGGAGAGT	0.507000													15	57					6.72482e-11	7.33617e-11	1	1	0
PLCXD2	257068	broad.mit.edu	37	3	111394231	111394231	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr3:111394231C>T	ENST00000393934.3	+	1	709	c.139C>T	c.(139-141)Ccc>Tcc	p.P47S	PLCXD2_ENST00000477665.1_Missense_Mutation_p.P47S	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	47	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCACAACCTCCCCCTTTCCAA	0.537000													18	75					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231150512	231150512	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr2:231150512C>T	ENST00000392045.3	+	17	1724	c.1610C>T	c.(1609-1611)gCg>gTg	p.A537V	SP140_ENST00000486687.2_Missense_Mutation_p.A461V|SP140_ENST00000420434.3_Missense_Mutation_p.A510V|SP140_ENST00000417495.3_Missense_Mutation_p.A423V|SP140_ENST00000343805.6_Missense_Mutation_p.A477V|SP140_ENST00000350136.5_Missense_Mutation_p.A406V	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	537					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAAAGAAGGCGAACGTGAAT	0.448000													17	115					0	0	1	0	0
KDELR2	0	broad.mit.edu	37	7	6505884	6505884	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr7:6505884G>A	ENST00000258739.4	-	4	606	c.422C>T	c.(421-423)aCt>aTt	p.T141I	KDELR2_ENST00000490996.1_Intron|DAGLB_ENST00000436575.1_Intron|KDELR2_ENST00000463747.1_Intron	NM_006854.3	NP_006845.1	P33947	ERD22_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	141					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GGCCTCCCCAGTCTTGCTGAT	0.527000													17	69					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19747223	19747223	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:19747223G>T	ENST00000507958.1	-	6	1341	c.351C>A	c.(349-351)gaC>gaA	p.D117E	CDH18_ENST00000511273.1_Missense_Mutation_p.D117E|CDH18_ENST00000506372.1_Missense_Mutation_p.D117E|CDH18_ENST00000502796.1_Missense_Mutation_p.D117E|CDH18_ENST00000274170.4_Missense_Mutation_p.D117E|CDH18_ENST00000382275.1_Missense_Mutation_p.D117E			Q13634	CAD18_HUMAN	cadherin 18, type 2	117	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D117E(2)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCTGCTCTCTGTCTAGGCTTT	0.443000													25	71					1.66031e-10	1.78802e-10	1	1	0
SREBF2	6721	broad.mit.edu	37	22	42266998	42266998	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr22:42266998G>A	ENST00000361204.4	+	4	992	c.826G>A	c.(826-828)Gcc>Acc	p.A276T		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	276	Interaction with LMNA (By similarity).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GGCCCTCACCGCCCTCACCAC	0.577000													50	83					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70287893	70287893	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr16:70287893C>T	ENST00000261772.8	-	18	2592	c.2449G>A	c.(2449-2451)Gag>Aag	p.E817K		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	817					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	TTGAGAGTCTCCCGCAATTCA	0.557000											OREG0023912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	129					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882314	68882314	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr2:68882314C>T	ENST00000303786.3	+	3	1208	c.788C>T	c.(787-789)gCg>gTg	p.A263V	PROKR1_ENST00000394342.2_Missense_Mutation_p.A263V			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	263						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TGGTTCAAGGCGGTCCCTGGA	0.582000													10	38					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130285973	130285973	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr9:130285973G>A	ENST00000373312.3	-	5	787	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	FAM129B_ENST00000373314.3_Missense_Mutation_p.R179W|FAM129B_ENST00000468379.1_Intron	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	192	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTGCAGTGCCGGATGCAGTCC	0.587000											OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	37					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314082	54314082	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr19:54314082C>T	ENST00000324134.6	-	3	999	c.831G>A	c.(829-831)gcG>gcA	p.A277A	NLRP12_ENST00000391773.1_Silent_p.A277A|NLRP12_ENST00000391772.1_Silent_p.A277A|NLRP12_ENST00000535162.1_Silent_p.A277A|NLRP12_ENST00000351894.4_Silent_p.A277A|NLRP12_ENST00000354278.3_Silent_p.A277A|NLRP12_ENST00000391775.3_Silent_p.A277A|NLRP12_ENST00000345770.5_Silent_p.A277A	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	277	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCTGGAGAGGCGCGCTGGGCT	0.557000													13	44					0	0	1	0	0
PCDHGA3	0	broad.mit.edu	37	5	140725053	140725053	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:140725053G>A	ENST00000253812.6	+	1	1453	c.1453G>A	c.(1453-1455)Gcc>Acc	p.A485T	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACAACAACGCCCGCATCAC	0.552000													26	84					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26377316	26377316	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr10:26377316G>A	ENST00000265944.5	+	15	1710	c.1544G>A	c.(1543-1545)cGa>cAa	p.R515Q	MYO3A_ENST00000543632.1_Missense_Mutation_p.R515Q	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	515	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GAAAAATCCCGAGTTATCCAC	0.358000													11	19					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7724586	7724586	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr17:7724586C>T	ENST00000572933.1	+	73	12501	c.11041C>T	c.(11041-11043)Cgc>Tgc	p.R3681C	DNAH2_ENST00000389173.2_Missense_Mutation_p.R3681C			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3681					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTTTTCGAACGCCACAAACT	0.498000													10	97					0	0	1	0	0
TAB3	257397	broad.mit.edu	37	X	30873304	30873304	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:30873304G>T	ENST00000378933.1	-	3	655	c.478C>A	c.(478-480)Cca>Aca	p.P160T	TAB3_ENST00000288422.2_Missense_Mutation_p.P160T|TAB3_ENST00000378930.3_Missense_Mutation_p.P160T|TAB3_ENST00000378932.2_Missense_Mutation_p.P160T	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	160	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						ATGGAAGATGGCTGTTGAGGT	0.478000													33	114					2.47316e-13	2.73349e-13	1	1	0
NANS	54187	broad.mit.edu	37	9	100843119	100843119	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr9:100843119G>T	ENST00000210444.5	+	5	695	c.625G>T	c.(625-627)Gac>Tac	p.D209Y	NANS_ENST00000461452.1_3'UTR|TRIM14_ENST00000375098.3_Intron	NM_018946.3	NP_061819.2	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid synthase	209					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	11		Acute lymphoblastic leukemia(62;0.0559)				GCTCTTTCCTGACATTCCCAT	0.428000													25	75					3.6726e-16	4.11331e-16	1	1	0
RIC8A	60626	broad.mit.edu	37	11	210610	210610	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:210610C>T	ENST00000526104.1	+	4	2110	c.766C>T	c.(766-768)Cgg>Tgg	p.R256W	RIC8A_ENST00000527696.1_Missense_Mutation_p.R250W|RIC8A_ENST00000325207.5_Missense_Mutation_p.R256W			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	256						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GACCCTTCTCCGGCACTGTGT	0.577000													26	90					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121706138	121706138	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr8:121706138C>T	ENST00000395601.3	-	3	996	c.582G>A	c.(580-582)atG>atA	p.M194I	SNTB1_ENST00000517992.1_Missense_Mutation_p.M194I|SNTB1_ENST00000519177.1_5'UTR	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	194	PDZ.|PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGCTTCTCGCATGTACTTCA	0.488000													3	34					0	0	1	0	0
TEKT4P2	0	broad.mit.edu	37	21	9907241	9907241	+	RNA	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr21:9907241C>T	ENST00000416067.1	-	0	1551					NR_037872.1|NR_038327.1																						AGCACCGTGCCGCTGCTCACT	0.572000													5	18					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148632366	148632366	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:148632366G>A	ENST00000506113.1	+	22	2386	c.1904G>A	c.(1903-1905)cGa>cAa	p.R635Q	ABLIM3_ENST00000517451.1_Missense_Mutation_p.R121Q|ABLIM3_ENST00000309868.7_Missense_Mutation_p.R635Q|AC012613.2_ENST00000523176.1_RNA|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000504238.1_Missense_Mutation_p.R524Q|ABLIM3_ENST00000326685.7_Missense_Mutation_p.R540Q|ABLIM3_ENST00000356541.3_Missense_Mutation_p.R524Q|ABLIM3_ENST00000508983.1_Missense_Mutation_p.R602Q|RP11-331K21.1_ENST00000522685.1_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	635	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAAGAAACCGACTGCCCAAG	0.488000													28	110					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33643522	33643522	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr6:33643522C>T	ENST00000374316.5	+	26	4231	c.3171C>T	c.(3169-3171)cgC>cgT	p.R1057R	ITPR3_ENST00000605930.1_Silent_p.R1057R			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1057					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						TGTTCCTGCGCGTGCTCATCC	0.642000													9	27					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1959653	1959653	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr1:1959653G>A	ENST00000378585.4	+	6	696	c.613G>A	c.(613-615)Ggg>Agg	p.G205R		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	205						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GCACATCCACGGGCTGGACAA	0.607000													9	19					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8862382	8862382	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr20:8862382C>T	ENST00000338037.6	+	32	3564	c.3537C>T	c.(3535-3537)caC>caT	p.H1179H	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1179					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ACAGCAATCACGGTTCTGCCC	0.493000													49	140					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100998907	100998907	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:100998907T>C	ENST00000325455.5	-	1	2348	c.895A>G	c.(895-897)Acg>Gcg	p.T299A	PGR_ENST00000534013.1_Intron|PGR_ENST00000263463.5_Missense_Mutation_p.T299A	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	299	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TCCATCACCGTGGTGGCCAGC	0.662000													6	17					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													3	40					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101620772	101620772	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr8:101620772C>T	ENST00000311812.2	-	8	781	c.631G>A	c.(631-633)Gac>Aac	p.D211N	SNX31_ENST00000428383.2_Missense_Mutation_p.D112N	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	211					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			AGCACGGAGTCGAGGGATGGA	0.532000													6	39					0	0	1	0	0
ZDHHC13	54503	broad.mit.edu	37	11	19197407	19197407	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:19197407G>A	ENST00000446113.2	+	17	1890	c.1769G>A	c.(1768-1770)tGt>tAt	p.C590Y	ZDHHC13_ENST00000399351.3_Missense_Mutation_p.C460Y	NM_019028.2	NP_061901.2	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC-type containing 13	590					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						TTCTTTCAGTGTGGCTGCTTT	0.443000													14	44					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7520913	7520913	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:7520913C>T	ENST00000338316.4	+	3	560	c.471C>T	c.(469-471)gaC>gaT	p.D157D		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	157					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.D157D(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						ACATGCGAGACGCCATCATTG	0.547000													5	62					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21484035	21484035	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr18:21484035G>T	ENST00000313654.9	+	50	6698	c.6457G>T	c.(6457-6459)Gca>Tca	p.A2153S	LAMA3_ENST00000269217.6_Missense_Mutation_p.A544S|LAMA3_ENST00000587184.1_Missense_Mutation_p.A488S|LAMA3_ENST00000399516.3_Missense_Mutation_p.A2097S|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2153	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAAGAGCTGGCAAAGCAGCT	0.552000													19	69					2.4624e-09	2.58552e-09	1	1	0
SGSM2	9905	broad.mit.edu	37	17	2268242	2268242	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr17:2268242C>T	ENST00000268989.3	+	10	1229	c.1052C>T	c.(1051-1053)cCg>cTg	p.P351L	SGSM2_ENST00000574563.1_Missense_Mutation_p.P351L|SGSM2_ENST00000426855.2_Missense_Mutation_p.P351L	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	351						intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CAGAGGCCGCCGCTGCATTTC	0.647000													8	26					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845811	107845811	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr4:107845811C>T	ENST00000285311.3	-	3	1125	c.420G>A	c.(418-420)ccG>ccA	p.P140P	DKK2_ENST00000513208.1_Silent_p.P40P|DKK2_ENST00000510463.1_Silent_p.P94P	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	140					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CATCCAGAGCCGGGATGTGAG	0.438000													18	101					0	0	1	0	0
RRM1	6240	broad.mit.edu	37	11	4144500	4144500	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:4144500C>T	ENST00000300738.5	+	12	1410	c.1206C>T	c.(1204-1206)acC>acT	p.T402T	RRM1_ENST00000528470.1_3'UTR|RRM1_ENST00000537197.1_Silent_p.T64T|RRM1_ENST00000534285.1_Silent_p.T180T|RRM1_ENST00000423050.2_Silent_p.T305T	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	402					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	AAACAGGCACCCCGTATATGC	0.463000													14	71					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101911740	101911740	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:101911740G>T	ENST00000537097.1	+	6	3712	c.2899G>T	c.(2899-2901)Gcc>Tcc	p.A967S	GPRASP1_ENST00000361600.5_Missense_Mutation_p.A967S|GPRASP1_ENST00000444152.1_Missense_Mutation_p.A967S|GPRASP1_ENST00000415986.1_Missense_Mutation_p.A967S|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	967	Glu-rich.|OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGAGGAAGGGGCCATTGTTGG	0.483000													8	116					1.12685e-05	1.16859e-05	1	1	0
ZNF135	7694	broad.mit.edu	37	19	58578819	58578819	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr19:58578819G>A	ENST00000506786.1	+	5	1395	c.841G>A	c.(841-843)Gag>Aag	p.E281K	ZNF135_ENST00000439855.2_Missense_Mutation_p.E323K|ZNF135_ENST00000401053.4_Missense_Mutation_p.E347K|ZNF135_ENST00000313434.5_Missense_Mutation_p.E323K|ZNF135_ENST00000511556.1_Missense_Mutation_p.E335K|ZNF135_ENST00000359978.6_Missense_Mutation_p.E335K			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	335					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.E347K(1)|p.E323K(1)		breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		TCACACAGGCGAGAAGCCCTA	0.542000													13	44					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83577004	83577004	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:83577004G>T	ENST00000297977.5	-	10	2077	c.1966C>A	c.(1966-1968)Cct>Act	p.P656T	HDX_ENST00000506585.2_Missense_Mutation_p.P598T|HDX_ENST00000373177.2_Missense_Mutation_p.P656T	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	656						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						AATTCAGGAGGTAAATCTGAC	0.343000													8	16					0.000274275	0.000280965	1	1	0
CSTF2	1478	broad.mit.edu	37	X	100075434	100075434	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:100075434C>T	ENST00000415585.2	+	1	51	c.29C>T	c.(28-30)gCg>gTg	p.A10V	CSTF2_ENST00000486615.1_3'UTR|CSTF2_ENST00000372972.2_Missense_Mutation_p.A10V			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	10					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						AGAGACCCAGCGGTGGATCGT	0.567000													11	41					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392720	124392720	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr10:124392720C>T	ENST00000368909.3	+	49	6130	c.6024C>T	c.(6022-6024)tgC>tgT	p.C2008C	DMBT1_ENST00000344338.3_Silent_p.C1998C|DMBT1_ENST00000338354.3_Silent_p.C2008C|DMBT1_ENST00000359586.6_Silent_p.C728C|DMBT1_ENST00000368956.2_Silent_p.C1380C|DMBT1_ENST00000368955.3_Silent_p.C1998C|DMBT1_ENST00000330163.4_Silent_p.C1380C	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2008	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATTATTCCTGCGGAGGCTTCC	0.478000													15	42					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308370	205308370	+	Missense_Mutation	SNP	G	G	A	rs140745821		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr1:205308370G>A	ENST00000367156.3	-	7	1525	c.709C>T	c.(709-711)Cgg>Tgg	p.R237W	KLHDC8A_ENST00000537168.1_Missense_Mutation_p.R124W|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.R237W|KLHDC8A_ENST00000460687.1_Missense_Mutation_p.R103W|KLHDC8A_ENST00000539253.1_Missense_Mutation_p.R237W	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	237										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TTGGGCTGCCGGTAGAGGCGA	0.597000													11	27					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791273	50791273	+	Missense_Mutation	SNP	T	T	G			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr6:50791273T>G	ENST00000263046.4	+	3	428	c.262T>G	c.(262-264)Tac>Gac	p.Y88D	TFAP2B_ENST00000393655.3_Missense_Mutation_p.Y79D|TFAP2B_ENST00000489228.1_3'UTR			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	79	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					GCCGCTCCCCTACCACCAGAG	0.687000													10	37					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229065	8229065	+	Silent	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr4:8229065G>A	ENST00000539824.1	+	12	1790	c.1416G>A	c.(1414-1416)ggG>ggA	p.G472G	SH3TC1_ENST00000514274.1_3'UTR|SH3TC1_ENST00000245105.3_Silent_p.G548G			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	548							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						AGGCCCGGGGGGCGGCCAAGA	0.697000													5	23					0	0	1	0	0
MAGEB4	4115	broad.mit.edu	37	X	30261033	30261033	+	Missense_Mutation	SNP	C	C	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chrX:30261033C>A	ENST00000378982.2	+	1	977	c.781C>A	c.(781-783)Ccc>Acc	p.P261T		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	261	MAGE.									breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						CCAGCAGGTGCCCAACAGTGA	0.493000													9	54					0.0581538	0.0588544	1	1	0
ABCC9	10060	broad.mit.edu	37	12	22005315	22005315	+	Missense_Mutation	SNP	G	G	A	rs140872303		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr12:22005315G>A	ENST00000261200.4	-	21	2629	c.2630C>T	c.(2629-2631)aCg>aTg	p.T877M	ABCC9_ENST00000261201.4_Missense_Mutation_p.T877M|RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000345162.2_Missense_Mutation_p.T841M	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	877	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTCAGCATGCGTCAGATACTG	0.338000													18	101					0	0	1	0	0
PSMD11	5717	broad.mit.edu	37	17	30807620	30807620	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr17:30807620C>T	ENST00000261712.3	+	13	1503	c.1240C>T	c.(1240-1242)Ctc>Ttc	p.L414F	PSMD11_ENST00000457654.2_Missense_Mutation_p.L414F	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	414					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			AGTGGATTCCCTCTACAACAA	0.498000													3	41					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76028196	76028196	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:76028196A>G	ENST00000319211.4	+	2	411	c.146A>G	c.(145-147)aAt>aGt	p.N49S		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	49					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	AGGAACCCCAATGATAAATAT	0.328000													15	65					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82581401	82581401	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr7:82581401C>T	ENST00000423517.2	-	5	9205	c.8868G>A	c.(8866-8868)caG>caA	p.Q2956Q	PCLO_ENST00000333891.8_Silent_p.Q2956Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2887					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGCAGGCTGCTGTGCTGTGC	0.448000													20	113					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175979598	175979598	+	Splice_Site	SNP	T	T	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr2:175979598T>A	ENST00000264110.2	-	8	746		c.e8-2		ATF2_ENST00000409833.1_Splice_Site|ATF2_ENST00000409437.1_Intron|ATF2_ENST00000392543.2_Intron|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000409635.1_Splice_Site|ATF2_ENST00000345739.5_Splice_Site|ATF2_ENST00000426833.3_Splice_Site|ATF2_ENST00000538946.1_Splice_Site|ATF2_ENST00000392544.1_Splice_Site|ATF2_ENST00000487334.2_Splice_Site	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			TGGTACTTCCTATTTAACAAT	0.373000													21	69					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42774001	42774001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr21:42774001C>T	ENST00000330714.3	+	11	1703	c.1519C>T	c.(1519-1521)Cag>Tag	p.Q507*	MX2_ENST00000496774.1_3'UTR	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	507					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CATCGTGCATCAGTACATCCA	0.458000													11	59					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148718147	148718147	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr7:148718147C>T	ENST00000286091.4	-	2	413	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	61	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			ACTCCATTTTCTTCCTTAACT	0.438000													5	28					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124594347	124594347	+	Silent	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr10:124594347G>A	ENST00000368904.1	-	9	2206	c.1257C>T	c.(1255-1257)aaC>aaT	p.N419N	CUZD1_ENST00000545804.1_Silent_p.N419N|CUZD1_ENST00000392790.1_Silent_p.N419N			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	419	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AAAGAGTTTGGTTCAAATCCA	0.393000													12	12					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272199	164272199	+	Silent	SNP	T	T	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr4:164272199T>A	ENST00000515560.1	+	4	2296	c.774T>A	c.(772-774)acT>acA	p.T258T	NPY5R_ENST00000506953.1_Silent_p.T258T|NPY5R_ENST00000338566.3_Silent_p.T258T			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	258					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TCAACTTAACTCTTCATCCAT	0.373000													8	71					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180376261	180376261	+	Missense_Mutation	SNP	C	C	T	rs145611296		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:180376261C>T	ENST00000231229.4	+	7	1222	c.988C>T	c.(988-990)Cgc>Tgc	p.R330C	BTNL8_ENST00000505126.1_Silent_p.H79H|BTNL8_ENST00000533815.2_Silent_p.H102H|BTNL8_ENST00000340184.4_Silent_p.H286H|BTNL8_ENST00000508408.1_Missense_Mutation_p.R323C|BTNL8_ENST00000400707.3_Silent_p.H161H|BTNL8_ENST00000511704.1_Silent_p.H170H	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	481	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCGGAAACACGCAGGTACCA	0.557000													4	49					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	T	rs121913279		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr3:178952085A>T	ENST00000263967.3	+	21	3297	c.3140A>T	c.(3139-3141)cAt>cTt	p.H1047L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			4	53					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47311780	47311780	+	Silent	SNP	C	C	T	rs141671072		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:47311780C>T	ENST00000342922.4	+	18	3381	c.3024C>T	c.(3022-3024)caC>caT	p.H1008H	MADD_ENST00000407859.3_Silent_p.H985H|MADD_ENST00000406482.1_Silent_p.H965H|MADD_ENST00000402799.1_Silent_p.H965H|MADD_ENST00000395336.3_Silent_p.H1028H|MADD_ENST00000402192.2_Silent_p.H1008H|MADD_ENST00000395344.3_Silent_p.H965H|MADD_ENST00000349238.3_Silent_p.H1028H|MADD_ENST00000311027.5_Silent_p.H1028H	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1028					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CCTATGCCCACGCGGGTCTGG	0.547000													14	46					0	0	1	0	0
EGFL7	51162	broad.mit.edu	37	9	139563048	139563048	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr9:139563048C>T	ENST00000371699.1	+	4	1031	c.120C>T	c.(118-120)gtC>gtT	p.V40V	EGFL7_ENST00000308874.7_Silent_p.V40V|EGFL7_ENST00000406555.3_Silent_p.V40V|EGFL7_ENST00000371698.3_Silent_p.V40V|EGFL7_ENST00000492002.1_3'UTR			Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	40	EMI.				angiogenesis|vasculogenesis		calcium ion binding			kidney(2)|ovary(1)|prostate(2)|urinary_tract(1)	6	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GGGACCCTGTCTCCGAGTCGT	0.677000													26	77					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111074	7111074	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:7111074C>T	ENST00000306904.5	+	1	910	c.723C>T	c.(721-723)cgC>cgT	p.R241R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	241	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACACCCACCGCGATTACGGCC	0.657000													6	29					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21349017	21349017	+	Splice_Site	SNP	G	G	A	rs145594158		TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr22:21349017G>A	ENST00000215739.8	+	15	2144		c.e15+1		LZTR1_ENST00000389355.3_Splice_Site|LZTR1_ENST00000479606.1_Splice_Site	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1						anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CCAACTCAAGGTGTGGGGTGG	0.682000													8	17					0	0	1	0	0
FAM161B	145483	broad.mit.edu	37	14	74404345	74404345	+	Missense_Mutation	SNP	C	C	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr14:74404345C>A	ENST00000286544.3	-	7	2012	c.1814G>T	c.(1813-1815)cGa>cTa	p.R605L	FAM161B_ENST00000534936.1_Missense_Mutation_p.R542L|RP5-1021I20.5_ENST00000555916.1_RNA	NM_152445.2	NP_689658.2			family with sequence similarity 161, member B											breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)	21						TGTTTGTATTCGCTGCTTCAT	0.343000													4	162					0.184627	0.184627	1	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49377238	49377238	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr19:49377238C>T	ENST00000200453.5	+	2	1017	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	250	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CTCCGTGTCCCCCCGATCTTC	0.557000													10	48					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129569084	129569084	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr12:129569084T>C	ENST00000422113.2	-	6	1933	c.1607A>G	c.(1606-1608)aAt>aGt	p.N536S	TMEM132D_ENST00000389441.4_Missense_Mutation_p.N74S	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	536						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTGATCTGATTGAGCTCGGT	0.592000													4	14					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109384118	109384118	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr2:109384118G>A	ENST00000283195.6	+	20	7249	c.7123G>A	c.(7123-7125)Gac>Aac	p.D2375N		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2375	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						GATGAGAAGGGACCAAGTATT	0.353000													55	211					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24193966	24193966	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr3:24193966T>C	ENST00000396671.2	-	6	647	c.299A>G	c.(298-300)tAc>tGc	p.Y100C	THRB_ENST00000416420.1_Missense_Mutation_p.Y100C|THRB_ENST00000280696.5_Missense_Mutation_p.Y115C|THRB_ENST00000356447.4_Missense_Mutation_p.Y100C	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	100	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTTGTCTAAGTAACTGGGGAT	0.443000													9	23					0	0	1	0	0
TMEM171	134285	broad.mit.edu	37	5	72419284	72419284	+	Silent	SNP	C	C	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr5:72419284C>T	ENST00000454765.2	+	2	557	c.84C>T	c.(82-84)ttC>ttT	p.F28F	TMEM171_ENST00000287773.5_Silent_p.F28F			Q8WVE6	TM171_HUMAN	transmembrane protein 171	28						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		TCTTTGTCTTCGGCGCCGTCT	0.577000													5	96					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170038125	170038125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr2:170038125G>T	ENST00000263816.3	-	52	10287	c.10002C>A	c.(10000-10002)taC>taA	p.Y3334*	LRP2_ENST00000461418.1_5'UTR	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3334					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCCAGTAGAGGTACCTGTCAG	0.483000													10	33					2.74318e-10	2.9168e-10	1	1	0
SDHAP1	0	broad.mit.edu	37	3	195701331	195701331	+	RNA	SNP	G	G	A	rs78212497	by1000genomes	TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr3:195701331G>A	ENST00000427841.1	-	0	1493					NR_003264.2																						GTCCAATAGCGAGTTTGCCCC	0.592000													7	105					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58972233	58972233	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr11:58972233G>A	ENST00000227451.3	+	9	1815	c.1711G>A	c.(1711-1713)Gtc>Atc	p.V571I	DTX4_ENST00000532982.1_Missense_Mutation_p.V465I	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	571					Notch signaling pathway	cytoplasm	zinc ion binding	p.V465I(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				GTCAGACACCGTCATCTGGAA	0.532000													5	12					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31388578	31388578	+	Silent	SNP	G	G	A			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr16:31388578G>A	ENST00000268296.4	+	23	2902	c.2781G>A	c.(2779-2781)gtG>gtA	p.V927V	ITGAX_ENST00000562522.1_Silent_p.V927V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	927					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TCTACACTGTGGTTAGCAGGT	0.502000													15	76					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116418604	116418605	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr12:116418604_116418605insT	ENST00000281928.3	-	23	5520_5521	c.5314_5315insA	c.(5314-5316)gggfs	p.G1772fs		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1772					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCCAAATCCCGTGAGGGATTTA	0.450													26	86	---	---	---	---					
SNX29P2	0	broad.mit.edu	37	16	29337651	29337652	+	RNA	INS	-	-	CAGAG	rs140530121	by1000genomes	TCGA-P5-A72U-01A-31D-A32B-08	TCGA-P5-A72U-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e273ac4f-af5a-4671-813b-ce86f784fcbe	393cccc0-b27d-4b08-889c-1d74b31f3ce7	g.chr16:29337651_29337652insCAGAG	ENST00000398878.3	+	0	724																											CCCCGTTCACACCTGTTTCCTC	0.599													4	4	---	---	---	---