Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	118					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38317561	38317561	+	Missense_Mutation	SNP	G	G	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr3:38317561G>T	ENST00000311856.4	+	7	1260	c.1211G>T	c.(1210-1212)tGt>tTt	p.C404F	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	404						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		GGCCTGATGTGTATCATCATC	0.597000													7	6					5.4927e-09	6.12648e-09	1	1	0
PLP1	5354	broad.mit.edu	37	X	103045489	103045489	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chrX:103045489C>T	ENST00000418604.1	+	8	1077	c.797C>T	c.(796-798)gCc>gTc	p.A266V	PLP1_ENST00000361621.2_Missense_Mutation_p.A231V|PLP1_ENST00000303958.2_Missense_Mutation_p.A266V|PLP1_ENST00000466486.1_3'UTR	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	266					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						TACAACTTTGCCGTCCTTAAA	0.488000													4	231					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	53893606	53893606	+	Silent	SNP	T	T	C			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr10:53893606T>C	ENST00000373980.4	+	8	1359	c.942T>C	c.(940-942)gaT>gaC	p.D314D	PRKG1_ENST00000401604.2_Silent_p.D299D|PRKG1_ENST00000373975.2_Silent_p.D17D|PRKG1_ENST00000373985.1_Silent_p.D287D	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	299					actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		ATAGGGAAGATGTGAGAACAG	0.318000													12	19					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	197675	197675	+	Missense_Mutation	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr18:197675A>G	ENST00000261601.6	+	8	745	c.654A>G	c.(652-654)atA>atG	p.I218M	USP14_ENST00000383589.2_Missense_Mutation_p.I172M|USP14_ENST00000582707.1_Missense_Mutation_p.I183M|USP14_ENST00000400266.3_Missense_Mutation_p.I207M	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	218					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				TGGAAGCAATAGAGGATGATT	0.308000													3	39					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171259406	171259406	+	Silent	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr2:171259406C>T	ENST00000334231.6	+	19	2205	c.2205C>T	c.(2203-2205)ttC>ttT	p.F735F	MYO3B_ENST00000408978.4_Silent_p.F726F|MYO3B_ENST00000409044.3_Silent_p.F726F|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	726	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TCTTTGGATTCGAGAATTTTC	0.418000													40	52					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160786485	160786485	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:160786485G>A	ENST00000263285.5	+	5	1204	c.1174G>A	c.(1174-1176)Gtc>Atc	p.V392I	LY9_ENST00000368041.2_Intron|LY9_ENST00000368040.1_Missense_Mutation_p.V44I|LY9_ENST00000341032.4_Intron|LY9_ENST00000368035.1_Missense_Mutation_p.V44I	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	392	Ig-like C2-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GGGAAACACTGTCATGTACAC	0.557000													3	33					0	0	1	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972670	110972670	+	Missense_Mutation	SNP	T	T	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr4:110972670T>G	ENST00000394607.3	-	5	785	c.622A>C	c.(622-624)Atg>Ctg	p.M208L	ELOVL6_ENST00000302274.3_Missense_Mutation_p.M208L			Q9H5J4	ELOV6_HUMAN	ELOVL fatty acid elongase 6	208					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	8				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		ACACAGCCCATCAGCATCTGA	0.522000													18	29					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089879	9089879	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr19:9089879C>T	ENST00000397910.4	-	1	2139	c.1936G>A	c.(1936-1938)Ggt>Agt	p.G646S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	646	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.G646S(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTGGGACACCGTTCGTGGCC	0.562000													32	52					0	0	1	0	0
COX20	116228	broad.mit.edu	37	1	245005361	245005361	+	Splice_Site	SNP	G	G	C			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:245005361G>C	ENST00000411948.2	+	2	550		c.e2+1		COX20_ENST00000366528.3_Splice_Site|COX20_ENST00000498262.1_Splice_Site	NM_198076.4	NP_932342.1	Q5RI15	FA36A_HUMAN	COX20 cytochrome C oxidase assembly factor							integral to membrane											TTGTTCACTAGTGAGTATCTG	0.323000													12	33					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	23					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73827469	73827469	+	Missense_Mutation	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr10:73827469A>G	ENST00000373109.2	-	7	1055	c.611T>C	c.(610-612)cTg>cCg	p.L204P	SPOCK2_ENST00000317376.4_Missense_Mutation_p.L204P|SPOCK2_ENST00000536168.1_Missense_Mutation_p.L204P|SPOCK2_ENST00000460053.1_5'UTR	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	204					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CAGGTCAGCCAGGTCCTGACC	0.612000													4	3					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22390767	22390767	+	Silent	SNP	G	G	A	rs138178541	byFrequency	TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr4:22390767G>A	ENST00000334304.5	-	18	2936	c.2667C>T	c.(2665-2667)tgC>tgT	p.C889C	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	889					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity	p.C889C(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				CAGTTATGCCGCAAACAATGA	0.423000													4	186					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116049184	116049184	+	Silent	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr10:116049184C>T	ENST00000603594.1	+	12	2379	c.2058C>T	c.(2056-2058)atC>atT	p.I686I	VWA2_ENST00000392982.3_Silent_p.I686I	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	686	VWFA 3.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		ATTCCCTGATCCACGTGGCAG	0.627000													14	28					0	0	1	0	0
OR5R1	219479	broad.mit.edu	37	11	56185335	56185335	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr11:56185335G>A	ENST00000312253.1	-	1	373	c.374C>T	c.(373-375)gCc>gTc	p.A125V		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					ACTACAGATGGCGACATAGCA	0.463000													24	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								15	28					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													3	38					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39924150	39924150	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:39924150C>T	ENST00000564288.1	+	90	21961	c.21184C>T	c.(21184-21186)Cgc>Tgc	p.R7062C	MACF1_ENST00000361689.2_Missense_Mutation_p.R5003C|MACF1_ENST00000372915.3_Missense_Mutation_p.R6961C|MACF1_ENST00000289893.4_Missense_Mutation_p.R5505C|MACF1_ENST00000317713.7_Missense_Mutation_p.R5003C|MACF1_ENST00000567887.1_Missense_Mutation_p.R7099C|MACF1_ENST00000539005.1_Missense_Mutation_p.R4873C|MACF1_ENST00000545844.1_Missense_Mutation_p.R5003C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6961	EF-hand 1.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.R5505S(1)|p.R5003S(1)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAGAAATCCCGCAGCGGAGG	0.468000													16	2					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160149454	160149454	+	Silent	SNP	T	T	A			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr3:160149454T>A	ENST00000357388.3	+	21	3589	c.3138T>A	c.(3136-3138)ccT>ccA	p.P1046P	RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000462787.1_Silent_p.P988P|SMC4_ENST00000344722.5_Silent_p.P1046P|SMC4_ENST00000360111.2_Silent_p.P988P|SMC4_ENST00000469762.1_Silent_p.P1021P	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	1046					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CACTGCATCCTATAGAAGATA	0.313000													18	24					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10487787	10487787	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr18:10487787G>A	ENST00000355285.4	+	5	1651	c.1297G>A	c.(1297-1299)Ggg>Agg	p.G433R		NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	433					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		GGATGCCCGGGGGCGCTATCT	0.597000													23	14					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117701762	117701762	+	Silent	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr12:117701762C>T	ENST00000317775.6	-	13	2839	c.2154G>A	c.(2152-2154)acG>acA	p.T718T	NOS1_ENST00000338101.4_Silent_p.T718T|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	718					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCCAGACATGCGTGTTCCAGG	0.592000													3	56					0	0	1	0	0
YWHAB	7529	broad.mit.edu	37	20	43532703	43532703	+	Missense_Mutation	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr20:43532703A>G	ENST00000372839.3	+	4	644	c.370A>G	c.(370-372)Aaa>Gaa	p.K124E	YWHAB_ENST00000479421.1_3'UTR|YWHAB_ENST00000353703.4_Missense_Mutation_p.K124E	NM_003404.3	NP_003395.1	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	124					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			breast(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|urinary_tract(1)	12		Myeloproliferative disorder(115;0.0122)				CTTGAAAATGAAAGGAGATTA	0.328000													22	40					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35801065	35801065	+	Splice_Site	SNP	A	A	G			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr9:35801065A>G	ENST00000342694.2	+	7	1606		c.e7-1			NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)						intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TTTCCCCTTCAGCTCCACTTT	0.507000													43	61					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235364	33235364	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr1:33235364C>T	ENST00000401073.2	+	5	747	c.677C>T	c.(676-678)cCg>cTg	p.P226L	KIAA1522_ENST00000373481.3_Missense_Mutation_p.P178L|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373480.1_Missense_Mutation_p.P167L	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	167										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTGGGACTCCCGCAGCATGTG	0.657000													6	4					0	0	1	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197549	39197549	+	Missense_Mutation	SNP	G	G	C			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr17:39197549G>C	ENST00000306271.4	-	1	164	c.101C>G	c.(100-102)tCc>tGc	p.S34C		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	34			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament		p.S34C(6)		NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCTGGCAGGAGCTGGTCTC	0.612000													4	73					0	0	1	0	0
AC027612.3	0	broad.mit.edu	37	2	91887905	91887906	+	RNA	INS	-	-	T			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr2:91887905_91887906insT	ENST00000436174.1	-	0	540																											GCTATTTTCCATTTTTTTTTTT	0.292													8	29	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													3	4	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	RNA	INS	-	-	T	rs33924686	by1000genomes	TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr11:102738795_102738796insT	ENST00000532855.1	-	0	725_726							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N211fs*20(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													4	8	---	---	---	---					
Z84812.4	0	broad.mit.edu	37	16	81973	81974	+	RNA	INS	-	-	GTCC			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr16:81973_81974insGTCC	ENST00000568710.1	-	0	349																											ATCAGCAGGAGGCCCACCTCGT	0.614													5	11	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-HT-A74L-01A-11D-A32B-08	TCGA-HT-A74L-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a858a98-7ba6-482e-ae4b-0d55b308b392	a88c4c8f-c82c-433b-acae-b00d5623e077	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													4	4	---	---	---	---