Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC181	57821	broad.mit.edu	37	1	169390975	169390975	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:169390975C>G	ENST00000545005.1	-	4	1201	c.694G>C	c.(694-696)Gac>Cac	p.D232H	CCDC181_ENST00000367806.3_Missense_Mutation_p.D232H|CCDC181_ENST00000367805.3_Missense_Mutation_p.D232H|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		CTGGCAATGTCTTGTAAATTC	0.408000													13	206					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53522428	53522428	+	Missense_Mutation	SNP	C	C	T	rs143188831		TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:53522428C>T	ENST00000357758.3	-	10	2378	c.2195G>A	c.(2194-2196)cGc>cAc	p.R732H	DDHD1_ENST00000323669.5_Missense_Mutation_p.R732H|DDHD1_ENST00000395606.1_Missense_Mutation_p.R739H	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	732	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					ATAGTGTCGGCGGGACAAAAC	0.403000													5	326					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30643271	30643271	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr17:30643271C>T	ENST00000269051.4	+	8	917	c.903C>T	c.(901-903)tgC>tgT	p.C301C	RHBDL3_ENST00000536287.1_Silent_p.C203C|RHBDL3_ENST00000538145.1_Silent_p.C293C	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	301					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				GCATGAAGTGCCAGTTCAAGC	0.522000													5	316					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769744	140769744	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr5:140769744C>G	ENST00000519479.1	+	1	2293	c.2293C>G	c.(2293-2295)Cta>Gta	p.L765V	PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTAATTTCCTAAAATGTAG	0.433000													203	282					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516104	195516104	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr3:195516104C>T	ENST00000463781.3	-	2	2806	c.2347G>A	c.(2347-2349)Gga>Aga	p.G783R	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.G783R|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	788					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGTTTGTCCAGAGGCCTCT	0.622000													34	68					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24202093	24202093	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:24202093C>A	ENST00000536471.1	-	3	273	c.15G>T	c.(13-15)tgG>tgT	p.W5C	CNR2_ENST00000374472.4_Missense_Mutation_p.W5C			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	5					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TCTCTGTCACCCAGCATTCCT	0.473000													80	131					7.30829e-53	8.00908e-53	1	1	0
DPYSL4	10570	broad.mit.edu	37	10	134016279	134016279	+	Missense_Mutation	SNP	C	C	T	rs143213280		TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr10:134016279C>T	ENST00000338492.4	+	12	1575	c.1411C>T	c.(1411-1413)Cgg>Tgg	p.R471W	DPYSL4_ENST00000368627.1_Intron|DPYSL4_ENST00000368629.1_Intron	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	471					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CTTCGTCCCTCGGAAAACATT	0.642000													7	83					0	0	1	0	0
PGF	5228	broad.mit.edu	37	14	75420625	75420625	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:75420625C>T	ENST00000555567.1	-	2	641	c.100G>A	c.(100-102)Ggc>Agc	p.G34S	PGF_ENST00000553716.1_Missense_Mutation_p.G34S|PGF_ENST00000238607.6_Missense_Mutation_p.G33S|PGF_ENST00000405431.2_Missense_Mutation_p.G34S	NM_002632.5	NP_002623.2	P49763	PLGF_HUMAN	placental growth factor	34					angiogenesis|cell differentiation|cell-cell signaling|positive regulation of cell division|positive regulation of cell proliferation|vascular endothelial growth factor receptor signaling pathway	extracellular region|membrane	growth factor activity|heparin binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(234;0.00668)		TCTGACGAGCCGTTCCCAGCA	0.597000													4	45					0	0	1	0	0
PSMD13	5719	broad.mit.edu	37	11	250865	250865	+	Splice_Site	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:250865G>A	ENST00000532097.1	+	10	1341	c.837_splice	c.e10+1	p.E279_splice	PSMD13_ENST00000352303.5_Splice_Site_p.E279_splice|PSMD13_ENST00000431206.2_Splice_Site_p.E281_splice	NM_002817.3	NP_002808.3	Q9UNM6	PSD13_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	279	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	10		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.79e-27)|Epithelial(43;4e-26)|OV - Ovarian serous cystadenocarcinoma(40;6.02e-21)|BRCA - Breast invasive adenocarcinoma(625;3.93e-05)|Lung(200;0.112)|LUSC - Lung squamous cell carcinoma(625;0.129)		GCCTCATGGAGGTAAGCGAAC	0.478000											OREG0020657	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	186					0	0	1	0	0
YPEL2	388403	broad.mit.edu	37	17	57466804	57466804	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr17:57466804G>A	ENST00000312655.4	+	4	563	c.245G>A	c.(244-246)tGc>tAc	p.C82Y	YPEL2_ENST00000585166.1_Missense_Mutation_p.C82Y|YPEL2_ENST00000581865.1_3'UTR	NM_001005404.3	NP_001005404.1	Q96QA6	YPEL2_HUMAN	yippee-like 2 (Drosophila)	82						nucleolus				endometrium(1)|large_intestine(1)|lung(3)	5	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TGTGAAAACTGCAAAACCACT	0.483000													3	52					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71971760	71971760	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr12:71971760C>T	ENST00000266674.5	+	14	1575	c.1264C>T	c.(1264-1266)Cca>Tca	p.P422S	LGR5_ENST00000540815.2_Missense_Mutation_p.P398S|LGR5_ENST00000536515.1_Missense_Mutation_p.P350S			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	422						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTCCACTTTGCCATCCCTAAT	0.313000													5	306					0	0	1	0	0
CCDC89	220388	broad.mit.edu	37	11	85396245	85396245	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:85396245G>A	ENST00000316398.3	-	1	1075	c.929C>T	c.(928-930)gCg>gTg	p.A310V		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	310						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CCGCTCCAGCGCATGCTTCCT	0.512000													4	180					0	0	1	0	0
ZG16B	124220	broad.mit.edu	37	16	2882103	2882103	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr16:2882103G>A	ENST00000382280.3	+	4	649	c.570G>A	c.(568-570)ccG>ccA	p.P190P	ZG16B_ENST00000572863.1_Silent_p.P160P	NM_145252.2	NP_660295.2	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16B	190						extracellular region	sugar binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5						TAGAGGAGCCGACCACTGAGC	0.562000													5	110					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9248274	9248274	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr12:9248274T>C	ENST00000318602.7	-	16	2181	c.1874A>G	c.(1873-1875)aAg>aGg	p.K625R		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	625					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	AGTGAGGTCCTTTTCTGGTAG	0.353000													3	233					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089264	86089264	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:86089264G>A	ENST00000330753.4	+	2	2173	c.1406G>A	c.(1405-1407)cGc>cAc	p.R469H	FLRT2_ENST00000554746.1_Missense_Mutation_p.R469H	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	469	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTTCAGGAGCGCATAGTCAGC	0.507000													4	248					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	7					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23239116	23239116	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:23239116G>A	ENST00000358043.5	+	4	826	c.508G>A	c.(508-510)Gcc>Acc	p.A170T	OXA1L_ENST00000604262.1_Missense_Mutation_p.A186T|OXA1L_ENST00000285848.5_Missense_Mutation_p.A246T|OXA1L_ENST00000412791.1_Missense_Mutation_p.A186T			Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	186					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AATCAGAGAGGCCAAGTTAGC	0.507000													39	1608					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48839848	48839848	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr8:48839848T>G	ENST00000314191.2	-	21	2381	c.2325A>C	c.(2323-2325)gaA>gaC	p.E775D	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.E775D	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	775					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AAATTGACCATTCTTCTAGAG	0.428000								Non-homologous end-joining					3	76					0	0	1	0	0
WDPCP	51057	broad.mit.edu	37	2	63666932	63666932	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr2:63666932C>T	ENST00000409562.3	-	7	704	c.458G>A	c.(457-459)aGa>aAa	p.R153K	WDPCP_ENST00000409120.1_5'UTR|WDPCP_ENST00000409199.1_Intron|WDPCP_ENST00000272321.7_Missense_Mutation_p.R153K|WDPCP_ENST00000409835.1_5'UTR			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	153					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						CACCAGGCTTCTGTCAATCAC	0.498000													5	238					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18778612	18778612	+	RNA	SNP	C	C	T	rs1055042	by1000genomes	TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:18778612C>T	ENST00000412448.1	-	0	793																											GCGGCCACGGCAGCCCTGGTG	0.637000													3	17					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12381877	12381877	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:12381877C>T	ENST00000358136.3	+	33	7690	c.7560C>T	c.(7558-7560)tgC>tgT	p.C2520C	VPS13D_ENST00000356315.4_Silent_p.C2520C	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2520					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTTTTCATGCCGACTAGGGA	0.408000													4	204					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12160774	12160774	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr10:12160774G>A	ENST00000263035.4	+	15	2491	c.2429G>A	c.(2428-2430)gGc>gAc	p.G810D		NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	810					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.G810D(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TTCTGCTCCGGCAAACATTTC	0.483000													5	465					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501914	140501914	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr5:140501914C>T	ENST00000194152.1	+	1	334	c.334C>T	c.(334-336)Ccg>Tcg	p.P112S		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		112	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGGAAATGCCGGTGCAATT	0.423000													4	96					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012658	6012658	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr9:6012658T>G	ENST00000259569.5	-	1	2960	c.2950A>C	c.(2950-2952)Ata>Cta	p.I984L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	984					protein transport	cytoplasm|nucleus	binding	p.I984L(4)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTCCCTATTGCTGAGATA	0.363000													5	241					0	0	1	0	0
LCE1B	353132	broad.mit.edu	37	1	152785009	152785009	+	Silent	SNP	C	C	T	rs151038984		TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:152785009C>T	ENST00000360090.3	+	1	563	c.87C>T	c.(85-87)tgC>tgT	p.C29C		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	29	Pro-rich.				keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCTAGATGCCCCCCAAAGT	0.632000													4	146					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128471384	128471384	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr2:128471384G>A	ENST00000322313.4	-	18	3239	c.3081C>T	c.(3079-3081)caC>caT	p.H1027H		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1027					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CACGTAACCGGTGGCCAAAGC	0.607000													6	258					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112015631	112015631	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr6:112015631G>A	ENST00000354650.3	-	12	1826	c.1220C>T	c.(1219-1221)gCt>gTt	p.A407V	FYN_ENST00000538466.1_Missense_Mutation_p.A404V|FYN_ENST00000229470.5_Missense_Mutation_p.A355V|FYN_ENST00000229471.4_Missense_Mutation_p.A352V|FYN_ENST00000356013.2_Missense_Mutation_p.A352V|FYN_ENST00000368678.4_Missense_Mutation_p.A404V|FYN_ENST00000368682.3_Missense_Mutation_p.A404V|FYN_ENST00000368667.2_Missense_Mutation_p.A407V	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	407	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCCGAAGTCAGCAATCTTGCA	0.468000													4	321					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853645	42853645	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr12:42853645T>C	ENST00000455697.1	-	8	2747	c.2462A>G	c.(2461-2463)aAg>aGg	p.K821R	PRICKLE1_ENST00000548696.1_Missense_Mutation_p.K821R|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.K821R|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.K821R|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.K821R|RP11-328C8.4_ENST00000547824.1_RNA	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	821	Poly-Lys.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CTTGTGTCCCTTTTTCTTCTT	0.403000													5	490					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457994	124457994	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr10:124457994C>T	ENST00000329446.4	-	3	294	c.263G>A	c.(262-264)gGc>gAc	p.G88D		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	88										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				GGTGTGAATGCCACCTAGACG	0.488000													5	438					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	7					0.115264	0.118219	1	1	0
HERC2	8924	broad.mit.edu	37	15	28386944	28386944	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr15:28386944C>A	ENST00000261609.7	-	77	11857	c.11749G>T	c.(11749-11751)Gtt>Ttt	p.V3917F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3917					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCATGCAGAACATCCATGTTT	0.338000													5	478					8.12818e-05	8.67006e-05	1	1	0
ZNF70	7621	broad.mit.edu	37	22	24087079	24087079	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:24087079G>A	ENST00000341976.3	-	2	709	c.249C>T	c.(247-249)acC>acT	p.T83T		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	83						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						CCTGGGGTCTGGTTCCTGGGG	0.498000													8	238					0	0	1	0	0
C10orf54	64115	broad.mit.edu	37	10	73511020	73511020	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr10:73511020T>C	ENST00000394957.3	-	7	984	c.926A>G	c.(925-927)gAg>gGg	p.E309G	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	309						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CTAGATGACCTCAAAGTTTGG	0.622000													2	8					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53304169	53304169	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:53304169C>T	ENST00000438150.2	-	2	1663	c.770G>A	c.(769-771)cGc>cAc	p.R257H	ZNF28_ENST00000414252.2_Missense_Mutation_p.R257H|ZNF28_ENST00000360272.4_Missense_Mutation_p.R257H|ZNF28_ENST00000457749.2_Missense_Mutation_p.R310H			P17035	ZNF28_HUMAN	zinc finger protein 28	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GTGTGATTTGCGACTGAAAAC	0.383000													6	376					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64920038	64920038	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr5:64920038C>T	ENST00000231524.9	-	1	435	c.64G>A	c.(64-66)Ggg>Agg	p.G22R	TRIM23_ENST00000381018.3_Missense_Mutation_p.G22R|TRIM23_ENST00000274327.7_Missense_Mutation_p.G22R	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	22					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		ACAGCTGTCCCCCGGCTGCCC	0.632000													4	22					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69377539	69377539	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr16:69377539C>T	ENST00000288025.3	-	4	549	c.494G>A	c.(493-495)gGc>gAc	p.G165D	RP11-343C2.7_ENST00000564737.1_Intron|RP11-343C2.9_ENST00000563634.1_Intron	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	165					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						CTTTTGTGTGCCGTCCTATGA	0.428000													4	179					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187725	57187725	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr7:57187725G>T	ENST00000331162.4	-	5	1667	c.1397C>A	c.(1396-1398)aCa>aAa	p.T466K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATGTGTAGGGTCT	0.428000													4	299					0.150653	0.15256	1	1	0
SEZ6L	23544	broad.mit.edu	37	22	26709759	26709759	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:26709759G>T	ENST00000529632.2	+	9	2102	c.1906G>T	c.(1906-1908)Gct>Tct	p.A636S	SEZ6L_ENST00000360929.3_Missense_Mutation_p.A636S|SEZ6L_ENST00000343706.4_Missense_Mutation_p.A636S|SEZ6L_ENST00000402979.1_Missense_Mutation_p.A409S|SEZ6L_ENST00000248933.6_Missense_Mutation_p.A636S|SEZ6L_ENST00000404234.3_Missense_Mutation_p.A636S|SEZ6L_ENST00000403121.1_Missense_Mutation_p.A409S	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	636	CUB 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CTCTGCTGTGGCTGGGGTGGT	0.502000													7	262					0.0293803	0.0309267	1	1	0
IRX5	10265	broad.mit.edu	37	16	54966805	54966805	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr16:54966805C>T	ENST00000394636.4	+	2	982	c.645C>T	c.(643-645)ggC>ggT	p.G215G	IRX5_ENST00000320990.5_Silent_p.G215G|IRX5_ENST00000560154.1_Intron|IRX5_ENST00000558597.1_Silent_p.G149G			P78411	IRX5_HUMAN	iroquois homeobox 5	215					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						ACCCCGAGGGCCCCGAAGCAG	0.647000													6	150					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67926348	67926348	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:67926348G>A	ENST00000304363.4	-	11	1818	c.1465C>T	c.(1465-1467)Ccc>Tcc	p.P489S		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.P489S(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						TTTTTAATGGGCAAATTTTTA	0.458000													4	168					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1954983	1954983	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr4:1954983C>T	ENST00000382888.3	+	2	632	c.114C>T	c.(112-114)ggC>ggT	p.G38G	WHSC1_ENST00000482415.2_Intron|WHSC1_ENST00000382891.5_Intron|WHSC1_ENST00000382892.2_Intron|WHSC1_ENST00000508803.1_Intron|WHSC1_ENST00000382895.3_Intron			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1258					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		ATTTTAGTGGCTCAGAACTGC	0.448000			T	IGH@	MM								6	33					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161140729	161140729	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:161140729G>A	ENST00000367999.4	+	12	1547	c.1281G>A	c.(1279-1281)tgG>tgA	p.W427*	PPOX_ENST00000495483.1_Intron|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000544598.1_Nonsense_Mutation_p.W135*|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000352210.5_Nonsense_Mutation_p.W427*	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	427					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity	p.W427*(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TAGGTCACTGGCAAAAACTAG	0.478000													4	228					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117248669	117248669	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr6:117248669C>T	ENST00000332958.2	+	17	2381	c.2365C>T	c.(2365-2367)Caa>Taa	p.Q789*		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	789					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TGCCAGCTGCCAAGGAGCAAC	0.418000													9	71					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5626669	5626669	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:5626669G>C	ENST00000380097.3	+	4	948	c.706G>C	c.(706-708)Gaa>Caa	p.E236Q	TRIM6_ENST00000507320.1_Missense_Mutation_p.E33Q|TRIM6_ENST00000515022.1_Missense_Mutation_p.E33Q|TRIM6-TRIM34_ENST00000354852.5_Missense_Mutation_p.E236Q|TRIM6_ENST00000506134.1_Missense_Mutation_p.E33Q|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000278302.5_Missense_Mutation_p.E208Q|TRIM6_ENST00000380107.1_Missense_Mutation_p.E182Q|TRIM6_ENST00000445329.1_Missense_Mutation_p.E33Q|HBG2_ENST00000380259.2_Intron	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCTGGAACAGGAAGAGAAGAA	0.512000											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	131					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118624114	118624114	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:118624114G>A	ENST00000336338.5	-	14	1979	c.1914C>T	c.(1912-1914)aaC>aaT	p.N638N		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	638						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ATCTGGCAGGGTTGTCCCACG	0.448000													12	225					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142275326	142275326	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr3:142275326G>A	ENST00000350721.4	-	9	2098	c.1977C>T	c.(1975-1977)gcC>gcT	p.A659A	ATR_ENST00000383101.3_Silent_p.A595A	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	659					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGCTCTGCAGGGCCCAGTTGT	0.423000								Other conserved DNA damage response genes					5	330					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545934	28545934	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr17:28545934G>A	ENST00000401766.2	-	3	871	c.359C>T	c.(358-360)cCc>cTc	p.P120L	SLC6A4_ENST00000261707.3_Missense_Mutation_p.P120L			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	120					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GATGGTGTAGGGGAGGAGGAA	0.512000													4	111					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36614565	36614565	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:36614565C>T	ENST00000311485.3	-	2	1315	c.1154G>A	c.(1153-1155)tGt>tAt	p.C385Y		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	385					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				TGCACTGAAACAAAATTCTTC	0.383000									Familial Hemophagocytic Lymphohistiocytosis				7	249					0	0	1	0	0
ZMYM2	7750	broad.mit.edu	37	13	20577188	20577188	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr13:20577188G>A	ENST00000382869.3	+	4	1297	c.1046G>A	c.(1045-1047)gGa>gAa	p.G349E	ZMYM2_ENST00000382871.2_Missense_Mutation_p.G349E|ZMYM2_ENST00000382881.3_Missense_Mutation_p.G262E|ZMYM2_ENST00000382874.2_Missense_Mutation_p.G349E	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAACGAAAAGGATCAGCTCAC	0.443000													4	70					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100380607	100380607	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:100380607G>A	ENST00000262233.6	+	14	1725	c.1586G>A	c.(1585-1587)gGc>gAc	p.G529D	EML1_ENST00000327921.9_Missense_Mutation_p.G517D|EML1_ENST00000334192.4_Missense_Mutation_p.G548D	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	529						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GTCCTGCAGGGCACTCTGTCA	0.502000													4	175					0	0	1	0	0
GPR52	9293	broad.mit.edu	37	1	174417939	174417939	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr1:174417939C>T	ENST00000367685.2	+	1	728	c.690C>T	c.(688-690)tgC>tgT	p.C230C	RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron|RABGAP1L_ENST00000357444.6_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	230						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						TCAAAATTTGCCGTCAGCACA	0.463000													4	306					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25780777	25780777	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr4:25780777C>T	ENST00000399878.3	-	16	2628	c.2506G>A	c.(2506-2508)Gaa>Aaa	p.E836K	SEL1L3_ENST00000264868.5_Missense_Mutation_p.E801K|SEL1L3_ENST00000502949.1_Missense_Mutation_p.E683K	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	836						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						AAGGTCCCTTCCATGTGTCCA	0.468000													14	200					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35763134	35763134	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr3:35763134C>T	ENST00000187397.4	+	14	1489	c.1033C>T	c.(1033-1035)Cga>Tga	p.R345*	ARPP21_ENST00000417925.1_Nonsense_Mutation_p.R311*|ARPP21_ENST00000458225.1_Nonsense_Mutation_p.R311*|ARPP21_ENST00000444190.1_Nonsense_Mutation_p.R291*|ARPP21_ENST00000337271.5_Nonsense_Mutation_p.R291*	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	345	Ser-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATCTGGGAGTCGACAGAGCAG	0.532000													4	45					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38946385	38946385	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:38946385C>T	ENST00000355481.4	+	16	1916	c.1785C>T	c.(1783-1785)aaC>aaT	p.N595N	RYR1_ENST00000359596.3_Silent_p.N595N|RYR1_ENST00000360985.3_Silent_p.N595N	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	595	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ATGGGAGGAACCACAAGGTCG	0.557000													4	69					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1954982	1954982	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr4:1954982G>C	ENST00000382888.3	+	2	631	c.113G>C	c.(112-114)gGc>gCc	p.G38A	WHSC1_ENST00000482415.2_Intron|WHSC1_ENST00000382891.5_Intron|WHSC1_ENST00000382892.2_Intron|WHSC1_ENST00000508803.1_Intron|WHSC1_ENST00000382895.3_Intron			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1258					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GATTTTAGTGGCTCAGAACTG	0.448000			T	IGH@	MM								6	32					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102636166	102636166	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr2:102636166G>A	ENST00000332549.3	+	5	809	c.580G>A	c.(580-582)Gta>Ata	p.V194I	IL1R2_ENST00000441002.1_Missense_Mutation_p.V194I|IL1R2_ENST00000393414.2_Missense_Mutation_p.V194I	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	194	Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	TCACTTACTCGTACACGATGT	0.423000													3	55					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370138	56370138	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:56370138C>T	ENST00000301295.6	+	3	1801	c.1379C>T	c.(1378-1380)gCc>gTc	p.A460V	NLRP4_ENST00000587891.1_Missense_Mutation_p.A385V|NLRP4_ENST00000346986.5_Missense_Mutation_p.A460V	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	460	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAGTTCTGTGCCGCCTTGTTC	0.512000													5	310					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148427438	148427438	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr5:148427438C>T	ENST00000515425.1	-	3	367	c.266G>A	c.(265-267)cGc>cAc	p.R89H	SH3TC2_ENST00000394358.2_5'UTR|SH3TC2_ENST00000512049.1_Missense_Mutation_p.R89H	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	89							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACAGCATGCGCACCTCCTG	0.527000													4	190					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70536394	70536394	+	Silent	SNP	C	C	T			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr8:70536394C>T	ENST00000260128.4	+	15	2529	c.1812C>T	c.(1810-1812)aaC>aaT	p.N604N	SULF1_ENST00000402687.4_Silent_p.N604N|SULF1_ENST00000419716.3_Silent_p.N604N|SULF1_ENST00000458141.2_Silent_p.N604N|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	604					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ATAGCAGCAACGCCGTGGGCC	0.512000													3	22					0	0	1	0	0
SGPP1	81537	broad.mit.edu	37	14	64153040	64153040	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:64153040A>G	ENST00000247225.6	-	3	1203	c.1109T>C	c.(1108-1110)cTc>cCc	p.L370P		NM_030791.2	NP_110418.1	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	370						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	10				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		CATCCCTATGAGGATCCGCAA	0.383000													3	224					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													3	48					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58949292	58949292	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:58949292G>A	ENST00000227451.3	+	2	396	c.292G>A	c.(292-294)Gac>Aac	p.D98N	DTX4_ENST00000532982.1_5'UTR	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	98	WWE 2.				Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				GTGGGAGAACGACAATGGCTC	0.617000													8	137					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48259051	48259051	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr7:48259051G>C	ENST00000435803.1	+	4	412	c.388G>C	c.(388-390)Gac>Cac	p.D130H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	130					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGGAATGATGGACAAGGCAAA	0.423000													10	199					0	0	1	0	0
PTPN23	25930	broad.mit.edu	37	3	47452810	47452810	+	Silent	SNP	G	G	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr3:47452810G>A	ENST00000265562.4	+	20	3599	c.3522G>A	c.(3520-3522)ttG>ttA	p.L1174L	PTPN23_ENST00000431726.1_Silent_p.L1048L	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	1174					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGCGGCAGTTGCAGCAGGAGC	0.647000													10	16					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278292	114278292	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr4:114278292C>A	ENST00000357077.4	+	38	8571	c.8518C>A	c.(8518-8520)Ccc>Acc	p.P2840T	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P2807T|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2807					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCAGATTGCCCCAGTGAAAG	0.393000													17	279					4.96729e-08	5.37004e-08	1	1	0
ZNF28	7576	broad.mit.edu	37	19	53303044	53303044	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:53303044T>A	ENST00000438150.2	-	2	2788	c.1895A>T	c.(1894-1896)cAt>cTt	p.H632L	ZNF28_ENST00000414252.2_Missense_Mutation_p.H632L|ZNF28_ENST00000360272.4_Missense_Mutation_p.H632L|ZNF28_ENST00000457749.2_Missense_Mutation_p.H685L			P17035	ZNF28_HUMAN	zinc finger protein 28	685					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		CTCTCCAGTATGAACTCTCTG	0.408000													5	396					0	0	1	0	0
ROM1	6094	broad.mit.edu	37	11	62381766	62381778	+	Frame_Shift_Del	DEL	TGATGGGGTCCCT	TGATGGGGTCCCT	-			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr11:62381766_62381778delTGATGGGGTCCCT	ENST00000278833.3	+	2	1168_1180	c.627_639delTGATGGGGTCCCT	c.(625-639)acfs	p.TDGVP209fs	ROM1_ENST00000534093.1_Start_Codon_Del	NM_000327.3	NP_000318.1	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	209					cell adhesion|visual perception	integral to plasma membrane				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	8						TATACCTGACTGATGGGGTCCCTTTCTCCTGTT	0.582													21	520	---	---	---	---					
RP11-478C19.2	0	broad.mit.edu	37	12	110868215	110868218	+	RNA	DEL	GTGT	GTGT	-	rs56304844		TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr12:110868215_110868218delGTGT	ENST00000550231.1	-	0	97																											CAgtgtgtgcgtgtgtgtgtgtgt	0.490													2	4	---	---	---	---					
DAOA-AS1	282706	broad.mit.edu	37	13	106148111	106148114	+	RNA	DEL	CTTC	CTTC	-			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr13:106148111_106148114delCTTC	ENST00000448407.1	-	0	100					NR_040247.1																						GGATCTTTCTcttccttccttcct	0.353													7	7	---	---	---	---					
TGM1	7051	broad.mit.edu	37	14	24727524	24727524	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr14:24727524delC	ENST00000206765.6	-	9	1492	c.1369delG	c.(1369-1371)tgfs	p.V458fs	TGM1_ENST00000544573.1_Frame_Shift_Del_p.V16fs	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	458					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GCATCCACCACCTGCCACCCA	0.602													13	40	---	---	---	---					
UHRF1	29128	broad.mit.edu	37	19	4933983	4933984	+	RNA	DEL	GC	GC	-	rs8108532		TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr19:4933983_4933984delGC	ENST00000592666.1	+	0	1361							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		gtgtgtgtgtgcgtgtgtgtgt	0.416													3	3	---	---	---	---					
MIR646HG	284757	broad.mit.edu	37	20	58889714	58889717	+	RNA	DEL	CCAT	CCAT	-			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr20:58889714_58889717delCCAT	ENST00000432910.1	+	0	332					NR_046099.1																						atccaccctcccatccatccatcc	0.539													3	4	---	---	---	---					
BCRP7	100133163	broad.mit.edu	37	22	18843613	18843613	+	RNA	DEL	G	G	-			TCGA-B0-5083-01A-02D-1421-08	TCGA-B0-5083-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2f90cb64-c4b8-45b1-a734-886b758871c9	6e87b1c0-278e-4d50-b05a-ee0fdf35c21d	g.chr22:18843613delG	ENST00000412938.1	+	0	2337																											AGGAGAGGCAGGGGCGGGGGT	0.622													3	6	---	---	---	---