Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C2orf71	388939	broad.mit.edu	37	2	29294843	29294843	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:29294843C>T	ENST00000331664.5	-	1	2284	c.2285G>A	c.(2284-2286)tGc>tAc	p.C762Y		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	762					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GGGCATGATGCAATTCCTGAG	0.527000													36	71					0	0	0.788014	0	0
PSMD1	5707	broad.mit.edu	37	2	231948335	231948335	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:231948335A>G	ENST00000308696.6	+	14	1742	c.1580A>G	c.(1579-1581)cAg>cGg	p.Q527R	PSMD1_ENST00000409643.1_Missense_Mutation_p.Q527R|PSMD1_ENST00000373635.4_Missense_Mutation_p.Q527R	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	527					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	AAAAATGCTCAGGCTATTGAG	0.433000													60	140					0	0	0.870114	0	0
PI4KB	5298	broad.mit.edu	37	1	151274728	151274728	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151274728G>A	ENST00000368875.2	-	8	2183	c.1603C>T	c.(1603-1605)Cga>Tga	p.R535*	PI4KB_ENST00000368872.1_Nonsense_Mutation_p.R508*|PI4KB_ENST00000368873.1_Nonsense_Mutation_p.R523*|PI4KB_ENST00000271657.5_Nonsense_Mutation_p.R535*|PI4KB_ENST00000368874.4_Nonsense_Mutation_p.R508*|PI4KB_ENST00000529142.1_Nonsense_Mutation_p.R191*	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	523					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTGGGTCTCGTTTGAAGGCT	0.547000													37	257					0	0	0.819951	0	0
IPMK	253430	broad.mit.edu	37	10	59956101	59956101	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:59956101A>G	ENST00000373935.3	-	6	1309	c.987T>C	c.(985-987)caT>caC	p.H329H		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	329						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						TCTGACTGTGATGCTTTTTTG	0.388000													45	446					0	0	0.870114	0	0
PGS1	9489	broad.mit.edu	37	17	76388741	76388741	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:76388741A>G	ENST00000262764.6	+	2	354	c.328A>G	c.(328-330)Atg>Gtg	p.M110V	PGS1_ENST00000329897.7_Start_Codon_SNP_p.M1V	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	110					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			TTTCGAGCTCATGAAGGTAAG	0.468000													30	112					0	0	0.750413	0	0
MAST2	23139	broad.mit.edu	37	1	46500672	46500672	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:46500672G>T	ENST00000361297.2	+	29	4614	c.4331G>T	c.(4330-4332)aGg>aTg	p.R1444M	MAST2_ENST00000372008.1_Intron|MAST2_ENST00000372009.2_Missense_Mutation_p.R1254M	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1444					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CTGCCGCCCAGGGAAGTGAGC	0.632000													28	22					6.02846e-25	6.62814e-25	0.779181	1	0
ELL2	22936	broad.mit.edu	37	5	95226808	95226808	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:95226808T>C	ENST00000237853.4	-	10	2109	c.1761_splice	c.e10+1	p.Q587_splice	ELL2_ENST00000431061.2_Splice_Site_p.Q337_splice	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	587					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TCCATTTACCTGATACTCTTT	0.433000													129	290					0	0	0.870114	0	0
KIF5B	3799	broad.mit.edu	37	10	32307245	32307245	+	Splice_Site	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:32307245T>A	ENST00000302418.4	-	22	2895	c.2439_splice	c.e22+1	p.K813_splice	KIF5B_ENST00000493889.1_Intron	NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	813					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				TTACATTACCTTTTTAACTCT	0.373000			T	"""RET, ALK"""	NSCLC								88	158					0	0	0.870114	0	0
GEMIN5	25929	broad.mit.edu	37	5	154268882	154268882	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:154268882T>C	ENST00000285873.7	-	27	4433	c.4359_splice	c.e27+1	p.K1453_splice		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	1453					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AACTCTTACCTTAATGCTCTC	0.378000													53	109					0	0	0.870114	0	0
CCDC91	55297	broad.mit.edu	37	12	28460651	28460651	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:28460651T>C	ENST00000545336.1	+	9	964	c.545T>C	c.(544-546)aTt>aCt	p.I182T	CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000381259.1_Missense_Mutation_p.I182T|CCDC91_ENST00000306172.5_Missense_Mutation_p.I152T|CCDC91_ENST00000381256.1_Missense_Mutation_p.I182T|CCDC91_ENST00000539107.1_Missense_Mutation_p.I182T			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	182					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					CAAGAGGCCATTTCTTTTCAA	0.303000													58	103					0	0	0.870114	0	0
ABLIM2	84448	broad.mit.edu	37	4	8021390	8021390	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:8021390C>T	ENST00000318888.4	-	13	1352	c.481G>A	c.(481-483)Gta>Ata	p.V161I	ABLIM2_ENST00000428004.2_Intron|ABLIM2_ENST00000546334.1_Intron|ABLIM2_ENST00000361581.5_Missense_Mutation_p.V427I|ABLIM2_ENST00000361737.5_Intron|ABLIM2_ENST00000545242.1_Missense_Mutation_p.V427I|ABLIM2_ENST00000296372.8_Missense_Mutation_p.V427I|ABLIM2_ENST00000505872.1_Intron|ABLIM2_ENST00000341937.5_Missense_Mutation_p.V427I|ABLIM2_ENST00000514025.1_Missense_Mutation_p.V161I|ABLIM2_ENST00000407564.3_Intron|ABLIM2_ENST00000447017.2_Missense_Mutation_p.V460I			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	427	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						TTATCTTTTACGCCAGTGTCT	0.468000													29	18					0	0	0.750413	0	0
DHRS4	10901	broad.mit.edu	37	14	24424297	24424297	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:24424297T>G	ENST00000313250.5	+	2	385	c.182T>G	c.(181-183)gTc>gGc	p.V61G	DHRS4_ENST00000558581.1_Missense_Mutation_p.V61G|DHRS4_ENST00000558263.1_Missense_Mutation_p.V61G|DHRS4_ENST00000397073.2_Missense_Mutation_p.V43G|DHRS4_ENST00000543741.2_Missense_Mutation_p.V61G|DHRS4_ENST00000421831.1_Missense_Mutation_p.V43G|DHRS4_ENST00000397074.3_Missense_Mutation_p.V61G|DHRS4_ENST00000397075.3_Missense_Mutation_p.V61G|DHRS4_ENST00000382761.3_Missense_Mutation_p.V43G|DHRS4_ENST00000308178.8_Missense_Mutation_p.V43G|DHRS4_ENST00000559632.1_Missense_Mutation_p.V61G	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4	61						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	CATGTGGTCGTCAGCAGCCGG	0.662000													47	26					0	0	0.870114	0	0
KIF3C	3797	broad.mit.edu	37	2	26203973	26203973	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:26203973C>T	ENST00000264712.3	-	1	1393	c.814G>A	c.(814-816)Ggt>Agt	p.G272S	KIF3C_ENST00000405914.1_Missense_Mutation_p.G272S	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	272	Kinesin-motor.|Poly-Gly.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ccgccaccaccgccaccCGAG	0.627000													9	14					0	0	0.608945	0	0
VWF	7450	broad.mit.edu	37	12	6076653	6076653	+	Splice_Site	SNP	A	A	G	rs112100565		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:6076653A>G	ENST00000261405.5	-	47	8140	c.7887_splice	c.e47+1	p.L2629_splice		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2629	VWFC 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTCTCTTACCAGGGGGCAGGG	0.572000													49	111					0	0	0.870114	0	0
ERBB2	2064	broad.mit.edu	37	17	37882078	37882078	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:37882078C>A	ENST00000406381.2	+	25	3264	c.2754C>A	c.(2752-2754)acC>acA	p.T918T	ERBB2_ENST00000541774.1_Silent_p.T933T|ERBB2_ENST00000584601.1_Silent_p.T918T|ERBB2_ENST00000584450.1_Silent_p.T948T|ERBB2_ENST00000540147.1_Silent_p.T918T|ERBB2_ENST00000269571.5_Silent_p.T948T|ERBB2_ENST00000445658.2_Silent_p.T672T	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	948	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CCATCTGCACCATTGATGTCT	0.612000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			18	41					8.28177e-16	8.88466e-16	0.557998	1	0
NPEPPS	9520	broad.mit.edu	37	17	45669320	45669320	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:45669320A>G	ENST00000322157.4	+	11	1497		c.e11-1		NPEPPS_ENST00000530173.1_Splice_Site|NPEPPS_ENST00000544660.1_Splice_Site|NPEPPS_ENST00000525037.1_Splice_Site	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						ACTGTCTGCCAGGTCAGTGTG	0.413000													7	105					0	0	0.307466	0	0
NCOA3	8202	broad.mit.edu	37	20	46281225	46281225	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:46281225G>A	ENST00000372004.3	+	21	4226	c.4010G>A	c.(4009-4011)gGt>gAt	p.G1337D	NCOA3_ENST00000371997.3_Missense_Mutation_p.G1332D|NCOA3_ENST00000371998.3_Missense_Mutation_p.G1341D|NCOA3_ENST00000341724.6_Missense_Mutation_p.G1267D	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1341					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TCAAGAATGGGTCCCTCCCAG	0.483000													4	135					0	0	0.150653	0	0
DPCD	25911	broad.mit.edu	37	10	103360984	103360984	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:103360984A>G	ENST00000370151.4	+	4	344	c.295A>G	c.(295-297)Aag>Gag	p.K99E	DPCD_ENST00000370148.2_Missense_Mutation_p.K99E|DPCD_ENST00000370147.1_Missense_Mutation_p.K99E	NM_015448.1	NP_056263.1	Q9BVM2	DPCD_HUMAN	deleted in primary ciliary dyskinesia homolog (mouse)	99							protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5						CAAGGACACCAAGATGAGTTT	0.537000													38	91					0	0	0.870114	0	0
NES	10763	broad.mit.edu	37	1	156642564	156642564	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:156642564A>G	ENST00000368223.3	-	4	1548	c.1416T>C	c.(1414-1416)ccT>ccC	p.P472P		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	472	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGAGTGGTCAGGGCTGAGGG	0.617000													72	134					0	0	0.870114	0	0
ATF7IP	55729	broad.mit.edu	37	12	14628904	14628904	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:14628904T>C	ENST00000544627.1	+	11	3285		c.e11+2		ATF7IP_ENST00000540793.1_Splice_Site|ATF7IP_ENST00000543189.1_Splice_Site|ATF7IP_ENST00000536444.1_Splice_Site|ATF7IP_ENST00000261168.4_Splice_Site			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein						DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						CTTCACAAGGTACTTCAATAG	0.363000													24	54					0	0	0.717897	0	0
ZNF727	442319	broad.mit.edu	37	7	63529332	63529332	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:63529332T>C	ENST00000550760.3	+	2	246	c.67T>C	c.(67-69)Tct>Cct	p.S23P	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						ATGCCTGGACTCTGCTCAGCA	0.418000													7	12					0	0	0.307466	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64606329	64606329	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:64606329C>T	ENST00000342711.5	-	8	921	c.922G>A	c.(922-924)Gcc>Acc	p.A308T		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	308	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						AGGTCTTGGGCGCTGGCTGGC	0.662000													15	24					0	0	0.557998	0	0
SPTBN2	6712	broad.mit.edu	37	11	66453855	66453855	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:66453855G>A	ENST00000529997.1	-	35	6952	c.6953C>T	c.(6952-6954)tCg>tTg	p.S2318L	SPTBN2_ENST00000309996.2_Intron|SPTBN2_ENST00000533211.1_Intron			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2318	PH.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						AGAGGAACACGAAGGACAGCT	0.517000													59	127					0	0	0.870114	0	0
NCOA4	8031	broad.mit.edu	37	10	51584973	51584973	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:51584973G>A	ENST00000452682.1	+	9	1372	c.1120G>A	c.(1120-1122)Gtg>Atg	p.V374M	NCOA4_ENST00000443446.1_Missense_Mutation_p.V358M|NCOA4_ENST00000414907.2_Missense_Mutation_p.V192M|NCOA4_ENST00000344348.6_Missense_Mutation_p.V358M|NCOA4_ENST00000374087.4_Missense_Mutation_p.V358M|NCOA4_ENST00000374082.1_Missense_Mutation_p.V358M|NCOA4_ENST00000438493.1_Missense_Mutation_p.V374M|NCOA4_ENST00000430396.2_Missense_Mutation_p.V258M	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	358					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						GCCCAAAGGTGTGGAGATTGA	0.473000			T	RET	papillary thyroid								19	51					0	0	0.539581	0	0
MAP4K4	9448	broad.mit.edu	37	2	102501664	102501664	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:102501664T>A	ENST00000413150.2	+	25	2901	c.2846T>A	c.(2845-2847)aTc>aAc	p.I949N	MAP4K4_ENST00000456652.1_Missense_Mutation_p.I833N|MAP4K4_ENST00000425019.1_Missense_Mutation_p.I1067N|MAP4K4_ENST00000350878.4_Missense_Mutation_p.I1074N|MAP4K4_ENST00000324219.4_Missense_Mutation_p.I1115N|MAP4K4_ENST00000350198.4_Missense_Mutation_p.I953N|MAP4K4_ENST00000347699.4_Missense_Mutation_p.I1034N|MAP4K4_ENST00000302217.5_Missense_Mutation_p.I837N	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	1034	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TATGAAAGAATCAAATTTCTG	0.368000													4	21					0	0	0.184627	0	0
MST1	4485	broad.mit.edu	37	3	49721844	49721844	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:49721844A>G	ENST00000449682.2	-	17	2280	c.1919T>C	c.(1918-1920)gTc>gCc	p.V640A		NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	626	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GTTGGAGATGACATTCAGCAA	0.582000													31	54					0	0	0.788014	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43656464	43656464	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:43656464C>T	ENST00000396976.2	-	4	1473	c.1339G>A	c.(1339-1341)Gag>Aag	p.E447K	ZSCAN29_ENST00000568898.1_Intron|ZSCAN29_ENST00000562072.1_Missense_Mutation_p.E446K|ZSCAN29_ENST00000396972.1_Intron	NM_152455.3	NP_689668.3	Q8IWY8	ZSC29_HUMAN	zinc finger and SCAN domain containing 29	447					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(7)|skin(2)	24		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CATAACCTCTCAGCCACTGCT	0.488000													74	126					0	0	0.870114	0	0
SETD2	29072	broad.mit.edu	37	3	47155460	47155460	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:47155460T>G	ENST00000409792.3	-	5	4663	c.4621A>C	c.(4621-4623)Aat>Cat	p.N1541H		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1541	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AACCGTCTATTGGAACAATAA	0.398000			"""N, F, S, Mis"""		clear cell renal carcinoma								71	67					0	0	0.870114	0	0
ZNF638	27332	broad.mit.edu	37	2	71654527	71654527	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:71654527T>C	ENST00000409544.1	+	24	6158	c.5528T>C	c.(5527-5529)aTt>aCt	p.I1843T	ZNF638_ENST00000409407.1_Missense_Mutation_p.I783T|ZNF638_ENST00000264447.4_Missense_Mutation_p.I1843T|ZNF638_ENST00000355812.3_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1843					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AAAACCATGATTGAAAGACAC	0.343000													35	69					0	0	0.769981	0	0
ANXA5	308	broad.mit.edu	37	4	122604561	122604561	+	Silent	SNP	G	G	T	rs144170580		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:122604561G>T	ENST00000296511.5	-	5	546	c.261C>A	c.(259-261)ccC>ccA	p.P87P	ANXA5_ENST00000509016.1_5'UTR|ANXA5_ENST00000515017.1_Intron|ANXA5_ENST00000501272.2_Silent_p.P27P	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	87					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						AAAGCCGAGAGGGTTTCATCA	0.338000													41	60					4.10826e-27	4.52286e-27	0.870114	1	0
CLCN3	1182	broad.mit.edu	37	4	170625248	170625248	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:170625248T>C	ENST00000513761.1	+	10	2222	c.1663T>C	c.(1663-1665)Tgg>Cgg	p.W555R	CLCN3_ENST00000347613.4_Missense_Mutation_p.W555R|CLCN3_ENST00000504131.2_Missense_Mutation_p.W538R|CLCN3_ENST00000360642.3_Missense_Mutation_p.W528R	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	555					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		TCACCACGACTGGTTTATCTT	0.527000													47	36					0	0	0.870114	0	0
CSRP2	1466	broad.mit.edu	37	12	77257107	77257107	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:77257107A>G	ENST00000311083.5	-	3	253	c.130T>C	c.(130-132)Tta>Cta	p.L44L	CSRP2_ENST00000552330.1_Silent_p.L44L|CSRP2_ENST00000546966.1_Silent_p.L44L|CSRP2_ENST00000547435.1_Silent_p.L44L	NM_001321.1	NP_001312.1	Q16527	CSRP2_HUMAN	cysteine and glycine-rich protein 2	44	LIM zinc-binding 1.				multicellular organismal development	nucleus	zinc ion binding			kidney(1)|large_intestine(4)|ovary(1)|prostate(1)|skin(1)	8						GTGCTATCTAAATTTTTCCTG	0.453000													41	71					0	0	0.819951	0	0
FN3KRP	79672	broad.mit.edu	37	17	80684911	80684911	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:80684911G>A	ENST00000269373.6	+	6	867	c.794G>A	c.(793-795)gGc>gAc	p.G265D	FN3KRP_ENST00000535965.1_Missense_Mutation_p.G215D	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	265				G -> C (in Ref. 4; AAH01458).			kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GCCTACCACGGCAAAATCCCC	0.502000													5	167					0	0	0.184627	0	0
USP50	373509	broad.mit.edu	37	15	50833262	50833262	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:50833262T>C	ENST00000532404.1	-	4	817	c.644A>G	c.(643-645)tAt>tGt	p.Y215C	USP50_ENST00000530218.1_Intron	NM_203494.4	NP_987090.2	E9PP86	E9PP86_HUMAN	ubiquitin specific peptidase 50	215					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(5)	13				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		GGAGCATTCATATTTGGATGG	0.443000													26	44					0	0	0.681144	0	0
GLRA1	2741	broad.mit.edu	37	5	151239530	151239530	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:151239530C>A	ENST00000274576.4	-	4	584	c.292G>T	c.(292-294)Gac>Tac	p.D98Y	GLRA1_ENST00000455880.2_Missense_Mutation_p.D98Y|GLRA1_ENST00000471351.2_5'UTR|GLRA1_ENST00000545569.1_Missense_Mutation_p.D15Y	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	98					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGGCGGGGGTCGTTCCATTGC	0.517000													28	62					1.06801e-11	1.13131e-11	0.740014	1	0
DNAH9	1770	broad.mit.edu	37	17	11550505	11550505	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:11550505T>G	ENST00000262442.3	+	12	2155	c.2087T>G	c.(2086-2088)tTt>tGt	p.F696C	DNAH9_ENST00000454412.2_Missense_Mutation_p.F696C	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	696	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACTATCAACTTTAACCCACAG	0.418000													128	199					0	0	0.870114	0	0
IGFBP7	3490	broad.mit.edu	37	4	57898642	57898642	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:57898642G>A	ENST00000295666.4	-	4	812	c.779C>T	c.(778-780)tCa>tTa	p.S260L	IGFBP7_ENST00000537922.1_Missense_Mutation_p.S260L|IGFBP7_ENST00000512512.1_5'UTR	NM_001553.2	NP_001544.1	Q16270	IBP7_HUMAN	insulin-like growth factor binding protein 7	260	Ig-like C2-type.				cell adhesion|negative regulation of cell proliferation|regulation of cell growth	extracellular space	insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|lung(3)	5	Glioma(25;0.08)|all_neural(26;0.181)				Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATTTTTGCTGATGCTGAAGC	0.373000													58	46					0	0	0.870114	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43973054	43973054	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:43973054C>T	ENST00000282406.4	+	24	3715	c.3605C>T	c.(3604-3606)cCt>cTt	p.P1202L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1202	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GAACAGCAGCCTGGAAAATGT	0.368000													31	52					0	0	0.779181	0	0
ST18	9705	broad.mit.edu	37	8	53030917	53030917	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:53030917A>G	ENST00000276480.7	-	24	3523	c.2840T>C	c.(2839-2841)aTg>aCg	p.M947T		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	947						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AAGTTTCATCATATCTGCTTC	0.303000													47	108					0	0	0.870114	0	0
NFS1	9054	broad.mit.edu	37	20	34262295	34262295	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:34262295C>T	ENST00000374092.4	-	10	1183	c.1113G>A	c.(1111-1113)aaG>aaA	p.K371K	NFS1_ENST00000374085.1_Silent_p.K311K|NFS1_ENST00000397425.1_Silent_p.K311K|NFS1_ENST00000540053.1_Silent_p.K169K|NFS1_ENST00000541387.1_Silent_p.K320K	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	371					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	AGGCAACGTCCTTCAGTGCCA	0.517000													64	127					0	0	0.870114	0	0
DDA1	79016	broad.mit.edu	37	19	17430418	17430418	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:17430418C>T	ENST00000359866.4	+	5	386	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C		NM_024050.5	NP_076955.1	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	88										kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4						CGCACCTCCCCGCAAGGTGGC	0.627000													4	5					0	0	0.184627	0	0
SSPO	23145	broad.mit.edu	37	7	149482799	149482799	+	RNA	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:149482799T>C	ENST00000378016.2	+	0	3215							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCGTGCGTCTGGAGGGCACT	0.617000													3	7					0	0	0.150653	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250117	140250117	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140250117T>C	ENST00000398640.2	+	1	1429	c.1429T>C	c.(1429-1431)Tcg>Ccg	p.S477P	PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCACAGTGTCGGCGCGGGA	0.662000													38	91					0	0	0.870114	0	0
TACC2	10579	broad.mit.edu	37	10	123844471	123844471	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:123844471C>T	ENST00000369005.1	+	4	2796	c.2456C>T	c.(2455-2457)tCc>tTc	p.S819F	TACC2_ENST00000334433.3_Missense_Mutation_p.S819F|TACC2_ENST00000515273.1_Missense_Mutation_p.S819F|TACC2_ENST00000453444.2_Missense_Mutation_p.S819F|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.S819F|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	819						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGAGCTGCATCCGAGTGGCCC	0.582000													31	81					0	0	0.769981	0	0
USP19	10869	broad.mit.edu	37	3	49153190	49153190	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:49153190A>G	ENST00000453664.1	-	11	1941	c.1623T>C	c.(1621-1623)caT>caC	p.H541H	USP19_ENST00000434032.2_Silent_p.H551H|USP19_ENST00000417901.1_Silent_p.H553H|USP19_ENST00000398888.2_Silent_p.H450H|USP19_ENST00000398892.3_Silent_p.H490H|USP19_ENST00000398896.1_Silent_p.H258H|USP19_ENST00000398898.2_Silent_p.H490H	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	450					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TTGGGGTTACATGCTCCATGG	0.582000													36	33					0	0	0.812448	0	0
PEX11B	8799	broad.mit.edu	37	1	145522547	145522547	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:145522547C>T	ENST00000369306.3	+	4	557	c.408C>T	c.(406-408)agC>agT	p.S136S	PEX11B_ENST00000537888.1_Silent_p.S122S	NM_003846.2	NP_003837.1	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	136					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAATTTGAGCCGTGATGCTT	0.448000													98	76					0	0	0.870114	0	0
PAN3	255967	broad.mit.edu	37	13	28794507	28794507	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:28794507T>C	ENST00000399613.1	+	5	455	c.392T>C	c.(391-393)tTa>tCa	p.L131S	PAN3_ENST00000380958.3_Missense_Mutation_p.L331S			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	331	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		ACTGCTGGATTAGCGCCAGGT	0.433000													139	258					0	0	0.870114	0	0
TECTA	7007	broad.mit.edu	37	11	120976644	120976644	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:120976644T>C	ENST00000392793.1	+	3	440	c.169T>C	c.(169-171)Ttc>Ctc	p.F57L	TECTA_ENST00000264037.2_Missense_Mutation_p.F57L			O75443	TECTA_HUMAN	tectorin alpha	57					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCCAGTTTTCTTCTTTGGCGT	0.448000													6	317					0	0	0.248553	0	0
TRAPPC1	58485	broad.mit.edu	37	17	7834023	7834023	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:7834023G>A	ENST00000303731.4	-	4	454	c.339C>T	c.(337-339)ccC>ccT	p.P113P	TRAPPC1_ENST00000540486.1_Silent_p.P113P	NM_021210.4	NP_067033.1	Q9Y5R8	TPPC1_HUMAN	trafficking protein particle complex 1	113					ER to Golgi vesicle-mediated transport	endoplasmic reticulum				breast(1)|lung(2)	3		Prostate(122;0.173)				GCGGGCACAGGGGATTCTTCA	0.537000													37	76					0	0	0.796494	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539704	94539704	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:94539704T>C	ENST00000289495.5	+	1	495	c.279T>C	c.(277-279)caT>caC	p.H93H	PPP1R9A_ENST00000340694.4_Silent_p.H93H|PPP1R9A_ENST00000424654.1_Silent_p.H93H|PPP1R9A_ENST00000433881.1_Silent_p.H93H|PPP1R9A_ENST00000456331.2_Silent_p.H93H|PPP1R9A_ENST00000433360.1_Silent_p.H93H	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	93	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGGTGGACATTCATCTCCTC	0.408000										HNSCC(28;0.073)			43	66					0	0	0.840704	0	0
CLK4	57396	broad.mit.edu	37	5	178044364	178044364	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:178044364T>C	ENST00000316308.4	-	4	624	c.456A>G	c.(454-456)ggA>ggG	p.G152G	CLK4_ENST00000522749.1_Intron	NM_020666.2	NP_065717.1	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	152						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(2)	21	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		TTAGAACGTCTCCACTTTGAC	0.418000													34	88					0	0	0.796494	0	0
TTC39C	125488	broad.mit.edu	37	18	21710336	21710336	+	Silent	SNP	G	G	A	rs149403354	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:21710336G>A	ENST00000540918.2	+	7	907	c.657G>A	c.(655-657)ccG>ccA	p.P219P	TTC39C_ENST00000304621.6_Silent_p.P465P|TTC39C_ENST00000317571.3_Silent_p.P526P			Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C	526							binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	19						ATGTTCAGCCGTATGCCTGTT	0.308000													96	180					0	0	0.870114	0	0
USP43	124739	broad.mit.edu	37	17	9583621	9583621	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:9583621C>T	ENST00000570827.2	+	6	1184	c.110C>T	c.(109-111)gCa>gTa	p.A37V	USP43_ENST00000575346.1_3'UTR|USP43_ENST00000570475.1_Missense_Mutation_p.A348V|USP43_ENST00000285199.6_Missense_Mutation_p.A348V			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	348					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						AATACCATCGCAGAGGGAGAT	0.453000													53	136					0	0	0.870114	0	0
CRHR2	1395	broad.mit.edu	37	7	30702345	30702345	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:30702345C>T	ENST00000471646.1	-	6	1079	c.662G>A	c.(661-663)cGc>cAc	p.R221H	CRHR2_ENST00000348438.4_Missense_Mutation_p.R248H|CRHR2_ENST00000341843.4_Missense_Mutation_p.R207H|CRHR2_ENST00000506074.2_Missense_Mutation_p.R221H	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	221					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTGCGCAGGCGCTCAGTGGA	0.567000													20	48					0	0	0.592651	0	0
TAGLN3	29114	broad.mit.edu	37	3	111719762	111719762	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:111719762C>A	ENST00000393917.2	+	3	876	c.324C>A	c.(322-324)acC>acA	p.T108T	TAGLN3_ENST00000486460.1_Silent_p.T24T|TAGLN3_ENST00000478951.1_Silent_p.T108T|TAGLN3_ENST00000455401.2_Silent_p.T108T|TAGLN3_ENST00000273368.4_Silent_p.T108T	NM_013259.2	NP_037391.2	Q9UI15	TAGL3_HUMAN	transgelin 3	108	CH.				central nervous system development|muscle organ development					endometrium(2)|lung(5)|urinary_tract(1)	8						TCAGAACCACCGACATCTTTC	0.478000													109	208					3.26371e-31	3.62156e-31	0.870114	1	0
PASD1	139135	broad.mit.edu	37	X	150780186	150780186	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:150780186T>C	ENST00000370357.4	+	4	413	c.168T>C	c.(166-168)tgT>tgC	p.C56C		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	56	PAS.					nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					TGATCATTTGTGTGGCTGAAA	0.333000													33	195					0	0	0.779181	0	0
LENG8	114823	broad.mit.edu	37	19	54967841	54967841	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:54967841G>A	ENST00000326764.5	+	11	1951	c.1472G>A	c.(1471-1473)aGt>aAt	p.S491N	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	454							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		ACCAAGCGCAGTCGAAAGAAG	0.672000													6	11					0	0	0.217242	0	0
NOX1	27035	broad.mit.edu	37	X	100103736	100103736	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:100103736T>C	ENST00000372966.3	-	12	1656	c.1451A>G	c.(1450-1452)cAt>cGt	p.H484R	NOX1_ENST00000372964.1_Intron|NOX1_ENST00000372960.4_Missense_Mutation_p.H447R|NOX1_ENST00000217885.5_Missense_Mutation_p.H435R	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	484	Interaction with NOXO1.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						TAATGCTGCATGACCAACCTG	0.468000													4	137					0	0	0.184627	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444095	5444095	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:5444095T>C	ENST00000300778.4	+	1	755	c.665T>C	c.(664-666)cTt>cCt	p.L222P	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTATACACTTATTCTGAAA	0.488000													82	205					0	0	0.870114	0	0
PTPRT	11122	broad.mit.edu	37	20	41306678	41306678	+	Nonsense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:41306678A>T	ENST00000373198.3	-	7	1216	c.981T>A	c.(979-981)taT>taA	p.Y327*	PTPRT_ENST00000373201.1_Nonsense_Mutation_p.Y327*|PTPRT_ENST00000373190.1_Nonsense_Mutation_p.Y327*|PTPRT_ENST00000373193.3_Nonsense_Mutation_p.Y327*|PTPRT_ENST00000373187.1_Nonsense_Mutation_p.Y327*|PTPRT_ENST00000373184.1_Nonsense_Mutation_p.Y327*|PTPRT_ENST00000356100.2_Nonsense_Mutation_p.Y327*	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	327	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGTGGTGCGATATTCCACTT	0.567000													59	107					0	0	0.870114	0	0
C10orf137	26098	broad.mit.edu	37	10	127418877	127418877	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:127418877A>T	ENST00000337623.3	+	8	1040	c.935A>T	c.(934-936)aAt>aTt	p.N312I	C10orf137_ENST00000356792.4_Missense_Mutation_p.N346I	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAACCAATTAATGTGCTAACT	0.308000													80	159					0	0	0.870114	0	0
RIPK2	8767	broad.mit.edu	37	8	90784903	90784903	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:90784903A>G	ENST00000220751.4	+	6	1014	c.700A>G	c.(700-702)Aat>Gat	p.N234D	RIPK2_ENST00000540020.1_Missense_Mutation_p.N97D	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	234	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			AGATGTCACCAATCCTTTGCA	0.313000													53	98					0	0	0.870114	0	0
GYS1	2997	broad.mit.edu	37	19	49490600	49490600	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:49490600C>T	ENST00000323798.3	-	3	539	c.343G>A	c.(343-345)Gtg>Atg	p.V115M	GYS1_ENST00000263276.6_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000540532.1_Missense_Mutation_p.V35M|GYS1_ENST00000541188.1_Missense_Mutation_p.V35M|GYS1_ENST00000544287.1_Intron	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	115					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TCCAGGAGCACCACCAGAGGG	0.642000													7	21					0	0	0.307466	0	0
VARS	7407	broad.mit.edu	37	6	31760034	31760034	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:31760034G>A	ENST00000375663.3	-	6	1271	c.831C>T	c.(829-831)gtC>gtT	p.V277V	VARS_ENST00000444930.2_5'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	277					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	CATAGGTAATGACCCCAGGAT	0.552000													52	88					0	0	0.870114	0	0
ARSG	22901	broad.mit.edu	37	17	66397567	66397567	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:66397567C>T	ENST00000448504.2	+	11	2075	c.1279C>T	c.(1279-1281)Cgt>Tgt	p.R427C	ARSG_ENST00000582154.1_3'UTR|ARSG_ENST00000452479.2_Missense_Mutation_p.R263C	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	427					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCGCCTGGAGCGTTACAAGGC	0.592000													29	71					0	0	0.717897	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868726	31868726	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:31868726G>A	ENST00000375527.2	-	2	532	c.357C>T	c.(355-357)tgC>tgT	p.C119C	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						GGGCATTCCGGCATTTCTCCA	0.567000													15	83					0	0	0.500413	0	0
XIST	7503	broad.mit.edu	37	X	73069443	73069443	+	RNA	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:73069443G>A	ENST00000429829.1	-	0	3145					NR_001564.2																						TAACTTCAACGTACCGAGTAA	0.403000													37	28					0	0	0.788014	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529517	5529517	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:5529517A>G	ENST00000311659.4	-	2	1419	c.1272T>C	c.(1270-1272)ggT>ggC	p.G424G	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	424										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTGGTCTCCACCTTGTCCAG	0.547000													71	128					0	0	0.870114	0	0
ITGA5	3678	broad.mit.edu	37	12	54797504	54797504	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:54797504G>A	ENST00000293379.4	-	17	1942	c.1681C>T	c.(1681-1683)Ctg>Ttg	p.L561L	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	561					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						GCCAGGAACAGTGCCCGCCGT	0.562000													25	44					0	0	0.750413	0	0
AHDC1	27245	broad.mit.edu	37	1	27875714	27875714	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:27875714G>A	ENST00000374011.2	-	6	3881	c.2913C>T	c.(2911-2913)taC>taT	p.Y971Y	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Silent_p.Y971Y	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	971							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CATAGCCGCCGTACTGGGGCA	0.657000													37	26					0	0	0.870114	0	0
RHOU	58480	broad.mit.edu	37	1	228879349	228879349	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:228879349G>T	ENST00000366691.3	+	3	1305	c.639G>T	c.(637-639)gaG>gaT	p.E213D		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	213					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				ACCTCAAAGAGGTCTTTGATG	0.483000													52	137					2.69774e-35	3.00544e-35	0.870114	1	0
SYNE1	23345	broad.mit.edu	37	6	152542150	152542150	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:152542150G>A	ENST00000367255.5	-	119	22289	c.21688C>T	c.(21688-21690)Cag>Tag	p.Q7230*	SYNE1_ENST00000356820.4_Nonsense_Mutation_p.Q1754*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.Q7230*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.Q6842*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.Q7159*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.Q7159*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7230					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACTGTAGCTGCTCAGCAATC	0.448000										HNSCC(10;0.0054)			46	95					0	0	0.870114	0	0
IYD	389434	broad.mit.edu	37	6	150690236	150690236	+	Silent	SNP	C	C	A	rs138283020	by1000genomes	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:150690236C>A	ENST00000344419.3	+	1	209	c.69C>A	c.(67-69)gcC>gcA	p.A23A	IYD_ENST00000392256.2_Silent_p.A23A|IYD_ENST00000392255.3_Silent_p.A23A|IYD_ENST00000229447.5_Silent_p.A23A|IYD_ENST00000500320.3_Silent_p.A23A	NM_203395.2	NP_981932.1	Q6PHW0	IYD1_HUMAN	iodotyrosine deiodinase	23					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	15		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TTAAAAATGCCGACAGAAGCA	0.512000													157	274					1.565e-67	1.76932e-67	0.870114	1	0
ECEL1	9427	broad.mit.edu	37	2	233347836	233347836	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:233347836A>G	ENST00000304546.1	-	9	1770	c.1560T>C	c.(1558-1560)gaT>gaC	p.D520D	ECEL1_ENST00000409941.1_Silent_p.D520D	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	520					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGTCCACAGCATCGGGTTTCA	0.647000													5	11					0	0	0.217242	0	0
MUC17	140453	broad.mit.edu	37	7	100679747	100679747	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:100679747A>G	ENST00000306151.4	+	3	5114	c.5050A>G	c.(5050-5052)Act>Gct	p.T1684A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1684	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCAACCTCAACTTATACTGA	0.463000													165	307					0	0	0.870114	0	0
MARS	4141	broad.mit.edu	37	12	57894296	57894296	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:57894296C>T	ENST00000262027.5	+	10	1418	c.1284C>T	c.(1282-1284)gtC>gtT	p.V428V	MARS_ENST00000315473.5_Silent_p.V194V|MARS_ENST00000447721.2_3'UTR	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	428					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TCAATGCTGTCGAGCTTAAGG	0.537000													11	48					0	0	0.361761	0	0
ERMP1	79956	broad.mit.edu	37	9	5811273	5811273	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:5811273C>T	ENST00000339450.5	-	7	1254	c.1165G>A	c.(1165-1167)Gct>Act	p.A389T	ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_Missense_Mutation_p.A165T	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	389					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		GAAGCAGCAGCCAGCATATCA	0.368000													57	54					0	0	0.870114	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85521681	85521681	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:85521681G>T	ENST00000393217.2	+	18	4140	c.4079G>T	c.(4078-4080)aGg>aTg	p.R1360M		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1360	IQ 2.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TTCTCCACAAGGCTACATACT	0.398000													94	201					5.71645e-57	6.43675e-57	0.870114	1	0
C19orf35	374872	broad.mit.edu	37	19	2275750	2275750	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:2275750G>A	ENST00000342063.3	-	4	1444	c.1351C>T	c.(1351-1353)Ctg>Ttg	p.L451L		NM_198532.2	NP_940934.1	Q6ZS72	CS035_HUMAN	chromosome 19 open reading frame 35	451										large_intestine(1)|lung(5)|pancreas(1)|prostate(1)	8				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCAACACAGCCAGTCCTCG	0.721000													4	0					0	0	0.184627	0	0
TRIM48	79097	broad.mit.edu	37	11	55032522	55032522	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:55032522T>C	ENST00000417545.2	+	2	277	c.191T>C	c.(190-192)aTt>aCt	p.I64T		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	48						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GACATCCCAATTCTTACTCAG	0.458000													73	143					0	0	0.870114	0	0
APAF1	317	broad.mit.edu	37	12	99100325	99100325	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:99100325T>C	ENST00000357310.1	+	18	3106	c.2529T>C	c.(2527-2529)caT>caC	p.H843H	APAF1_ENST00000550527.1_Silent_p.H875H|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000547045.1_Silent_p.H843H|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000549007.1_Silent_p.H843H|APAF1_ENST00000359972.2_Silent_p.H832H|APAF1_ENST00000339433.3_Silent_p.H843H|APAF1_ENST00000551964.1_Silent_p.H886H	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	886					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	GTTGGGTTCATGGTGTGATGT	0.373000													92	170					0	0	0.870114	0	0
ATP6AP1	537	broad.mit.edu	37	X	153662708	153662708	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:153662708A>G	ENST00000369762.2	+	7	900	c.839A>G	c.(838-840)gAc>gGc	p.D280G		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	280					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGTACAAGGACCAGTGGGAG	0.557000													81	51					0	0	0.870114	0	0
TULP2	7288	broad.mit.edu	37	19	49385360	49385360	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:49385360T>C	ENST00000221399.3	-	12	1520	c.1376A>G	c.(1375-1377)tAc>tGc	p.Y459C		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	459					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ATTGAGCGTGTAGACACCGTT	0.527000													5	185					0	0	0.184627	0	0
ZNF408	79797	broad.mit.edu	37	11	46726767	46726767	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:46726767G>A	ENST00000311764.2	+	5	1747	c.1517G>A	c.(1516-1518)cGt>cAt	p.R506H		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGGGCGTTTCGTCAGCGGGGC	0.657000													40	111					0	0	0.870114	0	0
ACSL4	2182	broad.mit.edu	37	X	108912280	108912280	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:108912280A>G	ENST00000340800.2	-	11	1752	c.1248T>C	c.(1246-1248)gaT>gaC	p.D416D	ACSL4_ENST00000348502.6_Silent_p.D375D|ACSL4_ENST00000469796.2_Silent_p.D416D	NM_022977.2	NP_075266.1	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	416					fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)	22					Icosapent(DB00159)|Troglitazone(DB00197)	AAAGAGGTGCATCATATCCCT	0.323000													76	58					0	0	0.870114	0	0
STRN3	29966	broad.mit.edu	37	14	31420083	31420083	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:31420083T>A	ENST00000355683.5	-	4	743	c.528A>T	c.(526-528)agA>agT	p.R176S	STRN3_ENST00000357479.5_Missense_Mutation_p.R176S	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3	176	Calmodulin-binding (Potential).				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTAAAAGCTGTCTGCCTTGCT	0.338000													52	137					0	0	0.870114	0	0
MPV17	4358	broad.mit.edu	37	2	27535925	27535925	+	Missense_Mutation	SNP	C	C	A	rs140992482		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:27535925C>A	ENST00000380044.1	-	3	177	c.122G>T	c.(121-123)cGg>cTg	p.R41L	MPV17_ENST00000233545.2_Missense_Mutation_p.R41L|MPV17_ENST00000402722.1_Silent_p.A29A|MPV17_ENST00000402310.1_Missense_Mutation_p.R41L|MPV17_ENST00000403262.2_Missense_Mutation_p.R41L|MPV17_ENST00000405983.1_Missense_Mutation_p.R56L|MPV17_ENST00000357186.6_Intron|MPV17_ENST00000405076.1_Missense_Mutation_p.R41L	NM_002437.4	NP_002428.1	P39210	MPV17_HUMAN	MpV17 mitochondrial inner membrane protein	41					cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane		p.R56L(1)|p.R41L(1)		lung(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGCAGACCCCGCCTCTCCAC	0.592000													29	64					2.64894e-19	2.88975e-19	0.870114	1	0
RB1	5925	broad.mit.edu	37	13	49051536	49051536	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:49051536A>G	ENST00000267163.4	+	26	2847	c.2709A>G	c.(2707-2709)gaA>gaG	p.E903E	RB1_ENST00000484879.1_3'UTR	NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	903	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AACTGGCAGAAATGAGTAAGT	0.299000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			22	32					0	0	0.681144	0	0
ATXN1	6310	broad.mit.edu	37	6	16328183	16328183	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:16328183T>C	ENST00000244769.4	-	8	1295	c.359A>G	c.(358-360)tAc>tGc	p.Y120C	ATXN1_ENST00000436367.1_Missense_Mutation_p.Y120C	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	120					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CAGGTGAGCGTACTGCACGGG	0.662000													33	64					0	0	0.750413	0	0
SMOX	54498	broad.mit.edu	37	20	4163091	4163091	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:4163091T>C	ENST00000305958.4	+	5	1190	c.965T>C	c.(964-966)cTg>cCg	p.L322P	SMOX_ENST00000278795.3_Intron|SMOX_ENST00000339123.6_Intron|SMOX_ENST00000346595.2_Intron|SMOX_ENST00000379460.2_Missense_Mutation_p.L322P	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	322					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	GACTGTGAGCTGATCCCGGCG	0.637000													23	62					0	0	0.667858	0	0
LRIT3	345193	broad.mit.edu	37	4	110791607	110791607	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:110791607A>G	ENST00000327908.3	+	4	1917	c.1153A>G	c.(1153-1155)Acc>Gcc	p.T385A	LRIT3_ENST00000594814.1_Missense_Mutation_p.T568A|LRIT3_ENST00000409621.2_Missense_Mutation_p.T385A|LRIT3_ENST00000379920.3_Missense_Mutation_p.T523A			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	523	Ser-rich.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		CCAATGCATCACCTTTTCTAC	0.463000													4	98					0	0	0.150653	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42408499	42408499	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:42408499C>T	ENST00000599846.1	+	23	2418	c.2293C>T	c.(2293-2295)Cgg>Tgg	p.R765W	ARHGEF1_ENST00000347545.4_Missense_Mutation_p.R676W|ARHGEF1_ENST00000337665.4_Missense_Mutation_p.R724W|ARHGEF1_ENST00000378152.4_Missense_Mutation_p.R691W|ARHGEF1_ENST00000354532.3_Missense_Mutation_p.R709W			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	709					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GCCCGTGCTGCGGCTCACCTC	0.677000													4	5					0	0	0.150653	0	0
CHD4	1108	broad.mit.edu	37	12	6710842	6710842	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:6710842T>C	ENST00000309577.6	-	5	692	c.529A>G	c.(529-531)Aac>Gac	p.N177D	CHD4_ENST00000357008.2_Missense_Mutation_p.N177D|CHD4_ENST00000544484.1_Missense_Mutation_p.N174D|CHD4_ENST00000544040.1_Missense_Mutation_p.N170D			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	177					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCTTGTAGTTGGTGAGGGTT	0.478000													246	437					0	0	0.870114	0	0
HTR5A	3361	broad.mit.edu	37	7	154863209	154863209	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:154863209C>T	ENST00000287907.2	+	1	1176	c.600C>T	c.(598-600)taC>taT	p.Y200Y	AC093726.4_ENST00000543018.1_5'UTR|AC093726.4_ENST00000493904.1_5'UTR|AC093726.4_ENST00000395731.2_5'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	200						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		AGCCTTCCTACGCCGTGTTCT	0.612000													12	32					0	0	0.479597	0	0
AHCTF1	25909	broad.mit.edu	37	1	247024444	247024444	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:247024444T>C	ENST00000366508.1	-	29	4130	c.3994A>G	c.(3994-3996)Agt>Ggt	p.S1332G	AHCTF1_ENST00000326225.3_Missense_Mutation_p.S1306G|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Missense_Mutation_p.S1297G			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1297	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCTCTAAACTTTGTGACCCC	0.453000													62	95					0	0	0.870114	0	0
KCNN2	3781	broad.mit.edu	37	5	113822745	113822745	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:113822745A>G	ENST00000512097.3	+	7	2272		c.e7-1		KCNN2_ENST00000264773.3_Splice_Site|KCNN2_ENST00000507750.1_Splice_Site|KCNN2_ENST00000503706.1_Splice_Site			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2							integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTCTCTTAACAGGTAAAAAAT	0.373000													41	83					0	0	0.847076	0	0
ZNF771	51333	broad.mit.edu	37	16	30419389	30419389	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:30419389G>A	ENST00000319296.5	+	2	392	c.15G>A	c.(13-15)caG>caA	p.Q5Q	ZNF771_ENST00000564550.1_Silent_p.Q5Q|ZNF771_ENST00000566625.1_Silent_p.Q5Q|ZNF771_ENST00000434417.1_Silent_p.Q5Q			Q7L3S4	ZN771_HUMAN	zinc finger protein 771	5	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding							Colorectal(24;0.193)			CTGGCGAACagcaggcagagg	0.652000													10	15					0	0	0.387290	0	0
ALS2	57679	broad.mit.edu	37	2	202591542	202591542	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:202591542T>C	ENST00000264276.6	-	18	3399	c.3027A>G	c.(3025-3027)agA>agG	p.R1009R	ALS2_ENST00000457679.2_Silent_p.R321R	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	1009					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CAGACATCCCTCTCAAAGCCT	0.448000													6	76					0	0	0.248553	0	0
PLAT	5327	broad.mit.edu	37	8	42040264	42040264	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:42040264A>G	ENST00000220809.4	-	8	1032	c.776T>C	c.(775-777)cTg>cCg	p.L259P	PLAT_ENST00000519510.1_Missense_Mutation_p.L196P|PLAT_ENST00000429089.2_Missense_Mutation_p.L259P|PLAT_ENST00000429710.2_Missense_Mutation_p.L133P|PLAT_ENST00000524009.1_Missense_Mutation_p.L170P|PLAT_ENST00000352041.3_Missense_Mutation_p.L213P|PLAT_ENST00000270189.6_Missense_Mutation_p.L259P	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	259	Kringle 2.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCCCAGGCCCAGTGCCTGGGC	0.592000													101	192					0	0	0.870114	0	0
TMEM68	137695	broad.mit.edu	37	8	56675151	56675151	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:56675151C>T	ENST00000521229.1	-	3	580	c.368G>A	c.(367-369)tGc>tAc	p.C123Y	TMEM68_ENST00000519784.1_Intron|TMEM68_ENST00000334667.2_Intron|TMEM68_ENST00000434581.2_Intron|TMEM68_ENST00000523073.1_Intron|TMEM68_ENST00000522576.1_Missense_Mutation_p.C123Y			Q96MH6	TMM68_HUMAN	transmembrane protein 68	0						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			TCCAATGCAGCACACATGAAT	0.403000													65	112					0	0	0.870114	0	0
MTUS2	23281	broad.mit.edu	37	13	29600226	29600226	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:29600226A>G	ENST00000431530.3	+	1	1479	c.1421A>G	c.(1420-1422)aAg>aGg	p.K474R		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	464						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AGTGGGAATAAGGACAGTGTT	0.512000													22	57					0	0	0.608945	0	0
TRGV4	6977	broad.mit.edu	37	7	38393527	38393527	+	RNA	SNP	G	G	T	rs111340760		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:38393527G>T	ENST00000390345.2	-	0	476																											GATGTAGCCGGTACTTCCTTC	0.512000													11	95					3.27435e-08	3.41672e-08	0.457914	1	0
STOML1	9399	broad.mit.edu	37	15	74281026	74281026	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:74281026C>A	ENST00000316900.5	-	4	632	c.508G>T	c.(508-510)Gcc>Tcc	p.A170S	STOML1_ENST00000316911.6_Missense_Mutation_p.A120S|STOML1_ENST00000541638.1_Missense_Mutation_p.A128S|STOML1_ENST00000359750.4_Missense_Mutation_p.A170S|STOML1_ENST00000561656.1_Missense_Mutation_p.A83S|STOML1_ENST00000564777.1_Missense_Mutation_p.A120S	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	170						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						GCGTTCTGGGCTGTCATGCGT	0.607000													47	87					2.48254e-18	2.69075e-18	0.870114	1	0
HHIPL1	84439	broad.mit.edu	37	14	100129284	100129284	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:100129284G>A	ENST00000330710.5	+	6	1672	c.1574G>A	c.(1573-1575)gGc>gAc	p.G525D	HHIPL1_ENST00000357223.2_Missense_Mutation_p.G525D	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	525					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				ATGGGCCACGGCCAGACCTGT	0.582000													32	61					0	0	0.812448	0	0
DSG3	1830	broad.mit.edu	37	18	29046491	29046491	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:29046491A>G	ENST00000257189.4	+	11	1494		c.e11-1			NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3						cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTGTTCTTACAGAATACACGG	0.358000													80	147					0	0	0.870114	0	0
VPS18	57617	broad.mit.edu	37	15	41192359	41192359	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:41192359T>C	ENST00000220509.5	+	4	1682	c.1343T>C	c.(1342-1344)cTg>cCg	p.L448P	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	448					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TGCTATGCCCTGACCCAGAGC	0.622000													44	108					0	0	0.870114	0	0
NOP14	8602	broad.mit.edu	37	4	2955332	2955332	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:2955332G>A	ENST00000416614.2	-	5	718	c.653C>T	c.(652-654)aCg>aTg	p.T218M	NOP14_ENST00000314262.6_Missense_Mutation_p.T218M|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000398071.4_Missense_Mutation_p.T218M|NOP14_ENST00000502735.1_Missense_Mutation_p.T218M			P78316	NOP14_HUMAN	NOP14 nucleolar protein	218					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						TAGCTTCTCCGTGAGCTCGAG	0.483000													203	185					0	0	0.870114	0	0
ACLY	47	broad.mit.edu	37	17	40049293	40049293	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:40049293G>T	ENST00000352035.2	-	15	1724	c.1594C>A	c.(1594-1596)Cct>Act	p.P532T	ACLY_ENST00000393896.2_Missense_Mutation_p.P522T|ACLY_ENST00000537919.1_Missense_Mutation_p.P261T|ACLY_ENST00000353196.1_Missense_Mutation_p.P522T|ACLY_ENST00000590151.1_Missense_Mutation_p.P532T	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	532					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CACGTGAAAGGGTAGACCATG	0.577000													4	58					0.150653	0.151556	0.150653	1	0
WWP2	11060	broad.mit.edu	37	16	69832614	69832614	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:69832614C>T	ENST00000359154.2	+	3	201	c.100C>T	c.(100-102)Cgt>Tgt	p.R34C	WWP2_ENST00000569174.1_Missense_Mutation_p.R34C|WWP2_ENST00000356003.2_Missense_Mutation_p.R34C|WWP2_ENST00000448661.1_Missense_Mutation_p.R34C	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	34	C2.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGTGCATAATCGTCAACCTCG	0.542000											OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	139					0	0	0.870114	0	0
VSTM2L	128434	broad.mit.edu	37	20	36572445	36572445	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:36572445G>A	ENST00000373459.4	+	2	424	c.184G>A	c.(184-186)Gga>Aga	p.G62R	VSTM2L_ENST00000373461.4_Silent_p.T135T|VSTM2L_ENST00000373458.3_Silent_p.T118T			Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	0	Ig-like.									central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.00878)				TGAAGCCCACGGACGAAGGCA	0.642000													9	20					0	0	0.361761	0	0
BET1L	51272	broad.mit.edu	37	11	205968	205968	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:205968A>G	ENST00000325147.9	-	2	155	c.95T>C	c.(94-96)gTc>gCc	p.V32A	BET1L_ENST00000382762.3_Missense_Mutation_p.V32A|BET1L_ENST00000332865.6_Missense_Mutation_p.V32A|BET1L_ENST00000486280.1_Missense_Mutation_p.V9A|BET1L_ENST00000410108.1_Missense_Mutation_p.V32A|BET1L_ENST00000529614.2_Missense_Mutation_p.V32A			Q9NYM9	BET1L_HUMAN	Bet1 golgi vesicular membrane trafficking protein-like	32	t-SNARE coiled-coil homology.				protein transport|retrograde transport, endosome to Golgi	endosome|SNARE complex	SNAP receptor activity						all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;4.2e-27)|Epithelial(43;2.8e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.7e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAGCCTGGTGACTTTGGAGGC	0.587000													30	79					0	0	0.796494	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150532263	150532263	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:150532263G>A	ENST00000271643.4	+	18	3206	c.2970G>A	c.(2968-2970)acG>acA	p.T990T	ADAMTSL4_ENST00000369039.5_Silent_p.T1013T|ADAMTSL4_ENST00000369038.2_Silent_p.T990T	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	990	TSP type-1 6.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAGGGGGAACGCAGACACGGG	0.637000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	110					0	0	0.624587	0	0
BRINP3	339479	broad.mit.edu	37	1	190203594	190203594	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:190203594C>T	ENST00000367462.3	-	5	863	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.R109Q	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		211						extracellular region		p.R211Q(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGGACCAGTCCGTGTTTCTGT	0.383000													66	109					0	0	0.870114	0	0
PDLIM1	9124	broad.mit.edu	37	10	96998377	96998377	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:96998377T>A	ENST00000329399.6	-	6	859	c.751A>T	c.(751-753)Att>Ttt	p.I251F	PDLIM1_ENST00000477757.1_5'UTR	NM_020992.2	NP_066272.1	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	251					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding			endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|skin(2)	10		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GCATTTCCAATCGACGCAGCC	0.493000													18	41					0	0	0.608945	0	0
DENND4B	9909	broad.mit.edu	37	1	153904719	153904719	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:153904719G>A	ENST00000361217.4	-	24	4375	c.3957C>T	c.(3955-3957)ggC>ggT	p.G1319G	DENND4B_ENST00000474386.1_5'UTR	NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1319										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCAGCACCAGGCCTGGTAGAA	0.587000													8	14					0	0	0.307466	0	0
KIRREL	55243	broad.mit.edu	37	1	158064480	158064480	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:158064480C>A	ENST00000368172.1	+	11	1298	c.1286C>A	c.(1285-1287)cCg>cAg	p.P429Q	KIRREL_ENST00000360089.4_Missense_Mutation_p.P451Q|KIRREL_ENST00000368173.3_Missense_Mutation_p.P631Q|KIRREL_ENST00000392272.2_Missense_Mutation_p.P512Q|KIRREL_ENST00000359209.6_Missense_Mutation_p.P615Q|KIRREL_ENST00000416935.2_Missense_Mutation_p.P515Q			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	615	Ig-like C2-type 5.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					GAAGACCGCCCGTCTTCCAGG	0.642000													13	32					3.32936e-07	3.46122e-07	0.539581	1	0
GPR133	283383	broad.mit.edu	37	12	131466593	131466593	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:131466593T>C	ENST00000261654.5	+	5	1034	c.475T>C	c.(475-477)Tcc>Ccc	p.S159P	GPR133_ENST00000535015.1_Missense_Mutation_p.S191P	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	159					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ATGGGAGGCCTCCTTCAGCCC	0.602000													29	72					0	0	0.760397	0	0
KRT4	3851	broad.mit.edu	37	12	53202484	53202484	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:53202484G>T	ENST00000293774.4	-	5	1477	c.1207C>A	c.(1207-1209)Ctg>Atg	p.L403M	KRT4_ENST00000551956.1_Missense_Mutation_p.L329M|KRT4_ENST00000458244.2_Missense_Mutation_p.L309M			B4DRS2	B4DRS2_HUMAN	keratin 4	329						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GTCTGGTACAGGGCTTCAGCC	0.562000													19	56					3.7963e-18	4.1094e-18	0.654019	1	0
OTOGL	283310	broad.mit.edu	37	12	80660299	80660299	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:80660299C>A	ENST00000458043.2	+	20	2272	c.2266C>A	c.(2266-2268)Ctc>Atc	p.L756I	OTOGL_ENST00000547103.1_Missense_Mutation_p.L756I	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTGCATTTCTCTCTCTTCCCC	0.468000													26	58					3.28513e-13	3.49747e-13	0.667858	1	0
PRPS1L1	221823	broad.mit.edu	37	7	18066798	18066798	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:18066798T>C	ENST00000506618.2	-	1	688	c.608A>G	c.(607-609)gAc>gGc	p.D203G		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	203					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					CACTATGCAGTCCACTTCATT	0.463000													64	114					0	0	0.870114	0	0
ITIH2	3698	broad.mit.edu	37	10	7791150	7791150	+	Splice_Site	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:7791150G>A	ENST00000358415.4	+	21	2860	c.2693_splice	c.e21-1	p.R898_splice	ITIH2_ENST00000379587.4_Splice_Site_p.R887_splice	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	898					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TTCCTTGCAGGGGCTTACAGA	0.493000													110	204					0	0	0.870114	0	0
RBM19	9904	broad.mit.edu	37	12	114395588	114395588	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:114395588T>C	ENST00000545145.2	-	6	917	c.840_splice	c.e6+1	p.E280_splice	RBM19_ENST00000392561.3_Splice_Site_p.E280_splice|RBM19_ENST00000261741.5_Splice_Site_p.E280_splice	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	280					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CACACGCACCTCGGCTCTGGC	0.622000													49	115					0	0	0.870114	0	0
ZNF57	126295	broad.mit.edu	37	19	2918270	2918270	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:2918270A>G	ENST00000306908.5	+	4	1799	c.1651A>G	c.(1651-1653)Agt>Ggt	p.S551G	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Missense_Mutation_p.S519G	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTAAAACCAGTGAGAGCAC	0.408000													59	49					0	0	0.870114	0	0
BRD9	65980	broad.mit.edu	37	5	884146	884146	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:884146C>T	ENST00000323510.4	-	5	584	c.585G>A	c.(583-585)acG>acA	p.T195T	BRD9_ENST00000494422.1_Intron|BRD9_ENST00000435709.2_Silent_p.T175T|BRD9_ENST00000483173.1_Silent_p.T238T|BRD9_ENST00000467963.1_Silent_p.T291T|BRD9_ENST00000388890.4_Silent_p.T175T			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	291	Bromo.						nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			CGGTACTGTCCGTCAAGCTGC	0.637000													32	69					0	0	0.812448	0	0
FZD10	11211	broad.mit.edu	37	12	130647929	130647929	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:130647929A>G	ENST00000539839.1	+	1	926	c.344A>G	c.(343-345)cAt>cGt	p.H115R	FZD10_ENST00000229030.4_Missense_Mutation_p.M148V	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CTACCTGTGCATGGAGGCGCC	0.667000													41	64					0	0	0.870114	0	0
MYH10	4628	broad.mit.edu	37	17	8409751	8409751	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:8409751G>C	ENST00000360416.3	-	27	3409	c.3271C>G	c.(3271-3273)Ctc>Gtc	p.L1091V	MYH10_ENST00000269243.4_Missense_Mutation_p.L1060V|MYH10_ENST00000396239.1_Missense_Mutation_p.L1081V|MYH10_ENST00000379980.4_Missense_Mutation_p.L1076V	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1060					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCCCCGTCGAGTTTTCTTTTG	0.512000													84	154					0	0	0.870114	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762925	140762925	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140762925G>A	ENST00000518325.1	+	1	459	c.459G>A	c.(457-459)ccG>ccA	p.P153P	PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGGTTTCCGTTAAGCGAGG	0.478000													4	94					0	0	0.150653	0	0
MCRS1	10445	broad.mit.edu	37	12	49953240	49953240	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:49953240C>T	ENST00000550165.1	-	13	1348	c.1082G>A	c.(1081-1083)cGt>cAt	p.R361H	MCRS1_ENST00000547182.1_5'UTR|MCRS1_ENST00000546244.1_Missense_Mutation_p.R170H|MCRS1_ENST00000357123.4_Missense_Mutation_p.R374H|MCRS1_ENST00000343810.4_Missense_Mutation_p.R361H			Q96EZ8	MCRS1_HUMAN	microspherule protein 1	361					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)	23						CCTCACCTCACGCGAGCGCAT	0.602000													20	44					0	0	0.624587	0	0
COL6A2	1292	broad.mit.edu	37	21	47532364	47532364	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:47532364T>C	ENST00000300527.4	+	3	691	c.587T>C	c.(586-588)cTg>cCg	p.L196P	COL6A2_ENST00000409416.1_Missense_Mutation_p.L196P|COL6A2_ENST00000357838.4_Missense_Mutation_p.L196P|COL6A2_ENST00000460886.1_3'UTR|COL6A2_ENST00000397763.1_Missense_Mutation_p.L196P|COL6A2_ENST00000310645.5_Missense_Mutation_p.L196P	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	196	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AACCAGAACCTGAAGGAGCAG	0.706000													16	20					0	0	0.479597	0	0
ERAP2	64167	broad.mit.edu	37	5	96251400	96251400	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:96251400T>C	ENST00000437043.3	+	18	3377	c.2666T>C	c.(2665-2667)tTg>tCg	p.L889S	CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Missense_Mutation_p.L844S	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	889					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		AGATTTGACTTGGGCTCATAT	0.294000													49	272					0	0	0.870114	0	0
MARK1	4139	broad.mit.edu	37	1	220808856	220808856	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:220808856C>T	ENST00000402574.1	+	12	1858	c.856C>T	c.(856-858)Cgt>Tgt	p.R286C	MARK1_ENST00000366918.4_Missense_Mutation_p.R399C|MARK1_ENST00000366917.4_Missense_Mutation_p.R421C	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	421	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		GAAGCAGCGGCGTTTCAGTGA	0.463000													34	72					0	0	0.788014	0	0
SIL1	64374	broad.mit.edu	37	5	138456826	138456826	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:138456826T>C	ENST00000394817.2	-	3	281	c.142A>G	c.(142-144)Acc>Gcc	p.T48A	SIL1_ENST00000509534.1_Missense_Mutation_p.T55A|SIL1_ENST00000265195.5_Missense_Mutation_p.T48A	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	48	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTTTCTTTGGTGCTGCTCTTC	0.527000									Marinesco-Sjgren syndrome				69	141					0	0	0.870114	0	0
IQCK	124152	broad.mit.edu	37	16	19800174	19800174	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:19800174T>A	ENST00000320394.6	+	8	1319	c.620T>A	c.(619-621)aTc>aAc	p.I207N	IQCK_ENST00000541926.1_Intron|IQCK_ENST00000433597.2_Missense_Mutation_p.I119N|IQCK_ENST00000564186.1_Missense_Mutation_p.I207N|IQCK_ENST00000562762.1_3'UTR	NM_153208.1	NP_694940.1	Q8N0W5	IQCK_HUMAN	IQ motif containing K	207										kidney(1)|large_intestine(2)|lung(2)|skin(1)	6						CGGCCGCCAATCCCACTCTCG	0.483000													13	139					0	0	0.479597	0	0
ACSL1	2180	broad.mit.edu	37	4	185697722	185697722	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:185697722T>C	ENST00000515030.1	-	7	997	c.672A>G	c.(670-672)atA>atG	p.I224M	ACSL1_ENST00000454703.2_Missense_Mutation_p.I53M|ACSL1_ENST00000437665.3_Missense_Mutation_p.I53M|ACSL1_ENST00000507295.1_Missense_Mutation_p.I190M|ACSL1_ENST00000504342.1_Missense_Mutation_p.I224M|ACSL1_ENST00000513317.1_Missense_Mutation_p.I224M|ACSL1_ENST00000281455.2_Missense_Mutation_p.I224M|ACSL1_ENST00000504900.1_Missense_Mutation_p.I224M			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	224					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCATGACAACTATGATTTTAA	0.488000													56	43					0	0	0.870114	0	0
ZNF777	27153	broad.mit.edu	37	7	149129497	149129497	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:149129497C>T	ENST00000247930.4	-	6	2189	c.1866G>A	c.(1864-1866)aaG>aaA	p.K622K		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	622					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			AGCTGGGTGACTTGGGACGCG	0.667000													43	72					0	0	0.870114	0	0
COG2	22796	broad.mit.edu	37	1	230805234	230805234	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:230805234G>A	ENST00000534989.1	+	7	885	c.550G>A	c.(550-552)Gcg>Acg	p.A184T	COG2_ENST00000494371.1_3'UTR|COG2_ENST00000366668.3_Missense_Mutation_p.A243T|COG2_ENST00000366669.4_Missense_Mutation_p.A243T|COG2_ENST00000535166.1_Missense_Mutation_p.A127T			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	243					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GACACGGGACGCGGAGGCCTT	0.488000													39	77					0	0	0.847076	0	0
MRPS22	56945	broad.mit.edu	37	3	139062900	139062900	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:139062900G>A	ENST00000495075.1	+	3	464	c.32G>A	c.(31-33)tGg>tAg	p.W11*	MRPS22_ENST00000465056.1_Nonsense_Mutation_p.W11*|MRPS22_ENST00000310776.4_Nonsense_Mutation_p.W11*			P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	11						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12						GTATTGCTGTGGAGCCTCTTG	0.592000													23	39					0	0	0.693898	0	0
RNASEL	6041	broad.mit.edu	37	1	182550456	182550456	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:182550456G>A	ENST00000367559.3	-	5	2062	c.1809C>T	c.(1807-1809)tcC>tcT	p.S603S	RNASEL_ENST00000539397.1_Silent_p.S603S|RNASEL_ENST00000444138.1_Silent_p.S603S	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	603	KEN.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						TTTTGATGTCGGATTCATTTC	0.428000													6	340					0	0	0.248553	0	0
MYOM2	9172	broad.mit.edu	37	8	2077161	2077161	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:2077161A>G	ENST00000262113.4	+	32	3882	c.3741A>G	c.(3739-3741)atA>atG	p.I1247M	MYOM2_ENST00000523438.1_Missense_Mutation_p.I672M	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1247					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CAGAAGGAATACGACTTCAGT	0.448000													40	96					0	0	0.870114	0	0
MADD	8567	broad.mit.edu	37	11	47305943	47305943	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:47305943C>G	ENST00000342922.4	+	12	2341	c.1984C>G	c.(1984-1986)Cat>Gat	p.H662D	MADD_ENST00000406482.1_Missense_Mutation_p.H662D|MADD_ENST00000395344.3_Missense_Mutation_p.H662D|MADD_ENST00000402799.1_Missense_Mutation_p.H662D|MADD_ENST00000402192.2_Missense_Mutation_p.H662D|MADD_ENST00000311027.5_Missense_Mutation_p.H662D|MADD_ENST00000349238.3_Missense_Mutation_p.H662D|MADD_ENST00000395336.3_Missense_Mutation_p.H662D|MADD_ENST00000407859.3_Missense_Mutation_p.H662D	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	662					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CCCTCTGACACATGCAGCACT	0.582000													36	54					0	0	0.819951	0	0
PSPH	5723	broad.mit.edu	37	7	56085002	56085002	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:56085002C>T	ENST00000395471.3	-	6	1151	c.346G>A	c.(346-348)Gta>Ata	p.V116I	PSPH_ENST00000275605.3_Missense_Mutation_p.V116I|PSPH_ENST00000459834.1_Intron			P78330	SERB_HUMAN	phosphoserine phosphatase	116					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity	p.V116I(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACATGCTCTACAATACTCCTA	0.393000													4	127					0	0	0.150653	0	0
NAV1	89796	broad.mit.edu	37	1	201779752	201779752	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:201779752G>A	ENST00000367296.4	+	24	5083	c.4663G>A	c.(4663-4665)Gtc>Atc	p.V1555I	NAV1_ENST00000295624.6_Missense_Mutation_p.V1552I|NAV1_ENST00000367295.1_Missense_Mutation_p.V1161I|NAV1_ENST00000367300.3_Missense_Mutation_p.V1495I|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367297.4_Missense_Mutation_p.V1547I|NAV1_ENST00000367302.1_Missense_Mutation_p.V1508I	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1555					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CCGGCGCCTCGTCCTCTCGGG	0.622000													4	36					0	0	0.150653	0	0
TRIT1	54802	broad.mit.edu	37	1	40307451	40307451	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:40307451C>A	ENST00000316891.5	-	11	1383	c.1369G>T	c.(1369-1371)Ggg>Tgg	p.G457W	TRIT1_ENST00000491865.1_5'UTR|TRIT1_ENST00000441669.2_Missense_Mutation_p.G375W|TRIT1_ENST00000537440.1_Missense_Mutation_p.G153W|TRIT1_ENST00000372818.1_Missense_Mutation_p.G431W|TRIT1_ENST00000545233.1_Missense_Mutation_p.G211W|TRIT1_ENST00000541099.1_Missense_Mutation_p.G75W|TRIT1_ENST00000537223.1_Missense_Mutation_p.G153W	NM_017646.4	NP_060116.2	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1	457					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			breast(1)|large_intestine(5)|liver(1)|lung(3)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(1)	15	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCATTCTGCCCTGGGGATCCC	0.473000													8	367					0.0381472	0.038514	0.278610	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74754945	74754945	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:74754945C>T	ENST00000380494.5	-	4	970	c.677G>A	c.(676-678)cGt>cAt	p.R226H	COL4A3BP_ENST00000405807.4_Missense_Mutation_p.R98H|COL4A3BP_ENST00000261415.7_Missense_Mutation_p.R98H	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	98					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		ATCCTGAGCACGAAGATACCA	0.388000													65	109					0	0	0.870114	0	0
ZMYND12	84217	broad.mit.edu	37	1	42914182	42914182	+	Missense_Mutation	SNP	A	A	G	rs144825054		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:42914182A>G	ENST00000372565.3	-	3	649	c.380T>C	c.(379-381)gTa>gCa	p.V127A	ZMYND12_ENST00000433602.2_Intron	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	127						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CACAAGCTCTACGGAGCTCAG	0.522000													20	21					0	0	0.557998	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	54					0	0	0.184627	0	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859576	31859576	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:31859576C>A	ENST00000334055.3	-	1	179	c.92G>T	c.(91-93)aGa>aTa	p.R31I		NM_181608.1	NP_853639.1	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	31						intermediate filament				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						TCCACAGCCTCTGTGGCCACA	0.512000													39	86					1.15505e-17	1.2471e-17	0.847076	1	0
TTN	7273	broad.mit.edu	37	2	179400235	179400235	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:179400235G>A	ENST00000589042.1	-	358	101331	c.101107C>T	c.(101107-101109)Cga>Tga	p.R33703*	TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.R24763*|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.R31135*|TTN-AS1_ENST00000591466.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.R24638*|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.R32062*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.R24830*|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32062	Ig-like 148.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAATCTCGTGAGACATCA	0.438000													32	73					0	0	0.740014	0	0
RELN	5649	broad.mit.edu	37	7	103126801	103126801	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:103126801C>T	ENST00000428762.1	-	61	9985	c.9826G>A	c.(9826-9828)Gca>Aca	p.A3276T	RELN_ENST00000343529.5_Missense_Mutation_p.A3276T|CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000424685.2_Missense_Mutation_p.A3276T	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3276					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GTGACTCTTGCGGACTCAAAA	0.498000													4	171					0	0	0.184627	0	0
PRSS33	260429	broad.mit.edu	37	16	2834653	2834653	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:2834653T>C	ENST00000293851.5	-	6	994	c.835A>G	c.(835-837)Agc>Ggc	p.S279G	PRSS33_ENST00000570702.1_Missense_Mutation_p.S279G|PRSS33_ENST00000576886.1_3'UTR	NM_152891.2	NP_690851.2	Q8NF86	PRS33_HUMAN	protease, serine, 33	279	Peptidase S1.				proteolysis		serine-type endopeptidase activity			prostate(1)	1						CATTAGAAGCTGACGCGAGCC	0.627000													3	9					0	0	0.115264	0	0
PDIA2	64714	broad.mit.edu	37	16	336667	336667	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:336667G>A	ENST00000219406.6	+	9	1372	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	PDIA2_ENST00000404312.1_Missense_Mutation_p.E449K	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	452	Thioredoxin 2.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CACGGCCAACGAGCTGGATGC	0.612000													21	34					0	0	0.667858	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725001	140725001	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140725001A>T	ENST00000253812.6	+	1	1401	c.1401A>T	c.(1399-1401)agA>agT	p.R467S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACCCCAGAGGAGCCTCCA	0.537000													90	160					0	0	0.870114	0	0
MOB3C	148932	broad.mit.edu	37	1	47078581	47078581	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:47078581C>T	ENST00000371940.1	-	1	3556	c.482G>A	c.(481-483)cGt>cAt	p.R161H	MOB3C_ENST00000319928.3_Missense_Mutation_p.R138H|MOB3C_ENST00000477318.1_5'UTR|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000271139.8_Missense_Mutation_p.R190H			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	138							metal ion binding	p.R190H(1)									CTCACCAACACGCGTGGGAAA	0.577000													12	9					0	0	0.435327	0	0
GPR107	57720	broad.mit.edu	37	9	132897302	132897302	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:132897302A>G	ENST00000372406.1	+	20	2213		c.e20-1		GPR107_ENST00000372410.3_Splice_Site|GPR107_ENST00000347136.6_Splice_Site	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107							integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TTCCTTGTTCAGTGTGACAAC	0.498000													10	10					0	0	0.335167	0	0
BAG6	7917	broad.mit.edu	37	6	31615405	31615405	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:31615405C>T	ENST00000404765.2	-	7	1040	c.751G>A	c.(751-753)Gcg>Acg	p.A251T	BAG6_ENST00000211379.5_Missense_Mutation_p.A251T|BAG6_ENST00000439687.2_Missense_Mutation_p.A251T|BAG6_ENST00000375976.4_Missense_Mutation_p.A251T|BAG6_ENST00000375964.6_Missense_Mutation_p.A257T|BAG6_ENST00000362049.6_Missense_Mutation_p.A251T			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	257	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTTGGGCCCGCTGGGGCTGGG	0.592000													97	134					0	0	0.870114	0	0
ZNF319	57567	broad.mit.edu	37	16	58031166	58031166	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:58031166C>T	ENST00000299237.2	-	2	1626	c.1004G>A	c.(1003-1005)cGc>cAc	p.R335H		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						GCTGTGTGTGCGCTCATGCTG	0.682000													5	23					0	0	0.307466	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20871211	20871211	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:20871211A>G	ENST00000324344.3	-	3	1197	c.912T>C	c.(910-912)acT>acC	p.T304T	ERI2_ENST00000564349.1_Intron|DCUN1D3_ENST00000563934.1_Silent_p.T304T	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	304					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		AGAGCCACTAAGTCTGCTCCT	0.542000													15	25					0	0	0.479597	0	0
ZNF433	163059	broad.mit.edu	37	19	12126007	12126007	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:12126007C>A	ENST00000419886.2	-	5	1861	c.1570G>T	c.(1570-1572)Gag>Tag	p.E524*	ZNF433_ENST00000344980.6_Nonsense_Mutation_p.E559*|CTD-2006C1.2_ENST00000495324.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000406892.2_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						TAAGGTTTCTCTCCAGTGTGA	0.458000													70	142					2.23399e-28	2.46591e-28	0.870114	1	0
TRIP12	9320	broad.mit.edu	37	2	230654396	230654396	+	Silent	SNP	C	C	T	rs146874504	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:230654396C>T	ENST00000283943.5	-	30	4579	c.4401G>A	c.(4399-4401)ccG>ccA	p.P1467P	TRIP12_ENST00000389044.4_Silent_p.P1515P|TRIP12_ENST00000389045.3_Silent_p.P1197P	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1467					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CATCTAATGACGGGTCTTCAA	0.358000													103	181					0	0	0.870114	0	0
C1QTNF5	114902	broad.mit.edu	37	11	119210050	119210050	+	Silent	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:119210050G>C	ENST00000445041.2	-	15	3518	c.723C>G	c.(721-723)gtC>gtG	p.V241V	C1QTNF5_ENST00000525657.1_5'UTR|C1QTNF5_ENST00000528368.1_Silent_p.V241V|MFRP_ENST00000530681.1_3'UTR|MFRP_ENST00000555262.1_3'UTR	NM_001278431.1|NM_015645.3|NM_031433.2	NP_001265360.1|NP_056460.1|NP_113621.1	Q9BY79	MFRP_HUMAN	C1q and tumor necrosis factor related protein 5	0	CUB 1.				embryo development	integral to membrane				endometrium(1)|lung(2)	3		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ACTAAGCAAAGACTGGGGAGC	0.567000													28	54					0	0	0.760397	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42364521	42364521	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:42364521A>T	ENST00000290472.3	-	14	1481	c.1387T>A	c.(1387-1389)Ttg>Atg	p.L463M		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	463	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TTGAGGCTCAAGTAGAGGGGC	0.567000													81	183					0	0	0.870114	0	0
TRGV2	6974	broad.mit.edu	37	7	38402598	38402598	+	RNA	SNP	T	T	C	rs3956758		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:38402598T>C	ENST00000426402.2	-	0	410																											CAACACAACCTTGGAGTTGTA	0.458000													22	123					0	0	0.760397	0	0
RNF217	154214	broad.mit.edu	37	6	125397823	125397823	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:125397823A>G	ENST00000521654.2	+	4	1302	c.1302A>G	c.(1300-1302)gaA>gaG	p.E434E	RNF217_ENST00000275184.6_Silent_p.E78E|RNF217_ENST00000359704.2_Silent_p.E142E|RNF217_ENST00000368414.2_5'UTR|RNF217_ENST00000560949.1_Silent_p.E199E			Q8TC41	RN217_HUMAN	ring finger protein 217	142					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		AGCGAACTGAAGGATGTGACC	0.408000													45	103					0	0	0.870114	0	0
DNAH17	8632	broad.mit.edu	37	17	76430163	76430163	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:76430163C>A	ENST00000389840.5	-	75	12278	c.12154G>T	c.(12154-12156)Gac>Tac	p.D4052Y	DNAH17_ENST00000585328.1_Missense_Mutation_p.D4053Y|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATGGTGAGGTCCCCGTTGTTG	0.597000													5	175					0.014758	0.0149538	0.184627	1	0
RBM42	79171	broad.mit.edu	37	19	36128233	36128233	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:36128233C>T	ENST00000262633.4	+	9	1414	c.1309C>T	c.(1309-1311)Cgc>Tgc	p.R437C	RBM42_ENST00000588161.1_Missense_Mutation_p.R407C|RBM42_ENST00000360475.4_Missense_Mutation_p.R408C|RBM42_ENST00000586618.1_Missense_Mutation_p.R141C|RBM42_ENST00000589871.1_Missense_Mutation_p.R415C|RBM42_ENST00000592202.1_Missense_Mutation_p.R383C|RBM42_ENST00000589559.1_Intron	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	437	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACTACGTGCGCGCCATGCG	0.632000													21	49					0	0	0.667858	0	0
MYH8	4626	broad.mit.edu	37	17	10304593	10304593	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:10304593T>C	ENST00000403437.2	-	24	3201	c.3108_splice	c.e24+1	p.D1036_splice	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1036					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TGTGCTTACATCATCCACTTG	0.383000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				8	324					0	0	0.307466	0	0
TIAM1	7074	broad.mit.edu	37	21	32492816	32492816	+	Missense_Mutation	SNP	C	C	T	rs143032407	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:32492816C>T	ENST00000286827.3	-	29	5117	c.4646G>A	c.(4645-4647)cGc>cAc	p.R1549H	TIAM1_ENST00000541036.1_Missense_Mutation_p.R1489H	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1549					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTGTGCCATGCGGGACGCGTG	0.597000													39	75					0	0	0.847076	0	0
MALAT1	378938	broad.mit.edu	37	11	65272262	65272262	+	RNA	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:65272262C>A	ENST00000534336.1	+	0	7030					NR_002819.2																						TTCTCTCTCCCCTCCCTTGGT	0.418000													29	68					6.00712e-18	6.49419e-18	0.760397	1	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.471_splice	c.e5+1	p.H157_splice	AGAP10_ENST00000452145.2_Splice_Site_p.H132_splice|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000413193.2_Splice_Site_p.H228_splice					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													5	72					0	0	0.248553	0	0
TRPM2	7226	broad.mit.edu	37	21	45795728	45795728	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:45795728G>A	ENST00000397928.1	+	6	1229	c.784G>A	c.(784-786)Gcc>Acc	p.A262T	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.A262T|TRPM2_ENST00000397932.2_Missense_Mutation_p.A262T|TRPM2_ENST00000300481.9_Missense_Mutation_p.A262T	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	262						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CAGCTTCCCCGCCGAGTACAT	0.602000													15	25					0	0	0.457914	0	0
RORC	6097	broad.mit.edu	37	1	151785790	151785790	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151785790G>A	ENST00000356728.6	-	7	1190	c.1036C>T	c.(1036-1038)Cgg>Tgg	p.R346W	RORC_ENST00000318247.6_Missense_Mutation_p.R367W|RORC_ENST00000480719.1_5'UTR|RORC_ENST00000392697.3_Missense_Mutation_p.R421W	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	367	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTGTAGGCCCGGCACATCCTA	0.567000													108	207					0	0	0.870114	0	0
ZNF32	7580	broad.mit.edu	37	10	44139700	44139700	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:44139700T>C	ENST00000395797.1	-	3	808	c.620A>G	c.(619-621)cAc>cGc	p.H207R	ZNF32-AS1_ENST00000453284.1_RNA|ZNF32_ENST00000374433.2_Missense_Mutation_p.H207R|ZNF32-AS3_ENST00000458063.1_RNA	NM_001005368.1	NP_001005368.1	P17041	ZNF32_HUMAN	zinc finger protein 32	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	14		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		GACTCTGATGTGAACAATTAA	0.478000													6	166					0	0	0.217242	0	0
APBB1	322	broad.mit.edu	37	11	6431909	6431909	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:6431909G>A	ENST00000389906.2	-	2	768	c.669C>T	c.(667-669)agC>agT	p.S223S	APBB1_ENST00000533407.1_Intron|APBB1_ENST00000299402.6_Silent_p.S223S|APBB1_ENST00000311051.3_Silent_p.S223S	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	223					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AGGTAGCCCAGCTTGAGTCCT	0.612000													20	50					0	0	0.654019	0	0
HADHA	3030	broad.mit.edu	37	2	26416536	26416536	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:26416536C>T	ENST00000380649.3	-	17	1924	c.1795G>A	c.(1795-1797)Gtg>Atg	p.V599M		NM_000182.4	NP_000173.2	P40939	ECHA_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	599					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(4)|skin(1)	30	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCTTCCGCCACATGTTTCGCT	0.547000													112	188					0	0	0.870114	0	0
CTNNA2	1496	broad.mit.edu	37	2	80097023	80097023	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:80097023A>G	ENST00000466387.1	+	9	1271	c.547A>G	c.(547-549)Atg>Gtg	p.M183V	CTNNA2_ENST00000361291.4_Missense_Mutation_p.M217V|CTNNA2_ENST00000496558.1_Missense_Mutation_p.M183V|CTNNA2_ENST00000541047.1_Missense_Mutation_p.M183V|CTNNA2_ENST00000402739.4_Missense_Mutation_p.M183V|CTNNA2_ENST00000540488.1_Missense_Mutation_p.M183V			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	183					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGGGAAAGAGATGGTGAAACT	0.413000													4	185					0	0	0.150653	0	0
PEMT	10400	broad.mit.edu	37	17	17425656	17425656	+	Silent	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:17425656G>T	ENST00000395781.2	-	3	339	c.258C>A	c.(256-258)ccC>ccA	p.P86P	PEMT_ENST00000395782.1_Silent_p.P49P|PEMT_ENST00000435340.2_Silent_p.P64P|PEMT_ENST00000255389.5_Silent_p.P86P|PEMT_ENST00000395783.1_Silent_p.P49P	NM_001267552.1	NP_001254481.1	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	49					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(2)|prostate(3)	7				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		AGGCCAGGTAGGGGGATCCGA	0.572000													5	28					0.00116845	0.00119258	0.217242	1	0
NRP2	8828	broad.mit.edu	37	2	206562300	206562300	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:206562300G>A	ENST00000360409.3	+	2	897	c.106G>A	c.(106-108)Gat>Aat	p.D36N	NRP2_ENST00000540841.1_Missense_Mutation_p.D36N|NRP2_ENST00000540178.1_Missense_Mutation_p.D36N|NRP2_ENST00000355117.4_Missense_Mutation_p.D36N|NRP2_ENST00000412873.2_Missense_Mutation_p.D36N|NRP2_ENST00000357118.4_Missense_Mutation_p.D36N|NRP2_ENST00000357785.5_Missense_Mutation_p.D36N|NRP2_ENST00000272849.3_Missense_Mutation_p.D36N|NRP2_ENST00000417189.1_Missense_Mutation_p.D36N	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	36	CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GAATTCCAAAGATGCTGGCTA	0.512000													7	688					0	0	0.307466	0	0
UQCC1	55245	broad.mit.edu	37	20	33961989	33961989	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:33961989A>T	ENST00000397554.1	-	5	414	c.404T>A	c.(403-405)cTa>cAa	p.L135Q	UQCC_ENST00000407996.2_Intron|UQCC_ENST00000397556.3_Missense_Mutation_p.L36Q|UQCC_ENST00000374385.5_Missense_Mutation_p.L135Q|UQCC_ENST00000540457.1_Intron|UQCC_ENST00000359226.2_Intron|UQCC_ENST00000491125.1_5'UTR|UQCC_ENST00000542501.1_Intron|UQCC_ENST00000374384.2_Missense_Mutation_p.L135Q|UQCC_ENST00000374380.2_Missense_Mutation_p.L67Q|UQCC_ENST00000349714.5_Intron|UQCC_ENST00000374377.5_Intron			Q9NVA1	UQCC_HUMAN		135				LR -> MG (in Ref. 2; BAB14217).		cytoplasmic membrane-bounded vesicle				breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TAACTTACTTAGAAAGAATTC	0.343000													64	112					0	0	0.870114	0	0
NNT	23530	broad.mit.edu	37	5	43609438	43609438	+	Silent	SNP	T	T	A	rs143463864	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:43609438T>A	ENST00000264663.5	+	2	362	c.141T>A	c.(139-141)ccT>ccA	p.P47P	NNT_ENST00000344920.4_Silent_p.P47P|NNT_ENST00000512996.2_Intron	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	47					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	GTAAAGCGCCTGTAAAACCAG	0.383000													3	107					0	0	0.115264	0	0
LPP	4026	broad.mit.edu	37	3	188590487	188590487	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:188590487A>G	ENST00000312675.4	+	10	1892	c.1646A>G	c.(1645-1647)cAg>cGg	p.Q549R	LPP_ENST00000543006.1_Missense_Mutation_p.Q549R	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	549	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCCCCGGGCCAGGAGGAGACT	0.547000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								31	123					0	0	0.827153	0	0
UMODL1	89766	broad.mit.edu	37	21	43519186	43519186	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:43519186A>G	ENST00000400427.1	+	7	1262	c.866A>G	c.(865-867)cAg>cGg	p.Q289R	UMODL1_ENST00000408989.2_Missense_Mutation_p.Q361R|UMODL1_ENST00000408910.2_Missense_Mutation_p.Q361R|UMODL1_ENST00000400424.1_Missense_Mutation_p.Q289R	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	361	EGF-like 1; calcium-binding (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						ACACAGAGCCAGGCACTGGCA	0.577000													25	73					0	0	0.667858	0	0
PIK3C3	5289	broad.mit.edu	37	18	39609379	39609379	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:39609379C>T	ENST00000262039.4	+	15	1767	c.1681C>T	c.(1681-1683)Cgc>Tgc	p.R561C	PIK3C3_ENST00000398870.3_Missense_Mutation_p.R498C|PIK3C3_ENST00000593098.1_Missense_Mutation_p.R46C	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	561					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						GGCAGTACAACGCGAAAGTGG	0.408000										TSP Lung(28;0.18)			34	82					0	0	0.779181	0	0
KPTN	11133	broad.mit.edu	37	19	47980969	47980969	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:47980969A>C	ENST00000338134.3	-	9	964	c.857T>G	c.(856-858)gTg>gGg	p.V286G	KPTN_ENST00000536339.1_Missense_Mutation_p.V46G	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	286					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			breast(1)|lung(3)|ovary(2)|pancreas(2)	8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		TCACCGATACACCACTGCTGG	0.517000													11	33					0	0	0.387290	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77331255	77331255	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:77331255G>A	ENST00000282849.5	-	18	3150	c.2732C>T	c.(2731-2733)tCa>tTa	p.S911L		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	911					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ACTGCAGAATGAGGAATTGAC	0.393000													68	106					0	0	0.870114	0	0
KDM2A	22992	broad.mit.edu	37	11	66999421	66999421	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:66999421C>T	ENST00000529006.2	+	12	1915	c.1469C>T	c.(1468-1470)gCt>gTt	p.A490V	KDM2A_ENST00000398645.2_Missense_Mutation_p.A490V|KDM2A_ENST00000526258.1_3'UTR	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						GCTCTCATTGCTGATGTAAAG	0.458000													146	287					0	0	0.870114	0	0
N4BP1	9683	broad.mit.edu	37	16	48595100	48595100	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:48595100G>T	ENST00000262384.3	-	2	1690	c.1454C>A	c.(1453-1455)aCa>aAa	p.T485K	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	485					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TTCAGGGTCTGTGTTACAAAT	0.418000													50	100					4.10826e-27	4.52286e-27	0.870114	1	0
SPEN	23013	broad.mit.edu	37	1	16261593	16261593	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:16261593T>C	ENST00000375759.3	+	11	9062	c.8858T>C	c.(8857-8859)aTt>aCt	p.I2953T		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2953					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACCCCAAGCATTGTCACCACA	0.597000													21	19					0	0	0.667858	0	0
CCDC178	374864	broad.mit.edu	37	18	30825388	30825388	+	Missense_Mutation	SNP	G	G	A	rs146565345	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:30825388G>A	ENST00000383096.3	-	15	1596	c.1414C>T	c.(1414-1416)Cgg>Tgg	p.R472W	CCDC178_ENST00000402325.1_Missense_Mutation_p.R472W|CCDC178_ENST00000403303.1_Missense_Mutation_p.R472W|CCDC178_ENST00000583930.1_Missense_Mutation_p.R472W|CCDC178_ENST00000406524.2_Missense_Mutation_p.R472W|CCDC178_ENST00000579947.1_Missense_Mutation_p.R472W|CCDC178_ENST00000300227.8_Missense_Mutation_p.R472W|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178																		GATTTTTTCCGTATGCTGTAA	0.234000													12	21					0	0	0.387290	0	0
ZIK1	284307	broad.mit.edu	37	19	58096319	58096319	+	Splice_Site	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:58096319G>A	ENST00000597850.1	+	2	248		c.e2-1		ZIK1_ENST00000536878.2_Intron|ZIK1_ENST00000599456.1_Intron|ZIK1_ENST00000598726.1_Intron|ZIK1_ENST00000307468.4_Intron	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCTTTCCACAGGTTACTGTGT	0.552000													39	82					0	0	0.870114	0	0
RASL10B	91608	broad.mit.edu	37	17	34068079	34068079	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:34068079A>G	ENST00000268864.3	+	4	744	c.367A>G	c.(367-369)Atc>Gtc	p.I123V		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	123	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGAGACGCCCATCATCATCGT	0.647000													25	38					0	0	0.706142	0	0
PYGO1	26108	broad.mit.edu	37	15	55841138	55841138	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:55841138T>C	ENST00000302000.6	-	2	199	c.105A>G	c.(103-105)ccA>ccG	p.P35P	PYGO1_ENST00000563719.1_Silent_p.P35P	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	35					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		TTTTCTTATCTGGGCTTCCTA	0.368000													48	91					0	0	0.870114	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13797837	13797837	+	Missense_Mutation	SNP	C	C	T	rs150559783		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:13797837C>T	ENST00000378106.5	+	11	1138	c.1019C>T	c.(1018-1020)cCg>cTg	p.P340L	NDUFAF5_ENST00000475968.1_3'UTR|NDUFAF5_ENST00000463598.1_Missense_Mutation_p.P312L	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	340					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										CTTATGCCACCGGGGAAAAAA	0.318000													10	285					0	0	0.411799	0	0
RORC	6097	broad.mit.edu	37	1	151789698	151789698	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151789698G>A	ENST00000356728.6	-	2	220	c.66C>T	c.(64-66)taC>taT	p.Y22Y	RORC_ENST00000318247.6_Silent_p.Y43Y|RORC_ENST00000392697.3_Silent_p.Y97Y	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	43	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGATAACCCCGTAGTGGATCC	0.532000													22	57					0	0	0.639603	0	0
OR10G7	390265	broad.mit.edu	37	11	123909474	123909474	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123909474T>A	ENST00000330487.5	-	1	243	c.235A>T	c.(235-237)Atg>Ttg	p.M79L		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GTCATCAGCATTTTGGGCACC	0.537000													21	298					0	0	0.681144	0	0
MYO15A	51168	broad.mit.edu	37	17	18059537	18059537	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:18059537C>T	ENST00000205890.5	+	48	8826	c.8488C>T	c.(8488-8490)Ccc>Tcc	p.P2830S	MYO15A_ENST00000418233.3_Missense_Mutation_p.P94S|MYO15A_ENST00000585180.1_Missense_Mutation_p.A92V	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2830	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGTGACCATGCCCTCCCAGAA	0.562000													35	78					0	0	0.796494	0	0
ROBO2	6092	broad.mit.edu	37	3	77542422	77542422	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:77542422T>A	ENST00000461745.1	+	5	1595	c.695T>A	c.(694-696)aTt>aAt	p.I232N	ROBO2_ENST00000487694.3_Missense_Mutation_p.I248N|ROBO2_ENST00000332191.8_Missense_Mutation_p.I232N	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	232	Ig-like C2-type 3.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGGAGGCCAATTAACCAGGTG	0.378000													68	55					0	0	0.870114	0	0
TRIB1	10221	broad.mit.edu	37	8	126445606	126445606	+	Translation_Start_Site	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:126445606G>A	ENST00000520847.1	+	0	164				TRIB1_ENST00000521778.1_3'UTR|TRIB1_ENST00000311922.3_Silent_p.Q136Q			Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1						JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CTTACATCCAGCTGCCATCGC	0.507000													10	452					0	0	0.411799	0	0
TMTC1	83857	broad.mit.edu	37	12	29920872	29920872	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:29920872T>C	ENST00000256062.5	-	2	588	c.115A>G	c.(115-117)Acg>Gcg	p.T39A	TMTC1_ENST00000551659.1_Missense_Mutation_p.T147A|TMTC1_ENST00000552618.1_Missense_Mutation_p.T147A|TMTC1_ENST00000539277.1_Missense_Mutation_p.T147A|TMTC1_ENST00000381224.2_Missense_Mutation_p.T39A	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	147						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AGCAATGCCGTTACAAAAGCA	0.368000													39	85					0	0	0.859065	0	0
ABCG4	64137	broad.mit.edu	37	11	119025497	119025497	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:119025497G>A	ENST00000307417.3	+	6	922	c.558G>A	c.(556-558)acG>acA	p.T186T	ABCG4_ENST00000449422.2_Silent_p.T186T|ABCG4_ENST00000531739.1_Silent_p.T186T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	186	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		AGATCCTGACGGCACTGGGCC	0.647000													46	117					0	0	0.870114	0	0
TBC1D3	729873	broad.mit.edu	37	17	36352528	36352528	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:36352528T>C	ENST00000537432.1	-	4	322		c.e4-2		RP11-1407O15.2_ENST00000544906.1_Splice_Site|RP11-1407O15.2_ENST00000312412.4_Splice_Site			Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3							intracellular	Rab GTPase activator activity			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CACACTGACCTGGCAGACAAT	0.413000													9	183					0	0	0.361761	0	0
HEATR4	399671	broad.mit.edu	37	14	73987615	73987615	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:73987615G>A	ENST00000553558.1	-	4	1331	c.1010C>T	c.(1009-1011)cCc>cTc	p.P337L	HEATR4_ENST00000560393.1_Missense_Mutation_p.P290L|HEATR4_ENST00000334988.2_Missense_Mutation_p.P337L	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCCAGCTCGGGGAGTCACCTG	0.532000													83	117					0	0	0.870114	0	0
ELAC2	60528	broad.mit.edu	37	17	12905673	12905673	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:12905673C>T	ENST00000338034.4	-	14	1461	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	ELAC2_ENST00000395962.2_Missense_Mutation_p.E389K|ELAC2_ENST00000426905.3_Missense_Mutation_p.E368K	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	408					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						GTGGGGCCCTCCTTCTGAAAG	0.572000													16	29					0	0	0.557998	0	0
PLSCR4	57088	broad.mit.edu	37	3	145917688	145917688	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:145917688G>A	ENST00000354952.2	-	6	776	c.536C>T	c.(535-537)aCt>aTt	p.T179I	PLSCR4_ENST00000493382.1_Missense_Mutation_p.T179I|PLSCR4_ENST00000446574.2_Missense_Mutation_p.T179I|PLSCR4_ENST00000433593.2_Intron|PLSCR4_ENST00000383083.2_Intron	NM_020353.2	NP_065086.2	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4	179					blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			kidney(1)|large_intestine(6)|lung(9)|urinary_tract(1)	17						CATACAATCAGTGACCCGGAG	0.493000													3	78					0	0	0.115264	0	0
BMP4	652	broad.mit.edu	37	14	54417384	54417384	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:54417384C>T	ENST00000245451.4	-	4	986	c.593G>A	c.(592-594)cGa>cAa	p.R198Q	BMP4_ENST00000558984.1_Missense_Mutation_p.R198Q|BMP4_ENST00000559087.1_Missense_Mutation_p.R198Q|BMP4_ENST00000417573.1_Missense_Mutation_p.R198Q	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	198					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						GTCCAGTAGTCGTGTGATGAG	0.562000													40	75					0	0	0.834066	0	0
DSCAM	1826	broad.mit.edu	37	21	41416060	41416060	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:41416060T>C	ENST00000400454.1	-	31	5805	c.5328A>G	c.(5326-5328)gcA>gcG	p.A1776A		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1776					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTACTGATCCTGCAGCCCTGG	0.632000													6	119					0	0	0.278610	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581504	232581504	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:232581504T>C	ENST00000366630.1	-	10	3482	c.3124A>G	c.(3124-3126)Atg>Gtg	p.M1042V	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.M1042V|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.M116V			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1042					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TATTCCACCATAGGGATCCGG	0.572000													6	272					0	0	0.248553	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554727	140554727	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140554727A>C	ENST00000231137.3	+	1	2485	c.2311A>C	c.(2311-2313)Aac>Cac	p.N771H		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		771					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATTATCCCCAACCTGCTACC	0.493000													10	69					0	0	0.608945	0	0
PEX7	5191	broad.mit.edu	37	6	137191121	137191121	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:137191121T>C	ENST00000541292.1	+	7	813	c.727T>C	c.(727-729)Tat>Cat	p.Y243H	PEX7_ENST00000318471.4_Missense_Mutation_p.Y243H			O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	243					ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding			lung(7)|prostate(1)	8	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		TGGTCATACCTATGCTATTAG	0.338000													170	265					0	0	0.870114	0	0
PDCD11	22984	broad.mit.edu	37	10	105173796	105173796	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:105173796G>C	ENST00000369797.3	+	10	1353	c.1259G>C	c.(1258-1260)aGa>aCa	p.R420T		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	420	S1 motif 4.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CACAAGTGTAGAATTATTGAC	0.453000													6	233					0	0	0.217242	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42132730	42132730	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:42132730T>C	ENST00000382448.4	+	8	793	c.784T>C	c.(784-786)Tct>Cct	p.S262P	JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.S31P|PLA2G4B_ENST00000452633.1_Missense_Mutation_p.S31P|JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.S262P	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		31	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						AGTGACCCCCTCTGACTGCTA	0.622000													27	55					0	0	0.706142	0	0
NPAS4	266743	broad.mit.edu	37	11	66192164	66192164	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:66192164T>C	ENST00000311034.2	+	7	1979	c.1803T>C	c.(1801-1803)gaT>gaC	p.D601D		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	601					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TCTCTGTGGATGTCCCCCTGG	0.582000													77	106					0	0	0.870114	0	0
KCNT2	343450	broad.mit.edu	37	1	196274362	196274362	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:196274362A>G	ENST00000367433.5	-	21	2625		c.e21+1		KCNT2_ENST00000294725.8_Splice_Site|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Splice_Site|KCNT2_ENST00000498426.1_Splice_Site			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2							voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GTGGGGTCTTACCTTTTCCAG	0.333000													41	63					0	0	0.819951	0	0
XKR4	114786	broad.mit.edu	37	8	56436132	56436132	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:56436132C>T	ENST00000327381.5	+	3	1399	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	433						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGATTGTGTTCGACATGGTGG	0.443000													23	419					0	0	0.639603	0	0
FAM184A	79632	broad.mit.edu	37	6	119301393	119301393	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:119301393C>T	ENST00000338891.7	-	10	2654	c.2211G>A	c.(2209-2211)gaG>gaA	p.E737E	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Silent_p.E617E|FAM184A_ENST00000368475.4_Silent_p.E617E|FAM184A_ENST00000521531.1_Silent_p.E737E	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	737										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GATGTTGCTCCTCTAATTCTT	0.418000													66	118					0	0	0.870114	0	0
ABL2	27	broad.mit.edu	37	1	179090956	179090956	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:179090956A>G	ENST00000502732.1	-	5	937	c.734T>C	c.(733-735)gTa>gCa	p.V245A	ABL2_ENST00000507173.1_Missense_Mutation_p.V224A|ABL2_ENST00000511413.1_Missense_Mutation_p.V245A|ABL2_ENST00000344730.3_Missense_Mutation_p.V230A|ABL2_ENST00000504405.1_Missense_Mutation_p.V209A|ABL2_ENST00000367623.4_Missense_Mutation_p.V224A|ABL2_ENST00000392043.3_Missense_Mutation_p.V224A|ABL2_ENST00000512653.1_Missense_Mutation_p.V230A|ABL2_ENST00000408940.3_Missense_Mutation_p.V209A	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	245	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GTGATGGTGTACAAGCTCTGC	0.463000			T	ETV6	AML								20	41					0	0	0.639603	0	0
TMEM38B	55151	broad.mit.edu	37	9	108536277	108536277	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:108536277C>A	ENST00000374688.1	+	6	1340	c.630C>A	c.(628-630)tcC>tcA	p.S210S	TMEM38B_ENST00000374692.3_Silent_p.S264S			Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	264						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity	p.S264S(1)		kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						AGTCACCTTCCAATGGCGTTG	0.408000													66	49					6.26901e-30	6.94719e-30	0.870114	1	0
FAM83C	128876	broad.mit.edu	37	20	33875605	33875605	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:33875605G>A	ENST00000374408.3	-	4	1073	c.977C>T	c.(976-978)cCt>cTt	p.P326L		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	326										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TAGGGCCACAGGGGGAGGACG	0.657000													5	5					0	0	0.217242	0	0
KLHL7	55975	broad.mit.edu	37	7	23191797	23191797	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:23191797A>G	ENST00000322231.7	+	8	1329	c.839A>G	c.(838-840)cAa>cGa	p.Q280R	KLHL7_ENST00000545443.1_Missense_Mutation_p.Q280R|KLHL7_ENST00000409689.1_Missense_Mutation_p.Q254R|KLHL7_ENST00000542558.1_Missense_Mutation_p.Q77R|KLHL7_ENST00000539124.1_Missense_Mutation_p.Q226R|KLHL7_ENST00000339077.4_Missense_Mutation_p.Q302R			Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7	302						Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGAGGCTCTCAACCACAGTCT	0.393000													51	130					0	0	0.870114	0	0
C1orf122	127687	broad.mit.edu	37	1	38274716	38274716	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:38274716G>A	ENST00000373043.1	+	2	1821	c.115G>A	c.(115-117)Gat>Aat	p.D39N	C1orf122_ENST00000468084.1_Missense_Mutation_p.D39N|C1orf122_ENST00000525096.2_Intron|C1orf122_ENST00000446260.2_Silent_p.R130R|C1orf122_ENST00000373042.4_Missense_Mutation_p.D102N			Q6ZSJ8	CA122_HUMAN	chromosome 1 open reading frame 122	102										kidney(2)|lung(2)	4	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0393)				CTTTCCAAAGGATGCTGGCGA	0.612000													41	39					0	0	0.870114	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388049	56388049	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:56388049C>A	ENST00000355701.3	-	20	4393	c.3523G>T	c.(3523-3525)Ggt>Tgt	p.G1175C	BZRAP1_ENST00000343736.4_Missense_Mutation_p.G1175C|BZRAP1_ENST00000268893.6_Missense_Mutation_p.G1115C	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1175						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCTTCTCACCCAGGGTAGAT	0.667000													7	24					0.27861	0.279609	0.278610	1	0
NR1H4	9971	broad.mit.edu	37	12	100957204	100957204	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:100957204G>A	ENST00000548884.1	+	11	1897	c.1356G>A	c.(1354-1356)atG>atA	p.M452I	NR1H4_ENST00000392986.3_Missense_Mutation_p.M456I|NR1H4_ENST00000188403.7_Missense_Mutation_p.M462I|NR1H4_ENST00000549996.1_Missense_Mutation_p.M405I|NR1H4_ENST00000551379.1_Missense_Mutation_p.M466I	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	466	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						AGATGCTGATGTCATGGAGAG	0.493000													104	184					0	0	0.870114	0	0
DHRS4	10901	broad.mit.edu	37	14	24424296	24424296	+	Missense_Mutation	SNP	G	G	A	rs141661758		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:24424296G>A	ENST00000313250.5	+	2	384	c.181G>A	c.(181-183)Gtc>Atc	p.V61I	DHRS4_ENST00000558581.1_Missense_Mutation_p.V61I|DHRS4_ENST00000558263.1_Missense_Mutation_p.V61I|DHRS4_ENST00000397073.2_Missense_Mutation_p.V43I|DHRS4_ENST00000543741.2_Missense_Mutation_p.V61I|DHRS4_ENST00000421831.1_Missense_Mutation_p.V43I|DHRS4_ENST00000397074.3_Missense_Mutation_p.V61I|DHRS4_ENST00000397075.3_Missense_Mutation_p.V61I|DHRS4_ENST00000382761.3_Missense_Mutation_p.V43I|DHRS4_ENST00000308178.8_Missense_Mutation_p.V43I|DHRS4_ENST00000559632.1_Missense_Mutation_p.V61I	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4	61						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	CCATGTGGTCGTCAGCAGCCG	0.657000													48	26					0	0	0.870114	0	0
MORC1	27136	broad.mit.edu	37	3	108836867	108836867	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:108836867G>A	ENST00000232603.5	-	1	122	c.40C>T	c.(40-42)Cgt>Tgt	p.R14C	MORC1_ENST00000483760.1_Missense_Mutation_p.R14C	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	14					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AAATCCAGACGCAGCTGGGCC	0.657000													3	10					0	0	0.150653	0	0
TMPRSS4	56649	broad.mit.edu	37	11	117984053	117984053	+	Silent	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:117984053G>T	ENST00000534111.1	+	9	1072	c.807G>T	c.(805-807)ctG>ctT	p.L269L	TMPRSS4_ENST00000522307.1_Silent_p.L124L|TMPRSS4_ENST00000523251.1_Silent_p.L231L|TMPRSS4_ENST00000518413.2_3'UTR|TMPRSS4_ENST00000437212.3_Silent_p.L271L|TMPRSS4_ENST00000522824.1_Silent_p.L266L	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022.1|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	271	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TCCCATCCCTGGCTGTGGCCA	0.537000													6	181					0.00116845	0.00119258	0.217242	1	0
CES5A	221223	broad.mit.edu	37	16	55886920	55886920	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:55886920C>T	ENST00000521992.1	-	11	1378	c.1233G>A	c.(1231-1233)ttG>ttA	p.L411L	CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000290567.9_Silent_p.L382L|CES5A_ENST00000319165.9_Silent_p.L382L|CES5A_ENST00000520435.1_Silent_p.L352L|CES5A_ENST00000518005.1_Silent_p.L276L	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	382						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CCACAAGGTGCAAATACTGAG	0.473000													5	124					0	0	0.248553	0	0
INPP4B	8821	broad.mit.edu	37	4	143007357	143007357	+	Silent	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:143007357G>T	ENST00000513000.1	-	25	2860	c.2427C>A	c.(2425-2427)ctC>ctA	p.L809L	INPP4B_ENST00000508116.1_Silent_p.L809L|INPP4B_ENST00000262992.4_Silent_p.L809L|INPP4B_ENST00000308502.4_Silent_p.L809L|INPP4B_ENST00000509777.1_Silent_p.L809L	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	809					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TATTTTGAAGGAGATTTTCTA	0.338000													18	37					2.4624e-09	2.58875e-09	0.575678	1	0
CSMD1	64478	broad.mit.edu	37	8	3855604	3855604	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:3855604G>A	ENST00000602557.1	-	5	1194	c.639C>T	c.(637-639)cgC>cgT	p.R213R	CSMD1_ENST00000520002.1_Silent_p.R213R|CSMD1_ENST00000539096.1_Silent_p.R213R|CSMD1_ENST00000542608.1_Silent_p.R213R|CSMD1_ENST00000602723.1_Silent_p.R213R|CSMD1_ENST00000537824.1_Silent_p.R213R|CSMD1_ENST00000400186.3_Silent_p.R213R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	213	CUB 2.					integral to membrane		p.R213R(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTGGTCCCGCGTAAGGTTC	0.567000													4	10					0	0	0.150653	0	0
MSRB3	253827	broad.mit.edu	37	12	65857074	65857074	+	Missense_Mutation	SNP	C	C	T	rs144038296	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:65857074C>T	ENST00000308259.5	+	7	804	c.530C>T	c.(529-531)cCg>cTg	p.P177L	MSRB3_ENST00000355192.3_Missense_Mutation_p.P184L|MSRB3_ENST00000535664.1_Missense_Mutation_p.P177L	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	184					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GTCGCCAGCCCGGCCCAGGCA	0.483000													5	94					0	0	0.184627	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86542277	86542277	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:86542277G>T	ENST00000450689.2	-	14	2160	c.1975C>A	c.(1975-1977)Cct>Act	p.P659T	KIAA1324L_ENST00000444627.1_Silent_p.G612G|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.P419T|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.P492T	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	659						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TTACTCCCAGGCCCGCATGGA	0.438000													29	56					3.99451e-17	4.30178e-17	0.740014	1	0
SSH3	54961	broad.mit.edu	37	11	67075160	67075160	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:67075160C>T	ENST00000308127.4	+	7	921	c.743C>T	c.(742-744)gCt>gTt	p.A248V	SSH3_ENST00000532181.1_Intron|SSH3_ENST00000308298.7_Missense_Mutation_p.A248V|SSH3_ENST00000376757.5_Missense_Mutation_p.A248V	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	248					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GAGTGGACGGCTATGGCCGAC	0.652000													13	28					0	0	0.639603	0	0
GP2	2813	broad.mit.edu	37	16	20327330	20327330	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:20327330T>C	ENST00000302555.5	-	9	1598	c.1449A>G	c.(1447-1449)gtA>gtG	p.V483V	GP2_ENST00000381360.5_Silent_p.V339V|GP2_ENST00000381362.4_Silent_p.V486V|GP2_ENST00000341642.5_Silent_p.V336V			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	486	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CGATGGCCGGTACTTCACTGC	0.478000													7	121					0	0	0.248553	0	0
IQCK	124152	broad.mit.edu	37	16	19775436	19775436	+	Splice_Site	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:19775436T>G	ENST00000320394.6	+	7	1304		c.e7+2		IQCK_ENST00000541926.1_Splice_Site|CTD-2380F24.1_ENST00000565817.1_RNA|CTD-2380F24.1_ENST00000564490.1_RNA|IQCK_ENST00000433597.2_Splice_Site|IQCK_ENST00000564186.1_Splice_Site|CTD-2380F24.1_ENST00000568843.1_RNA|IQCK_ENST00000562762.1_Splice_Site	NM_153208.1	NP_694940.1	Q8N0W5	IQCK_HUMAN	IQ motif containing K											kidney(1)|large_intestine(2)|lung(2)|skin(1)	6						AAAGCAACAGTGAGTATGACA	0.388000													14	33					0	0	0.457914	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32893939	32893939	+	RNA	SNP	C	C	A	rs141032430	by1000genomes	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:32893939C>A	ENST00000330048.5	-	0	1318					NR_003083.2																						GTCTTCATGGCGGAAGATCTC	0.597000													7	224					8.16721e-17	8.78419e-17	0.750413	1	0
LNX2	222484	broad.mit.edu	37	13	28155884	28155884	+	Translation_Start_Site	SNP	C	C	T	rs112460239		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:28155884C>T	ENST00000316334.3	-	0	86					NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2								zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		TTCCACTTCACGCTTGGTTTC	0.368000													28	59					0	0	0.681144	0	0
RMND5B	64777	broad.mit.edu	37	5	177575020	177575020	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:177575020G>A	ENST00000515098.1	+	12	1520	c.1169G>A	c.(1168-1170)cGc>cAc	p.R390H	RMND5B_ENST00000313386.4_Missense_Mutation_p.R390H|RMND5B_ENST00000542098.1_Missense_Mutation_p.R377H			Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	390								p.R390H(1)		endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	17	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGGGAAACGCATCATATTC	0.532000													48	91					0	0	0.870114	0	0
FAM35A	54537	broad.mit.edu	37	10	88911131	88911131	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:88911131T>C	ENST00000298786.4	+	3	134	c.20T>C	c.(19-21)gTc>gCc	p.V7A	FAM35A_ENST00000298784.1_Missense_Mutation_p.V7A			Q86V20	FA35A_HUMAN	family with sequence similarity 35, member A	7										endometrium(2)|kidney(2)|large_intestine(5)|lung(1)|ovary(2)|prostate(2)|skin(2)	16						GGATCTCAAGTCCACATTTTT	0.338000													37	69					0	0	0.812448	0	0
JADE3	9767	broad.mit.edu	37	X	46913820	46913820	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:46913820A>G	ENST00000218343.4	+	9	1531	c.1233A>G	c.(1231-1233)gtA>gtG	p.V411V	PHF16_ENST00000397189.1_Silent_p.V411V	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		411					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						ATTCCTTGGTACGAGTGGAAG	0.522000													30	14					0	0	0.804634	0	0
CRYM	1428	broad.mit.edu	37	16	21272583	21272583	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:21272583T>C	ENST00000219599.3	-	9	1137	c.872A>G	c.(871-873)aAg>aGg	p.K291R	CRYM_ENST00000415987.2_Missense_Mutation_p.K249R|CRYM_ENST00000543948.1_Missense_Mutation_p.K291R|CRYM_ENST00000396023.2_Missense_Mutation_p.K291R	NM_001888.3	NP_001879.1	Q14894	CRYM_HUMAN	crystallin, mu	291					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity			large_intestine(1)|lung(3)	4				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	ACCCAAAGACTTGAACACGGT	0.512000													36	62					0	0	0.827153	0	0
XPOT	11260	broad.mit.edu	37	12	64812734	64812734	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:64812734T>C	ENST00000332707.5	+	6	878	c.349T>C	c.(349-351)Tat>Cat	p.Y117H		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	117	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		TGTTACAGAGTATCTCACTAA	0.438000													4	179					0	0	0.184627	0	0
CPEB4	80315	broad.mit.edu	37	5	173370038	173370038	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:173370038A>G	ENST00000265085.5	+	4	2722	c.1268A>G	c.(1267-1269)tAt>tGt	p.Y423C	CPEB4_ENST00000520867.1_Intron|CPEB4_ENST00000519467.1_3'UTR|CPEB4_ENST00000522336.1_Intron|CPEB4_ENST00000334035.5_Missense_Mutation_p.Y406C|CPEB4_ENST00000519835.1_Intron|CPEB4_ENST00000517880.1_Intron	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	423							nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCAAGGACATATGGGCGAAGG	0.348000													99	191					0	0	0.870114	0	0
RNF43	54894	broad.mit.edu	37	17	56492887	56492887	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:56492887T>C	ENST00000584437.1	-	1	2007	c.52A>G	c.(52-54)Atg>Gtg	p.M18V	RNF43_ENST00000500597.2_Missense_Mutation_p.M18V|RNF43_ENST00000407977.2_Missense_Mutation_p.M18V|RNF43_ENST00000577716.1_Missense_Mutation_p.M18V|RNF43_ENST00000583753.1_Missense_Mutation_p.M18V|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000581868.1_Intron			Q68DV7	RNF43_HUMAN	ring finger protein 43	18						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGGTAGCCATCAGCAGCCAG	0.557000													5	22					0	0	0.639603	0	0
THTPA	79178	broad.mit.edu	37	14	24026241	24026241	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:24026241T>C	ENST00000288014.6	+	1	1011	c.275T>C	c.(274-276)cTc>cCc	p.L92P	THTPA_ENST00000556015.1_Missense_Mutation_p.L92P|RP11-66N24.4_ENST00000556354.1_RNA|RP11-66N24.4_ENST00000555446.1_RNA|THTPA_ENST00000404535.3_Missense_Mutation_p.L92P|RP11-66N24.4_ENST00000553985.1_RNA|THTPA_ENST00000554789.1_Missense_Mutation_p.L92P|THTPA_ENST00000554970.1_Missense_Mutation_p.L92P			Q9BU02	THTPA_HUMAN	thiamine triphosphatase	92					dephosphorylation|generation of precursor metabolites and energy|thiamine metabolic process	cytosol|nucleolus|soluble fraction	thiamin-triphosphatase activity			large_intestine(1)|prostate(2)	3	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00643)	Thiamine(DB00152)	GTGGCCCAACTCTGTAAGGTG	0.577000													28	74					0	0	0.750413	0	0
CUBN	8029	broad.mit.edu	37	10	17164806	17164806	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:17164806A>G	ENST00000377833.4	-	6	646	c.581T>C	c.(580-582)aTg>aCg	p.M194T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	194	EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTAACTTCCCATTGTATTAAC	0.368000													7	106					0	0	0.307466	0	0
SPTBN4	57731	broad.mit.edu	37	19	41029412	41029412	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:41029412C>T	ENST00000352632.3	+	17	3809	c.3723C>T	c.(3721-3723)caC>caT	p.H1241H	SPTBN4_ENST00000595535.1_Silent_p.H1241H|SPTBN4_ENST00000344104.3_Silent_p.H1241H|SPTBN4_ENST00000338932.3_Silent_p.H1241H|SPTBN4_ENST00000598249.1_Silent_p.H1241H			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1241					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAAACAGCACCGTGACTTTC	0.632000													19	31					0	0	0.557998	0	0
TRGV2	6974	broad.mit.edu	37	7	38402604	38402604	+	RNA	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:38402604T>G	ENST00000426402.2	-	0	404																											AACCTTGGAGTTGTAGGAGTC	0.458000													19	122					0	0	0.740014	0	0
SLC26A7	115111	broad.mit.edu	37	8	92378916	92378916	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:92378916T>C	ENST00000276609.3	+	14	1836	c.1597T>C	c.(1597-1599)Tgt>Cgt	p.C533R	SLC26A7_ENST00000523719.1_Missense_Mutation_p.C533R|SLC26A7_ENST00000309536.2_Missense_Mutation_p.C533R|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	533	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GGAAAATGCCTGTAATCAGCC	0.333000													97	191					0	0	0.870114	0	0
SPRR3	6707	broad.mit.edu	37	1	152975911	152975911	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:152975911A>G	ENST00000331860.3	+	3	565	c.415A>G	c.(415-417)Acc>Gcc	p.T139A	SPRR3_ENST00000542696.1_Missense_Mutation_p.T131A|SPRR3_ENST00000295367.4_Missense_Mutation_p.T139A	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	139	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAAGGATACACCAAAGTTCC	0.527000													16	37					0	0	0.479597	0	0
HECW2	57520	broad.mit.edu	37	2	197157345	197157345	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:197157345T>C	ENST00000260983.2	-	14	3126	c.2944A>G	c.(2944-2946)Aac>Gac	p.N982D	HECW2_ENST00000409111.1_Missense_Mutation_p.N626D	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	982	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AGCTGTTTGTTCGCGAACATG	0.542000													43	115					0	0	0.840704	0	0
TMOD4	29765	broad.mit.edu	37	1	151147019	151147019	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151147019A>G	ENST00000416280.2	-	3	227	c.128T>C	c.(127-129)aTg>aCg	p.M43T				Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	84					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGCAGGAGCATGTTCTTAGG	0.562000													112	195					0	0	0.870114	0	0
FLAD1	80308	broad.mit.edu	37	1	154965266	154965266	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:154965266A>G	ENST00000368432.1	+	7	1518	c.1341A>G	c.(1339-1341)taA>taG	p.*447*	FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000292180.3_Intron|FLAD1_ENST00000368428.1_Intron|FLAD1_ENST00000315144.10_Intron	NM_001184891.1	NP_001171820.1	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	0	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACCGAGGGTAAGGGTATTAGG	0.522000													57	143					0	0	0.870114	0	0
SMARCC1	6599	broad.mit.edu	37	3	47677513	47677513	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:47677513T>C	ENST00000254480.5	-	23	2609	c.2491_splice	c.e23+1	p.S830_splice	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	830	Glu-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCAAATTACCTGATTTGGTAT	0.323000													40	123					0	0	0.827153	0	0
EP300	2033	broad.mit.edu	37	22	41574312	41574312	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:41574312A>G	ENST00000263253.7	+	31	7816	c.6597A>G	c.(6595-6597)ccA>ccG	p.P2199P	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2199	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GAGCAGGGCCAGGAATAGGCC	0.537000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				22	17					0	0	0.592651	0	0
KRT2	3849	broad.mit.edu	37	12	53045390	53045390	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:53045390A>G	ENST00000309680.3	-	1	558	c.537T>C	c.(535-537)cgT>cgC	p.R179R		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	179	Coil 1A.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		TGATCTGCTCACGCTCTTGGG	0.522000													16	200					0	0	0.575678	0	0
LINC00886	730091	broad.mit.edu	37	3	156528100	156528100	+	RNA	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:156528100T>C	ENST00000472943.1	-	0	148					NR_038387.1																						CTTAATAACATCTGCCTTCCT	0.483000													112	36					0	0	0.870114	0	0
SEPP1	6414	broad.mit.edu	37	5	42801175	42801175	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:42801175C>T	ENST00000514985.1	-	5	1049	c.793G>A	c.(793-795)Gca>Aca	p.A265T	CCDC152_ENST00000361970.5_3'UTR|SEPP1_ENST00000509276.1_5'UTR|SEPP1_ENST00000506577.1_Missense_Mutation_p.A265T|SEPP1_ENST00000511224.1_Missense_Mutation_p.A265T|SEPP1_ENST00000507920.1_Silent_p.Q154Q	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	265					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						TCTTCACTTGCTGGCATATCT	0.453000													30	67					0	0	0.717897	0	0
SERPINB13	5275	broad.mit.edu	37	18	61256926	61256926	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:61256926A>T	ENST00000344731.5	+	3	304	c.202A>T	c.(202-204)Ata>Tta	p.I68L	SERPINB13_ENST00000269489.5_Missense_Mutation_p.I68L	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	68					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GAGCTCAAGAATAAAGGCTGA	0.403000													5	51					0	0	0.248553	0	0
GPR156	165829	broad.mit.edu	37	3	119885981	119885981	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:119885981A>G	ENST00000464295.1	-	10	2788	c.2343T>C	c.(2341-2343)acT>acC	p.T781T	GPR156_ENST00000461057.1_Silent_p.T777T|GPR156_ENST00000315843.3_Silent_p.T781T			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	781						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GCTCAGGGTCAGTGTCTGATG	0.557000													6	313					0	0	0.307466	0	0
KRT16P2	400578	broad.mit.edu	37	17	16734765	16734765	+	RNA	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:16734765C>T	ENST00000579062.1	-	0	550																											CTCCTTCAGGCCTTCCATCTG	0.632000													22	49					0	0	0.693898	0	0
IFNA7	3444	broad.mit.edu	37	9	21201943	21201943	+	Silent	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:21201943A>T	ENST00000239347.3	-	1	261	c.222T>A	c.(220-222)acT>acA	p.T74T		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	74					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGATGGCTTGAGTCTTCTGGA	0.483000													90	67					0	0	0.870114	0	0
DCHS1	8642	broad.mit.edu	37	11	6646021	6646021	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:6646021C>A	ENST00000299441.3	-	20	7636	c.7225G>T	c.(7225-7227)Ggt>Tgt	p.G2409C		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2409	Cadherin 23.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAATGTGACCGTTGGCACCT	0.562000													10	20					0.0809354	0.0816155	0.387290	1	0
UPRT	139596	broad.mit.edu	37	X	74520734	74520734	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:74520734G>A	ENST00000373379.1	+	6	922	c.757G>A	c.(757-759)Gtt>Att	p.V253I	UPRT_ENST00000530743.1_Missense_Mutation_p.V117I|UPRT_ENST00000373383.4_Missense_Mutation_p.V253I			Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	253					nucleoside metabolic process	cytoplasm|nucleus				breast(1)|endometrium(7)|kidney(2)|large_intestine(4)|lung(4)	18						AGCTGTAAAGGTTCTTATAGA	0.373000													20	96					0	0	0.624587	0	0
NFASC	23114	broad.mit.edu	37	1	204948496	204948496	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:204948496T>C	ENST00000367172.4	+	19	2313	c.1985T>C	c.(1984-1986)gTc>gCc	p.V662A	NFASC_ENST00000338515.6_Missense_Mutation_p.V662A|NFASC_ENST00000404076.1_Missense_Mutation_p.V641A|NFASC_ENST00000367169.4_Missense_Mutation_p.V662A|NFASC_ENST00000513543.1_Missense_Mutation_p.V658A|NFASC_ENST00000338586.6_Missense_Mutation_p.V662A|NFASC_ENST00000401399.1_Missense_Mutation_p.V662A|NFASC_ENST00000360049.4_Missense_Mutation_p.V658A|NFASC_ENST00000339876.6_Missense_Mutation_p.V662A|NFASC_ENST00000367171.4_Missense_Mutation_p.V647A|NFASC_ENST00000404907.1_Missense_Mutation_p.V658A|NFASC_ENST00000539706.1_Missense_Mutation_p.V658A|NFASC_ENST00000367170.4_Missense_Mutation_p.V662A			O94856	NFASC_HUMAN	neurofascin	662	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCAGACTACGTCGTCCAGTTT	0.512000													66	121					0	0	0.870114	0	0
DET1	55070	broad.mit.edu	37	15	89056277	89056277	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:89056277A>G	ENST00000564406.1	-	6	1751	c.1591T>C	c.(1591-1593)Ttc>Ctc	p.F531L	DET1_ENST00000268148.8_Missense_Mutation_p.F520L|DET1_ENST00000444300.1_Missense_Mutation_p.F531L	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	520						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			TGAAAGGTGAAGGCAACAAGG	0.532000													22	63					0	0	0.608945	0	0
OR10G7	390265	broad.mit.edu	37	11	123909514	123909514	+	Silent	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123909514G>C	ENST00000330487.5	-	1	203	c.195C>G	c.(193-195)tcC>tcG	p.S65S		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGTCAATGAAGGACAGGTTGG	0.552000													6	205					0	0	0.217242	0	0
QSER1	79832	broad.mit.edu	37	11	32975569	32975569	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:32975569A>C	ENST00000399302.2	+	5	4292	c.3957A>C	c.(3955-3957)gaA>gaC	p.E1319D	QSER1_ENST00000527788.1_Missense_Mutation_p.E1080D	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1319										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					AGCCCATTGAACTTGATGGTC	0.448000													33	63					0	0	0.788014	0	0
FAM198B	51313	broad.mit.edu	37	4	159092386	159092386	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:159092386A>G	ENST00000296530.8	-	2	763	c.142T>C	c.(142-144)Ttg>Ctg	p.L48L	FAM198B_ENST00000592057.1_Silent_p.L48L|FAM198B_ENST00000589306.1_Intron|RP11-597D13.9_ENST00000509463.1_RNA|FAM198B_ENST00000393807.5_Silent_p.L48L|FAM198B_ENST00000585682.1_Silent_p.L48L|RP11-597D13.9_ENST00000503611.1_RNA	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	48						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						AGGAAGCCCAAGTAGATGGCA	0.662000													32	22					0	0	0.750413	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465236	70465236	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:70465236T>C	ENST00000373998.1	-	18	3621	c.2924A>G	c.(2923-2925)aAt>aGt	p.N975S	ZMYM3_ENST00000353904.2_Missense_Mutation_p.N987S|ZMYM3_ENST00000373984.3_Missense_Mutation_p.N989S|ZMYM3_ENST00000373988.1_Missense_Mutation_p.N989S|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000314425.5_Missense_Mutation_p.N987S	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	987					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					ATCCAAGACATTGGCCATCTT	0.532000													26	23					0	0	0.788014	0	0
FAM135A	57579	broad.mit.edu	37	6	71162230	71162230	+	Nonsense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:71162230C>G	ENST00000418814.2	+	5	727	c.113C>G	c.(112-114)tCa>tGa	p.S38*	FAM135A_ENST00000505769.1_Nonsense_Mutation_p.S38*|FAM135A_ENST00000505868.1_Nonsense_Mutation_p.S38*|FAM135A_ENST00000361499.3_Nonsense_Mutation_p.S38*|FAM135A_ENST00000370479.3_Intron|FAM135A_ENST00000457062.2_Intron	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	38										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						AAAATTCCATCAAGAATTCCC	0.318000													42	91					0	0	0.870114	0	0
PRDM10	56980	broad.mit.edu	37	11	129794867	129794867	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:129794867A>G	ENST00000358825.5	-	13	2031	c.1800T>C	c.(1798-1800)ctT>ctC	p.L600L	PRDM10_ENST00000423662.2_Silent_p.L514L|PRDM10_ENST00000304538.6_Silent_p.L510L|PRDM10_ENST00000526082.1_Silent_p.L514L|PRDM10_ENST00000528746.1_Silent_p.L570L|PRDM10_ENST00000360871.3_Silent_p.L596L	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	600					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TCAACAAATCAAGGCGGTCAA	0.458000													5	247					0	0	0.184627	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869844	36869844	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:36869844G>A	ENST00000279024.4	-	3	960	c.689C>T	c.(688-690)gCc>gTc	p.A230V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	230										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CAAACTCTGGGCAGGAAGCAC	0.592000													32	72					0	0	0.769981	0	0
XYLT1	64131	broad.mit.edu	37	16	17294474	17294474	+	Silent	SNP	G	G	A	rs145318002		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:17294474G>A	ENST00000261381.6	-	4	1035	c.951C>T	c.(949-951)tcC>tcT	p.S317S		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	317					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGTACTCCACGGAGTCCTCGT	0.577000													80	155					0	0	0.870114	0	0
MED1	5469	broad.mit.edu	37	17	37565271	37565271	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:37565271G>A	ENST00000300651.6	-	17	3426	c.3203C>T	c.(3202-3204)cCt>cTt	p.P1068L	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	1068					androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGTTCCCTTAGGAATCTGAAT	0.512000										HNSCC(31;0.082)			75	167					0	0	0.870114	0	0
TRPM2	7226	broad.mit.edu	37	21	45819196	45819196	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:45819196T>C	ENST00000397928.1	+	14	2525	c.2080T>C	c.(2080-2082)Tac>Cac	p.Y694H	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.Y694H|TRPM2_ENST00000397932.2_Missense_Mutation_p.Y694H|TRPM2_ENST00000300481.9_Missense_Mutation_p.Y674H	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	694						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CACCGAGTGCTACCGGAAGGA	0.642000													3	89					0	0	0.150653	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615829	140615829	+	RNA	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140615829G>A	ENST00000526308.1	+	0	1892					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						CTGCAGAACGGCTCGGCGCCC	0.716000													30	11					0	0	0.812448	0	0
NAMPT	10135	broad.mit.edu	37	7	105904030	105904030	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:105904030T>C	ENST00000222553.3	-	7	1084	c.777A>G	c.(775-777)aaA>aaG	p.K259K	NAMPT_ENST00000354289.4_Silent_p.K259K	NM_005746.2	NP_005737.1	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	259					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						CAAAAGCATCTTTTTCATGGT	0.373000													5	278					0	0	0.248553	0	0
SLC5A11	115584	broad.mit.edu	37	16	24920260	24920260	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:24920260A>T	ENST00000347898.3	+	14	2115	c.1493A>T	c.(1492-1494)gAc>gTc	p.D498V	SLC5A11_ENST00000567758.1_Missense_Mutation_p.D463V|SLC5A11_ENST00000539472.1_Missense_Mutation_p.D434V|SLC5A11_ENST00000568579.1_Missense_Mutation_p.D428V|SLC5A11_ENST00000545376.1_Missense_Mutation_p.D428V|SLC5A11_ENST00000449109.2_Missense_Mutation_p.D342V|SLC5A11_ENST00000565769.1_Missense_Mutation_p.D434V|SLC5A11_ENST00000424767.2_Missense_Mutation_p.D463V|SLC5A11_ENST00000569071.1_Missense_Mutation_p.D342V	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	498					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CTGGTCCTGGACTTTATTTAC	0.567000													33	37					0	0	0.804634	0	0
CPA1	1357	broad.mit.edu	37	7	130024430	130024430	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:130024430C>T	ENST00000011292.3	+	7	900	c.750C>T	c.(748-750)ggC>ggT	p.G250G	CPA1_ENST00000484324.1_Silent_p.G162G	NM_001868.2	NP_001859.1	P15085	CBPA1_HUMAN	carboxypeptidase A1 (pancreatic)	250					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(18;0.0435)					TCTGTATTGGCGTGGACCCCA	0.597000													34	70					0	0	0.788014	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461598	50461598	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:50461598G>A	ENST00000447370.2	-	8	1683	c.1593C>T	c.(1591-1593)cgC>cgT	p.R531R	SIGLEC11_ENST00000426971.2_Intron|CTC-326K19.6_ENST00000451973.1_Silent_p.R17R	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	531					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AGGCCTTACAGCGGAGCCTGA	0.667000													22	43					0	0	0.624587	0	0
BAG1	573	broad.mit.edu	37	9	33264251	33264251	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:33264251G>A	ENST00000472232.3	-	1	508	c.422C>T	c.(421-423)gCa>gTa	p.A141V	BAG1_ENST00000379704.2_Missense_Mutation_p.A26V	NM_001172415.1|NM_004323.5	NP_001165886.1|NP_004314.5	Q99933	BAG1_HUMAN	BCL2-associated athanogene	141					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00506)			GAGCCCAGCTGCCGCCATTTC	0.667000													10	13					0	0	0.387290	0	0
DIS3L2	129563	broad.mit.edu	37	2	233195446	233195446	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:233195446G>T	ENST00000325385.7	+	16	2246	c.1970G>T	c.(1969-1971)cGc>cTc	p.R657L	DIS3L2_ENST00000273009.6_Intron|DIS3L2_ENST00000409307.1_Missense_Mutation_p.R657L	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	657							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TCACTGGCCCGCAAGGAGGTG	0.592000													80	155					5.00163e-47	5.61681e-47	0.870114	1	0
ADAD2	161931	broad.mit.edu	37	16	84230327	84230327	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:84230327T>C	ENST00000268624.3	+	10	1940	c.1847T>C	c.(1846-1848)gTg>gCg	p.V616A	RP11-486L19.2_ENST00000536986.1_RNA|RP11-486L19.2_ENST00000565643.1_RNA|RP11-486L19.2_ENST00000569834.1_RNA|ADAD2_ENST00000315906.5_Missense_Mutation_p.V534A	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	534					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						GCCAGGGCTGTGGGGAAGCCC	0.667000													12	94					0	0	0.435327	0	0
TDRD6	221400	broad.mit.edu	37	6	46656745	46656745	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:46656745G>A	ENST00000544460.1	+	1	1134	c.880G>A	c.(880-882)Ggg>Agg	p.G294R	TDRD6_ENST00000316081.6_Missense_Mutation_p.G294R	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	294					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			CACGGGGACAGGGGATGAGAA	0.632000													10	25					0	0	0.411799	0	0
SPNS2	124976	broad.mit.edu	37	17	4434362	4434362	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:4434362T>C	ENST00000329078.3	+	5	950	c.740T>C	c.(739-741)aTt>aCt	p.I247T		NM_001124758.1	NP_001118230.1	Q8IVW8	SPNS2_HUMAN	spinster homolog 2 (Drosophila)	247					lipid transport|transmembrane transport	integral to membrane				large_intestine(3)|lung(1)|prostate(1)|skin(1)	6						CTGGGCTACATTACTGGCTCC	0.642000													10	13					0	0	0.411799	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863637	64863637	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:64863637A>G	ENST00000313349.3	-	2	666	c.369T>C	c.(367-369)acT>acC	p.T123T		NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	123					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						CCAGGGGCGTAGTGCTTCCGA	0.701000													44	50					0	0	0.847076	0	0
PRPF40B	25766	broad.mit.edu	37	12	50031329	50031329	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:50031329G>T	ENST00000261897.1	+	16	2104	c.1553G>T	c.(1552-1554)aGc>aTc	p.S518I	PRPF40B_ENST00000548825.2_Missense_Mutation_p.S546I|PRPF40B_ENST00000380281.1_Missense_Mutation_p.S524I			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	524	FF 2.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCAGCAGTCAGCACTGATGTC	0.607000											OREG0021797	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	39					4.35082e-09	4.56836e-09	0.592651	1	0
SUCLG2	8801	broad.mit.edu	37	3	67546326	67546326	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:67546326T>C	ENST00000307227.5	-	9	985	c.958A>G	c.(958-960)Att>Gtt	p.I320V	SUCLG2_ENST00000493112.1_Missense_Mutation_p.I320V|SUCLG2_ENST00000492795.1_Missense_Mutation_p.I320V	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	320					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TTAAGGAAAATGATATCACAA	0.443000													30	19					0	0	0.804634	0	0
RAD52	5893	broad.mit.edu	37	12	1036424	1036424	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:1036424A>G	ENST00000358495.3	-	6	492	c.354T>C	c.(352-354)ggT>ggC	p.G118G	RAD52_ENST00000545564.1_Silent_p.G118G|RAD52_ENST00000430095.2_Silent_p.G118G|RAD52_ENST00000539046.1_Silent_p.G41G|RAD52_ENST00000536177.1_Silent_p.G118G	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	118					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			CATGATATGAACCATCCTGGG	0.532000								Homologous recombination					50	294					0	0	0.870114	0	0
EGLN2	112398	broad.mit.edu	37	19	41307235	41307235	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:41307235T>G	ENST00000593726.1	+	1	1786	c.758T>G	c.(757-759)aTt>aGt	p.I253S	EGLN2_ENST00000303961.4_Missense_Mutation_p.I253S|EGLN2_ENST00000406058.2_Missense_Mutation_p.I253S|CTC-490E21.12_ENST00000601627.1_Missense_Mutation_p.L12V|RAB4B-EGLN2_ENST00000594136.1_3'UTR			Q96KS0	EGLN2_HUMAN	egl-9 family hypoxia-inducible factor 2	253					cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	TGTCGAAGCATTGGTGCCCTC	0.657000													22	34					0	0	0.654019	0	0
DIS3L	115752	broad.mit.edu	37	15	66618704	66618704	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:66618704T>C	ENST00000319194.5	+	12	2213		c.e12+2		DIS3L_ENST00000319212.4_Splice_Site|RP11-352G18.2_ENST00000565993.1_RNA	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like						rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding	p.?(1)		breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGATACACGGTATTCCTCTTT	0.458000													33	71					0	0	0.760397	0	0
ASXL2	55252	broad.mit.edu	37	2	25966872	25966872	+	Silent	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:25966872T>G	ENST00000435504.4	-	13	2627	c.2334A>C	c.(2332-2334)ccA>ccC	p.P778P	ASXL2_ENST00000404843.1_Silent_p.P518P|ASXL2_ENST00000272341.4_Silent_p.P518P|ASXL2_ENST00000336112.4_Silent_p.P750P			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	778					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGGAGGCACTGGGGGGGTTT	0.552000													44	98					0	0	0.870114	0	0
MED12L	116931	broad.mit.edu	37	3	150908555	150908555	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:150908555T>C	ENST00000474524.1	+	13	1843	c.1805T>C	c.(1804-1806)cTc>cCc	p.L602P	MED12L_ENST00000273432.4_Missense_Mutation_p.L462P|MED12L_ENST00000309237.4_Missense_Mutation_p.L602P|MED12L_ENST00000422248.2_Missense_Mutation_p.L602P	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	602					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGGTGCTGCTCTTCTGCGAG	0.468000													16	107					0	0	0.500413	0	0
TNC	3371	broad.mit.edu	37	9	117848833	117848833	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:117848833C>A	ENST00000350763.4	-	3	1588	c.1177G>T	c.(1177-1179)Gag>Tag	p.E393*	TNC_ENST00000542877.1_Nonsense_Mutation_p.E393*|TNC_ENST00000341037.4_Nonsense_Mutation_p.E393*|TNC_ENST00000346706.3_Nonsense_Mutation_p.E393*|TNC_ENST00000340094.3_Nonsense_Mutation_p.E393*|TNC_ENST00000345230.3_Nonsense_Mutation_p.E393*|TNC_ENST00000423613.2_Nonsense_Mutation_p.E393*|TNC_ENST00000537320.1_Nonsense_Mutation_p.E393*|TNC_ENST00000535648.1_Nonsense_Mutation_p.E393*	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	393	EGF-like 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCATCACACTCACACCGCCCG	0.577000													21	23					5.35356e-11	5.65659e-11	0.639603	1	0
SEPT7	989	broad.mit.edu	37	7	35930362	35930362	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:35930362T>C	ENST00000494488.2	+	10	915	c.915T>C	c.(913-915)taT>taC	p.Y305Y	SEPT7_ENST00000432293.2_Intron|SEPT7_ENST00000399034.2_Silent_p.Y320Y|SEPT7_ENST00000399035.3_Silent_p.Y318Y|SEPT7_ENST00000435235.1_Silent_p.Y266Y|SEPT7_ENST00000350320.6_Silent_p.Y318Y			Q16181	SEPT7_HUMAN	septin 7	319					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity	p.Y320Y(3)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)	14						CTGTGACTTATAATGGAGTTG	0.323000													3	60					0	0	0.115264	0	0
PAAF1	80227	broad.mit.edu	37	11	73610254	73610254	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:73610254A>G	ENST00000544909.1	+	3	606	c.349A>G	c.(349-351)Atg>Gtg	p.M117V	PAAF1_ENST00000376384.5_Missense_Mutation_p.M99V|PAAF1_ENST00000541951.1_Start_Codon_SNP_p.M1V|PAAF1_ENST00000544552.1_Missense_Mutation_p.M99V|PAAF1_ENST00000536003.1_Missense_Mutation_p.M99V|PAAF1_ENST00000535604.1_Start_Codon_SNP_p.M1V|PAAF1_ENST00000310571.3_Missense_Mutation_p.M116V|PAAF1_ENST00000543079.1_3'UTR			Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	116					interspecies interaction between organisms	proteasome complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					TGACGGGACCATGAAAATCTG	0.433000													22	55					0	0	0.654019	0	0
POLM	27434	broad.mit.edu	37	7	44113413	44113413	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:44113413G>T	ENST00000242248.5	-	9	1384	c.1283C>A	c.(1282-1284)cCt>cAt	p.P428H	POLM_ENST00000335195.6_Missense_Mutation_p.P391H|POLM_ENST00000395831.3_Missense_Mutation_p.P348H	NM_013284.2	NP_037416.1	Q9NP87	DPOLM_HUMAN	polymerase (DNA directed), mu	428					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(3)|skin(2)	22						CAGGGCGAAAGGGAACTGGCT	0.672000								DNA polymerases (catalytic subunits)					28	64					9.04072e-19	9.82432e-19	0.779181	1	0
KIF15	56992	broad.mit.edu	37	3	44844357	44844357	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:44844357A>G	ENST00000326047.4	+	14	1710	c.1561A>G	c.(1561-1563)Agg>Ggg	p.R521G	KIF15_ENST00000425755.1_Missense_Mutation_p.R156G	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	521					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TCATTCCCTCAGGGAGGAGAA	0.383000													75	53					0	0	0.870114	0	0
RREB1	6239	broad.mit.edu	37	6	7230314	7230314	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:7230314A>G	ENST00000379938.2	+	10	2519	c.1982A>G	c.(1981-1983)cAc>cGc	p.H661R	RREB1_ENST00000379933.3_Missense_Mutation_p.H661R|RREB1_ENST00000334984.6_Missense_Mutation_p.H661R|RREB1_ENST00000349384.6_Missense_Mutation_p.H661R	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	661					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TTGCGTGCCCACGTGCGCTCC	0.662000													21	25					0	0	0.639603	0	0
MTUS2	23281	broad.mit.edu	37	13	29599785	29599785	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:29599785C>A	ENST00000431530.3	+	1	1038	c.980C>A	c.(979-981)cCc>cAc	p.P327H		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	317						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TATGTTCCTCCCAGGAGAGTT	0.507000													3	43					0.115264	0.116093	0.115264	1	0
TBC1D23	55773	broad.mit.edu	37	3	100042461	100042461	+	Silent	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:100042461T>A	ENST00000394144.4	+	19	2056	c.2049T>A	c.(2047-2049)acT>acA	p.T683T	TBC1D23_ENST00000475134.1_Silent_p.T546T|TBC1D23_ENST00000344949.5_Silent_p.T668T|TBC1D23_ENST00000486274.1_3'UTR	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	683						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						GGGATGCAACTAAAGCCATAA	0.264000													15	33					0	0	0.608945	0	0
OR10G7	390265	broad.mit.edu	37	11	123909420	123909420	+	Missense_Mutation	SNP	C	C	T	rs147002134	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123909420C>T	ENST00000330487.5	-	1	297	c.289G>A	c.(289-291)Gtg>Atg	p.V97M		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGCTGAGCCACGCAGCTGTGG	0.537000													9	257					0	0	0.387290	0	0
TEK	7010	broad.mit.edu	37	9	27183560	27183560	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:27183560T>C	ENST00000380036.4	+	8	1576	c.1134T>C	c.(1132-1134)ccT>ccC	p.P378P	TEK_ENST00000519097.1_Silent_p.P231P|TEK_ENST00000406359.4_Silent_p.P335P	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	378	Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGCCGCTACCTACTAATGAAG	0.433000													96	111					0	0	0.870114	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22865538	22865538	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:22865538A>G	ENST00000251822.6	+	6	2071	c.1534A>G	c.(1534-1536)Agc>Ggc	p.S512G	RHOBTB2_ENST00000522948.1_Missense_Mutation_p.S519G|RP11-875O11.1_ENST00000502083.2_RNA|RHOBTB2_ENST00000519685.1_Missense_Mutation_p.S534G	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	512	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGGCACCATCAGCGCCCACAA	0.572000													9	126					0	0	0.307466	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7677807	7677807	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:7677807C>A	ENST00000446248.2	+	13	2610	c.2509C>A	c.(2509-2511)Ctg>Atg	p.L837M	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.L810M	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	810	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCTCCCCCACCTGCGCAAGTT	0.721000													3	6					5.9392e-07	6.16678e-07	0.217242	1	0
LAMA1	284217	broad.mit.edu	37	18	6949184	6949184	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:6949184C>A	ENST00000389658.3	-	59	8565	c.8472G>T	c.(8470-8472)gtG>gtT	p.V2824V		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2824	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCCATCTCCCACCACAGTCA	0.483000													29	54					6.50621e-10	6.84864e-10	0.769981	1	0
LRPPRC	10128	broad.mit.edu	37	2	44145522	44145522	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:44145522C>T	ENST00000260665.7	-	28	2969	c.2912G>A	c.(2911-2913)tGg>tAg	p.W971*		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	971					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCTCTTTGCCAGTCACCGTT	0.299000													28	86					0	0	0.729181	0	0
WDHD1	11169	broad.mit.edu	37	14	55411062	55411062	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:55411062A>G	ENST00000360586.3	-	25	3242	c.3177T>C	c.(3175-3177)acT>acC	p.T1059T	WDHD1_ENST00000421192.1_Silent_p.T936T|WDHD1_ENST00000420358.2_Silent_p.T936T|WDHD1_ENST00000359167.4_Silent_p.T577T	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	1059						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						TTCTTTCTTCAGTTGACAATA	0.328000													80	142					0	0	0.870114	0	0
TAAR5	9038	broad.mit.edu	37	6	132910127	132910127	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:132910127A>G	ENST00000258034.2	-	1	750	c.699T>C	c.(697-699)atT>atC	p.I233I		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	233					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		TCAATGTGGTAATCTGCTGAG	0.512000													45	62					0	0	0.847076	0	0
FES	2242	broad.mit.edu	37	15	91428282	91428282	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:91428282T>C	ENST00000328850.3	+	2	149	c.7T>C	c.(7-9)Ttc>Ctc	p.F3L	FES_ENST00000394302.1_Missense_Mutation_p.F3L|FES_ENST00000450438.2_Missense_Mutation_p.F3L|FES_ENST00000414248.2_Missense_Mutation_p.F3L|FES_ENST00000394300.3_Missense_Mutation_p.F3L|FES_ENST00000444422.2_Missense_Mutation_p.F3L	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	3	FCH.|Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CACTATGGGCTTCTCTTCCGA	0.627000													82	202					0	0	0.870114	0	0
BCORL1	63035	broad.mit.edu	37	X	129173135	129173135	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:129173135A>G	ENST00000540052.1	+	9	4540	c.4496A>G	c.(4495-4497)aAt>aGt	p.N1499S	BCORL1_ENST00000359304.2_Missense_Mutation_p.N1369S|BCORL1_ENST00000303743.5_Missense_Mutation_p.N1573S|BCORL1_ENST00000218147.7_Missense_Mutation_p.N1499S	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1499					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GCGGTGGTCAATGACAACCTG	0.572000													52	61					0	0	0.870114	0	0
MFAP4	4239	broad.mit.edu	37	17	19287984	19287984	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:19287984T>C	ENST00000395592.2	-	6	702	c.631A>G	c.(631-633)Acc>Gcc	p.T211A	MFAP4_ENST00000299610.4_Missense_Mutation_p.T187A|MFAP4_ENST00000497081.2_Missense_Mutation_p.T212A	NM_001198695.1	NP_001185624.1	P55083	MFAP4_HUMAN	microfibrillar-associated protein 4	187	Fibrinogen C-terminal.				cell adhesion|signal transduction	microfibril	receptor binding			large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	10	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CGGTCGAAGGTAGAGAACTTC	0.612000													48	109					0	0	0.870114	0	0
ORC1	4998	broad.mit.edu	37	1	52841244	52841244	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:52841244G>A	ENST00000371568.3	-	15	2379	c.2161C>T	c.(2161-2163)Cgg>Tgg	p.R721W	ORC1_ENST00000371566.1_Missense_Mutation_p.R721W	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	721	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TCCAGGCACCGTCGTGCATCT	0.547000													45	30					0	0	0.870114	0	0
SAMD15	161394	broad.mit.edu	37	14	77844713	77844713	+	Silent	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:77844713A>C	ENST00000216471.4	+	1	1238	c.952A>C	c.(952-954)Aga>Cga	p.R318R	SAMD15_ENST00000533095.2_Intron	NM_001010860.1	NP_001010860.1	Q9P1V8	SAM15_HUMAN	sterile alpha motif domain containing 15	318										breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCACAAGCCAAGAAAGTCTAC	0.433000													28	66					0	0	0.827153	0	0
SNAPC5	10302	broad.mit.edu	37	15	66790065	66790065	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:66790065A>G	ENST00000316634.5	-	1	86	c.5T>C	c.(4-6)cTg>cCg	p.L2P	SNAPC5_ENST00000307979.7_Missense_Mutation_p.L2P|SNAPC5_ENST00000566658.1_Missense_Mutation_p.L2P|SNAPC5_ENST00000395589.2_Missense_Mutation_p.L2P|SNAPC5_ENST00000563480.2_Missense_Mutation_p.L2P			O75971	SNPC5_HUMAN	small nuclear RNA activating complex, polypeptide 5, 19kDa	2					transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)	2						AAGCCGGCTCAGCATGTTGCC	0.682000											OREG0023204	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	41					0	0	0.592651	0	0
ZNF366	167465	broad.mit.edu	37	5	71756853	71756853	+	Silent	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:71756853G>T	ENST00000318442.5	-	2	961	c.471C>A	c.(469-471)ccC>ccA	p.P157P		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		ACACGGCGCTGGGCTTAATGG	0.607000													6	215					5.18039e-06	5.35903e-06	0.278610	1	0
MFSD8	256471	broad.mit.edu	37	4	128842707	128842707	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:128842707T>C	ENST00000296468.3	-	12	1449	c.1322A>G	c.(1321-1323)tAt>tGt	p.Y441C	MFSD8_ENST00000515130.1_5'UTR|MFSD8_ENST00000513559.1_Missense_Mutation_p.Y396C	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	441					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						AATTTTTGAATATAGAGTATA	0.408000													52	39					0	0	0.870114	0	0
ZNF750	79755	broad.mit.edu	37	17	80789303	80789303	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:80789303C>T	ENST00000269394.3	-	2	1861	c.1028G>A	c.(1027-1029)cGa>cAa	p.R343Q	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|ZNF750_ENST00000572562.1_5'UTR|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	343						intracellular	zinc ion binding	p.R343L(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTCTGATCTCGGGTGAGGCC	0.532000													66	158					0	0	0.870114	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740509	50740509	+	Nonsense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:50740509G>T	ENST00000008391.3	+	8	1519	c.1291G>T	c.(1291-1293)Gag>Tag	p.E431*		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	431							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TGCCAACTCGGAGAAAGCTCC	0.478000													4	50					0.00909568	0.0092275	0.150653	1	0
PCDHB7	56129	broad.mit.edu	37	5	140554722	140554722	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140554722T>A	ENST00000231137.3	+	1	2480	c.2306T>A	c.(2305-2307)aTc>aAc	p.I769N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		769					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAACCAATTATCCCCAACCTG	0.493000													9	66					0	0	0.557998	0	0
GPR112	139378	broad.mit.edu	37	X	135431755	135431755	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:135431755A>G	ENST00000394143.1	+	6	6181	c.5890A>G	c.(5890-5892)Atc>Gtc	p.I1964V	GPR112_ENST00000412101.1_Missense_Mutation_p.I1759V|GPR112_ENST00000394141.1_Missense_Mutation_p.I1759V|GPR112_ENST00000370652.1_Missense_Mutation_p.I1964V|GPR112_ENST00000287534.4_Missense_Mutation_p.I1901V	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1964					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTTAAGAGCTATCACTTCCAC	0.418000													88	70					0	0	0.870114	0	0
TLN1	7094	broad.mit.edu	37	9	35714321	35714321	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:35714321T>G	ENST00000314888.9	-	24	3388	c.3035A>C	c.(3034-3036)cAg>cCg	p.Q1012P	TLN1_ENST00000540444.1_Missense_Mutation_p.Q1012P	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1012					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGCCTGGTCCTGAATCGTTGG	0.597000													46	23					0	0	0.870114	0	0
TRGV2	6974	broad.mit.edu	37	7	38402622	38402622	+	RNA	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:38402622T>A	ENST00000426402.2	-	0	386																											GTCATAGTACTGAAGACGCTG	0.473000													11	117					0	0	0.667858	0	0
CLIP3	25999	broad.mit.edu	37	19	36509856	36509856	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:36509856C>T	ENST00000360535.4	-	9	1354	c.1127G>A	c.(1126-1128)cGg>cAg	p.R376Q	CLIP3_ENST00000593074.1_Missense_Mutation_p.R376Q|AC002116.7_ENST00000586962.1_RNA	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	376					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCGGGGGGTCCGGGGTGTGGA	0.617000													38	66					0	0	0.819951	0	0
GATAD2A	54815	broad.mit.edu	37	19	19609378	19609378	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:19609378G>A	ENST00000404158.1	+	10	1469	c.1051G>A	c.(1051-1053)Gcg>Acg	p.A351T	GATAD2A_ENST00000360315.3_Missense_Mutation_p.A351T|GATAD2A_ENST00000252577.5_Missense_Mutation_p.A351T|GATAD2A_ENST00000358713.3_Missense_Mutation_p.A351T|GATAD2A_ENST00000537887.1_5'UTR|GATAD2A_ENST00000429563.2_Missense_Mutation_p.A178T			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	351					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						CGCCAAGCTGGCGCTGCGCAA	0.647000													6	12					0	0	0.479597	0	0
USP43	124739	broad.mit.edu	37	17	9631817	9631817	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:9631817T>C	ENST00000570827.2	+	15	3023	c.1949T>C	c.(1948-1950)aTg>aCg	p.M650T	USP43_ENST00000570475.1_Missense_Mutation_p.M956T|USP43_ENST00000285199.6_Missense_Mutation_p.M961T			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	961					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.M962T(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						AGCTTCCAGATGGGAAGCAAA	0.567000													8	26					0	0	0.307466	0	0
BBC3	27113	broad.mit.edu	37	19	47725155	47725155	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:47725155C>T	ENST00000449228.1	-	4	752	c.589G>A	c.(589-591)Gca>Aca	p.A197T	BBC3_ENST00000439096.2_Silent_p.R162R|BBC3_ENST00000341983.4_Silent_p.R100R|BBC3_ENST00000300880.7_Missense_Mutation_p.A37T	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	103					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		AGGGGCGGTGCCGCTGCTGCT	0.612000													4	45					0	0	0.150653	0	0
DLC1	10395	broad.mit.edu	37	8	13356895	13356895	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:13356895G>A	ENST00000276297.4	-	2	1095	c.686C>T	c.(685-687)gCt>gTt	p.A229V	DLC1_ENST00000511869.1_Missense_Mutation_p.A229V|DLC1_ENST00000316609.5_Missense_Mutation_p.A229V	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	229					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						AGCAATTACAGCAGAGTTAAG	0.388000													42	436					0	0	0.819951	0	0
ALX4	60529	broad.mit.edu	37	11	44297022	44297022	+	Missense_Mutation	SNP	C	C	T	rs104894193		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:44297022C>T	ENST00000329255.3	-	2	756	c.653G>A	c.(652-654)cGg>cAg	p.R218Q		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	218			R -> Q (in PFM2).		hair follicle development			p.R218Q(1)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						GAAGGTGGTCCGGTTCCGCCG	0.632000													97	218					0	0	0.870114	0	0
MSGN1	343930	broad.mit.edu	37	2	17998261	17998261	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:17998261G>A	ENST00000281047.3	+	1	499	c.476G>A	c.(475-477)gGc>gAc	p.G159D		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	159	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGCCAGAGAGGCCAGCCTCTC	0.587000													14	20					0	0	0.557998	0	0
DEPDC5	9681	broad.mit.edu	37	22	32188793	32188793	+	Missense_Mutation	SNP	G	G	A	rs12158711		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:32188793G>A	ENST00000400246.1	+	12	899	c.757G>A	c.(757-759)Gac>Aac	p.D253N	DEPDC5_ENST00000536766.1_Missense_Mutation_p.D225N|DEPDC5_ENST00000400248.1_Missense_Mutation_p.D253N|DEPDC5_ENST00000400249.2_Missense_Mutation_p.D253N|DEPDC5_ENST00000400242.3_Missense_Mutation_p.D253N|DEPDC5_ENST00000382105.2_Missense_Mutation_p.D253N|DEPDC5_ENST00000382111.2_Missense_Mutation_p.D253N|DEPDC5_ENST00000266091.3_Missense_Mutation_p.D253N|DEPDC5_ENST00000382112.3_Missense_Mutation_p.D253N|DEPDC5_ENST00000535622.1_Missense_Mutation_p.D253N			O75140	DEPD5_HUMAN	DEP domain containing 5	253					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ATTCTATGAAGACTTTTACAA	0.368000													14	123					0	0	0.479597	0	0
STRN	6801	broad.mit.edu	37	2	37193392	37193392	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:37193392A>G	ENST00000263918.4	-	1	223	c.215T>C	c.(214-216)gTg>gCg	p.V72A	STRN_ENST00000379213.2_Missense_Mutation_p.V60A	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	72					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				CGCCCGCTCCACCTCCCACTG	0.716000													3	4					0	0	0.115264	0	0
ZNF862	643641	broad.mit.edu	37	7	149545507	149545507	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:149545507G>C	ENST00000223210.4	+	4	1170	c.925G>C	c.(925-927)Gaa>Caa	p.E309Q		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						TGATGCAGTAGAATCCTGCAT	0.348000													3	9					0	0	0.115264	0	0
KIF18A	81930	broad.mit.edu	37	11	28116199	28116199	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:28116199T>C	ENST00000263181.6	-	3	764	c.474A>G	c.(472-474)tcA>tcG	p.S158S		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	158	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						CCTCCAGATATGAAACTGCAG	0.323000													7	285					0	0	0.307466	0	0
DHX8	1659	broad.mit.edu	37	17	41582145	41582145	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:41582145G>A	ENST00000262415.3	+	12	1752	c.1680G>A	c.(1678-1680)gaG>gaA	p.E560E	DHX8_ENST00000540306.1_Silent_p.E560E	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	560						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CAATCCTTGAGCAGAGGGAGA	0.463000													69	144					0	0	0.870114	0	0
C20orf194	25943	broad.mit.edu	37	20	3240664	3240664	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:3240664T>C	ENST00000252032.9	-	32	2951	c.2884A>G	c.(2884-2886)Aaa>Gaa	p.K962E	C20orf194_ENST00000453730.2_3'UTR	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	962										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						GCATTCAATTTACCTTCATAC	0.493000													26	53					0	0	0.693898	0	0
C4BPA	722	broad.mit.edu	37	1	207300202	207300202	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:207300202A>G	ENST00000367070.3	+	7	1045	c.851A>G	c.(850-852)gAt>gGt	p.D284G		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	284	Sushi 4.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TGTGATGCTGATAGCAAATGG	0.403000													55	151					0	0	0.870114	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090852	91090852	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:91090852G>T	ENST00000373094.1	+	1	1194	c.349G>T	c.(349-351)Gat>Tat	p.D117Y	PCDH11X_ENST00000361724.1_Missense_Mutation_p.D117Y|PCDH11X_ENST00000406881.1_Missense_Mutation_p.D117Y|PCDH11X_ENST00000373088.1_Missense_Mutation_p.D117Y|PCDH11X_ENST00000373097.1_Missense_Mutation_p.D117Y|PCDH11X_ENST00000395337.2_Missense_Mutation_p.D117Y|PCDH11X_ENST00000361655.2_Missense_Mutation_p.D117Y|PCDH11X_ENST00000504220.1_Missense_Mutation_p.D117Y|PCDH11X_ENST00000298274.8_Missense_Mutation_p.D117Y	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	117	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CATTTTGCCGGATGAAATATT	0.393000													4	167					0.00024832	0.000255311	0.150653	1	0
ERBB3	2065	broad.mit.edu	37	12	56479046	56479046	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:56479046C>T	ENST00000411731.2	+	3	666	c.502C>T	c.(502-504)Ctc>Ttc	p.L168F	ERBB3_ENST00000415288.2_Intron|ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000267101.3_Intron	NM_001005915.1	NP_001005915.1	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	0					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCCAAGACTGCTCACTCTAAG	0.582000													18	30					0	0	0.557998	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554720	140554720	+	Silent	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140554720T>A	ENST00000231137.3	+	1	2478	c.2304T>A	c.(2302-2304)atT>atA	p.I768I		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		768					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAAACCAATTATCCCCAACC	0.488000													10	66					0	0	0.575678	0	0
NVL	4931	broad.mit.edu	37	1	224505589	224505589	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:224505589C>T	ENST00000281701.6	-	3	434	c.175G>A	c.(175-177)Gta>Ata	p.V59I	NVL_ENST00000391875.2_5'UTR|NVL_ENST00000361463.3_5'UTR|NVL_ENST00000482491.1_5'UTR|NVL_ENST00000469075.1_Missense_Mutation_p.V59I|NVL_ENST00000468673.1_5'UTR|NVL_ENST00000340871.4_5'UTR	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	59						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		CCTTTTTCTACCTGAATCCTA	0.294000													19	73					0	0	0.557998	0	0
TMEM97	27346	broad.mit.edu	37	17	26653714	26653714	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:26653714C>T	ENST00000226230.6	+	3	571	c.426C>T	c.(424-426)acC>acT	p.T142T	TMEM97_ENST00000583381.1_Silent_p.T35T|TMEM97_ENST00000336687.6_Silent_p.T35T	NM_014573.2	NP_055388.2	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	142					cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding			endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	6	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		AACGGTTAACCCTTGTGTCTG	0.408000													35	53					0	0	0.804634	0	0
WDR72	256764	broad.mit.edu	37	15	53907852	53907852	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:53907852T>C	ENST00000396328.1	-	15	2790	c.2551A>G	c.(2551-2553)Agt>Ggt	p.S851G	WDR72_ENST00000557913.1_Missense_Mutation_p.S848G|WDR72_ENST00000559418.1_Missense_Mutation_p.S861G|WDR72_ENST00000360509.5_Missense_Mutation_p.S851G	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	851										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		ATCATTCCACTATTGCATAAA	0.353000													64	124					0	0	0.870114	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88207490	88207490	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:88207490C>T	ENST00000357081.3	-	19	2697	c.2553G>A	c.(2551-2553)acG>acA	p.T851T	AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376109.3_Silent_p.T863T|AGTPBP1_ENST00000376083.3_Silent_p.T811T|AGTPBP1_ENST00000432218.1_Intron			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	851					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						AAGTTGAATACGTATATGGAT	0.279000													35	112					0	0	0.804634	0	0
CNN2	1265	broad.mit.edu	37	19	1037669	1037669	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:1037669A>G	ENST00000263097.4	+	7	1063	c.700A>G	c.(700-702)Aag>Gag	p.K234E	CNN2_ENST00000565096.2_Missense_Mutation_p.K223E|CNN2_ENST00000606983.1_3'UTR|CNN2_ENST00000348419.3_Missense_Mutation_p.K195E|CNN2_ENST00000562958.2_Missense_Mutation_p.K255E	NM_004368.2	NP_004359.1	Q99439	CNN2_HUMAN	calponin 2	234					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTATGATACCAAGCTGGGAAC	0.637000													101	87					0	0	0.870114	0	0
CES1	1066	broad.mit.edu	37	16	55857583	55857583	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:55857583T>A	ENST00000422046.2	-	4	696	c.415A>T	c.(415-417)Atc>Ttc	p.I139F	CES1_ENST00000361503.4_Missense_Mutation_p.I139F|CES1_ENST00000566555.1_5'UTR|CES1_ENST00000360526.3_Missense_Mutation_p.I140F			P23141	EST1_HUMAN	carboxylesterase 1	139					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CCTCCGTGGATCCACACCATC	0.557000													7	54					0	0	0.335167	0	0
UNC79	57578	broad.mit.edu	37	14	94088152	94088152	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:94088152C>T	ENST00000553484.1	+	31	4793	c.4639C>T	c.(4639-4641)Cgg>Tgg	p.R1547W	UNC79_ENST00000555664.1_Missense_Mutation_p.R1525W|UNC79_ENST00000393151.2_Missense_Mutation_p.R1525W|UNC79_ENST00000256339.4_Missense_Mutation_p.R1348W			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1525						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GTGCATAGATCGGTGTGACAT	0.453000													115	53					0	0	0.870114	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818582	159818582	+	RNA	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:159818582C>T	ENST00000497452.1	-	0	517																											GGACCGGAAGCGGCGCCGCAC	0.776000													14	3					0	0	0.557998	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143311	91143311	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:91143311T>C	ENST00000371809.3	+	2	321	c.241T>C	c.(241-243)Tta>Cta	p.L81L	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	81							binding			endometrium(2)|large_intestine(3)|lung(8)	13						GGCTGAAGACTTAATTCAGAA	0.463000													58	100					0	0	0.870114	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249701	119249701	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:119249701T>C	ENST00000217999.2	-	1	146	c.72A>G	c.(70-72)acA>acG	p.T24T	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	24					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						CCAGCTGAGGTGTGGGGCTTA	0.587000													38	28					0	0	0.812448	0	0
CHD6	84181	broad.mit.edu	37	20	40081515	40081515	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:40081515T>C	ENST00000373233.3	-	21	3365	c.3188A>G	c.(3187-3189)gAc>gGc	p.D1063G	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1063					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CATGAGCTCGTCTTCCTCAAA	0.527000													40	90					0	0	0.853193	0	0
COL22A1	169044	broad.mit.edu	37	8	139729066	139729066	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:139729066A>G	ENST00000303045.6	-	28	2847		c.e28+1		COL22A1_ENST00000435777.1_Splice_Site|COL22A1_ENST00000341807.4_Splice_Site	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AAACAAACAGACCTTCTCTCC	0.373000										HNSCC(7;0.00092)			15	28					0	0	0.479597	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37442500	37442500	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:37442500A>G	ENST00000374660.1	+	13	1639	c.1539_splice	c.e13-1	p.S514_splice	ANKRD30A_ENST00000361713.1_Splice_Site_p.S514_splice|ANKRD30A_ENST00000602533.1_Splice_Site_p.S514_splice			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	570						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CTTTTAACAGAGTCTCTGTGA	0.284000													39	361					0	0	0.870114	0	0
C11orf24	53838	broad.mit.edu	37	11	68029863	68029863	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:68029863C>T	ENST00000304271.6	-	4	1002	c.600G>A	c.(598-600)gcG>gcA	p.A200A	C11orf24_ENST00000533310.1_Intron	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	200						integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						TTCTTGGCAACGCGCTGCTCT	0.617000													48	102					0	0	0.870114	0	0
ZNF320	162967	broad.mit.edu	37	19	53367325	53367325	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:53367325C>T	ENST00000597909.1	-	6	547	c.311G>A	c.(310-312)gGc>gAc	p.G104D				A2RRD8	ZN320_HUMAN	zinc finger protein 320	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		CACATCACAGCCCTGTATAAA	0.468000													29	70					0	0	0.729181	0	0
NF1	4763	broad.mit.edu	37	17	29556200	29556200	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:29556200G>A	ENST00000358273.4	+	21	2950	c.2567G>A	c.(2566-2568)aGc>aAc	p.S856N	NF1_ENST00000356175.3_Missense_Mutation_p.S856N	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	856					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAGCAGAGAAGCAATTCTGGC	0.507000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			27	66					0	0	0.706142	0	0
FAM131A	131408	broad.mit.edu	37	3	184062584	184062584	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:184062584C>A	ENST00000310585.4	+	3	2198	c.834C>A	c.(832-834)ccC>ccA	p.P278P	FAM131A_ENST00000450976.1_Silent_p.P224P|FAM131A_ENST00000383847.2_Silent_p.P309P|FAM131A_ENST00000453072.1_Silent_p.P224P|FAM131A_ENST00000340957.5_Silent_p.P224P|EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000418281.1_Silent_p.P186P			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	278						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACAACTCGCCCCTCACAGAGT	0.672000													27	94					3.33393e-15	3.56298e-15	0.804634	1	0
RAPH1	65059	broad.mit.edu	37	2	204304389	204304389	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:204304389C>T	ENST00000319170.5	-	14	3823	c.3524G>A	c.(3523-3525)cGa>cAa	p.R1175Q	RAPH1_ENST00000374493.3_Missense_Mutation_p.R1227Q|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1175					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GATGGACTTTCGTTGCAGTGT	0.567000													42	77					0	0	0.859065	0	0
PRDM7	11105	broad.mit.edu	37	16	90142264	90142264	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:90142264C>G	ENST00000449207.2	-	1	74	c.55G>C	c.(55-57)Gag>Cag	p.E19Q	PRDM7_ENST00000407825.1_5'UTR|PRDM7_ENST00000569206.1_Intron	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	19						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGCTTCCGCTCTGTTCTCTCT	0.592000													13	14					0	0	0.500413	0	0
ADCY5	111	broad.mit.edu	37	3	123044258	123044258	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:123044258T>C	ENST00000462833.1	-	8	3211	c.1999A>G	c.(1999-2001)Atc>Gtc	p.I667V	ADCY5_ENST00000309879.5_Missense_Mutation_p.I317V|ADCY5_ENST00000491190.1_Missense_Mutation_p.I300V	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	667					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TTGTGCCCGATGGAGTTGGTT	0.587000													84	182					0	0	0.870114	0	0
TTN	7273	broad.mit.edu	37	2	179604723	179604723	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:179604723C>A	ENST00000589042.1	-	48	13461	c.13237G>T	c.(13237-13239)Ggt>Tgt	p.G4413C	TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G4175C|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Missense_Mutation_p.G4050C|TTN_ENST00000591111.1_Missense_Mutation_p.G4096C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G4242C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4096	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAAAAGACCTGGCTGCTCG	0.473000													47	93					1.38909e-20	1.51735e-20	0.870114	1	0
TUFT1	7286	broad.mit.edu	37	1	151535065	151535065	+	Missense_Mutation	SNP	G	G	A	rs113585307		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151535065G>A	ENST00000368849.3	+	3	202	c.140G>A	c.(139-141)gGc>gAc	p.G47D	TUFT1_ENST00000538902.1_Missense_Mutation_p.G66D|TUFT1_ENST00000353024.3_Intron|TUFT1_ENST00000368848.2_Missense_Mutation_p.G22D|TUFT1_ENST00000392712.3_Missense_Mutation_p.G22D	NM_020127.2	NP_064512.1	Q9NNX1	TUFT1_HUMAN	tuftelin 1	47					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGCCAGGCGGGCAGGAAGACC	0.537000													19	33					0	0	0.539581	0	0
DGKH	160851	broad.mit.edu	37	13	42793830	42793830	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:42793830T>C	ENST00000379274.2	+	28	3363	c.2934T>C	c.(2932-2934)ccT>ccC	p.P978P	DGKH_ENST00000538674.1_Silent_p.P869P|DGKH_ENST00000540693.1_Silent_p.P1114P|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000337343.4_Silent_p.P1114P|DGKH_ENST00000261491.4_Silent_p.P1114P|DGKH_ENST00000536612.1_Silent_p.P978P			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	1114					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AGGAACCTCCTATGGATTGCA	0.368000													25	48					0	0	0.706142	0	0
ATP4A	495	broad.mit.edu	37	19	36047924	36047924	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:36047924A>G	ENST00000262623.3	-	12	1788	c.1760T>C	c.(1759-1761)aTg>aCg	p.M587T		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	587					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TGGAAAGTTCATGGCCTCTAC	0.587000													32	56					0	0	0.750413	0	0
AEBP1	165	broad.mit.edu	37	7	44149825	44149825	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:44149825A>G	ENST00000223357.3	+	11	1585	c.1280A>G	c.(1279-1281)gAc>gGc	p.D427G		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	427	F5/8 type C.|Interaction with MAPK1 and MAPK3 (By similarity).|Required for DNA-binding and interaction with NFKBIA (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						ACTGAGGACGACTACTATGAT	0.627000													15	31					0	0	0.539581	0	0
PHLDB2	90102	broad.mit.edu	37	3	111685552	111685552	+	Splice_Site	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:111685552T>G	ENST00000431670.2	+	14	3579		c.e14+2		PHLDB2_ENST00000495180.1_Splice_Site|PHLDB2_ENST00000412622.1_Splice_Site|PHLDB2_ENST00000393923.3_Splice_Site|PHLDB2_ENST00000481953.1_Splice_Site|PHLDB2_ENST00000393925.3_Splice_Site	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2							cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GAATCCAGGGTAAGCTTCATA	0.493000													77	37					0	0	0.870114	0	0
LEFTY2	7044	broad.mit.edu	37	1	226128690	226128690	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:226128690G>A	ENST00000366820.5	-	1	499	c.151C>T	c.(151-153)Ctg>Ttg	p.L51L	LEFTY2_ENST00000420304.2_Silent_p.L51L	NM_003240.3	NP_003231.2	O00292	LFTY2_HUMAN	left-right determination factor 2	51					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16	Breast(184;0.197)					GGGATGACCAGCTTCTCCATG	0.701000													14	37					0	0	0.435327	0	0
BAI3	577	broad.mit.edu	37	6	69949021	69949021	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:69949021T>A	ENST00000370598.1	+	20	3538	c.2717T>A	c.(2716-2718)aTa>aAa	p.I906K	BAI3_ENST00000238918.8_Missense_Mutation_p.I112K	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	906					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCTAGGTACATACGCTCTGAG	0.363000													117	212					0	0	0.870114	0	0
MYOM1	8736	broad.mit.edu	37	18	3085102	3085102	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:3085102T>G	ENST00000356443.4	-	31	4613	c.4280A>C	c.(4279-4281)gAa>gCa	p.E1427A	MYOM1_ENST00000261606.7_Missense_Mutation_p.E1331A|MYOM1_ENST00000400569.3_Missense_Mutation_p.E1427A	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	1427	Ig-like C2-type 4.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CAGGATAACTTCATAAATCCC	0.438000													9	30					0	0	0.361761	0	0
VNN2	8875	broad.mit.edu	37	6	133073887	133073887	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:133073887T>C	ENST00000326499.6	-	4	663	c.537_splice	c.e4-1	p.Y180_splice	VNN2_ENST00000525270.1_Splice_Site_p.Y127_splice|RP1-55C23.7_ENST00000430895.1_RNA|VNN2_ENST00000525289.1_Intron	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	180	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GTACAGGTGGTACTACAACAA	0.403000													4	210					0	0	0.150653	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397273	51397273	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:51397273C>T	ENST00000327536.5	-	1	200	c.101G>A	c.(100-102)gGc>gAc	p.G34D	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	34										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		ATCCCTTGTGCCTTGGGTCCC	0.527000													80	146					0	0	0.870114	0	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													4	130					0	0	0.248553	0	0
INPP5F	22876	broad.mit.edu	37	10	121571296	121571296	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:121571296A>C	ENST00000361976.2	+	15	1881	c.1715A>C	c.(1714-1716)gAa>gCa	p.E572A		NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	572							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CCAGTGACAGAAGATCTTTAT	0.323000													80	135					0	0	0.870114	0	0
RRP1B	23076	broad.mit.edu	37	21	45107597	45107597	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:45107597G>A	ENST00000340648.4	+	13	1459	c.1342G>A	c.(1342-1344)Gca>Aca	p.A448T		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	448					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		CGAGCCAGGTGCAGAGGCCAC	0.662000													15	34					0	0	0.539581	0	0
PMFBP1	83449	broad.mit.edu	37	16	72184607	72184607	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:72184607T>C	ENST00000537465.1	-	5	694	c.536A>G	c.(535-537)aAc>aGc	p.N179S	PMFBP1_ENST00000237353.10_Missense_Mutation_p.N179S|PMFBP1_ENST00000355636.6_Missense_Mutation_p.N34S			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	179										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CCTGTAGAGGTTTAAGCTCCT	0.527000													7	221					0	0	0.248553	0	0
ITM2C	81618	broad.mit.edu	37	2	231741659	231741659	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:231741659T>G	ENST00000326427.6	+	4	664	c.538T>G	c.(538-540)Tgg>Ggg	p.W180G	ITM2C_ENST00000409704.2_Missense_Mutation_p.W118G|ITM2C_ENST00000492029.1_3'UTR|ITM2C_ENST00000335005.6_Missense_Mutation_p.W133G|ITM2C_ENST00000326407.6_Intron	NM_030926.4	NP_112188.1	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C	180	BRICHOS.				negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding			cervix(2)|lung(1)|ovary(1)|skin(1)	5		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		TCGCAACTTCTGGGAGCTCCT	0.582000													43	120					0	0	0.870114	0	0
TIAM1	7074	broad.mit.edu	37	21	32513436	32513436	+	Splice_Site	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:32513436C>T	ENST00000286827.3	-	23	4245	c.3774_splice	c.e23+1	p.E1258_splice	TIAM1_ENST00000541036.1_Splice_Site_p.E1198_splice	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1258					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.E1258E(2)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GGACCCTCACCTCTTTTTTCT	0.398000													26	71					0	0	0.717897	0	0
TBC1D17	79735	broad.mit.edu	37	19	50391043	50391043	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:50391043G>A	ENST00000221543.5	+	15	1910	c.1611G>A	c.(1609-1611)gaG>gaA	p.E537E	TBC1D17_ENST00000535102.2_Silent_p.E504E	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	537						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TGGACATGGAGAGGGACACCC	0.697000													11	14					0	0	0.479597	0	0
EXOC6	54536	broad.mit.edu	37	10	94733826	94733826	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:94733826C>T	ENST00000371552.4	+	18	1804	c.1775C>T	c.(1774-1776)gCa>gTa	p.A592V	EXOC6_ENST00000260762.6_Missense_Mutation_p.A597V|EXOC6_ENST00000371547.4_Missense_Mutation_p.A613V|EXOC6_ENST00000443748.2_Missense_Mutation_p.A494V	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	597					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				CGACATGCAGCAGAAGGAGAA	0.338000													33	72					0	0	0.779181	0	0
FGA	2243	broad.mit.edu	37	4	155508013	155508013	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:155508013G>A	ENST00000302053.3	-	5	646	c.568C>T	c.(568-570)Cgt>Tgt	p.R190C	FGA_ENST00000403106.3_Missense_Mutation_p.R190C	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	190					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCTACTTCACGAGCTAAAGCC	0.418000													6	110					0	0	0.278610	0	0
SLC5A10	125206	broad.mit.edu	37	17	18916767	18916767	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:18916767G>A	ENST00000317977.6	+	9	1397	c.826G>A	c.(826-828)Ggg>Agg	p.G276R	SLC5A10_ENST00000395645.3_Missense_Mutation_p.G343R|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395647.2_Missense_Mutation_p.G359R|SLC5A10_ENST00000395643.2_Missense_Mutation_p.G316R|SLC5A10_ENST00000395642.1_Missense_Mutation_p.G276R			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	343					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						GCGGGCCTGCGGGGCCGAGGT	0.642000													20	44					0	0	0.717897	0	0
RABEP1	9135	broad.mit.edu	37	17	5280457	5280457	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:5280457T>C	ENST00000262477.6	+	14	2296	c.2072T>C	c.(2071-2073)gTg>gCg	p.V691A	NUP88_ENST00000573169.1_Intron|RABEP1_ENST00000546142.2_Missense_Mutation_p.V691A|RABEP1_ENST00000537505.1_Missense_Mutation_p.V648A|RABEP1_ENST00000408982.2_Missense_Mutation_p.V691A|RABEP1_ENST00000341923.6_Missense_Mutation_p.V691A	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	691					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						ATCATTAATGTGCGGACAGCA	0.398000													112	232					0	0	0.870114	0	0
LPIN3	64900	broad.mit.edu	37	20	39978750	39978750	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:39978750C>T	ENST00000373257.3	+	7	906	c.815C>T	c.(814-816)gCa>gTa	p.A272V		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	272					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				AGAGCTGGGGCAACCTCTCCT	0.627000													5	22					0	0	0.248553	0	0
DCST2	127579	broad.mit.edu	37	1	154997047	154997047	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:154997047A>G	ENST00000368424.3	-	11	1701	c.1643T>C	c.(1642-1644)cTg>cCg	p.L548P	DCST2_ENST00000295536.5_Missense_Mutation_p.L548P	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	548						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCGGCGGCTCAGAAGTACATT	0.612000													12	27					0	0	0.557998	0	0
CD4	920	broad.mit.edu	37	12	6924067	6924067	+	Silent	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:6924067T>A	ENST00000011653.4	+	5	774	c.516T>A	c.(514-516)tcT>tcA	p.S172S	CD4_ENST00000541982.1_Silent_p.S117S|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	172	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TCTCCGTGTCTCAGCTGGAGC	0.542000													19	45					0	0	0.539581	0	0
ANXA6	309	broad.mit.edu	37	5	150519732	150519732	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:150519732T>C	ENST00000354546.5	-	3	318	c.91A>G	c.(91-93)Act>Gct	p.T31A	ANXA6_ENST00000377751.5_Missense_Mutation_p.T31A|ANXA6_ENST00000523714.1_5'UTR|ANXA6_ENST00000356496.5_Missense_Mutation_p.T31A|ANXA6_ENST00000521512.1_Missense_Mutation_p.T31A	NM_001155.4	NP_001146.2	P08133	ANXA6_HUMAN	annexin A6	31						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding			endometrium(2)|kidney(1)|lung(9)	12		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCATGGCAGTGTACAGAGCC	0.577000													7	25					0	0	0.335167	0	0
LNPEP	4012	broad.mit.edu	37	5	96350727	96350727	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:96350727C>A	ENST00000231368.5	+	13	2996	c.2304C>A	c.(2302-2304)gcC>gcA	p.A768A	LNPEP_ENST00000395770.3_Silent_p.A754A	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	768					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TCACCGAAGCCCTGTTTCAGA	0.443000													71	119					1.35869e-18	1.47454e-18	0.870114	1	0
DMWD	1762	broad.mit.edu	37	19	46290079	46290079	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:46290079C>T	ENST00000270223.6	-	3	720	c.675G>A	c.(673-675)tcG>tcA	p.S225S	DMWD_ENST00000377735.3_Silent_p.S225S	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	225					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		ACAGGCTCTCCGACTCAGGCA	0.612000													7	11					0	0	0.335167	0	0
OR10G8	219869	broad.mit.edu	37	11	123900583	123900583	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123900583T>C	ENST00000431524.1	+	1	287	c.254T>C	c.(253-255)tTc>tCc	p.F85S		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		ACTTTGGTGTTCCCAAGTGGC	0.522000													9	97					0	0	0.859065	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19363023	19363023	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:19363023A>G	ENST00000454498.2	-	4	1336	c.323T>C	c.(322-324)cTg>cCg	p.L108P	CSGALNACT1_ENST00000544602.1_Missense_Mutation_p.L108P|CSGALNACT1_ENST00000332246.6_Missense_Mutation_p.L108P|CSGALNACT1_ENST00000522854.1_Missense_Mutation_p.L108P|CSGALNACT1_ENST00000311540.4_Missense_Mutation_p.L108P	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	108					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		GCTCCTGTCCAGACCCAGGCC	0.627000													32	49					0	0	0.779181	0	0
EPHB6	2051	broad.mit.edu	37	7	142561951	142561951	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:142561951C>T	ENST00000392957.2	+	7	1180	c.393C>T	c.(391-393)taC>taT	p.Y131Y	EPHB6_ENST00000442129.1_Silent_p.Y131Y|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	131						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TCACCCTTTACTACCGTCAGG	0.632000													31	45					0	0	0.812448	0	0
KIF1B	23095	broad.mit.edu	37	1	10384065	10384065	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:10384065G>A	ENST00000377086.1	+	25	2684	c.2482G>A	c.(2482-2484)Gaa>Aaa	p.E828K	KIF1B_ENST00000263934.6_Missense_Mutation_p.E782K|KIF1B_ENST00000377081.1_Missense_Mutation_p.E828K			O60333	KIF1B_HUMAN	kinesin family member 1B	828					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GGTAGCAGTAGAAGTCCAGGA	0.423000													6	111					0	0	0.248553	0	0
ZNF98	148198	broad.mit.edu	37	19	22574543	22574543	+	Silent	SNP	A	A	G	rs74169607		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:22574543A>G	ENST00000357774.5	-	4	1615	c.1494T>C	c.(1492-1494)gcT>gcC	p.A498A		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A498A(2)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ACTGGTTAAAAGCTTTGCCAC	0.398000													6	175					0	0	0.248553	0	0
IFNA7	3444	broad.mit.edu	37	9	21201942	21201942	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:21201942G>T	ENST00000239347.3	-	1	262	c.223C>A	c.(223-225)Caa>Aaa	p.Q75K		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	75					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GAGATGGCTTGAGTCTTCTGG	0.483000													89	69					2.37326e-55	2.66873e-55	0.870114	1	0
ADD2	119	broad.mit.edu	37	2	70910816	70910816	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:70910816G>A	ENST00000264436.3	-	10	1476	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S	ADD2_ENST00000430656.1_Silent_p.S360S|ADD2_ENST00000413157.2_Silent_p.S344S|ADD2_ENST00000355733.3_Silent_p.S344S|ADD2_ENST00000407644.2_Silent_p.S344S	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	344					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CCCACTGCACGGAGCCCACCT	0.622000													12	41					0	0	0.411799	0	0
TUBB	203068	broad.mit.edu	37	6	30691481	30691481	+	Silent	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:30691481T>A	ENST00000396389.1	+	4	1181	c.588T>A	c.(586-588)acT>acA	p.T196T	TUBB_ENST00000396384.1_Silent_p.T142T|TUBB_ENST00000330914.3_Silent_p.T142T|XXbac-BPG252P9.9_ENST00000607476.1_RNA|TUBB_ENST00000435534.1_Intron|TUBB_ENST00000327892.8_Silent_p.T214T			P07437	TBB5_HUMAN	tubulin, beta class I	214					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			breast(1)|endometrium(1)|kidney(8)|large_intestine(3)|lung(1)|ovary(1)|urinary_tract(1)	16					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	GCTTCCGCACTCTGAAGCTGA	0.537000													41	91					0	0	0.827153	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77331297	77331297	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:77331297T>C	ENST00000282849.5	-	18	3108	c.2690A>G	c.(2689-2691)aAg>aGg	p.K897R		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	897					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GCAAATGGCCTTTACATTTAT	0.373000													79	151					0	0	0.870114	0	0
ZBED4	9889	broad.mit.edu	37	22	50280639	50280639	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:50280639C>A	ENST00000216268.4	+	2	3806	c.3329C>A	c.(3328-3330)tCc>tAc	p.S1110Y		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	1110						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AAGAAGGCGTCCTGGCCGGGG	0.582000													16	14					4.7546e-09	4.9861e-09	0.500413	1	0
MERTK	10461	broad.mit.edu	37	2	112751965	112751965	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:112751965A>G	ENST00000295408.4	+	9	1691	c.1434A>G	c.(1432-1434)atA>atG	p.I478M	MERTK_ENST00000421804.2_Missense_Mutation_p.I478M|MERTK_ENST00000409780.1_Missense_Mutation_p.I302M			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	478	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CAGTGAAAATATTTATCCCTG	0.527000													56	137					0	0	0.870114	0	0
ATAD2B	54454	broad.mit.edu	37	2	23977158	23977158	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:23977158A>G	ENST00000238789.5	-	27	4569	c.4226T>C	c.(4225-4227)gTg>gCg	p.V1409A	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1409							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTTTATCCACCAACAAATC	0.313000													5	13					0	0	0.217242	0	0
PIGO	84720	broad.mit.edu	37	9	35090187	35090187	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:35090187G>A	ENST00000378617.3	-	9	3339	c.2945C>T	c.(2944-2946)gCc>gTc	p.A982V	PIGO_ENST00000341666.3_Missense_Mutation_p.A982V|PIGO_ENST00000298004.5_Missense_Mutation_p.A565V|PIGO_ENST00000361778.2_Missense_Mutation_p.A565V	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	982					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCTGACTCTGGCATCAGCTTC	0.607000													5	60					0	0	0.184627	0	0
TRMT1	55621	broad.mit.edu	37	19	13220782	13220782	+	Silent	SNP	G	G	A	rs139341662	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:13220782G>A	ENST00000592062.1	-	10	1623	c.1053C>T	c.(1051-1053)tgC>tgT	p.C351C	TRMT1_ENST00000221504.8_Intron|TRMT1_ENST00000357720.4_Silent_p.C351C|TRMT1_ENST00000437766.1_Silent_p.C351C			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	351							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GGAAGGCCCCGCAGCCCACAC	0.642000													24	62					0	0	0.779181	0	0
ATP13A3	79572	broad.mit.edu	37	3	194151926	194151926	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:194151926G>T	ENST00000439040.1	-	23	3242	c.2451C>A	c.(2449-2451)agC>agA	p.S817R	ATP13A3_ENST00000256031.4_Missense_Mutation_p.S817R			Q9H7F0	AT133_HUMAN	ATPase type 13A3	817					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GATCCTCTAAGCTATCATGGA	0.343000													5	276					0.0293803	0.0296985	0.248553	1	0
HDAC9	9734	broad.mit.edu	37	7	18705937	18705937	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:18705937G>A	ENST00000406451.3	+	12	1710	c.1560G>A	c.(1558-1560)gcG>gcA	p.A520A	HDAC9_ENST00000405010.3_Silent_p.A520A|HDAC9_ENST00000456174.2_Silent_p.A492A|HDAC9_ENST00000401921.1_Silent_p.A479A|HDAC9_ENST00000417496.2_Silent_p.A518A|HDAC9_ENST00000524023.1_Silent_p.A443A|HDAC9_ENST00000428307.2_Silent_p.A476A|HDAC9_ENST00000441542.2_Silent_p.A523A|HDAC9_ENST00000406072.1_Silent_p.A507A|HDAC9_ENST00000432645.2_Silent_p.A520A	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	520					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AAGACAGAGCGCCCTCTAGTG	0.542000											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	72					0	0	0.819951	0	0
DMBX1	127343	broad.mit.edu	37	1	46972769	46972769	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:46972769G>A	ENST00000371956.4	+	1	102	c.87G>A	c.(85-87)caG>caA	p.Q29Q	DMBX1_ENST00000360032.3_Silent_p.Q29Q	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	29	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					AGGCAGCCCAGCAGGCCCAGC	0.642000													18	18					0	0	0.539581	0	0
NECAB2	54550	broad.mit.edu	37	16	84031849	84031849	+	Missense_Mutation	SNP	G	G	A	rs147666898		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:84031849G>A	ENST00000565691.1	+	8	1362	c.640G>A	c.(640-642)Gag>Aag	p.E214K	NECAB2_ENST00000567703.1_3'UTR|NECAB2_ENST00000305202.4_Missense_Mutation_p.E297K			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	297					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						CGTGTGCCCCGAGCAACTGAG	0.652000													14	24					0	0	0.500413	0	0
PLB1	151056	broad.mit.edu	37	2	28841245	28841245	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:28841245C>T	ENST00000422425.2	+	45	3305	c.3261C>T	c.(3259-3261)gcC>gcT	p.A1087A	PLB1_ENST00000327757.5_Silent_p.A1098A|PLB1_ENST00000541605.1_Silent_p.A63A	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1098	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					AAGTGGTGGCCGCCCTGGGTG	0.582000													5	75					0	0	0.217242	0	0
F8	2157	broad.mit.edu	37	X	154158320	154158320	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:154158320G>A	ENST00000360256.4	-	14	3945	c.3745C>T	c.(3745-3747)Ctg>Ttg	p.L1249L		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1249	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTAGTGCTCAGTAAGAAAAGG	0.348000													30	82					0	0	0.760397	0	0
FTSJ3	117246	broad.mit.edu	37	17	61898462	61898462	+	Missense_Mutation	SNP	G	G	A	rs145334305		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:61898462G>A	ENST00000427159.2	-	17	2545	c.1900C>T	c.(1900-1902)Cgt>Tgt	p.R634C		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	634					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TTCTTACCACGGAGGGGTTCC	0.532000													32	65					0	0	0.788014	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888081	205888081	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:205888081C>T	ENST00000367135.3	-	19	2256	c.2143G>A	c.(2143-2145)Gtc>Atc	p.V715I	SLC26A9_ENST00000340781.4_Missense_Mutation_p.V715I|SLC26A9_ENST00000367134.2_Missense_Mutation_p.V715I	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	715	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TCCTCAAAGACGCCTCCATGG	0.512000											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	513					0	0	0.278610	0	0
GRM3	2913	broad.mit.edu	37	7	86468878	86468878	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:86468878T>C	ENST00000361669.2	+	4	3147	c.2048T>C	c.(2047-2049)aTc>aCc	p.I683T	GRM3_ENST00000536043.1_Missense_Mutation_p.I555T|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000546348.1_Missense_Mutation_p.I275T	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	683					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAAAATTCATCAGCCCCAGT	0.542000													52	93					0	0	0.870114	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564206	33564206	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:33564206A>G	ENST00000321505.4	+	1	386	c.206A>G	c.(205-207)cAg>cGg	p.Q69R	KIAA1549L_ENST00000389726.3_Missense_Mutation_p.Q69R|KIAA1549L_ENST00000265654.5_Missense_Mutation_p.Q69R					KIAA1549-like																		AGTCTTCTTCAGCTTCCAGAT	0.562000													27	61					0	0	0.769981	0	0
ZNF687	57592	broad.mit.edu	37	1	151259818	151259818	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151259818T>C	ENST00000368879.2	+	2	1149	c.1051T>C	c.(1051-1053)Tca>Cca	p.S351P		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGGTCCCCTCAGATCCTGA	0.557000													26	42					0	0	0.681144	0	0
IGHG4	3503	broad.mit.edu	37	14	106091234	106091234	+	RNA	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:106091234T>C	ENST00000390543.2	-	0	659																											GGGTCCCACCTTTGGCTTTGG	0.622000													106	192					0	0	0.870114	0	0
EXD3	54932	broad.mit.edu	37	9	140243598	140243598	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:140243598G>A	ENST00000340951.4	-	16	1989	c.1794C>T	c.(1792-1794)ggC>ggT	p.G598G	EXD3_ENST00000342129.4_Silent_p.G278G	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	598					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						CTTTCTGCAGGCCGGGTGGCT	0.667000													4	4					0	0	0.248553	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853150	38853150	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:38853150T>C	ENST00000409235.3	+	19	2407	c.2292T>C	c.(2290-2292)acT>acC	p.T764T	CATSPERG_ENST00000410018.1_Silent_p.T724T|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	764					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ACAAGGGCACTGAGTACAGCT	0.627000													23	60					0	0	0.717897	0	0
SEC13	6396	broad.mit.edu	37	3	10346828	10346828	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:10346828G>A	ENST00000397117.1	-	7	1146	c.555C>T	c.(553-555)gaC>gaT	p.D185D	SEC13_ENST00000383801.2_Silent_p.D245D|SEC13_ENST00000350697.3_Silent_p.D199D|SEC13_ENST00000397109.3_Silent_p.D185D|SEC13_ENST00000337354.4_Silent_p.D202D			P55735	SEC13_HUMAN	SEC13 homolog (S. cerevisiae)	199					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17						TCCACTGGCCGTCCTCCTCCT	0.632000													22	12					0	0	0.706142	0	0
SRCIN1	80725	broad.mit.edu	37	17	36705381	36705381	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:36705381G>T	ENST00000264659.7	-	16	3252	c.3028C>A	c.(3028-3030)Cgc>Agc	p.R1010S	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Missense_Mutation_p.R1044S	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	882					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						AAGCTCCGGCGGGGAGGGGGC	0.662000													10	18					5.16669e-11	5.46602e-11	0.387290	1	0
SNAP91	9892	broad.mit.edu	37	6	84302944	84302944	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:84302944C>A	ENST00000428679.2	-	19	2324	c.1731G>T	c.(1729-1731)gcG>gcT	p.A577A	SNAP91_ENST00000369694.2_Silent_p.A577A|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000521485.1_Silent_p.A577A|SNAP91_ENST00000195649.6_Silent_p.A577A|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000439399.2_Silent_p.A577A|SNAP91_ENST00000521743.1_Silent_p.A577A|SNAP91_ENST00000520302.1_Silent_p.A575A			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	577	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CTGGCTTAGGCGCTGCAGCAA	0.413000													3	11					0.217242	0.218282	0.217242	1	0
TNXB	7148	broad.mit.edu	37	6	32015543	32015543	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:32015543C>T	ENST00000375244.3	-	30	10493	c.10292G>A	c.(10291-10293)cGa>cAa	p.R3431Q	TNXB_ENST00000375247.2_Missense_Mutation_p.R3429Q			P22105	TENX_HUMAN	tenascin XB	3476	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGGGCCCAGTCGTTTCCTGCC	0.622000													20	25					0	0	0.608945	0	0
NOC3L	64318	broad.mit.edu	37	10	96116290	96116290	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:96116290A>G	ENST00000371361.3	-	5	666		c.e5+1		NOC3L_ENST00000371350.1_Splice_Site|NOC3L_ENST00000463649.1_Splice_Site	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)							nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				AAGACATATTACCTTCCTCAA	0.284000													108	207					0	0	0.870114	0	0
SOS2	6655	broad.mit.edu	37	14	50666497	50666497	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:50666497A>G	ENST00000216373.5	-	4	696	c.422T>C	c.(421-423)aTt>aCt	p.I141T	SOS2_ENST00000543680.1_Missense_Mutation_p.I141T	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	141					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CAATTTTAAAATATCAGCTGA	0.328000													195	93					0	0	0.870114	0	0
SYVN1	84447	broad.mit.edu	37	11	64898665	64898665	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:64898665C>T	ENST00000526060.1	-	9	954	c.762G>A	c.(760-762)caG>caA	p.Q254Q	SYVN1_ENST00000377190.3_Silent_p.Q254Q|SYVN1_ENST00000307289.6_Silent_p.Q203Q|SYVN1_ENST00000294256.8_Silent_p.Q254Q|SYVN1_ENST00000526121.1_5'UTR			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin	254	Interaction with p53/TP53.				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CTTTCTTGAACTGTCTGAAAG	0.572000													14	26					0	0	0.435327	0	0
PSMD11	5717	broad.mit.edu	37	17	30800953	30800953	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:30800953A>G	ENST00000261712.3	+	7	1041	c.778A>G	c.(778-780)Atg>Gtg	p.M260V	PSMD11_ENST00000457654.2_Missense_Mutation_p.M260V	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	260	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			GTGCAAAATCATGCTCAACAC	0.483000													44	102					0	0	0.853193	0	0
HBE1	3046	broad.mit.edu	37	11	5291119	5291119	+	Translation_Start_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:5291119A>G	ENST00000380237.1	-	3	346	c.2T>C	c.(1-3)aTg>aCg	p.M1T	HBE1_ENST00000292896.2_Start_Codon_SNP_p.M1T|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron			P02100	HBE_HUMAN	hemoglobin, epsilon 1	1					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|skin(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAATGCACCATGATGCCAGG	0.522000													5	44					0	0	0.184627	0	0
SERPINI1	5274	broad.mit.edu	37	3	167508322	167508322	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:167508322A>G	ENST00000295777.5	+	3	844	c.413A>G	c.(412-414)cAt>cGt	p.H138R	SERPINI1_ENST00000446050.2_Missense_Mutation_p.H138R	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	138					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						GCAGTAAATCATGTGGACTTC	0.363000													33	105					0	0	0.750413	0	0
SMARCA4	6597	broad.mit.edu	37	19	11143964	11143964	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:11143964A>G	ENST00000358026.2	+	26	3830		c.e26-1		SMARCA4_ENST00000541122.2_Splice_Site|SMARCA4_ENST00000450717.3_Splice_Site|SMARCA4_ENST00000444061.3_Splice_Site|SMARCA4_ENST00000413806.3_Splice_Site|SMARCA4_ENST00000589677.1_Splice_Site|SMARCA4_ENST00000344626.4_Splice_Site|SMARCA4_ENST00000429416.3_Splice_Site|SMARCA4_ENST00000590574.1_Splice_Site	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4						chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTCTTCCCCCAGGACCTGCAA	0.627000			"""F, N, Mis"""		NSCLC								24	23					0	0	0.681144	0	0
MYO3B	140469	broad.mit.edu	37	2	171092598	171092598	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:171092598C>A	ENST00000334231.6	+	7	728	c.728C>A	c.(727-729)cCt>cAt	p.P243H	MYO3B_ENST00000408978.4_Missense_Mutation_p.P234H|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Missense_Mutation_p.P234H			Q8WXR4	MYO3B_HUMAN	myosin IIIB	234	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GATGGAGACCCTCCCCTCTTT	0.488000											OREG0014376	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	81	151					1.21826e-31	1.35362e-31	0.870114	1	0
IL6R	3570	broad.mit.edu	37	1	154408588	154408588	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:154408588T>C	ENST00000368485.3	+	6	1386		c.e6+2		IL6R_ENST00000344086.4_Splice_Site|IL6R_ENST00000507256.1_Intron	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor						acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTTGGACAGGTACTGCGGTGG	0.587000													3	33					0	0	0.115264	0	0
MRC1	4360	broad.mit.edu	37	10	18122710	18122710	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:18122710G>A	ENST00000239761.3	+	4	823	c.720G>A	c.(718-720)tgG>tgA	p.W240*		NM_002438.2	NP_002429.1	P22897	MRC1_HUMAN	mannose receptor, C type 1	240	C-type lectin 1.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity			breast(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	6						CTTTAACGTGGCACCAAGCGA	0.463000													5	270					0	0	0.184627	0	0
CCT8	10694	broad.mit.edu	37	21	30439048	30439048	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:30439048A>G	ENST00000286788.4	-	6	819	c.613T>C	c.(613-615)Tgt>Cgt	p.C205R	CCT8_ENST00000540844.1_Missense_Mutation_p.C132R|CCT8_ENST00000542732.1_Missense_Mutation_p.C186R|CCT8_ENST00000470450.1_5'UTR	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	205					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						AGAATTTTACAAACTCTGATG	0.289000													47	64					0	0	0.870114	0	0
GRK6	2870	broad.mit.edu	37	5	176868029	176868029	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:176868029T>C	ENST00000355472.5	+	15	1820	c.1652T>C	c.(1651-1653)cTg>cCg	p.L551P	PRR7-AS1_ENST00000425316.3_RNA|GRK6_ENST00000393576.3_Missense_Mutation_p.L517P|GRK6_ENST00000355958.5_Missense_Mutation_p.L551P|GRK6_ENST00000528793.1_Missense_Mutation_p.L551P	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	551					regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAAAGGGACTGCTGCAGAGA	0.627000													6	19					0	0	0.307466	0	0
CORO1B	57175	broad.mit.edu	37	11	67207642	67207642	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:67207642A>G	ENST00000393893.1	-	9	1057	c.954T>C	c.(952-954)ggT>ggC	p.G318G	CORO1B_ENST00000341356.5_Silent_p.G318G|CORO1B_ENST00000539724.1_5'UTR	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	318					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			TGCTGCCCATACCCCGCTGCG	0.612000													34	60					0	0	0.804634	0	0
NFATC1	4772	broad.mit.edu	37	18	77193724	77193724	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:77193724C>A	ENST00000253506.5	+	3	1741	c.1372C>A	c.(1372-1374)Cac>Aac	p.H458N	NFATC1_ENST00000586434.1_Missense_Mutation_p.H445N|NFATC1_ENST00000329101.4_Missense_Mutation_p.H445N|NFATC1_ENST00000545796.1_5'UTR|NFATC1_ENST00000542384.1_Missense_Mutation_p.H458N|NFATC1_ENST00000427363.2_Missense_Mutation_p.H458N|NFATC1_ENST00000397790.2_5'UTR|NFATC1_ENST00000587635.1_Missense_Mutation_p.H458N|NFATC1_ENST00000318065.5_Missense_Mutation_p.H445N|NFATC1_ENST00000592223.1_Missense_Mutation_p.H445N|NFATC1_ENST00000591814.1_Missense_Mutation_p.H458N	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	458	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGCCGGAGGACACCCCATCGT	0.612000													27	45					4.3181e-19	4.70454e-19	0.769981	1	0
SERPIND1	3053	broad.mit.edu	37	22	21140426	21140426	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:21140426C>T	ENST00000215727.5	+	4	1581	c.1298C>T	c.(1297-1299)gCc>gTc	p.A433V	SERPIND1_ENST00000406799.1_Missense_Mutation_p.A433V|PI4KA_ENST00000572273.1_Intron|PI4KA_ENST00000466162.1_Intron|PI4KA_ENST00000255882.6_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	433					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CAAAGGATCGCCATCGACCTG	0.567000													60	70					0	0	0.870114	0	0
NR3C2	4306	broad.mit.edu	37	4	149075708	149075708	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:149075708G>A	ENST00000355292.3	-	5	2733	c.2371C>T	c.(2371-2373)Ctt>Ttt	p.L791F	NR3C2_ENST00000512865.1_Intron|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000511528.1_Missense_Mutation_p.L791F|NR3C2_ENST00000344721.4_Missense_Mutation_p.L787F|NR3C2_ENST00000358102.3_Missense_Mutation_p.L787F|NR3C2_ENST00000342437.4_Intron|RP11-76G10.1_ENST00000514843.1_RNA			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	787	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CTACCTGGAAGTACCTTTGCC	0.507000													4	132					0	0	0.150653	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124633	26124633	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:26124633A>G	ENST00000602637.1	+	1	203	c.173A>G	c.(172-174)tAc>tGc	p.Y58C	HIST1H2AC_ENST00000377791.2_Missense_Mutation_p.Y58C			Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	58					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(5)	12						GTGTTAGAGTACCTGACCGCC	0.667000													11	29					0	0	0.500413	0	0
GALNT15	117248	broad.mit.edu	37	3	16216674	16216674	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:16216674C>T	ENST00000339732.5	+	1	519	c.16C>T	c.(16-18)Cga>Tga	p.R6*	GALNT15_ENST00000437509.1_Nonsense_Mutation_p.R6*	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		CCTAAGGAAGCGATACAGGCA	0.542000													26	22					0	0	0.717897	0	0
RBM6	10180	broad.mit.edu	37	3	50005783	50005783	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:50005783A>T	ENST00000443081.1	+	3	1448	c.529A>T	c.(529-531)Aat>Tat	p.N177Y	RBM6_ENST00000539992.1_Intron|RBM6_ENST00000266022.4_Missense_Mutation_p.N309Y|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000422955.1_Intron			P78332	RBM6_HUMAN	RNA binding motif protein 6	309					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TTCTGGTATGAATGTGAACAG	0.408000													5	90					0	0	0.217242	0	0
DOPEY2	9980	broad.mit.edu	37	21	37591690	37591690	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:37591690T>C	ENST00000399151.3	+	10	1235	c.1150T>C	c.(1150-1152)Ttg>Ctg	p.L384L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	384					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GGTTGGGAATTTGTTTCTCGA	0.403000													174	318					0	0	0.870114	0	0
WTAP	9589	broad.mit.edu	37	6	160164822	160164822	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:160164822A>G	ENST00000358372.4	+	5	2028	c.271A>G	c.(271-273)Act>Gct	p.T91A	WTAP_ENST00000337387.4_Missense_Mutation_p.T91A|SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	91					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GCAAGAGTGTACTGTAAGTAT	0.338000													22	49					0	0	0.654019	0	0
MRPL32	64983	broad.mit.edu	37	7	42977150	42977150	+	Missense_Mutation	SNP	G	G	A	rs146917176		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:42977150G>A	ENST00000223324.2	+	3	729	c.542G>A	c.(541-543)cGa>cAa	p.R181Q	MRPL32_ENST00000496564.1_Intron	NM_031903.2	NP_114109.1	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32	181					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)	10						GACAGAAAGCGACCATCCTGG	0.443000													31	43					0	0	0.760397	0	0
PLEC	5339	broad.mit.edu	37	8	144992015	144992015	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:144992015G>A	ENST00000322810.4	-	32	12554	c.12385C>T	c.(12385-12387)Cgt>Tgt	p.R4129C	PLEC_ENST00000527096.1_Missense_Mutation_p.R4015C|PLEC_ENST00000436759.2_Missense_Mutation_p.R4019C|PLEC_ENST00000357649.2_Missense_Mutation_p.R3996C|PLEC_ENST00000354589.3_Missense_Mutation_p.R3992C|PLEC_ENST00000345136.3_Missense_Mutation_p.R3992C|PLEC_ENST00000356346.3_Missense_Mutation_p.R3978C|PLEC_ENST00000354958.2_Missense_Mutation_p.R3970C|PLEC_ENST00000398774.2_Missense_Mutation_p.R3960C	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4129	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ATGCCCATACGCACAGCCTCC	0.647000													15	31					0	0	0.520397	0	0
UBAP2L	9898	broad.mit.edu	37	1	154227752	154227752	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:154227752C>T	ENST00000428931.1	+	17	2201	c.2034C>T	c.(2032-2034)ggC>ggT	p.G678G	UBAP2L_ENST00000271877.7_Silent_p.G689G|UBAP2L_ENST00000361546.2_Silent_p.G678G|UBAP2L_ENST00000343815.6_Silent_p.G678G	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	678					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCTTGGGTGGCTTGAGCCACA	0.493000													40	191					0	0	0.840704	0	0
RBM12B	389677	broad.mit.edu	37	8	94745931	94745931	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:94745931A>G	ENST00000399300.2	-	3	2921	c.2708T>C	c.(2707-2709)aTg>aCg	p.M903T	RP11-10N23.4_ENST00000517998.1_RNA|RBM12B_ENST00000520961.1_Intron|RBM12B_ENST00000517700.1_Missense_Mutation_p.M783T	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	903							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AAAACTTCCCATATTATGCTT	0.398000													161	272					0	0	0.870114	0	0
RPTOR	57521	broad.mit.edu	37	17	78704364	78704364	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:78704364A>C	ENST00000306801.3	+	5	874	c.512A>C	c.(511-513)tAc>tCc	p.Y171S	RPTOR_ENST00000537330.1_5'UTR|RPTOR_ENST00000544334.2_Missense_Mutation_p.Y171S|RPTOR_ENST00000570891.1_Missense_Mutation_p.Y171S	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	171					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						TTCTAGAACTACACGCAGTAC	0.512000													35	82					0	0	0.796494	0	0
RAB1A	5861	broad.mit.edu	37	2	65316203	65316203	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:65316203T>C	ENST00000409784.3	-	5	480	c.288_splice	c.e5-1	p.E97_splice	RAB1A_ENST00000409751.1_Splice_Site_p.E65_splice|RAB1A_ENST00000494188.1_Intron|RAB1A_ENST00000260638.8_Intron|RAB1A_ENST00000398529.3_Intron|RAB1A_ENST00000409892.1_Splice_Site_p.E33_splice|RAB1A_ENST00000356214.7_Splice_Site_p.E65_splice	NM_004161.4	NP_004152.1	P62820	RAB1A_HUMAN	RAB1A, member RAS oncogene family	97					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)	6						ATTGAAGGACTCCTAAAAAGA	0.353000													8	33					0	0	0.335167	0	0
AP1G1	164	broad.mit.edu	37	16	71767002	71767002	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:71767002G>T	ENST00000299980.4	-	23	2869	c.2428C>A	c.(2428-2430)Cta>Ata	p.L810I	AP1G1_ENST00000569748.1_Missense_Mutation_p.L810I|AP1G1_ENST00000564155.1_Missense_Mutation_p.L235I|AP1G1_ENST00000423132.2_Missense_Mutation_p.L813I|AP1G1_ENST00000393512.3_Missense_Mutation_p.L813I|AP1G1_ENST00000433195.2_Missense_Mutation_p.L833I	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	810	GAE.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				ACCTCTGCTAGATCTTGCATT	0.438000													32	65					6.19805e-25	6.8057e-25	0.812448	1	0
NIPAL2	79815	broad.mit.edu	37	8	99217418	99217418	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:99217418T>C	ENST00000341166.3	-	7	967	c.712A>G	c.(712-714)Atg>Gtg	p.M238V	NIPAL2_ENST00000430223.2_Missense_Mutation_p.M238V|NIPAL2_ENST00000520545.1_5'UTR	NM_024759.1	NP_079035.1	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	238						integral to membrane				cervix(3)|kidney(1)|large_intestine(2)|lung(5)|stomach(1)	12						ATTTTATCCATCACAGAAAAA	0.333000													34	62					0	0	0.760397	0	0
CASS4	57091	broad.mit.edu	37	20	55027381	55027381	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:55027381G>A	ENST00000371336.3	+	5	1350	c.1149G>A	c.(1147-1149)tgG>tgA	p.W383*	CASS4_ENST00000360314.3_Nonsense_Mutation_p.W383*|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	383	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						ATTCCTCATGGTTCTCCAGAC	0.522000													22	48					0	0	0.706142	0	0
NR6A1	2649	broad.mit.edu	37	9	127298227	127298227	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:127298227T>C	ENST00000487099.2	-	7	1166	c.1009A>G	c.(1009-1011)Agc>Ggc	p.S337G	NR6A1_ENST00000344523.4_Missense_Mutation_p.S336G|NR6A1_ENST00000373584.3_Missense_Mutation_p.S333G|NR6A1_ENST00000416460.2_Missense_Mutation_p.S332G	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	337					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						ATCTGCTTGCTGTAAACGGTG	0.532000													13	114					0	0	0.457914	0	0
ATP1B4	23439	broad.mit.edu	37	X	119509328	119509328	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:119509328T>G	ENST00000218008.3	+	5	721	c.664T>G	c.(664-666)Ttt>Gtt	p.F222V	ATP1B4_ENST00000539306.1_Missense_Mutation_p.F179V|ATP1B4_ENST00000361319.3_Missense_Mutation_p.F218V	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	222					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						GGCCTGCCAATTTAAGCGCTC	0.468000													118	100					0	0	0.870114	0	0
CDK12	51755	broad.mit.edu	37	17	37619372	37619372	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:37619372T>C	ENST00000447079.4	+	1	1079		c.e1+2		CDK12_ENST00000430627.2_Splice_Site	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12						mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						ACTCCCCAGGTGAGCTATTTG	0.552000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			26	60					0	0	0.681144	0	0
KMT2C	58508	broad.mit.edu	37	7	151859636	151859636	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:151859636G>C	ENST00000355193.2	-	43	11244	c.11026C>G	c.(11026-11028)Cta>Gta	p.L3676V	KMT2C_ENST00000262189.6_Missense_Mutation_p.L3676V					lysine (K)-specific methyltransferase 2C																		TCTGTACATAGCTGGCCTGCT	0.488000													94	139					0	0	0.870114	0	0
ENOSF1	55556	broad.mit.edu	37	18	697349	697349	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:697349C>T	ENST00000251101.7	-	3	288	c.200G>A	c.(199-201)tGt>tAt	p.C67Y	ENOSF1_ENST00000539164.1_Missense_Mutation_p.C67Y|ENOSF1_ENST00000340116.7_Missense_Mutation_p.C88Y|ENOSF1_ENST00000383578.3_Intron|ENOSF1_ENST00000580982.1_Intron	NM_017512.5	NP_059982.2	Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	67					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						ATTCACAGCACAGACAACTAT	0.418000													123	187					0	0	0.870114	0	0
CYFIP1	23191	broad.mit.edu	37	15	22955133	22955133	+	Splice_Site	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:22955133T>C	ENST00000313077.7	+	15	1652	c.1526_splice	c.e15-1	p.S509_splice	CYFIP1_ENST00000560848.1_Splice_Site_p.S509_splice	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	509					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGGTGTTCAGTGTCCTGCAGG	0.602000													10	88					0	0	0.335167	0	0
MYH7B	57644	broad.mit.edu	37	20	33565798	33565798	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:33565798G>A	ENST00000262873.7	+	3	208	c.116G>A	c.(115-117)aGt>aAt	p.S39N		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	0						membrane|myosin filament	actin binding|ATP binding|motor activity	p.S39N(1)		NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTTCACCCCAGTGCCACTGCC	0.602000													6	197					0	0	0.278610	0	0
MAP3K3	4215	broad.mit.edu	37	17	61766161	61766161	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:61766161A>G	ENST00000361357.3	+	11	1202	c.884A>G	c.(883-885)cAg>cGg	p.Q295R	MAP3K3_ENST00000584573.1_Missense_Mutation_p.Q291R|MAP3K3_ENST00000577784.1_3'UTR|MAP3K3_ENST00000579585.1_Missense_Mutation_p.Q295R|MAP3K3_ENST00000577395.1_Missense_Mutation_p.Q260R|MAP3K3_ENST00000361733.3_Missense_Mutation_p.Q264R	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	264					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						CGGGAAACTCAGCTTTATGAC	0.537000													53	110					0	0	0.870114	0	0
DNAJB2	3300	broad.mit.edu	37	2	220149689	220149689	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:220149689T>C	ENST00000336576.5	+	9	1243	c.955T>C	c.(955-957)Tct>Cct	p.S319P	DNAJB2_ENST00000392086.4_Intron	NM_006736.5	NP_006727.2	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	319					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGAAGGCCTCTCGCTGCCT	0.617000													7	9					0	0	0.335167	0	0
FOXO3	2309	broad.mit.edu	37	6	108985226	108985226	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:108985226C>T	ENST00000406360.1	+	2	1533	c.1190C>T	c.(1189-1191)cCg>cTg	p.P397L	FOXO3_ENST00000343882.6_Missense_Mutation_p.P397L|FOXO3_ENST00000540898.1_Missense_Mutation_p.P177L	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	397					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		ATCACGCTCCCGCCATCCCAG	0.592000													31	54					0	0	0.769981	0	0
ZNF217	7764	broad.mit.edu	37	20	52193033	52193033	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:52193033G>A	ENST00000371471.2	-	4	2695	c.2270C>T	c.(2269-2271)cCg>cTg	p.P757L	ZNF217_ENST00000302342.3_Missense_Mutation_p.P757L			O75362	ZN217_HUMAN	zinc finger protein 217	757					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CAACGCTGGCGGGCATCCGGT	0.502000													39	54					0	0	0.853193	0	0
TBL3	10607	broad.mit.edu	37	16	2026055	2026055	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:2026055A>G	ENST00000568546.1	+	12	1257		c.e12-1			NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3						G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						ACAACATCTCAGATATCGTCC	0.642000													10	207					0	0	0.335167	0	0
DPAGT1	1798	broad.mit.edu	37	11	118971120	118971120	+	Splice_Site	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:118971120T>G	ENST00000409993.2	-	6	2048		c.e6-2		DPAGT1_ENST00000354202.4_Splice_Site|DPAGT1_ENST00000432443.2_Splice_Site			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)						dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		ACAGGATTCCTGCGGGGAGAG	0.493000											OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	87					0	0	0.870114	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232650521	232650521	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:232650521G>A	ENST00000366630.1	-	2	923	c.565C>T	c.(565-567)Cac>Tac	p.H189Y	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.H189Y			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	189					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TACTCCCTGTGCAGGGCAGCC	0.463000													92	173					0	0	0.870114	0	0
KNTC1	9735	broad.mit.edu	37	12	123087702	123087702	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:123087702G>A	ENST00000333479.7	+	48	5190	c.5013G>A	c.(5011-5013)acG>acA	p.T1671T	KNTC1_ENST00000537348.1_Silent_p.T96T|KNTC1_ENST00000436959.3_5'UTR|KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1671					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTAAGATCACGCAGACCATCG	0.433000													4	34					0	0	0.184627	0	0
PRPF8	10594	broad.mit.edu	37	17	1557299	1557299	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:1557299G>A	ENST00000572621.1	-	37	6264	c.5999C>T	c.(5998-6000)gCa>gTa	p.A2000V	PRPF8_ENST00000304992.6_Missense_Mutation_p.A2000V			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	2000	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTCAGTGATGCCACGTTCAC	0.522000													86	218					0	0	0.870114	0	0
ZNF318	24149	broad.mit.edu	37	6	43306339	43306339	+	Silent	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:43306339G>C	ENST00000361428.2	-	10	5474	c.5397C>G	c.(5395-5397)acC>acG	p.T1799T	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1799					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GTCCAATGCTGGTACTTACTC	0.418000													45	97					0	0	0.864702	0	0
FAM78B	149297	broad.mit.edu	37	1	166135352	166135352	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:166135352T>A	ENST00000338353.3	-	2	723	c.134A>T	c.(133-135)aAg>aTg	p.K45M	FAM78B_ENST00000354422.3_Missense_Mutation_p.K45M			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	45										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GTAGGGGGTCTTGTAGCGCAG	0.652000													12	6					0	0	0.387290	0	0
MYH14	79784	broad.mit.edu	37	19	50774688	50774688	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:50774688C>T	ENST00000440075.2	+	25	3103	c.3056C>T	c.(3055-3057)gCt>gTt	p.A1019V	MYH14_ENST00000376970.2_Missense_Mutation_p.A1011V|MYH14_ENST00000262269.8_Missense_Mutation_p.A1019V|MYH14_ENST00000425460.1_Missense_Mutation_p.A986V|MYH14_ENST00000598205.1_Missense_Mutation_p.A986V|MYH14_ENST00000596571.1_Missense_Mutation_p.A978V|MYH14_ENST00000601313.1_Missense_Mutation_p.A1019V			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	978					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CACCTTGAGGCTGAGGAGGGT	0.572000													5	10					0	0	0.217242	0	0
ESPN	83715	broad.mit.edu	37	1	6501114	6501114	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:6501114G>A	ENST00000377828.1	+	5	1147	c.979G>A	c.(979-981)Gtg>Atg	p.V327M		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	327					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGCGCACGGTGGAGAACCT	0.652000													4	2					0	0	0.184627	0	0
GNAO1	2775	broad.mit.edu	37	16	56377829	56377829	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:56377829C>T	ENST00000262494.7	+	8	1292	c.1032C>T	c.(1030-1032)atC>atT	p.I344I	GNAO1_ENST00000262493.6_Intron	NM_138736.2	NP_620073.2	P09471	GNAO_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	344					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)	17		all_neural(199;0.159)				ACGTCATCATCGCCAAAAACC	0.622000													20	44					0	0	0.654019	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584306	138584306	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:138584306C>T	ENST00000251691.4	+	12	1852	c.1686C>T	c.(1684-1686)gtC>gtT	p.V562V		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	562					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGCCAGATGTCGTGCAGAGAA	0.512000													5	40					0	0	0.217242	0	0
LAMB1	3912	broad.mit.edu	37	7	107576084	107576084	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:107576084T>C	ENST00000393561.1	-	25	4220	c.4036A>G	c.(4036-4038)Acc>Gcc	p.T1346A	LAMB1_ENST00000222399.6_Missense_Mutation_p.T1322A|LAMB1_ENST00000474380.1_5'UTR			P07942	LAMB1_HUMAN	laminin, beta 1	1322	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAATACTTGGTAATGCTATCC	0.493000													89	148					0	0	0.870114	0	0
HOXA9	3205	broad.mit.edu	37	7	27203284	27203284	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:27203284A>G	ENST00000343483.6	-	2	829	c.757T>C	c.(757-759)Tgg>Cgg	p.W253R	RP1-170O19.20_ENST00000465941.1_5'UTR|RP1-170O19.20_ENST00000470747.4_Missense_Mutation_p.W93R|HOXA9_ENST00000497089.1_5'UTR|HOXA9_ENST00000396345.1_3'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	253							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						TTCTGGAACCAGATCTTGACC	0.478000			T	"""NUP98, MSI2"""	AML*								41	90					0	0	0.870114	0	0
RBM11	54033	broad.mit.edu	37	21	15599295	15599295	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:15599295A>G	ENST00000400577.3	+	5	536	c.527A>G	c.(526-528)cAt>cGt	p.H176R	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	176							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		TCACTGAATCATGTTCCAGAT	0.453000													13	465					0	0	0.500413	0	0
PDXDC1	23042	broad.mit.edu	37	16	15126717	15126717	+	Splice_Site	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:15126717G>T	ENST00000396410.4	+	18	1668		c.e18-1		PDXDC1_ENST00000569715.1_Splice_Site|PDXDC1_ENST00000563679.1_Splice_Site|PDXDC1_ENST00000325823.7_Splice_Site|PDXDC1_ENST00000450288.2_Splice_Site|PDXDC1_ENST00000447912.2_Splice_Site|PDXDC1_ENST00000535621.2_Intron	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1						carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TGTTGTTTTAGGTATGAACAT	0.373000													134	204					8.90655e-82	1.00829e-81	0.870114	1	0
ACVR1	90	broad.mit.edu	37	2	158630598	158630598	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:158630598A>G	ENST00000263640.3	-	6	1073		c.e6+1		ACVR1_ENST00000410057.2_Splice_Site|ACVR1_ENST00000434821.1_Splice_Site|ACVR1_ENST00000409283.2_Splice_Site	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I						BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	AAAAAGAATTACCGACACACT	0.373000													39	78					0	0	0.796494	0	0
CCDC36	339834	broad.mit.edu	37	3	49293670	49293670	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:49293670A>C	ENST00000438782.1	+	8	976	c.740A>C	c.(739-741)cAg>cCg	p.Q247P	CCDC36_ENST00000452691.2_Missense_Mutation_p.Q247P|CCDC36_ENST00000296449.5_Missense_Mutation_p.Q247P			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	247										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CAGCTAGGCCAGCTGAATGTG	0.507000													6	88					0	0	0.307466	0	0
PHLPP1	23239	broad.mit.edu	37	18	60612366	60612366	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:60612366T>C	ENST00000400316.4	+	12	3431	c.1650T>C	c.(1648-1650)ctT>ctC	p.L550L	PHLPP1_ENST00000262719.5_Silent_p.L1062L	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1062	PH.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TGGAGGAACTTGAAGAAATTG	0.373000													17	35					0	0	0.500413	0	0
DIS3	22894	broad.mit.edu	37	13	73340159	73340159	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:73340159T>C	ENST00000377767.4	-	15	2021	c.1921A>G	c.(1921-1923)Atg>Gtg	p.M641V	DIS3_ENST00000545453.1_Missense_Mutation_p.M479V|DIS3_ENST00000377780.4_Missense_Mutation_p.M611V	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	641					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCACTGTCCATGTGGAATCGA	0.323000										Multiple Myeloma(4;0.011)			19	59					0	0	0.575678	0	0
P4HA1	5033	broad.mit.edu	37	10	74834565	74834565	+	Splice_Site	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:74834565C>G	ENST00000412021.2	-	3	410		c.e3+1		P4HA1_ENST00000394890.2_Splice_Site|P4HA1_ENST00000440381.1_Splice_Site|P4HA1_ENST00000373008.2_Splice_Site|P4HA1_ENST00000307116.2_Splice_Site|P4HA1_ENST00000263556.3_Splice_Site	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I							endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GTAAGACTTACCAATTGAAGT	0.299000													35	77					0	0	0.827153	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421090	105421090	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:105421090A>G	ENST00000333244.5	-	7	817	c.698T>C	c.(697-699)cTg>cCg	p.L233P		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	233						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATCTCCTTCCAGAGTTTTCGT	0.562000													15	27					0	0	0.500413	0	0
SPTB	6710	broad.mit.edu	37	14	65240097	65240097	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:65240097T>C	ENST00000389722.3	-	24	5072	c.5019A>G	c.(5017-5019)gcA>gcG	p.A1673A	SPTB_ENST00000389720.3_Silent_p.A1673A|SPTB_ENST00000389721.5_Silent_p.A1673A|SPTB_ENST00000556626.1_Silent_p.A1673A|SPTB_ENST00000542895.1_Silent_p.A1673A	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1673					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTTCAGCCCTGCGTAGTGCT	0.572000													8	237					0	0	0.335167	0	0
XIRP2	129446	broad.mit.edu	37	2	168099974	168099974	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:168099974C>A	ENST00000409195.1	+	9	2161	c.2072C>A	c.(2071-2073)aCt>aAt	p.T691N	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.T691N|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.T469N	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	516					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATGTCAAGACTGTGAGATAC	0.403000													53	92					7.77372e-23	8.5136e-23	0.870114	1	0
SYT15	83849	broad.mit.edu	37	10	46963839	46963839	+	Splice_Site	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:46963839C>T	ENST00000374323.3	-	6	1870		c.e6+1		SYT15_ENST00000374325.3_Splice_Site|SYT15_ENST00000503753.1_Splice_Site|RP11-38L15.3_ENST00000506914.1_RNA|SYT15_ENST00000374321.4_Splice_Site			Q9BQS2	SYT15_HUMAN	synaptotagmin XV							integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						TGTGGCCTTACTGTCCCCTTC	0.602000													9	45					0	0	0.335167	0	0
TBC1D3B	414059	broad.mit.edu	37	17	34493433	34493433	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:34493433G>A	ENST00000454519.3	-	14	1741	c.1592C>T	c.(1591-1593)tCa>tTa	p.S531L	CTB-91J4.1_ENST00000592460.1_RNA|TBC1D3B_ENST00000398801.3_Missense_Mutation_p.S531L	NM_001001417.5	NP_001001417.5	A6NDS4	TBC3B_HUMAN	TBC1 domain family, member 3B	531						intracellular	Rab GTPase activator activity			endometrium(2)|lung(3)|pancreas(1)	6		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		gcaaggccctgaggtgggagc	0.602000													72	147					0	0	0.870114	0	0
ADCY5	111	broad.mit.edu	37	3	123019001	123019001	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:123019001C>T	ENST00000462833.1	-	15	4078	c.2866G>A	c.(2866-2868)Gac>Aac	p.D956N	ADCY5_ENST00000309879.5_Missense_Mutation_p.D606N|ADCY5_ENST00000491190.1_Missense_Mutation_p.D589N	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	956					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCGGCGTTGTCGAAGAGCGTG	0.617000													4	59					0	0	0.184627	0	0
IGSF10	285313	broad.mit.edu	37	3	151156202	151156202	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:151156202T>C	ENST00000282466.3	-	6	6146	c.6147A>G	c.(6145-6147)caA>caG	p.Q2049Q	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2049	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CATGGAGCACTTGCTTTCTAA	0.443000													109	202					0	0	0.870114	0	0
UNC45B	146862	broad.mit.edu	37	17	33510469	33510469	+	Silent	SNP	C	C	T	rs74403538	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:33510469C>T	ENST00000268876.5	+	19	2500	c.2403C>T	c.(2401-2403)gaC>gaT	p.D801D	UNC45B_ENST00000378449.1_Silent_p.D720D|UNC45B_ENST00000433649.1_Silent_p.D799D|UNC45B_ENST00000591048.1_Silent_p.D720D|UNC45B_ENST00000394570.2_Silent_p.D799D	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	801					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TCTTGGCTGACGGGAATGACC	0.567000													22	49					0	0	0.706142	0	0
SEC14L1	6397	broad.mit.edu	37	17	75190814	75190814	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:75190814T>C	ENST00000413679.2	+	7	833	c.530T>C	c.(529-531)tTt>tCt	p.F177S	SEC14L1_ENST00000392476.2_Missense_Mutation_p.F177S|SEC14L1_ENST00000436233.4_Missense_Mutation_p.F177S|SEC14L1_ENST00000443798.4_Missense_Mutation_p.F177S|SEC14L1_ENST00000431431.2_Missense_Mutation_p.F143S|SEC14L1_ENST00000591437.1_Missense_Mutation_p.F143S|SEC14L1_ENST00000430767.4_Missense_Mutation_p.F177S|SEC14L1_ENST00000585618.1_Missense_Mutation_p.F177S	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	177					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						GGCATAACCTTTGTGCCCCGT	0.438000													6	236					0	0	0.307466	0	0
PML	5371	broad.mit.edu	37	15	74315449	74315449	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:74315449C>T	ENST00000565898.1	+	3	967	c.883C>T	c.(883-885)Cgc>Tgc	p.R295C	PML_ENST00000569477.1_Missense_Mutation_p.R295C|PML_ENST00000268058.3_Missense_Mutation_p.R295C|PML_ENST00000354026.6_Missense_Mutation_p.R295C|PML_ENST00000569161.1_3'UTR|PML_ENST00000567543.1_Missense_Mutation_p.R295C|PML_ENST00000359928.4_Missense_Mutation_p.R295C|PML_ENST00000569965.1_Missense_Mutation_p.R295C|PML_ENST00000435786.2_Missense_Mutation_p.R295C|PML_ENST00000395135.3_Missense_Mutation_p.R295C|PML_ENST00000436891.3_Missense_Mutation_p.R295C|PML_ENST00000563500.1_Missense_Mutation_p.R295C|PML_ENST00000395132.2_Missense_Mutation_p.R295C|PML_ENST00000564428.1_Missense_Mutation_p.R295C|PML_ENST00000268059.6_Missense_Mutation_p.R295C			P29590	PML_HUMAN	promyelocytic leukemia	295					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						GGCTCAGGAGCGCGAGCTGCT	0.731000			T	"""RARA, PAX5"""	"""APL, ALL"""								12	35					0	0	0.457914	0	0
NGEF	25791	broad.mit.edu	37	2	233839410	233839410	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:233839410A>G	ENST00000264051.3	-	2	469	c.191T>C	c.(190-192)aTc>aCc	p.I64T		NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	64	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GCGATTGAAGATGGAATTTCT	0.493000													141	299					0	0	0.870114	0	0
SMCR8	140775	broad.mit.edu	37	17	18219509	18219509	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:18219509G>A	ENST00000406438.3	+	1	886	c.406G>A	c.(406-408)Gtg>Atg	p.V136M		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	136										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						CTTTGCATACGTGCACCACCT	0.552000													65	135					0	0	0.870114	0	0
FTO	79068	broad.mit.edu	37	16	53922839	53922839	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:53922839A>G	ENST00000471389.1	+	7	1437	c.1215A>G	c.(1213-1215)gcA>gcG	p.A405A	FTO_ENST00000394647.3_Silent_p.A109A|FTO_ENST00000460382.1_Silent_p.A6A|FTO_ENST00000431610.2_Silent_p.A6A	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	405			A -> V (in dbSNP:rs16952624).		DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						AACTGGAAGCACTGTGGAAGA	0.502000													54	113					0	0	0.870114	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559558	129559558	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:129559558G>A	ENST00000422113.2	-	9	2488	c.2162C>T	c.(2161-2163)aCg>aTg	p.T721M	TMEM132D_ENST00000389441.4_Missense_Mutation_p.T259M	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	721						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATCCAAGGGCGTGACTGAGCC	0.468000													42	78					0	0	0.853193	0	0
OR5K4	403278	broad.mit.edu	37	3	98072884	98072884	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:98072884C>A	ENST00000354924.2	+	1	187	c.187C>A	c.(187-189)Ctg>Atg	p.L63M	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						GTACATCTTTCTGGGCAACCT	0.453000													303	528					1.03459e-158	1.17281e-158	0.870114	1	0
H2AFY2	55506	broad.mit.edu	37	10	71868887	71868887	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:71868887A>G	ENST00000373255.4	+	8	1141	c.877A>G	c.(877-879)Acc>Gcc	p.T293A	AIFM2_ENST00000373248.1_Intron	NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	293	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						GCTTGAAGAGACCATCAAAAA	0.557000													13	110					0	0	0.435327	0	0
NEB	4703	broad.mit.edu	37	2	152534241	152534241	+	Silent	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:152534241G>C	ENST00000427231.2	-	34	3814	c.3612C>G	c.(3610-3612)ggC>ggG	p.G1204G	NEB_ENST00000172853.10_Silent_p.G1204G|NEB_ENST00000409198.1_Silent_p.G1204G|NEB_ENST00000397345.3_Silent_p.G1204G|NEB_ENST00000603639.1_Silent_p.G1204G|NEB_ENST00000604864.1_Silent_p.G1204G	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1204					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGGAATCCAGCCAATGCCTT	0.453000													166	275					0	0	0.870114	0	0
DHX37	57647	broad.mit.edu	37	12	125467060	125467060	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:125467060T>G	ENST00000308736.2	-	3	484	c.386A>C	c.(385-387)aAa>aCa	p.K129T		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	129							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		AACTCACTCTTTGGTGTGATA	0.552000													168	332					0	0	0.870114	0	0
AEBP1	165	broad.mit.edu	37	7	44153558	44153558	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:44153558A>G	ENST00000223357.3	+	21	3480	c.3175A>G	c.(3175-3177)Acc>Gcc	p.T1059A	AEBP1_ENST00000450684.2_Missense_Mutation_p.T634A	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	1059	Interaction with MAPK1 and MAPK3 (By similarity).|Required for transcriptional repression (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						TGCCCCTGCCACCACCCTGAG	0.682000													4	9					0	0	0.217242	0	0
ATP2C2	9914	broad.mit.edu	37	16	84495688	84495688	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:84495688T>C	ENST00000416219.2	+	27	2851	c.2762T>C	c.(2761-2763)aTc>aCc	p.I921T	RP11-517C16.2_ENST00000565700.1_RNA|ATP2C2_ENST00000262429.4_Missense_Mutation_p.I892T|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	892					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						GTCATTTACATCCCCCCGCTG	0.612000													55	117					0	0	0.870114	0	0
LRP1	4035	broad.mit.edu	37	12	57605026	57605026	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:57605026C>T	ENST00000243077.3	+	84	13450	c.12984C>T	c.(12982-12984)tgC>tgT	p.C4328C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4328	EGF-like 20.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGACAATGCCGCTGCACTG	0.582000													13	32					0	0	0.539581	0	0
MRE11A	4361	broad.mit.edu	37	11	94203744	94203744	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:94203744C>T	ENST00000323929.3	-	9	1132	c.910G>A	c.(910-912)Gtg>Atg	p.V304M	MRE11A_ENST00000323977.3_Missense_Mutation_p.V304M|MRE11A_ENST00000407439.3_Missense_Mutation_p.V307M|MRE11A_ENST00000393241.4_Missense_Mutation_p.V304M	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	304					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				AACTGCCGCACTGTGTGAAGA	0.398000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				5	147					0	0	0.217242	0	0
YTHDF1	54915	broad.mit.edu	37	20	61845285	61845285	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:61845285A>G	ENST00000370339.3	-	3	404	c.63T>C	c.(61-63)ggT>ggC	p.G21G	YTHDF1_ENST00000370334.4_Silent_p.G21G	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	21										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GATGTAACGAACCATTTTGTA	0.328000													24	82					0	0	0.819951	0	0
EOGT	285203	broad.mit.edu	37	3	69047200	69047200	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:69047200A>C	ENST00000383701.3	-	10	1535	c.793T>G	c.(793-795)Tca>Gca	p.S265A	EOGT_ENST00000540764.1_Missense_Mutation_p.S164A|EOGT_ENST00000295571.5_Missense_Mutation_p.S265A|EOGT_ENST00000540955.1_Intron	NM_001278689.1	NP_001265618.1			EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase																		GTACTGAATGAGTTATTAACG	0.388000													95	81					0	0	0.870114	0	0
LRRC27	80313	broad.mit.edu	37	10	134161565	134161565	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:134161565A>G	ENST00000392638.2	+	6	826	c.631A>G	c.(631-633)Aac>Gac	p.N211D	LRRC27_ENST00000368612.1_Missense_Mutation_p.N149D|LRRC27_ENST00000368614.3_Missense_Mutation_p.N211D|LRRC27_ENST00000344079.5_Missense_Mutation_p.N211D|LRRC27_ENST00000356571.4_3'UTR|LRRC27_ENST00000432555.2_Missense_Mutation_p.N84D|LRRC27_ENST00000368610.3_Missense_Mutation_p.N149D|LRRC27_ENST00000368613.4_Missense_Mutation_p.N211D|LRRC27_ENST00000368615.3_Missense_Mutation_p.N211D			Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27	211										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	18		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CCACGCGTCTAACCAAGGAGC	0.572000													55	113					0	0	0.870114	0	0
PHB	5245	broad.mit.edu	37	17	47484173	47484173	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:47484173G>A	ENST00000300408.3	-	6	626	c.554C>T	c.(553-555)gCc>gTc	p.A185V	RP11-81K2.1_ENST00000576461.1_Intron|PHB_ENST00000511832.1_Intron|PHB_ENST00000508009.1_5'UTR	NM_002634.2	NP_002625.1	P35232	PHB_HUMAN	prohibitin	185					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding			endometrium(4)|large_intestine(2)|lung(4)	10	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			CACCTGTTTGGCTTCCACCGC	0.557000													25	51					0	0	0.717897	0	0
STAT6	6778	broad.mit.edu	37	12	57498535	57498535	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:57498535A>G	ENST00000300134.3	-	10	1388	c.1063T>C	c.(1063-1065)Tgc>Cgc	p.C355R	STAT6_ENST00000556155.1_Missense_Mutation_p.C355R|STAT6_ENST00000543873.2_Missense_Mutation_p.C355R|STAT6_ENST00000538913.2_Missense_Mutation_p.C245R|STAT6_ENST00000537215.2_Missense_Mutation_p.C245R|STAT6_ENST00000454075.3_Missense_Mutation_p.C355R	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	355					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						GCAGAGCAGCAGTTCCCAGGA	0.562000													39	57					0	0	0.840704	0	0
FBXL14	144699	broad.mit.edu	37	12	1702059	1702059	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:1702059G>A	ENST00000339235.3	-	1	1272	c.1174C>T	c.(1174-1176)Cag>Tag	p.Q392*	WNT5B_ENST00000537031.1_Intron|FBXL14_ENST00000543278.1_Intron	NM_152441.2	NP_689654.1	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	392						cytoplasm				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	8	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			TCCGTCATCTGCCAGAGTCCC	0.632000													30	43					0	0	0.819951	0	0
ZBTB44	29068	broad.mit.edu	37	11	130131061	130131061	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:130131061A>G	ENST00000525842.1	-	2	1075	c.708T>C	c.(706-708)atT>atC	p.I236I	ZBTB44_ENST00000357899.4_Silent_p.I236I|ZBTB44_ENST00000397753.1_Silent_p.I236I|ZBTB44_ENST00000530205.1_Silent_p.I236I	NM_014155.4	NP_054874.3	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		TCCTTCGATCAATTCCAAAAG	0.428000													39	66					0	0	0.796494	0	0
ENG	2022	broad.mit.edu	37	9	130579468	130579468	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:130579468A>G	ENST00000344849.3	-	13	1981	c.1701T>C	c.(1699-1701)acT>acC	p.T567T	ENG_ENST00000373203.4_Silent_p.T567T|ENG_ENST00000480266.1_5'UTR|RP11-228B15.4_ENST00000439298.1_RNA			P17813	EGLN_HUMAN	endoglin	567	Ser/Thr-rich.				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	17						GCATGAAGACAGTCCTATGGA	0.577000									Juvenile Polyposis;Hereditary Hemorrhagic Telangiectasia				8	12					0	0	0.335167	0	0
QSER1	79832	broad.mit.edu	37	11	32953741	32953741	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:32953741C>T	ENST00000399302.2	+	4	885	c.550C>T	c.(550-552)Cga>Tga	p.R184*	QSER1_ENST00000527788.1_Nonsense_Mutation_p.R184*	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	184	Ser-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					AGCTCTTCTTCGAGAATGTAG	0.453000													69	153					0	0	0.870114	0	0
RANBP2	5903	broad.mit.edu	37	2	109371408	109371408	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:109371408G>A	ENST00000283195.6	+	16	2376	c.2250G>A	c.(2248-2250)atG>atA	p.M750I		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	750					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						ATTCAGTCATGCAGGAACTCG	0.373000													161	336					0	0	0.870114	0	0
TMCC1	23023	broad.mit.edu	37	3	129546961	129546961	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:129546961G>A	ENST00000393238.3	-	3	601	c.261C>T	c.(259-261)aaC>aaT	p.N87N	TMCC1_ENST00000426664.2_Intron	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	87						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						CAGCACATGCGTTCTGGCTTT	0.532000													16	107					0	0	0.500413	0	0
COL14A1	7373	broad.mit.edu	37	8	121216054	121216054	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:121216054G>C	ENST00000297848.3	+	9	1254	c.984G>C	c.(982-984)gaG>gaC	p.E328D	COL14A1_ENST00000247781.3_Missense_Mutation_p.E233D|COL14A1_ENST00000309791.4_Missense_Mutation_p.E328D|COL14A1_ENST00000537875.1_Missense_Mutation_p.E328D|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	328	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CAGTTGTGGAGAGTCTGACCA	0.468000													18	35					0	0	0.624587	0	0
PLCB3	5331	broad.mit.edu	37	11	64024202	64024202	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:64024202C>A	ENST00000540288.1	+	10	1081	c.978C>A	c.(976-978)taC>taA	p.Y326*	PLCB3_ENST00000279230.6_Nonsense_Mutation_p.Y326*|PLCB3_ENST00000325234.5_Nonsense_Mutation_p.Y259*	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	326	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						TGAGTGCCTACTTCATCAACT	0.607000													29	56					3.33393e-15	3.56298e-15	0.804634	1	0
MCTP1	79772	broad.mit.edu	37	5	94253679	94253679	+	Splice_Site	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:94253679C>T	ENST00000515393.1	-	8	1272		c.e8-1		MCTP1_ENST00000312216.8_Splice_Site|MCTP1_ENST00000429576.2_Intron|MCTP1_ENST00000505208.1_Splice_Site|MCTP1_ENST00000505078.1_Intron	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TGCCGCACGTCTGGATGGAAA	0.438000													24	53					0	0	0.760397	0	0
ISY1-RAB43	100534599	broad.mit.edu	37	3	128864606	128864606	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:128864606C>T	ENST00000418265.1	-	6	358	c.298G>A	c.(298-300)Gga>Aga	p.G100R	ISY1_ENST00000393292.3_Missense_Mutation_p.G100R|ISY1_ENST00000393295.3_Missense_Mutation_p.G100R|ISY1_ENST00000471497.1_5'UTR|ISY1_ENST00000273541.8_Missense_Mutation_p.G100R	NM_001204890.1	NP_001191819.1	Q9ULR0	ISY1_HUMAN		100						catalytic step 2 spliceosome											GTACTCACTCCATAATCAGGA	0.488000													5	94					0	0	0.217242	0	0
MYH8	4626	broad.mit.edu	37	17	10299971	10299971	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:10299971T>C	ENST00000403437.2	-	32	4521	c.4427A>G	c.(4426-4428)gAg>gGg	p.E1476G	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1476					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AGAACGTGACTCCTTCTGGGA	0.433000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				55	97					0	0	0.870114	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139363	178139363	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:178139363T>A	ENST00000335815.2	-	5	1713	c.1516A>T	c.(1516-1518)Aac>Tac	p.N506Y		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	506					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		AGTGATGAGTTACACCTGAAT	0.398000													90	178					0	0	0.870114	0	0
GPR180	160897	broad.mit.edu	37	13	95264569	95264569	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:95264569A>G	ENST00000376958.4	+	3	455	c.430A>G	c.(430-432)Atc>Gtc	p.I144V		NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180	144						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					GGTGGAAGATATCCCATTTGA	0.403000													71	172					0	0	0.870114	0	0
ATRNL1	26033	broad.mit.edu	37	10	117093811	117093811	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:117093811T>C	ENST00000355044.3	+	19	3183	c.3057T>C	c.(3055-3057)caT>caC	p.H1019H	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Intron	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1019	Laminin EGF-like 1.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTAATGGACATAGCACTTGCA	0.338000													45	74					0	0	0.859065	0	0
TP53I3	9540	broad.mit.edu	37	2	24305872	24305872	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:24305872G>A	ENST00000238721.4	-	2	1143	c.289C>T	c.(289-291)Cag>Tag	p.Q97*	TP53I3_ENST00000313482.4_Nonsense_Mutation_p.Q97*|FAM228B_ENST00000461972.1_Intron|TP53I3_ENST00000417886.1_5'UTR|TP53I3_ENST00000407482.1_Nonsense_Mutation_p.Q97*|TP53I3_ENST00000335934.4_Nonsense_Mutation_p.Q97*	NM_004881.4	NP_004872.2	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	97					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(3)|urinary_tract(2)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGACGTACTGAGCCTGGCCC	0.652000													29	59					0	0	0.729181	0	0
CAGE1	285782	broad.mit.edu	37	6	7334269	7334269	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:7334269T>C	ENST00000502583.1	-	12	2988	c.2424A>G	c.(2422-2424)aaA>aaG	p.K808K	SSR1_ENST00000488834.1_5'UTR|CAGE1_ENST00000512086.1_Silent_p.K746K|CAGE1_ENST00000379918.4_Silent_p.K786K|CAGE1_ENST00000338150.4_Silent_p.K773K|CAGE1_ENST00000296742.7_Silent_p.K610K	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	746										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					GTTTTCTGGCTTTTTCTCTGG	0.323000													6	5					0	0	0.217242	0	0
ZNF586	54807	broad.mit.edu	37	19	58290702	58290702	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:58290702T>C	ENST00000396150.4	+	2	767	c.620T>C	c.(619-621)tTa>tCa	p.L207S	ZNF586_ENST00000598183.1_Intron|ZNF586_ENST00000599802.1_Intron|ZNF586_ENST00000396154.2_Silent_p.L249L|ZNF586_ENST00000391702.3_Silent_p.L206L|ZNF586_ENST00000598885.1_Intron	NM_001077426.2	NP_001070894.1	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)	15		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTCCAGTCTTATTAAACACT	0.438000													56	98					0	0	0.870114	0	0
SELPLG	6404	broad.mit.edu	37	12	109017315	109017315	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:109017315C>G	ENST00000388962.3	-	3	898	c.739G>C	c.(739-741)Gca>Cca	p.A247P	SELPLG_ENST00000228463.6_Missense_Mutation_p.A273P|SELPLG_ENST00000550948.1_Missense_Mutation_p.A257P	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	257	12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						TCCATGGCTGCCAGTGGAGTG	0.582000													33	43					0	0	0.870114	0	0
KPNB1	3837	broad.mit.edu	37	17	45757396	45757396	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:45757396G>A	ENST00000290158.4	+	20	2771	c.2364G>A	c.(2362-2364)atG>atA	p.M788I	KPNB1_ENST00000540627.1_Missense_Mutation_p.M643I|KPNB1_ENST00000537679.1_Missense_Mutation_p.M572I|KPNB1_ENST00000535458.2_Missense_Mutation_p.M643I	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	788					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						CGGATGTGATGCTGGTACAAC	0.493000													78	129					0	0	0.870114	0	0
SMC6	79677	broad.mit.edu	37	2	17902257	17902257	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:17902257T>G	ENST00000448223.2	-	11	1164	c.895A>C	c.(895-897)Att>Ctt	p.I299L	SMC6_ENST00000351948.4_Missense_Mutation_p.I299L|SMC6_ENST00000381272.4_Missense_Mutation_p.I325L|SMC6_ENST00000402989.1_Missense_Mutation_p.I299L	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	299					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCTTCTCCAATTTTGATATTA	0.289000													8	169					0	0	0.335167	0	0
MMEL1	79258	broad.mit.edu	37	1	2524327	2524327	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:2524327T>C	ENST00000288709.6	-	20	2159	c.1919A>G	c.(1918-1920)gAg>gGg	p.E640G	MMEL1_ENST00000378412.3_Missense_Mutation_p.E649G|MMEL1_ENST00000502556.1_Missense_Mutation_p.E492G	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	649					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GATCATGCACTCTGACTGCTC	0.612000													29	24					0	0	0.760397	0	0
SOAT1	6646	broad.mit.edu	37	1	179316774	179316774	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:179316774A>G	ENST00000367619.3	+	12	1300	c.1157A>G	c.(1156-1158)cAc>cGc	p.H386R	SOAT1_ENST00000539888.1_Missense_Mutation_p.H321R|SOAT1_ENST00000535686.1_Missense_Mutation_p.H122R|SOAT1_ENST00000540564.1_Missense_Mutation_p.H328R	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	386					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCCTTTTTGCACTGCTGGCTC	0.338000													53	128					0	0	0.870114	0	0
COL4A4	1286	broad.mit.edu	37	2	227945177	227945177	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:227945177T>C	ENST00000396625.3	-	24	1992	c.1785A>G	c.(1783-1785)aaA>aaG	p.K595K	COL4A4_ENST00000329662.7_Silent_p.K595K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	595	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTGGATCCCCTTTTTCTCCAG	0.463000													4	277					0	0	0.150653	0	0
NGF	4803	broad.mit.edu	37	1	115829215	115829215	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:115829215G>A	ENST00000369512.2	-	3	370	c.202C>T	c.(202-204)Cgc>Tgc	p.R68C	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	68					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GTAATGTTGCGGGTCTGCCCC	0.622000													15	17					0	0	0.539581	0	0
CNST	163882	broad.mit.edu	37	1	246810501	246810501	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:246810501T>C	ENST00000366513.4	+	9	1267	c.998T>C	c.(997-999)cTg>cCg	p.L333P	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.L333P	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	333					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GTGGAGCCCCTGGGGAGCAGT	0.458000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	114					0	0	0.870114	0	0
MAST4	375449	broad.mit.edu	37	5	66386058	66386058	+	Splice_Site	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:66386058A>T	ENST00000404260.3	+	6	1140	c.833_splice	c.e6+1	p.S278_splice	MAST4_ENST00000490016.2_Splice_Site_p.R89_splice|MAST4_ENST00000405643.1_Splice_Site_p.R96_splice|MAST4_ENST00000261569.7_Splice_Site_p.R84_splice|MAST4_ENST00000403625.2_Splice_Site_p.R278_splice|MAST4_ENST00000403666.1_Splice_Site_p.R89_splice			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	278						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		ATTTGCACGGAGGTAAGGACT	0.468000													11	29					0	0	0.435327	0	0
ZFHX3	463	broad.mit.edu	37	16	72845484	72845484	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:72845484T>C	ENST00000268489.5	-	7	4528	c.3856A>G	c.(3856-3858)Att>Gtt	p.I1286V	ZFHX3_ENST00000397992.5_Missense_Mutation_p.I372V	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1286					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACCGTCATAATGAGCTTCTCC	0.552000													17	19					0	0	0.592651	0	0
ADCY7	113	broad.mit.edu	37	16	50328621	50328621	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:50328621G>C	ENST00000394697.2	+	7	1247	c.907G>C	c.(907-909)Gtg>Ctg	p.V303L	ADCY7_ENST00000566433.2_Missense_Mutation_p.V303L|ADCY7_ENST00000254235.3_Missense_Mutation_p.V303L|ADCY7_ENST00000564044.1_3'UTR|ADCY7_ENST00000538642.1_Missense_Mutation_p.V303L|ADCY7_ENST00000537579.1_Missense_Mutation_p.V303L			P51828	ADCY7_HUMAN	adenylate cyclase 7	303	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GCTGGTGGTGGTGCTGAATGA	0.617000													11	17					0	0	0.435327	0	0
MYO6	4646	broad.mit.edu	37	6	76589611	76589611	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:76589611T>C	ENST00000369981.3	+	21	2431	c.2152T>C	c.(2152-2154)Tac>Cac	p.Y718H	MYO6_ENST00000462633.1_3'UTR|MYO6_ENST00000369985.4_Missense_Mutation_p.Y718H|MYO6_ENST00000369975.1_Missense_Mutation_p.Y718H|MYO6_ENST00000369977.3_Missense_Mutation_p.Y718H			Q9UM54	MYO6_HUMAN	myosin VI	718	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		CTACAACATGTACAAAAAGTA	0.383000													91	181					0	0	0.870114	0	0
IDH3G	3421	broad.mit.edu	37	X	153059774	153059774	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:153059774A>G	ENST00000370092.3	-	1	193	c.8T>C	c.(7-9)cTg>cCg	p.L3P	IDH3G_ENST00000217901.5_Missense_Mutation_p.L3P|IDH3G_ENST00000370093.1_Missense_Mutation_p.L3P|IDH3G_ENST00000427365.2_5'UTR|SSR4_ENST00000320857.3_5'UTR|SSR4_ENST00000370087.1_5'UTR|IDH3G_ENST00000497043.1_5'UTR	NM_174869.2	NP_777358.1	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma	3					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)	17	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	CGCTACCTTCAGCGCCATGAC	0.687000													10	9					0	0	0.361761	0	0
CCDC104	112942	broad.mit.edu	37	2	55749245	55749245	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:55749245T>C	ENST00000349456.4	+	2	271	c.123T>C	c.(121-123)gaT>gaC	p.D41D	CCDC104_ENST00000339012.3_Silent_p.D66D|CCDC104_ENST00000407816.3_Silent_p.D41D|CCDC104_ENST00000403007.3_Silent_p.D41D|CCDC104_ENST00000406691.3_Silent_p.D41D			Q96G28	CC104_HUMAN	coiled-coil domain containing 104	41										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(2)|lung(1)|ovary(2)	14			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TAGTTTTTGATGATGAAGAAG	0.254000													17	46					0	0	0.520397	0	0
SYNGR3	9143	broad.mit.edu	37	16	2043042	2043042	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:2043042G>A	ENST00000248121.2	+	4	817	c.659G>A	c.(658-660)aGc>aAc	p.S220N	SYNGR3_ENST00000562045.1_3'UTR	NM_004209.5	NP_004200.2	O43761	SNG3_HUMAN	synaptogyrin 3	220					positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle				endometrium(1)|lung(2)	3						CTGGACACCAGCCCCAAAGGG	0.711000													8	14					0	0	0.307466	0	0
SLC12A8	84561	broad.mit.edu	37	3	124930170	124930170	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:124930170C>T	ENST00000393469.4	-	1	73	c.24G>A	c.(22-24)caG>caA	p.Q8Q	SLC12A8_ENST00000469902.1_Silent_p.Q8Q|SLC12A8_ENST00000423114.2_Intron|SLC12A8_ENST00000314584.7_5'UTR	NM_001195483.1	NP_001182412.1	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	8					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GGAAGAGCTCCTGCACCTGGG	0.602000													6	248					0	0	0.248553	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617102	77617102	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:77617102T>C	ENST00000521891.2	+	2	1227	c.779T>C	c.(778-780)gTg>gCg	p.V260A	ZFHX4_ENST00000455469.2_Missense_Mutation_p.V260A|ZFHX4_ENST00000050961.6_Missense_Mutation_p.V260A|ZFHX4_ENST00000518282.1_Missense_Mutation_p.V260A|ZFHX4_ENST00000517683.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	260						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTAACAATGTGGACTTGTCC	0.413000										HNSCC(33;0.089)			35	71					0	0	0.796494	0	0
ZNF234	10780	broad.mit.edu	37	19	44661005	44661005	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:44661005A>G	ENST00000426739.2	+	6	1094	c.836A>G	c.(835-837)cAg>cGg	p.Q279R	ZNF234_ENST00000592437.1_Missense_Mutation_p.Q279R	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				CAGGAACATCAGAGAATTCAT	0.413000													105	226					0	0	0.870114	0	0
NF2	4771	broad.mit.edu	37	22	30051666	30051666	+	Splice_Site	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:30051666G>A	ENST00000338641.4	+	6	1040		c.e6+1		NF2_ENST00000413209.2_Intron|NF2_ENST00000361166.4_Splice_Site|NF2_ENST00000334961.7_Splice_Site|NF2_ENST00000403435.1_Splice_Site|NF2_ENST00000353887.4_Splice_Site|NF2_ENST00000361452.4_Splice_Site|NF2_ENST00000397789.3_Splice_Site|NF2_ENST00000347330.5_Intron|NF2_ENST00000403999.3_Splice_Site|NF2_ENST00000361676.4_Splice_Site	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)						actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(5)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						GCCGAGCCAGGTGAGGCCCAT	0.408000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				28	39					0	0	0.769981	0	0
PLCD1	5333	broad.mit.edu	37	3	38050545	38050545	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:38050545C>A	ENST00000463876.1	-	11	2127	c.1774G>T	c.(1774-1776)Ggc>Tgc	p.G592C	PLCD1_ENST00000334661.4_Missense_Mutation_p.G571C	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	571	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		ATCTGGCAGCCCCCATTCCAC	0.642000													9	11					0.000978159	0.00100202	0.387290	1	0
RNF31	55072	broad.mit.edu	37	14	24619565	24619565	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:24619565C>T	ENST00000324103.6	+	7	1425	c.1105C>T	c.(1105-1107)Cta>Tta	p.L369L	RNF31_ENST00000382687.3_Silent_p.L218L|RNF31_ENST00000559275.1_Silent_p.L218L	NM_017999.4	NP_060469.4	Q96EP0	RNF31_HUMAN	ring finger protein 31	369	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(4)|skin(2)|soft_tissue(1)	39				GBM - Glioblastoma multiforme(265;0.00861)		AGCTGCTGTGCTATGTTCCAT	0.587000													32	53					0	0	0.788014	0	0
CEP152	22995	broad.mit.edu	37	15	49076301	49076301	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:49076301C>T	ENST00000380950.2	-	10	1377	c.1190G>A	c.(1189-1191)cGt>cAt	p.R397H	CEP152_ENST00000399334.3_Missense_Mutation_p.R397H|RP11-485O10.2_ENST00000558304.1_RNA|CEP152_ENST00000325747.5_Missense_Mutation_p.R304H	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	397					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		ATCTTTCAGACGAGAGCAAAT	0.303000													29	62					0	0	0.729181	0	0
FAT1	2195	broad.mit.edu	37	4	187540370	187540370	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:187540370A>G	ENST00000441802.2	-	10	7579	c.7370T>C	c.(7369-7371)cTg>cCg	p.L2457P		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2457	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AAATGGCTTCAGGGCGTGCCG	0.438000										HNSCC(5;0.00058)			115	99					0	0	0.870114	0	0
BAHCC1	57597	broad.mit.edu	37	17	79409727	79409727	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:79409727A>T	ENST00000307745.7	+	9	1352	c.1352A>T	c.(1351-1353)gAg>gTg	p.E451V																								GGCAAGGGCGAGCGGCGGCCT	0.701000													5	4					0	0	0.278610	0	0
LRRC43	254050	broad.mit.edu	37	12	122674785	122674785	+	Silent	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:122674785A>T	ENST00000339777.4	+	5	799	c.771A>T	c.(769-771)ggA>ggT	p.G257G	LRRC43_ENST00000425921.1_Silent_p.G72G	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	257										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		TGCTGCAGGGAAACCCACTGG	0.637000													41	83					0	0	0.870114	0	0
HEATR5B	54497	broad.mit.edu	37	2	37291914	37291914	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:37291914C>G	ENST00000233099.5	-	10	1648	c.1553G>C	c.(1552-1554)tGt>tCt	p.C518S	HEATR5B_ENST00000354531.2_Missense_Mutation_p.C518S	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	518							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GCCCAAAGGACACTGATGTAC	0.488000													40	103					0	0	0.827153	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372644	74372644	+	RNA	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:74372644A>G	ENST00000429810.2	-	0	1552																											TACCCTTGTCAGGGGGAACAA	0.443000													7	26					0	0	0.248553	0	0
TRIOBP	11078	broad.mit.edu	37	22	38168624	38168624	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:38168624C>T	ENST00000406386.3	+	23	7208	c.6953C>T	c.(6952-6954)tCg>tTg	p.S2318L	RP1-37E16.12_ENST00000455236.1_RNA|TRIOBP_ENST00000403663.2_Missense_Mutation_p.S605L	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2318					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CGCTTCACCTCGGGAAAGTAC	0.622000													59	32					0	0	0.870114	0	0
ZNF846	162993	broad.mit.edu	37	19	9868821	9868821	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:9868821A>G	ENST00000397902.2	-	6	1345	c.932T>C	c.(931-933)gTa>gCa	p.V311A	ZNF846_ENST00000588267.1_Missense_Mutation_p.V182A|ZNF846_ENST00000592859.1_Missense_Mutation_p.V182A|ZNF846_ENST00000586293.1_3'UTR	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						TTCCATACATACATAGGGCTT	0.398000													4	166					0	0	0.217242	0	0
TLR10	81793	broad.mit.edu	37	4	38775818	38775818	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:38775818A>G	ENST00000308973.4	-	4	1999	c.1394T>C	c.(1393-1395)cTg>cCg	p.L465P	TLR10_ENST00000508334.1_Missense_Mutation_p.L465P|TLR10_ENST00000361424.2_Missense_Mutation_p.L465P|TLR10_ENST00000506111.1_Missense_Mutation_p.L465P	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	465					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						TAAGGCCATCAGATGAATAGT	0.348000													96	84					0	0	0.870114	0	0
ZNF462	58499	broad.mit.edu	37	9	109734321	109734321	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:109734321C>T	ENST00000277225.5	+	8	6752	c.6463C>T	c.(6463-6465)Cag>Tag	p.Q2155*	ZNF462_ENST00000542028.1_Nonsense_Mutation_p.Q112*|ZNF462_ENST00000441147.2_Nonsense_Mutation_p.Q1061*|ZNF462_ENST00000457913.1_Nonsense_Mutation_p.Q2215*			Q96JM2	ZN462_HUMAN	zinc finger protein 462	2155					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TGTTCAGCAGCAGTTGAACCA	0.517000													5	77					0	0	0.217242	0	0
ATG4A	115201	broad.mit.edu	37	X	107381402	107381402	+	Nonsense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:107381402T>G	ENST00000372232.3	+	9	954	c.795T>G	c.(793-795)taT>taG	p.Y265*	ATG4A_ENST00000545696.1_Intron|ATG4A_ENST00000372254.3_Nonsense_Mutation_p.Y241*|ATG4A_ENST00000345734.3_Intron	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	265					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						ATAACGCGTATTATTTCATAG	0.458000													113	97					0	0	0.870114	0	0
WLS	79971	broad.mit.edu	37	1	68614299	68614299	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:68614299G>A	ENST00000262348.4	-	7	1270	c.1017C>T	c.(1015-1017)gtC>gtT	p.V339V	GNG12-AS1_ENST00000413628.1_RNA|WLS_ENST00000491811.1_5'UTR|GNG12-AS1_ENST00000420587.1_RNA|WLS_ENST00000370976.3_Silent_p.V248V|WLS_ENST00000354777.2_Silent_p.V337V|WLS_ENST00000540432.1_Silent_p.V339V	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	339					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						CAATGGGTCCGACTTGCTTCC	0.512000													12	14					0	0	0.500413	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71189971	71189971	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:71189971G>A	ENST00000234396.4	+	9	923	c.850G>A	c.(850-852)Gag>Aag	p.E284K	ATP6V1B1_ENST00000412314.1_Missense_Mutation_p.E284K|AC007040.11_ENST00000606025.1_Intron	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	284					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CTACCAGTGTGAGAAGCATGT	0.582000													33	67					0	0	0.769981	0	0
THOC6	79228	broad.mit.edu	37	16	3076526	3076526	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:3076526C>A	ENST00000326266.8	+	7	717	c.421C>A	c.(421-423)Ctc>Atc	p.L141I	THOC6_ENST00000574549.1_Missense_Mutation_p.L117I|THOC6_ENST00000253952.9_Missense_Mutation_p.L141I|THOC6_ENST00000575576.1_Missense_Mutation_p.L117I	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	141					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						GGAGAATTCCCTCATCCTGGC	0.522000													16	33					7.41877e-09	7.76061e-09	0.608945	1	0
SNRNP200	23020	broad.mit.edu	37	2	96943382	96943382	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:96943382A>G	ENST00000323853.5	-	41	5903	c.5826T>C	c.(5824-5826)gcT>gcC	p.A1942A	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1942	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CCAGTTCCATAGCTGCCAGAG	0.547000													35	63					0	0	0.827153	0	0
CD1B	910	broad.mit.edu	37	1	158301156	158301156	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:158301156G>A	ENST00000368168.3	-	1	165	c.58C>T	c.(58-60)Cat>Tat	p.H20Y		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	20					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					CTCTTACCATGTTCACTGTTA	0.483000													22	51					0	0	0.667858	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100491	27100491	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:27100491C>T	ENST00000607124.1	-	1	38	c.39G>A	c.(37-39)aaG>aaA	p.K13K	HIST1H2BJ_ENST00000541790.1_Silent_p.K13K|HIST1H2BJ_ENST00000339812.2_Silent_p.K13K			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	13					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						TCTTGGAGCCCTTTTTCGGGG	0.532000													4	152					0	0	0.150653	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45523258	45523258	+	Missense_Mutation	SNP	G	G	A	rs138635982	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr21:45523258G>A	ENST00000291574.4	+	23	3801	c.3626G>A	c.(3625-3627)aGc>aAc	p.S1209N		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1209					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						AGCAGGGGCAGCGTGCATTCG	0.627000													5	15					0	0	0.307466	0	0
PIK3CD	5293	broad.mit.edu	37	1	9781596	9781596	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:9781596C>T	ENST00000536656.1	+	15	2186	c.1978C>T	c.(1978-1980)Cgg>Tgg	p.R660W	PIK3CD_ENST00000361110.2_Missense_Mutation_p.R660W|PIK3CD_ENST00000377346.4_Missense_Mutation_p.R636W|PIK3CD_ENST00000543390.1_Missense_Mutation_p.R303W			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	636					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGCTGGACCGGGCCCTGGC	0.617000											OREG0013082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	15					0	0	0.479597	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669127	234669127	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:234669127C>T	ENST00000360418.3	+	1	194	c.194C>T	c.(193-195)tCg>tTg	p.S65L	UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A1_ENST00000305208.5_Missense_Mutation_p.S65L|UGT1A7_ENST00000373426.3_Intron			P22309	UD11_HUMAN		65					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCTGACGCCTCGTTGTACATC	0.517000													21	229					0	0	0.592651	0	0
DISP2	85455	broad.mit.edu	37	15	40661343	40661343	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:40661343C>T	ENST00000267889.3	+	8	3117	c.3030C>T	c.(3028-3030)ctC>ctT	p.L1010L	RP11-64K12.4_ENST00000558421.1_RNA	NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	1010					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TGGTTCTCCTCGAGTGGCAGC	0.587000													15	25					0	0	0.654019	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128851410	128851410	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:128851410T>C	ENST00000310343.9	-	16	1638	c.1639A>G	c.(1639-1641)Atg>Gtg	p.M547V	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.M473V|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.M198V|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.M198V	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	547	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTCACTTCCATGAAAGCTGCT	0.473000													5	145					0	0	0.217242	0	0
C9orf96	169436	broad.mit.edu	37	9	136255356	136255356	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:136255356T>C	ENST00000371957.3	+	6	550	c.443T>C	c.(442-444)cTg>cCg	p.L148P	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	148	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTGGAATACCTGCACCATTTG	0.622000													12	14					0	0	0.457914	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:7578212G>A	ENST00000420246.2	-	6	769	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_ENST00000413465.2_Nonsense_Mutation_p.R213*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R213*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R213*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R213*|TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.R213*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(250)|p.R81*(21)|p.R120*(21)|p.0?(8)|p.?(5)|p.R213G(5)|p.R213fs*35(3)|p.R213fs*34(3)|p.D208_V216delDRNTFRHSV(1)|p.R120G(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R120fs*35(1)|p.R81G(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	56					0	0	0.654019	0	0
SPG11	80208	broad.mit.edu	37	15	44888371	44888371	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:44888371G>A	ENST00000261866.7	-	25	4360	c.4344C>T	c.(4342-4344)tgC>tgT	p.C1448C	SPG11_ENST00000535302.2_Silent_p.C1448C|SPG11_ENST00000427534.2_Silent_p.C1448C|SPG11_ENST00000558319.1_Silent_p.C1448C	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1448					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GCTCCTCTGAGCATTGGAGCA	0.498000													49	103					0	0	0.870114	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826136	43826136	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:43826136G>A	ENST00000389420.3	-	21	3066	c.3067C>T	c.(3067-3069)Ccc>Tcc	p.P1023S	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.P1023S|ADAMTS20_ENST00000395541.2_Missense_Mutation_p.P177S	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1023	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCCCAACTGGGACAGGAAAAT	0.383000													25	52					0	0	0.667858	0	0
DLG5	9231	broad.mit.edu	37	10	79567599	79567599	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:79567599T>C	ENST00000372391.2	-	25	4756	c.4751A>G	c.(4750-4752)gAg>gGg	p.E1584G	DLG5_ENST00000372388.2_Missense_Mutation_p.E1244G|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1584					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTTCGTGAACTCCTCAGGGCG	0.592000													3	92					0	0	0.150653	0	0
DYRK4	8798	broad.mit.edu	37	12	4721810	4721810	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:4721810G>T	ENST00000540757.2	+	12	1407	c.1247G>T	c.(1246-1248)aGg>aTg	p.R416M	DYRK4_ENST00000010132.5_Missense_Mutation_p.R416M|DYRK4_ENST00000545342.1_Missense_Mutation_p.R53M|DYRK4_ENST00000543431.1_Missense_Mutation_p.R416M	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	416						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			CAGACCCTGAGGAAATCCAAT	0.532000													36	118					2.47872e-24	2.71818e-24	0.853193	1	0
EVI2A	2123	broad.mit.edu	37	17	29647410	29647410	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:29647410C>T	ENST00000247270.3	-	2	376	c.40G>A	c.(40-42)Gcc>Acc	p.A14T	EVI2A_ENST00000462804.2_Intron|NF1_ENST00000356175.3_Intron|NF1_ENST00000581113.2_Intron|EVI2A_ENST00000461237.1_Intron|NF1_ENST00000358273.4_Intron	NM_001003927.2	NP_001003927.1	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A	0						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		ataggtagggcctgaaagtct	0.348000													7	110					0	0	0.248553	0	0
MYH10	4628	broad.mit.edu	37	17	8421992	8421992	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:8421992T>G	ENST00000360416.3	-	21	2599	c.2461A>C	c.(2461-2463)Att>Ctt	p.I821L	MYH10_ENST00000269243.4_Missense_Mutation_p.I790L|MYH10_ENST00000396239.1_Missense_Mutation_p.I811L|MYH10_ENST00000379980.4_Missense_Mutation_p.I806L	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	790					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						AAGAAGATAATGATATCGGTG	0.428000													45	95					0	0	0.870114	0	0
ELANE	1991	broad.mit.edu	37	19	852901	852901	+	Silent	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:852901G>T	ENST00000590230.1	+	3	234	c.93G>T	c.(91-93)gtG>gtT	p.V31V	ELANE_ENST00000263621.1_Silent_p.V31V			P08246	ELNE_HUMAN	elastase, neutrophil expressed	31	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CGGAGATTGTGGGGGGCCGGC	0.726000													8	4					0.000274275	0.000281652	0.307466	1	0
GAB4	128954	broad.mit.edu	37	22	17446137	17446137	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:17446137A>G	ENST00000400588.1	-	7	1417	c.1310T>C	c.(1309-1311)cTg>cCg	p.L437P		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	437										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GTTGTTTCTCAGGTTGGGCGG	0.547000													26	47					0	0	0.717897	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43696217	43696217	+	Silent	SNP	C	C	T	rs61758758	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:43696217C>T	ENST00000395809.1	-	5	3085	c.579G>A	c.(577-579)aaG>aaA	p.K193K	RASGEF1A_ENST00000395810.1_Silent_p.K193K|RASGEF1A_ENST00000374459.1_Silent_p.K201K|RASGEF1A_ENST00000472864.1_5'UTR			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	193					cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						GGATGGGCCCCTTGTCTACAG	0.642000													19	27					0	0	0.740014	0	0
CHD5	26038	broad.mit.edu	37	1	6211094	6211094	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:6211094C>A	ENST00000262450.3	-	7	1091	c.992G>T	c.(991-993)aGg>aTg	p.R331M	CHD5_ENST00000378021.1_De_novo_Start_InFrame	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	331					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGTCATACTCCTCTTCTTCTT	0.617000													19	22					1.10513e-12	1.17359e-12	0.624587	1	0
REV3L	5980	broad.mit.edu	37	6	111701250	111701250	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:111701250C>T	ENST00000435970.1	-	13	1971	c.1155G>A	c.(1153-1155)atG>atA	p.M385I	REV3L_ENST00000368802.3_Missense_Mutation_p.M463I|REV3L_ENST00000358835.3_Missense_Mutation_p.M463I|REV3L_ENST00000368805.1_Missense_Mutation_p.M463I			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	463					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AACTAAGCTCCATTTCCTCTT	0.348000								DNA polymerases (catalytic subunits)					114	290					0	0	0.870114	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708217	126708217	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:126708217C>T	ENST00000251772.4	+	1	781	c.712C>T	c.(712-714)Ctg>Ttg	p.L238L	PLXNA1_ENST00000393409.2_Silent_p.L261L			Q9UIW2	PLXA1_HUMAN	plexin A1	261	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CTACCTCACGCTGCAGCTAGA	0.562000													3	113					0	0	0.115264	0	0
DHX58	79132	broad.mit.edu	37	17	40263345	40263345	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:40263345G>A	ENST00000251642.3	-	4	561	c.339C>T	c.(337-339)agC>agT	p.S113S		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	113	Helicase ATP-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCTCCTCGGGGCTGGTCAGTG	0.632000													23	43					0	0	0.654019	0	0
DNAH2	146754	broad.mit.edu	37	17	7728027	7728027	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:7728027G>A	ENST00000572933.1	+	77	13295	c.11835G>A	c.(11833-11835)atG>atA	p.M3945I	DNAH2_ENST00000389173.2_Missense_Mutation_p.M3945I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3945	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCATCAAGATGACCACAGAGC	0.557000													9	127					0	0	0.335167	0	0
MYOM2	9172	broad.mit.edu	37	8	2005806	2005806	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:2005806C>A	ENST00000262113.4	+	5	609	c.468C>A	c.(466-468)atC>atA	p.I156I	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	156	Ig-like C2-type 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCCTGAGATCCTGGTGCGGC	0.597000													11	19					5.26018e-13	5.5931e-13	0.608945	1	0
OR3A1	4994	broad.mit.edu	37	17	3195465	3195465	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:3195465G>T	ENST00000323404.1	-	1	411	c.412C>A	c.(412-414)Cgc>Agc	p.R138S	RP11-64J4.2_ENST00000573491.1_RNA	NM_002550.2	NP_002541.2	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A, member 1	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	20						TGACTCATGCGGGTGCTGTAG	0.582000													48	104					3.16986e-14	3.37904e-14	0.870114	1	0
ESR1	2099	broad.mit.edu	37	6	152265601	152265601	+	Silent	SNP	A	A	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:152265601A>C	ENST00000440973.1	+	6	1424	c.1054A>C	c.(1054-1056)Agg>Cgg	p.R352R	ESR1_ENST00000443427.1_Silent_p.R352R|ESR1_ENST00000338799.5_Silent_p.R352R|ESR1_ENST00000544394.1_Silent_p.R179R|ESR1_ENST00000406599.1_Intron|ESR1_ENST00000206249.3_Silent_p.R352R|ESR1_ENST00000456483.2_Intron|ESR1_ENST00000482101.1_3'UTR	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	352	Interaction with AKAP13.|Steroid-binding.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CCTGGCAGACAGGGAGCTGGT	0.493000													12	145					0	0	0.457914	0	0
CACNA1F	778	broad.mit.edu	37	X	49071830	49071830	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:49071830T>C	ENST00000376265.2	-	28	3504	c.3443A>G	c.(3442-3444)tAc>tGc	p.Y1148C	CACNA1F_ENST00000376251.1_Missense_Mutation_p.Y1083C|CACNA1F_ENST00000323022.5_Missense_Mutation_p.Y1137C	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1148	Dihydropyridine binding (By similarity).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	ACAGTTTTGGTACTCCTGCTC	0.532000													3	39					0	0	0.184627	0	0
LEMD2	221496	broad.mit.edu	37	6	33744975	33744975	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:33744975G>A	ENST00000293760.5	-	7	1217	c.1198C>T	c.(1198-1200)Cgg>Tgg	p.R400W	LEMD2_ENST00000508327.1_Missense_Mutation_p.R98W|LEMD2_ENST00000502643.1_5'UTR	NM_181336.3	NP_851853.1	Q8NC56	LEMD2_HUMAN	LEM domain containing 2	400						integral to nuclear inner membrane				central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)|pancreas(1)	9						TTTCGCCACCGATATTTTAGG	0.488000													14	232					0	0	0.500413	0	0
KIF5A	3798	broad.mit.edu	37	12	57976896	57976896	+	Silent	SNP	G	G	A	rs148434838	byFrequency	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:57976896G>A	ENST00000455537.2	+	28	3307	c.3033G>A	c.(3031-3033)ccG>ccA	p.P1011P	KIF5A_ENST00000286452.5_Silent_p.P922P	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	1011	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						GTGACCTGCCGTGTGGCTATG	0.532000											OREG0021947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	32					0	0	0.435327	0	0
KNDC1	85442	broad.mit.edu	37	10	135013087	135013087	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:135013087C>T	ENST00000304613.3	+	15	2905	c.2884C>T	c.(2884-2886)Cag>Tag	p.Q962*	KNDC1_ENST00000368571.2_Nonsense_Mutation_p.Q897*|KNDC1_ENST00000368572.2_Nonsense_Mutation_p.Q964*			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	962					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGTCAACGGGCAGGCGTCACC	0.612000													31	71					0	0	0.760397	0	0
PHTF1	10745	broad.mit.edu	37	1	114243546	114243546	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:114243546A>G	ENST00000369604.1	-	16	2399	c.1916T>C	c.(1915-1917)cTg>cCg	p.L639P	PHTF1_ENST00000474926.1_5'UTR|PHTF1_ENST00000369596.2_Missense_Mutation_p.L586P|PHTF1_ENST00000393357.2_Missense_Mutation_p.L639P|PHTF1_ENST00000369600.1_Missense_Mutation_p.L586P|PHTF1_ENST00000369598.1_Missense_Mutation_p.L594P			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	639						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCATCATTCAGGAAAGTTTT	0.333000													42	42					0	0	0.870114	0	0
MXRA5	25878	broad.mit.edu	37	X	3235384	3235384	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:3235384G>A	ENST00000217939.6	-	6	6492	c.6338C>T	c.(6337-6339)gCg>gTg	p.A2113V		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2113	Ig-like C2-type 5.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCCTTGGGCGCGAGGTTGCG	0.667000													12	13					0	0	0.479597	0	0
CORO2B	10391	broad.mit.edu	37	15	69011755	69011755	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:69011755C>T	ENST00000543950.1	+	11	1514	c.1160C>T	c.(1159-1161)cCc>cTc	p.P387L	CORO2B_ENST00000261861.5_Missense_Mutation_p.P387L|CORO2B_ENST00000566799.1_Missense_Mutation_p.P392L|CORO2B_ENST00000540068.1_Missense_Mutation_p.P387L	NM_001190457.1	NP_001177386.1	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	392					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			kidney(3)|large_intestine(13)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TCTTTAGATCCCGTGCTGATG	0.478000													91	201					0	0	0.870114	0	0
EPHA5	2044	broad.mit.edu	37	4	66231674	66231674	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:66231674T>C	ENST00000273854.3	-	11	2626	c.2026A>G	c.(2026-2028)Acc>Gcc	p.T676A	EPHA5_ENST00000432638.2_Missense_Mutation_p.T513A|EPHA5_ENST00000354839.4_Missense_Mutation_p.T654A|EPHA5_ENST00000511294.1_Missense_Mutation_p.T677A	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	676	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTCTCAATGGTGATACATGAT	0.383000										TSP Lung(17;0.13)			89	73					0	0	0.870114	0	0
STK38L	23012	broad.mit.edu	37	12	27461270	27461270	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:27461270A>G	ENST00000389032.3	+	4	355		c.e4-1		STK38L_ENST00000539577.1_Intron	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like						intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					TTTTTTTAATAGAAAAAGTTA	0.338000													51	81					0	0	0.870114	0	0
CELSR2	1952	broad.mit.edu	37	1	109806260	109806260	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:109806260G>A	ENST00000271332.3	+	9	4923	c.4862G>A	c.(4861-4863)gGc>gAc	p.G1621D		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1621	Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CACTTCCTGGGCAGCAGCCTG	0.652000											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	41					0	0	0.870114	0	0
USP36	57602	broad.mit.edu	37	17	76794524	76794524	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:76794524G>A	ENST00000312010.6	-	20	3674	c.3350C>T	c.(3349-3351)gCc>gTc	p.A1117V	USP36_ENST00000542802.2_Missense_Mutation_p.A1117V|USP36_ENST00000449938.2_Missense_Mutation_p.A722V	NM_025090.3	NP_079366.3	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	1115					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			GCTGAGGCTGGCAGCCTTTGC	0.542000													4	87					0	0	0.150653	0	0
MTOR	2475	broad.mit.edu	37	1	11182163	11182163	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:11182163A>G	ENST00000361445.4	-	48	6759	c.6683T>C	c.(6682-6684)aTc>aCc	p.I2228T	MTOR_ENST00000376838.1_Missense_Mutation_p.I433T	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2228	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CGATAAAGGGATGACAGCGTA	0.537000													15	20					0	0	0.520397	0	0
PRKD3	23683	broad.mit.edu	37	2	37501708	37501708	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:37501708C>T	ENST00000379066.1	-	11	2269	c.1507G>A	c.(1507-1509)Gac>Aac	p.D503N	PRKD3_ENST00000234179.2_Missense_Mutation_p.D503N			O94806	KPCD3_HUMAN	protein kinase D3	503	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				TGAGAGCTGTCCCCATTGTTC	0.448000													8	167					0	0	0.278610	0	0
TEX15	56154	broad.mit.edu	37	8	30701622	30701622	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:30701622T>C	ENST00000256246.2	-	1	4986	c.4912A>G	c.(4912-4914)Aag>Gag	p.K1638E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1638										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGACAAACCTTAGTTTCTTCC	0.368000													7	130					0	0	0.248553	0	0
GCN1L1	10985	broad.mit.edu	37	12	120599736	120599736	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:120599736C>G	ENST00000300648.6	-	21	2302	c.2290G>C	c.(2290-2292)Gcc>Ccc	p.A764P		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	764					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCATAATGGCAAACTCCTCC	0.582000													33	90					0	0	0.760397	0	0
TREML4	285852	broad.mit.edu	37	6	41197850	41197850	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:41197850T>C	ENST00000341495.2	+	4	600	c.496T>C	c.(496-498)Tct>Cct	p.S166P	TREML4_ENST00000448827.2_Missense_Mutation_p.S166P	NM_198153.2	NP_937796.1	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid cells-like 4	166						extracellular region				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.196)					CATCAATGGCTCTGAGACCAG	0.547000													75	108					0	0	0.870114	0	0
EPPK1	83481	broad.mit.edu	37	8	144941154	144941154	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:144941154G>A	ENST00000525985.1	-	2	6339	c.6268C>T	c.(6268-6270)Cgg>Tgg	p.R2090W				P58107	EPIPL_HUMAN	epiplakin 1	2090						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGGAGTCCCGTGCAGCCTTG	0.597000													10	163					0	0	0.361761	0	0
DSC3	1825	broad.mit.edu	37	18	28598103	28598103	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:28598103A>G	ENST00000434452.1	-	9	1351	c.1197T>C	c.(1195-1197)aaT>aaC	p.N399N	DSC3_ENST00000360428.4_Silent_p.N399N	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	399	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GTCCATTTTCATTTCCCTTTA	0.303000													85	162					0	0	0.870114	0	0
GDF10	2662	broad.mit.edu	37	10	48429372	48429372	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:48429372G>A	ENST00000224605.2	-	2	779	c.514C>T	c.(514-516)Ctg>Ttg	p.L172L		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	172					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGGAAGAGCAGGTGCTGGCGT	0.741000													4	20					0	0	0.217242	0	0
SH3GL2	6456	broad.mit.edu	37	9	17787382	17787382	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:17787382A>G	ENST00000380607.4	+	5	456	c.336A>G	c.(334-336)ccA>ccG	p.P112P	SH3GL2_ENST00000537391.1_Silent_p.P65P	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	112	BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TCCTAGGCCCAGCACTTGGTG	0.468000													55	61					0	0	0.870114	0	0
GLO1	2739	broad.mit.edu	37	6	38652183	38652183	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:38652183G>A	ENST00000373365.4	-	3	361	c.275C>T	c.(274-276)gCg>gTg	p.A92V		NM_006708.2	NP_006699.2	Q04760	LGUL_HUMAN	glyoxalase I	92					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	6					Glutathione(DB00143)	TCTGGAGAGCGCCCAGGCTAT	0.303000													10	32					0	0	0.335167	0	0
TM2D2	83877	broad.mit.edu	37	8	38848862	38848862	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:38848862T>C	ENST00000412303.1	-	4	899	c.505A>G	c.(505-507)Act>Gct	p.T169A	TM2D2_ENST00000456845.2_Missense_Mutation_p.T169A|TM2D2_ENST00000456397.2_Missense_Mutation_p.T212A|TM2D2_ENST00000397070.2_Missense_Mutation_p.T169A	NM_001024380.1|NM_001024381.1|NM_031940.3	NP_001019551.1|NP_001019552.1|NP_114146.3	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2	212						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			TAGTAAACAGTGCACCAGTTG	0.483000													23	23					0	0	0.654019	0	0
TENM2	57451	broad.mit.edu	37	5	167654954	167654954	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:167654954A>G	ENST00000519204.1	+	24	5094	c.4976A>G	c.(4975-4977)tAt>tGt	p.Y1659C	TENM2_ENST00000520394.1_Missense_Mutation_p.Y1541C|TENM2_ENST00000518659.1_Missense_Mutation_p.Y1780C|TENM2_ENST00000545108.1_Missense_Mutation_p.Y1779C|TENM2_ENST00000403607.2_Missense_Mutation_p.Y1604C					teneurin transmembrane protein 2																		AGGGTGATGTATGCTAATGGG	0.517000													13	28					0	0	0.435327	0	0
ZNF221	7638	broad.mit.edu	37	19	44471168	44471168	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:44471168C>A	ENST00000251269.5	+	6	1842	c.1514C>A	c.(1513-1515)cCt>cAt	p.P505H	ZNF221_ENST00000592350.1_Missense_Mutation_p.P505H|ZNF221_ENST00000587682.1_Missense_Mutation_p.P505H	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GGGGAAAAACCTTTCAAATGT	0.443000													62	111					2.53126e-37	2.82372e-37	0.870114	1	0
NLRC5	84166	broad.mit.edu	37	16	57060873	57060873	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:57060873C>A	ENST00000436936.1	+	6	2243	c.2018C>A	c.(2017-2019)cCc>cAc	p.P673H	NLRC5_ENST00000262510.6_Missense_Mutation_p.P673H|NLRC5_ENST00000539144.1_Missense_Mutation_p.P673H|NLRC5_ENST00000308149.7_Missense_Mutation_p.P673H			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	673					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GATGGCTGTCCCCTGGAGCCC	0.597000													30	39					1.88708e-17	2.03485e-17	0.729181	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47612354	47612354	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:47612354G>A	ENST00000371917.4	+	23	3156	c.3156G>A	c.(3154-3156)caG>caA	p.Q1052Q		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1052					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ATAAAAGACAGATGGCCAGCT	0.433000													31	56					0	0	0.870114	0	0
C10orf137	26098	broad.mit.edu	37	10	127418872	127418872	+	Silent	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:127418872A>T	ENST00000337623.3	+	8	1035	c.930A>T	c.(928-930)ccA>ccT	p.P310P	C10orf137_ENST00000356792.4_Silent_p.P344P	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ACAACAAACCAATTAATGTGC	0.303000													79	149					0	0	0.870114	0	0
GPR149	344758	broad.mit.edu	37	3	154146817	154146817	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:154146817G>A	ENST00000389740.2	-	1	687	c.588C>T	c.(586-588)atC>atT	p.I196I		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	196						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAGCGTACACGATAGAGAGGA	0.642000													30	57					0	0	0.717897	0	0
ANKH	56172	broad.mit.edu	37	5	14713040	14713040	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:14713040G>A	ENST00000284268.6	-	11	1638	c.1308C>T	c.(1306-1308)ggC>ggT	p.G436G	ANKH_ENST00000535119.1_Silent_p.G238G	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	436					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CTCCCACAAAGCCCGCCAGGA	0.622000													12	21					0	0	0.479597	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67068486	67068486	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:67068486G>A	ENST00000447274.2	+	11	2013	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	ANKRD13D_ENST00000515828.1_Missense_Mutation_p.E17K|ANKRD13D_ENST00000511455.2_Missense_Mutation_p.E367K|ANKRD13D_ENST00000308440.6_Missense_Mutation_p.E280K|ANKRD13D_ENST00000514166.1_Missense_Mutation_p.E280K			Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	280										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GTGGCTGAGTGAAGAGCACCC	0.602000													17	22					0	0	0.520397	0	0
FAM178A	55719	broad.mit.edu	37	10	102676519	102676519	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:102676519A>G	ENST00000238961.3	+	3	525	c.377A>G	c.(376-378)cAt>cGt	p.H126R	FAM178A_ENST00000370269.3_Missense_Mutation_p.H126R|FAM178A_ENST00000370271.3_Missense_Mutation_p.H126R	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	126																	CATGAAGATCATGGTATACAT	0.408000													27	152					0	0	0.717897	0	0
MYL1	4632	broad.mit.edu	37	2	211159122	211159122	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:211159122C>G	ENST00000352451.3	-	4	472	c.325G>C	c.(325-327)Gag>Cag	p.E109Q	MYL1_ENST00000341685.4_Missense_Mutation_p.E65Q|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	109					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TGTTCAAACTCAATTTTCTTG	0.378000													57	107					0	0	0.870114	0	0
ETV1	2115	broad.mit.edu	37	7	13971309	13971309	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:13971309C>A	ENST00000343495.5	-	8	1304	c.566G>T	c.(565-567)gGa>gTa	p.G189V	ETV1_ENST00000405358.4_Missense_Mutation_p.G221V|ETV1_ENST00000405192.2_Missense_Mutation_p.G207V|ETV1_ENST00000420159.2_Missense_Mutation_p.G149V|ETV1_ENST00000403527.1_Missense_Mutation_p.G167V|ETV1_ENST00000476720.2_5'UTR|ETV1_ENST00000403685.1_Missense_Mutation_p.G189V|ETV1_ENST00000399357.3_Missense_Mutation_p.G104V|ETV1_ENST00000242066.5_Missense_Mutation_p.G189V|ETV1_ENST00000430479.1_Missense_Mutation_p.G207V|ETV1_ENST00000405218.2_Missense_Mutation_p.G207V			P50549	ETV1_HUMAN	ets variant 1	207					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						CATAGGACGTCCTTCCCTTGG	0.512000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								23	42					1.1804e-14	1.25989e-14	0.667858	1	0
TRPC4AP	26133	broad.mit.edu	37	20	33603887	33603887	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:33603887T>A	ENST00000252015.2	-	10	1363	c.1274A>T	c.(1273-1275)gAc>gTc	p.D425V	TRPC4AP_ENST00000432634.2_Missense_Mutation_p.D386V|TRPC4AP_ENST00000451813.1_Missense_Mutation_p.D417V|TRPC4AP_ENST00000539834.1_Missense_Mutation_p.D27V			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	425					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AATCAGTTTGTCAAACAAATT	0.458000													5	120					0	0	0.217242	0	0
ZNF544	27300	broad.mit.edu	37	19	58772838	58772838	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:58772838A>G	ENST00000269829.4	+	7	1340	c.866A>G	c.(865-867)aAg>aGg	p.K289R	CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000596825.1_3'UTR|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000596652.1_Missense_Mutation_p.K289R|ZNF544_ENST00000599953.1_Missense_Mutation_p.K147R|ZNF544_ENST00000600044.1_Missense_Mutation_p.K261R|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000595981.1_Intron|ZNF544_ENST00000415203.2_Missense_Mutation_p.K261R|ZNF544_ENST00000600220.1_Missense_Mutation_p.K261R	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AATGAACAGAAGCCAGTGCAT	0.428000													71	91					0	0	0.870114	0	0
KIF24	347240	broad.mit.edu	37	9	34257489	34257489	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:34257489C>T	ENST00000379166.2	-	11	2235	c.2116G>A	c.(2116-2118)Gtg>Atg	p.V706M	KIF24_ENST00000345050.2_Missense_Mutation_p.V572M|KIF24_ENST00000379174.3_Missense_Mutation_p.V572M|KIF24_ENST00000402558.2_Missense_Mutation_p.V706M	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	706					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			ACTGTCTGCACTTTCTTGCAC	0.552000													85	95					0	0	0.870114	0	0
GYS1	2997	broad.mit.edu	37	19	49490607	49490607	+	Silent	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:49490607A>T	ENST00000323798.3	-	3	532	c.336T>A	c.(334-336)ccT>ccA	p.P112P	GYS1_ENST00000263276.6_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000540532.1_Silent_p.P32P|GYS1_ENST00000541188.1_Silent_p.P32P|GYS1_ENST00000544287.1_Intron	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	112					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		GCACCACCAGAGGGCCTCCCT	0.627000													7	18					0	0	0.307466	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215693	20215693	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:20215693T>C	ENST00000331723.1	+	1	107	c.107T>C	c.(106-108)aTt>aCt	p.I36T		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTTTTTACATTGCTATTGTC	0.383000													221	96					0	0	0.870114	0	0
AGBL1	123624	broad.mit.edu	37	15	86806023	86806023	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:86806023A>G	ENST00000441037.2	+	9	941	c.846A>G	c.(844-846)gaA>gaG	p.E282E	AGBL1_ENST00000389298.3_Silent_p.E13E|AGBL1_ENST00000421325.2_Silent_p.E282E	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	282	Asp-rich.				C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						ATGACTTGGAAACAGACGTGA	0.428000													10	28					0	0	0.387290	0	0
OR4S2	219431	broad.mit.edu	37	11	55418395	55418395	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:55418395A>G	ENST00000312422.2	+	1	16	c.16A>G	c.(16-18)Aac>Gac	p.N6D		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				AAAAATAAACAACGTAACTGA	0.323000													70	27					0	0	0.870114	0	0
MUC6	4588	broad.mit.edu	37	11	1028224	1028224	+	Splice_Site	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:1028224A>G	ENST00000421673.2	-	14	1804		c.e14+1			NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming						maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGGACACTCACTGTTGAGCT	0.697000													3	2					0	0	0.115264	0	0
SLC38A11	151258	broad.mit.edu	37	2	165768159	165768159	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:165768159A>G	ENST00000303735.4	-	8	1046	c.716T>C	c.(715-717)tTt>tCt	p.F239S	SLC38A11_ENST00000409058.1_Missense_Mutation_p.F292S|SLC38A11_ENST00000409149.3_Missense_Mutation_p.F261S|SLC38A11_ENST00000409662.1_Missense_Mutation_p.F261S	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	261					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						TCTTGTCACAAAGCATTCCAT	0.393000													6	81					0	0	0.248553	0	0
TMCC3	57458	broad.mit.edu	37	12	94975436	94975436	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:94975436A>G	ENST00000261226.4	-	2	1088	c.957T>C	c.(955-957)taT>taC	p.Y319Y	TMCC3_ENST00000551457.1_Silent_p.Y288Y	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	319						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						AAATAAAACCATATTCTCTCT	0.393000													18	115					0	0	0.624587	0	0
KCTD9	54793	broad.mit.edu	37	8	25290134	25290134	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:25290134C>A	ENST00000221200.4	-	11	1159	c.939G>T	c.(937-939)gtG>gtT	p.V313V		NM_017634.3	NP_060104.2	Q7L273	KCTD9_HUMAN	potassium channel tetramerization domain containing 9	313	Pentapeptide repeat 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(2)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)	12		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		CTTCCATATCCACACCTTTCA	0.393000													9	360					7.03913e-09	7.37265e-09	0.411799	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176930	140176930	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:140176930T>C	ENST00000526136.1	+	1	2381	c.2381T>C	c.(2380-2382)gTa>gCa	p.V794A	PCDHA2_ENST00000378132.1_Missense_Mutation_p.V794A|PCDHA2_ENST00000520672.2_Missense_Mutation_p.V794A|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGAATACGTAGGAAAGGTG	0.403000													33	78					0	0	0.750413	0	0
GUCY2F	2986	broad.mit.edu	37	X	108631735	108631735	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:108631735C>A	ENST00000218006.2	-	15	3230	c.2939G>T	c.(2938-2940)cGa>cTa	p.R980L		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	980	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						AAGGCCAATTCGAATTCGGAC	0.453000													117	113					2.98776e-44	3.34629e-44	0.870114	1	0
DENND4A	10260	broad.mit.edu	37	15	65962172	65962172	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:65962172C>T	ENST00000443035.3	-	27	4944	c.4729G>A	c.(4729-4731)Gcc>Acc	p.A1577T	DENND4A_ENST00000431932.2_Missense_Mutation_p.A1534T	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1534					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						AGACCAGAGGCTGATGTTGAA	0.358000													6	52					0	0	0.217242	0	0
UBR5	51366	broad.mit.edu	37	8	103372381	103372381	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:103372381A>G	ENST00000520539.1	-	5	910	c.304T>C	c.(304-306)Tca>Cca	p.S102P	UBR5_ENST00000521922.1_Missense_Mutation_p.S102P|UBR5_ENST00000220959.4_Missense_Mutation_p.S102P	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	102					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCAGGCCTTGACGTCCTCCCT	0.493000													3	106					0	0	0.115264	0	0
ZBTB4	57659	broad.mit.edu	37	17	7365705	7365705	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:7365705T>C	ENST00000311403.4	-	4	2935	c.2596A>G	c.(2596-2598)Agc>Ggc	p.S866G	ZBTB4_ENST00000380599.4_Missense_Mutation_p.S866G	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	866					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TATACATAGCTGCCCCCGCTT	0.622000													13	29					0	0	0.479597	0	0
NELL1	4745	broad.mit.edu	37	11	20691274	20691274	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:20691274C>A	ENST00000298925.5	+	1	158	c.5C>A	c.(4-6)cCg>cAg	p.P2Q	NELL1_ENST00000325319.5_Missense_Mutation_p.P2Q|NELL1_ENST00000532434.1_Missense_Mutation_p.P2Q|NELL1_ENST00000357134.5_Missense_Mutation_p.P2Q			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	2					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AGAGCGATGCCGATGGATTTG	0.597000													16	36					3.32936e-07	3.46122e-07	0.539581	1	0
EXT1	2131	broad.mit.edu	37	8	119122871	119122871	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:119122871C>A	ENST00000378204.2	-	1	1221	c.415G>T	c.(415-417)Gag>Tag	p.E139*		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	139					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CTGGAGCCCTCGATGGCCGCT	0.498000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				67	108					4.13886e-29	4.57453e-29	0.870114	1	0
ATP10A	57194	broad.mit.edu	37	15	25966975	25966975	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:25966975A>G	ENST00000356865.6	-	7	1303	c.1192T>C	c.(1192-1194)Ttg>Ctg	p.L398L		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	398					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCGTCATACAACTGCATGTCC	0.428000													59	134					0	0	0.870114	0	0
KRR1	11103	broad.mit.edu	37	12	75900592	75900592	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:75900592T>G	ENST00000229214.4	-	3	386	c.363A>C	c.(361-363)aaA>aaC	p.K121N	KRR1_ENST00000438169.2_Missense_Mutation_p.K121N	NM_007043.6	NP_008974.5	Q13601	KRR1_HUMAN	KRR1, small subunit (SSU) processome component, homolog (yeast)	121					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						TTGCTAACAGTTTTATCAGAT	0.383000													75	118					0	0	0.870114	0	0
UCN3	114131	broad.mit.edu	37	10	5415994	5415994	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:5415994G>T	ENST00000380433.3	+	2	539	c.311G>T	c.(310-312)aGg>aTg	p.R104M		NM_053049.2	NP_444277.2	Q969E3	UCN3_HUMAN	urocortin 3	104						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						GCACAGCCCAGGGGAAAGCCA	0.602000													10	10					1.58986e-06	1.64671e-06	0.361761	1	0
REV3L	5980	broad.mit.edu	37	6	111688861	111688861	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:111688861C>A	ENST00000435970.1	-	16	6712	c.5896G>T	c.(5896-5898)Gat>Tat	p.D1966Y	REV3L_ENST00000368802.3_Missense_Mutation_p.D2044Y|REV3L_ENST00000358835.3_Missense_Mutation_p.D2044Y|REV3L_ENST00000368805.1_Missense_Mutation_p.D2044Y			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2044					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GGTTTGTCATCTGGGTTAACT	0.413000								DNA polymerases (catalytic subunits)					105	212					2.12868e-59	2.40012e-59	0.870114	1	0
KBTBD6	89890	broad.mit.edu	37	13	41705364	41705364	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:41705364C>A	ENST00000379485.1	-	1	1518	c.1284G>T	c.(1282-1284)atG>atT	p.M428I	KBTBD6_ENST00000499385.2_Missense_Mutation_p.M362I	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	428							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATGCCACATCCATGCCCTCAC	0.473000													56	133					2.43277e-16	2.61321e-16	0.870114	1	0
GRK4	2868	broad.mit.edu	37	4	3015545	3015545	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:3015545G>A	ENST00000398052.4	+	8	1074	c.731G>A	c.(730-732)aGt>aAt	p.S244N	GRK4_ENST00000345167.6_Missense_Mutation_p.S212N|GRK4_ENST00000398051.4_Missense_Mutation_p.S212N|GRK4_ENST00000504933.1_Missense_Mutation_p.S244N	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	244	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAAGTGCAAAGTAGATTCGTA	0.398000													5	102					0	0	0.184627	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775451	77775451	+	Silent	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:77775451T>A	ENST00000521891.2	+	11	9949	c.9501T>A	c.(9499-9501)ccT>ccA	p.P3167P	ZFHX4_ENST00000455469.2_Silent_p.P3122P|ZFHX4_ENST00000050961.6_Silent_p.P3118P|ZFHX4_ENST00000518282.1_Silent_p.P3141P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3118						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ctccaccacctcctcctcctc	0.522000										HNSCC(33;0.089)			5	8					0	0	0.217242	0	0
PTPRA	5786	broad.mit.edu	37	20	3002826	3002826	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:3002826T>C	ENST00000216877.6	+	14	1661	c.1261T>C	c.(1261-1263)Tgt>Cgt	p.C421R	PTPRA_ENST00000399903.2_Missense_Mutation_p.C430R|PTPRA_ENST00000318266.5_Missense_Mutation_p.C421R|PTPRA_ENST00000425918.2_Missense_Mutation_p.C441R|PTPRA_ENST00000380393.3_Missense_Mutation_p.C430R|PTPRA_ENST00000358719.4_Missense_Mutation_p.C286R|PTPRA_ENST00000356147.3_Missense_Mutation_p.C421R	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	430	Tyrosine-protein phosphatase 1.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGTGAAGGCCTGTAACCCTCA	0.587000													48	127					0	0	0.870114	0	0
GLA	2717	broad.mit.edu	37	X	100656700	100656700	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:100656700G>A	ENST00000218516.3	-	3	488	c.467C>T	c.(466-468)gCc>gTc	p.A156V	RPL36A-HNRNPH2_ENST00000409170.3_Intron|GLA_ENST00000493905.1_5'UTR	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	156			A -> T (in FD; dbSNP:rs28935195).|A -> V (in FD).		glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	AAAGGTCTGGGCATCAATGTC	0.438000													5	210					0	0	0.184627	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36927421	36927421	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:36927421G>A	ENST00000269554.3	-	8	1392	c.912C>T	c.(910-912)gaC>gaT	p.D304D		NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	304	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						CACActcctcgtcctctgccc	0.607000													13	40					0	0	0.479597	0	0
TNXB	7148	broad.mit.edu	37	6	32017812	32017812	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:32017812G>A	ENST00000375244.3	-	27	9603	c.9402C>T	c.(9400-9402)ggC>ggT	p.G3134G	TNXB_ENST00000375247.2_Silent_p.G3132G			P22105	TENX_HUMAN	tenascin XB	3179	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTACGCGCTGGCCACCGTGGA	0.637000													13	33					0	0	0.557998	0	0
CCDC88B	283234	broad.mit.edu	37	11	64108789	64108789	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:64108789G>A	ENST00000356786.5	+	5	480	c.436G>A	c.(436-438)Gcg>Acg	p.A146T	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	146					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACTGTTGGGAGCGTCAGTACA	0.602000													28	70					0	0	0.750413	0	0
TAF9B	51616	broad.mit.edu	37	X	77387115	77387115	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:77387115T>C	ENST00000341864.5	-	7	842	c.748A>G	c.(748-750)Att>Gtt	p.I250V		NM_015975.4	NP_057059.2	Q9HBM6	TAF9B_HUMAN	TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa	250					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	14						CCTTACATAATATCATTGTCA	0.343000													4	199					0	0	0.184627	0	0
AJUBA	84962	broad.mit.edu	37	14	23445902	23445902	+	Translation_Start_Site	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:23445902C>A	ENST00000397388.3	-	0	530				AJUBA_ENST00000262713.2_Missense_Mutation_p.K376N|RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000361265.4_Missense_Mutation_p.K376N	NM_198086.1	NP_932352.1	Q96IF1	JUB_HUMAN	ajuba LIM protein						cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										TGTAGAAAGCCTTGCAACGCA	0.527000													153	63					2.92728e-61	3.305e-61	0.870114	1	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100502181	100502181	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:100502181T>C	ENST00000279907.7	-	2	402	c.190A>G	c.(190-192)Aat>Gat	p.N64D	UHRF1BP1L_ENST00000356828.3_Missense_Mutation_p.N64D	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	64										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						GACGCTTTATTACAAAAAACT	0.363000													70	119					0	0	0.870114	0	0
VASP	7408	broad.mit.edu	37	19	46021017	46021017	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:46021017C>T	ENST00000245932.6	+	2	458	c.102C>T	c.(100-102)agC>agT	p.S34S	VASP_ENST00000586619.1_3'UTR	NM_003370.3	NP_003361.1	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	34	WH1.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)	18		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		AGGCCTTCAGCCGCGTCCAGA	0.642000													4	67					0	0	0.150653	0	0
KCNA1	3736	broad.mit.edu	37	12	5020549	5020549	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:5020549C>T	ENST00000382545.3	+	2	1112	c.5C>T	c.(4-6)aCg>aTg	p.T2M	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	2					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCCACCATGACGGTGATGTCT	0.741000													10	19					0	0	0.411799	0	0
WNK2	65268	broad.mit.edu	37	9	96051602	96051602	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:96051602C>T	ENST00000297954.4	+	20	4677	c.4677C>T	c.(4675-4677)acC>acT	p.T1559T	WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Silent_p.T1134T|WNK2_ENST00000349097.3_Silent_p.T1171T|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000395477.2_Silent_p.T1522T			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1559					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGGGGCCCACCGTCCCCCCAC	0.711000													7	2					0	0	0.307466	0	0
MARCH8	220972	broad.mit.edu	37	10	45953840	45953840	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:45953840A>G	ENST00000453424.2	-	8	1830	c.1569T>C	c.(1567-1569)tgT>tgC	p.C523C	MARCH8_ENST00000395771.3_Silent_p.C241C|MARCH8_ENST00000476962.1_5'UTR|MARCH8_ENST00000395769.2_Silent_p.C241C|MARCH8_ENST00000319836.3_Silent_p.C241C			Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	241						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						TTGTTTCTGGACAGTTTTGAA	0.358000													80	226					0	0	0.870114	0	0
LRIG3	121227	broad.mit.edu	37	12	59274640	59274640	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:59274640C>T	ENST00000320743.3	-	13	1810	c.1524G>A	c.(1522-1524)caG>caA	p.Q508Q	LRIG3_ENST00000379141.4_Silent_p.Q448Q	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	508	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TTATTGCCGACTGTGTTTCTG	0.428000			T	ROS1	NSCLC								109	221					0	0	0.870114	0	0
POLG2	11232	broad.mit.edu	37	17	62487033	62487033	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:62487033G>A	ENST00000539111.2	-	4	916	c.849C>T	c.(847-849)ggC>ggT	p.G283G		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	283					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			TTCCTTTCCGGCCTTCTTCAT	0.383000													5	207					0	0	0.217242	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111935618	111935618	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:111935618C>A	ENST00000375741.2	+	17	2171	c.1921C>A	c.(1921-1923)Ctg>Atg	p.L641M	ARHGEF7_ENST00000375736.4_Missense_Mutation_p.L463M|ARHGEF7_ENST00000478679.1_Missense_Mutation_p.L385M|ARHGEF7_ENST00000375739.2_Missense_Mutation_p.L591M|ARHGEF7_ENST00000370623.3_Missense_Mutation_p.L548M|ARHGEF7_ENST00000317133.5_Missense_Mutation_p.L620M|ARHGEF7_ENST00000544132.1_3'UTR|ARHGEF7_ENST00000218789.5_Missense_Mutation_p.L463M|ARHGEF7_ENST00000426073.2_Missense_Mutation_p.L463M|ARHGEF7_ENST00000375737.5_Missense_Mutation_p.L538M|ARHGEF7_ENST00000375723.1_Missense_Mutation_p.L463M	NM_001113511.1|NM_145735.2	NP_001106983.1|NP_663788.1	Q14155	ARHG7_HUMAN	Rho guanine nucleotide exchange factor (GEF) 7	641					apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	41	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			CTGGGGACCCCTGGAGCCTCC	0.706000													5	6					3.59834e-05	3.71784e-05	0.217242	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367814	145367814	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:145367814A>G	ENST00000342960.5	+	83	10445	c.10410A>G	c.(10408-10410)ccA>ccG	p.P3470P	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3470										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAAACCCACCATGCCCCAGGT	0.428000													37	80					0	0	0.827153	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182200	57182200	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:57182200G>A	ENST00000504228.1	+	6	2637	c.2532G>A	c.(2530-2532)ccG>ccA	p.P844P	KIAA1211_ENST00000264229.6_Silent_p.P844P|KIAA1211_ENST00000541073.1_Silent_p.P837P			Q6ZU35	K1211_HUMAN	KIAA1211	844										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AAGCCTCACCGTTTGGAATAA	0.527000													18	15					0	0	0.592651	0	0
ZFPM2	23414	broad.mit.edu	37	8	106646501	106646501	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:106646501C>T	ENST00000407775.2	+	5	698	c.448C>T	c.(448-450)Ctg>Ttg	p.L150L	ZFPM2_ENST00000517361.1_Silent_p.L18L|ZFPM2_ENST00000520492.1_Silent_p.L18L	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	150					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCCAATGGTGCTGACTGCTGG	0.408000													11	17					0	0	0.457914	0	0
BAZ2B	29994	broad.mit.edu	37	2	160295144	160295144	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:160295144C>A	ENST00000392783.2	-	8	1458	c.963G>T	c.(961-963)caG>caT	p.Q321H	BAZ2B_ENST00000392782.1_Missense_Mutation_p.Q319H|BAZ2B_ENST00000355831.2_Missense_Mutation_p.Q321H|BAZ2B_ENST00000343439.5_Missense_Mutation_p.Q319H	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TTCTTTTTTCCTGGGCTTTTT	0.423000													82	188					4.75426e-39	5.31768e-39	0.870114	1	0
MET	4233	broad.mit.edu	37	7	116371797	116371797	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:116371797C>T	ENST00000397752.3	+	3	1476	c.1276C>T	c.(1276-1278)Cgc>Tgc	p.R426C	MET_ENST00000436117.2_Missense_Mutation_p.R426C|MET_ENST00000318493.6_Missense_Mutation_p.R426C|MET_ENST00000495962.1_3'UTR	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	426	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AGCTTTGCAGCGCGTTGACTT	0.428000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				5	119					0	0	0.184627	0	0
ITIH2	3698	broad.mit.edu	37	10	7777015	7777015	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:7777015C>T	ENST00000358415.4	+	15	2084	c.1918C>T	c.(1918-1920)Ctg>Ttg	p.L640L	ITIH2_ENST00000379587.4_Silent_p.L629L	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	640					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TGAGCGCATGCTGGCGGATGC	0.617000													3	26					0	0	0.115264	0	0
GAPDHS	26330	broad.mit.edu	37	19	36029483	36029483	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:36029483A>G	ENST00000222286.4	+	4	463	c.347A>G	c.(346-348)tAc>tGc	p.Y116C		NM_014364.4	NP_055179.1	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	116					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)	11	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	CCACAGGTGTACATGTTTAAG	0.522000													10	22					0	0	0.361761	0	0
RNF19A	25897	broad.mit.edu	37	8	101299911	101299911	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:101299911C>T	ENST00000519449.1	-	3	808	c.492G>A	c.(490-492)agG>agA	p.R164R	RNF19A_ENST00000341084.2_Silent_p.R164R	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	164					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AGATTTCTATCCTTAAATATT	0.373000													81	196					0	0	0.870114	0	0
RHCG	51458	broad.mit.edu	37	15	90021181	90021181	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:90021181C>T	ENST00000268122.4	-	6	930	c.862G>A	c.(862-864)Gca>Aca	p.A288T	RHCG_ENST00000544600.1_Missense_Mutation_p.A288T	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	288					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					ACCCCTCCTGCGAGCGTGGCA	0.632000													23	41					0	0	0.639603	0	0
OR10G8	219869	broad.mit.edu	37	11	123900597	123900597	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123900597G>A	ENST00000431524.1	+	1	301	c.268G>A	c.(268-270)Gct>Act	p.A90T		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AAGTGGCAGGGCTATCTCCTT	0.512000													15	95					0	0	0.812448	0	0
CCDC54	84692	broad.mit.edu	37	3	107096890	107096890	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:107096890A>G	ENST00000261058.1	+	1	703	c.456A>G	c.(454-456)atA>atG	p.I152M		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	152										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						GCTCCACGATACATTGTCTAG	0.403000													38	90					0	0	0.812448	0	0
ANK3	288	broad.mit.edu	37	10	61967865	61967865	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:61967865C>T	ENST00000280772.1	-	10	1314	c.1123G>A	c.(1123-1125)Gcc>Acc	p.A375T	ANK3_ENST00000373827.2_Missense_Mutation_p.A369T|ANK3_ENST00000503366.1_Missense_Mutation_p.A358T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	375					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCACAGTGGGCAGCCACGTGT	0.522000													28	57					0	0	0.796494	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14846	14846	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrM:14846G>A	ENST00000361789.2	+	1	100	c.100G>A	c.(100-102)Ggc>Agc	p.34_34insS						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						GATGAAACTTCGGCTCACTCC	0.483000													7	0					0	0	0.278610	0	0
OLAH	55301	broad.mit.edu	37	10	15113840	15113840	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:15113840T>A	ENST00000378217.3	+	8	965	c.778T>A	c.(778-780)Ttt>Att	p.F260I	OLAH_ENST00000378228.3_Missense_Mutation_p.F207I|OLAH_ENST00000485251.1_Intron	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	207					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						CTTGACATGTTTTGTTGGATC	0.328000													98	180					0	0	0.870114	0	0
MYLK4	340156	broad.mit.edu	37	6	2689172	2689172	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:2689172G>A	ENST00000274643.7	-	4	596	c.254C>T	c.(253-255)cCg>cTg	p.P85L	MYLK4_ENST00000268446.5_Missense_Mutation_p.P85L	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	85							ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				AAATGGGGCCGGAGGAGCCGG	0.502000													5	306					0	0	0.184627	0	0
APOB	338	broad.mit.edu	37	2	21233356	21233356	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:21233356T>C	ENST00000233242.1	-	26	6511	c.6384A>G	c.(6382-6384)tcA>tcG	p.S2128S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2128	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCCAATTGAATGAATTCAGAT	0.358000													31	82					0	0	0.760397	0	0
ASB10	136371	broad.mit.edu	37	7	150883716	150883716	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:150883716A>G	ENST00000422024.1	-	2	607	c.482T>C	c.(481-483)cTg>cCg	p.L161P	ASB10_ENST00000275838.1_Missense_Mutation_p.L116P|ASB10_ENST00000434669.1_Missense_Mutation_p.L161P|ASB10_ENST00000420175.2_Missense_Mutation_p.L116P|ASB10_ENST00000377867.3_Missense_Mutation_p.L101P	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	116					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGTGGTCAGCTCCTCTTC	0.662000													3	16					0	0	0.115264	0	0
BSCL2	26580	broad.mit.edu	37	11	62462149	62462149	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:62462149A>G	ENST00000433053.1	-	5	1077	c.521T>C	c.(520-522)tTa>tCa	p.L174S	BSCL2_ENST00000405837.1_Missense_Mutation_p.L174S|BSCL2_ENST00000537604.1_5'UTR|BSCL2_ENST00000278893.7_Missense_Mutation_p.L110S|BSCL2_ENST00000421906.1_Missense_Mutation_p.L110S|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000360796.5_Missense_Mutation_p.L174S|BSCL2_ENST00000403550.1_Missense_Mutation_p.L110S|BSCL2_ENST00000407022.3_Missense_Mutation_p.L110S			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	110					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						CTCAAGCTCTAAGGTAACACG	0.448000											OREG0021029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					0	0	0.624587	0	0
VWF	7450	broad.mit.edu	37	12	6122671	6122671	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:6122671A>G	ENST00000261405.5	-	32	5850	c.5596T>C	c.(5596-5598)Tcc>Ccc	p.S1866P		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1866	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGGAGGAAGGAATTGCCCAAG	0.483000													9	148					0	0	0.307466	0	0
PAG1	55824	broad.mit.edu	37	8	81897572	81897572	+	Silent	SNP	G	G	A	rs113484085		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:81897572G>A	ENST00000220597.4	-	7	1025	c.315C>T	c.(313-315)taC>taT	p.Y105Y		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	105					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GGACTTCCTCGTAATGCTGCA	0.498000													21	38					0	0	0.639603	0	0
ITGAX	3687	broad.mit.edu	37	16	31374511	31374511	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:31374511T>C	ENST00000268296.4	+	14	1647	c.1526T>C	c.(1525-1527)gTt>gCt	p.V509A	ITGAX_ENST00000562522.1_Missense_Mutation_p.V509A	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	509					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TGTGATGCTGTTCTCTACGGG	0.642000													61	146					0	0	0.870114	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996082	19996082	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:19996082C>T	ENST00000391403.2	-	1	1796	c.1693G>A	c.(1693-1695)Gca>Aca	p.A565T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	565						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CACGGAGGTGCCAGGGGCCCA	0.498000													36	80					0	0	0.812448	0	0
HECW2	57520	broad.mit.edu	37	2	197092917	197092917	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:197092917G>T	ENST00000260983.2	-	22	4008	c.3826C>A	c.(3826-3828)Cca>Aca	p.P1276T	HECW2_ENST00000409111.1_Missense_Mutation_p.P920T	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	1276	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CCATAATATGGGTTAAAGAGT	0.353000													43	84					6.2361e-21	6.82074e-21	0.834066	1	0
HNRNPUL2	221092	broad.mit.edu	37	11	62489666	62489666	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:62489666A>G	ENST00000301785.5	-	7	1474	c.1282T>C	c.(1282-1284)Ttt>Ctt	p.F428L	RP11-831H9.16_ENST00000403734.2_Missense_Mutation_p.F428L	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	428					cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						ATGAACACAAACTCTTCTGGT	0.502000													3	182					0	0	0.115264	0	0
ZFHX3	463	broad.mit.edu	37	16	72993580	72993580	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:72993580G>A	ENST00000268489.5	-	2	1137	c.465C>T	c.(463-465)ggC>ggT	p.G155G	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	155					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TCCCACAGGCGCCCCCGCCCT	0.672000													16	37					0	0	0.608945	0	0
KIF13B	23303	broad.mit.edu	37	8	28967545	28967545	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:28967545C>T	ENST00000524189.1	-	33	4011	c.3973G>A	c.(3973-3975)Gca>Aca	p.A1325T		NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1325					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		ACATTGGCTGCCATTCTTGCT	0.463000													4	6					0	0	0.184627	0	0
SOGA2	23255	broad.mit.edu	37	18	8793021	8793021	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:8793021A>T	ENST00000359865.3	+	8	2055	c.1913A>T	c.(1912-1914)gAg>gTg	p.E638V	SOGA2_ENST00000517570.1_Intron|SOGA2_ENST00000306329.11_Intron|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Intron|SOGA2_ENST00000518815.1_Intron	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	980																	GTTTTACCTGAGCAGAGTGTA	0.527000													65	107					0	0	0.870114	0	0
ENPP7	339221	broad.mit.edu	37	17	77710966	77710966	+	Missense_Mutation	SNP	G	G	A	rs140556423		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:77710966G>A	ENST00000328313.5	+	4	1374	c.1153G>A	c.(1153-1155)Gtc>Atc	p.V385I		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	385					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTTTGAGAGCGTCCACGTGTA	0.627000													26	28					0	0	0.667858	0	0
STX11	8676	broad.mit.edu	37	6	144508482	144508482	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:144508482G>A	ENST00000367568.4	+	2	901	c.718G>A	c.(718-720)Gac>Aac	p.D240N		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	240	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GAAGCAGGCCGACACCCTGAA	0.627000									Familial Hemophagocytic Lymphohistiocytosis				12	30					0	0	0.387290	0	0
MYH4	4622	broad.mit.edu	37	17	10348583	10348583	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:10348583C>A	ENST00000255381.2	-	36	5376	c.5266G>T	c.(5266-5268)Gag>Tag	p.E1756*	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1756					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GCCTTCTCCTCTGCATTGCGG	0.468000													16	249					3.32936e-07	3.46122e-07	0.539581	1	0
LUZP2	338645	broad.mit.edu	37	11	24518815	24518815	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:24518815T>C	ENST00000336930.6	+	1	92	c.26T>C	c.(25-27)cTg>cCg	p.L9P	LUZP2_ENST00000531187.1_3'UTR|LUZP2_ENST00000533227.1_5'UTR			Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	9						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						GCGCACTACCTGCTGCCTCTC	0.652000													6	16					0	0	0.361761	0	0
PHYHIP	9796	broad.mit.edu	37	8	22078925	22078925	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:22078925T>C	ENST00000454243.2	-	5	1508	c.934A>G	c.(934-936)Act>Gct	p.T312A	PHYHIP_ENST00000321613.3_Missense_Mutation_p.T312A	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	312										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GCATCGGCAGTAGACAGACTC	0.637000													21	50					0	0	0.729181	0	0
DPP3	10072	broad.mit.edu	37	11	66262690	66262690	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:66262690C>T	ENST00000532677.1	+	13	1861	c.1460C>T	c.(1459-1461)gCa>gTa	p.A487V	DPP3_ENST00000541961.1_Missense_Mutation_p.A468V|DPP3_ENST00000453114.1_Missense_Mutation_p.A468V|DPP3_ENST00000530165.1_Missense_Mutation_p.A438V|DPP3_ENST00000533799.1_3'UTR|DPP3_ENST00000360510.2_Missense_Mutation_p.A468V|DPP3_ENST00000531863.1_Missense_Mutation_p.A488V	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	468					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						GAAAAAGGAGCATTCAACTTT	0.612000													25	62					0	0	0.717897	0	0
ABCC4	10257	broad.mit.edu	37	13	95822853	95822853	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:95822853A>G	ENST00000376887.4	-	14	1871	c.1757T>C	c.(1756-1758)aTc>aCc	p.I586T	ABCC4_ENST00000536256.1_Missense_Mutation_p.I511T|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000431522.1_Missense_Mutation_p.I586T|ABCC4_ENST00000412704.1_Missense_Mutation_p.I586T	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	586	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TAAAATTGTGATCTTCTCATG	0.368000													23	45					0	0	0.681144	0	0
ILF3	3609	broad.mit.edu	37	19	10787852	10787852	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:10787852A>G	ENST00000449870.1	+	5	742	c.425A>G	c.(424-426)gAc>gGc	p.D142G	ILF3_ENST00000420083.1_Missense_Mutation_p.D142G|ILF3_ENST00000588657.1_Missense_Mutation_p.D142G|ILF3_ENST00000589998.1_Missense_Mutation_p.D142G|ILF3_ENST00000250241.8_Missense_Mutation_p.D142G|ILF3_ENST00000592763.1_Missense_Mutation_p.D142G|ILF3_ENST00000318511.3_Missense_Mutation_p.D142G|ILF3_ENST00000590261.1_Missense_Mutation_p.D142G|ILF3_ENST00000407004.3_Missense_Mutation_p.D142G	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	142	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GTAACAGAAGACAAGTACGAA	0.403000													8	185					0	0	0.307466	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39425422	39425422	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:39425422A>G	ENST00000216099.7	+	5	1067	c.660A>G	c.(658-660)ctA>ctG	p.L220L	APOBEC3D_ENST00000381568.4_Silent_p.L220L|APOBEC3D_ENST00000427494.2_Intron	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	220					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					TTAAAAACCTACTGAAAGCCT	0.512000													51	45					0	0	0.870114	0	0
ARID1B	57492	broad.mit.edu	37	6	157521896	157521896	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:157521896G>A	ENST00000346085.5	+	18	4169	c.4168G>A	c.(4168-4170)Gac>Aac	p.D1390N	ARID1B_ENST00000350026.5_Missense_Mutation_p.D1377N|ARID1B_ENST00000275248.4_Missense_Mutation_p.D1372N|ARID1B_ENST00000367148.1_Missense_Mutation_p.D1430N	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1377					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCACGAGGGCGACATGTACAA	0.557000													5	119					0	0	0.217242	0	0
G3BP1	10146	broad.mit.edu	37	5	151183518	151183518	+	Nonsense_Mutation	SNP	C	C	T	rs140218237		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:151183518C>T	ENST00000394123.3	+	12	1412	c.1267C>T	c.(1267-1269)Cga>Tga	p.R423*	G3BP1_ENST00000543466.1_Nonsense_Mutation_p.R241*|G3BP1_ENST00000356245.3_Nonsense_Mutation_p.R423*			Q13283	G3BP1_HUMAN	GTPase activating protein (SH3 domain) binding protein 1	423					Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding	p.R423*(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|skin(3)|urinary_tract(2)	29		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GGAAGGCGACCGACGAGATAA	0.572000													51	97					0	0	0.870114	0	0
ARRB1	408	broad.mit.edu	37	11	74985123	74985123	+	Silent	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:74985123G>A	ENST00000420843.2	-	11	1006	c.909C>T	c.(907-909)agC>agT	p.S303S	ARRB1_ENST00000393505.4_Silent_p.S303S|ARRB1_ENST00000360025.3_Silent_p.S303S	NM_004041.4	NP_004032.2	P49407	ARRB1_HUMAN	arrestin, beta 1	303					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(4)|large_intestine(2)|lung(4)|prostate(1)	11						CTCACAGGGTGCTAGAGGCCA	0.602000													19	245					0	0	0.557998	0	0
EIF4A3	9775	broad.mit.edu	37	17	78113889	78113889	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:78113889A>G	ENST00000269349.3	-	5	644	c.423T>C	c.(421-423)atT>atC	p.I141I		NM_014740.3	NP_055555.1	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A3	141	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TGGTGCCTCCAATGCAGGCAT	0.542000													35	58					0	0	0.796494	0	0
PTGFRN	5738	broad.mit.edu	37	1	117491858	117491858	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:117491858A>G	ENST00000393203.2	+	4	1024	c.877A>G	c.(877-879)Aag>Gag	p.K293E		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	293	Ig-like C2-type 3.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GGCTGAAGGAAAGGAACTGGA	0.498000													55	41					0	0	0.870114	0	0
SLC3A2	6520	broad.mit.edu	37	11	62623778	62623778	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:62623778G>A	ENST00000377892.1	+	1	261	c.37G>A	c.(37-39)Gtg>Atg	p.V13M	SLC3A2_ENST00000535296.1_Missense_Mutation_p.V13M|SLC3A2_ENST00000377889.2_Missense_Mutation_p.V13M|SLC3A2_ENST00000377890.2_Missense_Mutation_p.V13M|SLC3A2_ENST00000377891.2_Missense_Mutation_p.V13M			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	13					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						GATCGCCGTCGTGTCGATTCC	0.632000													31	83					0	0	0.834066	0	0
OR10G7	390265	broad.mit.edu	37	11	123909233	123909233	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:123909233G>A	ENST00000330487.5	-	1	484	c.476C>T	c.(475-477)aCc>aTc	p.T159I		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGTCAATATGGTCTGGACAGC	0.572000													9	317					0	0	0.500413	0	0
CXXC1	30827	broad.mit.edu	37	18	47812979	47812979	+	Silent	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:47812979A>G	ENST00000285106.6	-	3	867	c.153T>C	c.(151-153)caT>caC	p.H51H	CXXC1_ENST00000412036.2_Silent_p.H51H|CXXC1_ENST00000589940.1_Silent_p.H51H|CXXC1_ENST00000587396.1_5'UTR	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	51					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TGCAGTCCCCATGGAACCACT	0.632000													46	136					0	0	0.870114	0	0
KIAA0319	9856	broad.mit.edu	37	6	24559327	24559327	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:24559327G>A	ENST00000535378.1	-	18	3263	c.2621C>T	c.(2620-2622)gCt>gTt	p.A874V	KIAA0319_ENST00000543707.1_Missense_Mutation_p.A883V|KIAA0319_ENST00000378214.3_Missense_Mutation_p.A883V|KIAA0319_ENST00000537886.1_Missense_Mutation_p.A883V|KIAA0319_ENST00000430948.2_Missense_Mutation_p.A838V	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	883					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GGCCACTTCAGCAGCTTTGAG	0.507000													5	31					0	0	0.184627	0	0
LRP2	4036	broad.mit.edu	37	2	170030631	170030631	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:170030631T>C	ENST00000263816.3	-	56	11097	c.10812A>G	c.(10810-10812)aaA>aaG	p.K3604K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3604	LDL-receptor class A 28.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGATGCAACGTTTGTTGGCGC	0.507000													38	57					0	0	0.812448	0	0
RNF14	9604	broad.mit.edu	37	5	141357883	141357883	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:141357883A>G	ENST00000394520.2	+	5	631	c.322A>G	c.(322-324)Aag>Gag	p.K108E	RNF14_ENST00000394514.2_5'UTR|RNF14_ENST00000394519.1_Missense_Mutation_p.K108E|RNF14_ENST00000347642.3_Missense_Mutation_p.K108E|RNF14_ENST00000394515.3_Intron|RNF14_ENST00000502341.1_3'UTR|RNF14_ENST00000356143.1_Missense_Mutation_p.K108E|RNF14_ENST00000540015.1_Intron|AC005740.5_ENST00000520882.1_RNA	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	108	RWD.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		TGCTCTATGCAAGCACTTAGA	0.448000													44	93					0	0	0.864702	0	0
TSHR	7253	broad.mit.edu	37	14	81609994	81609994	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:81609994G>A	ENST00000541158.2	+	11	1914	c.1592G>A	c.(1591-1593)cGg>cAg	p.R531Q	TSHR_ENST00000298171.2_Missense_Mutation_p.R531Q|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	531					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CGCCTGGACCGGAAGATCCGC	0.567000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						84	22					0	0	0.870114	0	0
HOXC11	3227	broad.mit.edu	37	12	54367383	54367383	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:54367383T>A	ENST00000546378.1	+	1	474	c.358T>A	c.(358-360)Tcc>Acc	p.S120T	HOTAIR_ENST00000455246.1_RNA|HOXC11_ENST00000243082.4_Missense_Mutation_p.S120T|HOTAIR_ENST00000424518.1_RNA			O43248	HXC11_HUMAN	homeobox C11	120					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						AAACGAAGGCTCCTACGGCGG	0.637000			T	NUP98	AML								81	116					0	0	0.870114	0	0
MCOLN1	57192	broad.mit.edu	37	19	7595355	7595355	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:7595355G>A	ENST00000264079.6	+	12	1668	c.1543G>A	c.(1543-1545)Gcg>Acg	p.A515T		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	515					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCTCTTCATCGCGCTCATCAC	0.622000													122	84					0	0	0.870114	0	0
ZNF12	7559	broad.mit.edu	37	7	6731351	6731351	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:6731351G>C	ENST00000405858.1	-	5	1763	c.1222C>G	c.(1222-1224)Ctc>Gtc	p.L408V	ZNF12_ENST00000404360.1_Missense_Mutation_p.L334V|ZNF12_ENST00000342651.5_Missense_Mutation_p.L370V|AC073343.13_ENST00000366167.2_RNA	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	408					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CACTTGTAGAGTTTCACACCT	0.453000													19	60					0	0	0.539581	0	0
ASB13	79754	broad.mit.edu	37	10	5690974	5690974	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:5690974G>A	ENST00000357700.6	-	4	502	c.476C>T	c.(475-477)gCc>gTc	p.A159V	ASB13_ENST00000479033.1_5'UTR	NM_024701.3	NP_078977.2	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box containing 13	159					intracellular signal transduction		protein binding			NS(1)|endometrium(3)|lung(3)|ovary(1)	8				GBM - Glioblastoma multiforme(2;9.59e-09)		ATGCTCCCGGGCACAGGCAAC	0.572000													21	60					0	0	0.654019	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126283516	126283516	+	Silent	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:126283516T>C	ENST00000526727.1	+	9	1262	c.888T>C	c.(886-888)taT>taC	p.Y296Y	ST3GAL4_ENST00000356132.4_Silent_p.Y302Y|ST3GAL4_ENST00000530591.1_Silent_p.Y292Y|ST3GAL4_ENST00000534457.1_Silent_p.Y291Y|ST3GAL4_ENST00000532243.1_Silent_p.Y295Y|ST3GAL4_ENST00000444328.2_Silent_p.Y296Y|ST3GAL4_ENST00000534083.1_Silent_p.Y296Y|ST3GAL4_ENST00000392669.2_Silent_p.Y296Y|ST3GAL4_ENST00000449406.2_Silent_p.Y285Y|ST3GAL4_ENST00000227495.6_Silent_p.Y292Y			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	296					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		TTCACTACTATGAGCAGATCA	0.587000													5	85					0	0	0.217242	0	0
FREM2	341640	broad.mit.edu	37	13	39262566	39262566	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:39262566C>A	ENST00000280481.7	+	1	1301	c.1085C>A	c.(1084-1086)cCa>cAa	p.P362Q		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	362					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTTACTTCTCCATTCCAGCCT	0.577000													29	81					9.04072e-19	9.82432e-19	0.779181	1	0
USP13	8975	broad.mit.edu	37	3	179478997	179478997	+	Silent	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:179478997C>T	ENST00000263966.3	+	17	2517	c.2046C>T	c.(2044-2046)ggC>ggT	p.G682G	USP13_ENST00000496897.1_Silent_p.G617G	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	682	UBA 1.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GAAATATGGGCGCCGAGGTGG	0.522000													8	200					0	0	0.307466	0	0
KPNA1	3836	broad.mit.edu	37	3	122170886	122170886	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:122170886G>A	ENST00000344337.6	-	7	766	c.590C>T	c.(589-591)gCt>gTt	p.A197V	KPNA1_ENST00000466923.1_5'UTR	NM_002264.3	NP_002255.3	P52294	IMA1_HUMAN	karyopherin alpha 1 (importin alpha 5)	197	NLS binding site (major) (By similarity).				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity			NS(1)|breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	21				GBM - Glioblastoma multiforme(114;0.0898)		ACTATCTCCAGCAATGTTGCC	0.378000													60	334					0	0	0.870114	0	0
ZNF236	7776	broad.mit.edu	37	18	74587548	74587548	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:74587548C>A	ENST00000253159.8	+	6	960	c.762C>A	c.(760-762)gcC>gcA	p.A254A	ZNF236_ENST00000320610.9_Silent_p.A256A	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	254					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AACCCCATGCCTGTGCCTTCT	0.532000											OREG0025069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	76	108					6.43283e-47	7.21438e-47	0.870114	1	0
LRPPRC	10128	broad.mit.edu	37	2	44175571	44175571	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:44175571A>G	ENST00000260665.7	-	17	1879	c.1822T>C	c.(1822-1824)Ttc>Ctc	p.F608L		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	608					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCTGATGGAAGTATTGTCTC	0.388000													63	120					0	0	0.870114	0	0
DSP	1832	broad.mit.edu	37	6	7583192	7583192	+	Silent	SNP	C	C	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:7583192C>A	ENST00000379802.3	+	24	6038	c.5697C>A	c.(5695-5697)atC>atA	p.I1899I	DSP_ENST00000418664.2_Silent_p.I1300I	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1899	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGAGTGAGATCGAAAGACTCC	0.458000													33	75					1.80694e-10	1.90682e-10	0.740014	1	0
SLITRK6	84189	broad.mit.edu	37	13	86368261	86368261	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:86368261C>T	ENST00000400286.2	-	2	2981	c.2383G>A	c.(2383-2385)Gaa>Aaa	p.E795K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	795						integral to membrane		p.E795K(1)		breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTCAGCTCTTCGTGGGCTCCA	0.393000													108	181					0	0	0.870114	0	0
CAMKK1	84254	broad.mit.edu	37	17	3775908	3775908	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:3775908T>C	ENST00000381771.2	-	13	1325	c.1178A>G	c.(1177-1179)gAc>gGc	p.D393G	CAMKK1_ENST00000348335.2_Missense_Mutation_p.D355G|CAMKK1_ENST00000381769.2_Missense_Mutation_p.D382G|CAMKK1_ENST00000158166.5_Missense_Mutation_p.D393G			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	355	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		GATGAAATCGTCGATGAATGG	0.612000													10	39					0	0	0.411799	0	0
THADA	63892	broad.mit.edu	37	2	43801837	43801837	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:43801837G>A	ENST00000403856.1	-	12	1514	c.1367C>T	c.(1366-1368)aCg>aTg	p.T456M	THADA_ENST00000415080.2_Missense_Mutation_p.T166M|THADA_ENST00000405975.2_Missense_Mutation_p.T456M|THADA_ENST00000405006.4_Missense_Mutation_p.T456M|THADA_ENST00000330266.7_Missense_Mutation_p.T166M|THADA_ENST00000402360.2_Missense_Mutation_p.T456M|THADA_ENST00000404790.1_Missense_Mutation_p.T456M			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	456							binding	p.T456M(1)		breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACCAAGGCACGTGTACTTTCC	0.418000													9	213					0	0	0.335167	0	0
PAQR7	164091	broad.mit.edu	37	1	26189565	26189567	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:26189565_26189567delAGA	ENST00000374296.3	-	2	1430_1432	c.764_766delTCT	c.(763-768)tct>t	p.FS255del	RP1-125I3.2_ENST00000455431.1_RNA	NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	255					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		ATGAAGGTAGAGAAGAAGGCAGC	0.576													18	19	---	---	---	---					
EPB41	2035	broad.mit.edu	37	1	29314068	29314068	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:29314068delA	ENST00000343067.4	+	2	246	c.119delA	c.(118-120)cafs	p.Q40fs	EPB41_ENST00000398863.2_Frame_Shift_Del_p.Q40fs|EPB41_ENST00000373797.1_Frame_Shift_Del_p.Q40fs|EPB41_ENST00000373798.1_Frame_Shift_Del_p.Q40fs|EPB41_ENST00000356093.2_Frame_Shift_Del_p.Q40fs|EPB41_ENST00000349460.4_5'UTR|EPB41_ENST00000347529.3_Frame_Shift_Del_p.Q40fs|EPB41_ENST00000373800.3_5'UTR	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	40					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GAATCTTGTCAAACAGCAGCT	0.468													106	82	---	---	---	---					
TINAGL1	64129	broad.mit.edu	37	1	32050813	32050813	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:32050813delC	ENST00000271064.7	+	8	995	c.919delC	c.(919-921)ccfs	p.P308fs	TINAGL1_ENST00000457433.2_Frame_Shift_Del_p.P277fs|TINAGL1_ENST00000481165.1_3'UTR	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	308					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		TGGCCCTGCGCCCCCCTGTAT	0.602													11	116	---	---	---	---					
FAAH	2166	broad.mit.edu	37	1	46871324	46871324	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:46871324delG	ENST00000243167.8	+	5	727	c.643delG	c.(643-645)ggfs	p.G216fs	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	216					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	CAAAAGCCCAGGGGGCTCCTC	0.627													70	111	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115527421	115527421	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:115527421delA	ENST00000369522.3	+	30	2875	c.2635delA	c.(2635-2637)aafs	p.K881fs	SYCP1_ENST00000369518.1_Frame_Shift_Del_p.K881fs|SYCP1_ENST00000477590.1_Intron	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	881					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding	p.K881fs*21(1)	RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGAAGAAAGTAAAAAAAAGAG	0.264													8	156	---	---	---	---					
PI4KB	5298	broad.mit.edu	37	1	151288484	151288484	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:151288484delG	ENST00000368875.2	-	3	1090	c.510delC	c.(508-510)gcfs	p.A170fs	PI4KB_ENST00000368874.4_Frame_Shift_Del_p.A158fs|PI4KB_ENST00000368872.1_Frame_Shift_Del_p.A158fs|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000271657.5_Frame_Shift_Del_p.A170fs|PI4KB_ENST00000368873.1_Frame_Shift_Del_p.A158fs	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	158					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCCAATGTAGGCTTGTACTC	0.488													65	110	---	---	---	---					
UBQLN4	56893	broad.mit.edu	37	1	156011344	156011344	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:156011344delC	ENST00000368309.3	-	10	1677	c.1585delG	c.(1585-1587)ctfs	p.A529fs	UBQLN4_ENST00000368307.1_Frame_Shift_Del_p.G181fs	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	529						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GCGCTGGAAGCCCCTGTTGGA	0.627													19	59	---	---	---	---					
COPA	1314	broad.mit.edu	37	1	160295426	160295427	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:160295426_160295427insT	ENST00000241704.7	-	7	741_742	c.512_513insA	c.(511-513)actfs	p.T171fs	COPA_ENST00000368069.3_Frame_Shift_Ins_p.T171fs	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	171					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAGGGGACAGGTTTTTTTTCCT	0.406													61	223	---	---	---	---					
ARHGAP30	257106	broad.mit.edu	37	1	161026313	161026313	+	Frame_Shift_Del	DEL	A	A	-	rs17854839		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:161026313delA	ENST00000368013.3	-	3	530	c.210delT	c.(208-210)ttfs	p.F70fs	ARHGAP30_ENST00000368015.1_Intron|ARHGAP30_ENST00000368016.3_Frame_Shift_Del_p.F70fs	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	70	Rho-GAP.		F -> L (in dbSNP:rs17854839).		regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCTCTGACTCAAATTCCTGCC	0.592													17	29	---	---	---	---					
LOC400800	400800	broad.mit.edu	37	1	199130171	199130172	+	RNA	INS	-	-	G	rs145131094	by1000genomes	TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:199130171_199130172insG	ENST00000452199.1	+	0	140																											gaaggaaggaagaaggaaggaa	0.470													3	4	---	---	---	---					
PLEKHA6	22874	broad.mit.edu	37	1	204228411	204228411	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:204228411delC	ENST00000272203.3	-	8	1298	c.982delG	c.(982-984)tafs	p.V328fs	PLEKHA6_ENST00000414478.1_Frame_Shift_Del_p.V348fs	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	328	Pro-rich.							p.V328fs*172(2)		breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGCGGGGGTACCCCCCGGCGC	0.622													24	56	---	---	---	---					
TMCC2	9911	broad.mit.edu	37	1	205238671	205238671	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:205238671delC	ENST00000358024.3	+	3	1730	c.1341delC	c.(1339-1341)gafs	p.D447fs	TMCC2_ENST00000329800.7_Frame_Shift_Del_p.D207fs|TMCC2_ENST00000330675.7_Frame_Shift_Del_p.D222fs|TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000545499.1_Frame_Shift_Del_p.D369fs	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	447						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACCTGAAGGACCCCCTGGAAG	0.642													39	96	---	---	---	---					
CR2	1380	broad.mit.edu	37	1	207643042	207643043	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:207643042_207643043insT	ENST00000367057.3	+	6	1009_1010	c.820_821insT	c.(820-822)tttfs	p.F274fs	CR2_ENST00000367058.3_Frame_Shift_Ins_p.F274fs|CR2_ENST00000367059.3_Frame_Shift_Ins_p.F274fs|CR2_ENST00000458541.2_Frame_Shift_Ins_p.F274fs|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	274	Sushi 5.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCCCCTAGAAATTTTTTGCCCA	0.416													69	136	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222435119	222435119	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:222435119delT	ENST00000416510.1	-	0	167																											CAATAATTTCTTTTTTTTTTA	0.299													4	5	---	---	---	---					
AHCTF1	25909	broad.mit.edu	37	1	247007131	247007131	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:247007131delT	ENST00000366508.1	-	34	6732	c.6596delA	c.(6595-6597)acfs	p.N2199fs	AHCTF1_ENST00000391829.2_Frame_Shift_Del_p.N2164fs|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000326225.3_Frame_Shift_Del_p.N2173fs			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	2164	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ATTGGATGTGTTTTTTTGTCT	0.313													19	61	---	---	---	---					
OR2L5	81466	broad.mit.edu	37	1	248185773	248185774	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:248185773_248185774insT	ENST00000355281.1	+	1	524_525	c.524_525insT	c.(523-525)cttfs	p.L175fs	OR2L13_ENST00000366478.2_Intron	NM_001258284.1	NP_001245213.1			olfactory receptor, family 2, subfamily L, member 5																		GCCATCAATCATTTTTTCTGTG	0.426													66	209	---	---	---	---					
OR2T34	127068	broad.mit.edu	37	1	248738032	248738034	+	In_Frame_Del	DEL	CTG	CTG	-	rs147194614		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr1:248738032_248738034delCTG	ENST00000328782.2	-	1	46_48	c.25_27delCAG	c.(25-27)del	p.Q9del		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGTTTGATTCTGAGAAGTCTGA	0.448													39	95	---	---	---	---					
NOL10	79954	broad.mit.edu	37	2	10729704	10729704	+	Splice_Site	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:10729704delT	ENST00000345985.3	-	17	1556	c.1446_splice	c.e17+1	p.K482_splice	NOL10_ENST00000542668.1_Splice_Site_p.K482_splice|NOL10_ENST00000381685.5_Splice_Site_p.K532_splice|NOL10_ENST00000538384.1_Splice_Site_p.K506_splice|AC092687.5_ENST00000414538.1_RNA	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	532						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		AGTACATTACTTTTTCACGAA	0.299													17	49	---	---	---	---					
ATAD2B	54454	broad.mit.edu	37	2	24042679	24042682	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:24042679_24042682delTGAG	ENST00000238789.5	-	17	2545_2548	c.2202_2205delCTCA	c.(2200-2205)cafs	p.HS734fs	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	734							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGGTGATCCTGAGTGACAATTGG	0.314													21	65	---	---	---	---					
FBXO11	80204	broad.mit.edu	37	2	48050443	48050443	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:48050443delT	ENST00000403359.3	-	12	1527	c.1455delA	c.(1453-1455)aafs	p.K485fs	FBXO11_ENST00000316377.4_Frame_Shift_Del_p.K401fs|FBXO11_ENST00000402508.1_Frame_Shift_Del_p.K401fs|FBXO11_ENST00000434523.2_5'UTR	NM_001190274.1	NP_001177203.1	Q86XK2	FBX11_HUMAN	F-box protein 11	485					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.0?(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TAGCATAGGCTTTTACTTCAA	0.368			"""Mis, F, D"""		DLBCL								30	71	---	---	---	---					
EXOC6B	23233	broad.mit.edu	37	2	72725651	72725651	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:72725651delA	ENST00000272427.6	-	13	1399	c.1269delT	c.(1267-1269)ttfs	p.F423fs	EXOC6B_ENST00000410104.1_Frame_Shift_Del_p.F423fs	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	423					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						ACAGCATGTCAAAAAGCTGAT	0.338													24	45	---	---	---	---					
IKZF2	22807	broad.mit.edu	37	2	214012391	214012392	+	Frame_Shift_Ins	INS	-	-	AC			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:214012391_214012392insAC	ENST00000442445.1	-	3	254_255	c.197_198insGT	c.(196-198)gtcfs	p.V66fs	IKZF2_ENST00000413091.3_Intron|IKZF2_ENST00000451136.2_Intron|IKZF2_ENST00000421754.2_Intron|IKZF2_ENST00000457361.1_Intron|IKZF2_ENST00000374319.4_Intron|IKZF2_ENST00000434687.1_Intron|IKZF2_ENST00000374327.4_Intron|IKZF2_ENST00000342002.2_Intron			Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TTGCTGGAGAGACACACACACA	0.401													43	213	---	---	---	---					
SLC11A1	6556	broad.mit.edu	37	2	219252307	219252307	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:219252307delT	ENST00000233202.6	+	7	931	c.591delT	c.(589-591)gcfs	p.A197fs	SLC11A1_ENST00000539932.1_Frame_Shift_Del_p.A79fs	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	197					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCTGGAAGCTTTTTTTGGAC	0.448													287	607	---	---	---	---					
CCDC108	255101	broad.mit.edu	37	2	219900111	219900111	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:219900111delT	ENST00000295729.2	-	4	561	c.438delA	c.(436-438)aafs	p.K146fs	CCDC108_ENST00000410037.1_Intron|CCDC108_ENST00000453220.1_Intron|CCDC108_ENST00000441968.1_Intron|CCDC108_ENST00000324264.6_Frame_Shift_Del_p.K146fs|CCDC108_ENST00000341552.5_Intron|CCDC108_ENST00000409865.3_Intron	NM_152389.2	NP_689602.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	0						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGTTAAAGgttttttttgtt	0.378													17	26	---	---	---	---					
CXXC11	285093	broad.mit.edu	37	2	242814374	242814375	+	Frame_Shift_Ins	INS	-	-	C	rs35989328		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr2:242814374_242814375insC	ENST00000343216.3	+	2	695_696	c.667_668insC	c.(667-669)cccfs	p.P223fs		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	223						integral to membrane											TGAGGGCCCTGCCCCCCCTGCG	0.658													14	58	---	---	---	---					
MLH1	4292	broad.mit.edu	37	3	37070364	37070365	+	Frame_Shift_Ins	INS	-	-	CATTAACCTCA	rs63751146		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:37070364_37070365insCATTAACCTCA	ENST00000231790.2	+	13	1715_1716	c.1499_1500insCATTAACCTCA	c.(1498-1500)aatfs	p.N500fs	MLH1_ENST00000536378.1_Frame_Shift_Ins_p.N259fs|MLH1_ENST00000455445.2_Frame_Shift_Ins_p.N259fs|MLH1_ENST00000435176.1_Frame_Shift_Ins_p.N402fs|MLH1_ENST00000458205.2_Frame_Shift_Ins_p.N259fs|MLH1_ENST00000539477.1_Frame_Shift_Ins_p.N259fs	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	500	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						CGGAGAAGGATCATTAACCTCA	0.485		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				33	246	---	---	---	---					
LRRFIP2	9209	broad.mit.edu	37	3	37125271	37125271	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:37125271delT	ENST00000421307.1	-	20	1556	c.1134delA	c.(1132-1134)aafs	p.K378fs	LRRFIP2_ENST00000336686.4_Frame_Shift_Del_p.K378fs|LRRFIP2_ENST00000440230.1_Frame_Shift_Del_p.K146fs|LRRFIP2_ENST00000396428.2_Frame_Shift_Del_p.K194fs|LRRFIP2_ENST00000421276.2_Frame_Shift_Del_p.K146fs|LRRFIP2_ENST00000354379.4_Frame_Shift_Del_p.K122fs	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	378					Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CTTTCTTGTATTTTTCTTCCA	0.338													69	71	---	---	---	---					
SCN11A	11280	broad.mit.edu	37	3	38949441	38949441	+	Splice_Site	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:38949441delT	ENST00000450244.1	-	10	1670	c.1473_splice	c.e10+1	p.K491_splice	SCN11A_ENST00000456224.3_Splice_Site_p.K491_splice|SCN11A_ENST00000444237.2_Splice_Site_p.K491_splice|SCN11A_ENST00000302328.3_Splice_Site_p.K491_splice			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	491					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGACTTACCTTTTTTTGGCA	0.388													75	73	---	---	---	---					
ZNF619	285267	broad.mit.edu	37	3	40524165	40524165	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:40524165delG	ENST00000447116.2	+	5	692	c.385delG	c.(385-387)ggfs	p.G130fs	ZNF619_ENST00000456778.1_Frame_Shift_Del_p.G46fs|ZNF619_ENST00000432264.2_Frame_Shift_Del_p.G90fs|ZNF619_ENST00000522736.1_Frame_Shift_Del_p.W56fs|ZNF619_ENST00000521353.1_Frame_Shift_Del_p.G130fs|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000429348.2_Frame_Shift_Del_p.G90fs|ZNF619_ENST00000314686.5_Frame_Shift_Del_p.W56fs	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	130					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GACACTTGCTGGGGGAGAGGC	0.522													60	64	---	---	---	---					
TMF1	7110	broad.mit.edu	37	3	69088741	69088741	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:69088741delT	ENST00000543976.1	-	6	2043	c.1797delA	c.(1795-1797)aafs	p.K599fs	CTD-2013N24.2_ENST00000596274.1_RNA|TMF1_ENST00000398559.2_Frame_Shift_Del_p.K596fs|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000596523.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	596					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GCTCTTTAACTTTTTTGTTCA	0.328													64	97	---	---	---	---					
AMOTL2	51421	broad.mit.edu	37	3	134086562	134086562	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:134086562delG	ENST00000514516.1	-	3	1170	c.992delC	c.(991-993)ctfs	p.P333fs	AMOTL2_ENST00000513145.1_Frame_Shift_Del_p.P275fs|AMOTL2_ENST00000249883.5_Frame_Shift_Del_p.P275fs|AMOTL2_ENST00000422605.2_Frame_Shift_Del_p.P275fs	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	275										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						ATGTGGGGGAGGGGGGTGCTC	0.647													7	40	---	---	---	---					
ESYT3	83850	broad.mit.edu	37	3	138187722	138187725	+	Splice_Site	DEL	GAGT	GAGT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:138187722_138187725delGAGT	ENST00000389567.4	+	14	1619_1620	c.1434_splice	c.e14+1	p.478_splice		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	478	C2 2.					integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						AGGTTTGCCAGAGTGAGTGAGTAT	0.495													100	324	---	---	---	---					
FETUB	26998	broad.mit.edu	37	3	186362544	186362544	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:186362544delA	ENST00000265029.3	+	4	530	c.429delA	c.(427-429)tcfs	p.S143fs	FETUB_ENST00000450521.1_Frame_Shift_Del_p.S143fs|FETUB_ENST00000382134.3_Frame_Shift_Del_p.S78fs|RP11-134F2.2_ENST00000455926.1_RNA|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000488561.1_3'UTR|FETUB_ENST00000382136.3_Frame_Shift_Del_p.S106fs|FETUB_ENST00000539949.1_5'UTR	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	143						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CAACAGTTTCAAAAAAAAAGA	0.418													11	231	---	---	---	---					
TNK2	10188	broad.mit.edu	37	3	195595228	195595229	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:195595228_195595229insG	ENST00000333602.6	-	12	2512_2513	c.1895_1896insC	c.(1894-1896)cccfs	p.P632fs	TNK2_ENST00000381916.2_Frame_Shift_Ins_p.P710fs|TNK2_ENST00000392400.1_Frame_Shift_Ins_p.P632fs|TNK2_ENST00000428187.1_Frame_Shift_Ins_p.P664fs	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	632	Pro-rich.|Required for interaction with NEDD4 (By similarity).|Required for interaction with SRC.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CATAGGCGGGCGGGGGGGGCAG	0.728													7	92	---	---	---	---					
PCYT1A	5130	broad.mit.edu	37	3	195969503	195969503	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr3:195969503delA	ENST00000292823.2	-	7	667	c.495delT	c.(493-495)ttfs	p.F165fs	PCYT1A_ENST00000419333.1_Frame_Shift_Del_p.F165fs|PCYT1A_ENST00000431016.1_Frame_Shift_Del_p.F165fs	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	165	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CATGGGCTACAAAATCAATCT	0.423													63	206	---	---	---	---					
IGFBP7	3490	broad.mit.edu	37	4	57898593	57898593	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:57898593delT	ENST00000537922.1	-	4	861	c.828delA	c.(826-828)aafs	p.K276fs	IGFBP7_ENST00000295666.4_Splice_Site_p.K276_splice|IGFBP7_ENST00000512512.1_5'UTR	NM_001253835.1	NP_001240764.1	Q16270	IBP7_HUMAN	insulin-like growth factor binding protein 7	276				PVKKGEGAEL -> ASEKR (in Ref. 1; AAA16187).	cell adhesion|negative regulation of cell proliferation|regulation of cell growth	extracellular space	insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|lung(3)	5	Glioma(25;0.08)|all_neural(26;0.181)				Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTGTGTACCTTTTTTCACTG	0.363													55	45	---	---	---	---					
ZFP42	132625	broad.mit.edu	37	4	188924487	188924487	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr4:188924487delC	ENST00000326866.4	+	4	934	c.526delC	c.(526-528)ccfs	p.P177fs	ZFP42_ENST00000509524.1_Frame_Shift_Del_p.P177fs	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	177					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TAGAAAGAAGCCCCCCATAAA	0.468													25	230	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24488218	24488219	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:24488218_24488219insT	ENST00000264463.4	-	12	2427_2428	c.1920_1921insA	c.(1918-1923)aaagccfs	p.A641fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	641					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATCAGAGGCTCTTTTTTTCGCT	0.406										HNSCC(23;0.051)			44	138	---	---	---	---					
AP3B1	8546	broad.mit.edu	37	5	77334907	77334907	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:77334907delT	ENST00000255194.6	-	23	2944	c.2769delA	c.(2767-2769)aafs	p.K923fs	AP3B1_ENST00000523204.1_5'UTR|AP3B1_ENST00000519295.1_Frame_Shift_Del_p.K874fs	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	923					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity	p.K923fs*4(1)		breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CTATAGGAAGTTTTTTTTCCC	0.289									Hermansky-Pudlak syndrome				52	106	---	---	---	---					
APC	324	broad.mit.edu	37	5	112176344	112176345	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:112176344_112176345insA	ENST00000457016.1	+	16	5433_5434	c.5053_5054insA	c.(5053-5055)aaafs	p.K1685fs	APC_ENST00000508376.2_Frame_Shift_Ins_p.K1685fs|APC_ENST00000257430.4_Frame_Shift_Ins_p.K1685fs|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1685	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGGTGAATTTGAAAAACGAGAT	0.436		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			27	60	---	---	---	---					
FTMT	94033	broad.mit.edu	37	5	121187789	121187789	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:121187789delC	ENST00000321339.1	+	1	140	c.131delC	c.(130-132)gcfs	p.A44fs		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	44					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		AGGCAGATCGCCCCCCGCCGC	0.776													5	6	---	---	---	---					
FNIP1	96459	broad.mit.edu	37	5	131066705	131066706	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:131066705_131066706delTT	ENST00000307968.7	-	3	244_245	c.245_246delAA	c.(244-246)afs	p.K82fs	FNIP1_ENST00000511848.1_Frame_Shift_Del_p.K82fs|FNIP1_ENST00000510461.1_Frame_Shift_Del_p.K82fs|FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000307954.8_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCCCAAAGACTTTAACTTGAGC	0.347													67	133	---	---	---	---					
SLC22A4	6583	broad.mit.edu	37	5	131663087	131663087	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:131663087delT	ENST00000200652.3	+	5	1116	c.942delT	c.(940-942)gafs	p.D314fs	AC034220.3_ENST00000417795.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	314					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGATATTTGATTCTGTGGAGG	0.378													39	109	---	---	---	---					
FSTL4	23105	broad.mit.edu	37	5	132534947	132534947	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:132534947delC	ENST00000265342.7	-	16	2618	c.2369delG	c.(2368-2370)gtfs	p.G790fs	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	790						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTGTGGGTACCCCCCCAGGG	0.597													11	43	---	---	---	---					
ANKHD1	54882	broad.mit.edu	37	5	139889312	139889312	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr5:139889312delC	ENST00000297183.6	+	21	3980	c.3856delC	c.(3856-3858)ccfs	p.P1287fs	ANKHD1_ENST00000360839.2_Frame_Shift_Del_p.P1287fs|ANKHD1-EIF4EBP3_ENST00000532219.1_Frame_Shift_Del_p.P1287fs	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTAATGCTCCCCCTGTGCC	0.438													17	120	---	---	---	---					
MBOAT1	154141	broad.mit.edu	37	6	20151474	20151475	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:20151474_20151475insA	ENST00000324607.7	-	3	428_429	c.264_265insT	c.(262-267)tttgctfs	p.A89fs	MBOAT1_ENST00000536798.1_Frame_Shift_Ins_p.A89fs|MBOAT1_ENST00000541730.1_5'UTR	NM_001080480.1	NP_001073949.1	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	89					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			AACACCAGCACAAAAAGATGCA	0.371													67	195	---	---	---	---					
CDKAL1	54901	broad.mit.edu	37	6	21231246	21231246	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:21231246delT	ENST00000274695.4	+	16	1883	c.1716delT	c.(1714-1716)gcfs	p.A572fs	CDKAL1_ENST00000378610.1_Frame_Shift_Del_p.A572fs|CDKAL1_ENST00000476517.1_3'UTR|CDKAL1_ENST00000378624.4_Frame_Shift_Del_p.A481fs	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	572					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			TTCTTTTTGCTTTTTTTGTCA	0.413													25	180	---	---	---	---					
PPP1R10	5514	broad.mit.edu	37	6	30570264	30570266	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:30570264_30570266delGGA	ENST00000376511.2	-	19	2712_2714	c.2160_2162delTCC	c.(2158-2163)cca>cc	p.PP720del		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	720	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						GCCTCGGAATggaggaggaggag	0.670													9	55	---	---	---	---					
KLHL31	401265	broad.mit.edu	37	6	53519514	53519514	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:53519514delT	ENST00000370905.3	-	2	697	c.557delA	c.(556-558)atfs	p.N186fs	KLHL31_ENST00000407079.1_Frame_Shift_Del_p.N186fs	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	186	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					TGCTTTTGCATTTTTTAGGGA	0.343													69	123	---	---	---	---					
PHF3	23469	broad.mit.edu	37	6	64395266	64395267	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:64395266_64395267insA	ENST00000262043.3	+	4	1983_1984	c.1643_1644insA	c.(1642-1644)aaafs	p.K548fs	PHF3_ENST00000509330.1_Frame_Shift_Ins_p.K548fs|PHF3_ENST00000393387.1_Frame_Shift_Ins_p.K548fs			Q92576	PHF3_HUMAN	PHD finger protein 3	548					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GTCAAAGTCAGAAAAAAACAAA	0.337													32	76	---	---	---	---					
MCHR2	84539	broad.mit.edu	37	6	100382358	100382358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:100382358delA	ENST00000281806.2	-	5	937	c.623delT	c.(622-624)tcfs	p.F208fs	MCHR2_ENST00000369212.1_Frame_Shift_Del_p.F208fs|MCHR2_ENST00000445970.1_Frame_Shift_Del_p.F208fs	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	208						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.F208fs*5(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GGGTAGAGGGAAAAAAAAAGT	0.343													68	152	---	---	---	---					
ARHGAP18	93663	broad.mit.edu	37	6	129937433	129937434	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:129937433_129937434insA	ENST00000368149.2	-	7	1055_1056	c.967_968insT	c.(967-969)cgtfs	p.R323fs		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	323					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CAATGGAACGCAAAAAAGACCA	0.337													18	78	---	---	---	---					
SERAC1	84947	broad.mit.edu	37	6	158532468	158532468	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:158532468delT	ENST00000367104.3	-	17	2026	c.1895delA	c.(1894-1896)agfs	p.K632fs	SERAC1_ENST00000367102.2_3'UTR	NM_032861.3	NP_116250.3	Q96JX3	SRAC1_HUMAN	serine active site containing 1	632					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AAAAGCATCCTTTTTCTTTGG	0.338													45	81	---	---	---	---					
TULP4	56995	broad.mit.edu	37	6	158923024	158923024	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr6:158923024delC	ENST00000367097.3	+	13	3686	c.2329delC	c.(2329-2331)ccfs	p.P779fs	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	779					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GTCCCTGCCTCCCCCGCCGCA	0.632													21	147	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11676288	11676291	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:11676288_11676291delTCTT	ENST00000423059.3	-	2	739_742	c.488_491delAAGA	c.(487-492)acfs	p.KD165fs	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	165						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AATGTCTTTGTCTTTCTGGATGCA	0.490										HNSCC(18;0.044)			31	77	---	---	---	---					
CCT6P1	643253	broad.mit.edu	37	7	65222951	65222951	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:65222951delT	ENST00000442266.1	+	0	561																											TTTCTGTAACTTTTTTTTTTT	0.323													17	18	---	---	---	---					
GS1-124K5.2	0	broad.mit.edu	37	7	65888988	65888988	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:65888988delT	ENST00000442578.1	-	0	826																											tttttttttcttttttttttt	0.488													4	3	---	---	---	---					
GTF2IRD1P1	729156	broad.mit.edu	37	7	66304731	66304731	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:66304731delT	ENST00000457166.1	-	0	189					NR_003934.1																						TTTCTTTCCCttttttttttt	0.512													4	2	---	---	---	---					
CLDN4	1364	broad.mit.edu	37	7	73246063	73246063	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:73246063delG	ENST00000435050.1	+	2	3212	c.532delG	c.(532-534)ggfs	p.G179fs	CLDN4_ENST00000431918.1_Frame_Shift_Del_p.G179fs|CLDN4_ENST00000340958.2_Frame_Shift_Del_p.G179fs			O14493	CLD4_HUMAN	claudin 4	179					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				GCTCCTTGGCGGGGGGCTGCT	0.642													17	62	---	---	---	---					
AC006988.1	0	broad.mit.edu	37	7	88269891	88269892	+	RNA	DEL	TT	TT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:88269891_88269892delTT	ENST00000390184.1	+	0	57_58																											GAAGGAGCACTTTTTTTTTTTT	0.317													3	4	---	---	---	---					
AZGP1P1	646282	broad.mit.edu	37	7	99581178	99581179	+	RNA	INS	-	-	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:99581178_99581179insC	ENST00000425474.1	+	0	499_500					NR_036679.1																						TCCGCATCCCACCCCCCCCACA	0.579													2	4	---	---	---	---					
CNPY4	245812	broad.mit.edu	37	7	99717401	99717402	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:99717401_99717402insT	ENST00000262932.3	+	1	166_167	c.34_35insT	c.(34-36)tttfs	p.F12fs	RP11-506M12.1_ENST00000494221.1_RNA|TAF6_ENST00000437822.2_5'UTR	NM_152755.1	NP_689968.1	Q8N129	CNPY4_HUMAN	canopy FGF signaling regulator 4	12						extracellular region				breast(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTGCTTTTCCTTTTTTTGGCC	0.525													25	84	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100482088	100482090	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:100482088_100482090delAAG	ENST00000388793.4	+	7	1077_1079	c.857_859delAAG	c.(856-861)aaa>a	p.KE286del	SRRT_ENST00000457580.2_In_Frame_Del_p.KE286del|SRRT_ENST00000432932.1_In_Frame_Del_p.KE286del|SRRT_ENST00000347433.4_In_Frame_Del_p.KE286del	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	286	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCCAGCAAGAAAGAAGAAGGACG	0.596													15	26	---	---	---	---					
OR2A7	401427	broad.mit.edu	37	7	143956190	143956190	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr7:143956190delA	ENST00000493325.1	-	1	625	c.532delT	c.(532-534)gtfs	p.C178fs	RP4-798C17.6_ENST00000476560.1_RNA|RP4-798C17.6_ENST00000478806.1_RNA|RP4-798C17.6_ENST00000487102.1_RNA|RP4-798C17.6_ENST00000461843.1_RNA|RP4-798C17.6_ENST00000463561.1_RNA|ARHGEF35_ENST00000543357.1_Intron|RP4-545C24.1_ENST00000460955.1_RNA|RP4-798C17.6_ENST00000489488.1_RNA	NM_001005328.1	NP_001005328.1	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A, member 7	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					AAGATTTCACAAAAAAAGTGA	0.458													7	50	---	---	---	---					
LONRF1	91694	broad.mit.edu	37	8	12592895	12592900	+	In_Frame_Del	DEL	GGCTCA	GGCTCA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:12592895_12592900delGGCTCA	ENST00000398246.3	-	7	1530_1535	c.1461_1466delTGAGCC	c.(1459-1467)tta>tt	p.FEP487del	LONRF1_ENST00000533751.1_In_Frame_Del_p.FEP130del	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	487					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		GGTTGTTACTGGCTCAAAAAACAACC	0.359													13	19	---	---	---	---					
SLC7A13	157724	broad.mit.edu	37	8	87242135	87242135	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:87242135delA	ENST00000297524.3	-	1	475	c.372delT	c.(370-372)ttfs	p.F124fs	SLC7A13_ENST00000520624.1_Intron|SLC7A13_ENST00000419776.2_Frame_Shift_Del_p.F124fs	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	124						integral to membrane	amino acid transmembrane transporter activity	p.S126fs*20(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						AGCAGCTGGGAAAAAAAGGCT	0.488													7	101	---	---	---	---					
DCSTAMP	81501	broad.mit.edu	37	8	105367351	105367351	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:105367351delA	ENST00000297581.2	+	3	1325	c.1276delA	c.(1276-1278)aafs	p.K427fs	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Intron|DCSTAMP_ENST00000520080.1_3'UTR	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	427					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											AAAGCTGCTTAAAAAAAGATC	0.458													27	130	---	---	---	---					
EMC2	9694	broad.mit.edu	37	8	109482097	109482097	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:109482097delA	ENST00000220853.3	+	6	441	c.406delA	c.(406-408)aafs	p.K136fs	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		AGCCCAGGGGAAAAATGTGGA	0.388													9	86	---	---	---	---					
FER1L6-AS2	157376	broad.mit.edu	37	8	125164198	125164198	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:125164198delT	ENST00000520031.1	-	0	95					NR_103547.1																						CTTAAAGGGCTTTTTTGGCAC	0.547													9	15	---	---	---	---					
MROH1	727957	broad.mit.edu	37	8	145246743	145246745	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr8:145246743_145246745delCTT	ENST00000528919.1	+	8	961_963	c.840_842delCTT	c.(838-843)acc>ac	p.TF280del	MROH1_ENST00000398656.4_In_Frame_Del_p.TF280del|MROH1_ENST00000534366.1_In_Frame_Del_p.TF280del|MROH1_ENST00000423230.2_In_Frame_Del_p.TF280del|MROH1_ENST00000326134.5_In_Frame_Del_p.TF280del	NM_032450.2	NP_115826.2			maestro heat-like repeat family member 1																		ACGCAGAGACCTTCTACTTGTCC	0.621													19	42	---	---	---	---					
SPATA31D1	389763	broad.mit.edu	37	9	84606643	84606643	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:84606643delA	ENST00000344803.2	+	4	1305	c.1258delA	c.(1258-1260)aafs	p.K421fs		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GAGACAAGTCAAAAAAAGGGG	0.448													27	35	---	---	---	---					
NAA35	60560	broad.mit.edu	37	9	88631578	88631578	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:88631578delA	ENST00000361671.5	+	18	1826	c.1693delA	c.(1693-1695)aafs	p.K568fs		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	568					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						AAAAACAAAGAAAAAAAAGAA	0.378													26	40	---	---	---	---					
SPATA31C1	441452	broad.mit.edu	37	9	90534182	90534182	+	RNA	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:90534182delT	ENST00000602681.1	+	0	928																											TCATCTTGTCTCCCAGCGTCA	0.612													7	44	---	---	---	---					
FAM120A	23196	broad.mit.edu	37	9	96278286	96278286	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:96278286delG	ENST00000277165.6	+	7	1347	c.1153delG	c.(1153-1155)ggfs	p.G386fs	FAM120A_ENST00000333936.5_Frame_Shift_Del_p.G386fs|FAM120A_ENST00000375389.3_Frame_Shift_Del_p.G386fs|FAM120A_ENST00000340893.4_Frame_Shift_Del_p.G386fs	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	386	Interaction with YES1, SRC and FYN.					cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GCCCAGCCCAGGGGGCGCCCC	0.647													7	5	---	---	---	---					
PKN3	29941	broad.mit.edu	37	9	131482247	131482247	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:131482247delC	ENST00000291906.4	+	20	2720	c.2327delC	c.(2326-2328)gcfs	p.A776fs	PKN3_ENST00000485301.1_3'UTR	NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	776	Protein kinase.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AACATGGACGCCCCCTACCCC	0.627													22	92	---	---	---	---					
NOXA1	10811	broad.mit.edu	37	9	140327515	140327516	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr9:140327515_140327516delCT	ENST00000341349.2	+	9	1019_1020	c.839_840delCT	c.(838-840)cfs	p.P280fs	NOXA1_ENST00000392815.2_Frame_Shift_Del_p.P224fs	NM_001256067.1|NM_006647.1	NP_001242996.1|NP_006638.1	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	280			Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity			cervix(1)|large_intestine(2)|lung(2)|skin(3)|upper_aerodigestive_tract(1)	9	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		AAACAGGCTCCTCTCTCCCCAG	0.683													18	18	---	---	---	---					
FBXO18	84893	broad.mit.edu	37	10	5950982	5950982	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:5950982delA	ENST00000379999.5	+	5	1105	c.1001delA	c.(1000-1002)gafs	p.E334fs	FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000362091.4_Frame_Shift_Del_p.E283fs|FBXO18_ENST00000470089.1_3'UTR|FBXO18_ENST00000379994.1_Frame_Shift_Del_p.E20fs	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	283					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TGTGGCATAGAAAAGGAGTCA	0.468													8	221	---	---	---	---					
FRMD4A	55691	broad.mit.edu	37	10	13696451	13696452	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:13696451_13696452insG	ENST00000357447.2	-	23	3382_3383	c.3014_3015insC	c.(3013-3015)cagfs	p.Q1005fs	FRMD4A_ENST00000358621.4_Frame_Shift_Ins_p.Q990fs|FRMD4A_ENST00000378503.1_Frame_Shift_Ins_p.Q1005fs	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	1005	Ser-rich.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GGGGGCTGCTTGGGGGGGTGGC	0.535													18	147	---	---	---	---					
NRG3	10718	broad.mit.edu	37	10	83635237	83635238	+	Frame_Shift_Ins	INS	-	-	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:83635237_83635238insC	ENST00000404547.1	+	1	141_142	c.141_142insC	c.(139-144)gaccccfs	p.DP47fs	NRG3_ENST00000372141.2_Frame_Shift_Ins_p.DP47fs			P56975	NRG3_HUMAN	neuregulin 3	47					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GGGCGGCCGAGCCCCCCCGGGA	0.757													5	9	---	---	---	---					
HHEX	3087	broad.mit.edu	37	10	94454326	94454328	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:94454326_94454328delAAG	ENST00000282728.5	+	4	2413_2415	c.614_616delAAG	c.(613-618)aaa>a	p.KE205del	HHEX_ENST00000492654.2_In_Frame_Del_p.KE33del|HHEX_ENST00000472590.2_In_Frame_Del_p.KE33del	NM_002729.4	NP_002720.1	Q03014	HHEX_HUMAN	hematopoietically expressed homeobox	205					anterior/posterior pattern formation|B cell differentiation|cell cycle|DNA conformation change|negative regulation of angiogenesis|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of vascular endothelial growth factor receptor signaling pathway|poly(A)+ mRNA export from nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|Wnt receptor signaling pathway	cytoplasm|nucleus|protein-DNA complex	DNA bending activity|eukaryotic initiation factor 4E binding|protein homodimerization activity|repressing transcription factor binding|sequence-specific DNA binding|TBP-class protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(2)|lung(5)|ovary(1)	10						AGCAATAAAAAAGAAGAACTGGA	0.389													54	108	---	---	---	---					
DHX32	55760	broad.mit.edu	37	10	127548334	127548336	+	In_Frame_Del	DEL	ATA	ATA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr10:127548334_127548336delATA	ENST00000284690.3	-	3	1175_1177	c.685_687delTAT	c.(685-687)del	p.Y229del	DHX32_ENST00000284688.6_In_Frame_Del_p.Y229del	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	229	Helicase ATP-binding.					mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GCACGTTTCCATAATAAGAATTG	0.384													47	337	---	---	---	---					
KCNQ1	3784	broad.mit.edu	37	11	2609949	2609949	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:2609949delA	ENST00000155840.5	+	10	1366	c.1258delA	c.(1258-1260)aafs	p.K422fs	KCNQ1_ENST00000335475.5_Frame_Shift_Del_p.K295fs	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	422					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TTAGGTAAAGAAAAAAAAGTT	0.562													17	56	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6662142	6662142	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:6662142delG	ENST00000299441.3	-	2	1114	c.703delC	c.(703-705)ggfs	p.R236fs		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	236	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCCCTCCGGGGGGGTGAA	0.587													66	195	---	---	---	---					
AKIP1	56672	broad.mit.edu	37	11	8936454	8936454	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:8936454delT	ENST00000529876.1	+	2	565	c.304delT	c.(304-306)gcfs	p.C102fs	AKIP1_ENST00000299576.5_Frame_Shift_Del_p.C102fs|AKIP1_ENST00000534147.1_Frame_Shift_Del_p.C129fs|AKIP1_ENST00000396648.2_Frame_Shift_Del_p.C102fs|AKIP1_ENST00000309377.4_Frame_Shift_Del_p.C129fs|AKIP1_ENST00000525005.1_Frame_Shift_Del_p.C129fs|AKIP1_ENST00000534506.1_Frame_Shift_Del_p.C102fs|AKIP1_ENST00000309357.4_Frame_Shift_Del_p.C129fs			Q9NQ31	AKIP1_HUMAN	A kinase (PRKA) interacting protein 1	129						nucleus	protein binding			kidney(1)|large_intestine(2)|lung(2)	5						GCTGCACATGTGCTTGGACAT	0.468											OREG0020740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	81	---	---	---	---					
FBXO3	26273	broad.mit.edu	37	11	33792303	33792304	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:33792303_33792304insT	ENST00000530401.1	-	2	182_183	c.162_163insA	c.(160-165)aaactgfs	p.L55fs	FBXO3_ENST00000265651.3_Frame_Shift_Ins_p.L60fs|FBXO3_ENST00000448981.2_Frame_Shift_Ins_p.L60fs|FBXO3_ENST00000533103.1_5'UTR|FBXO3_ENST00000526785.1_5'UTR|FBXO3_ENST00000534136.1_Frame_Shift_Ins_p.L60fs			Q9UK99	FBX3_HUMAN	F-box protein 3	60	F-box.				proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		ATCAGCCAGTATTTTTTGCAAT	0.426													38	818	---	---	---	---					
LOC283194	283194	broad.mit.edu	37	11	58763346	58763347	+	RNA	DEL	GA	GA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:58763346_58763347delGA	ENST00000533954.1	-	0	507				RP11-142C4.6_ENST00000532098.1_RNA	NR_033853.1																						TCTGCCGCATGAGCATAAAATG	0.406													27	42	---	---	---	---					
FADS3	3995	broad.mit.edu	37	11	61644278	61644278	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:61644278delG	ENST00000540820.1	-	8	1115	c.1043delC	c.(1042-1044)cafs	p.P349fs	FADS3_ENST00000527697.1_Intron|FADS3_ENST00000525588.1_Intron|FADS3_ENST00000278829.2_Intron			Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	0					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						aagctcTGGTGGGGGGCTGCA	0.612													2	4	---	---	---	---					
HNRNPUL2	221092	broad.mit.edu	37	11	62484649	62484650	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:62484649_62484650delAA	ENST00000301785.5	-	11	1984_1985	c.1792_1793delTT	c.(1792-1794)gfs	p.L598fs	RP11-831H9.16_ENST00000403734.2_Frame_Shift_Del_p.L598fs	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	598					cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TTTTTCAGGCAAAGAGAAGTTG	0.441													31	48	---	---	---	---					
SLC3A2	6520	broad.mit.edu	37	11	62649529	62649529	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:62649529delA	ENST00000377892.1	+	6	1209	c.985delA	c.(985-987)aafs	p.K331fs	SLC3A2_ENST00000377889.2_Frame_Shift_Del_p.K238fs|SLC3A2_ENST00000377890.2_Frame_Shift_Del_p.K300fs|SLC3A2_ENST00000377891.2_Frame_Shift_Del_p.K301fs|SLC3A2_ENST00000538682.1_3'UTR|SLC3A2_ENST00000338663.7_Frame_Shift_Del_p.K199fs|SLC3A2_ENST00000536981.1_5'UTR|SLC3A2_ENST00000535296.1_Frame_Shift_Del_p.K269fs			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	300					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding	p.K331fs*31(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						GCAATCGGCTAAAAAAAAGAG	0.463													53	137	---	---	---	---					
TRIM49	57093	broad.mit.edu	37	11	89537226	89537226	+	Splice_Site	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:89537226delC	ENST00000329758.1	-	3	740		c.e3+1		TRIM49_ENST00000532501.2_Splice_Site	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49							intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CCATCACTTACCCGGTGTTCC	0.493													22	46	---	---	---	---					
KDM4D	55693	broad.mit.edu	37	11	94730807	94730807	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr11:94730807delA	ENST00000335080.5	+	3	1103	c.271delA	c.(271-273)aafs	p.K94fs	KDM4D_ENST00000536741.1_Frame_Shift_Del_p.K94fs	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	94	Poly-Lys.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TCAATACCATAAAAAAAAGAA	0.453													63	125	---	---	---	---					
SLC6A12	6539	broad.mit.edu	37	12	309834	309834	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:309834delC	ENST00000428720.1	-	7	1437	c.694delG	c.(694-696)tcfs	p.V232fs	SLC6A12_ENST00000424061.2_Frame_Shift_Del_p.V232fs|SLC6A12_ENST00000536824.1_Frame_Shift_Del_p.V232fs|SLC6A12_ENST00000538272.1_5'UTR|SLC6A12_ENST00000397296.2_Frame_Shift_Del_p.V232fs|SLC6A12_ENST00000359674.4_Frame_Shift_Del_p.V232fs	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	232					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GTGGACTTGACCCCCTTCCAG	0.622													92	190	---	---	---	---					
KCNA5	3741	broad.mit.edu	37	12	5155012	5155012	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:5155012delG	ENST00000252321.3	+	1	1928	c.1699delG	c.(1699-1701)ggfs	p.G568fs		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	568						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CTGCAAGGCTGGGGGGACCCT	0.632													9	34	---	---	---	---					
PRB4	5545	broad.mit.edu	37	12	11461543	11461543	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:11461543delG	ENST00000279575.1	-	3	407	c.374delC	c.(373-375)cafs	p.P125fs	PRB4_ENST00000535904.1_Frame_Shift_Del_p.P125fs|PRB4_ENST00000445719.2_Intron	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	188	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.		Missing (in allele M and allele S).			extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GCCTCCTTGTGGGGGTGGTCT	0.607										HNSCC(22;0.051)			12	1169	---	---	---	---					
GUCY2C	2984	broad.mit.edu	37	12	14781652	14781652	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:14781652delT	ENST00000261170.3	-	20	2313	c.2177delA	c.(2176-2178)acfs	p.N726fs		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	726	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTCCCAACAGTTTTTTACAAG	0.343													45	145	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56566385	56566385	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:56566385delT	ENST00000394023.3	-	19	1952	c.1847delA	c.(1846-1848)agfs	p.K616fs	SMARCC2_ENST00000347471.4_Frame_Shift_Del_p.K616fs|SMARCC2_ENST00000267064.4_Frame_Shift_Del_p.K585fs|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Frame_Shift_Del_p.K616fs	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	585	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGAACATTCTTTTTTGTGTA	0.498													59	128	---	---	---	---					
DTX3	196403	broad.mit.edu	37	12	58000848	58000848	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:58000848delC	ENST00000548198.1	+	3	1706	c.202delC	c.(202-204)ccfs	p.P69fs	DTX3_ENST00000548804.1_Frame_Shift_Del_p.P69fs|DTX3_ENST00000337737.3_Frame_Shift_Del_p.P69fs|DTX3_ENST00000551632.1_Frame_Shift_Del_p.P72fs			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	69					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					ACAGGGTCCTCCCCCGGCCCC	0.602													67	208	---	---	---	---					
DTX3	196403	broad.mit.edu	37	12	58001073	58001073	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:58001073delC	ENST00000548198.1	+	3	1931	c.427delC	c.(427-429)ccfs	p.P144fs	DTX3_ENST00000548804.1_Frame_Shift_Del_p.P144fs|DTX3_ENST00000337737.3_Frame_Shift_Del_p.P144fs|DTX3_ENST00000551632.1_Frame_Shift_Del_p.P147fs			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	144	Pro-rich.				Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					ccctcctcctccccccctgcc	0.697													4	8	---	---	---	---					
TMTC2	160335	broad.mit.edu	37	12	83444732	83444732	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:83444732delA	ENST00000549919.1	+	11	3989	c.2184delA	c.(2182-2184)gcfs	p.A728fs	TMTC2_ENST00000321196.3_Frame_Shift_Del_p.A734fs			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	734						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						CTGAGATGGCAAAAAAAGCAG	0.433													21	81	---	---	---	---					
KSR2	283455	broad.mit.edu	37	12	118199247	118199248	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:118199247_118199248insG	ENST00000425217.1	-	4	521_522	c.467_468insC	c.(466-468)cgafs	p.R156fs	KSR2_ENST00000339824.5_Frame_Shift_Ins_p.R185fs	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	185					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGTGGGCTCCGGGGGGCACAC	0.634													50	98	---	---	---	---					
GCN1L1	10985	broad.mit.edu	37	12	120591026	120591026	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:120591026delG	ENST00000300648.6	-	33	4065	c.4053delC	c.(4051-4053)ccfs	p.P1351fs		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1351					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTGCTGGGAGGGGGTGGAGA	0.602													18	91	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132537936	132537936	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr12:132537936delC	ENST00000333577.4	+	44	7739	c.7630delC	c.(7630-7632)ccfs	p.P2546fs	EP400_ENST00000389562.2_Frame_Shift_Del_p.P2509fs|EP400_ENST00000332482.4_Frame_Shift_Del_p.P2473fs|EP400_ENST00000330386.6_Frame_Shift_Del_p.P2429fs|EP400_ENST00000389561.2_Frame_Shift_Del_p.P2510fs			Q96L91	EP400_HUMAN	E1A binding protein p400	2546	Interaction with ZNF42 (By similarity).|Poly-Pro.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCCCAgccacccccgcccca	0.736													11	17	---	---	---	---					
ZMYM5	9205	broad.mit.edu	37	13	20398645	20398645	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:20398645delT	ENST00000337963.4	-	8	2246	c.1982delA	c.(1981-1983)atfs	p.N661fs		NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	661						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		cacaccatcatttttctcatt	0.323													21	41	---	---	---	---					
IFT88	8100	broad.mit.edu	37	13	21205180	21205180	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:21205180delA	ENST00000382778.4	+	17	2470	c.1352delA	c.(1351-1353)gafs	p.E451fs	IFT88_ENST00000537103.1_Frame_Shift_Del_p.E423fs|IFT88_ENST00000319980.6_Frame_Shift_Del_p.E451fs|IFT88_ENST00000351808.5_Frame_Shift_Del_p.E442fs|IFT88_ENST00000461115.1_3'UTR			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	451					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		AAAGTGTTGGAAAAAAAGGAC	0.363													87	154	---	---	---	---					
RFC3	5983	broad.mit.edu	37	13	34398063	34398063	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:34398063delA	ENST00000380071.3	+	3	365	c.235delA	c.(235-237)aafs	p.K81fs	RFC3_ENST00000434425.1_Frame_Shift_Del_p.K81fs	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	81					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		GACTCCATCTAAAAAAAAAAT	0.269													17	50	---	---	---	---					
MYCBP2	23077	broad.mit.edu	37	13	77759324	77759326	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:77759324_77759326delTAT	ENST00000407578.2	-	32	4897_4899	c.4631_4633delATA	c.(4630-4635)act>a	p.NT1544del	MYCBP2_ENST00000357337.6_In_Frame_Del_p.NT1506del|MYCBP2_ENST00000544440.2_In_Frame_Del_p.NT1506del|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCAGTGAAAGTATTATGACATTC	0.419													47	126	---	---	---	---					
LAMP1	3916	broad.mit.edu	37	13	113965071	113965071	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr13:113965071delA	ENST00000332556.4	+	4	645	c.451delA	c.(451-453)aafs	p.K152fs	LAMP1_ENST00000397181.3_Intron	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	152	First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AGATATAGATAAAAAATACAG	0.398													70	133	---	---	---	---					
SMEK1	55671	broad.mit.edu	37	14	91927912	91927913	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr14:91927912_91927913delTT	ENST00000554684.1	-	14	2660_2661	c.2164_2165delAA	c.(2164-2166)cfs	p.N722fs	SMEK1_ENST00000428424.2_Frame_Shift_Del_p.N496fs|SMEK1_ENST00000337238.4_Frame_Shift_Del_p.N722fs|SMEK1_ENST00000554943.1_Frame_Shift_Del_p.N735fs|SMEK1_ENST00000555718.1_5'UTR|SMEK1_ENST00000555462.1_Frame_Shift_Del_p.N496fs			Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	735						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		TCCAGAAAGGTTTGTTTTCAGA	0.421													220	104	---	---	---	---					
LOC283683	283683	broad.mit.edu	37	15	23114116	23114116	+	RNA	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:23114116delA	ENST00000557922.1	-	0	243					NR_040057.1																						TACATACCCTAAAAAAAAGCC	0.363													11	8	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299147	+	RNA	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:23299147delA	ENST00000560464.1	-	0	4510																											ACATTCAAAGAAAAAAAAAAA	0.313													5	4	---	---	---	---					
DNAJC17	55192	broad.mit.edu	37	15	41067229	41067231	+	Splice_Site	DEL	CTT	CTT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:41067229_41067231delCTT	ENST00000220496.4	-	8	628_630	c.600_splice	c.e8+1	p.K200_splice		NM_018163.2	NP_060633.1	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	200	RRM.				protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|skin(1)	6		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CAGGGCCGACCTTCTGCAAAAGC	0.488													29	67	---	---	---	---					
SCAPER	49855	broad.mit.edu	37	15	76958026	76958026	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr15:76958026delT	ENST00000538941.2	-	21	2814	c.1875delA	c.(1873-1875)aafs	p.K625fs	SCAPER_ENST00000324767.7_Frame_Shift_Del_p.K871fs|SCAPER_ENST00000563290.1_Frame_Shift_Del_p.K871fs	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	870	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						TCTTTTTGGCTTTTTTTTTAT	0.338													14	25	---	---	---	---					
CLDN6	9074	broad.mit.edu	37	16	3065456	3065456	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:3065456delC	ENST00000396925.1	-	3	995	c.567delG	c.(565-567)ggfs	p.G189fs	CLDN6_ENST00000328796.4_Frame_Shift_Del_p.G189fs|CLDN6_ENST00000572154.1_Intron			P56747	CLD6_HUMAN	claudin 6	189					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GGCCCTGGGACCCCCCCGAGG	0.642													21	57	---	---	---	---					
GRIN2A	2903	broad.mit.edu	37	16	9857380	9857380	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:9857380delT	ENST00000396573.2	-	14	4330	c.4021delA	c.(4021-4023)gcfs	p.S1342fs	GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000396575.2_Frame_Shift_Del_p.S1342fs|GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000330684.3_Frame_Shift_Del_p.S1342fs	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1342					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAAAGGGAGCTTTTTTTCCCC	0.542													51	114	---	---	---	---					
ACSM3	6296	broad.mit.edu	37	16	20796371	20796371	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:20796371delA	ENST00000289416.5	+	8	1560	c.1085delA	c.(1084-1086)gafs	p.E362fs	ACSM3_ENST00000440284.2_Frame_Shift_Del_p.E362fs|ACSM3_ENST00000567387.1_3'UTR|ERI2_ENST00000300005.3_Intron|ACSM3_ENST00000450120.2_Frame_Shift_Del_p.E354fs	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	362					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						GACGTGACTGAAAAATGGAGA	0.428													60	144	---	---	---	---					
PLK1	5347	broad.mit.edu	37	16	23690512	23690513	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:23690512_23690513delTC	ENST00000300093.4	+	1	370_371	c.259_260delTC	c.(259-261)tfs	p.S87fs	PLK1_ENST00000564202.1_3'UTR	NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	87	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		TGTGCCTAAGTCTCTGCTGCTC	0.584													12	24	---	---	---	---					
VPS35	55737	broad.mit.edu	37	16	46695735	46695735	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:46695735delT	ENST00000299138.7	-	16	2164	c.2106delA	c.(2104-2106)aafs	p.K702fs		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	702					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TTTTTAGAGCTTTTTTTAGGC	0.368													7	336	---	---	---	---					
SLC7A6	9057	broad.mit.edu	37	16	68321684	68321685	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:68321684_68321685insG	ENST00000566454.1	+	5	828_829	c.559_560insG	c.(559-561)gggfs	p.G187fs	SLC7A6_ENST00000219343.6_Frame_Shift_Ins_p.G187fs	NM_001076785.2	NP_001070253.1	Q92536	YLAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	187					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		CTATGTCAAGTGGGGCACACGT	0.540													49	106	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372597	74372597	+	RNA	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:74372597delA	ENST00000429810.2	-	0	1599																											TTCCCAGGACAAAAAAAAAAA	0.403													19	12	---	---	---	---					
ZDHHC7	55625	broad.mit.edu	37	16	85010045	85010045	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr16:85010045delC	ENST00000313732.4	-	8	1183	c.831delG	c.(829-831)ggfs	p.G277fs	ZDHHC7_ENST00000564466.1_Frame_Shift_Del_p.G314fs	NM_017740.2	NP_060210.2	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7	277						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(6)|lung(4)	10						GTGAGGGGGGCCCCCCAAAGA	0.577													37	68	---	---	---	---					
GP1BA	2811	broad.mit.edu	37	17	4837372	4837373	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:4837372_4837373insA	ENST00000329125.5	+	2	1548_1549	c.1473_1474insA	c.(1471-1476)acaaaafs	p.TK491fs		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	491								p.T494fs*59(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						TAGAATCCACCAAAAAAACCAT	0.500													44	82	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7748975	7748975	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:7748975delC	ENST00000254846.5	+	4	492	c.103delC	c.(103-105)ccfs	p.P37fs	KDM6B_ENST00000448097.2_Frame_Shift_Del_p.P37fs	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	37	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CCCGCCTCATCCCCCTCCTCG	0.657													59	150	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12626277	12626278	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:12626277_12626278insA	ENST00000425538.1	+	5	567_568	c.367_368insA	c.(367-369)aaafs	p.K123fs	MYOCD_ENST00000343344.4_Frame_Shift_Ins_p.K123fs|MYOCD_ENST00000395988.1_Frame_Shift_Ins_p.K27fs	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	123					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GGAGCTGGTGGAAAAAAACATT	0.470													55	192	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29664535	29664536	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:29664535_29664536delGA	ENST00000358273.4	+	43	6960_6961	c.6577_6578delGA	c.(6577-6579)gfs	p.E2193fs	NF1_ENST00000356175.3_Frame_Shift_Del_p.E2172fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2193					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)|p.E2193fs*48(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGCTCCTATGAGAGAGAGACT	0.421			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			55	148	---	---	---	---					
ACBD4	79777	broad.mit.edu	37	17	43214792	43214793	+	Frame_Shift_Ins	INS	-	-	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:43214792_43214793insC	ENST00000431281.1	+	8	942_943	c.473_474insC	c.(472-474)cccfs	p.P158fs	ACBD4_ENST00000321854.8_Frame_Shift_Ins_p.P158fs|ACBD4_ENST00000586346.1_Frame_Shift_Ins_p.P158fs|ACBD4_ENST00000591859.1_Frame_Shift_Ins_p.P158fs|ACBD4_ENST00000376955.4_Frame_Shift_Ins_p.P158fs|ACBD4_ENST00000591136.1_3'UTR|ACBD4_ENST00000398322.3_Frame_Shift_Ins_p.P158fs|ACBD4_ENST00000592162.1_Frame_Shift_Ins_p.P158fs	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	158							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						CCTCCCTGCCTCCCCAAGGAAC	0.629													18	43	---	---	---	---					
RPS6KB1	6198	broad.mit.edu	37	17	58012656	58012656	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:58012656delA	ENST00000225577.4	+	10	994	c.973delA	c.(973-975)aafs	p.K326fs	RPS6KB1_ENST00000443572.2_Frame_Shift_Del_p.K303fs|RPS6KB1_ENST00000393021.3_Frame_Shift_Del_p.K273fs|RPS6KB1_ENST00000406116.3_Frame_Shift_Del_p.K326fs	NM_001272042.1|NM_001272044.1|NM_001272060.1|NM_003161.2	NP_001258971.1|NP_001258973.1|NP_001258989.1|NP_003152.1	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 1	326	Protein kinase.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			AGATCTGCTTAAAAAGGTAAG	0.338													29	58	---	---	---	---					
HEATR6	63897	broad.mit.edu	37	17	58121377	58121378	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:58121377_58121378delCT	ENST00000184956.6	-	20	3108_3109	c.3092_3093delAG	c.(3091-3093)gfs	p.E1031fs	HEATR6_ENST00000585976.1_Frame_Shift_Del_p.E919fs	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	1031							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ACCCGTACTGCTCTCTCTTCCC	0.505													7	252	---	---	---	---					
INTS2	57508	broad.mit.edu	37	17	59999160	59999160	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:59999160delA	ENST00000444766.3	-	4	560	c.485delT	c.(484-486)tcfs	p.F162fs	INTS2_ENST00000251334.6_Frame_Shift_Del_p.F154fs	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	162					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						AGAAGACTTGAAAAAAAATTC	0.299													29	97	---	---	---	---					
STRADA	92335	broad.mit.edu	37	17	61781804	61781804	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:61781804delG	ENST00000392950.4	-	9	1159	c.886delC	c.(886-888)ggfs	p.R296fs	STRADA_ENST00000579340.1_3'UTR|STRADA_ENST00000447001.3_Frame_Shift_Del_p.R289fs|STRADA_ENST00000245865.5_3'UTR|RP11-51F16.8_ENST00000580553.1_3'UTR|STRADA_ENST00000580039.1_5'UTR|STRADA_ENST00000336174.6_Frame_Shift_Del_p.R333fs|STRADA_ENST00000375840.4_Frame_Shift_Del_p.R275fs|STRADA_ENST00000582137.1_Frame_Shift_Del_p.R304fs	NM_001003786.2|NM_001165969.1|NM_153335.5	NP_001003786.1|NP_001159441.1|NP_699166.2	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha	333	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(2)	13						TTGGAGGGCCGGGGGGTGCTG	0.647													18	42	---	---	---	---					
UBE2O	63893	broad.mit.edu	37	17	74394955	74394957	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:74394955_74394957delGTT	ENST00000319380.7	-	10	1808_1810	c.1744_1746delAAC	c.(1744-1746)del	p.N582del	UBE2O_ENST00000587581.1_5'UTR	NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	582							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						GGCAGAACTCGTTGTTGTCCAGG	0.611													7	345	---	---	---	---					
SOCS3	9021	broad.mit.edu	37	17	76354878	76354878	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr17:76354878delC	ENST00000330871.2	-	2	714	c.299delG	c.(298-300)gcfs	p.G100fs		NM_003955.3	NP_003946.3	O14543	SOCS3_HUMAN	suppressor of cytokine signaling 3	100	SH2.				anti-apoptosis|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	protein kinase inhibitor activity			kidney(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(99;0.000688)|OV - Ovarian serous cystadenocarcinoma(97;0.0554)			AGAGAAGCTGCCCCCCTCACA	0.647													8	25	---	---	---	---					
PIGN	23556	broad.mit.edu	37	18	59814310	59814310	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:59814310delT	ENST00000357637.5	-	9	1114	c.699delA	c.(697-699)aafs	p.K233fs	PIGN_ENST00000400334.3_Frame_Shift_Del_p.K233fs	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	233					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				CATCATCAACTTTTTTAATAT	0.303													22	36	---	---	---	---					
ADNP2	22850	broad.mit.edu	37	18	77895513	77895513	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr18:77895513delA	ENST00000262198.4	+	4	2672	c.2217delA	c.(2215-2217)ctfs	p.L739fs		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	739					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CACCATTTCTAAAGTGGATGA	0.502													77	136	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9059693	9059701	+	In_Frame_Del	DEL	TGTGGCCTT	TGTGGCCTT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:9059693_9059701delTGTGGCCTT	ENST00000397910.4	-	3	27948_27956	c.27745_27753delAAGGCCACA	c.(27745-27753)del	p.KAT9249del		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9251	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATTGAAGATGTGGCCTTTGTTGTCACT	0.450													37	53	---	---	---	---					
PDE4C	5143	broad.mit.edu	37	19	18329753	18329753	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:18329753delA	ENST00000355502.3	-	13	1933	c.1062delT	c.(1060-1062)ttfs	p.F354fs	PDE4C_ENST00000447275.2_Frame_Shift_Del_p.F248fs|PDE4C_ENST00000594617.2_Frame_Shift_Del_p.F354fs|PDE4C_ENST00000262805.11_Frame_Shift_Del_p.F322fs|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000539010.1_Frame_Shift_Del_p.F123fs|PDE4C_ENST00000594465.2_Frame_Shift_Del_p.F354fs			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	354					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TAGGTACCTGAAAAATGCTGA	0.507													53	98	---	---	---	---					
CRTC1	23373	broad.mit.edu	37	19	18887993	18887993	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:18887993delC	ENST00000338797.6	+	15	1779	c.1754delC	c.(1753-1755)tcfs	p.S585fs	CRTC1_ENST00000321949.8_Frame_Shift_Del_p.S569fs|CRTC1_ENST00000601916.1_Frame_Shift_Del_p.S327fs|CRTC1_ENST00000594658.1_Frame_Shift_Del_p.S528fs	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	569					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding	p.S572fs*6(2)	CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						ACAGGAGAGTCCCCCCCCAGC	0.637													29	49	---	---	---	---					
ZFP82	284406	broad.mit.edu	37	19	36883652	36883655	+	Frame_Shift_Del	DEL	TACA	TACA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:36883652_36883655delTACA	ENST00000392161.3	-	5	1829_1832	c.1587_1590delTGTA	c.(1585-1590)aafs	p.NV529fs	ZFP82_ENST00000392171.1_Frame_Shift_Del_p.NV529fs	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CTTAGATTTTTACATTATGAATTT	0.333													35	66	---	---	---	---					
PLEKHG2	64857	broad.mit.edu	37	19	39914446	39914446	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:39914446delC	ENST00000425673.1	+	17	2911	c.2586delC	c.(2584-2586)gtfs	p.V862fs	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Frame_Shift_Del_p.V832fs|PLEKHG2_ENST00000409794.3_Frame_Shift_Del_p.V891fs|PLEKHG2_ENST00000378550.1_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	891					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGAGTCTGTCCCCCTGGGTC	0.572													41	62	---	---	---	---					
CD3EAP	10849	broad.mit.edu	37	19	45911859	45911861	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:45911859_45911861delGAA	ENST00000309424.3	+	3	1121_1123	c.633_635delGAA	c.(631-636)cgg>cg	p.RK211del	ERCC1_ENST00000300853.3_3'UTR|ERCC1_ENST00000423698.2_3'UTR|CD3EAP_ENST00000589804.1_In_Frame_Del_p.RK213del	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	211					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		TGGATGTGCGGAAGAAGAAGAAG	0.581													7	177	---	---	---	---					
PPFIA3	8541	broad.mit.edu	37	19	49641637	49641637	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:49641637delC	ENST00000334186.4	+	16	2378	c.2029delC	c.(2029-2031)ccfs	p.P677fs	PPFIA3_ENST00000602351.1_Frame_Shift_Del_p.P677fs	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	677						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCACTCAACACCCCGCCTGGC	0.682													17	77	---	---	---	---					
TBC1D17	79735	broad.mit.edu	37	19	50381462	50381465	+	Frame_Shift_Del	DEL	CTCT	CTCT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:50381462_50381465delCTCT	ENST00000221543.5	+	2	383_386	c.84_87delCTCT	c.(82-87)gafs	p.DS28fs	TBC1D17_ENST00000535102.2_Intron|TBC1D17_ENST00000598789.1_3'UTR|AKT1S1_ENST00000482622.1_5'UTR	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	28						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		AGGACCGAGACTCTCTCATCGCTG	0.642													4	9	---	---	---	---					
CNOT3	4849	broad.mit.edu	37	19	54651965	54651966	+	Frame_Shift_Ins	INS	-	-	C			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr19:54651965_54651966insC	ENST00000406403.1	+	10	2580_2581	c.977_978insC	c.(976-978)gccfs	p.A326fs	CNOT3_ENST00000358389.3_Frame_Shift_Ins_p.A145fs|CNOT3_ENST00000221232.5_Frame_Shift_Ins_p.A326fs			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	326	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TACCCCTCCGGCCCCCCGCCTG	0.693													5	5	---	---	---	---					
LRRN4	164312	broad.mit.edu	37	20	6025250	6025250	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:6025250delG	ENST00000378858.4	-	4	1161	c.937delC	c.(937-939)tcfs	p.L313fs		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	313						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						CTGCAAGTGAGGGGGTTGCCA	0.478													14	48	---	---	---	---					
CPNE1	8904	broad.mit.edu	37	20	34219276	34219277	+	Splice_Site	DEL	CC	CC	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:34219276_34219277delCC	ENST00000317619.3	-	11	1109	c.714_splice	c.e11-1	p.239_splice	CPNE1_ENST00000317677.5_Splice_Site_p.244_splice|CPNE1_ENST00000397442.1_Splice_Site_p.239_splice|CPNE1_ENST00000397446.1_Splice_Site_p.239_splice|CPNE1_ENST00000397443.1_Splice_Site_p.239_splice|CPNE1_ENST00000397445.1_Splice_Site_p.239_splice|CPNE1_ENST00000352393.4_Splice_Site_p.239_splice			Q99829	CPNE1_HUMAN	copine I	239					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TCAAACTCAGCCTGGTGAGGAC	0.470													43	137	---	---	---	---					
TTI1	9675	broad.mit.edu	37	20	36627613	36627613	+	Frame_Shift_Del	DEL	G	G	-	rs149568606		TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:36627613delG	ENST00000373448.2	-	6	3008	c.2770delC	c.(2770-2772)tgfs	p.L924fs	TTI1_ENST00000449821.1_Frame_Shift_Del_p.L924fs|TTI1_ENST00000373447.3_Frame_Shift_Del_p.L924fs	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	924							binding	p.L924fs*37(1)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AGCACTGCCAGGGGGGCGTCC	0.577													29	105	---	---	---	---					
PPP1R16B	26051	broad.mit.edu	37	20	37547271	37547272	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:37547271_37547272delAT	ENST00000299824.1	+	11	1855_1856	c.1666_1667delAT	c.(1666-1668)gfs	p.M556fs	PPP1R16B_ENST00000373331.2_Frame_Shift_Del_p.M514fs	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	556					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				CATAGAGGAGATGGAGGAGAAG	0.574													15	55	---	---	---	---					
NFATC2	4773	broad.mit.edu	37	20	50140530	50140531	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:50140530_50140531insG	ENST00000371564.3	-	2	468_469	c.249_250insC	c.(247-252)ccgccgfs	p.P84fs	NFATC2_ENST00000396009.3_Frame_Shift_Ins_p.P84fs|NFATC2_ENST00000414705.1_Frame_Shift_Ins_p.P64fs	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	84					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CCGAATCGGCCGGGGGGCTCGC	0.663													23	111	---	---	---	---					
RBBP8NL	140893	broad.mit.edu	37	20	60989485	60989485	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr20:60989485delG	ENST00000252998.1	-	10	1078	c.922delC	c.(922-924)tgfs	p.L308fs		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		GCAGGGGCCAGGGGGCTGCTG	0.697													7	6	---	---	---	---					
ZNF280B	140883	broad.mit.edu	37	22	22842771	22842771	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:22842771delT	ENST00000360412.2	-	4	1728	c.953delA	c.(952-954)atfs	p.N318fs	ZNF280B_ENST00000406426.1_Frame_Shift_Del_p.N318fs	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AAACTTAACATTTTTTAGAAC	0.463													17	243	---	---	---	---					
EIF3L	51386	broad.mit.edu	37	22	38258975	38258975	+	Splice_Site	DEL	G	G	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:38258975delG	ENST00000412331.2	+	6	1017		c.e6-1		EIF3L_ENST00000381683.6_Intron|EIF3L_ENST00000476955.1_Intron|EIF3L_ENST00000406934.1_Splice_Site	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L							eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TTTCTTTACAGGGGGGACCTT	0.383													69	55	---	---	---	---					
CELSR1	9620	broad.mit.edu	37	22	46931227	46931227	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chr22:46931227delC	ENST00000262738.3	-	1	1840	c.1841delG	c.(1840-1842)gcfs	p.G615fs	CELSR1_ENST00000395964.1_Frame_Shift_Del_p.G615fs	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	615	Cadherin 4.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGCGCTGCCGCCCCCCAGAAA	0.657													19	18	---	---	---	---					
RPGR	6103	broad.mit.edu	37	X	38145101	38145101	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:38145101delC	ENST00000378505.2	-	15	3327	c.3151delG	c.(3151-3153)aafs	p.E1051fs	RPGR_ENST00000342811.3_Intron|RPGR_ENST00000309513.3_Intron|RPGR_ENST00000339363.3_Intron|RPGR_ENST00000338898.3_Intron|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000318842.7_Intron	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	840					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						tcttctccttccccctccttt	0.542													44	50	---	---	---	---					
GABRQ	55879	broad.mit.edu	37	X	151821591	151821591	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:151821591delC	ENST00000370306.2	+	9	1766	c.1746delC	c.(1744-1746)tgfs	p.C582fs		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	582						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					AGGATAGTTGCCCCCCAAGCC	0.517													50	76	---	---	---	---					
BRCC3	79184	broad.mit.edu	37	X	154344352	154344353	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B0-5098-01A-01D-1421-08	TCGA-B0-5098-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d1d2022-4a61-4652-9f0c-8c92dfcb6d38	6b061e59-9fc8-4777-89ea-8887bfbba9c1	g.chrX:154344352_154344353insA	ENST00000369462.1	+	9	669_670	c.644_645insA	c.(643-645)catfs	p.H215fs	BRCC3_ENST00000369459.2_Intron|BRCC3_ENST00000330045.7_Frame_Shift_Ins_p.H190fs|BRCC3_ENST00000340647.4_Frame_Shift_Ins_p.H191fs|BRCC3_ENST00000399042.1_Frame_Shift_Ins_p.H215fs|MTCP1_ENST00000362018.2_Intron	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	215					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCGAAATCCCAATCCATATTG	0.436													36	27	---	---	---	---