Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HECTD4	283450	broad.mit.edu	37	12	112708084	112708084	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:112708084C>T	ENST00000550722.1	-	12	2085	c.1690G>A	c.(1690-1692)Gcc>Acc	p.A564T	HECTD4_ENST00000430131.2_Missense_Mutation_p.A276T|HECTD4_ENST00000377560.5_Missense_Mutation_p.A526T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TTAACCATGGCCTTCTCCATA	0.393000													5	248					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085747	95085747	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr14:95085747G>A	ENST00000553947.1	+	6	1822	c.934G>A	c.(934-936)Gtg>Atg	p.V312M	SERPINA3_ENST00000393080.4_Missense_Mutation_p.V287M|SERPINA3_ENST00000482740.1_Missense_Mutation_p.V69M|SERPINA3_ENST00000393078.3_Missense_Mutation_p.V287M|SERPINA3_ENST00000467132.1_Missense_Mutation_p.V287M|SERPINA3_ENST00000556388.1_Intron			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	287					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GATGGAGGAAGTGGAAGCCAT	0.577000													14	66					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87043729	87043729	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr1:87043729C>T	ENST00000370563.3	+	12	2138	c.2096C>T	c.(2095-2097)gCg>gTg	p.A699V	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	699						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AATAGAGCCGCGTACATACCA	0.403000													19	16					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141038	21141038	+	Missense_Mutation	SNP	A	A	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr9:21141038A>C	ENST00000380229.2	-	1	1106	c.532T>G	c.(532-534)Tca>Gca	p.S178A		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	178					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATGTTTGTTGATAAGAACAAG	0.398000													6	195					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13604541	13604541	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr4:13604541T>C	ENST00000040738.5	-	10	4118	c.3983A>G	c.(3982-3984)cAa>cGa	p.Q1328R		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1328							DNA binding										AGTCAGACTTTGGTTAGGGAG	0.458000													31	142					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	50					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103870460	103870460	+	Silent	SNP	T	T	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr4:103870460T>C	ENST00000296422.7	-	4	477	c.336A>G	c.(334-336)ttA>ttG	p.L112L	SLC9B1_ENST00000394789.3_Silent_p.L112L	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	112						integral to membrane	solute:hydrogen antiporter activity										TAATGAGTTGTAAAATTTTTC	0.348000													5	206					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176016160	176016160	+	Silent	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr5:176016160C>T	ENST00000510636.1	+	22	3259	c.2985C>T	c.(2983-2985)gcC>gcT	p.A995A	CDHR2_ENST00000506348.1_Silent_p.A995A|CDHR2_ENST00000261944.5_Silent_p.A995A	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	995	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CCTCCGAGGCCGACGTGTTCG	0.622000													31	374					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79328944	79328944	+	Silent	SNP	A	A	G	rs115193980	by1000genomes	TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr4:79328944A>G	ENST00000264895.6	+	31	4697	c.4257A>G	c.(4255-4257)gtA>gtG	p.V1419V	FRAS1_ENST00000325942.6_Silent_p.V1419V	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1418					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AAGGCATCGTATGGTACAGGC	0.567000													6	67					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79296448	79296448	+	Silent	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:79296448C>T	ENST00000419573.3	-	16	2467	c.2193G>A	c.(2191-2193)ccG>ccA	p.P731P	RASGRF1_ENST00000394745.3_5'UTR|RASGRF1_ENST00000558480.2_Silent_p.P715P|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	731	N-terminal Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGGTGGCGCGCGGGGACTTGG	0.622000													64	103					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100417218	100417218	+	Missense_Mutation	SNP	C	C	T	rs61735975	byFrequency	TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr7:100417218C>T	ENST00000358173.3	-	6	1726	c.1258G>A	c.(1258-1260)Gtc>Atc	p.V420I	EPHB4_ENST00000477446.1_5'UTR|EPHB4_ENST00000360620.3_Missense_Mutation_p.V420I	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	420	Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity	p.V420I(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TCAAATGGGACGGGCCCCGTG	0.612000													9	219					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122085268	122085268	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr4:122085268C>T	ENST00000454328.1	-	3	240	c.13G>A	c.(13-15)Gta>Ata	p.V5I	TNIP3_ENST00000507879.1_Missense_Mutation_p.V75I|TNIP3_ENST00000509841.1_Missense_Mutation_p.V82I|TNIP3_ENST00000057513.3_Missense_Mutation_p.V5I			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	5										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GTGCCCTGTACAAAATGTGCC	0.398000													6	203					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30414015	30414015	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr22:30414015C>G	ENST00000333027.3	+	16	2102	c.1774C>G	c.(1774-1776)Cca>Gca	p.P592A	CTA-85E5.10_ENST00000429350.1_RNA|MTMR3_ENST00000323630.5_Missense_Mutation_p.P456A|MTMR3_ENST00000406629.1_Missense_Mutation_p.P592A|MTMR3_ENST00000401950.2_Missense_Mutation_p.P592A|MTMR3_ENST00000351488.3_Missense_Mutation_p.P592A	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	592					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CAGCTGTGCACCATACCCAGC	0.632000													12	173					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1743284	1743284	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chrX:1743284G>A	ENST00000381241.3	+	3	566	c.367G>A	c.(367-369)Gcc>Acc	p.A123T	ASMT_ENST00000381229.4_Missense_Mutation_p.A123T|ASMT_ENST00000381233.3_Missense_Mutation_p.A123T	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	123					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTGGCAGACGCCGTGAGGTG	0.677000													7	165					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971193	57971193	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:57971193C>T	ENST00000302592.6	-	1	460	c.461G>A	c.(460-462)gGc>gAc	p.G154D		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				GAGCAAAGTGCCGAACCTGGC	0.488000													5	334					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120776054	120776054	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:120776054G>A	ENST00000527524.2	+	13	1615	c.1328G>A	c.(1327-1329)cGc>cAc	p.R443H	GRIK4_ENST00000438375.2_Missense_Mutation_p.R443H			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	443					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.R443H(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GGCAATGACCGCTACGAGGGC	0.547000													5	408					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180055	124180055	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:124180055G>A	ENST00000357821.2	-	1	678	c.608C>T	c.(607-609)gCg>gTg	p.A203V		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A203V(1)		kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GTTAAACCCCGCAATGATAAA	0.488000													14	47					0	0	1	0	0
CAMKMT	79823	broad.mit.edu	37	2	44993588	44993588	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:44993588C>T	ENST00000378494.3	+	10	826	c.782C>T	c.(781-783)gCc>gTc	p.A261V		NM_024766.3	NP_079042.1	Q7Z624	CMKMT_HUMAN	calmodulin-lysine N-methyltransferase	261						cytoplasm	calmodulin-lysine N-methyltransferase activity			breast(2)|large_intestine(3)|lung(5)	10						ATGGTATTTGCCCCACGCCGA	0.358000													4	150					0	0	1	0	0
HLA-DRB6	0	broad.mit.edu	37	6	32521666	32521666	+	RNA	SNP	T	T	C	rs117454723	by1000genomes	TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr6:32521666T>C	ENST00000411500.1	-	0	817					NR_001298.1																						AACAGCCCTGTCCCAAGGAAG	0.507000													3	48					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058118	114058118	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr3:114058118G>A	ENST00000462705.1	-	12	2562	c.1741C>T	c.(1741-1743)Cgc>Tgc	p.R581C	ZBTB20_ENST00000464560.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000393785.2_Missense_Mutation_p.R581C|ZBTB20_ENST00000357258.3_Missense_Mutation_p.R581C|ZBTB20_ENST00000471418.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000474710.1_Missense_Mutation_p.R654C|ZBTB20_ENST00000481632.1_Missense_Mutation_p.R581C	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CGGTGGAGGCGCATGTGCACG	0.552000													26	289					0	0	1	0	0
RRN3	54700	broad.mit.edu	37	16	15188060	15188060	+	Missense_Mutation	SNP	G	G	A	rs139679899	by1000genomes	TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr16:15188060G>A	ENST00000198767.6	-	1	114	c.31C>T	c.(31-33)Ccg>Tcg	p.P11S	PDXDC1_ENST00000535621.2_Intron|RRN3_ENST00000429751.2_Missense_Mutation_p.P11S|RRN3_ENST00000564131.1_Missense_Mutation_p.P11S|RRN3_ENST00000563559.1_Missense_Mutation_p.P11S	NM_018427.3	NP_060897.3	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	11					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm		p.P11S(3)		NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						GCATCTCCCGGCAAACGCGTG	0.637000													3	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141264436	141264436	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:141264436C>T	ENST00000389484.3	-	53	9421	c.8450G>A	c.(8449-8451)tGc>tAc	p.C2817Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2817	LDL-receptor class A 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTGGGAATGCATACTTTATT	0.383000										TSP Lung(27;0.18)			19	230					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12502322	12502322	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:12502322C>T	ENST00000419318.1	-	4	1543	c.794G>A	c.(793-795)cGa>cAa	p.R265Q	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.R297Q			Q96GE5	ZN799_HUMAN	zinc finger protein 799	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R297Q(1)|p.R84Q(1)		breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TTCGTGTCTTCGAAGGGAAGT	0.423000													15	334					0	0	1	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58191243	58191243	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr3:58191243C>T	ENST00000483681.1	-	5	856	c.275G>A	c.(274-276)cGg>cAg	p.R92Q	DNASE1L3_ENST00000486455.1_Intron|DNASE1L3_ENST00000394549.2_Missense_Mutation_p.R92Q|DNASE1L3_ENST00000318316.3_Missense_Mutation_p.R92Q			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	92					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		TCTTCCAAGCCGAGAGCTAAT	0.378000													6	298					0	0	1	0	0
SDS	10993	broad.mit.edu	37	12	113836598	113836598	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:113836598C>T	ENST00000257549.4	-	4	369	c.247G>A	c.(247-249)Gcc>Acc	p.A83T		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	83					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACGATGGTGGCGGGGACGCCG	0.662000													16	33					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52546660	52546660	+	Splice_Site	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr3:52546660G>A	ENST00000321725.6	+	28	3103		c.e28+1			NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1						cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ATGGCTTAAGGTAGGACAGGG	0.562000													29	136					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42614214	42614214	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:42614214G>A	ENST00000318010.8	+	11	1529	c.1289G>A	c.(1288-1290)cGt>cAt	p.R430H		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	430					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGCAAAAAGCGTAAGGTAAAA	0.423000													3	40					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	114112981	114112981	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:114112981C>T	ENST00000335953.4	+	5	1926	c.1546C>T	c.(1546-1548)Cgc>Tgc	p.R516C	RP11-64D24.2_ENST00000544925.1_RNA|ZBTB16_ENST00000535379.1_3'UTR|ZBTB16_ENST00000392996.2_Missense_Mutation_p.R516C	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	516					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CGCGGGCGTGCGCAGCTACAT	0.627000													27	59					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								8	287					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11141553	11141553	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:11141553A>G	ENST00000358026.2	+	25	3814	c.3530A>G	c.(3529-3531)gAc>gGc	p.D1177G	SMARCA4_ENST00000590574.1_Missense_Mutation_p.D1177G|SMARCA4_ENST00000589677.1_Missense_Mutation_p.D1177G|SMARCA4_ENST00000450717.3_Missense_Mutation_p.D1177G|SMARCA4_ENST00000444061.3_Missense_Mutation_p.D1177G|SMARCA4_ENST00000413806.3_Missense_Mutation_p.D1177G|SMARCA4_ENST00000344626.4_Missense_Mutation_p.D1177G|SMARCA4_ENST00000429416.3_Missense_Mutation_p.D1177G|SMARCA4_ENST00000541122.2_Missense_Mutation_p.D1177G	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1177	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TTTGACAGCGACTGGAATCCT	0.627000			"""F, N, Mis"""		NSCLC								5	26					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79555866	79555866	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr10:79555866G>T	ENST00000372391.2	-	29	5394	c.5389C>A	c.(5389-5391)Cat>Aat	p.H1797N	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Missense_Mutation_p.H1457N	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1797	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACATCGAAATGGCCGCTTCTC	0.522000													6	260					0.00198382	0.00203469	1	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								71	140					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31561248	31561248	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:31561248A>G	ENST00000395934.2	+	3	306	c.299A>G	c.(298-300)aAg>aGg	p.K100R	ELP4_ENST00000379163.5_Missense_Mutation_p.K100R|ELP4_ENST00000350638.5_Missense_Mutation_p.K100R			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	100					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					TTGCTCTTCAAGTATTTCCTG	0.348000													80	230					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3784192	3784192	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:3784192C>T	ENST00000310132.6	-	5	690	c.292G>A	c.(292-294)Ggg>Agg	p.G98R	MATK_ENST00000395040.2_Missense_Mutation_p.G57R|MATK_ENST00000395045.2_Missense_Mutation_p.G99R|MATK_ENST00000585778.1_Missense_Mutation_p.G98R	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	98	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCAGCCCCTCCTGTCCA	0.687000													5	147					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107144431	107144431	+	Splice_Site	SNP	A	A	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:107144431A>G	ENST00000392842.1	+	17	2210		c.e17-1		RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Splice_Site|RFX4_ENST00000229387.5_Splice_Site	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)						transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GATGCATTTTAGATACACGGG	0.423000													6	591					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18529342	18529342	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:18529342G>A	ENST00000336714.3	+	16	2265	c.1833G>A	c.(1831-1833)cgG>cgA	p.R611R	SEC23B_ENST00000262544.2_Silent_p.R611R|SEC23B_ENST00000377465.1_Silent_p.R611R|SEC23B_ENST00000377475.3_Silent_p.R611R	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	611					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						ATTTTGCCCGGCAGGACCTGA	0.463000													5	148					0	0	1	0	0
ACSS2	55902	broad.mit.edu	37	20	33501271	33501271	+	Missense_Mutation	SNP	C	C	T	rs112012777	byFrequency	TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:33501271C>T	ENST00000360596.2	+	4	753	c.542C>T	c.(541-543)gCc>gTc	p.A181V	ACSS2_ENST00000336325.4_Missense_Mutation_p.A131V|ACSS2_ENST00000476922.1_Intron|ACSS2_ENST00000253382.5_Missense_Mutation_p.A181V	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	181					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTGGCATGTGCCCGCATTGGG	0.572000													4	187					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791828	42791828	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:42791828G>A	ENST00000572681.2	+	6	3509	c.3441G>A	c.(3439-3441)tgG>tgA	p.W1147*	CIC_ENST00000160740.3_Nonsense_Mutation_p.W238*|CIC_ENST00000575354.2_Nonsense_Mutation_p.W238*			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	238	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCGAGTGGTGGTATGCCCTGG	0.617000			"""Mis, F, S"""		oligodendroglioma								9	86					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57782005	57782005	+	Silent	SNP	T	T	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:57782005T>C	ENST00000371030.2	+	3	3921	c.3921T>C	c.(3919-3921)agT>agC	p.S1307S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1307						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TGAGAGCCAGTAGACTTCGCA	0.552000													14	417					0	0	1	0	0
LACE1	246269	broad.mit.edu	37	6	108841010	108841010	+	Silent	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr6:108841010C>T	ENST00000368977.4	+	12	1500	c.1314C>T	c.(1312-1314)agC>agT	p.S438S		NM_145315.3	NP_660358.2	Q8WV93	LACE1_HUMAN	lactation elevated 1	438							ATP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		TGGGGCTGAGCCAGGTAGGCG	0.368000													4	161					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228631	47228631	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:47228631G>A	ENST00000391910.3	-	11	1901	c.1451C>T	c.(1450-1452)gCg>gTg	p.A484V	STRN4_ENST00000594357.2_5'UTR|STRN4_ENST00000263280.6_Missense_Mutation_p.A477V|STRN4_ENST00000539396.1_Missense_Mutation_p.A358V			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	477						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		ATCTAGCGCCGCATTCCTGTG	0.597000													5	199					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3015524	3015524	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr4:3015524G>T	ENST00000398052.4	+	8	1053	c.710G>T	c.(709-711)aGa>aTa	p.R237I	GRK4_ENST00000345167.6_Missense_Mutation_p.R205I|GRK4_ENST00000398051.4_Missense_Mutation_p.R205I|GRK4_ENST00000504933.1_Missense_Mutation_p.R237I	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	237	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AATGAGAAAAGAATTCTGGAG	0.398000													15	192					1.49906e-05	1.57796e-05	1	1	0
CDH26	60437	broad.mit.edu	37	20	58571755	58571755	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:58571755A>G	ENST00000348616.4	+	13	2258	c.1958A>G	c.(1957-1959)aAt>aGt	p.N653S	CDH26_ENST00000244049.3_Intron|CDH26_ENST00000497614.1_3'UTR|CDH26_ENST00000350849.6_Intron|CDH26_ENST00000244047.5_Missense_Mutation_p.N653S	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	653					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TCTGTATCCAATGATGAAGGC	0.438000													16	409					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72460091	72460091	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:72460091C>T	ENST00000309731.7	-	5	371	c.358G>A	c.(358-360)Ggc>Agc	p.G120S		NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	120	GRAM.					integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						ATATCCTTGCCAAAGAGGCTG	0.587000													5	159					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060261	35060261	+	Silent	SNP	C	C	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:35060261C>A	ENST00000373913.3	+	3	621	c.141C>A	c.(139-141)ccC>ccA	p.P47P	DLGAP4_ENST00000401952.2_Silent_p.P47P|DLGAP4_ENST00000339266.5_Silent_p.P47P|DLGAP4_ENST00000373907.2_Silent_p.P47P			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	47					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCGCTTCCCCGGGCAGAACA	0.672000													48	68					2.84425e-11	3.07486e-11	1	1	0
EIF4A1	1973	broad.mit.edu	37	17	7480734	7480734	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr17:7480734C>T	ENST00000293831.8	+	7	713	c.697C>T	c.(697-699)Cgg>Tgg	p.R233W	SENP3-EIF4A1_ENST00000579777.1_RNA|EIF4A1_ENST00000577269.1_Missense_Mutation_p.R233W|EIF4A1_ENST00000582746.1_Missense_Mutation_p.R233W	NM_001416.3	NP_001407.1	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A1	233	Helicase ATP-binding.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			NS(1)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	22						GGACCCCATTCGGATTCTTGT	0.532000													43	141					0	0	1	0	0
METTL20	254013	broad.mit.edu	37	12	31814956	31814956	+	Silent	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:31814956C>T	ENST00000357721.3	+	2	284	c.69C>T	c.(67-69)agC>agT	p.S23S	METTL20_ENST00000412352.2_Silent_p.S23S|METTL20_ENST00000395763.3_Silent_p.S23S|METTL20_ENST00000538463.1_Silent_p.S23S|METTL20_ENST00000538391.1_Silent_p.S23S	NM_001135863.1	NP_001129335.1	Q8IXQ9	MET20_HUMAN	methyltransferase like 20	23						cytoplasm	protein methyltransferase activity			lung(2)|stomach(1)	3						CTCTGCGAAGCAGTGGTCTTC	0.517000													5	235					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149359993	149359993	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr5:149359993G>A	ENST00000286298.4	+	3	1105	c.837G>A	c.(835-837)cgG>cgA	p.R279R		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	279			R -> W (in AO2).			integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACCTTCCTCGGACTAATGGTG	0.463000													50	207					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070191	114070191	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr3:114070191G>A	ENST00000462705.1	-	11	1336	c.515C>T	c.(514-516)tCg>tTg	p.S172L	ZBTB20_ENST00000464560.1_Missense_Mutation_p.S172L|ZBTB20_ENST00000393785.2_Missense_Mutation_p.S172L|ZBTB20_ENST00000357258.3_Missense_Mutation_p.S172L|ZBTB20_ENST00000471418.1_Missense_Mutation_p.S172L|ZBTB20_ENST00000474710.1_Missense_Mutation_p.S245L|ZBTB20_ENST00000481632.1_Missense_Mutation_p.S172L	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GTAGAGTGCCGAGTAGATCCT	0.672000													21	126					0	0	1	0	0
FAM169B	283777	broad.mit.edu	37	15	98982908	98982908	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:98982908G>A	ENST00000558256.1	-	7	780	c.531C>T	c.(529-531)gcC>gcT	p.A177A	FAM169B_ENST00000332908.4_Silent_p.A177A	NM_182562.2	NP_872368.2	Q8N8A8	F169B_HUMAN	family with sequence similarity 169, member B	177										large_intestine(3)|lung(3)|urinary_tract(1)	7						CTGCCAGCCCGGCATCCTCCT	0.582000													35	48					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528875	124528875	+	Silent	SNP	C	C	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr9:124528875C>G	ENST00000408936.3	+	9	1745	c.1563C>G	c.(1561-1563)ctC>ctG	p.L521L	DAB2IP_ENST00000309989.1_Silent_p.L397L|DAB2IP_ENST00000259371.2_Silent_p.L493L			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	521	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GCGCCTCCCTCTTCCTGCGCT	0.632000													83	118					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868352	97868352	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr3:97868352G>A	ENST00000437310.1	+	1	183	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCATCATGGGGAATCTTGGTC	0.403000													199	361					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25438381	25438381	+	RNA	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:25438381C>T	ENST00000424208.1	+	0	1240				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						TGGGCACTTCCTGGCACCCTG	0.592000													63	108					0	0	1	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505808	44505808	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr20:44505808G>T	ENST00000255152.2	+	2	820	c.611G>T	c.(610-612)aGc>aTc	p.S204I	ZSWIM3_ENST00000454862.2_Missense_Mutation_p.S198I	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	204							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				GACCGGCTCAGCTTCCAGAGC	0.527000													15	172					2.32078e-09	2.4755e-09	1	1	0
SMC6	79677	broad.mit.edu	37	2	17847757	17847757	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:17847757C>A	ENST00000448223.2	-	27	3360	c.3091G>T	c.(3091-3093)Gac>Tac	p.D1031Y	SMC6_ENST00000351948.4_Missense_Mutation_p.D1031Y|SMC6_ENST00000381272.4_Missense_Mutation_p.D1057Y|SMC6_ENST00000402989.1_Missense_Mutation_p.D1031Y	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	1031					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGTATCAAGTCCATGGCAATT	0.373000													14	88					3.45872e-05	3.59347e-05	1	1	0
IGDCC4	57722	broad.mit.edu	37	15	65682659	65682659	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:65682659C>T	ENST00000352385.2	-	13	2451	c.2242G>A	c.(2242-2244)Gga>Aga	p.G748R		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	748						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						AGGGGTGGTCCCCTCTGGATA	0.498000													38	59					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52516581	52516581	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr13:52516581C>T	ENST00000242839.4	-	15	3509	c.3353G>A	c.(3352-3354)cGc>cAc	p.R1118H	ATP7B_ENST00000417240.2_Missense_Mutation_p.R329H|ATP7B_ENST00000448424.2_Missense_Mutation_p.R1040H|ATP7B_ENST00000400370.3_Missense_Mutation_p.R688H|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400366.3_Missense_Mutation_p.R1007H|ATP7B_ENST00000344297.5_Missense_Mutation_p.R911H|ATP7B_ENST00000418097.2_Missense_Mutation_p.R1053H	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1118					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ACTCAAAGGGCGCTCACTGTG	0.557000									Wilson disease				49	90					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129739660	129739660	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr11:129739660G>A	ENST00000446488.3	-	23	3363	c.3260C>T	c.(3259-3261)aCg>aTg	p.T1087M	NFRKB_ENST00000304521.5_Missense_Mutation_p.T1087M|NFRKB_ENST00000524746.1_Missense_Mutation_p.T1087M|NFRKB_ENST00000524794.1_Missense_Mutation_p.T1112M	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1087					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GATGCGGATCGTGGCAGCTGG	0.592000													4	229					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46998531	46998531	+	Silent	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr19:46998531G>A	ENST00000599531.1	-	1	1224	c.192C>T	c.(190-192)gcC>gcT	p.A64A	PNMAL2_ENST00000594749.1_Intron|AC011484.1_ENST00000377652.3_3'UTR|PNMAL2_ENST00000377655.2_Silent_p.A64A	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	64										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ccaccagggcggcctgggcct	0.627000													99	77					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33518314	33518314	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:33518314G>A	ENST00000404816.2	+	20	3553	c.3200G>A	c.(3199-3201)gGc>gAc	p.G1067D	LTBP1_ENST00000498013.1_3'UTR|LTBP1_ENST00000407925.1_Missense_Mutation_p.G741D|LTBP1_ENST00000354476.3_Missense_Mutation_p.G1068D|LTBP1_ENST00000272273.5_Missense_Mutation_p.G7D|LTBP1_ENST00000390003.4_Missense_Mutation_p.G742D|LTBP1_ENST00000418533.2_Missense_Mutation_p.G741D|LTBP1_ENST00000404525.1_Missense_Mutation_p.G688D|LTBP1_ENST00000402934.1_Missense_Mutation_p.G688D			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1067	EGF-like 8; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGCCACAAAGGCTATACCCGG	0.413000													76	95					0	0	1	0	0
HYKK	123688	broad.mit.edu	37	15	78805580	78805580	+	Silent	SNP	C	C	G			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr15:78805580C>G	ENST00000566332.1	+	2	210	c.150C>G	c.(148-150)gtC>gtG	p.V50V	HYKK_ENST00000569878.1_Silent_p.V50V|HYKK_ENST00000388988.4_Silent_p.V50V|HYKK_ENST00000408962.2_Silent_p.V50V|HYKK_ENST00000360519.3_Silent_p.V50V|HYKK_ENST00000563233.1_Silent_p.V50V					hydroxylysine kinase																		ACTTTCATGTCTACGTTTCAA	0.438000													70	150					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													5	261					0	0	1	0	0
KAL1	3730	broad.mit.edu	37	X	8502385	8502385	+	Silent	SNP	C	C	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chrX:8502385C>A	ENST00000262648.3	-	13	2108	c.1959G>T	c.(1957-1959)ccG>ccT	p.P653P		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	653					axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GTGGGAGCTCCGGCGTCCGGA	0.562000													3	57					1	1	1	1	0
C18orf25	147339	broad.mit.edu	37	18	43833711	43833711	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr18:43833711C>T	ENST00000282059.6	+	4	1321	c.947C>T	c.(946-948)gCg>gTg	p.A316V	C18orf25_ENST00000321319.6_Missense_Mutation_p.A255V	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	316								p.A316V(1)		central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						TCTGGCAATGCGCCACTCAAT	0.408000													5	222					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42821420	42821420	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr6:42821420G>A	ENST00000314073.5	+	8	2166	c.1990G>A	c.(1990-1992)Gca>Aca	p.A664T	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.A664T					GLTSCR1-like																		CTTAGGAACCGCACAACCACA	0.428000													5	182					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677437	149677437	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr5:149677437C>T	ENST00000328668.7	-	2	1629	c.1050G>A	c.(1048-1050)tgG>tgA	p.W350*		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	350						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTCGGGTACCAGTCAGTGA	0.637000													14	86					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220299766	220299766	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr2:220299766delC	ENST00000312358.7	+	1	199	c.67delC	c.(67-69)ccfs	p.P24fs		NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	24					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCGGAGTGCCCCCGAAAAG	0.756													2	4	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr5:24492973delA	ENST00000264463.4	-	10	2084	c.1577delT	c.(1576-1578)tcfs	p.F526fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			8	600	---	---	---	---					
ZNF184	7738	broad.mit.edu	37	6	27420810	27420810	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr6:27420810delT	ENST00000211936.6	-	6	812	c.528delA	c.(526-528)aafs	p.K176fs	ZNF184_ENST00000377419.1_Frame_Shift_Del_p.K176fs	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TTACAGGGCCTTTTTCCCAAC	0.408													7	571	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76082490	76082491	+	RNA	INS	-	-	T	rs141632958		TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:76082490_76082491insT	ENST00000552856.1	-	0	401																											cattctTTTTCTTTTTTTTTTT	0.361													12	12	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr12:121134166_121134168delGAA	ENST00000228506.3	+	5	1125_1127	c.697_699delGAA	c.(697-699)del	p.E238del	MLEC_ENST00000412616.2_In_Frame_Del_p.RK154del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	238	Poly-Glu.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding	p.E233E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gaaagaagaggaagaagaagaag	0.458													10	369	---	---	---	---					
CFL2	1073	broad.mit.edu	37	14	35182753	35182754	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr14:35182753_35182754delTG	ENST00000341223.3	-	2	168_169	c.17_18delCA	c.(16-18)afs	p.T6fs	CFL2_ENST00000298159.6_Frame_Shift_Del_p.T6fs|CFL2_ENST00000556161.1_5'UTR|CFL2_ENST00000555765.1_5'UTR	NM_001243645.1|NM_021914.7	NP_001230574.1|NP_068733.1	Q9Y281	COF2_HUMAN	cofilin 2 (muscle)	6	ADF-H.					cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(3)|endometrium(2)|lung(3)	8	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		CATCATTCACTGTAACTCCAGA	0.332													48	97	---	---	---	---					
RP11-652G5.1	0	broad.mit.edu	37	16	32611806	32611806	+	RNA	DEL	T	T	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chr16:32611806delT	ENST00000562976.1	+	0	135																											gatgtgccagtttttctgtat	0.333													11	56	---	---	---	---					
LONRF3	79836	broad.mit.edu	37	X	118108965	118108965	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DH-A7US-01A-11D-A33T-08	TCGA-DH-A7US-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a94ac1-015a-4f95-be04-1ae1bc582df1	785b4ba0-ae5f-464b-a257-06ff197f176f	g.chrX:118108965delA	ENST00000365713.2	+	1	385	c.222delA	c.(220-222)gcfs	p.A74fs	LONRF3_ENST00000304778.7_Frame_Shift_Del_p.A74fs|LONRF3_ENST00000371628.3_Frame_Shift_Del_p.A74fs			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	74					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						TCACGCAGGCAGACGCCTTGG	0.672													2	4	---	---	---	---