Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ESPNP	284729	broad.mit.edu	37	1	17023403	17023403	+	RNA	SNP	G	G	A	rs10907267	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:17023403G>A	ENST00000492551.1	-	0	1544					NR_026567.1																						GGAACATCACGTTGAAAGACT	0.622000													5	71					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79365129	79365129	+	RNA	SNP	G	G	A	rs3819310		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:79365129G>A	ENST00000444841.1	-	0	129																											CAGGAGATCAGCATGAAGCAT	0.502000													9	153					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22236771	22236771	+	RNA	SNP	C	C	T	rs11623408	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:22236771C>T	ENST00000390428.3	+	0	43																											GTCTACATTTCAGGCCACATT	0.468000													22	389					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204378920	204378920	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:204378920T>A	ENST00000367188.4	-	1	1999	c.1620A>T	c.(1618-1620)gaA>gaT	p.E540D	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	540					regulation of translation			p.E540D(1)		breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CCCAGTCATCTTCCTCCCCAG	0.458000													14	23					0	0	1	0	0
RPS29	6235	broad.mit.edu	37	14	50053045	50053045	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:50053045T>C	ENST00000396020.3	-	1	49	c.20A>G	c.(19-21)tAc>tGc	p.Y7C	RPS29_ENST00000245458.6_Missense_Mutation_p.Y7C|RPS29_ENST00000557111.1_Intron	NM_001030001.1	NP_001025172.1	P62273	RS29_HUMAN	ribosomal protein S29	7					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome|zinc ion binding	p.Y7C(2)		endometrium(1)|kidney(1)|lung(1)|ovary(1)	4	all_epithelial(31;0.00214)|Breast(41;0.0124)					GTGGCTCCAGTACAGCTGCTG	0.522000													37	137					0	0	1	0	0
RRAS2	22800	broad.mit.edu	37	11	14316410	14316410	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:14316410T>A	ENST00000545643.1	-	3	528		c.e3-2		RRAS2_ENST00000256196.4_Splice_Site|RRAS2_ENST00000532814.1_Splice_Site|RRAS2_ENST00000414023.2_Splice_Site|RRAS2_ENST00000526063.1_Splice_Site|RRAS2_ENST00000529237.1_Splice_Site|RRAS2_ENST00000534746.1_Splice_Site|RRAS2_ENST00000537760.1_Splice_Site	NM_012250.5	NP_036382.2	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2							endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|endometrium(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	12				Epithelial(150;0.203)		TATCCAAAACTAAAGAAAAAA	0.398000													7	142					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189349247	189349247	+	Translation_Start_Site	SNP	A	A	T	rs28673064	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:189349247A>T	ENST00000264731.3	+	0	32				TP63_ENST00000382063.4_De_novo_Start_OutOfFrame	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63						anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACACAGGTATATGTGTATATT	0.368000										HNSCC(45;0.13)			3	24					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36755101	36755101	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:36755101C>T	ENST00000354618.5	+	5	1705	c.1481C>T	c.(1480-1482)tCt>tTt	p.S494F	THRAP3_ENST00000469141.2_Missense_Mutation_p.S494F	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	494					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.S494F(1)		breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAGGAGGAGTCTTTCCCAGAG	0.507000			T	USP6	aneurysmal bone cysts								62	138					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57913819	57913819	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:57913819T>C	ENST00000574161.1	+	4	451	c.332T>C	c.(331-333)tTg>tCg	p.L111S	MYZAP_ENST00000267853.5_Missense_Mutation_p.L111S|GCOM1_ENST00000380560.2_Intron|GCOM1_ENST00000380561.2_Intron|GCOM1_ENST00000572390.1_Missense_Mutation_p.L111S|MYZAP_ENST00000380565.4_Missense_Mutation_p.L111S|GCOM1_ENST00000380568.3_Missense_Mutation_p.L111S|GCOM1_ENST00000396180.1_Intron|POLR2M_ENST00000380563.2_Intron|GCOM1_ENST00000380569.2_Missense_Mutation_p.L111S|GCOM1_ENST00000587652.1_Missense_Mutation_p.L111S	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		111					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band		p.L111S(2)		endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						AGAGCCACTTTGGAAAAGGTG	0.383000													83	164					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65392741	65392741	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:65392741A>T	ENST00000355703.3	+	17	3558	c.3019A>T	c.(3019-3021)Acc>Tcc	p.T1007S		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1007						integral to membrane		p.T1007S(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CAGCGACCCCACCGTGCTCTG	0.647000													4	9					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61985847	61985847	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:61985847G>T	ENST00000409186.1	-	5	4490	c.2385C>A	c.(2383-2385)ttC>ttA	p.F795L	PCDH20_ENST00000409204.4_Missense_Mutation_p.F795L			Q8N6Y1	PCD20_HUMAN	protocadherin 20	768	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F795F(1)|p.F768F(1)		breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTCAATCCTGAAGGACTCAG	0.478000													15	310					1.67942e-08	1.86602e-08	1	1	0
INVS	27130	broad.mit.edu	37	9	103060386	103060386	+	Missense_Mutation	SNP	T	T	G	rs3813712	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:103060386T>G	ENST00000541287.1	+	17	3451	c.2897T>G	c.(2896-2898)aTa>aGa	p.I966R	INVS_ENST00000262456.2_Intron|INVS_ENST00000262457.2_Intron			Q9Y283	INVS_HUMAN	inversin	0					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				TTAGAACAGATATGGCCAGGG	0.418000													2	8					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38645403	38645403	+	RNA	SNP	T	T	C	rs72639552	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:38645403T>C	ENST00000494540.1	+	0	96					NR_003086.1																						TGGTTTTGATTACCGGGGCTA	0.617000													3	30					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409843	56409843	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:56409843C>T	ENST00000544374.1	-	1	104	c.76G>A	c.(76-78)Gac>Aac	p.D26N	OR5AP2_ENST00000302981.1_Missense_Mutation_p.D25N			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						TCTGGATTGTCGGAAAGTCCT	0.383000													17	111					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15068485	15068485	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:15068485C>A	ENST00000266397.2	-	6	1285	c.712G>T	c.(712-714)Gca>Tca	p.A238S	ERP27_ENST00000540097.1_Missense_Mutation_p.A137S	NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	238						endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						GAAACTTCTGCTGTGGGCAGT	0.408000													17	232					1.64113e-05	1.72751e-05	1	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121513577	121513577	+	Silent	SNP	C	C	T	rs140414935	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:121513577C>T	ENST00000393386.2	+	1	435	c.24C>T	c.(22-24)ctC>ctT	p.L8L	PTPRZ1_ENST00000449182.1_Silent_p.L8L	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	8					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGCGTTTCCTCGCTTGCATTC	0.597000													5	92					0	0	1	0	0
DCP2	167227	broad.mit.edu	37	5	112327832	112327832	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:112327832C>A	ENST00000389063.2	+	3	418	c.220C>A	c.(220-222)Ccg>Acg	p.P74T	DCP2_ENST00000543319.1_Intron|DCP2_ENST00000515408.1_Missense_Mutation_p.P74T	NM_152624.5	NP_689837.2	Q8IU60	DCP2_HUMAN	decapping mRNA 2	74					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		CAGTCATTGTCCGTTTTTGCT	0.338000													13	427					0.00074312	0.000773189	1	1	0
RNASE9	390443	broad.mit.edu	37	14	21025051	21025051	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:21025051G>T	ENST00000557068.1	-	4	1903	c.178C>A	c.(178-180)Cct>Act	p.P60T	RNASE9_ENST00000429244.2_Missense_Mutation_p.P60T|RNASE9_ENST00000557209.1_Missense_Mutation_p.P65T|RNASE9_ENST00000554964.1_Missense_Mutation_p.P60T|RNASE9_ENST00000555230.1_Missense_Mutation_p.P60T|RNASE9_ENST00000553706.1_Missense_Mutation_p.P65T|RNASE9_ENST00000553541.1_Missense_Mutation_p.P60T|RNASE9_ENST00000338904.3_Missense_Mutation_p.P60T|RNASE9_ENST00000556208.1_Missense_Mutation_p.P65T|RNASE9_ENST00000404716.3_Missense_Mutation_p.P65T			P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	60						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.P60T(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|ovary(2)|urinary_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TCTTTGGTAGGTGGTCTGGCG	0.358000													6	127					0.00116845	0.00120874	1	1	0
SMARCAD1	56916	broad.mit.edu	37	4	95158101	95158101	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:95158101A>T	ENST00000354268.4	+	5	610		c.e5-1		SMARCAD1_ENST00000457823.2_Splice_Site			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1						chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCGTTCTGTTAGTTGATTGAA	0.323000													9	152					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78340223	78340223	+	Missense_Mutation	SNP	G	G	A	rs145258663	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:78340223G>A	ENST00000255189.3	-	6	926	c.898C>T	c.(898-900)Ctc>Ttc	p.L300F	DMGDH_ENST00000380311.4_Missense_Mutation_p.L99F|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	300					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TCCTGTCGGAGATAATATGAT	0.448000													12	145					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7909785	7909785	+	Silent	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7909785T>A	ENST00000254854.4	+	4	1281	c.1131T>A	c.(1129-1131)gcT>gcA	p.A377A		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	377					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity	p.A377A(1)		skin(1)	1		Prostate(122;0.157)				CCGGAGCAGCTGTGGCCCGCC	0.677000													10	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065013	9065013	+	Missense_Mutation	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:9065013G>A	ENST00000397910.4	-	3	22636	c.22433C>T	c.(22432-22434)gCa>gTa	p.A7478V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7480	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGGTTACTGCCGTGTTTGA	0.483000													15	494					0	0	1	0	0
EXTL2	2135	broad.mit.edu	37	1	101339500	101339500	+	Nonstop_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:101339500A>T	ENST00000370114.3	-	5	2427	c.991T>A	c.(991-993)Taa>Aaa	p.*331K	EXTL2_ENST00000370113.3_Nonstop_Mutation_p.*331K|EXTL2_ENST00000535414.1_Nonstop_Mutation_p.*318K	NM_001033025.2|NM_001261440.1	NP_001028197.1|NP_001248369.1	Q9UBQ6	EXTL2_HUMAN	exostosin-like glycosyltransferase 2	0					N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	14		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		TTTTACTTTTATATTTTTCTT	0.303000													4	40					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7172406	7172406	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:7172406A>T	ENST00000406697.1	+	9	1148	c.520A>T	c.(520-522)Aat>Tat	p.N174Y	C1S_ENST00000402681.3_Missense_Mutation_p.N7Y|C1S_ENST00000360817.5_Missense_Mutation_p.N174Y|C1S_ENST00000328916.3_Missense_Mutation_p.N174Y			P09871	C1S_HUMAN	complement component 1, s subcomponent	174					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TCTGTTAGTTAATTGCAGTGG	0.423000													6	114					0	0	1	0	0
SMG6	23293	broad.mit.edu	37	17	2195926	2195926	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:2195926T>A	ENST00000544865.1	-	6	2676		c.e6-2		SMG6_ENST00000263073.5_Splice_Site			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AGGTACCAACTAGAACAGAAA	0.428000													9	200					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35836041	35836041	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:35836041G>T	ENST00000314607.6	+	7	1074	c.994G>T	c.(994-996)Gtt>Ttt	p.V332F	ZMYM4_ENST00000373297.2_Missense_Mutation_p.V332F|ZMYM4_ENST00000482131.1_3'UTR	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	332					multicellular organismal development		DNA binding|zinc ion binding	p.V332F(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCTTCCTTCAGTTCCAGCCAC	0.403000													20	38					1.00905e-13	1.13518e-13	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124968161	124968161	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:124968161C>A	ENST00000356219.3	-	4	547	c.392G>T	c.(391-393)gGa>gTa	p.G131V	NCOR2_ENST00000429285.2_Missense_Mutation_p.G131V|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000405201.1_Missense_Mutation_p.G131V|NCOR2_ENST00000404621.1_Missense_Mutation_p.G131V|NCOR2_ENST00000397355.1_Missense_Mutation_p.G131V	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	131					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.G131V(2)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTCTTCAGATCCCGCAGGCTG	0.647000													12	5					2.31682e-05	2.42458e-05	1	1	0
SMG7	9887	broad.mit.edu	37	1	183495729	183495729	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:183495729A>T	ENST00000367537.3	+	6	594		c.e6-1		SMG7_ENST00000508461.1_Splice_Site|SMG7_ENST00000507469.1_Splice_Site|SMG7_ENST00000456731.2_Splice_Site|SMG7_ENST00000507406.1_Splice_Site|SMG7_ENST00000515829.2_Splice_Site|SMG7_ENST00000347615.2_Splice_Site			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TTTTTCTTTTAGTTATTACAA	0.333000													6	77					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78196561	78196561	+	Missense_Mutation	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:78196561C>G	ENST00000361193.3	+	4	622	c.342C>G	c.(340-342)ttC>ttG	p.F114L	SLC26A11_ENST00000571602.1_3'UTR|SLC26A11_ENST00000546047.2_Missense_Mutation_p.F114L|SLC26A11_ENST00000572725.1_Missense_Mutation_p.F114L|SLC26A11_ENST00000411502.3_Missense_Mutation_p.F114L	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	114						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity	p.F114L(1)		central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGGTCTCCTTCTACACCTTCC	0.607000													176	156					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58520806	58520806	+	Silent	SNP	A	A	G	rs140431503	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:58520806A>G	ENST00000302819.5	-	2	319	c.28T>C	c.(28-30)Ttg>Ctg	p.L10L	ACOX2_ENST00000459701.2_Silent_p.L10L	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	10					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		GTATCCCCCAATGACACTCGG	0.567000													51	520					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85447027	85447027	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:85447027G>T	ENST00000369663.5	-	8	1537	c.1200C>A	c.(1198-1200)ttC>ttA	p.F400L	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	400					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.F400L(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GCCCCAGATGGAAGGCAGGAG	0.582000													10	96					1.76689e-08	1.95117e-08	1	1	0
PSG6	5675	broad.mit.edu	37	19	43414833	43414833	+	Missense_Mutation	SNP	T	T	C	rs147725300	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:43414833T>C	ENST00000187910.2	-	3	670	c.605A>G	c.(604-606)tAt>tGt	p.Y202C	PSG6_ENST00000402603.4_Missense_Mutation_p.Y202C|PSG6_ENST00000292125.2_Missense_Mutation_p.Y202C	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				ACCAAATAGATAGAGGGTCCT	0.507000													35	436					0	0	1	0	0
CASP14	23581	broad.mit.edu	37	19	15164766	15164766	+	Nonsense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:15164766G>T	ENST00000427043.3	+	4	708	c.400G>T	c.(400-402)Gga>Tga	p.G134*	CASP14_ENST00000221740.1_Nonsense_Mutation_p.G134*	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	134					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity	p.G134*(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						GGCCTGTCGAGGAGGTGGGGA	0.522000													64	141					2.94687e-45	3.53625e-45	1	1	0
SLC1A4	6509	broad.mit.edu	37	2	65237735	65237735	+	Missense_Mutation	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:65237735C>G	ENST00000234256.3	+	4	881	c.638C>G	c.(637-639)cCc>cGc	p.P213R	SLC1A4_ENST00000531327.1_5'UTR|SLC1A4_ENST00000493121.1_3'UTR	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	213					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	CTGCAGATCCCCATAGGCACT	0.448000													19	267					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30918079	30918079	+	Missense_Mutation	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:30918079G>A	ENST00000375712.3	+	8	2271	c.2104G>A	c.(2104-2106)Gca>Aca	p.A702T	KIF3B_ENST00000418717.2_Missense_Mutation_p.A328T	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	702	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding	p.A702T(1)		NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ACAGGTGGATGCATCATCATT	0.493000													70	68					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114448936	114448936	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:114448936C>A	ENST00000297405.5	-	1	392	c.148G>T	c.(148-150)Gtc>Ttc	p.V50F	CSMD3_ENST00000352409.3_Missense_Mutation_p.V50F|CSMD3_ENST00000455883.2_Missense_Mutation_p.V50F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	50						integral to membrane|plasma membrane		p.V50F(1)|p.V50L(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AATAAAAAGACGAGGTTCCAA	0.507000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			110	98					3.25107e-29	3.84995e-29	1	1	0
ZNF876P	642280	broad.mit.edu	37	4	206531	206531	+	RNA	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:206531C>G	ENST00000356347.3	+	0	133					NR_027481.1																						TTGGATGATTCGTAGCTAAGA	0.632000													8	28					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072236	17072236	+	Missense_Mutation	SNP	A	A	G	rs138335730	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:17072236A>G	ENST00000359963.3	-	1	1464	c.1205T>C	c.(1204-1206)cTa>cCa	p.L402P		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	402					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ATCTTGACATAGCTGGAAATA	0.567000													4	63					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102466737	102466737	+	Splice_Site	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:102466737G>A	ENST00000360184.4	+	18	4238		c.e18+1			NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1						cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding	p.?(1)		NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GCCTCGAAAGGTATATCATGA	0.403000													21	38					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234775512	234775512	+	RNA	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:234775512G>T	ENST00000438684.1	-	0	602					NR_024322.1																						CTTGTTCATAGGGATAGAGTA	0.388000													5	50					0.217242	0.219683	1	1	0
ZMYM4	9202	broad.mit.edu	37	1	35836039	35836039	+	Nonsense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:35836039C>A	ENST00000314607.6	+	7	1072	c.992C>A	c.(991-993)tCa>tAa	p.S331*	ZMYM4_ENST00000373297.2_Nonsense_Mutation_p.S331*|ZMYM4_ENST00000482131.1_3'UTR	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	331					multicellular organismal development		DNA binding|zinc ion binding	p.S331*(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGCTTCCTTCAGTTCCAGCC	0.398000													20	38					8.00594e-06	8.62916e-06	1	1	0
KRT4	3851	broad.mit.edu	37	12	53207418	53207418	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53207418T>C	ENST00000293774.4	-	1	917	c.647A>G	c.(646-648)aAg>aGg	p.K216R	KRT4_ENST00000458244.2_Missense_Mutation_p.K122R|KRT4_ENST00000551956.1_Missense_Mutation_p.K142R			B4DRS2	B4DRS2_HUMAN	keratin 4	142						keratin filament	structural molecule activity	p.K216R(1)		endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GTTGAGGAGCTTGATCTGTTC	0.562000													147	290					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3037187	3037187	+	Silent	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:3037187G>T	ENST00000398052.4	+	13	1687	c.1344G>T	c.(1342-1344)gtG>gtT	p.V448V	GRK4_ENST00000345167.6_Silent_p.V416V|GRK4_ENST00000504933.1_Silent_p.V448V|GRK4_ENST00000398051.4_Silent_p.V416V|GRK4_ENST00000509545.1_Intron	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	448	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGCACCCCGTGTTCAAGGACA	0.587000													99	454					1.54984e-59	1.87229e-59	1	1	0
GDI2	2665	broad.mit.edu	37	10	5838827	5838827	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:5838827T>A	ENST00000380191.4	-	3	444		c.e3-2		GDI2_ENST00000380181.3_Splice_Site|GDI2_ENST00000380132.4_Splice_Site	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2						protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						TTTGTATAACTAAAAGCAAGG	0.308000													4	33					0	0	1	0	0
DLGAP5	9787	broad.mit.edu	37	14	55625310	55625310	+	Silent	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:55625310T>C	ENST00000247191.2	-	14	2019	c.1803A>G	c.(1801-1803)ccA>ccG	p.P601P	DLGAP5_ENST00000395425.2_Silent_p.P601P	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	601					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding	p.P601P(1)		biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						CAACTTCCTTTGGTATCACAG	0.348000													16	76					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38658896	38658896	+	RNA	SNP	A	A	G	rs147623826	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:38658896A>G	ENST00000494540.1	+	0	740					NR_003086.1																						CTTTTTTGCAAATGCATTCAC	0.299000													4	78					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25261605	25261605	+	Silent	SNP	C	C	T	rs2228978	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:25261605C>T	ENST00000216962.4	+	11	1370	c.1260C>T	c.(1258-1260)ccC>ccT	p.P420P		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	420					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	CGCTGTTTCCCGGCGATGTGG	0.642000													7	106					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47280724	47280724	+	Translation_Start_Site	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:47280724C>A	ENST00000467728.1	+	0	1195				NR1H3_ENST00000395397.3_Intron|NR1H3_ENST00000481889.2_Intron|NR1H3_ENST00000405853.3_Intron|NR1H3_ENST00000441012.2_Intron|NR1H3_ENST00000407404.1_Intron|NR1H3_ENST00000405576.1_Intron|NR1H3_ENST00000529540.1_Intron			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3						apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						CTGGGTCCTTCCTGCAGGACA	0.517000													14	265					2.23348e-06	2.43653e-06	1	1	0
TBATA	219793	broad.mit.edu	37	10	72532300	72532300	+	Missense_Mutation	SNP	T	T	C	rs143899859	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:72532300T>C	ENST00000299290.1	-	10	1329	c.940A>G	c.(940-942)Ata>Gta	p.I314V		NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AAAGGTGATATCTTCGTTTTC	0.512000													25	365					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532807	92532807	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:92532807G>T	ENST00000298047.6	+	9	6645	c.6628G>T	c.(6628-6630)Gcc>Tcc	p.A2210S	FAT3_ENST00000525166.1_Missense_Mutation_p.A2060S|FAT3_ENST00000409404.2_Missense_Mutation_p.A2210S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2210	Cadherin 20.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGCATCAATGCCACCAGTCC	0.413000										TCGA Ovarian(4;0.039)			7	111					1.12685e-05	1.19314e-05	1	1	0
KRT76	51350	broad.mit.edu	37	12	53162498	53162498	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53162498C>T	ENST00000332411.2	-	9	1969	c.1916G>A	c.(1915-1917)tGa>tAa	p.*639*		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	0					cytoskeleton organization	keratin filament	structural molecule activity	p.*639*(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AACAGTAGATCACTTGGTGGA	0.517000													50	261					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78697880	78697880	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:78697880T>A	ENST00000334082.6	-	6	1970		c.e6-2		HOMER1_ENST00000282260.6_Intron|HOMER1_ENST00000508576.1_Intron|HOMER1_ENST00000535690.1_Splice_Site	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)						activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		ATTGCTGAACTAAAATAAAAC	0.408000													3	22					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133219900	133219900	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:133219900G>C	ENST00000320574.5	-	35	4504	c.4461C>G	c.(4459-4461)atC>atG	p.I1487M	POLE_ENST00000535270.1_Missense_Mutation_p.I1460M	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1487					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding	p.I1487M(2)		NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGTACAGGTAGATATGGCGGA	0.592000								DNA polymerases (catalytic subunits)					71	59					0	0	1	0	0
SLC25A33	84275	broad.mit.edu	37	1	9613721	9613721	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:9613721C>T	ENST00000302692.6	+	2	304	c.94C>T	c.(94-96)Cta>Tta	p.L32L		NM_032315.2	NP_115691.1	Q9BSK2	S2533_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	32					transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CACTTGTCCACTAGAAGTCAT	0.458000													87	583					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160273	132160273	+	Missense_Mutation	SNP	G	G	A	rs145695346	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:132160273G>A	ENST00000511190.1	-	6	2445	c.1976C>T	c.(1975-1977)aCg>aTg	p.T659M	USP26_ENST00000370832.1_Missense_Mutation_p.T659M|USP26_ENST00000406273.1_Missense_Mutation_p.T659M	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	659					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					TTCCAGATACGTCATTAAGTG	0.418000													6	127					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64827305	64827305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:64827305C>T	ENST00000332707.5	+	19	2903	c.2374C>T	c.(2374-2376)Cag>Tag	p.Q792*		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	792	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.Q792*(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		TTTAGAGAAGCAGATGTTGCG	0.468000													25	387					0	0	1	0	0
RSPO1	284654	broad.mit.edu	37	1	38079565	38079565	+	Splice_Site	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:38079565C>A	ENST00000356545.2	-	7	1224		c.e7-1		RSPO1_ENST00000401069.1_Splice_Site|RSPO1_ENST00000401070.1_Intron|RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000373059.1_Splice_Site|RSPO1_ENST00000401068.1_Splice_Site	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1						positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCACATTGCGCTGGCAGGAAG	0.607000													7	62					0.307466	0.309184	1	1	0
RAET1G	353091	broad.mit.edu	37	6	150240312	150240312	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:150240312T>A	ENST00000367360.2	-	3	565	c.498A>T	c.(496-498)agA>agT	p.R166S	RP11-244K5.1_ENST00000446954.1_RNA|RAET1G_ENST00000479265.1_Missense_Mutation_p.R166S|RP11-244K5.8_ENST00000606915.1_RNA|RP11-244K5.1_ENST00000605899.1_RNA	NM_001001788.2	NP_001001788.2	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G	166	MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding	p.R166S(1)		NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|urinary_tract(1)	13		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CTTTCATCTTTCTGGCTCCAG	0.473000													85	280					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51935825	51935825	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:51935825G>T	ENST00000371117.3	-	9	921	c.646C>A	c.(646-648)Cat>Aat	p.H216N	PKHD1_ENST00000340994.4_Missense_Mutation_p.H216N	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	216	IPT/TIG 2.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.H216N(2)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCTTCCACATGGCACTGCAGA	0.413000													36	166					4.07013e-28	4.78839e-28	1	1	0
SH3RF1	57630	broad.mit.edu	37	4	170077770	170077770	+	Missense_Mutation	SNP	C	C	G	rs144629121	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:170077770C>G	ENST00000284637.9	-	3	795	c.454G>C	c.(454-456)Gac>Cac	p.D152H	SH3RF1_ENST00000508685.1_5'UTR	NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	152	SH3 1.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		AATTTAAGGTCTCCAGGCTCT	0.373000													12	96					0	0	1	0	0
UTP18	51096	broad.mit.edu	37	17	49340732	49340732	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:49340732A>G	ENST00000225298.7	+	2	497	c.440A>G	c.(439-441)gAt>gGt	p.D147G		NM_016001.2	NP_057085.2	Q9Y5J1	UTP18_HUMAN	UTP18 small subunit (SSU) processome component homolog (yeast)	147					rRNA processing	nucleolus		p.D147G(1)		breast(2)|endometrium(3)|kidney(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			GATGAAGAAGATGAAGATGAG	0.358000													38	154					0	0	1	0	0
RAB28	9364	broad.mit.edu	37	4	13378197	13378197	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:13378197A>T	ENST00000288723.4	-	6	759	c.545T>A	c.(544-546)tTa>tAa	p.L182*	RAB28_ENST00000338176.4_Nonsense_Mutation_p.L182*|RAB28_ENST00000330852.5_Nonsense_Mutation_p.L182*	NM_004249.3	NP_004240.2	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family	182					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	8						TGCTTTGTTTAATTTGATCCC	0.303000													4	56					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100887766	100887766	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:100887766G>T	ENST00000358544.2	+	62	12052	c.11941G>T	c.(11941-11943)Gtg>Ttg	p.V3981L	VPS13B_ENST00000357162.2_Missense_Mutation_p.V3956L|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3981					protein transport			p.V3981L(1)|p.V3956L(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATGCCCTGTGGTGGCTGCAGA	0.468000													11	214					4.93089e-13	5.5128e-13	1	1	0
DPYD	1806	broad.mit.edu	37	1	98165090	98165090	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:98165090A>T	ENST00000370192.3	-	6	597	c.497T>A	c.(496-498)aTg>aAg	p.M166K	DPYD_ENST00000474241.1_5'UTR|DPYD_ENST00000423006.2_3'UTR	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	166			M -> V (in dbSNP:rs2297595).		'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGGGATACTCATTGCTTTGAA	0.388000													8	101					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793714	17793714	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:17793714T>C	ENST00000379472.3	+	2	1103	c.1073T>C	c.(1072-1074)aTc>aCc	p.I358T	KCNC1_ENST00000265969.6_Missense_Mutation_p.I358T	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	358						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.I358T(2)		breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGCGTGCTGATCTTCGCCACC	0.612000													26	61					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172227005	172227005	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:172227005A>T	ENST00000241261.2	-	4	541		c.e4+1		TNFSF10_ENST00000420541.2_Intron	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10						activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TGTTTCTCTTACTTGGAGAAG	0.358000													9	161					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670844	37670844	+	Missense_Mutation	SNP	T	T	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:37670844T>G	ENST00000422441.1	+	16	2116	c.1856T>G	c.(1855-1857)cTc>cGc	p.L619R	ITGA9_ENST00000264741.5_Intron			Q13797	ITA9_HUMAN	integrin, alpha 9	0					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		ACCTTAAAGCTCATACTCAGC	0.547000													5	22					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152711518	152711518	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:152711518A>T	ENST00000367255.5	-	53	8675	c.8074T>A	c.(8074-8076)Ttg>Atg	p.L2692M	SYNE1_ENST00000265368.4_Missense_Mutation_p.L2692M|SYNE1_ENST00000341594.5_Missense_Mutation_p.L2731M|SYNE1_ENST00000448038.1_Missense_Mutation_p.L2699M|SYNE1_ENST00000423061.1_Missense_Mutation_p.L2699M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2692					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.L2692M(2)|p.L2699M(1)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTACTTCTCAAGGCCTGTTCC	0.473000										HNSCC(10;0.0054)			11	123					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31549617	31549617	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31549617G>T	ENST00000429299.2	-	2	189	c.182C>A	c.(181-183)cCc>cAc	p.P61H	LTB_ENST00000483972.1_Intron|LTB_ENST00000446745.2_Intron	NM_002341.1	NP_002332.1	Q06643	TNFC_HUMAN	lymphotoxin beta (TNF superfamily, member 3)	61				DPGAQAQQGL -> GLSAPGSGRT (in Ref. 2; AAB37342).	cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9					Infliximab(DB00065)|Simvastatin(DB00641)	CTGTGCCCCGGGGTCGGCCGT	0.627000													12	84					8.60227e-14	9.73842e-14	1	1	0
MFAP3L	9848	broad.mit.edu	37	4	170912627	170912627	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:170912627C>A	ENST00000361618.3	-	3	1439	c.1132G>T	c.(1132-1134)Gta>Tta	p.V378L	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.V275L	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	378						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TTATCTGGTACCTCAACAGGT	0.502000													38	497					2.40579e-17	2.75823e-17	1	1	0
LRP2	4036	broad.mit.edu	37	2	170134463	170134463	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:170134463T>A	ENST00000263816.3	-	13	1851		c.e13-2		LRP2_ENST00000443831.1_Intron	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AATAAATAACTACAAAAGAAA	0.363000													4	34					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71682850	71682850	+	Silent	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:71682850A>G	ENST00000393524.2	-	17	4447	c.3714T>C	c.(3712-3714)ccT>ccC	p.P1238P	PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000356272.3_Silent_p.P1305P|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000568954.1_Silent_p.P1305P|PHLPP2_ENST00000567016.1_Silent_p.P1340P			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1305						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity	p.P1305P(1)		central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CATGGGGCTCAGGCTCGAGCC	0.582000													54	91					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44856401	44856401	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:44856401A>T	ENST00000326047.4	+	20	2532		c.e20-1		KIF15_ENST00000425755.1_Splice_Site	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TTTGTTTTTTAGTTTTGAAAA	0.358000													6	78					0	0	1	0	0
PRKAR2B	5577	broad.mit.edu	37	7	106793620	106793620	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:106793620A>T	ENST00000265717.4	+	8	1102		c.e8-1			NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						CTTTCTTTGTAGTTTTCTGAA	0.333000													4	44					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109772058	109772058	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:109772058A>G	ENST00000369923.4	+	4	322	c.311A>G	c.(310-312)aAa>aGa	p.K104R	SARS_ENST00000234677.2_Missense_Mutation_p.K104R			P49591	SYSC_HUMAN	seryl-tRNA synthetase	104					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity	p.K104R(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TCACAAATCAAAAAAGTCCGA	0.502000													78	639					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55223621	55223621	+	Missense_Mutation	SNP	G	G	A	rs139429793		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:55223621G>A	ENST00000275493.2	+	8	1165	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	EGFR_ENST00000455089.1_Missense_Mutation_p.E285K|EGFR_ENST00000420316.2_Missense_Mutation_p.E330K|EGFR_ENST00000454757.2_Missense_Mutation_p.E277K|EGFR_ENST00000344576.2_Missense_Mutation_p.E330K|EGFR_ENST00000442591.1_Missense_Mutation_p.E330K|EGFR_ENST00000342916.3_Missense_Mutation_p.E330K	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	330					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAGAAGTGCGAAGGGCCTTG	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			22	21					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197168567	197168567	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:197168567T>C	ENST00000367405.4	-	1	1105	c.1037A>G	c.(1036-1038)gAg>gGg	p.E346G	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E346G(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AGTTAACCCCTCATGAACATT	0.373000													48	154					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47738989	47738989	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:47738989C>T	ENST00000263773.5	-	17	3051	c.3039G>A	c.(3037-3039)atG>atA	p.M1013I		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	1013								p.M1013I(1)|p.M1013_A1014>IS(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						TGTTTGGAGCCATTTTCCTTC	0.333000													10	124					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14200007	14200007	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:14200007T>A	ENST00000285021.7	-	9	1590	c.1376A>T	c.(1375-1377)gAt>gTt	p.D459V	XPC_ENST00000449060.2_Missense_Mutation_p.D422V	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	459	Asp/Glu-rich (acidic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding	p.D459V(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGTTCGGAATCCTCATCAGA	0.577000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				10	30					0	0	1	0	0
CGA	1081	broad.mit.edu	37	6	87795978	87795978	+	Nonsense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:87795978G>T	ENST00000369582.2	-	3	363	c.263C>A	c.(262-264)tCa>tAa	p.S88*		NM_000735.3	NP_000726.1	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	88					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)	15		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		CCTGTTATATGATTTAGCTAC	0.453000													8	169					1.12685e-05	1.19314e-05	1	1	0
DST	667	broad.mit.edu	37	6	56373370	56373370	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:56373370C>A	ENST00000370754.5	-	75	19102	c.19103G>T	c.(19102-19104)gGa>gTa	p.G6368V	DST_ENST00000370769.4_Missense_Mutation_p.G6190V|DST_ENST00000340834.4_5'UTR|DST_ENST00000446842.2_Missense_Mutation_p.G5864V|DST_ENST00000421834.2_Missense_Mutation_p.G4102V|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.G3776V|DST_ENST00000370788.2_Missense_Mutation_p.G3993V|DST_ENST00000361203.3_Missense_Mutation_p.G6079V			Q03001	DYST_HUMAN	dystonin	6188					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGGATCAATTCCAGGATCTTC	0.378000													12	243					9.31168e-06	9.9768e-06	1	1	0
YTHDC2	64848	broad.mit.edu	37	5	112884236	112884236	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:112884236A>T	ENST00000161863.4	+	11	1708		c.e11-1		YTHDC2_ENST00000515883.1_Splice_Site	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2								ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TCCTTTTTTTAGTTGATTACA	0.348000													4	28					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155300229	155300229	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:155300229G>T	ENST00000368352.5	+	10	2727	c.2576G>T	c.(2575-2577)aGa>aTa	p.R859I	RUSC1_ENST00000368349.4_Missense_Mutation_p.R390I|RUSC1_ENST00000368347.4_Missense_Mutation_p.R449I|RUSC1_ENST00000368354.3_Missense_Mutation_p.R753I|RUSC1_ENST00000462780.1_3'UTR|RUSC1_ENST00000292254.4_Missense_Mutation_p.R390I	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	859	SH3.					cytoplasm|nucleolus	SH3/SH2 adaptor activity	p.R449I(1)|p.R390I(1)|p.R753I(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ACTGCTGCAAGACCTGACCAG	0.642000													34	514					3.09479e-21	3.57091e-21	1	1	0
GFOD2	81577	broad.mit.edu	37	16	67709603	67709603	+	Missense_Mutation	SNP	C	C	T	rs147012796		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:67709603C>T	ENST00000268797.7	-	3	958	c.613G>A	c.(613-615)Gtg>Atg	p.V205M	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	205						proteinaceous extracellular matrix	binding|oxidoreductase activity	p.V205M(1)		breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TTCTGCCTCACGAATGTCTTG	0.612000													5	78					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369428	56369428	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:56369428G>A	ENST00000301295.6	+	3	1091	c.669G>A	c.(667-669)ccG>ccA	p.P223P	NLRP4_ENST00000346986.5_Silent_p.P223P|NLRP4_ENST00000587891.1_Silent_p.P148P	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	223	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGTCTCAACCGGAGAGACTCT	0.557000													22	76					0	0	1	0	0
CHRNE	1145	broad.mit.edu	37	17	4804298	4804298	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:4804298G>A	ENST00000293780.4	-	7	799	c.789C>T	c.(787-789)ttC>ttT	p.F263F	C17orf107_ENST00000381365.3_3'UTR	NM_000080.3	NP_000071.1	Q04844	ACHE_HUMAN	cholinergic receptor, nicotinic, epsilon (muscle)	263					muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.F263F(1)		central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)	12						GCGCCGGCAGGAAGTAGGCGA	0.657000													9	39					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7172402	7172402	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:7172402A>T	ENST00000406697.1	+	9	1145		c.e9-1		C1S_ENST00000402681.3_Splice_Site|C1S_ENST00000360817.5_Splice_Site|C1S_ENST00000328916.3_Splice_Site			P09871	C1S_HUMAN	complement component 1, s subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTTCTCTGTTAGTTAATTGCA	0.418000													8	107					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450450	55450450	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:55450450C>A	ENST00000446217.1	-	6	2223	c.1821G>T	c.(1819-1821)caG>caT	p.Q607H	NLRP7_ENST00000448121.2_Missense_Mutation_p.Q579H|NLRP7_ENST00000592784.1_Missense_Mutation_p.Q579H|NLRP7_ENST00000590030.1_Missense_Mutation_p.Q579H|NLRP7_ENST00000588756.1_Missense_Mutation_p.Q579H|NLRP7_ENST00000340844.2_Missense_Mutation_p.Q579H|NLRP7_ENST00000328092.5_Missense_Mutation_p.Q579H			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	579							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GCTCCTCCTCCTGAGACTCAT	0.493000													75	503					2.35497e-27	2.75256e-27	1	1	0
ATG2B	55102	broad.mit.edu	37	14	96756058	96756058	+	Missense_Mutation	SNP	G	G	C	rs144991946	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:96756058G>C	ENST00000359933.4	-	41	6834	c.5941C>G	c.(5941-5943)Cgg>Ggg	p.R1981G		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1981										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGGGCTAACCGGTGATGAGGA	0.502000													29	346					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17029462	17029462	+	RNA	SNP	A	A	G	rs11260891	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:17029462A>G	ENST00000492551.1	-	0	903					NR_026567.1																						CTAGTGCTGGAAAGCCCTGGG	0.577000													7	19					0	0	1	0	0
PEX7	5191	broad.mit.edu	37	6	137167252	137167252	+	Silent	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:137167252C>A	ENST00000541292.1	+	5	545	c.459C>A	c.(457-459)ggC>ggA	p.G153G	PEX7_ENST00000318471.4_Silent_p.G153G			O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	153					ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding			lung(7)|prostate(1)	8	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		CCTTTAGAGGCCATGAAAGTA	0.363000													5	97					0.00307968	0.00316767	1	1	0
SMC3	9126	broad.mit.edu	37	10	112356197	112356197	+	Missense_Mutation	SNP	T	T	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:112356197T>G	ENST00000361804.4	+	19	2131	c.2005T>G	c.(2005-2007)Tat>Gat	p.Y669D		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	669					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity	p.Y669D(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TGGGGGTTATTATGACACAAG	0.383000													69	123					0	0	1	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967381	31967381	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:31967381A>T	ENST00000357886.4	-	9	1188	c.1035T>A	c.(1033-1035)taT>taA	p.Y345*	CDK5RAP1_ENST00000339269.5_Intron|CDK5RAP1_ENST00000452723.3_Nonsense_Mutation_p.Y241*|CDK5RAP1_ENST00000473997.1_5'UTR|CDK5RAP1_ENST00000346416.2_Nonsense_Mutation_p.Y331*|CDK5RAP1_ENST00000544843.1_Nonsense_Mutation_p.Y331*			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	345					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						GCTTGGTTTTATAGTTGGTGG	0.473000													7	145					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105635195	105635195	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:105635195A>T	ENST00000542731.1	+	5	621		c.e5-1		CDHR3_ENST00000541203.1_Intron|CDHR3_ENST00000317716.9_Splice_Site|CDHR3_ENST00000343407.5_Splice_Site|CDHR3_ENST00000470188.1_Intron|CDHR3_ENST00000478080.1_Splice_Site			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CTTGTTTTTTAGTATTTCCTG	0.438000													3	16					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107042546	107042546	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:107042546T>A	ENST00000409886.3	-	19	2693		c.e19-2		RGPD3_ENST00000304514.7_Splice_Site	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3						intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TAGTTGCAACTAAAAAAAAAA	0.338000													5	40					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545342	234545342	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:234545342C>T	ENST00000344644.5	+	1	243	c.174C>T	c.(172-174)gtC>gtT	p.V58V	UGT1A10_ENST00000373445.1_Silent_p.V58V|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1												p.V58V(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGTTGTAGTCATGCCAGAGG	0.517000													13	256					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48523269	48523269	+	Silent	SNP	G	G	A	rs148068614	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:48523269G>A	ENST00000422556.1	-	3	799	c.450C>T	c.(448-450)ctC>ctT	p.L150L	SPATA2_ENST00000543716.1_Silent_p.L13L|SPATA2_ENST00000289431.5_Silent_p.L150L	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	150					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			CGAGCTCTCTGAGCTTGTATG	0.502000													7	165					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42022431	42022431	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:42022431A>T	ENST00000264451.6	+	4	514		c.e4-1			NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTTTTTGTTTAGTTAAAGCAG	0.348000													5	56					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10795708	10795708	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:10795708G>A	ENST00000361367.2	+	22	3303	c.2877G>A	c.(2875-2877)aaG>aaA	p.K959K		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	959	Lys-rich.|Poly-Lys.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		agaagaaaaagaggagaagGT	0.368000													24	73					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136837	80136837	+	Silent	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:80136837C>A	ENST00000466387.1	+	11	1694	c.970C>A	c.(970-972)Cga>Aga	p.R324R	CTNNA2_ENST00000496558.1_Silent_p.R324R|CTNNA2_ENST00000541047.1_Silent_p.R324R|CTNNA2_ENST00000540488.1_Silent_p.R324R|CTNNA2_ENST00000402739.4_Silent_p.R324R|CTNNA2_ENST00000361291.4_Silent_p.R358R			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	324					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.R324R(2)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCCTGCACGCGAGACGACCG	0.647000													31	96					3.88204e-17	4.42257e-17	1	1	0
SLC7A10	56301	broad.mit.edu	37	19	33702235	33702235	+	Splice_Site	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:33702235C>G	ENST00000253188.3	-	7	1059		c.e7-1			NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity	p.?(1)		central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					CCCCGAAGGTCTGGGTGGGCA	0.617000													7	24					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103560981	103560981	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:103560981C>T	ENST00000226578.4	-	14	2002	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K	MANBA_ENST00000505239.1_Missense_Mutation_p.E578K	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	635					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CGGTAGAATTCAGTTTCTGTT	0.468000													5	63					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40866017	40866017	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:40866017G>C	ENST00000315616.7	+	3	1233	c.1195G>C	c.(1195-1197)Ggc>Cgc	p.G399R	RPUSD2_ENST00000559271.1_Missense_Mutation_p.G338R	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	399					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding	p.G399R(1)		kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TCCTTCTCGAGGCCGGGGCGG	0.572000													71	202					0	0	1	0	0
MRRF	92399	broad.mit.edu	37	9	125033141	125033141	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:125033141A>T	ENST00000344641.3	+	2	283		c.e2-1		MRRF_ENST00000297908.3_Splice_Site|MRRF_ENST00000373723.4_Splice_Site|MRRF_ENST00000546115.1_Splice_Site|MRRF_ENST00000373727.1_Splice_Site|MRRF_ENST00000373729.1_Intron|MRRF_ENST00000373728.1_Splice_Site|MRRF_ENST00000373730.3_Splice_Site	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor						ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						TATTCTTTTTAGTGGATGTTT	0.393000													7	154					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223940635	223940635	+	Missense_Mutation	SNP	C	C	T	rs145466296	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:223940635C>T	ENST00000295006.5	+	9	1421	c.1112C>T	c.(1111-1113)gCg>gTg	p.A371V	CAPN2_ENST00000433674.2_Missense_Mutation_p.A293V	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	371	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGCTCCACCGCGGGAGGTTGC	0.567000													9	163					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39051932	39051932	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:39051932G>A	ENST00000355481.4	+	89	12578	c.12447G>A	c.(12445-12447)ccG>ccA	p.P4149P	RYR1_ENST00000359596.3_Silent_p.P4154P|RYR1_ENST00000360985.3_Silent_p.P4149P	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4154					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.P4154P(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCATGTGCCGCATGACCCTC	0.627000													202	455					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7636022	7636022	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:7636022C>T	ENST00000340080.4	+	11	2752	c.2331C>T	c.(2329-2331)ggC>ggT	p.G777G	MIOS_ENST00000405785.1_Silent_p.G777G	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	777								p.G777G(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GTTGTCCTGGCTGTCGAAAAC	0.433000													57	172					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724757	138724757	+	Silent	SNP	C	C	G	rs11924188	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:138724757C>G	ENST00000383163.2	-	1	353	c.354G>C	c.(352-354)tcG>tcC	p.S118S	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	118										endometrium(3)|kidney(1)|lung(7)	11						GCCCAGCAGACGAGTCGTCCT	0.617000													14	90					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708271	36708271	+	Missense_Mutation	SNP	A	A	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:36708271A>C	ENST00000264659.7	-	14	2802	c.2578T>G	c.(2578-2580)Ttc>Gtc	p.F860V	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Missense_Mutation_p.F894V	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	732	Pro-rich.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding	p.F860V(1)		endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						GGCATTTCGAAGTCCACGCTC	0.617000													23	35					0	0	1	0	0
SAG	6295	broad.mit.edu	37	2	234255451	234255451	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:234255451A>T	ENST00000409110.1	+	16	1342		c.e16-1			NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)						rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		GTTTTATTTTAGTTATCAGGA	0.388000													7	44					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103132475	103132475	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:103132475T>A	ENST00000428762.1	-	58	9529		c.e58-2		CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Splice_Site|RELN_ENST00000424685.2_Splice_Site	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCACAATCTAAAACAAACA	0.333000													4	30					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39553696	39553696	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:39553696G>A	ENST00000251645.2	-	1	148	c.96C>T	c.(94-96)ccC>ccT	p.P32P		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	32	Head.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				TGCAGGCCCCGGGCAGGGTGC	0.637000													11	267					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103452870	103452870	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:103452870C>A	ENST00000361246.2	-	6	932	c.644G>T	c.(643-645)cGc>cTc	p.R215L		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	215	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GTCAGCCAGGCGGATATGACC	0.378000													19	288					0.667858	0.667858	1	1	0
EPB41L5	57669	broad.mit.edu	37	2	120900686	120900686	+	Silent	SNP	T	T	C	rs61730480	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:120900686T>C	ENST00000263713.5	+	19	1921	c.1707T>C	c.(1705-1707)gcT>gcC	p.A569A	EPB41L5_ENST00000452780.1_Silent_p.A569A|EPB41L5_ENST00000443902.2_Silent_p.A569A	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	569						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TTTTGAAGGCTCAAGTAGAAG	0.428000													15	442					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117681127	117681127	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:117681127C>T	ENST00000317775.6	-	19	3622	c.2937G>A	c.(2935-2937)gtG>gtA	p.V979V	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.V1013V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	979					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.V979V(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GAGCTTCGGCCACAAAGGTGA	0.517000													52	473					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48977501	48977501	+	Missense_Mutation	SNP	G	G	A	rs1804728		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:48977501G>A	ENST00000427476.1	+	7	910	c.610G>A	c.(610-612)Gtc>Atc	p.V204I	CYTH2_ENST00000452733.2_Missense_Mutation_p.V204I	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	204					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding	p.V204I(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						CAATCCCAATGTCCGGGACAA	0.632000													57	139					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160062372	160062372	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:160062372C>A	ENST00000368086.1	-	5	1642	c.1426G>T	c.(1426-1428)Gcc>Tcc	p.A476S	IGSF8_ENST00000314485.7_Missense_Mutation_p.A476S			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	476	Ig-like C2-type 4.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CAGCTGGCGGCCAGCCGCAGT	0.687000													5	75					0.014758	0.0150081	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96106258	96106258	+	Silent	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:96106258G>T	ENST00000453304.1	-	13	2574	c.2226C>A	c.(2224-2226)cgC>cgA	p.R742R		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	742					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAATTGACAGGCGCAGGTTGT	0.458000													36	180					1.43246e-33	1.70757e-33	1	1	0
DPY19L1	23333	broad.mit.edu	37	7	34981390	34981390	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:34981390A>G	ENST00000310974.4	-	18	1601	c.1457T>C	c.(1456-1458)aTc>aCc	p.I486T		NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	486						integral to membrane		p.I486T(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						TCTTGAGCAGATCAGTGATGC	0.343000													13	42					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554161	140554161	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:140554161C>T	ENST00000231137.3	+	1	1919	c.1745C>T	c.(1744-1746)cCg>cTg	p.P582L		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		582	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P582L(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCCGAGCCGGGCTACCTG	0.697000													7	22					0	0	1	0	0
ALG3	10195	broad.mit.edu	37	3	183960405	183960405	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:183960405C>T	ENST00000455059.1	-	9	1548	c.1094G>A	c.(1093-1095)aGc>aAc	p.S365N	EIF2B5_ENST00000444495.1_Intron|ALG3_ENST00000445626.2_Missense_Mutation_p.S357N|ALG3_ENST00000397676.3_Missense_Mutation_p.S405N|ALG3_ENST00000418734.2_Missense_Mutation_p.S349N			Q92685	ALG3_HUMAN	ALG3, alpha-1,3- mannosyltransferase	405					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCAGCAGAGCTGCAGGATGT	0.572000													5	99					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31484489	31484489	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:31484489G>A	ENST00000322054.5	+	5	1275	c.990G>A	c.(988-990)gaG>gaA	p.E330E	EHD3_ENST00000541626.1_Intron	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	330					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding	p.E330E(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					AGAAGAAGGAGCTGGTCAACA	0.572000													203	86					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47738988	47738988	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:47738988C>A	ENST00000263773.5	-	17	3052	c.3040G>T	c.(3040-3042)Gct>Tct	p.A1014S		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	1014								p.M1013_A1014>IS(1)|p.A1014S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						GTGTTTGGAGCCATTTTCCTT	0.333000													10	121					1.58986e-06	1.74497e-06	1	1	0
ANK3	288	broad.mit.edu	37	10	61840378	61840378	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:61840378T>A	ENST00000280772.1	-	36	4542		c.e36-2		ANK3_ENST00000503366.1_Splice_Site|ANK3_ENST00000373827.2_Splice_Site|ANK3_ENST00000355288.2_Splice_Site	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTCAATCTGAAAAGGAAA	0.378000													4	56					0	0	1	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44751187	44751187	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:44751187A>T	ENST00000260327.4	+	2	539		c.e2-1		CTDSPL2_ENST00000558966.1_Splice_Site|CTDSPL2_ENST00000396780.1_Splice_Site	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2								phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		tttCTCTTTTAGTTTTACATG	0.343000													5	19					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507132	64507132	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:64507132G>C	ENST00000377494.1	-	6	1594	c.672C>G	c.(670-672)atC>atG	p.I224M	RASGRP2_ENST00000354024.3_Missense_Mutation_p.I224M|RASGRP2_ENST00000394432.3_Missense_Mutation_p.I224M|RASGRP2_ENST00000377497.3_Missense_Mutation_p.I224M			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	224	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity	p.I286M(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAAAGTGTGTGATGACCAGGG	0.637000													22	61					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173523955	173523955	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:173523955T>A	ENST00000367714.3	-	11	1638		c.e11-2		SLC9C2_ENST00000536496.1_Splice_Site|SLC9C2_ENST00000466087.1_Intron	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GAGTATAAACTAAAAACAAAG	0.294000													6	121					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67559027	67559027	+	Silent	SNP	C	C	T	rs139606703		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:67559027C>T	ENST00000371007.2	-	8	973	c.864G>A	c.(862-864)gcG>gcA	p.A288A	C1orf141_ENST00000544837.1_Silent_p.A288A|C1orf141_ENST00000371006.1_Silent_p.A288A	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	288										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TTGTGTGGCCCGCTTTAAAAG	0.323000													6	51					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33091085	33091085	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:33091085G>A	ENST00000334528.9	-	15	3380	c.3381C>T	c.(3379-3381)taC>taT	p.Y1127Y	FMN1_ENST00000561249.1_Silent_p.Y1252Y|FMN1_ENST00000559047.1_Silent_p.Y1350Y	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	1350	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCATAAACACGTAGCTGGGTG	0.403000													5	101					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63030443	63030443	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:63030443A>G	ENST00000561311.1	+	29	3828	c.3598A>G	c.(3598-3600)Aac>Gac	p.N1200D	TLN2_ENST00000559908.1_3'UTR|TLN2_ENST00000306829.6_Missense_Mutation_p.N1200D			Q9Y4G6	TLN2_HUMAN	talin 2	1200					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton	p.N1200D(1)		NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTCCTTGAATAACTGCGTAAA	0.502000													237	171					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186086589	186086589	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:186086589A>T	ENST00000271588.4	+	77	11912		c.e77-1		HMCN1_ENST00000367492.2_Splice_Site	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1						response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTGTTGTTTTAGTTCCACCTT	0.403000													6	70					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	33836390	33836390	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:33836390A>T	ENST00000548645.1	+	3	340		c.e3-1		NPAS3_ENST00000357798.5_Splice_Site|NPAS3_ENST00000547068.1_Intron|NPAS3_ENST00000346562.2_Intron|NPAS3_ENST00000551008.1_Splice_Site|NPAS3_ENST00000551492.1_Intron|NPAS3_ENST00000341321.4_Splice_Site|NPAS3_ENST00000356141.4_Splice_Site			Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TTTTCTTTTAAGTTATAGGTG	0.368000													4	31					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43481848	43481848	+	Missense_Mutation	SNP	C	C	A	rs149944561	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:43481848C>A	ENST00000532038.1	-	5	911	c.776G>T	c.(775-777)gGt>gTt	p.G259V	ARHGAP27_ENST00000455881.1_Missense_Mutation_p.G118V|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.G432V|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.G91V|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.G459V|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.G459V|ARHGAP27_ENST00000376922.2_Missense_Mutation_p.G118V			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	459	WW 1.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					TGGGGTGTCACCATCCTGGCT	0.607000													4	37					0.014758	0.0150081	1	1	0
ZADH2	284273	broad.mit.edu	37	18	72914297	72914297	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr18:72914297T>A	ENST00000322342.3	-	2	499		c.e2-2		ZADH2_ENST00000537114.2_Splice_Site	NM_175907.4	NP_787103.1	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain containing 2							peroxisome	oxidoreductase activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(8)|skin(1)	15		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		CCAACAAATCTAAAAGAAAAC	0.428000													7	151					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17023403	17023403	+	RNA	SNP	G	G	A	rs10907267	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:17023403G>A	ENST00000492551.1	-	0	1544					NR_026567.1																						GGAACATCACGTTGAAAGACT	0.622000													5	71					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79365129	79365129	+	RNA	SNP	G	G	A	rs3819310		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:79365129G>A	ENST00000444841.1	-	0	129																											CAGGAGATCAGCATGAAGCAT	0.502000													9	153					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22236771	22236771	+	RNA	SNP	C	C	T	rs11623408	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:22236771C>T	ENST00000390428.3	+	0	43																											GTCTACATTTCAGGCCACATT	0.468000													22	389					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204378920	204378920	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:204378920T>A	ENST00000367188.4	-	1	1999	c.1620A>T	c.(1618-1620)gaA>gaT	p.E540D	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	540					regulation of translation			p.E540D(1)		breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CCCAGTCATCTTCCTCCCCAG	0.458000													14	23					0	0	1	0	0
RPS29	6235	broad.mit.edu	37	14	50053045	50053045	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:50053045T>C	ENST00000396020.3	-	1	49	c.20A>G	c.(19-21)tAc>tGc	p.Y7C	RPS29_ENST00000557111.1_Intron|RPS29_ENST00000245458.6_Missense_Mutation_p.Y7C	NM_001030001.1	NP_001025172.1	P62273	RS29_HUMAN	ribosomal protein S29	7					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome|zinc ion binding	p.Y7C(2)		endometrium(1)|kidney(1)|lung(1)|ovary(1)	4	all_epithelial(31;0.00214)|Breast(41;0.0124)					GTGGCTCCAGTACAGCTGCTG	0.522000													37	137					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189349247	189349247	+	Translation_Start_Site	SNP	A	A	T	rs28673064	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:189349247A>T	ENST00000264731.3	+	0	32				TP63_ENST00000382063.4_De_novo_Start_OutOfFrame	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63						anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACACAGGTATATGTGTATATT	0.368000										HNSCC(45;0.13)			3	24					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36755101	36755101	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:36755101C>T	ENST00000354618.5	+	5	1705	c.1481C>T	c.(1480-1482)tCt>tTt	p.S494F	THRAP3_ENST00000469141.2_Missense_Mutation_p.S494F	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	494					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.S494F(1)		breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAGGAGGAGTCTTTCCCAGAG	0.507000			T	USP6	aneurysmal bone cysts								62	138					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57913819	57913819	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:57913819T>C	ENST00000574161.1	+	4	451	c.332T>C	c.(331-333)tTg>tCg	p.L111S	GCOM1_ENST00000380569.2_Missense_Mutation_p.L111S|GCOM1_ENST00000380568.3_Missense_Mutation_p.L111S|GCOM1_ENST00000587652.1_Missense_Mutation_p.L111S|MYZAP_ENST00000267853.5_Missense_Mutation_p.L111S|MYZAP_ENST00000380565.4_Missense_Mutation_p.L111S|GCOM1_ENST00000380561.2_Intron|POLR2M_ENST00000380563.2_Intron|GCOM1_ENST00000380560.2_Intron|GCOM1_ENST00000572390.1_Missense_Mutation_p.L111S|GCOM1_ENST00000396180.1_Intron	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		111					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band		p.L111S(2)		endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						AGAGCCACTTTGGAAAAGGTG	0.383000													83	164					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65392741	65392741	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:65392741A>T	ENST00000355703.3	+	17	3558	c.3019A>T	c.(3019-3021)Acc>Tcc	p.T1007S		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1007						integral to membrane		p.T1007S(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CAGCGACCCCACCGTGCTCTG	0.647000													4	9					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61985847	61985847	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr13:61985847G>T	ENST00000409186.1	-	5	4490	c.2385C>A	c.(2383-2385)ttC>ttA	p.F795L	PCDH20_ENST00000409204.4_Missense_Mutation_p.F795L			Q8N6Y1	PCD20_HUMAN	protocadherin 20	768	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F795F(1)|p.F768F(1)		breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTCAATCCTGAAGGACTCAG	0.478000													15	310					1.67942e-08	1.91018e-08	1	1	0
INVS	27130	broad.mit.edu	37	9	103060386	103060386	+	Missense_Mutation	SNP	T	T	G	rs3813712	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr9:103060386T>G	ENST00000541287.1	+	17	3451	c.2897T>G	c.(2896-2898)aTa>aGa	p.I966R	INVS_ENST00000262457.2_Intron|INVS_ENST00000262456.2_Intron			Q9Y283	INVS_HUMAN	inversin	0					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				TTAGAACAGATATGGCCAGGG	0.418000													2	8					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409843	56409843	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:56409843C>T	ENST00000544374.1	-	1	104	c.76G>A	c.(76-78)Gac>Aac	p.D26N	OR5AP2_ENST00000302981.1_Missense_Mutation_p.D25N			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						TCTGGATTGTCGGAAAGTCCT	0.383000													17	111					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15068485	15068485	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:15068485C>A	ENST00000266397.2	-	6	1285	c.712G>T	c.(712-714)Gca>Tca	p.A238S	ERP27_ENST00000540097.1_Missense_Mutation_p.A137S	NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	238						endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						GAAACTTCTGCTGTGGGCAGT	0.408000													17	232					1.64113e-05	1.7592e-05	1	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121513577	121513577	+	Silent	SNP	C	C	T	rs140414935	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:121513577C>T	ENST00000393386.2	+	1	435	c.24C>T	c.(22-24)ctC>ctT	p.L8L	PTPRZ1_ENST00000449182.1_Silent_p.L8L	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	8					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGCGTTTCCTCGCTTGCATTC	0.597000													5	92					0	0	1	0	0
DCP2	167227	broad.mit.edu	37	5	112327832	112327832	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:112327832C>A	ENST00000389063.2	+	3	418	c.220C>A	c.(220-222)Ccg>Acg	p.P74T	DCP2_ENST00000543319.1_Intron|DCP2_ENST00000515408.1_Missense_Mutation_p.P74T	NM_152624.5	NP_689837.2	Q8IU60	DCP2_HUMAN	decapping mRNA 2	74					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		CAGTCATTGTCCGTTTTTGCT	0.338000													13	427					0.00074312	0.000785283	1	1	0
RNASE9	390443	broad.mit.edu	37	14	21025051	21025051	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:21025051G>T	ENST00000557068.1	-	4	1903	c.178C>A	c.(178-180)Cct>Act	p.P60T	RNASE9_ENST00000557209.1_Missense_Mutation_p.P65T|RNASE9_ENST00000554964.1_Missense_Mutation_p.P60T|RNASE9_ENST00000429244.2_Missense_Mutation_p.P60T|RNASE9_ENST00000556208.1_Missense_Mutation_p.P65T|RNASE9_ENST00000404716.3_Missense_Mutation_p.P65T|RNASE9_ENST00000555230.1_Missense_Mutation_p.P60T|RNASE9_ENST00000338904.3_Missense_Mutation_p.P60T|RNASE9_ENST00000553706.1_Missense_Mutation_p.P65T|RNASE9_ENST00000553541.1_Missense_Mutation_p.P60T			P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	60						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.P60T(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|ovary(2)|urinary_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TCTTTGGTAGGTGGTCTGGCG	0.358000													6	127					0.00116845	0.00122604	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78340223	78340223	+	Missense_Mutation	SNP	G	G	A	rs145258663	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:78340223G>A	ENST00000255189.3	-	6	926	c.898C>T	c.(898-900)Ctc>Ttc	p.L300F	DMGDH_ENST00000380311.4_Missense_Mutation_p.L99F|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	300					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TCCTGTCGGAGATAATATGAT	0.448000													12	145					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7909785	7909785	+	Silent	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:7909785T>A	ENST00000254854.4	+	4	1281	c.1131T>A	c.(1129-1131)gcT>gcA	p.A377A		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	377					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity	p.A377A(1)		skin(1)	1		Prostate(122;0.157)				CCGGAGCAGCTGTGGCCCGCC	0.677000													10	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065013	9065013	+	Missense_Mutation	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:9065013G>A	ENST00000397910.4	-	3	22636	c.22433C>T	c.(22432-22434)gCa>gTa	p.A7478V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7480	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGGTTACTGCCGTGTTTGA	0.483000													15	494					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35836041	35836041	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:35836041G>T	ENST00000314607.6	+	7	1074	c.994G>T	c.(994-996)Gtt>Ttt	p.V332F	ZMYM4_ENST00000373297.2_Missense_Mutation_p.V332F|ZMYM4_ENST00000482131.1_3'UTR	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	332					multicellular organismal development		DNA binding|zinc ion binding	p.V332F(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCTTCCTTCAGTTCCAGCCAC	0.403000													20	38					1.00905e-13	1.16549e-13	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124968161	124968161	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:124968161C>A	ENST00000356219.3	-	4	547	c.392G>T	c.(391-393)gGa>gTa	p.G131V	NCOR2_ENST00000405201.1_Missense_Mutation_p.G131V|NCOR2_ENST00000404621.1_Missense_Mutation_p.G131V|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000397355.1_Missense_Mutation_p.G131V|NCOR2_ENST00000429285.2_Missense_Mutation_p.G131V	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	131					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.G131V(2)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTCTTCAGATCCCGCAGGCTG	0.647000													12	5					2.31682e-05	2.46576e-05	1	1	0
SLC26A11	284129	broad.mit.edu	37	17	78196561	78196561	+	Missense_Mutation	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:78196561C>G	ENST00000361193.3	+	4	622	c.342C>G	c.(340-342)ttC>ttG	p.F114L	SLC26A11_ENST00000546047.2_Missense_Mutation_p.F114L|SLC26A11_ENST00000572725.1_Missense_Mutation_p.F114L|SLC26A11_ENST00000571602.1_3'UTR|SLC26A11_ENST00000411502.3_Missense_Mutation_p.F114L	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	114						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity	p.F114L(1)		central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGGTCTCCTTCTACACCTTCC	0.607000													176	156					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58520806	58520806	+	Silent	SNP	A	A	G	rs140431503	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:58520806A>G	ENST00000302819.5	-	2	319	c.28T>C	c.(28-30)Ttg>Ctg	p.L10L	ACOX2_ENST00000459701.2_Silent_p.L10L	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	10					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		GTATCCCCCAATGACACTCGG	0.567000													51	520					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85447027	85447027	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:85447027G>T	ENST00000369663.5	-	8	1537	c.1200C>A	c.(1198-1200)ttC>ttA	p.F400L	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	400					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.F400L(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GCCCCAGATGGAAGGCAGGAG	0.582000													10	96					1.76689e-08	1.99445e-08	1	1	0
PSG6	5675	broad.mit.edu	37	19	43414833	43414833	+	Missense_Mutation	SNP	T	T	C	rs147725300	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:43414833T>C	ENST00000187910.2	-	3	670	c.605A>G	c.(604-606)tAt>tGt	p.Y202C	PSG6_ENST00000402603.4_Missense_Mutation_p.Y202C|PSG6_ENST00000292125.2_Missense_Mutation_p.Y202C	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				ACCAAATAGATAGAGGGTCCT	0.507000													35	436					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65237735	65237735	+	Missense_Mutation	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:65237735C>G	ENST00000234256.3	+	4	881	c.638C>G	c.(637-639)cCc>cGc	p.P213R	SLC1A4_ENST00000493121.1_3'UTR|SLC1A4_ENST00000531327.1_5'UTR	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	213					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	CTGCAGATCCCCATAGGCACT	0.448000													19	267					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30918079	30918079	+	Missense_Mutation	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr20:30918079G>A	ENST00000375712.3	+	8	2271	c.2104G>A	c.(2104-2106)Gca>Aca	p.A702T	KIF3B_ENST00000418717.2_Missense_Mutation_p.A328T	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	702	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding	p.A702T(1)		NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ACAGGTGGATGCATCATCATT	0.493000													70	68					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114448936	114448936	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr8:114448936C>A	ENST00000297405.5	-	1	392	c.148G>T	c.(148-150)Gtc>Ttc	p.V50F	CSMD3_ENST00000455883.2_Missense_Mutation_p.V50F|CSMD3_ENST00000352409.3_Missense_Mutation_p.V50F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	50						integral to membrane|plasma membrane		p.V50F(1)|p.V50L(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AATAAAAAGACGAGGTTCCAA	0.507000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			110	98					3.25107e-29	4.00339e-29	1	1	0
ZNF876P	642280	broad.mit.edu	37	4	206531	206531	+	RNA	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:206531C>G	ENST00000356347.3	+	0	133					NR_027481.1																						TTGGATGATTCGTAGCTAAGA	0.632000													8	28					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102466737	102466737	+	Splice_Site	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:102466737G>A	ENST00000360184.4	+	18	4238		c.e18+1			NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1						cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding	p.?(1)		NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GCCTCGAAAGGTATATCATGA	0.403000													21	38					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234775512	234775512	+	RNA	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:234775512G>T	ENST00000438684.1	-	0	602					NR_024322.1																						CTTGTTCATAGGGATAGAGTA	0.388000													5	50					0.217242	0.220198	1	1	0
ZMYM4	9202	broad.mit.edu	37	1	35836039	35836039	+	Nonsense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:35836039C>A	ENST00000314607.6	+	7	1072	c.992C>A	c.(991-993)tCa>tAa	p.S331*	ZMYM4_ENST00000373297.2_Nonsense_Mutation_p.S331*|ZMYM4_ENST00000482131.1_3'UTR	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	331					multicellular organismal development		DNA binding|zinc ion binding	p.S331*(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGCTTCCTTCAGTTCCAGCC	0.398000													20	38					8.00594e-06	8.83619e-06	1	1	0
KRT4	3851	broad.mit.edu	37	12	53207418	53207418	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:53207418T>C	ENST00000551956.1	-	1	917	c.425A>G	c.(424-426)aAg>aGg	p.K142R	KRT4_ENST00000293774.4_Missense_Mutation_p.K216R|KRT4_ENST00000458244.2_Missense_Mutation_p.K122R			B4DRS2	B4DRS2_HUMAN	keratin 4	142						keratin filament	structural molecule activity	p.K216R(1)		endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GTTGAGGAGCTTGATCTGTTC	0.562000													147	290					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3037187	3037187	+	Silent	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:3037187G>T	ENST00000398052.4	+	13	1687	c.1344G>T	c.(1342-1344)gtG>gtT	p.V448V	GRK4_ENST00000504933.1_Silent_p.V448V|GRK4_ENST00000509545.1_Intron|GRK4_ENST00000398051.4_Silent_p.V416V|GRK4_ENST00000345167.6_Silent_p.V416V	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	448	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGCACCCCGTGTTCAAGGACA	0.587000													99	454					1.54984e-59	1.95701e-59	1	1	0
MIOS	54468	broad.mit.edu	37	7	7636022	7636022	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:7636022C>T	ENST00000340080.4	+	11	2752	c.2331C>T	c.(2329-2331)ggC>ggT	p.G777G	MIOS_ENST00000405785.1_Silent_p.G777G	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	777								p.G777G(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GTTGTCCTGGCTGTCGAAAAC	0.433000													57	172					0	0	1	0	0
DLGAP5	9787	broad.mit.edu	37	14	55625310	55625310	+	Silent	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:55625310T>C	ENST00000247191.2	-	14	2019	c.1803A>G	c.(1801-1803)ccA>ccG	p.P601P	DLGAP5_ENST00000395425.2_Silent_p.P601P	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	601					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding	p.P601P(1)		biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						CAACTTCCTTTGGTATCACAG	0.348000													16	76					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38658896	38658896	+	RNA	SNP	A	A	G	rs147623826	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:38658896A>G	ENST00000494540.1	+	0	740					NR_003086.1																						CTTTTTTGCAAATGCATTCAC	0.299000													4	78					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25261605	25261605	+	Silent	SNP	C	C	T	rs2228978	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr20:25261605C>T	ENST00000216962.4	+	11	1370	c.1260C>T	c.(1258-1260)ccC>ccT	p.P420P		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	420					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	CGCTGTTTCCCGGCGATGTGG	0.642000													7	106					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47280724	47280724	+	Translation_Start_Site	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:47280724C>A	ENST00000467728.1	+	0	1195				NR1H3_ENST00000481889.2_Intron|NR1H3_ENST00000405576.1_Intron|NR1H3_ENST00000405853.3_Intron|NR1H3_ENST00000529540.1_Intron|NR1H3_ENST00000407404.1_Intron|NR1H3_ENST00000441012.2_Intron|NR1H3_ENST00000395397.3_Intron			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3						apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						CTGGGTCCTTCCTGCAGGACA	0.517000													14	265					2.23348e-06	2.4835e-06	1	1	0
PRR23A	729627	broad.mit.edu	37	3	138724757	138724757	+	Silent	SNP	C	C	G	rs11924188	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:138724757C>G	ENST00000383163.2	-	1	353	c.354G>C	c.(352-354)tcG>tcC	p.S118S	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	118										endometrium(3)|kidney(1)|lung(7)	11						GCCCAGCAGACGAGTCGTCCT	0.617000													14	90					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532807	92532807	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:92532807G>T	ENST00000298047.6	+	9	6645	c.6628G>T	c.(6628-6630)Gcc>Tcc	p.A2210S	FAT3_ENST00000525166.1_Missense_Mutation_p.A2060S|FAT3_ENST00000409404.2_Missense_Mutation_p.A2210S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2210	Cadherin 20.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGCATCAATGCCACCAGTCC	0.413000										TCGA Ovarian(4;0.039)			7	111					1.12685e-05	1.21667e-05	1	1	0
KRT76	51350	broad.mit.edu	37	12	53162498	53162498	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:53162498C>T	ENST00000332411.2	-	9	1969	c.1916G>A	c.(1915-1917)tGa>tAa	p.*639*		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	0					cytoskeleton organization	keratin filament	structural molecule activity	p.*639*(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AACAGTAGATCACTTGGTGGA	0.517000													50	261					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78697880	78697880	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:78697880T>A	ENST00000334082.6	-	6	1970		c.e6-2		HOMER1_ENST00000508576.1_Intron|HOMER1_ENST00000282260.6_Intron|HOMER1_ENST00000535690.1_Splice_Site	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)						activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		ATTGCTGAACTAAAATAAAAC	0.408000													3	22					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133219900	133219900	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:133219900G>C	ENST00000320574.5	-	35	4504	c.4461C>G	c.(4459-4461)atC>atG	p.I1487M	POLE_ENST00000535270.1_Missense_Mutation_p.I1460M	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1487					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding	p.I1487M(2)		NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGTACAGGTAGATATGGCGGA	0.592000								DNA polymerases (catalytic subunits)					71	59					0	0	1	0	0
SLC25A33	84275	broad.mit.edu	37	1	9613721	9613721	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:9613721C>T	ENST00000302692.6	+	2	304	c.94C>T	c.(94-96)Cta>Tta	p.L32L		NM_032315.2	NP_115691.1	Q9BSK2	S2533_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	32					transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CACTTGTCCACTAGAAGTCAT	0.458000													87	583					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160273	132160273	+	Missense_Mutation	SNP	G	G	A	rs145695346	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chrX:132160273G>A	ENST00000511190.1	-	6	2445	c.1976C>T	c.(1975-1977)aCg>aTg	p.T659M	USP26_ENST00000406273.1_Missense_Mutation_p.T659M|USP26_ENST00000370832.1_Missense_Mutation_p.T659M	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	659					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					TTCCAGATACGTCATTAAGTG	0.418000													6	127					0	0	1	0	0
CASP14	23581	broad.mit.edu	37	19	15164766	15164766	+	Nonsense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:15164766G>T	ENST00000427043.3	+	4	708	c.400G>T	c.(400-402)Gga>Tga	p.G134*	CASP14_ENST00000221740.1_Nonsense_Mutation_p.G134*	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	134					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity	p.G134*(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						GGCCTGTCGAGGAGGTGGGGA	0.522000													64	141					2.94687e-45	3.68978e-45	1	1	0
RSPO1	284654	broad.mit.edu	37	1	38079565	38079565	+	Splice_Site	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:38079565C>A	ENST00000356545.2	-	7	1224		c.e7-1		RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000373059.1_Splice_Site|RSPO1_ENST00000401068.1_Splice_Site|RSPO1_ENST00000401069.1_Splice_Site|RSPO1_ENST00000401070.1_Intron	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1						positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCACATTGCGCTGGCAGGAAG	0.607000													7	62					0.307466	0.309543	1	1	0
RAET1G	353091	broad.mit.edu	37	6	150240312	150240312	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:150240312T>A	ENST00000367360.2	-	3	565	c.498A>T	c.(496-498)agA>agT	p.R166S	RP11-244K5.8_ENST00000606915.1_RNA|RP11-244K5.1_ENST00000446954.1_RNA|RAET1G_ENST00000479265.1_Missense_Mutation_p.R166S|RP11-244K5.1_ENST00000605899.1_RNA	NM_001001788.2	NP_001001788.2	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G	166	MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding	p.R166S(1)		NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|urinary_tract(1)	13		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CTTTCATCTTTCTGGCTCCAG	0.473000													85	280					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51935825	51935825	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:51935825G>T	ENST00000371117.3	-	9	921	c.646C>A	c.(646-648)Cat>Aat	p.H216N	PKHD1_ENST00000340994.4_Missense_Mutation_p.H216N	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	216	IPT/TIG 2.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.H216N(2)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCTTCCACATGGCACTGCAGA	0.413000													36	166					4.07013e-28	4.9709e-28	1	1	0
SH3RF1	57630	broad.mit.edu	37	4	170077770	170077770	+	Missense_Mutation	SNP	C	C	G	rs144629121	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:170077770C>G	ENST00000284637.9	-	3	795	c.454G>C	c.(454-456)Gac>Cac	p.D152H	SH3RF1_ENST00000508685.1_5'UTR	NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	152	SH3 1.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		AATTTAAGGTCTCCAGGCTCT	0.373000													12	96					0	0	1	0	0
UTP18	51096	broad.mit.edu	37	17	49340732	49340732	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:49340732A>G	ENST00000225298.7	+	2	497	c.440A>G	c.(439-441)gAt>gGt	p.D147G		NM_016001.2	NP_057085.2	Q9Y5J1	UTP18_HUMAN	UTP18 small subunit (SSU) processome component homolog (yeast)	147					rRNA processing	nucleolus		p.D147G(1)		breast(2)|endometrium(3)|kidney(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			GATGAAGAAGATGAAGATGAG	0.358000													38	154					0	0	1	0	0
RAB28	9364	broad.mit.edu	37	4	13378197	13378197	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:13378197A>T	ENST00000288723.4	-	6	759	c.545T>A	c.(544-546)tTa>tAa	p.L182*	RAB28_ENST00000330852.5_Nonsense_Mutation_p.L182*|RAB28_ENST00000338176.4_Nonsense_Mutation_p.L182*	NM_004249.3	NP_004240.2	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family	182					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	8						TGCTTTGTTTAATTTGATCCC	0.303000													4	56					0	0	1	0	0
SAG	6295	broad.mit.edu	37	2	234255451	234255451	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:234255451A>T	ENST00000409110.1	+	16	1342		c.e16-1			NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)						rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		GTTTTATTTTAGTTATCAGGA	0.388000													7	44					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98165090	98165090	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:98165090A>T	ENST00000370192.3	-	6	597	c.497T>A	c.(496-498)aTg>aAg	p.M166K	DPYD_ENST00000423006.2_3'UTR|DPYD_ENST00000474241.1_5'UTR	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	166			M -> V (in dbSNP:rs2297595).		'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGGGATACTCATTGCTTTGAA	0.388000													8	101					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793714	17793714	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:17793714T>C	ENST00000379472.3	+	2	1103	c.1073T>C	c.(1072-1074)aTc>aCc	p.I358T	KCNC1_ENST00000265969.6_Missense_Mutation_p.I358T	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	358						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.I358T(2)		breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGCGTGCTGATCTTCGCCACC	0.612000													26	61					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670844	37670844	+	Missense_Mutation	SNP	T	T	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:37670844T>G	ENST00000422441.1	+	16	2116	c.1856T>G	c.(1855-1857)cTc>cGc	p.L619R	ITGA9_ENST00000264741.5_Intron			Q13797	ITA9_HUMAN	integrin, alpha 9	0					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		ACCTTAAAGCTCATACTCAGC	0.547000													5	22					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152711518	152711518	+	Missense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:152711518A>T	ENST00000367255.5	-	53	8675	c.8074T>A	c.(8074-8076)Ttg>Atg	p.L2692M	SYNE1_ENST00000265368.4_Missense_Mutation_p.L2692M|SYNE1_ENST00000423061.1_Missense_Mutation_p.L2699M|SYNE1_ENST00000341594.5_Missense_Mutation_p.L2731M|SYNE1_ENST00000448038.1_Missense_Mutation_p.L2699M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2692					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.L2692M(2)|p.L2699M(1)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTACTTCTCAAGGCCTGTTCC	0.473000										HNSCC(10;0.0054)			11	123					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31549617	31549617	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:31549617G>T	ENST00000429299.2	-	2	189	c.182C>A	c.(181-183)cCc>cAc	p.P61H	LTB_ENST00000483972.1_Intron|LTB_ENST00000446745.2_Intron	NM_002341.1	NP_002332.1	Q06643	TNFC_HUMAN	lymphotoxin beta (TNF superfamily, member 3)	61				DPGAQAQQGL -> GLSAPGSGRT (in Ref. 2; AAB37342).	cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9					Infliximab(DB00065)|Simvastatin(DB00641)	CTGTGCCCCGGGGTCGGCCGT	0.627000													12	84					8.60227e-14	1.00136e-13	1	1	0
MFAP3L	9848	broad.mit.edu	37	4	170912627	170912627	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:170912627C>A	ENST00000361618.3	-	3	1439	c.1132G>T	c.(1132-1134)Gta>Tta	p.V378L	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.V275L	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	378						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TTATCTGGTACCTCAACAGGT	0.502000													38	497					2.40579e-17	2.84494e-17	1	1	0
PRKAR2B	5577	broad.mit.edu	37	7	106793620	106793620	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:106793620A>T	ENST00000265717.4	+	8	1102		c.e8-1			NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						CTTTCTTTGTAGTTTTCTGAA	0.333000													4	44					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109772058	109772058	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:109772058A>G	ENST00000369923.4	+	4	322	c.311A>G	c.(310-312)aAa>aGa	p.K104R	SARS_ENST00000234677.2_Missense_Mutation_p.K104R			P49591	SYSC_HUMAN	seryl-tRNA synthetase	104					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity	p.K104R(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TCACAAATCAAAAAAGTCCGA	0.502000													78	639					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55223621	55223621	+	Missense_Mutation	SNP	G	G	A	rs139429793		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:55223621G>A	ENST00000275493.2	+	8	1165	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	EGFR_ENST00000442591.1_Missense_Mutation_p.E330K|EGFR_ENST00000342916.3_Missense_Mutation_p.E330K|EGFR_ENST00000454757.2_Missense_Mutation_p.E277K|EGFR_ENST00000455089.1_Missense_Mutation_p.E285K|EGFR_ENST00000344576.2_Missense_Mutation_p.E330K|EGFR_ENST00000420316.2_Missense_Mutation_p.E330K	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	330					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAGAAGTGCGAAGGGCCTTG	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			22	21					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197168567	197168567	+	Missense_Mutation	SNP	T	T	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:197168567T>C	ENST00000367405.4	-	1	1105	c.1037A>G	c.(1036-1038)gAg>gGg	p.E346G	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E346G(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AGTTAACCCCTCATGAACATT	0.373000													48	154					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47738989	47738989	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:47738989C>T	ENST00000263773.5	-	17	3051	c.3039G>A	c.(3037-3039)atG>atA	p.M1013I		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	1013								p.M1013I(1)|p.M1013_A1014>IS(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						TGTTTGGAGCCATTTTCCTTC	0.333000													10	124					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14200007	14200007	+	Missense_Mutation	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:14200007T>A	ENST00000285021.7	-	9	1590	c.1376A>T	c.(1375-1377)gAt>gTt	p.D459V	XPC_ENST00000449060.2_Missense_Mutation_p.D422V	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	459	Asp/Glu-rich (acidic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding	p.D459V(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGTTCGGAATCCTCATCAGA	0.577000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				10	30					0	0	1	0	0
CGA	1081	broad.mit.edu	37	6	87795978	87795978	+	Nonsense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:87795978G>T	ENST00000369582.2	-	3	363	c.263C>A	c.(262-264)tCa>tAa	p.S88*		NM_000735.3	NP_000726.1	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	88					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)	15		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		CCTGTTATATGATTTAGCTAC	0.453000													8	169					1.12685e-05	1.21667e-05	1	1	0
DST	667	broad.mit.edu	37	6	56373370	56373370	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:56373370C>A	ENST00000370754.5	-	75	19102	c.19103G>T	c.(19102-19104)gGa>gTa	p.G6368V	DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.G5864V|DST_ENST00000370769.4_Missense_Mutation_p.G6190V|DST_ENST00000244364.6_Missense_Mutation_p.G3776V|DST_ENST00000340834.4_5'UTR|DST_ENST00000361203.3_Missense_Mutation_p.G6079V|DST_ENST00000421834.2_Missense_Mutation_p.G4102V|DST_ENST00000370788.2_Missense_Mutation_p.G3993V			Q03001	DYST_HUMAN	dystonin	6188					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGGATCAATTCCAGGATCTTC	0.378000													12	243					9.31168e-06	1.02018e-05	1	1	0
YTHDC2	64848	broad.mit.edu	37	5	112884236	112884236	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:112884236A>T	ENST00000161863.4	+	11	1708		c.e11-1		YTHDC2_ENST00000515883.1_Splice_Site	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2								ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TCCTTTTTTTAGTTGATTACA	0.348000													4	28					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155300229	155300229	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:155300229G>T	ENST00000368352.5	+	10	2727	c.2576G>T	c.(2575-2577)aGa>aTa	p.R859I	RUSC1_ENST00000368347.4_Missense_Mutation_p.R449I|RUSC1_ENST00000462780.1_3'UTR|RUSC1_ENST00000368354.3_Missense_Mutation_p.R753I|RUSC1_ENST00000292254.4_Missense_Mutation_p.R390I|RUSC1_ENST00000368349.4_Missense_Mutation_p.R390I	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	859	SH3.					cytoplasm|nucleolus	SH3/SH2 adaptor activity	p.R449I(1)|p.R390I(1)|p.R753I(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ACTGCTGCAAGACCTGACCAG	0.642000													34	514					3.09479e-21	3.68899e-21	1	1	0
GFOD2	81577	broad.mit.edu	37	16	67709603	67709603	+	Missense_Mutation	SNP	C	C	T	rs147012796		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr16:67709603C>T	ENST00000268797.7	-	3	958	c.613G>A	c.(613-615)Gtg>Atg	p.V205M	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	205						proteinaceous extracellular matrix	binding|oxidoreductase activity	p.V205M(1)		breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TTCTGCCTCACGAATGTCTTG	0.612000													5	78					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369428	56369428	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:56369428G>A	ENST00000301295.6	+	3	1091	c.669G>A	c.(667-669)ccG>ccA	p.P223P	NLRP4_ENST00000587891.1_Silent_p.P148P|NLRP4_ENST00000346986.5_Silent_p.P223P	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	223	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGTCTCAACCGGAGAGACTCT	0.557000													22	76					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961026	1961026	+	Silent	SNP	C	C	A	rs150953132		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr20:1961026C>A	ENST00000217305.2	-	4	933	c.708G>T	c.(706-708)gtG>gtT	p.V236V	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Silent_p.V236V|PDYN_ENST00000539905.1_Silent_p.V236V	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	236					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ACCGAGTCACCACCTTGAACT	0.527000													11	295					0.00136819	0.0014256	1	1	0
CHRNE	1145	broad.mit.edu	37	17	4804298	4804298	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:4804298G>A	ENST00000293780.4	-	7	799	c.789C>T	c.(787-789)ttC>ttT	p.F263F	C17orf107_ENST00000381365.3_3'UTR	NM_000080.3	NP_000071.1	Q04844	ACHE_HUMAN	cholinergic receptor, nicotinic, epsilon (muscle)	263					muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.F263F(1)		central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)	12						GCGCCGGCAGGAAGTAGGCGA	0.657000													9	39					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64827305	64827305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:64827305C>T	ENST00000332707.5	+	19	2903	c.2374C>T	c.(2374-2376)Cag>Tag	p.Q792*		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	792	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.Q792*(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		TTTAGAGAAGCAGATGTTGCG	0.468000													25	387					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450450	55450450	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:55450450C>A	ENST00000588756.1	-	6	2223	c.1737G>T	c.(1735-1737)caG>caT	p.Q579H	NLRP7_ENST00000448121.2_Missense_Mutation_p.Q579H|NLRP7_ENST00000340844.2_Missense_Mutation_p.Q579H|NLRP7_ENST00000592784.1_Missense_Mutation_p.Q579H|NLRP7_ENST00000328092.5_Missense_Mutation_p.Q579H|NLRP7_ENST00000590030.1_Missense_Mutation_p.Q579H|NLRP7_ENST00000446217.1_Missense_Mutation_p.Q607H			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	579							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GCTCCTCCTCCTGAGACTCAT	0.493000													75	503					2.35497e-27	2.85277e-27	1	1	0
ATG2B	55102	broad.mit.edu	37	14	96756058	96756058	+	Missense_Mutation	SNP	G	G	C	rs144991946	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:96756058G>C	ENST00000359933.4	-	41	6834	c.5941C>G	c.(5941-5943)Cgg>Ggg	p.R1981G		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1981										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGGGCTAACCGGTGATGAGGA	0.502000													29	346					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17029462	17029462	+	RNA	SNP	A	A	G	rs11260891	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:17029462A>G	ENST00000492551.1	-	0	903					NR_026567.1																						CTAGTGCTGGAAAGCCCTGGG	0.577000													7	19					0	0	1	0	0
PEX7	5191	broad.mit.edu	37	6	137167252	137167252	+	Silent	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:137167252C>A	ENST00000541292.1	+	5	545	c.459C>A	c.(457-459)ggC>ggA	p.G153G	PEX7_ENST00000318471.4_Silent_p.G153G			O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	153					ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding			lung(7)|prostate(1)	8	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		CCTTTAGAGGCCATGAAAGTA	0.363000													5	97					0.00307968	0.00318661	1	1	0
SMC3	9126	broad.mit.edu	37	10	112356197	112356197	+	Missense_Mutation	SNP	T	T	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:112356197T>G	ENST00000361804.4	+	19	2131	c.2005T>G	c.(2005-2007)Tat>Gat	p.Y669D		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	669					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity	p.Y669D(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TGGGGGTTATTATGACACAAG	0.383000													69	123					0	0	1	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967381	31967381	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr20:31967381A>T	ENST00000357886.4	-	9	1188	c.1035T>A	c.(1033-1035)taT>taA	p.Y345*	CDK5RAP1_ENST00000452723.3_Nonsense_Mutation_p.Y241*|CDK5RAP1_ENST00000339269.5_Intron|CDK5RAP1_ENST00000473997.1_5'UTR|CDK5RAP1_ENST00000346416.2_Nonsense_Mutation_p.Y331*|CDK5RAP1_ENST00000544843.1_Nonsense_Mutation_p.Y331*			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	345					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						GCTTGGTTTTATAGTTGGTGG	0.473000													7	145					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105635195	105635195	+	Splice_Site	SNP	A	A	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:105635195A>T	ENST00000542731.1	+	5	621		c.e5-1		CDHR3_ENST00000470188.1_Intron|CDHR3_ENST00000541203.1_Intron|CDHR3_ENST00000317716.9_Splice_Site|CDHR3_ENST00000478080.1_Splice_Site|CDHR3_ENST00000343407.5_Splice_Site			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CTTGTTTTTTAGTATTTCCTG	0.438000													3	16					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545342	234545342	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:234545342C>T	ENST00000344644.5	+	1	243	c.174C>T	c.(172-174)gtC>gtT	p.V58V	UGT1A10_ENST00000373445.1_Silent_p.V58V|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1												p.V58V(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGTTGTAGTCATGCCAGAGG	0.517000													13	256					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48523269	48523269	+	Silent	SNP	G	G	A	rs148068614	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr20:48523269G>A	ENST00000422556.1	-	3	799	c.450C>T	c.(448-450)ctC>ctT	p.L150L	SPATA2_ENST00000543716.1_Silent_p.L13L|SPATA2_ENST00000289431.5_Silent_p.L150L	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	150					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			CGAGCTCTCTGAGCTTGTATG	0.502000													7	165					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47738988	47738988	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:47738988C>A	ENST00000263773.5	-	17	3052	c.3040G>T	c.(3040-3042)Gct>Tct	p.A1014S		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	1014								p.M1013_A1014>IS(1)|p.A1014S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						GTGTTTGGAGCCATTTTCCTT	0.333000													10	121					1.58986e-06	1.78113e-06	1	1	0
PHLPP2	23035	broad.mit.edu	37	16	71682850	71682850	+	Silent	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr16:71682850A>G	ENST00000393524.2	-	17	4447	c.3714T>C	c.(3712-3714)ccT>ccC	p.P1238P	PHLPP2_ENST00000568954.1_Silent_p.P1305P|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000356272.3_Silent_p.P1305P|PHLPP2_ENST00000567016.1_Silent_p.P1340P|PHLPP2_ENST00000540628.1_Intron			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1305						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity	p.P1305P(1)		central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CATGGGGCTCAGGCTCGAGCC	0.582000													54	91					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10795708	10795708	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:10795708G>A	ENST00000361367.2	+	22	3303	c.2877G>A	c.(2875-2877)aaG>aaA	p.K959K		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	959	Lys-rich.|Poly-Lys.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		agaagaaaaagaggagaagGT	0.368000													24	73					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136837	80136837	+	Silent	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:80136837C>A	ENST00000466387.1	+	11	1694	c.970C>A	c.(970-972)Cga>Aga	p.R324R	CTNNA2_ENST00000402739.4_Silent_p.R324R|CTNNA2_ENST00000541047.1_Silent_p.R324R|CTNNA2_ENST00000540488.1_Silent_p.R324R|CTNNA2_ENST00000496558.1_Silent_p.R324R|CTNNA2_ENST00000361291.4_Silent_p.R358R			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	324					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.R324R(2)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCCTGCACGCGAGACGACCG	0.647000													31	96					3.88204e-17	4.55452e-17	1	1	0
SLC7A10	56301	broad.mit.edu	37	19	33702235	33702235	+	Splice_Site	SNP	C	C	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:33702235C>G	ENST00000253188.3	-	7	1059		c.e7-1			NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity	p.?(1)		central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					CCCCGAAGGTCTGGGTGGGCA	0.617000													7	24					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292785	102292785	+	RNA	SNP	C	C	G	rs61084368		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:102292785C>G	ENST00000561463.1	+	0	831																		p.Q125E(1)									TGCTGCTTCTCAGAGCTGCTG	0.602000													6	5					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103560981	103560981	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:103560981C>T	ENST00000226578.4	-	14	2002	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K	MANBA_ENST00000505239.1_Missense_Mutation_p.E578K	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	635					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CGGTAGAATTCAGTTTCTGTT	0.468000													5	63					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40866017	40866017	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:40866017G>C	ENST00000315616.7	+	3	1233	c.1195G>C	c.(1195-1197)Ggc>Cgc	p.G399R	RPUSD2_ENST00000559271.1_Missense_Mutation_p.G338R	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	399					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding	p.G399R(1)		kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TCCTTCTCGAGGCCGGGGCGG	0.572000													71	202					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223940635	223940635	+	Missense_Mutation	SNP	C	C	T	rs145466296	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:223940635C>T	ENST00000295006.5	+	9	1421	c.1112C>T	c.(1111-1113)gCg>gTg	p.A371V	CAPN2_ENST00000433674.2_Missense_Mutation_p.A293V	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	371	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGCTCCACCGCGGGAGGTTGC	0.567000													9	163					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39051932	39051932	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:39051932G>A	ENST00000355481.4	+	89	12578	c.12447G>A	c.(12445-12447)ccG>ccA	p.P4149P	RYR1_ENST00000359596.3_Silent_p.P4154P|RYR1_ENST00000360985.3_Silent_p.P4149P	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4154					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.P4154P(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCATGTGCCGCATGACCCTC	0.627000													202	455					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5838827	5838827	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:5838827T>A	ENST00000380191.4	-	3	444		c.e3-2		GDI2_ENST00000380132.4_Splice_Site|GDI2_ENST00000380181.3_Splice_Site	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2						protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						TTTGTATAACTAAAAGCAAGG	0.308000													4	33					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72532300	72532300	+	Missense_Mutation	SNP	T	T	C	rs143899859	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:72532300T>C	ENST00000299290.1	-	10	1329	c.940A>G	c.(940-942)Ata>Gta	p.I314V		NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AAAGGTGATATCTTCGTTTTC	0.512000													25	365					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708271	36708271	+	Missense_Mutation	SNP	A	A	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:36708271A>C	ENST00000264659.7	-	14	2802	c.2578T>G	c.(2578-2580)Ttc>Gtc	p.F860V	SRCIN1_ENST00000578925.1_Missense_Mutation_p.F894V|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	732	Pro-rich.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding	p.F860V(1)		endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						GGCATTTCGAAGTCCACGCTC	0.617000													23	35					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100887766	100887766	+	Missense_Mutation	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr8:100887766G>T	ENST00000358544.2	+	62	12052	c.11941G>T	c.(11941-11943)Gtg>Ttg	p.V3981L	VPS13B_ENST00000357162.2_Missense_Mutation_p.V3956L|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3981					protein transport			p.V3981L(1)|p.V3956L(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATGCCCTGTGGTGGCTGCAGA	0.468000													11	214					4.93089e-13	5.65156e-13	1	1	0
RELN	5649	broad.mit.edu	37	7	103132475	103132475	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:103132475T>A	ENST00000424685.2	-	58	9529		c.e58-2		CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000428762.1_Splice_Site|RELN_ENST00000343529.5_Splice_Site			P78509	RELN_HUMAN	reelin						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCACAATCTAAAACAAACA	0.333000													4	30					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39553696	39553696	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:39553696G>A	ENST00000251645.2	-	1	148	c.96C>T	c.(94-96)ccC>ccT	p.P32P		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	32	Head.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				TGCAGGCCCCGGGCAGGGTGC	0.637000													11	267					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120900686	120900686	+	Silent	SNP	T	T	C	rs61730480	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:120900686T>C	ENST00000263713.5	+	19	1921	c.1707T>C	c.(1705-1707)gcT>gcC	p.A569A	EPB41L5_ENST00000443902.2_Silent_p.A569A|EPB41L5_ENST00000452780.1_Silent_p.A569A	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	569						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TTTTGAAGGCTCAAGTAGAAG	0.428000													15	442					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117681127	117681127	+	Silent	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:117681127C>T	ENST00000317775.6	-	19	3622	c.2937G>A	c.(2935-2937)gtG>gtA	p.V979V	NOS1_ENST00000338101.4_Silent_p.V1013V|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	979					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.V979V(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GAGCTTCGGCCACAAAGGTGA	0.517000													52	473					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48977501	48977501	+	Missense_Mutation	SNP	G	G	A	rs1804728		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:48977501G>A	ENST00000427476.1	+	7	910	c.610G>A	c.(610-612)Gtc>Atc	p.V204I	CYTH2_ENST00000452733.2_Missense_Mutation_p.V204I	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	204					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding	p.V204I(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						CAATCCCAATGTCCGGGACAA	0.632000													57	139					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160062372	160062372	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:160062372C>A	ENST00000368086.1	-	5	1642	c.1426G>T	c.(1426-1428)Gcc>Tcc	p.A476S	IGSF8_ENST00000314485.7_Missense_Mutation_p.A476S			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	476	Ig-like C2-type 4.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CAGCTGGCGGCCAGCCGCAGT	0.687000													5	75					0.014758	0.0150612	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96106258	96106258	+	Silent	SNP	G	G	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:96106258G>T	ENST00000453304.1	-	13	2574	c.2226C>A	c.(2224-2226)cgC>cgA	p.R742R		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	742					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAATTGACAGGCGCAGGTTGT	0.458000													36	180					1.43246e-33	1.77864e-33	1	1	0
DPY19L1	23333	broad.mit.edu	37	7	34981390	34981390	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:34981390A>G	ENST00000310974.4	-	18	1601	c.1457T>C	c.(1456-1458)aTc>aCc	p.I486T		NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	486						integral to membrane		p.I486T(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						TCTTGAGCAGATCAGTGATGC	0.343000													13	42					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554161	140554161	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:140554161C>T	ENST00000231137.3	+	1	1919	c.1745C>T	c.(1744-1746)cCg>cTg	p.P582L		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		582	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P582L(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCCGAGCCGGGCTACCTG	0.697000													7	22					0	0	1	0	0
ALG3	10195	broad.mit.edu	37	3	183960405	183960405	+	Missense_Mutation	SNP	C	C	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:183960405C>T	ENST00000455059.1	-	9	1548	c.1094G>A	c.(1093-1095)aGc>aAc	p.S365N	ALG3_ENST00000397676.3_Missense_Mutation_p.S405N|ALG3_ENST00000418734.2_Missense_Mutation_p.S349N|EIF2B5_ENST00000444495.1_Intron|ALG3_ENST00000445626.2_Missense_Mutation_p.S357N			Q92685	ALG3_HUMAN	ALG3, alpha-1,3- mannosyltransferase	405					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCAGCAGAGCTGCAGGATGT	0.572000													5	99					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31484489	31484489	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:31484489G>A	ENST00000322054.5	+	5	1275	c.990G>A	c.(988-990)gaG>gaA	p.E330E	EHD3_ENST00000541626.1_Intron	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	330					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding	p.E330E(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					AGAAGAAGGAGCTGGTCAACA	0.572000													203	86					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61840378	61840378	+	Splice_Site	SNP	T	T	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:61840378T>A	ENST00000280772.1	-	36	4542		c.e36-2		ANK3_ENST00000355288.2_Splice_Site|ANK3_ENST00000373827.2_Splice_Site|ANK3_ENST00000503366.1_Splice_Site	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTCAATCTGAAAAGGAAA	0.378000													4	56					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507132	64507132	+	Missense_Mutation	SNP	G	G	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:64507132G>C	ENST00000377494.1	-	6	1594	c.672C>G	c.(670-672)atC>atG	p.I224M	RASGRP2_ENST00000377497.3_Missense_Mutation_p.I224M|RASGRP2_ENST00000354024.3_Missense_Mutation_p.I224M|RASGRP2_ENST00000394432.3_Missense_Mutation_p.I224M			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	224	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity	p.I286M(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAAAGTGTGTGATGACCAGGG	0.637000													22	61					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67559027	67559027	+	Silent	SNP	C	C	T	rs139606703		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:67559027C>T	ENST00000371007.2	-	8	973	c.864G>A	c.(862-864)gcG>gcA	p.A288A	C1orf141_ENST00000544837.1_Silent_p.A288A|C1orf141_ENST00000371006.1_Silent_p.A288A	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	288										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TTGTGTGGCCCGCTTTAAAAG	0.323000													6	51					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33091085	33091085	+	Silent	SNP	G	G	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:33091085G>A	ENST00000334528.9	-	15	3380	c.3381C>T	c.(3379-3381)taC>taT	p.Y1127Y	FMN1_ENST00000559047.1_Silent_p.Y1350Y|FMN1_ENST00000561249.1_Silent_p.Y1252Y	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	1350	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCATAAACACGTAGCTGGGTG	0.403000													5	101					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63030443	63030443	+	Missense_Mutation	SNP	A	A	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:63030443A>G	ENST00000561311.1	+	29	3828	c.3598A>G	c.(3598-3600)Aac>Gac	p.N1200D	TLN2_ENST00000559908.1_3'UTR|TLN2_ENST00000306829.6_Missense_Mutation_p.N1200D			Q9Y4G6	TLN2_HUMAN	talin 2	1200					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton	p.N1200D(1)		NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTCCTTGAATAACTGCGTAAA	0.502000													237	171					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103452870	103452870	+	Missense_Mutation	SNP	C	C	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:103452870C>A	ENST00000361246.2	-	6	932	c.644G>T	c.(643-645)cGc>cTc	p.R215L		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	215	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GTCAGCCAGGCGGATATGACC	0.378000													19	288					0.667858	0.667858	1	1	0
ARHGAP27	201176	broad.mit.edu	37	17	43481848	43481848	+	Missense_Mutation	SNP	C	C	A	rs149944561	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:43481848C>A	ENST00000532038.1	-	5	911	c.776G>T	c.(775-777)gGt>gTt	p.G259V	ARHGAP27_ENST00000376922.2_Missense_Mutation_p.G118V|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.G459V|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.G459V|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.G91V|ARHGAP27_ENST00000455881.1_Missense_Mutation_p.G118V|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.G432V			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	459	WW 1.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					TGGGGTGTCACCATCCTGGCT	0.607000													4	37					0.014758	0.0150612	1	1	0
SSU72	29101	broad.mit.edu	37	1	1500119	1500120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:1500119_1500120insG	ENST00000359060.4	-	2	283_284	c.257_258insC	c.(256-258)ctgfs	p.L86fs	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GAGGACCACACGGGGGGTTTTT	0.505													11	616	---	---	---	---					
KIAA2013	90231	broad.mit.edu	37	1	11983199	11983200	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:11983199_11983200insC	ENST00000376572.3	-	2	1565_1566	c.1380_1381insG	c.(1378-1383)ggtgcafs	p.A461fs	KIAA2013_ENST00000376576.3_Frame_Shift_Ins_p.A461fs	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	461						integral to membrane		p.G460G(1)		endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGAACTGCAGCCCCCCAAAGC	0.604													7	501	---	---	---	---					
VPS13D	55187	broad.mit.edu	37	1	12422832	12422833	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:12422832_12422833insC	ENST00000358136.3	+	51	10328_10329	c.10198_10199insC	c.(10198-10200)cccfs	p.P3400fs	VPS13D_ENST00000356315.4_Frame_Shift_Ins_p.P3375fs	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3399					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGTCATCTTTGCCCCCCGTTAC	0.426													11	481	---	---	---	---					
PADI3	51702	broad.mit.edu	37	1	17603074	17603075	+	Frame_Shift_Ins	INS	-	-	C	rs148039282	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:17603074_17603075insC	ENST00000375460.3	+	12	1408_1409	c.1368_1369insC	c.(1366-1371)caccccfs	p.HP456fs		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	456					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGAAGGTGCAGCCCCCCGTGGA	0.564													8	587	---	---	---	---					
IGSF21	84966	broad.mit.edu	37	1	18554419	18554420	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:18554419_18554420insC	ENST00000251296.1	+	2	481_482	c.98_99insC	c.(97-99)cccfs	p.P33fs		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	33	Ig-like 1.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		ATTGAGCCTCTCCCCCCTGTGG	0.574													8	541	---	---	---	---					
EPHB2	2048	broad.mit.edu	37	1	23222908	23222909	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:23222908_23222909insG	ENST00000374632.3	+	9	1718_1719	c.1705_1706insG	c.(1705-1707)gggfs	p.G569fs	EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374627.1_Splice_Site_p.G563_splice|EPHB2_ENST00000400191.3_Splice_Site_p.G568_splice|EPHB2_ENST00000374630.3_Splice_Site_p.G568_splice			P29323	EPHB2_HUMAN	EPH receptor B2	568					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity	p.R568W(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TTCCAGAAGACGGGGGTTTGAG	0.614													7	659	---	---	---	---					
LUZP1	7798	broad.mit.edu	37	1	23417944	23417945	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:23417944_23417945insG	ENST00000302291.4	-	4	3611_3612	c.2810_2811insC	c.(2809-2811)cacfs	p.H937fs	LUZP1_ENST00000314174.5_Frame_Shift_Ins_p.H937fs|LUZP1_ENST00000374623.3_Frame_Shift_Ins_p.H937fs|LUZP1_ENST00000418342.1_Frame_Shift_Ins_p.H937fs			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	937						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CTATTCGAGTTGGGGGGTCTTC	0.495													12	429	---	---	---	---					
LUZP1	7798	broad.mit.edu	37	1	23419318	23419319	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:23419318_23419319insG	ENST00000302291.4	-	4	2237_2238	c.1436_1437insC	c.(1435-1437)cgcfs	p.R479fs	LUZP1_ENST00000314174.5_Frame_Shift_Ins_p.R479fs|LUZP1_ENST00000374623.3_Frame_Shift_Ins_p.R479fs|LUZP1_ENST00000418342.1_Frame_Shift_Ins_p.R479fs			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	479						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CCTGAGCAGCCGGGGGGTAGCG	0.569													10	508	---	---	---	---					
STPG1	90529	broad.mit.edu	37	1	24700193	24700194	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:24700193_24700194insG	ENST00000374409.1	-	6	823_824	c.571_splice	c.e6+1	p.R190_splice	STPG1_ENST00000440416.1_Splice_Site_p.R143_splice|STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Splice_Site_p.R190_splice|STPG1_ENST00000003583.8_Splice_Site_p.R143_splice	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		GCTGCTTACCTGGGGGAGGTCC	0.485													10	2473	---	---	---	---					
LDLRAP1	26119	broad.mit.edu	37	1	25889626	25889627	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:25889626_25889627insC	ENST00000374338.4	+	6	717_718	c.598_599insC	c.(598-600)cccfs	p.P200fs	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	200					amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		CCAAGACTGCACCCCCTCCTTG	0.634													10	156	---	---	---	---					
RPS6KA1	6195	broad.mit.edu	37	1	26885310	26885311	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:26885310_26885311insC	ENST00000374168.2	+	14	1251_1252	c.1097_1098insC	c.(1096-1098)accfs	p.T366fs	RPS6KA1_ENST00000374162.2_Frame_Shift_Ins_p.T274fs|RPS6KA1_ENST00000374166.4_Frame_Shift_Ins_p.T355fs|RPS6KA1_ENST00000526792.1_Frame_Shift_Ins_p.T274fs|RPS6KA1_ENST00000531382.1_Frame_Shift_Ins_p.T375fs|RPS6KA1_ENST00000530003.1_Frame_Shift_Ins_p.T350fs	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	366	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCCCCAGGCATCCCCCCCAGCG	0.673													7	214	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27101267	27101268	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:27101267_27101268insC	ENST00000324856.7	+	18	4920_4921	c.4549_4550insC	c.(4549-4551)cccfs	p.P1517fs	ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.P1134fs|ARID1A_ENST00000457599.2_Intron|ARID1A_ENST00000540690.1_Intron	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1517					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CACGGGCTCTGCCCCCCAGGGC	0.584			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								10	557	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27105930	27105931	+	Frame_Shift_Ins	INS	-	-	G	rs140055856		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:27105930_27105931insG	ENST00000324856.7	+	20	5912_5913	c.5541_5542insG	c.(5539-5544)ggggggfs	p.GG1847fs	ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.GG1464fs|ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.GG1630fs|ARID1A_ENST00000540690.1_Frame_Shift_Ins_p.GG175fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1847					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.G1848fs*6(3)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACAC	0.579			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								20	381	---	---	---	---					
WASF2	10163	broad.mit.edu	37	1	27736340	27736340	+	Frame_Shift_Del	DEL	A	A	-	rs71584884		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:27736340delA	ENST00000430629.2	-	8	1400	c.1185delT	c.(1183-1185)ccfs	p.P400fs	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	400	Poly-Pro.				actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		gaggaggaggagggggaggag	0.642													15	157	---	---	---	---					
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:28800272_28800273insC	ENST00000373839.3	+	7	1291_1292	c.1030_1031insC	c.(1030-1032)cccfs	p.P344fs	PHACTR4_ENST00000373836.3_Frame_Shift_Ins_p.P354fs|PHACTR4_ENST00000493669.1_3'UTR	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity	p.P356fs*33(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													12	506	---	---	---	---					
SDC3	9672	broad.mit.edu	37	1	31347369	31347370	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:31347369_31347370insC	ENST00000336798.7	-	2	2254_2255	c.762_763insG	c.(760-765)ggccagfs	p.Q255fs	SDC3_ENST00000339394.6_Frame_Shift_Ins_p.Q313fs			O75056	SDC3_HUMAN	syndecan 3	313	Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCACTGGGCCCCCCACTCA	0.609													8	251	---	---	---	---					
PUM1	9698	broad.mit.edu	37	1	31406073	31406074	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:31406073_31406074insG	ENST00000373747.3	-	22	3653_3654	c.3554_3555insC	c.(3553-3555)caafs	p.Q1185fs	PUM1_ENST00000440538.2_Frame_Shift_Ins_p.Q1158fs|PUM1_ENST00000426105.2_Frame_Shift_Ins_p.Q1184fs|PUM1_ENST00000424085.2_Frame_Shift_Ins_p.Q940fs|PUM1_ENST00000423018.2_Frame_Shift_Ins_p.Q1040fs|PUM1_ENST00000373741.4_Frame_Shift_Ins_p.Q1220fs|PUM1_ENST00000373742.2_Frame_Shift_Ins_p.Q1123fs|PUM1_ENST00000257075.5_Frame_Shift_Ins_p.Q1182fs	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	1182					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGATACCATTAGGGGGGCCACA	0.525													13	516	---	---	---	---					
IQCC	55721	broad.mit.edu	37	1	32673442	32673443	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:32673442_32673443insG	ENST00000537469.1	+	5	1447_1448	c.1400_1401insG	c.(1399-1401)tggfs	p.W467fs	IQCC_ENST00000291358.6_Frame_Shift_Ins_p.W387fs	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	387										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GATGGTACCTTGGGGGGGCCAG	0.550													22	383	---	---	---	---					
KIAA1522	57648	broad.mit.edu	37	1	33233494	33233495	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:33233494_33233495insC	ENST00000401073.2	+	2	412_413	c.342_343insC	c.(340-345)cgccccfs	p.RP114fs	KIAA1522_ENST00000373480.1_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000294521.3_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000373481.3_Frame_Shift_Ins_p.RP66fs	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	55			S -> P (in dbSNP:rs3737994).							breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGTGGGCGACCCCCCCACCT	0.614													13	192	---	---	---	---					
ADC	113451	broad.mit.edu	37	1	33583704	33583705	+	In_Frame_Ins	INS	-	-	TGG			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:33583704_33583705insTGG	ENST00000294517.6	+	11	1818_1819	c.1231_1232insTGG	c.(1231-1233)ccg>TGGccg	p.410_411insW	ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373443.3_In_Frame_Ins_p.410_411insW|ADC_ENST00000398167.1_In_Frame_Ins_p.430_431insW|ADC_ENST00000373441.1_In_Frame_Ins_p.430_431insW	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	410					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CTATGCCATGTCCCGGGTGGCC	0.579													7	119	---	---	---	---					
PHC2	1912	broad.mit.edu	37	1	33799791	33799792	+	Frame_Shift_Ins	INS	-	-	G	rs34753508		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:33799791_33799792insG	ENST00000257118.5	-	9	1710_1711	c.1657_1658insC	c.(1657-1659)gaafs	p.E553fs	PHC2_ENST00000431992.1_Frame_Shift_Ins_p.E524fs|PHC2_ENST00000419414.2_Frame_Shift_Ins_p.E554fs|PHC2_ENST00000485928.1_5'UTR|PHC2_ENST00000373422.3_Frame_Shift_Ins_p.E159fs|PHC2_ENST00000373416.1_Frame_Shift_Ins_p.E18fs|PHC2_ENST00000373418.3_Frame_Shift_Ins_p.E18fs	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	553					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CTCACCATTCTGGGGGGCAGTG	0.589													8	387	---	---	---	---					
CSMD2	114784	broad.mit.edu	37	1	34035115	34035116	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:34035115_34035116insG	ENST00000373381.4	-	52	8165_8166	c.7989_7990insC	c.(7987-7992)ccatggfs	p.W2664fs		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2666	Sushi 17.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGGTGGCCATTGGGGGGAATCG	0.554													7	159	---	---	---	---					
AGO1	26523	broad.mit.edu	37	1	36354044	36354045	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:36354044_36354045insC	ENST00000373204.4	+	2	255_256	c.42_43insC	c.(40-45)ctccccfs	p.LP14fs	AGO1_ENST00000373206.1_5'UTR	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GCGCTTACCTGCCCCCCCTGCA	0.569													17	184	---	---	---	---					
MAP7D1	55700	broad.mit.edu	37	1	36636763	36636764	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:36636763_36636764insC	ENST00000316156.4	+	2	691_692	c.238_239insC	c.(238-240)cccfs	p.P80fs	MAP7D1_ENST00000373151.2_Frame_Shift_Ins_p.P80fs|MAP7D1_ENST00000373150.4_Frame_Shift_Ins_p.P80fs			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	80	Pro-rich.					cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				GCCTAGGCCAGCCCCCCCGCAG	0.653													21	260	---	---	---	---					
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:36935322_36935323insG	ENST00000373103.1	-	11	1951_1952	c.1404_1405insC	c.(1402-1407)ccgcgcfs	p.R469fs	CSF3R_ENST00000418048.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000440588.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373104.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373106.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000361632.4_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000338937.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000331941.5_Frame_Shift_Ins_p.R469fs	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	469	Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634													31	636	---	---	---	---					
GRIK3	2899	broad.mit.edu	37	1	37291402	37291403	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:37291402_37291403insG	ENST00000373091.3	-	11	1571_1572	c.1555_1556insC	c.(1555-1557)gacfs	p.D519fs	GRIK3_ENST00000373093.4_Frame_Shift_Ins_p.D519fs	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	519					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GGTGATGGTCAGGGGGGCCACG	0.540													9	1555	---	---	---	---					
ZMYND12	84217	broad.mit.edu	37	1	42898878	42898879	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:42898878_42898879insG	ENST00000372565.3	-	7	1179_1180	c.910_911insC	c.(910-912)aaafs	p.K304fs	ZMYND12_ENST00000433602.2_Frame_Shift_Ins_p.K194fs|ZMYND12_ENST00000475426.1_5'UTR	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	304						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATGGTTTTTTGGGGGGCTTTG	0.411													9	312	---	---	---	---					
RNF220	55182	broad.mit.edu	37	1	44878032	44878033	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:44878032_44878033insC	ENST00000355387.2	+	2	713_714	c.263_264insC	c.(262-264)tccfs	p.S88fs	RNF220_ENST00000361799.2_Frame_Shift_Ins_p.S88fs|RNF220_ENST00000372247.2_Frame_Shift_Ins_p.S88fs			Q5VTB9	RN220_HUMAN	ring finger protein 220	88					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						AATCGTGATTTCCCCCCTTCTC	0.515													11	806	---	---	---	---					
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:55081756_55081757insG	ENST00000302250.2	-	3	511_512	c.351_352insC	c.(349-354)ccctatfs	p.Y118fs	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Frame_Shift_Ins_p.Y118fs	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	118						integral to membrane		p.T118fs*43(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTAGATAGTGGGGGGGTGTG	0.594													32	478	---	---	---	---					
CACHD1	57685	broad.mit.edu	37	1	65143921	65143922	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:65143921_65143922insC	ENST00000371073.2	+	23	3172_3173	c.3172_3173insC	c.(3172-3174)cccfs	p.P1058fs	CACHD1_ENST00000290039.5_Frame_Shift_Ins_p.P1007fs|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	1058					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ACCCTACTGTGCCCCCCAGAAA	0.485													9	199	---	---	---	---					
PTGFR	5737	broad.mit.edu	37	1	78958518	78958519	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:78958518_78958519insT	ENST00000370756.3	+	2	327_328	c.90_91insT	c.(88-93)gtttttfs	p.VF30fs	PTGFR_ENST00000370758.1_Frame_Shift_Ins_p.VF30fs|PTGFR_ENST00000370757.3_Frame_Shift_Ins_p.VF30fs	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	30					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GGCTTTCCGTATTTTTTTCAGT	0.450													17	1740	---	---	---	---					
CLCA2	9635	broad.mit.edu	37	1	86921042	86921043	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:86921042_86921043insC	ENST00000370565.4	+	14	2826_2827	c.2664_2665insC	c.(2662-2667)atccccfs	p.IP888fs		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	888					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CTCTGTTTATTCCCCCCAATTC	0.396													7	375	---	---	---	---					
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:89613321_89613322insC	ENST00000294671.2	-	8	1431_1432	c.1293_1294insG	c.(1291-1296)ggacaafs	p.Q432fs		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	432						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436													8	103	---	---	---	---					
LRRC8C	84230	broad.mit.edu	37	1	90179646	90179647	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:90179646_90179647insC	ENST00000370454.4	+	3	1772_1773	c.1517_1518insC	c.(1516-1518)cccfs	p.P506fs	RP11-302M6.4_ENST00000370453.5_Intron|LRRC8C_ENST00000479252.1_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	506						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		ATGAGGGAACTCCCCCCCTGGA	0.500													11	314	---	---	---	---					
EPHX4	253152	broad.mit.edu	37	1	92511121	92511122	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:92511121_92511122insG	ENST00000370383.4	+	4	606_607	c.508_509insG	c.(508-510)gggfs	p.G170fs		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	170						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TGGCCATGACTGGGGGGGCATG	0.386													55	754	---	---	---	---					
PPM1J	333926	broad.mit.edu	37	1	113253630	113253631	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:113253630_113253631insT	ENST00000464951.1	-	8	1899_1900	c.492_splice	c.e8+1	p.S164_splice	RP11-426L16.10_ENST00000471038.2_Intron|PPM1J_ENST00000359994.4_Splice_Site_p.S164_splice|PPM1J_ENST00000309276.6_Splice_Site_p.S370_splice|RP11-426L16.10_ENST00000606505.1_Splice_Site_p.L52_splice			Q5JR12	PPM1J_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1J	370	PP2C-like.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	14	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGAGTTTACCTTTTTGCCCTC	0.559													8	1803	---	---	---	---					
SLC16A1	6566	broad.mit.edu	37	1	113471889	113471890	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:113471889_113471890insG	ENST00000538576.1	-	2	872_873	c.41_42insC	c.(40-42)cgafs	p.R14fs	SLC16A1_ENST00000478835.1_5'UTR|SLC16A1_ENST00000369626.3_Frame_Shift_Ins_p.R14fs|SLC16A1_ENST00000433570.4_Frame_Shift_Ins_p.R14fs	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	14					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AGCCTCCATCTGGGGGGGTGTA	0.426													7	77	---	---	---	---					
SPAG17	200162	broad.mit.edu	37	1	118584454	118584455	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:118584454_118584455insG	ENST00000336338.5	-	21	3090_3091	c.3025_3026insC	c.(3025-3027)ccafs	p.P1009fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1009						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTCTGGTTGGTGGGGGGACTCT	0.371													8	517	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145584022	145584023	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:145584022_145584023insC	ENST00000393045.2	+	10	1343_1344	c.1253_1254insC	c.(1252-1254)tccfs	p.S418fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.S383fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	418					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCTGAGGTTTGCCCCCCGCCAG	0.500													20	906	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145585532	145585533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:145585532_145585533insG	ENST00000393045.2	+	14	1887_1888	c.1797_1798insG	c.(1795-1800)ccggggfs	p.PG599fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.PG564fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	599					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGGCCCCTGGGGGGGCCTT	0.663													10	105	---	---	---	---					
GJA5	2702	broad.mit.edu	37	1	147230551	147230552	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:147230551_147230552insG	ENST00000271348.2	-	2	956_957	c.795_796insC	c.(793-798)ccacttfs	p.L266fs	GJA5_ENST00000369237.1_Frame_Shift_Ins_p.L266fs	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	266					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane		p.P265P(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TGATTAAAGTCGGGGGGTGGTG	0.530													7	308	---	---	---	---					
TARS2	80222	broad.mit.edu	37	1	150477198	150477199	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:150477198_150477199insG	ENST00000369064.3	+	15	1843_1844	c.1809_1810insG	c.(1807-1812)tgggggfs	p.WG603fs	TARS2_ENST00000606933.1_Frame_Shift_Ins_p.WG521fs|TARS2_ENST00000369054.2_Frame_Shift_Ins_p.WG473fs	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	603					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity	p.C603C(2)|p.G604W(1)		cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CAGAAAGCTGCGGGGGGAAATG	0.569													7	444	---	---	---	---					
SETDB1	9869	broad.mit.edu	37	1	150917623	150917624	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:150917623_150917624insG	ENST00000368962.2	+	9	1305_1306	c.1179_1180insG	c.(1177-1182)ggggggfs	p.GG393fs	SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000271640.5_Intron|SETDB1_ENST00000368969.4_Intron	NM_001243491.1	NP_001230420.1	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	0	Tudor 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGAGGTTGGTGGGGGGGGAAC	0.475													10	91	---	---	---	---					
RFX5	5993	broad.mit.edu	37	1	151318740	151318741	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:151318740_151318741insG	ENST00000290524.4	-	3	234_235	c.56_57insC	c.(55-57)cggfs	p.R19fs	RFX5_ENST00000478564.1_5'UTR|RFX5_ENST00000452671.2_Frame_Shift_Ins_p.R19fs|RFX5_ENST00000452513.2_Frame_Shift_Ins_p.R19fs|RFX5_ENST00000368870.2_Frame_Shift_Ins_p.R19fs	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	19						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCACCACCTGGGGGGGCCCT	0.554													17	312	---	---	---	---					
SELENBP1	8991	broad.mit.edu	37	1	151338280	151338281	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:151338280_151338281insG	ENST00000435071.1	-	8	1155_1156	c.693_694insC	c.(691-696)ccagaafs	p.E232fs	SELENBP1_ENST00000368868.5_Frame_Shift_Ins_p.E296fs|SELENBP1_ENST00000447402.3_Frame_Shift_Ins_p.E234fs|SELENBP1_ENST00000426705.2_Frame_Shift_Ins_p.E338fs			Q13228	SBP1_HUMAN	selenium binding protein 1	296					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCACTTTCTTGGGGGGCACCT	0.545													7	294	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152279926	152279936	+	Frame_Shift_Del	DEL	TCGTAGTGGGA	TCGTAGTGGGA	-	rs77498426	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152279926_152279936delTCGTAGTGGGA	ENST00000368799.1	-	3	7461_7471	c.7426_7436delTCCCACTACGA	c.(7426-7437)gfs	p.SHYE2476fs	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2476	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACCAATTGCTCGTAGTGGGATCCCTGCCTT	0.573									Ichthyosis				11	387	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152281828	152281828	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152281828delT	ENST00000368799.1	-	3	5569	c.5534delA	c.(5533-5535)ccfs	p.H1845fs	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1845	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGACGTGGTGTGGCTGTGATG	0.542									Ichthyosis				33	513	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152282888	152282893	+	In_Frame_Del	DEL	GTCCAC	GTCCAC	-	rs143101193		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152282888_152282893delGTCCAC	ENST00000368799.1	-	3	4504_4509	c.4469_4474delGTGGAC	c.(4468-4476)cac>c	p.RGH1490del	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1490	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCCGGGTGTCCACGAATGGTGTC	0.583									Ichthyosis				14	631	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152283772	152283772	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152283772delT	ENST00000368799.1	-	3	3625	c.3590delA	c.(3589-3591)ccfs	p.H1197fs	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1197	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATGTGGTGTGGCTGTGATG	0.562									Ichthyosis				33	502	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152283860	152283865	+	In_Frame_Del	DEL	GTGCAC	GTGCAC	-	rs58001094	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152283860_152283865delGTGCAC	ENST00000368799.1	-	3	3532_3537	c.3497_3502delGTGCAC	c.(3496-3504)cac>c	p.RAH1166del	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1166	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCCGGGTGTGCACGAATGGTGTC	0.602									Ichthyosis				11	575	---	---	---	---					
KPRP	448834	broad.mit.edu	37	1	152732677	152732678	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:152732677_152732678insC	ENST00000368773.1	+	2	671_672	c.613_614insC	c.(613-615)cccfs	p.P205fs	KPRP_ENST00000606109.1_Frame_Shift_Ins_p.P205fs	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	205	Gln-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAACAACTACACCCCCCAGTTC	0.574													8	406	---	---	---	---					
PGLYRP4	57115	broad.mit.edu	37	1	153317810	153317811	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:153317810_153317811insC	ENST00000368739.3	-	4	533_534	c.175_176insG	c.(175-177)agafs	p.R59fs	PGLYRP4_ENST00000490266.1_5'UTR|PGLYRP4_ENST00000359650.5_Frame_Shift_Ins_p.R63fs			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	63					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACAGCTTCTGCCCCCCATGCC	0.589													9	650	---	---	---	---					
HAX1	10456	broad.mit.edu	37	1	154246356	154246357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:154246356_154246357insG	ENST00000328703.7	+	3	636_637	c.423_424insG	c.(421-426)ttggggfs	p.LG141fs	HAX1_ENST00000532105.1_Frame_Shift_Ins_p.LG13fs|HAX1_ENST00000483970.2_Frame_Shift_Ins_p.LG149fs|HAX1_ENST00000457918.2_Frame_Shift_Ins_p.LG93fs	NM_006118.3	NP_006109.2	O00165	HAX1_HUMAN	HCLS1 associated protein X-1	141	Involved in HCLS1 binding.		F -> L (in SCN3; mild form).			actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	15	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCAGGATCTTTGGGGGGGTCTT	0.554									Kostmann syndrome				19	299	---	---	---	---					
BCAN	63827	broad.mit.edu	37	1	156628493	156628494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:156628493_156628494insC	ENST00000329117.4	+	13	2932_2933	c.2596_2597insC	c.(2596-2598)cccfs	p.P866fs	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000496038.1_3'UTR	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	866	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCGTTGGGAGGCCCCCCAGATC	0.604													8	273	---	---	---	---					
MRPL24	79590	broad.mit.edu	37	1	156708444	156708445	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:156708444_156708445insG	ENST00000368211.4	-	2	190_191	c.52_53insC	c.(52-54)ttafs	p.L18fs	MRPL24_ENST00000361531.2_Frame_Shift_Ins_p.L18fs	NM_024540.3|NM_145729.2	NP_078816.2|NP_663781.1	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	18					translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATAGCGGTAATGGGGGGGCAGA	0.574													17	302	---	---	---	---					
IGSF9	57549	broad.mit.edu	37	1	159904586	159904587	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:159904586_159904587insG	ENST00000368094.1	-	7	896_897	c.699_700insC	c.(697-702)ccagaafs	p.E234fs	IGSF9_ENST00000361509.3_Frame_Shift_Ins_p.E234fs	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	234	Ig-like 3.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTGTTCTTGGGGGGCACCA	0.569													11	464	---	---	---	---					
VANGL2	57216	broad.mit.edu	37	1	160388801	160388802	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:160388801_160388802insG	ENST00000368061.2	+	4	676_677	c.202_203insG	c.(202-204)gggfs	p.G68fs		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	68					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane		p.E70fs*17(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGATGACAACTGGGGGGAAACG	0.554													13	526	---	---	---	---					
PVRL4	81607	broad.mit.edu	37	1	161059028	161059030	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:161059028_161059030delAGC	ENST00000368012.3	-	1	359_361	c.57_59delGCT	c.(55-60)cta>ct	p.LL21del		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	21					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCCAGCAGTAGCAGCAGCAGCA	0.567													8	557	---	---	---	---					
B4GALT3	8703	broad.mit.edu	37	1	161145761	161145762	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:161145761_161145762insC	ENST00000319769.5	-	3	311_312	c.89_90insG	c.(88-90)gttfs	p.V30fs	PPOX_ENST00000495483.1_Intron|B4GALT3_ENST00000367998.1_Frame_Shift_Ins_p.V30fs|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|B4GALT3_ENST00000470882.1_5'UTR	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	30					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	GACTTCGGAAGCCCCCCAGTGA	0.599													11	519	---	---	---	---					
DDR2	4921	broad.mit.edu	37	1	162745595	162745596	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:162745595_162745596insC	ENST00000367922.2	+	16	2448_2449	c.2010_2011insC	c.(2008-2013)gaccccfs	p.DP670fs	DDR2_ENST00000367921.3_Frame_Shift_Ins_p.DP670fs	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	670	Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CCCGCCACGAGCCCCCTAATTC	0.470													7	492	---	---	---	---					
RCSD1	92241	broad.mit.edu	37	1	167654710	167654711	+	Frame_Shift_Ins	INS	-	-	C	rs144007158	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:167654710_167654711insC	ENST00000367854.3	+	3	492_493	c.161_162insC	c.(160-162)tccfs	p.S54fs	RCSD1_ENST00000537350.1_Intron	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	54										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CTCCCCCTGTTCCCCCCCAAGG	0.554													8	256	---	---	---	---					
FMO1	2326	broad.mit.edu	37	1	171227337	171227338	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:171227337_171227338insG	ENST00000354841.4	+	1	242_243	c.111_112insG	c.(109-114)ctggggfs	p.LG37fs	FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Frame_Shift_Ins_p.LG37fs|FMO1_ENST00000402921.2_Frame_Shift_Ins_p.LG37fs			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	37					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCGATGACCTTGGGGGGCTGTG	0.530													17	873	---	---	---	---					
PAPPA2	60676	broad.mit.edu	37	1	176563963	176563964	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:176563963_176563964insG	ENST00000367662.3	+	3	2387_2388	c.1223_1224insG	c.(1222-1224)cggfs	p.R408fs	PAPPA2_ENST00000367661.3_Frame_Shift_Ins_p.R408fs	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	408					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.L408fs*49(2)|p.L408L(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCTTTGCTCCTGGGGGGAGACA	0.574													15	506	---	---	---	---					
CACNA1E	777	broad.mit.edu	37	1	181549749	181549750	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:181549749_181549750insC	ENST00000526775.1	+	6	953_954	c.788_789insC	c.(787-789)gccfs	p.A263fs	CACNA1E_ENST00000367570.1_Frame_Shift_Ins_p.A263fs|CACNA1E_ENST00000367573.2_Frame_Shift_Ins_p.A263fs|CACNA1E_ENST00000357570.5_Frame_Shift_Ins_p.A214fs|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Frame_Shift_Ins_p.A214fs|CACNA1E_ENST00000360108.3_Frame_Shift_Ins_p.A263fs	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	263					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAAGGATTTGACCCCCCTCACC	0.505													13	1457	---	---	---	---					
RNASEL	6041	broad.mit.edu	37	1	182554908	182554909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:182554908_182554909insC	ENST00000367559.3	-	2	1286_1287	c.1033_1034insG	c.(1033-1035)agcfs	p.S345fs	RNASEL_ENST00000444138.1_Frame_Shift_Ins_p.S345fs|RNASEL_ENST00000539397.1_Frame_Shift_Ins_p.S345fs	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	345					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						CTTCAGGGCTGCCCCCCAGTGT	0.455													8	255	---	---	---	---					
FAM129A	116496	broad.mit.edu	37	1	184764537	184764538	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:184764537_184764538insC	ENST00000367511.3	-	14	2553_2554	c.2360_2361insG	c.(2359-2361)gttfs	p.V787fs	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	787	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						CCTCTGGAAATCCCCCCAACTC	0.668													11	425	---	---	---	---					
KIF21B	23046	broad.mit.edu	37	1	200956270	200956271	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:200956270_200956271insG	ENST00000332129.2	-	25	3783_3784	c.3467_3468insC	c.(3466-3468)cctfs	p.P1156fs	KIF21B_ENST00000422435.2_Frame_Shift_Ins_p.P1156fs|KIF21B_ENST00000360529.5_Frame_Shift_Ins_p.P1156fs|KIF21B_ENST00000461742.2_Frame_Shift_Ins_p.P1156fs	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1156					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGATATCCAGTGGGGGGCCCAG	0.559													19	1137	---	---	---	---					
CACNA1S	779	broad.mit.edu	37	1	201046125	201046126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:201046125_201046126insC	ENST00000362061.3	-	12	1975_1976	c.1749_1750insG	c.(1747-1752)ggggtafs	p.V584fs	CACNA1S_ENST00000367338.3_Frame_Shift_Ins_p.V584fs	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	584					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTCATACCTCCCCCCAAAGA	0.574													18	666	---	---	---	---					
NAV1	89796	broad.mit.edu	37	1	201779175	201779176	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:201779175_201779176insC	ENST00000367296.4	+	23	4923_4924	c.4503_4504insC	c.(4501-4506)gaccccfs	p.DP1501fs	NAV1_ENST00000367300.3_Frame_Shift_Ins_p.DP1441fs|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367297.4_Frame_Shift_Ins_p.DP1493fs|NAV1_ENST00000367295.1_Frame_Shift_Ins_p.DP1107fs|NAV1_ENST00000367302.1_Frame_Shift_Ins_p.DP1454fs|NAV1_ENST00000295624.6_Frame_Shift_Ins_p.DP1498fs	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1501					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						TGGATGCAGAGCCCCCCGAGAT	0.525													14	506	---	---	---	---					
KLHL12	59349	broad.mit.edu	37	1	202862507	202862508	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:202862507_202862508insC	ENST00000367261.3	-	11	1657_1658	c.1439_1440insG	c.(1438-1440)gttfs	p.V480fs	KLHL12_ENST00000367259.1_Intron|KLHL12_ENST00000435533.3_Frame_Shift_Ins_p.V518fs	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	480	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			TACCATCAAATCCCCCCACCAC	0.455													7	846	---	---	---	---					
FMOD	2331	broad.mit.edu	37	1	203316599	203316600	+	Frame_Shift_Ins	INS	-	-	C	rs139730140	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:203316599_203316600insC	ENST00000354955.4	-	2	1262_1263	c.799_800insG	c.(799-801)gccfs	p.A267fs	FMOD_ENST00000464898.1_5'UTR	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	267					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			CAGCTTGGGCGCCCCCCGGAAG	0.579													9	239	---	---	---	---					
ATP2B4	493	broad.mit.edu	37	1	203668728	203668729	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:203668728_203668729insG	ENST00000357681.5	+	4	1655_1656	c.532_533insG	c.(532-534)gggfs	p.G178fs	ATP2B4_ENST00000341360.2_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000367219.3_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000391954.2_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000367218.3_Frame_Shift_Ins_p.G178fs	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	178					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAGCAATTCCGGGGGCTGCAG	0.510													9	908	---	---	---	---					
PIK3C2B	5287	broad.mit.edu	37	1	204438071	204438072	+	Frame_Shift_Ins	INS	-	-	G	rs115574296	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:204438071_204438072insG	ENST00000367187.3	-	3	1415_1416	c.859_860insC	c.(859-861)cacfs	p.H287fs	PIK3C2B_ENST00000424712.2_Frame_Shift_Ins_p.H287fs	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	287	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding	p.R287fs*92(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGCATAGGTGCGGGGGGGCACC	0.624													22	178	---	---	---	---					
NFASC	23114	broad.mit.edu	37	1	204924032	204924033	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:204924032_204924033insC	ENST00000367172.4	+	7	816_817	c.488_489insC	c.(487-489)accfs	p.T163fs	NFASC_ENST00000367171.4_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000360049.4_Frame_Shift_Ins_p.T157fs|NFASC_ENST00000401399.1_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000539706.1_Frame_Shift_Ins_p.T157fs|NFASC_ENST00000367170.4_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000338586.6_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000404907.1_Frame_Shift_Ins_p.T157fs|NFASC_ENST00000513543.1_Frame_Shift_Ins_p.T157fs|NFASC_ENST00000339876.6_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000367169.4_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000338515.6_Frame_Shift_Ins_p.T163fs|NFASC_ENST00000404076.1_Frame_Shift_Ins_p.T157fs|NFASC_ENST00000403080.1_Frame_Shift_Ins_p.T163fs			O94856	NFASC_HUMAN	neurofascin	163	Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.P159fs*12(1)|p.P165fs*12(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTCCAGTGCAACCCCCCGCCTG	0.559													9	745	---	---	---	---					
TMEM81	388730	broad.mit.edu	37	1	205052693	205052694	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:205052693_205052694insC	ENST00000367167.3	-	1	951_952	c.755_756insG	c.(754-756)gctfs	p.A252fs		NM_203376.1	NP_976310.1	Q6P7N7	TMM81_HUMAN	transmembrane protein 81	252						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ACTGCTGCAGGCCCCCCCTTAG	0.540													11	207	---	---	---	---					
CR2	1380	broad.mit.edu	37	1	207642043	207642044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:207642043_207642044insC	ENST00000367057.3	+	3	806_807	c.617_618insC	c.(616-618)gccfs	p.A206fs	CR2_ENST00000367058.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000367059.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000458541.2_Frame_Shift_Ins_p.A206fs|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	206	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity	p.T209fs*10(1)		NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGGAGTGCTGTCCCCCCCACAT	0.396													23	480	---	---	---	---					
LAMB3	3914	broad.mit.edu	37	1	209807794	209807795	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:209807794_209807795insC	ENST00000391911.1	-	5	950_951	c.561_562insG	c.(559-564)ggaggtfs	p.G188fs	LAMB3_ENST00000356082.4_Frame_Shift_Ins_p.G188fs|LAMB3_ENST00000367030.3_Frame_Shift_Ins_p.G188fs	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	188	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTACCTACCTTCCCCCCATTTA	0.599													8	372	---	---	---	---					
DIEXF	27042	broad.mit.edu	37	1	210014266	210014267	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:210014266_210014267insC	ENST00000491415.2	+	8	1408_1409	c.1351_1352insC	c.(1351-1353)cccfs	p.P451fs		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	451					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						CCTCATTGCTTCCCCCCTGGGC	0.465													8	393	---	---	---	---					
SUSD4	55061	broad.mit.edu	37	1	223395558	223395559	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:223395558_223395559insC	ENST00000343846.3	-	8	2081_2082	c.1448_1449insG	c.(1447-1449)accfs	p.T483fs	SUSD4_ENST00000366878.4_Frame_Shift_Ins_p.T483fs|SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_Frame_Shift_Ins_p.T323fs			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	483						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CCATTAGAGGAATCTCTGTAAA	0.406													64	599	---	---	---	---					
PGBD5	79605	broad.mit.edu	37	1	230493044	230493045	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr1:230493044_230493045insG	ENST00000321327.2	-	4	443_444	c.444_445insC	c.(442-447)ccgcgcfs	p.R149fs	PGBD5_ENST00000391860.1_Frame_Shift_Ins_p.R4fs|PGBD5_ENST00000525115.1_Frame_Shift_Ins_p.R50fs			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	50						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GCACTGGCGCTGGGGGGCATCT	0.569													7	481	---	---	---	---					
KCNS3	3790	broad.mit.edu	37	2	18112337	18112338	+	Frame_Shift_Ins	INS	-	-	G	rs35579067		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:18112337_18112338insG	ENST00000403915.1	+	3	513_514	c.62_63insG	c.(61-63)gggfs	p.G21fs	KCNS3_ENST00000304101.4_Frame_Shift_Ins_p.G21fs|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	21					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AACCTGAATGTGGGGGGCTTTA	0.535													8	879	---	---	---	---					
DNMT3A	1788	broad.mit.edu	37	2	25523008	25523009	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:25523008_25523009insG	ENST00000264709.3	-	3	513_514	c.177_splice	c.e3+1	p.R59_splice	DNMT3A_ENST00000321117.5_Splice_Site_p.R59_splice|DNMT3A_ENST00000406659.3_Splice_Site_p.R59_splice	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	59					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACACTCACCGGGGGGTGCTT	0.649			"""Mis, F, N, S"""		AML								15	354	---	---	---	---					
CAD	790	broad.mit.edu	37	2	27456981	27456982	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:27456981_27456982insC	ENST00000264705.4	+	22	3667_3668	c.3505_3506insC	c.(3505-3507)cccfs	p.P1169fs	CAD_ENST00000403525.1_Frame_Shift_Ins_p.P1106fs	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1169	ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GACGCTGGTGACCCCCCCACAA	0.574													7	197	---	---	---	---					
SLC30A3	7781	broad.mit.edu	37	2	27479379	27479380	+	Frame_Shift_Ins	INS	-	-	G	rs146572471	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:27479379_27479380insG	ENST00000233535.4	-	7	1244_1245	c.892_893insC	c.(892-894)caafs	p.Q298fs	SLC30A3_ENST00000447008.2_Frame_Shift_Ins_p.Q293fs	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	298					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity	p.R298H(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCACATTGCGGGGGGTACCT	0.604													12	978	---	---	---	---					
NRBP1	29959	broad.mit.edu	37	2	27658017	27658018	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:27658017_27658018insC	ENST00000233557.3	+	8	1416_1417	c.584_585insC	c.(583-585)gccfs	p.A195fs	NRBP1_ENST00000379852.3_Frame_Shift_Ins_p.A195fs|NRBP1_ENST00000379863.3_Frame_Shift_Ins_p.A195fs			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	195	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					CACTCCTGTGACCCCCCCATCA	0.589													9	339	---	---	---	---					
XDH	7498	broad.mit.edu	37	2	31598344	31598345	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:31598344_31598345delCA	ENST00000379416.3	-	15	1551_1552	c.1503_1504delTG	c.(1501-1506)ccgtfs	p.PG501fs		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	501					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ACCATGCCACCAGGGGCATCGG	0.604													17	110	---	---	---	---					
MSH6	2956	broad.mit.edu	37	2	48030796	48030797	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:48030796_48030797insG	ENST00000234420.4	+	5	3562_3563	c.3410_3411insG	c.(3409-3411)aggfs	p.R1137fs	MSH6_ENST00000538136.1_Frame_Shift_Ins_p.R835fs|MSH6_ENST00000540021.1_Frame_Shift_Ins_p.R1007fs|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	1137					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGACCAAATATGGGGGGCAAGT	0.376			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				8	1093	---	---	---	---					
PSME4	23198	broad.mit.edu	37	2	54167139	54167140	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:54167139_54167140insG	ENST00000404125.1	-	4	556		c.e4-2		PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding	p.?(1)		breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCTACAGAACTGGGGGGGGAAA	0.347													7	64	---	---	---	---					
B3GNT2	10678	broad.mit.edu	37	2	62449597	62449598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:62449597_62449598insG	ENST00000301998.4	+	2	494_495	c.242_243insG	c.(241-243)aggfs	p.R81fs	B3GNT2_ENST00000405767.1_Frame_Shift_Ins_p.R81fs	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	81						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	p.T81T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			ACCAACCAGACGGGGGAGGCGG	0.554													7	2316	---	---	---	---					
PLEK	5341	broad.mit.edu	37	2	68622886	68622887	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:68622886_68622887insC	ENST00000234313.7	+	9	1170_1171	c.991_992insC	c.(991-993)cccfs	p.P331fs		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	331	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GCAAGCAGCCACCCCCAAGGAG	0.540													8	740	---	---	---	---					
ANTXR1	84168	broad.mit.edu	37	2	69409763	69409764	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:69409763_69409764insC	ENST00000303714.4	+	16	1646_1647	c.1324_1325insC	c.(1324-1326)cccfs	p.P442fs		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	442					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCGGCCTTCTTCCCCCCGGAAG	0.421									Familial Infantile Hemangioma				7	373	---	---	---	---					
NAT8	9027	broad.mit.edu	37	2	73868515	73868516	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:73868515_73868516insT	ENST00000272425.3	-	2	389_390	c.240_241insA	c.(238-243)aacctgfs	p.NL80fs		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	80	N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						TCCGTCCAGGGTTTTTTGGCAA	0.564													16	1432	---	---	---	---					
NAT8	9027	broad.mit.edu	37	2	73868608	73868609	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:73868608_73868609insC	ENST00000272425.3	-	2	296_297	c.147_148insG	c.(145-150)ggccctfs	p.GP49fs		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	49					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						AGGGCGAGGGGCCCCCCAAGTA	0.614													8	593	---	---	---	---					
SLC4A5	57835	broad.mit.edu	37	2	74480126	74480127	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:74480126_74480127insG	ENST00000394019.2	-	15	1639_1640	c.1242_1243insC	c.(1240-1245)ccagaafs	p.E415fs	SLC4A5_ENST00000346834.4_Frame_Shift_Ins_p.E415fs|SLC4A5_ENST00000423644.1_Frame_Shift_Ins_p.E415fs|SLC4A5_ENST00000377632.1_Frame_Shift_Ins_p.E415fs|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377634.4_Frame_Shift_Ins_p.E415fs|SLC4A5_ENST00000359484.4_Frame_Shift_Ins_p.E351fs|SLC4A5_ENST00000358683.4_Frame_Shift_Ins_p.E351fs|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000357822.5_Frame_Shift_Ins_p.E415fs	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	415						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGCACCTTCTTGGGGGGCTCAA	0.475													8	278	---	---	---	---					
DCTN1	1639	broad.mit.edu	37	2	74593376	74593377	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:74593376_74593377insG	ENST00000361874.3	-	23	3071_3072	c.2754_2755insC	c.(2752-2757)ccgcaafs	p.Q919fs	DCTN1_ENST00000409868.1_Frame_Shift_Ins_p.Q902fs|DCTN1_ENST00000409240.1_Frame_Shift_Ins_p.Q882fs|DCTN1_ENST00000409567.3_Frame_Shift_Ins_p.Q899fs|DCTN1_ENST00000409438.1_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000394003.3_Frame_Shift_Ins_p.Q912fs|DCTN1_ENST00000407639.2_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000495643.1_5'UTR	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	919					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						CCTACCTTGCTGGGGGGCCGCT	0.559													7	621	---	---	---	---					
MOGS	7841	broad.mit.edu	37	2	74690034	74690035	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:74690034_74690035insG	ENST00000233616.4	-	4	1043_1044	c.881_882insC	c.(880-882)cgafs	p.R294fs	MOGS_ENST00000409065.1_3'UTR|MOGS_ENST00000535045.1_3'UTR|MOGS_ENST00000462443.1_5'UTR|MOGS_ENST00000452063.2_Frame_Shift_Ins_p.R188fs	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	294					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						GGTAGCGTTCAGGGGGGGCCCC	0.584													7	389	---	---	---	---					
PCGF1	84759	broad.mit.edu	37	2	74732899	74732900	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:74732899_74732900insG	ENST00000233630.6	-	6	1442		c.e6-2		PCGF1_ENST00000480844.2_Splice_Site	NM_032673.2	NP_116062.2	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1						histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(2)	12						TTGCCAGAACTGGGGGGAAATA	0.530													16	1005	---	---	---	---					
SEMA4F	10505	broad.mit.edu	37	2	74906845	74906846	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:74906845_74906846insC	ENST00000357877.2	+	14	1971_1972	c.1822_1823insC	c.(1822-1824)cccfs	p.P608fs	SEMA4F_ENST00000473350.1_3'UTR|SEMA4F_ENST00000339773.5_Frame_Shift_Ins_p.P453fs	NM_004263.3	NP_004254.2	O95754	SEM4F_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	608	Ig-like C2-type.				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			biliary_tract(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	45						GACTGCACTCACCCCCCGGCGG	0.629													26	570	---	---	---	---					
HK2	3099	broad.mit.edu	37	2	75104377	75104378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:75104377_75104378insG	ENST00000290573.2	+	8	1560_1561	c.960_961insG	c.(958-963)ttggggfs	p.LG320fs	HK2_ENST00000409174.1_Frame_Shift_Ins_p.LG292fs	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	320	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						AGCTGCTCTTTGGGGGGAAGCT	0.545													29	1510	---	---	---	---					
TCF7L1	83439	broad.mit.edu	37	2	85536195	85536196	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:85536195_85536196insC	ENST00000282111.3	+	12	1652_1653	c.1377_1378insC	c.(1375-1380)ctccccfs	p.LP459fs		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	459					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						TTCAGTACCTGCCCCCCGAGAA	0.614													11	290	---	---	---	---					
USP39	10713	broad.mit.edu	37	2	85863227	85863228	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:85863227_85863228insG	ENST00000323701.6	+	7	1011_1012	c.1001_1002insG	c.(1000-1002)cggfs	p.R334fs	USP39_ENST00000409025.1_Frame_Shift_Ins_p.R334fs|USP39_ENST00000409470.1_Frame_Shift_Ins_p.R334fs|USP39_ENST00000409766.3_Frame_Shift_Ins_p.R334fs|USP39_ENST00000459775.1_3'UTR|USP39_ENST00000450066.2_Frame_Shift_Ins_p.R231fs	NM_006590.3	NP_006581.2	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	334					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						CACTCAGCTCTGGGGGGCACAA	0.416													7	457	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	6	---	---	---	---					
ANKRD23	200539	broad.mit.edu	37	2	97507820	97507821	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:97507820_97507821insG	ENST00000318357.4	-	3	317_318	c.276_277insC	c.(274-279)ccggaafs	p.E93fs	ANKRD23_ENST00000476975.1_5'UTR|ANKRD23_ENST00000331001.2_Frame_Shift_Ins_p.E93fs|ANKRD23_ENST00000418232.1_Frame_Shift_Ins_p.E93fs	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	93						nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						TCAGGTTTCCTGGGGGGGACTC	0.530													7	230	---	---	---	---					
MFSD9	84804	broad.mit.edu	37	2	103334977	103334978	+	Frame_Shift_Ins	INS	-	-	G	rs145424077		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:103334977_103334978insG	ENST00000258436.5	-	6	1369_1370	c.1326_1327insC	c.(1324-1329)ccgcctfs	p.P443fs		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	443					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						GCGCCCAGGCTGGGGGGGCCGC	0.554													9	84	---	---	---	---					
EDAR	10913	broad.mit.edu	37	2	109539836	109539837	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:109539836_109539837insG	ENST00000409271.1	-	6	872_873	c.429_430insC	c.(427-432)ccacacfs	p.H144fs	EDAR_ENST00000258443.2_Frame_Shift_Ins_p.H144fs|EDAR_ENST00000376651.1_Frame_Shift_Ins_p.H144fs			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	144					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TCCTTGGTGTTGGGGGGTGCCA	0.535													12	436	---	---	---	---					
WDR33	55339	broad.mit.edu	37	2	128467384	128467385	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:128467384_128467385insG	ENST00000322313.4	-	19	3512_3513	c.3354_3355insC	c.(3352-3357)ccgaggfs	p.R1119fs		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1119					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCCCTTCCTCTGGGGGGAGCAC	0.545													8	1102	---	---	---	---					
MAP3K19	80122	broad.mit.edu	37	2	135740765	135740766	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:135740765_135740766insC	ENST00000392915.1	-	9	3528_3529	c.3409_3410insG	c.(3409-3411)gggfs	p.G1137fs	MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000375845.3_Intron|MAP3K19_ENST00000358371.4_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000375844.3_Intron					mitogen-activated protein kinase kinase kinase 19																		ttcatcgcccaccccCCAAGAT	0.376													9	270	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:168099957_168099958insG	ENST00000409195.1	+	9	2144_2145	c.2055_2056insG	c.(2053-2058)acggggfs	p.TG685fs	XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.TG685fs|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.TG463fs|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	510					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGACATAACTGGGGGGGATGT	0.421													12	241	---	---	---	---					
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:171240258_171240259insC	ENST00000334231.6	+	12	1251_1252	c.1251_1252insC	c.(1249-1254)aaccccfs	p.NP417fs	MYO3B_ENST00000409044.3_Frame_Shift_Ins_p.NP408fs|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Frame_Shift_Ins_p.NP408fs			Q8WXR4	MYO3B_HUMAN	myosin IIIB	408	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCGCCTCCAATCCCCCCCACAT	0.465													16	363	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179398169	179398170	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:179398169_179398170insG	ENST00000589042.1	-	358	103396_103397	c.103172_103173insC	c.(103171-103173)cccfs	p.P34391fs	TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000359218.5_Frame_Shift_Ins_p.P25451fs|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000342992.6_Frame_Shift_Ins_p.P31823fs|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000342175.6_Frame_Shift_Ins_p.P25518fs|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Frame_Shift_Ins_p.P25326fs|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Frame_Shift_Ins_p.P32750fs	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32750							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATGTTGGTGGGGGGATGCC	0.460													10	391	---	---	---	---					
NEUROD1	4760	broad.mit.edu	37	2	182542971	182542972	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:182542971_182542972insG	ENST00000295108.3	-	2	1073_1074	c.616_617insC	c.(616-618)cctfs	p.P206fs	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	206					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CGTCGGCAGGTGGGGGGGCATG	0.619													28	594	---	---	---	---					
ITGAV	3685	broad.mit.edu	37	2	187521084	187521085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:187521084_187521085insG	ENST00000261023.3	+	17	1949_1950	c.1675_1676insG	c.(1675-1677)gggfs	p.G559fs	ITGAV_ENST00000433736.2_Frame_Shift_Ins_p.G513fs|ITGAV_ENST00000374907.3_Frame_Shift_Ins_p.G523fs|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	559					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GACTATTTCAAGGGGGGGACTG	0.431													16	415	---	---	---	---					
HECW2	57520	broad.mit.edu	37	2	197171262	197171263	+	Frame_Shift_Ins	INS	-	-	G	rs144884935	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:197171262_197171263insG	ENST00000260983.2	-	13	2945_2946	c.2763_2764insC	c.(2761-2766)cctgaafs	p.E922fs	HECW2_ENST00000409111.1_Frame_Shift_Ins_p.E566fs	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	922	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AGGAACTTCACGGGGGGAGACT	0.530													10	574	---	---	---	---					
ALS2	57679	broad.mit.edu	37	2	202588159	202588160	+	Frame_Shift_Ins	INS	-	-	C	rs41309046		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:202588159_202588160insC	ENST00000264276.6	-	22	3889_3890	c.3517_3518insG	c.(3517-3519)aaafs	p.K1173fs	ALS2_ENST00000457679.2_Frame_Shift_Ins_p.K485fs	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	1173					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CATATACTTTTCCCCCCTGCAC	0.406													8	431	---	---	---	---					
GPR1	2825	broad.mit.edu	37	2	207041591	207041592	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:207041591_207041592insA	ENST00000407325.2	-	3	742_743	c.380_381insT	c.(379-381)tctfs	p.S127fs	GPR1_ENST00000437420.1_Frame_Shift_Ins_p.S127fs	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	127						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		TCACTGTCAGGAAAAAAACACT	0.455													10	404	---	---	---	---					
RNF25	64320	broad.mit.edu	37	2	219529513	219529514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:219529513_219529514insC	ENST00000295704.2	-	9	1189_1190	c.749_750insG	c.(748-750)gatfs	p.D250fs		NM_022453.2	NP_071898.2	Q96BH1	RNF25_HUMAN	ring finger protein 25	250					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding	p.I251fs*3(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCAATGATTCCCCCCCGCTC	0.564													9	308	---	---	---	---					
CCDC108	255101	broad.mit.edu	37	2	219883882	219883883	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:219883882_219883883insG	ENST00000341552.5	-	21	3575_3576	c.3492_3493insC	c.(3490-3495)cctcctfs	p.P1165fs	CCDC108_ENST00000453220.1_Frame_Shift_Ins_p.P1165fs|CCDC108_ENST00000441968.1_Frame_Shift_Ins_p.P1165fs	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1165						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGTGAGGACGGGGGGGATCT	0.614													7	92	---	---	---	---					
NYAP2	57624	broad.mit.edu	37	2	226447071	226447072	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:226447071_226447072insC	ENST00000272907.6	+	4	1351_1352	c.938_939insC	c.(937-939)tccfs	p.S313fs	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	313	Pro-rich.																TCAGTGCCATGCCCCCCCAAGG	0.619													13	220	---	---	---	---					
ATG16L1	55054	broad.mit.edu	37	2	234171866	234171866	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:234171866delC	ENST00000392017.4	+	3	557	c.300delC	c.(298-300)cafs	p.H100fs	ATG16L1_ENST00000392020.4_Frame_Shift_Del_p.H100fs|ATG16L1_ENST00000373525.5_Intron|ATG16L1_ENST00000392018.1_Frame_Shift_Del_p.H100fs|ATG16L1_ENST00000347464.5_Intron	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	100					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		CTGAATTACACAAGAAACGTG	0.502													10	44	---	---	---	---					
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:240954220_240954221insG	ENST00000252711.2	-	5	704_705	c.604_605insC	c.(604-606)cctfs	p.P202fs	NDUFA10_ENST00000307300.4_Frame_Shift_Ins_p.P242fs|NDUFA10_ENST00000404554.1_Frame_Shift_Ins_p.P202fs	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535													21	370	---	---	---	---					
PPP1R7	5510	broad.mit.edu	37	2	242092998	242092999	+	Frame_Shift_Ins	INS	-	-	G	rs140300724		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr2:242092998_242092999insG	ENST00000234038.6	+	2	634_635	c.160_161insG	c.(160-162)gggfs	p.G54fs	PPP1R7_ENST00000406106.3_Frame_Shift_Ins_p.G54fs|PPP1R7_ENST00000404405.3_Frame_Shift_Ins_p.G54fs|PPP1R7_ENST00000402734.1_Intron|PPP1R7_ENST00000401987.1_Intron|PPP1R7_ENST00000407025.1_Frame_Shift_Ins_p.G54fs|PPP1R7_ENST00000272983.8_Intron	NM_002712.1	NP_002703.1	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	54						cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)	23		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		TGGGGAGGAGCGGGGGGAGGAG	0.629													8	424	---	---	---	---					
SRGAP3	9901	broad.mit.edu	37	3	9034599	9034600	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:9034599_9034600insC	ENST00000383836.3	-	20	2975_2976	c.2548_2549insG	c.(2548-2550)gatfs	p.D850fs	SRGAP3_ENST00000360413.3_Frame_Shift_Ins_p.D826fs	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	850					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCGGCCCATCACCCCCCCAAAG	0.554			T	RAF1	pilocytic astrocytoma								11	81	---	---	---	---					
VHL	7428	broad.mit.edu	37	3	10188268	10188269	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:10188268_10188269insC	ENST00000256474.2	+	2	1251_1252	c.411_412insC	c.(409-414)gtcatcfs	p.I138fs	VHL_ENST00000477538.1_3'UTR|VHL_ENST00000345392.2_Intron	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	138	Involved in binding to CCT complex.				anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.P138fs*1(2)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		AATTATTTGTGCCATCTCTCAA	0.421		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				78	139	---	---	---	---					
TATDN2	9797	broad.mit.edu	37	3	10312538	10312539	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:10312538_10312539insG	ENST00000287652.4	+	4	2723_2724	c.1672_1673insG	c.(1672-1674)gggfs	p.G558fs	RP11-438J1.1_ENST00000450534.1_3'UTR|TATDN2_ENST00000448281.2_Frame_Shift_Ins_p.G558fs	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	558						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						GGATCTGGTCTGGGGGGCCTTT	0.505													10	940	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14538073	14538073	+	RNA	DEL	A	A	-	rs11333211		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:14538073delA	ENST00000273083.3	-	0	2744							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						GGATGCCTGCAAGGAACACGG	0.607													8	146	---	---	---	---					
VILL	50853	broad.mit.edu	37	3	38043303	38043304	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:38043303_38043304insC	ENST00000283713.6	+	13	1697_1698	c.1431_1432insC	c.(1429-1434)gaccccfs	p.DP477fs	VILL_ENST00000465644.1_Frame_Shift_Ins_p.DP195fs|VILL_ENST00000383759.2_Frame_Shift_Ins_p.DP477fs			O15195	VILL_HUMAN	villin-like	477					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton	p.H480fs*38(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TGGGCAGCGAGCCCCCCCACTT	0.594													10	139	---	---	---	---					
TRAK1	22906	broad.mit.edu	37	3	42242449	42242450	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:42242449_42242450insC	ENST00000327628.5	+	12	1730_1731	c.1330_1331insC	c.(1330-1332)cccfs	p.P444fs	TRAK1_ENST00000396175.1_Frame_Shift_Ins_p.P386fs|TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000341421.3_Frame_Shift_Ins_p.P386fs|TRAK1_ENST00000449246.1_Frame_Shift_Ins_p.P370fs	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	444	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						CTGCGTCAGCACCCCCCGGTCC	0.594													7	540	---	---	---	---					
RBM6	10180	broad.mit.edu	37	3	50005144	50005145	+	Frame_Shift_Ins	INS	-	-	G	rs141234052		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:50005144_50005145insG	ENST00000266022.4	+	3	545_546	c.286_287insG	c.(286-288)gggfs	p.G96fs	RBM6_ENST00000539992.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000443081.1_5'UTR|RBM6_ENST00000422955.1_Intron	NM_005777.2	NP_005768.1	P78332	RBM6_HUMAN	RNA binding motif protein 6	96					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ACATGATTTCAGGGGGGGAGAT	0.495													11	142	---	---	---	---					
SFMBT1	51460	broad.mit.edu	37	3	52962211	52962212	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:52962211_52962212insG	ENST00000394752.3	-	9	1425_1426	c.1043_1044insC	c.(1042-1044)cccfs	p.P348fs	SFMBT1_ENST00000296295.6_Frame_Shift_Ins_p.P348fs|SFMBT1_ENST00000394750.1_Frame_Shift_Ins_p.P348fs|SFMBT1_ENST00000358080.2_Frame_Shift_Ins_p.P348fs	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	348					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GTGCACCTGGAGGGGGGCTGAT	0.530													8	474	---	---	---	---					
IL17RB	55540	broad.mit.edu	37	3	53898813	53898814	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:53898813_53898814insC	ENST00000288167.3	+	11	996_997	c.987_988insC	c.(985-990)ctccccfs	p.LP329fs		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	329					defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		CCACACTACTGCCCCCCATTAA	0.406													7	799	---	---	---	---					
KCTD6	200845	broad.mit.edu	37	3	58486771	58486772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:58486771_58486772insG	ENST00000355076.6	+	2	1109_1110	c.126_127insG	c.(124-129)ttggggfs	p.LG42fs	KCTD6_ENST00000404589.3_Frame_Shift_Ins_p.LG42fs|KCTD6_ENST00000490264.1_Frame_Shift_Ins_p.LG42fs|KCTD6_ENST00000479470.1_3'UTR	NM_153331.3	NP_699162.3	Q8NC69	KCTD6_HUMAN	potassium channel tetramerization domain containing 6	42	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		GAGCTATGTTTGGGGGGGACTT	0.465													10	194	---	---	---	---					
CADPS	8618	broad.mit.edu	37	3	62459994	62459995	+	Splice_Site	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:62459994_62459995insA	ENST00000383710.4	-	24	3679_3680	c.3329_splice	c.e24-1	p.Q1111_splice	CADPS_ENST00000357948.3_Splice_Site_p.Q1032_splice|CADPS_ENST00000283269.9_Splice_Site_p.Q1072_splice	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1111	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GCAATCCTGGTTCTATTAAAAC	0.396													24	144	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87018182	87018183	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:87018182_87018183insC	ENST00000398399.2	-	3	857_858	c.494_495insG	c.(493-495)ggtfs	p.G165fs	VGLL3_ENST00000383698.3_Frame_Shift_Ins_p.G165fs	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGGATGAACTCCCCCCAAACA	0.579													9	325	---	---	---	---					
CPOX	1371	broad.mit.edu	37	3	98304318	98304319	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:98304318_98304319insG	ENST00000264193.2	-	5	1356_1357	c.1138_1139insC	c.(1138-1140)ggafs	p.G380fs		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	380						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CAGCTTCTCCTGGGGGGTGAAT	0.500													10	565	---	---	---	---					
TAGLN3	29114	broad.mit.edu	37	3	111718404	111718405	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:111718404_111718405insC	ENST00000393917.2	+	2	687_688	c.135_136insC	c.(133-138)ccccccfs	p.PP45fs	TAGLN3_ENST00000455401.2_Frame_Shift_Ins_p.PP45fs|TAGLN3_ENST00000478951.1_Frame_Shift_Ins_p.PP45fs|TAGLN3_ENST00000273368.4_Frame_Shift_Ins_p.PP45fs	NM_013259.2	NP_037391.2	Q9UI15	TAGL3_HUMAN	transgelin 3	45	CH.				central nervous system development|muscle organ development					endometrium(2)|lung(5)|urinary_tract(1)	8						TAGAGCACCCGCCCCCCGGCAG	0.614													9	168	---	---	---	---					
IGSF11	152404	broad.mit.edu	37	3	118647520	118647521	+	Frame_Shift_Ins	INS	-	-	G	rs145433873	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:118647520_118647521insG	ENST00000354673.2	-	5	636_637	c.256_257insC	c.(256-258)gttfs	p.V86fs	IGSF11_ENST00000489689.1_Frame_Shift_Ins_p.V87fs|IGSF11_ENST00000491903.1_Frame_Shift_Ins_p.V87fs|IGSF11_ENST00000425327.2_Frame_Shift_Ins_p.V86fs|IGSF11_ENST00000393775.2_Frame_Shift_Ins_p.V87fs|IGSF11_ENST00000459718.1_5'UTR|IGSF11_ENST00000441144.2_Frame_Shift_Ins_p.V86fs	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	87	Ig-like V-type.				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						ACCGTGGAACCGGGGGGCACCA	0.465													8	208	---	---	---	---					
GPR156	165829	broad.mit.edu	37	3	119885959	119885960	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:119885959_119885960insC	ENST00000464295.1	-	10	2809_2810	c.2364_2365insG	c.(2362-2367)ggtggcfs	p.G789fs	GPR156_ENST00000461057.1_Frame_Shift_Ins_p.G785fs|GPR156_ENST00000315843.3_Frame_Shift_Ins_p.G789fs			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	789						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		CAGGAAGCCAGCCCCCCAGTAG	0.550													13	553	---	---	---	---					
GPR156	165829	broad.mit.edu	37	3	119900210	119900211	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:119900210_119900211insG	ENST00000464295.1	-	8	1142		c.e8-2		GPR156_ENST00000461057.1_Splice_Site|GPR156_ENST00000315843.3_Splice_Site			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156							integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GAGCAGACCCTGGGGGGTGAAG	0.515													7	262	---	---	---	---					
MYLK	4638	broad.mit.edu	37	3	123368043	123368044	+	Splice_Site	INS	-	-	G	rs138786404		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:123368043_123368044insG	ENST00000360772.3	-	26	4667		c.e26-2		MYLK_ENST00000360304.3_Splice_Site|MYLK_ENST00000359169.1_Splice_Site|MYLK_ENST00000354792.5_Splice_Site|MYLK_ENST00000346322.5_Splice_Site|MYLK_ENST00000475616.1_Splice_Site			Q15746	MYLK_HUMAN	myosin light chain kinase						aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTTCGGCTCTGGGGGGGGCAC	0.624													10	109	---	---	---	---					
ZXDC	79364	broad.mit.edu	37	3	126180565	126180566	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:126180565_126180566insG	ENST00000389709.3	-	6	1992_1993	c.1939_1940insC	c.(1939-1941)agafs	p.R647fs	ZXDC_ENST00000336332.5_Frame_Shift_Ins_p.R647fs	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	647	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		GGCATTTTCTCGGGGGGTGCTC	0.579													7	407	---	---	---	---					
IFT122	55764	broad.mit.edu	37	3	129183576	129183577	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:129183576_129183577insG	ENST00000296266.3	+	8	860_861	c.668_669insG	c.(667-669)cggfs	p.R223fs	IFT122_ENST00000440957.2_Frame_Shift_Ins_p.R22fs|IFT122_ENST00000349441.2_Frame_Shift_Ins_p.R120fs|IFT122_ENST00000348417.2_Frame_Shift_Ins_p.R172fs|IFT122_ENST00000347300.2_Frame_Shift_Ins_p.R172fs|IFT122_ENST00000507564.1_Frame_Shift_Ins_p.R223fs|IFT122_ENST00000504021.1_Frame_Shift_Ins_p.R125fs|IFT122_ENST00000431818.2_Frame_Shift_Ins_p.R22fs	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	172					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium		p.P223P(1)		breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						ATCGAGCGGCCGGGGGGCTCCC	0.505													8	324	---	---	---	---					
PLXND1	23129	broad.mit.edu	37	3	129324871	129324872	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:129324871_129324872insC	ENST00000393239.1	-	1	789_790	c.611_612insG	c.(610-612)gagfs	p.E204fs	PLXND1_ENST00000324093.4_Frame_Shift_Ins_p.E204fs			Q9Y4D7	PLXD1_HUMAN	plexin D1	204	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GCAGGCGGCTgccccccgcgcc	0.708													2	4	---	---	---	---					
COL6A6	131873	broad.mit.edu	37	3	130281934	130281935	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:130281934_130281935insT	ENST00000358511.6	+	2	118_119	c.87_88insT	c.(85-90)gtttttfs	p.VF29fs	COL6A6_ENST00000453409.2_Frame_Shift_Ins_p.VF29fs	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	29	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CAGATGTTGTGTTTTTGGTGGA	0.431													8	723	---	---	---	---					
TF	7018	broad.mit.edu	37	3	133476713	133476714	+	Frame_Shift_Ins	INS	-	-	C	rs148358704		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:133476713_133476714insC	ENST00000402696.3	+	8	1456_1457	c.971_972insC	c.(970-972)gccfs	p.A324fs	TF_ENST00000264998.3_Frame_Shift_Ins_p.A197fs	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	324	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TTTTTAAAAGTCCCCCCCAGGA	0.485													7	204	---	---	---	---					
STAG1	10274	broad.mit.edu	37	3	136141378	136141379	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:136141378_136141379delAC	ENST00000383202.2	-	19	2166_2167	c.1910_1911delGT	c.(1909-1911)afs	p.S637fs	STAG1_ENST00000434713.2_Frame_Shift_Del_p.S411fs|STAG1_ENST00000236698.5_Frame_Shift_Del_p.S637fs|STAG1_ENST00000536929.1_Frame_Shift_Del_p.S221fs	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	637					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TATAGGTTTTACTGCAGGCTTC	0.371													33	108	---	---	---	---					
LOC100507291	100507291	broad.mit.edu	37	3	139212981	139212982	+	RNA	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:139212981_139212982insC	ENST00000515247.1	+	0	317																											GATGACCAAGGCCCCCCCTTGT	0.530													7	117	---	---	---	---					
GRK7	131890	broad.mit.edu	37	3	141535707	141535708	+	Frame_Shift_Ins	INS	-	-	G	rs149574289		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:141535707_141535708insG	ENST00000264952.2	+	4	1614_1615	c.1477_1478insG	c.(1477-1479)gggfs	p.G493fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	493	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.R493L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTCTGAGGTTCGGGGGGTGGAA	0.460													15	794	---	---	---	---					
KPNA4	3840	broad.mit.edu	37	3	160245789	160245789	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:160245789delG	ENST00000334256.4	-	8	813	c.508delC	c.(508-510)atfs	p.H170fs		NM_002268.4	NP_002259.1	O00629	IMA4_HUMAN	karyopherin alpha 4 (importin alpha 3)	170	NLS binding site (major) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)	22			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ACATTCTGATGGGGTGAATGG	0.348													48	51	---	---	---	---					
BCHE	590	broad.mit.edu	37	3	165547909	165547915	+	Frame_Shift_Del	DEL	CTTCATT	CTTCATT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:165547909_165547915delCTTCATT	ENST00000264381.3	-	2	1073_1079	c.907_913delAATGAAG	c.(907-915)cafs	p.NEA303fs	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	303					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ACAACAAATGCTTCATTCAGAAGAATT	0.401													33	123	---	---	---	---					
FNDC3B	64778	broad.mit.edu	37	3	172096209	172096210	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:172096209_172096210insC	ENST00000336824.4	+	24	3257_3258	c.3158_3159insC	c.(3157-3159)gccfs	p.A1053fs	FNDC3B_ENST00000415807.2_Frame_Shift_Ins_p.A1053fs|FNDC3B_ENST00000416957.1_Frame_Shift_Ins_p.A1053fs	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1053						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACCAAAAGTGTCCCCCCCACCA	0.470													9	177	---	---	---	---					
HTR3C	170572	broad.mit.edu	37	3	183777416	183777417	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:183777416_183777417insC	ENST00000318351.1	+	7	947_948	c.913_914insC	c.(913-915)cccfs	p.P305fs		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	305						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGCCAGTGGCACCCCCCTCATC	0.584													8	629	---	---	---	---					
LPP	4026	broad.mit.edu	37	3	188478066	188478066	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr3:188478066delA	ENST00000312675.4	+	8	1652	c.1406delA	c.(1405-1407)tcfs	p.Y469fs	LPP_ENST00000543006.1_Frame_Shift_Del_p.Y469fs	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	469	LIM zinc-binding 1.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GAGCCCTGCTACATTGTAAGT	0.453			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								11	250	---	---	---	---					
LETM1	3954	broad.mit.edu	37	4	1843235	1843236	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:1843235_1843236insG	ENST00000302787.2	-	3	728_729	c.432_433insC	c.(430-435)cccagafs	p.R145fs		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	145					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			ACCACCTCTGCGGGGGGGCTGT	0.604													22	330	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2661592	2661593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:2661592_2661593insC	ENST00000324666.5	+	8	1034_1035	c.683_684insC	c.(682-684)gccfs	p.A228fs	FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.A252fs|FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.A228fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	228										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GGTATCATGGACCCCCCCGTCA	0.525													17	778	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2674078	2674079	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:2674078_2674079insC	ENST00000324666.5	+	11	1788_1789	c.1437_1438insC	c.(1435-1440)acccccfs	p.TP479fs	FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.TP479fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.TP501fs|FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.TP479fs|FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.TP479fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	479										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGTATGCAACGCCCCCCTTCAC	0.510													7	258	---	---	---	---					
ZBTB49	166793	broad.mit.edu	37	4	4304018	4304019	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:4304018_4304019insC	ENST00000337872.4	+	3	576_577	c.455_456insC	c.(454-456)tccfs	p.S152fs	ZBTB49_ENST00000355834.3_Frame_Shift_Ins_p.S152fs|ZBTB49_ENST00000538529.1_5'UTR	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						AGTGAAAACTACCCCCCTCATT	0.470													7	276	---	---	---	---					
CPEB2	132864	broad.mit.edu	37	4	15067857	15067858	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:15067857_15067858insT	ENST00000538197.1	+	12	2958_2959	c.2958_2959insT	c.(2956-2961)ccttttfs	p.PF986fs	RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000507071.1_Frame_Shift_Ins_p.PF541fs|CPEB2_ENST00000382401.3_Frame_Shift_Ins_p.PF514fs|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000345451.3_Frame_Shift_Ins_p.PF511fs|CPEB2_ENST00000259997.5_Frame_Shift_Ins_p.PF549fs|CPEB2_ENST00000442003.2_Frame_Shift_Ins_p.PF959fs|CPEB2_ENST00000382395.3_Frame_Shift_Ins_p.PF519fs|CPEB2_ENST00000541112.1_Frame_Shift_Ins_p.PF978fs	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	541					regulation of translation	cytoplasm	nucleotide binding|RNA binding	p.P541P(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						AATTTGCTCCCTTTTTTTGTGC	0.441													10	423	---	---	---	---					
KLF3	51274	broad.mit.edu	37	4	38691475	38691476	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:38691475_38691476insC	ENST00000261438.5	+	4	975_976	c.670_671insC	c.(670-672)cccfs	p.P224fs	KLF3_ENST00000514033.1_Frame_Shift_Ins_p.P224fs	NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	224	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						GAACTCAGTGTCCCCCCCGCAA	0.426													7	353	---	---	---	---					
CORIN	10699	broad.mit.edu	37	4	47676518	47676519	+	Splice_Site	INS	-	-	TT			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:47676518_47676519insTT	ENST00000273857.4	-	10	1249		c.e10-1		CORIN_ENST00000504584.1_Splice_Site|CORIN_ENST00000508498.1_Splice_Site|CORIN_ENST00000505909.1_Splice_Site|CORIN_ENST00000502252.1_Splice_Site	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase						peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GAAGTCTGAACTACAGAGGGAG	0.441													56	421	---	---	---	---					
ENAM	10117	broad.mit.edu	37	4	71503554	71503555	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:71503554_71503555insG	ENST00000396073.3	+	8	863_864	c.582_583insG	c.(580-585)gaggggfs	p.EG194fs	ENAM_ENST00000472903.1_3'UTR	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	194					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			GCAATGAAGAAGGGGGGGTAAG	0.431													17	380	---	---	---	---					
FRAS1	80144	broad.mit.edu	37	4	79238582	79238583	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:79238582_79238583insC	ENST00000264895.6	+	17	2320_2321	c.1880_1881insC	c.(1879-1881)accfs	p.T627fs	FRAS1_ENST00000264899.6_Frame_Shift_Ins_p.T627fs|FRAS1_ENST00000325942.6_Frame_Shift_Ins_p.T627fs	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	627					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ACAGCCTGCAGCCCCCCCAAGG	0.574													8	112	---	---	---	---					
HPGDS	27306	broad.mit.edu	37	4	95223320	95223321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:95223320_95223321insC	ENST00000295256.5	-	5	501_502	c.411_412insG	c.(409-414)gggagafs	p.R138fs		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	138	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	AGCCATTCTCTCCCCCCTAAAT	0.351													7	555	---	---	---	---					
UNC5C	8633	broad.mit.edu	37	4	96140293	96140294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:96140293_96140294insG	ENST00000453304.1	-	9	1819_1820	c.1471_1472insC	c.(1471-1473)agafs	p.R491fs	UNC5C_ENST00000506749.1_Frame_Shift_Ins_p.R510fs	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	491					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAGGTCATCTTGGGGGGTGACA	0.505													14	659	---	---	---	---					
EGF	1950	broad.mit.edu	37	4	110909773	110909774	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:110909773_110909774insC	ENST00000265171.5	+	18	3087_3088	c.2642_2643insC	c.(2641-2643)tccfs	p.S881fs	EGF_ENST00000503392.1_Frame_Shift_Ins_p.S881fs|EGF_ENST00000509793.1_Frame_Shift_Ins_p.S839fs	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	881	EGF-like 7; calcium-binding (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTCCCAGTGTGCCCCCCTGCCT	0.470													10	323	---	---	---	---					
C4orf32	132720	broad.mit.edu	37	4	113107915	113107916	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:113107915_113107916insT	ENST00000309733.4	+	2	404_405	c.220_221insT	c.(220-222)tttfs	p.F74fs		NM_152400.2	NP_689613.1	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	74						integral to membrane							Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		AATGGGAACACTTTTTGGTGAA	0.366													8	760	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134071648	134071649	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:134071648_134071649insC	ENST00000264360.4	+	1	1179_1180	c.353_354insC	c.(352-354)accfs	p.T118fs		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	118	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S121fs*13(1)		NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTAATGACAACCCCCCCTCTT	0.604													7	213	---	---	---	---					
FGG	2266	broad.mit.edu	37	4	155526058	155526059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:155526058_155526059insC	ENST00000404648.3	-	9	1528_1529	c.1289_1290insG	c.(1288-1290)ggcfs	p.G430fs	FGG_ENST00000336098.3_Frame_Shift_Ins_p.G430fs|FGG_ENST00000407946.1_Frame_Shift_Ins_p.G438fs|FGG_ENST00000405164.1_Frame_Shift_Ins_p.G438fs	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	430	Platelet aggregation and Staphylococcus clumping.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CCTGTTTGGCTCCCCCCAGGTG	0.450													10	609	---	---	---	---					
SNX25	83891	broad.mit.edu	37	4	186188239	186188240	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:186188239_186188240insC	ENST00000504273.1	+	5	823_824	c.529_530insC	c.(529-531)cccfs	p.P177fs	SNX25_ENST00000264694.8_Frame_Shift_Ins_p.P177fs			Q9H3E2	SNX25_HUMAN	sorting nexin 25	177					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CTACACCTATGCCCCCTCTTAC	0.441													10	381	---	---	---	---					
TLR3	7098	broad.mit.edu	37	4	186997804	186997805	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:186997804_186997805insG	ENST00000296795.2	+	2	135_136	c.31_32insG	c.(31-33)gggfs	p.G11fs		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	11					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TATCTACTTTTGGGGGGGCCTT	0.446													28	587	---	---	---	---					
TRIML2	205860	broad.mit.edu	37	4	189012770	189012771	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr4:189012770_189012771insG	ENST00000512729.1	-	7	1294_1295	c.920_921insC	c.(919-921)cctfs	p.P307fs	TRIML2_ENST00000326754.3_Frame_Shift_Ins_p.P332fs	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	307	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GCCTTTTCAGAGGGGGGAAGAC	0.559													8	354	---	---	---	---					
SEMA5A	9037	broad.mit.edu	37	5	9044549	9044550	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:9044549_9044550insG	ENST00000382496.5	-	22	3705_3706	c.3040_3041insC	c.(3040-3042)taafs	p.*1014fs	CTD-2215L10.1_ENST00000506519.1_RNA	NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	1014					cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GCTGGTATTAAGGGGGGCAGGT	0.525													8	1316	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24487951	24487952	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:24487951_24487952insG	ENST00000264463.4	-	12	2694_2695	c.2187_2188insC	c.(2185-2190)ccacgafs	p.R730fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	730					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGTGAGTCGTAGGGGGGTGCGG	0.460										HNSCC(23;0.051)			8	502	---	---	---	---					
SLC1A3	6507	broad.mit.edu	37	5	36679798	36679799	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:36679798_36679799insG	ENST00000265113.4	+	7	1406_1407	c.930_931insG	c.(928-933)atggggfs	p.MG310fs	CTD-2353F22.1_ENST00000510740.1_RNA|SLC1A3_ENST00000381918.3_Frame_Shift_Ins_p.MG310fs	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	310					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TGGGTGTGATTGGGGGGCAGCT	0.520													29	1419	---	---	---	---					
EGFLAM	133584	broad.mit.edu	37	5	38407191	38407192	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:38407191_38407192insG	ENST00000322350.5	+	8	1436_1437	c.1090_1091insG	c.(1090-1092)gggfs	p.G364fs	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Frame_Shift_Ins_p.G130fs|EGFLAM_ENST00000354891.3_Frame_Shift_Ins_p.G364fs	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	364	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse		p.S367fs*12(1)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGACTACACCTGGGGGGGCTCG	0.545													10	260	---	---	---	---					
FYB	2533	broad.mit.edu	37	5	39202090	39202091	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:39202090_39202091insC	ENST00000351578.6	-	2	1162_1163	c.972_973insG	c.(970-975)ggcatgfs	p.M325fs	FYB_ENST00000515010.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000505428.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000540520.1_Frame_Shift_Ins_p.M335fs|FYB_ENST00000512982.1_Frame_Shift_Ins_p.M325fs	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	325					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P325A(3)|p.P335A(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCCCATGGCCCCCCCACTG	0.540													11	116	---	---	---	---					
MOCS2	4338	broad.mit.edu	37	5	52402939	52402940	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:52402939_52402940insG	ENST00000361377.4	-	3	293_294	c.252_253insC	c.(250-255)ccttagfs	p.*85fs	MOCS2_ENST00000508922.1_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000582677.1_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000450852.3_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000584946.1_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000510818.2_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000396954.3_Frame_Shift_Ins_p.L22fs			O96033	MOC2A_HUMAN	molybdenum cofactor synthesis 2	85					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding			endometrium(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				CCTCCACTAATGGGGGGGATAA	0.426													17	390	---	---	---	---					
MAP1B	4131	broad.mit.edu	37	5	71490419	71490420	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:71490419_71490420insA	ENST00000296755.7	+	5	1535_1536	c.1237_1238insA	c.(1237-1239)aaafs	p.K413fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	413						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CATTCTTTTCCAAAAAATGGGA	0.401													7	872	---	---	---	---					
MAP1B	4131	broad.mit.edu	37	5	71495076	71495077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:71495076_71495077insC	ENST00000296755.7	+	5	6192_6193	c.5894_5895insC	c.(5893-5895)accfs	p.T1965fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1965						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCACCAGCCCCCCCGAAG	0.485													11	256	---	---	---	---					
BHMT2	23743	broad.mit.edu	37	5	78378743	78378744	+	Frame_Shift_Ins	INS	-	-	C	rs139619947		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:78378743_78378744insC	ENST00000255192.3	+	5	628_629	c.562_563insC	c.(562-564)cccfs	p.P188fs	DMGDH_ENST00000520388.1_Intron|BHMT2_ENST00000521567.1_Frame_Shift_Ins_p.P124fs	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	188	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GCATGATATAACCCCCGGAGAA	0.480													8	1170	---	---	---	---					
CEP120	153241	broad.mit.edu	37	5	122713212	122713213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:122713212_122713213insT	ENST00000306467.5	-	16	2517_2518	c.2213_2214insA	c.(2212-2214)agafs	p.R738fs	CEP120_ENST00000328236.5_Frame_Shift_Ins_p.R738fs|CEP120_ENST00000306481.6_Frame_Shift_Ins_p.R712fs			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	738						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						ATTGCAGTTCCTTTTTTTCTCT	0.391													9	290	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127610310	127610311	+	Frame_Shift_Ins	INS	-	-	C	rs151053868		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:127610310_127610311insC	ENST00000508053.1	-	66	8633_8634	c.7659_7660insG	c.(7657-7662)ggttacfs	p.Y2554fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.Y2554fs			P35556	FBN2_HUMAN	fibrillin 2	2554	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTACAGGTAAACCCCCCCAGGG	0.421													8	244	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127648336	127648337	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:127648336_127648337insG	ENST00000508053.1	-	43	5842_5843	c.4868_4869insC	c.(4867-4869)cgtfs	p.R1623fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.R1623fs			P35556	FBN2_HUMAN	fibrillin 2	1623	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.P1623P(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGCTATTGACAGGGGGGCATGT	0.505													9	905	---	---	---	---					
SLC22A5	6584	broad.mit.edu	37	5	131722730	131722731	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:131722730_131722731insC	ENST00000245407.3	+	5	1059_1060	c.838_839insC	c.(838-840)cccfs	p.P280fs	SLC22A5_ENST00000435065.2_Frame_Shift_Ins_p.P304fs	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	280					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CATCCCTGAGTCCCCCCGATGG	0.545											OREG0016767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	1081	---	---	---	---					
HSPA4	3308	broad.mit.edu	37	5	132432907	132432907	+	Frame_Shift_Del	DEL	G	G	-	rs143003242	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:132432907delG	ENST00000304858.2	+	15	2147	c.1858delG	c.(1858-1860)cafs	p.A620fs		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	620					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCTAAGAACGCAGTGGAGGA	0.373													14	580	---	---	---	---					
KDM3B	51780	broad.mit.edu	37	5	137727193	137727194	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:137727193_137727194insC	ENST00000314358.5	+	8	2072_2073	c.1872_1873insC	c.(1870-1875)caccccfs	p.HP624fs	KDM3B_ENST00000394866.1_Frame_Shift_Ins_p.HP280fs|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	624					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TATTTTTACAGCCCCCCAAATT	0.505													7	130	---	---	---	---					
EGR1	1958	broad.mit.edu	37	5	137803131	137803132	+	Frame_Shift_Ins	INS	-	-	C	rs148475837		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:137803131_137803132insC	ENST00000239938.4	+	2	1265_1266	c.993_994insC	c.(991-996)acccccfs	p.TP331fs		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	331					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCAGCAAGACGCCCCCCCACGA	0.649													24	345	---	---	---	---					
PCDHA2	56146	broad.mit.edu	37	5	140176837	140176838	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:140176837_140176838insC	ENST00000526136.1	+	1	2288_2289	c.2288_2289insC	c.(2287-2289)gccfs	p.A763fs	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Frame_Shift_Ins_p.A763fs|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Frame_Shift_Ins_p.A763fs	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGGGGAGGACCCCCCCAAGA	0.619													9	127	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049341	141049342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:141049341_141049342insC	ENST00000239440.4	-	16	2351_2352	c.2286_2287insG	c.(2284-2289)ggggatfs	p.D763fs	ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.D425fs|ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.D665fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	763					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGCTGGATCCTCCCCCCAGCGA	0.579													8	529	---	---	---	---					
PCDH12	51294	broad.mit.edu	37	5	141336747	141336748	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:141336747_141336748insG	ENST00000231484.3	-	1	1879_1880	c.669_670insC	c.(667-672)ccagtcfs	p.V224fs		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	224	Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACCTGACTTGGGGGGGTTCC	0.480													22	351	---	---	---	---					
SPRY4	81848	broad.mit.edu	37	5	141694153	141694154	+	Frame_Shift_Ins	INS	-	-	G	rs144353509		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:141694153_141694154insG	ENST00000344120.4	-	3	775_776	c.589_590insC	c.(589-591)gacfs	p.D197fs	SPRY4_ENST00000434127.2_Frame_Shift_Ins_p.D174fs	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	174	Cys-rich.|SPR.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCAACGTCCGGGGGGATGCA	0.609									Testicular Cancer, Familial Clustering of				7	318	---	---	---	---					
PPP2R2B	5521	broad.mit.edu	37	5	145969651	145969652	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:145969651_145969652insC	ENST00000394413.3	-	9	1760_1761	c.1190_1191insG	c.(1189-1191)gaafs	p.E397fs	PPP2R2B_ENST00000453001.1_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000394414.1_Frame_Shift_Ins_p.E463fs|PPP2R2B_ENST00000356826.3_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000336640.6_Frame_Shift_Ins_p.E400fs|CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000394411.4_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000504198.1_Frame_Shift_Ins_p.E403fs|PPP2R2B_ENST00000394410.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000508545.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394409.3_Frame_Shift_Ins_p.E455fs			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	397					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTCCGCTTGCCCCCCACACA	0.500													8	544	---	---	---	---					
GABRA6	2559	broad.mit.edu	37	5	161116011	161116012	+	Frame_Shift_Ins	INS	-	-	G	rs143274925		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:161116011_161116012insG	ENST00000523217.1	+	4	494_495	c.252_253insG	c.(250-255)ttggggfs	p.LG84fs	GABRA6_ENST00000274545.5_Frame_Shift_Ins_p.LG94fs|RP11-348M17.2_ENST00000521984.1_RNA	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	94					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGTTGAAGTTTGGGGGGCCAAC	0.406										TCGA Ovarian(5;0.080)			14	865	---	---	---	---					
WWC1	23286	broad.mit.edu	37	5	167850576	167850577	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:167850576_167850577insC	ENST00000265293.4	+	11	1815_1816	c.1313_1314insC	c.(1312-1314)accfs	p.T438fs	WWC1_ENST00000521089.1_Frame_Shift_Ins_p.T438fs	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	438					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		TCAGGCAGCAGCCCCGGATCCC	0.614													7	2448	---	---	---	---					
STK10	6793	broad.mit.edu	37	5	171517344	171517345	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:171517344_171517345insT	ENST00000176763.5	-	10	1919_1920	c.1576_1577insA	c.(1576-1578)cctfs	p.P526fs		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	526							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCGCTTGAGGGTTTTTTTGTAC	0.515													13	772	---	---	---	---					
KIAA1191	57179	broad.mit.edu	37	5	175774701	175774702	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr5:175774701_175774702insG	ENST00000298569.4	-	9	1352_1353	c.819_820insC	c.(817-822)ccagatfs	p.D274fs	KIAA1191_ENST00000393725.2_Frame_Shift_Ins_p.D255fs|KIAA1191_ENST00000393728.2_5'UTR|KIAA1191_ENST00000510164.1_Frame_Shift_Ins_p.D274fs	NM_020444.3	NP_065177.2	Q96A73	K1191_HUMAN	KIAA1191	274							protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)		ATGTCCATCTTGGGGGGCTTCA	0.579													9	435	---	---	---	---					
EXOC2	55770	broad.mit.edu	37	6	637793	637794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:637793_637794insG	ENST00000230449.4	-	2	160_161	c.25_26insC	c.(25-27)tgtfs	p.C9fs	EXOC2_ENST00000448181.3_Intron	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	9	IPT/TIG.				exocytosis|protein transport			p.Q6fs*28(1)		breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GCCGGTCACAAGGGGGGGTTGT	0.485													35	782	---	---	---	---					
WRNIP1	56897	broad.mit.edu	37	6	2785481	2785482	+	Frame_Shift_Ins	INS	-	-	G	rs144391691		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:2785481_2785482insG	ENST00000380769.4	+	7	1534_1535	c.1303_1304insG	c.(1303-1305)gggfs	p.G435fs	WRNIP1_ENST00000380771.4_Frame_Shift_Ins_p.G630fs|WRNIP1_ENST00000380773.4_Frame_Shift_Ins_p.G655fs|WRNIP1_ENST00000380764.1_Frame_Shift_Ins_p.G271fs			Q96S55	WRIP1_HUMAN	Werner helicase interacting protein 1	655					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				TGAAGAGTTGAGGGGGGTAGAT	0.520													9	422	---	---	---	---					
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:13206134_13206135insG	ENST00000379350.1	+	7	881_882	c.752_753insG	c.(751-753)gggfs	p.G251fs	PHACTR1_ENST00000457702.2_Frame_Shift_Ins_p.G106fs|PHACTR1_ENST00000332995.7_Frame_Shift_Ins_p.G251fs|PHACTR1_ENST00000379345.2_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599													17	314	---	---	---	---					
NRSN1	140767	broad.mit.edu	37	6	24145844	24145845	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:24145844_24145845insC	ENST00000378491.4	+	4	559_560	c.258_259insC	c.(256-261)gtccccfs	p.VP86fs		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	86					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						GCTTTCTTGTGCCCCCCAAAAT	0.485													7	212	---	---	---	---					
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:24205282_24205283insC	ENST00000378454.3	-	8	1271_1272	c.970_971insG	c.(970-972)agcfs	p.S324fs	DCDC2_ENST00000378450.3_Frame_Shift_Ins_p.S77fs	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411													25	1181	---	---	---	---					
GABBR1	2550	broad.mit.edu	37	6	29577143	29577144	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:29577143_29577144insG	ENST00000377034.4	-	15	2056_2057	c.1721_1722insC	c.(1720-1722)cgcfs	p.R574fs	GABBR1_ENST00000376977.3_Intron|GABBR1_ENST00000377012.4_Frame_Shift_Ins_p.R457fs|GABBR1_ENST00000377016.4_Frame_Shift_Ins_p.R512fs|GABBR1_ENST00000355973.3_Frame_Shift_Ins_p.R457fs	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	574					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TCTGGTCAGCTGGGGGGGACCC	0.540													20	318	---	---	---	---					
DDR1	780	broad.mit.edu	37	6	30867830	30867831	+	Frame_Shift_Ins	INS	-	-	G	rs146246499	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:30867830_30867831insG	ENST00000361741.4	+	12	1492_1493	c.1297_1298insG	c.(1297-1299)gggfs	p.G433fs	DDR1_ENST00000452441.1_3'UTR|DDR1_ENST00000376568.3_3'UTR|DDR1_ENST00000376567.2_3'UTR|DDR1_ENST00000454612.2_3'UTR|DDR1_ENST00000376570.4_3'UTR|DDR1_ENST00000324771.8_3'UTR|DDR1_ENST00000376569.3_3'UTR|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376575.3_3'UTR			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	0					cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	TGTACATTTTTGGGGGGAGAGA	0.441													12	370	---	---	---	---					
DDX39B	7919	broad.mit.edu	37	6	31500690	31500691	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31500690_31500691insG	ENST00000417556.2	-	8	1411		c.e8-2		DDX39B_ENST00000376177.2_Splice_Site|DDX39B_ENST00000458640.1_Splice_Site|DDX39B_ENST00000396172.1_Splice_Site|DDX39B_ENST00000415382.2_Splice_Site|ATP6V1G2-DDX39B_ENST00000376185.1_Splice_Site			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B						intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CTCCATTGGCTgggggggagga	0.579													19	353	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608570	31608571	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31608570_31608571insG	ENST00000404765.2	-	21	3221_3222	c.2934_splice	c.e21+1	p.A978_splice	BAG6_ENST00000362049.6_Splice_Site_p.A942_splice|BAG6_ENST00000375976.4_Splice_Site_p.A942_splice|BAG6_ENST00000439687.2_Splice_Site_p.A816_splice|BAG6_ENST00000375964.6_Splice_Site_p.A948_splice|BAG6_ENST00000211379.5_Splice_Site_p.A942_splice			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	948					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTCCCTTACCTGGGGGGGATCA	0.535													12	587	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608920	31608921	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31608920_31608921insC	ENST00000404765.2	-	20	3036_3037	c.2747_2748insG	c.(2746-2748)gcafs	p.A916fs	BAG6_ENST00000362049.6_Frame_Shift_Ins_p.A880fs|BAG6_ENST00000375976.4_Frame_Shift_Ins_p.A880fs|BAG6_ENST00000439687.2_Frame_Shift_Ins_p.A754fs|BAG6_ENST00000375964.6_Frame_Shift_Ins_p.A886fs|BAG6_ENST00000211379.5_Frame_Shift_Ins_p.A880fs			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	886					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CCATCTGCTGTCCCCCCAAGCA	0.515													11	807	---	---	---	---					
C6orf25	80739	broad.mit.edu	37	6	31692528	31692529	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31692528_31692529insC	ENST00000375809.3	+	5	558_559	c.547_548insC	c.(547-549)cccfs	p.P183fs	C6orf25_ENST00000375810.4_Frame_Shift_Ins_p.P183fs|C6orf25_ENST00000480039.1_Intron|C6orf25_ENST00000375805.2_Frame_Shift_Ins_p.CP152fs	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TTCAGCTCTGTCCCCCCCACAT	0.579													11	227	---	---	---	---					
VARS	7407	broad.mit.edu	37	6	31759454	31759455	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31759454_31759455insG	ENST00000375663.3	-	8	1472_1473	c.1032_1033insC	c.(1030-1035)ccatgtfs	p.C345fs	VARS_ENST00000444930.2_Frame_Shift_Ins_p.C50fs	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	345					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	CCTGTCACATTGGGGGGTGGGA	0.564													11	505	---	---	---	---					
CFB	629	broad.mit.edu	37	6	31911214	31911215	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31911214_31911215insG	ENST00000456570.1	+	9	1073_1074	c.1018_1019insG	c.(1018-1020)gggfs	p.G340fs	C2_ENST00000469372.1_Frame_Shift_Ins_p.G247fs|C2_ENST00000442278.2_Frame_Shift_Ins_p.G361fs|C2_ENST00000452323.2_Frame_Shift_Ins_p.G279fs|CFB_ENST00000556679.1_Frame_Shift_Ins_p.G340fs|CFB_ENST00000477310.1_Frame_Shift_Ins_p.G264fs|C2_ENST00000299367.5_Frame_Shift_Ins_p.G493fs			P00751	CFAB_HUMAN	complement factor B	512	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						AGAGACCTGCCGGGGGGCCCTC	0.589													7	299	---	---	---	---					
SKIV2L	6499	broad.mit.edu	37	6	31937382	31937383	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:31937382_31937383insG	ENST00000375394.2	+	28	3744_3745	c.3631_3632insG	c.(3631-3633)gggfs	p.G1211fs	SKIV2L_ENST00000544581.1_Frame_Shift_Ins_p.G1018fs	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	1211						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TCGCTCACTGCGGGGGGCAGCC	0.653													7	151	---	---	---	---					
TNXB	7148	broad.mit.edu	37	6	32020535	32020536	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:32020535_32020536insC	ENST00000375244.3	-	26	9227_9228	c.9026_9027insG	c.(9025-9027)gctfs	p.A3009fs	TNXB_ENST00000375247.2_Frame_Shift_Ins_p.A3007fs			P22105	TENX_HUMAN	tenascin XB	3054	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGGGCTCCAGGCCCCCCACGGT	0.663													7	160	---	---	---	---					
FKBPL	63943	broad.mit.edu	37	6	32097085	32097086	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:32097085_32097086insC	ENST00000375156.3	-	2	742_743	c.472_473insG	c.(472-474)gctfs	p.A158fs		NM_022110.3	NP_071393.2	Q9UIM3	FKBPL_HUMAN	FK506 binding protein like	158					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity										CTCTATGAGCTCCCCCCAAGTT	0.589													12	404	---	---	---	---					
COL11A2	1302	broad.mit.edu	37	6	33134298	33134299	+	Frame_Shift_Ins	INS	-	-	G	rs148262058	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:33134298_33134299insG	ENST00000341947.2	-	60	4610_4611	c.4383_4384insC	c.(4381-4386)ccgcctfs	p.P1462fs	COL11A2_ENST00000374713.1_Frame_Shift_Ins_p.P1415fs|COL11A2_ENST00000374708.4_Frame_Shift_Ins_p.P1376fs|COL11A2_ENST00000361917.1_Frame_Shift_Ins_p.P1355fs|COL11A2_ENST00000395197.1_Frame_Shift_Ins_p.P1402fs|COL11A2_ENST00000374714.1_Frame_Shift_Ins_p.P1436fs|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374712.1_Frame_Shift_Ins_p.P1381fs|COL11A2_ENST00000357486.1_Frame_Shift_Ins_p.P1441fs	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1462	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging	p.P1461P(1)		biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						ACGGGGAGGCCGGGGGGACCTC	0.619													7	160	---	---	---	---					
PHF1	5252	broad.mit.edu	37	6	33383636	33383637	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:33383636_33383637insC	ENST00000374516.3	+	15	1736_1737	c.1465_1466insC	c.(1465-1467)cccfs	p.P489fs	PHF1_ENST00000374512.3_Frame_Shift_Ins_p.VP453fs	NM_024165.2	NP_077084.1	O43189	PHF1_HUMAN	PHD finger protein 1	489					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A489V(1)|p.H491fs*3(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19		Ovarian(999;0.0443)				CCCTAAAAGTGCCCCCCACTCG	0.530													10	555	---	---	---	---					
UHRF1BP1	54887	broad.mit.edu	37	6	34791081	34791082	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:34791081_34791082insC	ENST00000192788.5	+	4	465_466	c.294_295insC	c.(292-297)cgccccfs	p.RP98fs	UHRF1BP1_ENST00000452449.2_Frame_Shift_Ins_p.RP98fs	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	98										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AGGATCCTCGGCCCCCCAATGG	0.446													19	918	---	---	---	---					
TCP11	6954	broad.mit.edu	37	6	35108559	35108560	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:35108559_35108560insG	ENST00000311875.5	-	2	544_545	c.127_128insC	c.(127-129)ggafs	p.G43fs	TCP11_ENST00000373979.2_Intron|TCP11_ENST00000412155.2_Intron|TCP11_ENST00000244645.3_5'UTR|TCP11_ENST00000444780.2_Frame_Shift_Ins_p.G43fs|TCP11_ENST00000418521.2_Intron|TCP11_ENST00000510465.1_5'UTR|TCP11_ENST00000512012.1_Frame_Shift_Ins_p.G30fs|TCP11_ENST00000373974.4_Intron			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	30					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						CTTGTCTTCCTGGGGGGGTCCT	0.639													8	236	---	---	---	---					
FANCE	2178	broad.mit.edu	37	6	35425714	35425715	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:35425714_35425715insC	ENST00000229769.2	+	4	1107_1108	c.922_923insC	c.(922-924)cccfs	p.P308fs		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	308	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						ATTGGAGGATGCCCCCCCAGTT	0.540			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				38	832	---	---	---	---					
MAPK14	1432	broad.mit.edu	37	6	36068005	36068006	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:36068005_36068006insC	ENST00000229795.3	+	9	1170_1171	c.723_724insC	c.(721-726)acccccfs	p.TP241fs	MAPK14_ENST00000468133.1_Intron|MAPK14_ENST00000229794.4_Intron|MAPK14_ENST00000310795.4_Intron	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	241	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						TGACAGGAACACCCCCCGCTTA	0.426													15	971	---	---	---	---					
STK38	11329	broad.mit.edu	37	6	36463592	36463593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:36463592_36463593insC	ENST00000229812.7	-	14	1651_1652	c.1366_1367insG	c.(1366-1368)aatfs	p.N456fs		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	456					intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGAAGGTATTGCCCCCCTTGCA	0.455													7	346	---	---	---	---					
MOCS1	4337	broad.mit.edu	37	6	39874149	39874150	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:39874149_39874150insC	ENST00000308559.7	-	10	1979_1980	c.1846_1847insG	c.(1846-1848)cttfs	p.L616fs	MOCS1_ENST00000340692.5_Frame_Shift_Ins_p.L632fs|MOCS1_ENST00000373175.4_3'UTR|MOCS1_ENST00000373188.2_3'UTR|MOCS1_ENST00000425303.2_Frame_Shift_Ins_p.L632fs|MOCS1_ENST00000373186.4_3'UTR|MOCS1_ENST00000373195.3_Frame_Shift_Ins_p.L529fs			Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	632	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCGATGGAAGTCCCCCCGCTGA	0.579													12	616	---	---	---	---					
RUNX2	860	broad.mit.edu	37	6	45514855	45514856	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:45514855_45514856insG	ENST00000371438.1	+	8	1737_1738	c.1379_1380insG	c.(1378-1380)cggfs	p.R460fs	RUNX2_ENST00000576263.1_Intron|RUNX2_ENST00000359524.5_Frame_Shift_Ins_p.R446fs|RUNX2_ENST00000465038.2_Frame_Shift_Ins_p.R460fs|RUNX2_ENST00000371436.6_Frame_Shift_Ins_p.R438fs|RUNX2_ENST00000371432.3_Frame_Shift_Ins_p.R424fs|RUNX2_ENST00000541979.1_Frame_Shift_Ins_p.R506fs|RUNX2_ENST00000352853.5_Frame_Shift_Ins_p.R528fs	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	460	Interaction with MYST4.|Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.G462fs*22(1)|p.G530fs*22(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CCCATGGTGCCGGGGGGAGACC	0.545													7	319	---	---	---	---					
MEP1A	4224	broad.mit.edu	37	6	46806746	46806747	+	Frame_Shift_Ins	INS	-	-	G	rs141276985	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:46806746_46806747insG	ENST00000230588.4	+	14	2123_2124	c.2114_2115insG	c.(2113-2115)aggfs	p.R705fs		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	705	EGF-like.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding	p.T705T(1)		NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TTCTTCTACACGGGGGAGCGCT	0.584													9	1801	---	---	---	---					
GPR115	221393	broad.mit.edu	37	6	47680115	47680115	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:47680115delT	ENST00000283303.2	+	5	581	c.323delT	c.(322-324)ctfs	p.L108fs	GPR115_ENST00000327753.3_Frame_Shift_Del_p.L108fs|GPR115_ENST00000371220.1_Frame_Shift_Del_p.L165fs	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	108					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GCATCTCGCCTTTCTGTAGCA	0.408													293	192	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55039410	55039411	+	Frame_Shift_Ins	INS	-	-	C	rs76774128		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:55039410_55039411insC	ENST00000370862.3	+	1	361_362	c.25_26insC	c.(25-27)cccfs	p.P9fs		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	9					feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.P11fs*11(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATTGGAGGACTCCCCCCCTTGT	0.564													27	468	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55113573	55113574	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:55113573_55113574insT	ENST00000370862.3	+	2	696_697	c.360_361insT	c.(358-363)tgttttfs	p.CF120fs		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	120					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGAGACCTGGTTTTTTGGACA	0.431													11	646	---	---	---	---					
DST	667	broad.mit.edu	37	6	56471391	56471392	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:56471391_56471392delAG	ENST00000370754.5	-	39	7934_7935	c.7935_7936delCT	c.(7933-7938)agtafs	p.SL2645fs	DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000312431.6_Frame_Shift_Del_p.SL2467fs|DST_ENST00000370769.4_Frame_Shift_Del_p.SL2467fs|DST_ENST00000446842.2_Frame_Shift_Del_p.SL2141fs|DST_ENST00000361203.3_Frame_Shift_Del_p.SL2467fs			Q03001	DYST_HUMAN	dystonin	2467					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCACACTTAAGCTACCAACTG	0.386													10	112	---	---	---	---					
KHDRBS2	202559	broad.mit.edu	37	6	62604601	62604602	+	Frame_Shift_Ins	INS	-	-	C	rs150391619	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:62604601_62604602insC	ENST00000281156.4	-	6	1026_1027	c.748_749insG	c.(748-750)accfs	p.T250fs		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	250	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		CACTGTTGGTGCCCCCCGGGCT	0.540													10	236	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75827102	75827103	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:75827102_75827103insT	ENST00000322507.8	-	47	7823_7824	c.7514_7515insA	c.(7513-7515)atcfs	p.I2505fs	COL12A1_ENST00000416123.2_Frame_Shift_Ins_p.I2505fs|COL12A1_ENST00000483888.2_Frame_Shift_Ins_p.I2505fs|COL12A1_ENST00000345356.6_Frame_Shift_Ins_p.I1341fs	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2505	Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACTTACTTGAAGTGGCAGTTTC	0.381													15	155	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75866087	75866088	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:75866087_75866088insG	ENST00000322507.8	-	15	3444_3445	c.3135_3136insC	c.(3133-3138)cccagtfs	p.S1046fs	COL12A1_ENST00000416123.2_Frame_Shift_Ins_p.S1046fs|COL12A1_ENST00000483888.2_Frame_Shift_Ins_p.S1046fs|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1046	Fibronectin type-III 7.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.T1046fs*7(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GAAGTGACTGTGGGGGGCACCT	0.490													10	245	---	---	---	---					
HTR1E	3354	broad.mit.edu	37	6	87725846	87725847	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:87725846_87725847insC	ENST00000305344.4	+	2	1497_1498	c.794_795insC	c.(793-795)accfs	p.T265fs	HTR1E_ENST00000369584.1_Frame_Shift_Ins_p.T265fs	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	265					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity	p.F268fs*4(1)		breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCCATCAGGATCCCCCCCTTCG	0.510													25	1104	---	---	---	---					
SCML4	256380	broad.mit.edu	37	6	108076790	108076791	+	Frame_Shift_Ins	INS	-	-	G	rs75302347		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:108076790_108076791insG	ENST00000369021.3	-	1	52_53	c.53_54insC	c.(52-54)cttfs	p.L18fs	SCML4_ENST00000369020.3_Intron|SCML4_ENST00000369022.2_Intron			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		TCCAGTGGAATGGGGGGGTTCT	0.480													11	159	---	---	---	---					
REV3L	5980	broad.mit.edu	37	6	111693903	111693904	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:111693903_111693904insG	ENST00000435970.1	-	15	6236_6237	c.5420_5421insC	c.(5419-5421)cagfs	p.Q1807fs	REV3L_ENST00000358835.3_Frame_Shift_Ins_p.Q1885fs|REV3L_ENST00000368802.3_Frame_Shift_Ins_p.Q1885fs|REV3L_ENST00000368805.1_Frame_Shift_Ins_p.Q1885fs			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1885					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTCCCTACTTGGGGGGGACAT	0.431								DNA polymerases (catalytic subunits)					31	596	---	---	---	---					
TSPYL1	7259	broad.mit.edu	37	6	116600787	116600788	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:116600787_116600788insC	ENST00000368608.3	-	1	278_279	c.206_207insG	c.(205-207)ggtfs	p.G69fs	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	69					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CCTGGGGTACGCCCCCCTCCTC	0.703													7	346	---	---	---	---					
RFX6	222546	broad.mit.edu	37	6	117250016	117250017	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:117250016_117250017insC	ENST00000332958.2	+	18	2509_2510	c.2493_2494insC	c.(2491-2496)ctccccfs	p.LP831fs		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	831					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TTCGTTCACTGCCCCCCTACAG	0.455													16	848	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127767595	127767596	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:127767595_127767596insC	ENST00000483725.3	-	5	2204_2205	c.1868_1869insG	c.(1867-1869)gcafs	p.A623fs	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	623							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TCACTTCCTGTCCCCCCCACAC	0.401													10	223	---	---	---	---					
PTPRK	5796	broad.mit.edu	37	6	128388793	128388794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:128388793_128388794insG	ENST00000368227.3	-	12	2393_2394	c.2027_2028insC	c.(2026-2028)cggfs	p.R676fs	PTPRK_ENST00000532331.1_Frame_Shift_Ins_p.R676fs|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Frame_Shift_Ins_p.R676fs|PTPRK_ENST00000368210.3_Frame_Shift_Ins_p.R676fs|PTPRK_ENST00000368226.4_Frame_Shift_Ins_p.R676fs|PTPRK_ENST00000368207.3_Frame_Shift_Ins_p.R676fs|RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000368215.3_Frame_Shift_Ins_p.R676fs			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	676	Fibronectin type-III 4.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GTAGGTTTCCCGGGGGGAGTTC	0.545													9	280	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129419357	129419358	+	Frame_Shift_Ins	INS	-	-	C	rs143680577	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:129419357_129419358insC	ENST00000421865.2	+	4	485_486	c.436_437insC	c.(436-438)cccfs	p.P146fs		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	146	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGCAGCTAACTCCCCCCGGCCT	0.446													8	174	---	---	---	---					
CTGF	1490	broad.mit.edu	37	6	132270567	132270568	+	Frame_Shift_Ins	INS	-	-	G	rs15960		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:132270567_132270568insG	ENST00000367976.3	-	5	1086_1087	c.886_887insC	c.(886-888)cagfs	p.Q296fs		NM_001901.2	NP_001892.1	P29279	CTGF_HUMAN	connective tissue growth factor	296	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	13	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		GGTGGTTCTGTGGGGGGTGCAG	0.530													19	967	---	---	---	---					
TCF21	6943	broad.mit.edu	37	6	134210862	134210863	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:134210862_134210863insC	ENST00000367882.4	+	1	587_588	c.327_328insC	c.(325-330)gtccccfs	p.VP109fs	RP3-323P13.2_ENST00000607573.1_RNA|TCF21_ENST00000237316.3_Frame_Shift_Ins_p.VP109fs	NM_003206.3	NP_003197.2	O43680	TCF21_HUMAN	transcription factor 21	109	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	13	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		TGCCCTGGGTGCCCCCCGACAC	0.644													8	347	---	---	---	---					
SHPRH	257218	broad.mit.edu	37	6	146264758	146264759	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:146264758_146264759insT	ENST00000367503.3	-	9	2156_2157	c.1758_1759insA	c.(1756-1761)aagaaafs	p.K587fs	SHPRH_ENST00000367505.2_Frame_Shift_Ins_p.K587fs|SHPRH_ENST00000438092.2_Frame_Shift_Ins_p.K587fs|SHPRH_ENST00000275233.7_Frame_Shift_Ins_p.K587fs	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	587					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGACTTTTTCCTTTTTTTGTGG	0.371													9	374	---	---	---	---					
NOX3	50508	broad.mit.edu	37	6	155743925	155743926	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr6:155743925_155743926delCA	ENST00000159060.2	-	10	1312_1313	c.1210_1211delTG	c.(1210-1212)cfs	p.C404fs		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	404							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CGCGGCAACGCACACACACACT	0.530													11	930	---	---	---	---					
PRKAR1B	5575	broad.mit.edu	37	7	720280	720281	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:720280_720281insG	ENST00000406797.1	-	3	434_435	c.260_261insC	c.(259-261)caafs	p.Q87fs	PRKAR1B_ENST00000544935.1_Frame_Shift_Ins_p.Q87fs|PRKAR1B_ENST00000360274.4_Frame_Shift_Ins_p.Q87fs|PRKAR1B_ENST00000403562.1_Frame_Shift_Ins_p.Q87fs|PRKAR1B_ENST00000537384.1_Frame_Shift_Ins_p.Q87fs	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	87	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		CCACAGGGTTCGGGGGGGTGGG	0.619													8	88	---	---	---	---					
EIF3B	8662	broad.mit.edu	37	7	2404085	2404086	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:2404085_2404086insG	ENST00000360876.4	+	6	1134_1135	c.1078_1079insG	c.(1078-1080)gggfs	p.G360fs	EIF3B_ENST00000397011.2_Frame_Shift_Ins_p.G360fs	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	360	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CATTGCTCTATGGGGGGGAGAG	0.475													12	163	---	---	---	---					
ETV1	2115	broad.mit.edu	37	7	13975472	13975473	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:13975472_13975473insG	ENST00000343495.5	-	7	1098_1099	c.360_361insC	c.(358-363)cccaccfs	p.T121fs	ETV1_ENST00000403685.1_Frame_Shift_Ins_p.T121fs|ETV1_ENST00000399357.3_Intron|ETV1_ENST00000405192.2_Frame_Shift_Ins_p.T139fs|ETV1_ENST00000420159.2_Frame_Shift_Ins_p.T81fs|ETV1_ENST00000476720.2_5'UTR|ETV1_ENST00000405358.4_Frame_Shift_Ins_p.T153fs|ETV1_ENST00000430479.1_Frame_Shift_Ins_p.T139fs|ETV1_ENST00000403527.1_Frame_Shift_Ins_p.T99fs|ETV1_ENST00000242066.5_Frame_Shift_Ins_p.T121fs|ETV1_ENST00000405218.2_Frame_Shift_Ins_p.T139fs			P50549	ETV1_HUMAN	ets variant 1	139					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						CTGGATGGTGTGGGGGGGTTGG	0.530			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								13	359	---	---	---	---					
GPNMB	10457	broad.mit.edu	37	7	23306134	23306135	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:23306134_23306135insT	ENST00000381990.2	+	7	1214_1215	c.1053_1054insT	c.(1051-1056)ccgaccfs	p.T352fs	GPNMB_ENST00000453162.2_Frame_Shift_Ins_p.T294fs|GPNMB_ENST00000258733.4_Splice_Site|GPNMB_ENST00000539136.1_Splice_Site	NM_001005340.1|NM_002510.2	NP_001005340.1|NP_002501.1	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	352					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			CAAACACCCCAGGACCTGCTGG	0.386													7	108	---	---	---	---					
HOXA9	3205	broad.mit.edu	37	7	27203289	27203289	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:27203289delT	ENST00000343483.6	-	2	824	c.752delA	c.(751-753)agfs	p.K251fs	RP1-170O19.20_ENST00000470747.4_Frame_Shift_Del_p.K91fs|RP1-170O19.20_ENST00000465941.1_5'UTR|HOXA9_ENST00000396345.1_3'UTR|HOXA9_ENST00000497089.1_5'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	251							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						GAACCAGATCTTGACCTGCCT	0.483			T	"""NUP98, MSI2"""	AML*								7	495	---	---	---	---					
NEUROD6	63974	broad.mit.edu	37	7	31378634	31378635	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:31378634_31378635insT	ENST00000297142.3	-	2	570_571	c.248_249insA	c.(247-249)aacfs	p.N83fs		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	83					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTTTGTTGTCTTTTTTTTCCT	0.520													8	1100	---	---	---	---					
FKBP9	11328	broad.mit.edu	37	7	33014803	33014804	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:33014803_33014804insC	ENST00000242209.4	+	3	546_547	c.377_378insC	c.(376-378)accfs	p.T126fs	FKBP9_ENST00000538443.1_5'UTR|FKBP9_ENST00000538336.1_Frame_Shift_Ins_p.T179fs|AVL9_ENST00000404479.1_Intron	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	126	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GCTGGTGTGATCCCCCCCAATT	0.446													10	223	---	---	---	---					
EPDR1	54749	broad.mit.edu	37	7	37988587	37988588	+	Frame_Shift_Ins	INS	-	-	T	rs145911941	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:37988587_37988588insT	ENST00000199448.4	+	2	794_795	c.415_416insT	c.(415-417)cggfs	p.R139fs	EPDR1_ENST00000425345.1_Frame_Shift_Ins_p.R78fs|EPDR1_ENST00000559325.1_Frame_Shift_Ins_p.R259fs|EPDR1_ENST00000423717.1_Intron|EPDR1_ENST00000476620.1_Frame_Shift_Ins_p.R37fs	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	139					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						CCAGTACTCCATCGGGGGGCCT	0.510													13	592	---	---	---	---					
NSUN5P1	155400	broad.mit.edu	37	7	75045496	75045497	+	RNA	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:75045496_75045497insG	ENST00000393633.2	+	0	4280																				large_intestine(1)|lung(1)	2						AGGGTCGTGGAGGGGGGGGATG	0.653													7	87	---	---	---	---					
GRM3	2913	broad.mit.edu	37	7	86415681	86415682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:86415681_86415682insC	ENST00000361669.2	+	3	1672_1673	c.573_574insC	c.(571-576)gtccccfs	p.VP191fs	GRM3_ENST00000394720.2_Frame_Shift_Ins_p.VP189fs|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Frame_Shift_Ins_p.VP63fs|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000439827.1_Frame_Shift_Ins_p.VP191fs	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	191					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAGGACCGTGCCCCCCGACTT	0.564													10	263	---	---	---	---					
TRRAP	8295	broad.mit.edu	37	7	98592294	98592295	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:98592294_98592295insC	ENST00000359863.4	+	66	10299_10300	c.10090_10091insC	c.(10090-10092)cccfs	p.P3364fs	TRRAP_ENST00000355540.3_Frame_Shift_Ins_p.P3335fs|TRRAP_ENST00000446306.3_Frame_Shift_Ins_p.P3353fs	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3364					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTAAAATCACCCCCCACACT	0.540													12	641	---	---	---	---					
TRRAP	8295	broad.mit.edu	37	7	98609744	98609745	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:98609744_98609745insA	ENST00000359863.4	+	72	11555_11556	c.11346_11347insA	c.(11344-11349)caaaaafs	p.QK3782fs	TRRAP_ENST00000355540.3_Frame_Shift_Ins_p.QK3753fs|TRRAP_ENST00000446306.3_Frame_Shift_Ins_p.QK3771fs	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3782	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTGCTTGGCACAAAAAAACACA	0.550													7	635	---	---	---	---					
GAL3ST4	79690	broad.mit.edu	37	7	99757596	99757597	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:99757596_99757597insG	ENST00000360039.4	-	4	1807_1808	c.1415_1416insC	c.(1414-1416)cacfs	p.H472fs	GAL3ST4_ENST00000423751.1_3'UTR|GAL3ST4_ENST00000413800.1_Frame_Shift_Ins_p.H472fs|GAL3ST4_ENST00000426974.2_Frame_Shift_Ins_p.H410fs|GAL3ST4_ENST00000411994.1_3'UTR	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	472					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGAGACGGTAGGGGGGAACTG	0.540													8	660	---	---	---	---					
SPDYE3	441272	broad.mit.edu	37	7	99912173	99912174	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:99912173_99912174insC	ENST00000332397.6	+	6	1185_1186	c.1001_1002insC	c.(1000-1002)accfs	p.T334fs	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	334										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						GTAGATCCCAGCCCCCCGCGTA	0.569													11	277	---	---	---	---					
PCOLCE	5118	broad.mit.edu	37	7	100205413	100205414	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100205413_100205414insC	ENST00000223061.5	+	8	1446_1447	c.1166_1167insC	c.(1165-1167)tccfs	p.S389fs		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	389	NTR.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity	p.M392fs*>59(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGCAAGCAGTGCCCCCCCATGA	0.510													24	316	---	---	---	---					
EPHB4	2050	broad.mit.edu	37	7	100404119	100404120	+	Frame_Shift_Ins	INS	-	-	CTGA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100404119_100404120insCTGA	ENST00000358173.3	-	14	2874_2875	c.2406_2407insTCAG	c.(2404-2409)gacctgfs	p.L803fs	EPHB4_ENST00000360620.3_Frame_Shift_Ins_p.L803fs	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	803	Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TAACTCCAGGCATCACTGGCGG	0.554													33	994	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100479331	100479332	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100479331_100479332insG	ENST00000388793.4	+	4	523_524	c.303_304insG	c.(301-306)gcggggfs	p.AG101fs	SRRT_ENST00000347433.4_Frame_Shift_Ins_p.AG101fs|SRRT_ENST00000432932.1_Frame_Shift_Ins_p.AG101fs|SRRT_ENST00000457580.2_Frame_Shift_Ins_p.AG101fs	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	101					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding	p.G104fs*45(1)		breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TGCCCTATGCTGGGGGGGGTGG	0.609													19	156	---	---	---	---					
AP1S1	1174	broad.mit.edu	37	7	100802404	100802405	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100802404_100802405insG	ENST00000337619.5	+	4	474_475	c.356_357insG	c.(355-357)aggfs	p.R119fs		NM_001283.3	NP_001274.1	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1 subunit	119					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)	8	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGTTTTTGATGGGGGGGGATG	0.564													14	150	---	---	---	---					
NAT16	375607	broad.mit.edu	37	7	100817873	100817874	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100817873_100817874insC	ENST00000300303.2	-	2	453_454	c.215_216insG	c.(214-216)gatfs	p.D72fs	NAT16_ENST00000443096.1_Frame_Shift_Ins_p.D72fs|NAT16_ENST00000455377.1_Frame_Shift_Ins_p.D72fs	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	72	N-acetyltransferase.						N-acetyltransferase activity										CGCCGTAGATGCCCCCCGAGAT	0.678													7	133	---	---	---	---					
PLOD3	8985	broad.mit.edu	37	7	100856125	100856126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:100856125_100856126insC	ENST00000223127.3	-	8	1274_1275	c.876_877insG	c.(874-879)ggagccfs	p.A293fs		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	293					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CACCTCACCTGCCCCCCCGGGA	0.673													13	120	---	---	---	---					
LAMB1	3912	broad.mit.edu	37	7	107572729	107572730	+	Frame_Shift_Ins	INS	-	-	C	rs57244800	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:107572729_107572730insC	ENST00000393561.1	-	26	4537_4538	c.4353_4354insG	c.(4351-4356)ggctggfs	p.W1452fs	LAMB1_ENST00000222399.6_Frame_Shift_Ins_p.W1428fs|LAMB1_ENST00000474380.1_5'UTR			P07942	LAMB1_HUMAN	laminin, beta 1	1428	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACAGCCAGGCCCCCCACACT	0.584													11	386	---	---	---	---					
DOCK4	9732	broad.mit.edu	37	7	111418424	111418425	+	Splice_Site	INS	-	-	GA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:111418424_111418425insGA	ENST00000428084.1	-	36	3858_3859	c.3585_splice	c.e36-1	p.L1196_splice	DOCK4_ENST00000437633.1_Splice_Site_p.L1187_splice|DOCK4_ENST00000494651.2_Splice_Site_p.L70_splice			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1187	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CTTATAGAAGTTCTGTAAAAAA	0.381													14	220	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131195812	131195813	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:131195812_131195813insC	ENST00000541194.1	-	2	743_744	c.486_487insG	c.(484-489)ggaaagfs	p.GK162fs	PODXL_ENST00000378555.3_Frame_Shift_Ins_p.GK160fs|PODXL_ENST00000322985.9_Frame_Shift_Ins_p.GK160fs|PODXL_ENST00000537928.1_Frame_Shift_Ins_p.GK160fs	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	160	Thr-rich.				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.K161E(1)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					TGGCTGCTTTTCCCCCCAGAGT	0.525													7	542	---	---	---	---					
KEL	3792	broad.mit.edu	37	7	142639979	142639980	+	Frame_Shift_Ins	INS	-	-	C	rs140258059		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:142639979_142639980insC	ENST00000355265.2	-	17	2397_2398	c.1923_1924insG	c.(1921-1926)ggtagcfs	p.S642fs		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	642					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCGATGGCTAGCCCCCCAACGT	0.500													17	950	---	---	---	---					
OR2A25	392138	broad.mit.edu	37	7	143771314	143771315	+	Translation_Start_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:143771314_143771315insG	ENST00000408898.2	+	0	40_41					NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TACAGGGAAATGGGGGGAAATC	0.441													9	209	---	---	---	---					
AGAP3	116988	broad.mit.edu	37	7	150814456	150814457	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr7:150814456_150814457insG	ENST00000397238.2	+	4	478		c.e4-1		AGAP3_ENST00000335367.3_Splice_Site|AGAP3_ENST00000476375.1_Splice_Site|AGAP3_ENST00000479901.1_Splice_Site|AGAP3_ENST00000463381.1_Splice_Site|AGAP3_ENST00000473312.1_Splice_Site	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						GCTCTGTCCTAGGGGGGCGGTT	0.579													9	390	---	---	---	---					
MYOM2	9172	broad.mit.edu	37	8	2088682	2088683	+	Frame_Shift_Ins	INS	-	-	G	rs34620424	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:2088682_2088683insG	ENST00000262113.4	+	33	3978_3979	c.3837_3838insG	c.(3835-3840)atggggfs	p.MG1279fs	MYOM2_ENST00000523438.1_Frame_Shift_Ins_p.MG704fs|MYOM2_ENST00000520298.1_3'UTR	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1279					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ATATGAGAATCGGGGGGAGTGA	0.446													13	668	---	---	---	---					
DLC1	10395	broad.mit.edu	37	8	12957611	12957613	+	In_Frame_Del	DEL	GCT	GCT	-	rs137989738		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:12957611_12957613delGCT	ENST00000276297.4	-	9	2642_2644	c.2233_2235delAGC	c.(2233-2235)del	p.S745del	DLC1_ENST00000520226.1_In_Frame_Del_p.S234del|DLC1_ENST00000512044.2_In_Frame_Del_p.S342del|DLC1_ENST00000358919.2_In_Frame_Del_p.S308del	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	745	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TCTCCGACTGGCTGCTGCTGCTG	0.621													8	431	---	---	---	---					
SLC18A1	6570	broad.mit.edu	37	8	20004787	20004788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:20004787_20004788insG	ENST00000440926.1	-	16	1915_1916	c.1445_1446insC	c.(1444-1446)cgcfs	p.R482fs	SLC18A1_ENST00000381608.4_Intron|SLC18A1_ENST00000519026.1_Frame_Shift_Ins_p.R450fs|SLC18A1_ENST00000437980.1_Intron|SLC18A1_ENST00000265808.7_Frame_Shift_Ins_p.R450fs|SLC18A1_ENST00000276373.5_Frame_Shift_Ins_p.R482fs	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	482					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CTTCCTTTGCCGGGGGGCTCCG	0.500													12	610	---	---	---	---					
SORBS3	10174	broad.mit.edu	37	8	22414410	22414411	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:22414410_22414411insC	ENST00000240123.7	+	4	786_787	c.403_404insC	c.(403-405)cccfs	p.P135fs	SORBS3_ENST00000523402.1_Frame_Shift_Ins_p.P135fs	NM_005775.4	NP_005766.3	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3	135	SoHo.				muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)	18		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CATGCCCATTGCCCCCCGATCC	0.634													12	421	---	---	---	---					
DPYSL2	1808	broad.mit.edu	37	8	26513183	26513184	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:26513183_26513184insC	ENST00000311151.5	+	14	2092_2093	c.1680_1681insC	c.(1678-1683)gcccccfs	p.AP560fs	DPYSL2_ENST00000523027.1_Frame_Shift_Ins_p.AP524fs|DPYSL2_ENST00000521913.1_Frame_Shift_Ins_p.AP524fs	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	560					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GTATCGTGGCGCCCCCCGGTGG	0.644											OREG0018659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	445	---	---	---	---					
INTS9	55756	broad.mit.edu	37	8	28633353	28633354	+	Frame_Shift_Ins	INS	-	-	G	rs148560235		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:28633353_28633354insG	ENST00000416984.2	-	13	1781_1782	c.1422_1423insC	c.(1420-1425)ccccatfs	p.H475fs	INTS9_ENST00000521777.1_Frame_Shift_Ins_p.H472fs|INTS9_ENST00000521022.1_Frame_Shift_Ins_p.H496fs|INTS9_ENST00000397363.4_Frame_Shift_Ins_p.H390fs	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	496					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		TAGGACATGGCGGGGGGCTGGC	0.619													7	301	---	---	---	---					
KAT6A	7994	broad.mit.edu	37	8	41834603	41834604	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:41834603_41834604insC	ENST00000396930.3	-	8	1828_1829	c.1285_1286insG	c.(1285-1287)agtfs	p.S429fs	KAT6A_ENST00000406337.1_Frame_Shift_Ins_p.S429fs|KAT6A_ENST00000485568.1_Frame_Shift_Ins_p.S429fs|KAT6A_ENST00000265713.2_Frame_Shift_Ins_p.S429fs	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	429	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GTCCACCACTTCCCCCCGAGCT	0.465													7	292	---	---	---	---					
KAT6A	7994	broad.mit.edu	37	8	41836183	41836184	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:41836183_41836184insT	ENST00000396930.3	-	7	1562_1563	c.1019_1020insA	c.(1018-1020)aagfs	p.K340fs	KAT6A_ENST00000406337.1_Frame_Shift_Ins_p.K340fs|KAT6A_ENST00000485568.1_Frame_Shift_Ins_p.K340fs|KAT6A_ENST00000265713.2_Frame_Shift_Ins_p.K340fs	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	340	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCTTTAACCTGTTTTTTGGACG	0.401													9	629	---	---	---	---					
POMK	84197	broad.mit.edu	37	8	42958728	42958729	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:42958728_42958729insC	ENST00000331373.5	+	4	292_293	c.37_38insC	c.(37-39)cccfs	p.P13fs		NM_001277971.1|NM_032237.3	NP_001264900.1|NP_115613.1	Q9H5K3	SG196_HUMAN		13						integral to membrane	ATP binding|protein kinase activity										GAGAGGCCTCGCCCCCCGAGAG	0.540													10	136	---	---	---	---					
PLAG1	5324	broad.mit.edu	37	8	57078931	57078932	+	Frame_Shift_Ins	INS	-	-	G	rs144552372		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:57078931_57078932insG	ENST00000316981.3	-	5	1852_1853	c.1373_1374insC	c.(1372-1374)ccafs	p.P458fs	PLAG1_ENST00000423799.2_Frame_Shift_Ins_p.P376fs|PLAG1_ENST00000429357.2_Frame_Shift_Ins_p.P458fs	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	458	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.		P -> T (in dbSNP:rs35883156).			nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CCTGTGTTTGTGGGGGGAGCTG	0.490			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								13	450	---	---	---	---					
ARFGEF1	10565	broad.mit.edu	37	8	68128855	68128856	+	Frame_Shift_Ins	INS	-	-	G	rs142098461		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:68128855_68128856insG	ENST00000262215.3	-	33	5044_5045	c.4655_4656insC	c.(4654-4656)cccfs	p.P1552fs	ARFGEF1_ENST00000520381.1_Frame_Shift_Ins_p.P1006fs|ARFGEF1_ENST00000518230.1_Frame_Shift_Ins_p.P390fs	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1552					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAGATGGAGGTGGGGGGGCAGT	0.421													7	143	---	---	---	---					
SULF1	23213	broad.mit.edu	37	8	70488248	70488249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:70488248_70488249insG	ENST00000260128.4	+	6	933_934	c.216_217insG	c.(214-219)caggggfs	p.QG72fs	SULF1_ENST00000402687.4_Frame_Shift_Ins_p.QG72fs|SULF1_ENST00000458141.2_Frame_Shift_Ins_p.QG72fs|SULF1_ENST00000419716.3_Frame_Shift_Ins_p.QG72fs	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	72					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTATGGAACATGGGGGGGCCAC	0.495													12	130	---	---	---	---					
JPH1	56704	broad.mit.edu	37	8	75156987	75156988	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:75156987_75156988insG	ENST00000342232.4	-	4	1721_1722	c.1681_1682insC	c.(1681-1683)gcafs	p.A561fs	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	561					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TGGAGGGTGCTGGGGGGCGTTC	0.594													8	165	---	---	---	---					
SLC26A7	115111	broad.mit.edu	37	8	92261931	92261932	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:92261931_92261932insC	ENST00000276609.3	+	2	291_292	c.52_53insC	c.(52-54)cccfs	p.P18fs	SLC26A7_ENST00000309536.2_Frame_Shift_Ins_p.P18fs|SLC26A7_ENST00000523719.1_Frame_Shift_Ins_p.P18fs	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	18						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CAAGATGCATACCCCCCAGTGT	0.396													7	256	---	---	---	---					
POP1	10940	broad.mit.edu	37	8	99168467	99168468	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:99168467_99168468insA	ENST00000401707.2	+	15	2328_2329	c.2247_2248insA	c.(2245-2250)ccaaaafs	p.PK749fs	POP1_ENST00000349693.3_Frame_Shift_Ins_p.PK749fs	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	749					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CTCCCATGCCTAAAAAAACTCA	0.510													8	961	---	---	---	---					
PABPC1	26986	broad.mit.edu	37	8	101724994	101724995	+	Frame_Shift_Ins	INS	-	-	A	rs140822921	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:101724994_101724995insA	ENST00000318607.5	-	6	1889_1890	c.761_762insT	c.(760-762)agafs	p.R254fs	PABPC1_ENST00000522387.1_Frame_Shift_Ins_p.R222fs|PABPC1_ENST00000519596.1_5'UTR|PABPC1_ENST00000519004.1_Frame_Shift_Ins_p.R209fs	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	254	CSDE1-binding.|RRM 3.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CATTGAGCTCCTTTCCGTTCAT	0.371													11	132	---	---	---	---					
MTBP	27085	broad.mit.edu	37	8	121457738	121457739	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:121457738_121457739insG	ENST00000305949.1	+	1	73_74	c.28_29insG	c.(28-30)gggfs	p.G10fs		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	10					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GCTGGTGATCTGGGGGGAAGGA	0.589													9	246	---	---	---	---					
MIR1208	100302281	broad.mit.edu	37	8	129162432	129162433	+	RNA	INS	-	-	G	rs2648841	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:129162432_129162433insG	ENST00000408334.1	+	0	71_72					NR_031613.1																						ACCACTGTGGTGGGGGGGAGTG	0.564													8	221	---	---	---	---					
ASAP1	50807	broad.mit.edu	37	8	131124498	131124499	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr8:131124498_131124499insG	ENST00000357668.1	-	23	2269_2270	c.2242_2243insC	c.(2242-2244)ggafs	p.G748fs	ASAP1_ENST00000518721.1_Frame_Shift_Ins_p.G748fs			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	748					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CAGCTTGTCCTGGGGGGAGATG	0.535													8	379	---	---	---	---					
KANK1	23189	broad.mit.edu	37	9	732475	732477	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:732475_732477delGAG	ENST00000382303.1	+	10	3755_3757	c.3103_3105delGAG	c.(3103-3105)del	p.E1039del	KANK1_ENST00000382293.3_In_Frame_Del_p.E881del|KANK1_ENST00000382297.2_In_Frame_Del_p.E1039del|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1039					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TCTTGAAGAAGAGGAGGAGGAGG	0.463													10	1330	---	---	---	---					
FREM1	158326	broad.mit.edu	37	9	14823286	14823287	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:14823286_14823287insG	ENST00000380881.4	-	14	3026_3027	c.2211_2212insC	c.(2209-2214)cctgcafs	p.A738fs	FREM1_ENST00000422223.2_Frame_Shift_Ins_p.A737fs|FREM1_ENST00000380880.3_Frame_Shift_Ins_p.A737fs			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	737					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGTCTTGCATGGGGGGCATGT	0.441													20	1547	---	---	---	---					
BNC2	54796	broad.mit.edu	37	9	16436374	16436375	+	Frame_Shift_Ins	INS	-	-	G	rs116528562	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:16436374_16436375insG	ENST00000380672.4	-	6	1874_1875	c.1817_1818insC	c.(1816-1818)cccfs	p.P606fs	BNC2_ENST00000380666.2_Frame_Shift_Ins_p.P606fs|BNC2_ENST00000380667.2_Frame_Shift_Ins_p.P539fs|BNC2_ENST00000545497.1_Frame_Shift_Ins_p.P511fs	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	606	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CAGAGGGTGGCGGGGGGTGCTG	0.564													11	642	---	---	---	---					
TEK	7010	broad.mit.edu	37	9	27172694	27172695	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:27172694_27172695delAC	ENST00000380036.4	+	5	1151_1152	c.709_710delAC	c.(709-711)tfs	p.T237fs	TEK_ENST00000406359.4_Frame_Shift_Del_p.T237fs|TEK_ENST00000519097.1_Frame_Shift_Del_p.T133fs	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	237	EGF-like 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CCATGAAGATACTGGAGAATGC	0.436													22	178	---	---	---	---					
FAM219A	203259	broad.mit.edu	37	9	34401027	34401028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:34401027_34401028insG	ENST00000445726.1	-	6	798_799	c.492_493insC	c.(490-495)ccagtcfs	p.V165fs	FAM219A_ENST00000379080.1_Frame_Shift_Ins_p.V152fs|FAM219A_ENST00000297620.4_Frame_Shift_Ins_p.V148fs|FAM219A_ENST00000379089.1_Frame_Shift_Ins_p.V163fs|FAM219A_ENST00000379084.1_Splice_Site_p.P147_splice|FAM219A_ENST00000379087.1_Frame_Shift_Ins_p.V146fs|FAM219A_ENST00000379081.1_Frame_Shift_Ins_p.V136fs	NM_001184940.1|NM_001184941.1	NP_001171869.1|NP_001171870.1	Q8IW50	CI025_HUMAN	family with sequence similarity 219, member A	165																	TTCACGGACTTGGGGGGGATGA	0.644													7	122	---	---	---	---					
PIGO	84720	broad.mit.edu	37	9	35091522	35091523	+	Frame_Shift_Ins	INS	-	-	G	rs144233446		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:35091522_35091523insG	ENST00000378617.3	-	7	2755_2756	c.2361_2362insC	c.(2359-2364)cccttcfs	p.F788fs	PIGO_ENST00000298004.5_Intron|PIGO_ENST00000341666.3_Frame_Shift_Ins_p.F788fs|PIGO_ENST00000361778.2_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	788					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity	p.T788fs*5(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTTGAGAAGTGGGGGGGCCTG	0.604													12	231	---	---	---	---					
NPR2	4882	broad.mit.edu	37	9	35809224	35809225	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:35809224_35809225insG	ENST00000342694.2	+	21	3313_3314	c.3058_3059insG	c.(3058-3060)gggfs	p.G1020fs	SPAG8_ENST00000340291.2_Intron	NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	1020					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GCTAGAGCTTCGGGGGGATGTG	0.559													10	407	---	---	---	---					
SPAG8	26206	broad.mit.edu	37	9	35809952	35809953	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:35809952_35809953insC	ENST00000484764.1	-	7	1456_1457	c.1416_1417insG	c.(1414-1419)gggaatfs	p.N473fs	SPAG8_ENST00000340291.2_Intron|SPAG8_ENST00000479751.1_5'UTR|SPAG8_ENST00000396638.2_Frame_Shift_Ins_p.N481fs			Q99932	SPAG8_HUMAN	sperm associated antigen 8	0						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GGAGTCATTCTCCCCCCTCCAC	0.505													9	555	---	---	---	---					
GLIPR2	152007	broad.mit.edu	37	9	36147846	36147847	+	Frame_Shift_Ins	INS	-	-	C	rs60088684	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:36147846_36147847insC	ENST00000377960.4	+	2	111_112	c.77_78insC	c.(76-78)gccfs	p.A26fs	GLIPR2_ENST00000396613.3_3'UTR|GLIPR2_ENST00000474050.1_3'UTR|GLIPR2_ENST00000377959.1_Frame_Shift_Ins_p.A26fs	NM_022343.2	NP_071738.1	Q9H4G4	GAPR1_HUMAN	GLI pathogenesis-related 2	26						extracellular region|Golgi membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(3)	10						AAGCACGGCGTCCCCCCACTGA	0.540													9	603	---	---	---	---					
RNF38	152006	broad.mit.edu	37	9	36353239	36353240	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:36353239_36353240insG	ENST00000357058.3	-	7	1355_1356	c.749_750insC	c.(748-750)cacfs	p.H250fs	RNF38_ENST00000377885.2_Frame_Shift_Ins_p.H250fs|RNF38_ENST00000350199.4_Frame_Shift_Ins_p.H250fs|RNF38_ENST00000259605.6_Frame_Shift_Ins_p.H333fs|RNF38_ENST00000377877.4_Frame_Shift_Ins_p.H257fs|RNF38_ENST00000353739.4_Frame_Shift_Ins_p.H283fs	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	333	Pro-rich.						zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			GAGGTAATGTTGGGGGGTGGGC	0.460													9	398	---	---	---	---					
APBA1	320	broad.mit.edu	37	9	72047492	72047493	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:72047492_72047493insG	ENST00000265381.4	-	12	2623_2624	c.2401_2402insC	c.(2401-2403)cgafs	p.R801fs		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	801	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GATCTTCTCGTGGGGGGTGGCC	0.624													7	302	---	---	---	---					
ANKRD19P	138649	broad.mit.edu	37	9	95649123	95649124	+	RNA	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:95649123_95649124insC	ENST00000473204.1	+	0	2259																											GCAATCTAGCACCCCCCAAAAG	0.540													9	399	---	---	---	---					
PTCH1	5727	broad.mit.edu	37	9	98209616	98209617	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:98209616_98209617insG	ENST00000430669.2	-	23	4308_4309	c.3723_3724insC	c.(3721-3726)ccgagafs	p.R1242fs	PTCH1_ENST00000375274.2_Frame_Shift_Ins_p.R1307fs|PTCH1_ENST00000437951.1_Frame_Shift_Ins_p.R1242fs|PTCH1_ENST00000331920.6_Frame_Shift_Ins_p.R1308fs|PTCH1_ENST00000429896.2_Frame_Shift_Ins_p.R1157fs|PTCH1_ENST00000418258.1_Frame_Shift_Ins_p.R1157fs|PTCH1_ENST00000421141.1_Frame_Shift_Ins_p.R1157fs			Q13635	PTC1_HUMAN	patched 1	1308			E -> K (in squamous cell carcinoma).		embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.R1308G(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAGCCTTCTCTGGGGGGGTCCC	0.663													7	74	---	---	---	---					
CCDC180	100499483	broad.mit.edu	37	9	100082417	100082418	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:100082417_100082418insC	ENST00000375202.2	+	25	2573_2574	c.1221_1222insC	c.(1219-1224)ctccccfs	p.LP407fs	CCDC180_ENST00000357054.1_Frame_Shift_Ins_p.LP546fs|CCDC180_ENST00000460482.2_3'UTR|CCDC180_ENST00000529487.1_Frame_Shift_Ins_p.LP407fs|CCDC180_ENST00000395220.1_Frame_Shift_Ins_p.LP506fs|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000411667.2_Frame_Shift_Ins_p.LP404fs					coiled-coil domain containing 180																		GTGACCTCCTGCCCCCCAGTTA	0.505													16	931	---	---	---	---					
TSTD2	158427	broad.mit.edu	37	9	100389762	100389763	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:100389762_100389763insG	ENST00000341170.4	-	2	464_465	c.82_83insC	c.(82-84)gagfs	p.E28fs	TSTD2_ENST00000375172.2_5'UTR|TSTD2_ENST00000354801.2_5'UTR	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	28										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						AATAAGACTCATATCTTTTAAA	0.376													16	331	---	---	---	---					
ABCA1	19	broad.mit.edu	37	9	107593322	107593323	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:107593322_107593323insC	ENST00000374736.3	-	14	2169_2170	c.1775_1776insG	c.(1774-1776)gttfs	p.V592fs		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	592					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTAGGCGAAGCCCCCCCAGAC	0.540													22	359	---	---	---	---					
ZNF462	58499	broad.mit.edu	37	9	109691601	109691602	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:109691601_109691602insG	ENST00000277225.5	+	3	5697_5698	c.5408_5409insG	c.(5407-5409)tggfs	p.W1803fs	ZNF462_ENST00000457913.1_Frame_Shift_Ins_p.W1803fs|ZNF462_ENST00000441147.2_Frame_Shift_Ins_p.W648fs			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1803					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GCCAGCAAGTTGGGGGGCTACT	0.550													10	647	---	---	---	---					
PAPPA	5069	broad.mit.edu	37	9	118982329	118982330	+	Frame_Shift_Ins	INS	-	-	C	rs34371232	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:118982329_118982330insC	ENST00000328252.3	+	5	2401_2402	c.2032_2033insC	c.(2032-2034)cccfs	p.P678fs	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	678					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGTTGCCCTCGCCCCCCAAGTT	0.574													18	635	---	---	---	---					
CDK5RAP2	55755	broad.mit.edu	37	9	123169393	123169394	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:123169393_123169394delCT	ENST00000349780.4	-	32	5038_5039	c.4859_4860delAG	c.(4858-4860)afs	p.K1620fs	CDK5RAP2_ENST00000359309.3_Frame_Shift_Del_p.K1579fs|CDK5RAP2_ENST00000360190.4_Intron|CDK5RAP2_ENST00000360822.3_Frame_Shift_Del_p.K1588fs	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1620					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CCAGCTGTTCCTTGAGCCTGCT	0.594													37	682	---	---	---	---					
RAPGEF1	2889	broad.mit.edu	37	9	134504526	134504527	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr9:134504526_134504527insG	ENST00000372195.1	-	7	1098_1099	c.855_856insC	c.(853-858)ccagccfs	p.A286fs	RAPGEF1_ENST00000372189.3_Frame_Shift_Ins_p.A269fs|RAPGEF1_ENST00000481260.1_5'UTR|RAPGEF1_ENST00000372190.3_Frame_Shift_Ins_p.A287fs			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	269					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		AGAGGAGGCTTGGGGGGCGCGA	0.540													8	320	---	---	---	---					
PRKCQ	5588	broad.mit.edu	37	10	6506351	6506352	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:6506351_6506352insA	ENST00000263125.5	-	13	1467_1468	c.1368_1369insT	c.(1366-1371)tttgatfs	p.D457fs	PRKCQ_ENST00000539722.1_Frame_Shift_Ins_p.D332fs|PRKCQ_ENST00000397176.2_Frame_Shift_Ins_p.D457fs	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	457	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TACTCCATCACAAAAAAGAGGT	0.401													13	1167	---	---	---	---					
TAF3	83860	broad.mit.edu	37	10	8006928	8006929	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:8006928_8006929insC	ENST00000344293.5	+	3	1661_1662	c.1455_1456insC	c.(1453-1458)atccccfs	p.IP485fs		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	485					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTTCAAATATGCCCCCCAACTT	0.490													7	267	---	---	---	---					
PHYH	5264	broad.mit.edu	37	10	13325834	13325835	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:13325834_13325835insC	ENST00000396920.3	-	7	1036_1037	c.632_633insG	c.(631-633)ggtfs	p.G211fs	PHYH_ENST00000263038.4_Frame_Shift_Ins_p.G228fs|PHYH_ENST00000396913.2_Frame_Shift_Ins_p.G128fs			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	228					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTTTGTTAACTCCCCCCTAGAA	0.465													13	786	---	---	---	---					
FRMD4A	55691	broad.mit.edu	37	10	13696451	13696452	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:13696451_13696452insG	ENST00000357447.2	-	23	3382_3383	c.3014_3015insC	c.(3013-3015)cagfs	p.Q1005fs	FRMD4A_ENST00000358621.4_Frame_Shift_Ins_p.Q990fs|FRMD4A_ENST00000378503.1_Frame_Shift_Ins_p.Q1005fs	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	1005	Ser-rich.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GGGGGCTGCTTGGGGGGGTGGC	0.535													18	431	---	---	---	---					
YME1L1	10730	broad.mit.edu	37	10	27437919	27437920	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:27437919_27437920insT	ENST00000326799.3	-	2	231_232	c.83_84insA	c.(82-84)aacfs	p.N28fs	YME1L1_ENST00000477432.1_Frame_Shift_Ins_p.N28fs|YME1L1_ENST00000376016.3_Frame_Shift_Ins_p.N28fs|YME1L1_ENST00000375972.3_Frame_Shift_Ins_p.N28fs	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	28					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						AAACAGAAGTGTTTTTTGGTGT	0.381													8	724	---	---	---	---					
ZEB1	6935	broad.mit.edu	37	10	31809832	31809833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:31809832_31809833insG	ENST00000446923.2	+	7	1912_1913	c.1521_1522insG	c.(1519-1524)gaggggfs	p.EG507fs	ZEB1_ENST00000560721.2_Frame_Shift_Ins_p.EG503fs|ZEB1_ENST00000361642.5_Frame_Shift_Ins_p.EG524fs|ZEB1_ENST00000542815.3_Frame_Shift_Ins_p.EG456fs|ZEB1_ENST00000320985.10_Frame_Shift_Ins_p.EG523fs|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	523					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGCTTTGAAGGGGGGGTGAA	0.371													19	259	---	---	---	---					
FAM21EP	100421577	broad.mit.edu	37	10	51820739	51820740	+	RNA	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:51820739_51820740insG	ENST00000456967.1	-	0	1397					NR_038275.1																						TTGCCAATCCTGGGGGGCTTCC	0.485													7	299	---	---	---	---					
ZSWIM8	23053	broad.mit.edu	37	10	75560463	75560464	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:75560463_75560464insC	ENST00000604729.1	+	24	5365_5366	c.5068_5069insC	c.(5068-5070)cccfs	p.P1690fs	ZSWIM8_ENST00000603114.1_Frame_Shift_Ins_p.P1652fs|NDST2_ENST00000456638.1_Intron|ZSWIM8_ENST00000605216.1_Frame_Shift_Ins_p.P1693fs|ZSWIM8_ENST00000604524.1_Frame_Shift_Ins_p.P1511fs|ZSWIM8_ENST00000398706.2_Frame_Shift_Ins_p.P1698fs					zinc finger, SWIM-type containing 8																		CTTCTCCCGCTCCCCCCCCTAC	0.604													13	146	---	---	---	---					
ZFYVE27	118813	broad.mit.edu	37	10	99504492	99504499	+	Frame_Shift_Del	DEL	GGTACTCA	GGTACTCA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:99504492_99504499delGGTACTCA	ENST00000393677.4	+	4	479_486	c.275_282delGGTACTCA	c.(274-282)tfs	p.WYS92fs	ZFYVE27_ENST00000453958.2_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000359980.3_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000370613.3_Intron|ZFYVE27_ENST00000370610.3_5'UTR|ZFYVE27_ENST00000356257.4_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000357540.4_Intron|ZFYVE27_ENST00000337540.7_Frame_Shift_Del_p.WYS60fs	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	92					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		GCAGGTGCATGGTACTCAGTAGGTGCCC	0.577													8	134	---	---	---	---					
ZFYVE27	118813	broad.mit.edu	37	10	99510176	99510177	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:99510176_99510177insG	ENST00000393677.4	+	7	957_958	c.753_754insG	c.(751-756)gtggggfs	p.VG251fs	ZFYVE27_ENST00000453958.2_Frame_Shift_Ins_p.VG251fs|ZFYVE27_ENST00000359980.3_Frame_Shift_Ins_p.VG251fs|ZFYVE27_ENST00000370613.3_Frame_Shift_Ins_p.VG133fs|ZFYVE27_ENST00000370610.3_Frame_Shift_Ins_p.VG153fs|ZFYVE27_ENST00000356257.4_Frame_Shift_Ins_p.VG251fs|ZFYVE27_ENST00000357540.4_Frame_Shift_Ins_p.VG165fs|ZFYVE27_ENST00000337540.7_Frame_Shift_Ins_p.VG219fs	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	251					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CACCAGATGTTGGGGGGAAGGA	0.599													26	1220	---	---	---	---					
HPS1	3257	broad.mit.edu	37	10	100189562	100189563	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:100189562_100189563insC	ENST00000325103.6	-	9	1085_1086	c.852_853insG	c.(850-855)gggctcfs	p.L285fs	HPS1_ENST00000338546.5_Frame_Shift_Ins_p.L285fs|HPS1_ENST00000361490.4_Frame_Shift_Ins_p.L285fs|HPS1_ENST00000467246.1_Intron	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	285					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		TCTGCAGAGCTCCCCCCAGTTG	0.688									Hermansky-Pudlak syndrome				10	595	---	---	---	---					
CPN1	1369	broad.mit.edu	37	10	101816832	101816833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:101816832_101816833insG	ENST00000370418.3	-	6	1199_1200	c.948_949insC	c.(946-951)ccaagafs	p.R317fs		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	317	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		AACTCCTCTTCGGGGGGAAACT	0.470													17	903	---	---	---	---					
SEC31B	25956	broad.mit.edu	37	10	102265153	102265154	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:102265153_102265154insG	ENST00000370345.3	-	10	1240_1241	c.1143_1144insC	c.(1141-1146)ccaatgfs	p.M382fs	SEC31B_ENST00000451524.1_Frame_Shift_Ins_p.M382fs	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	382					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CTAATCCATTTGGGGGGTTTTT	0.490													10	817	---	---	---	---					
NPM3	10360	broad.mit.edu	37	10	103541502	103541503	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:103541502_103541503insC	ENST00000370110.5	-	5	549_550	c.527_528insG	c.(526-528)gagfs	p.E176fs	NPM3_ENST00000474993.1_5'UTR	NM_006993.2	NP_008924.1	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	176							nucleic acid binding			large_intestine(3)|lung(1)|skin(1)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GCTAGGGCCTGCCCCCCTGCTT	0.564											OREG0020469	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	1617	---	---	---	---					
PPRC1	23082	broad.mit.edu	37	10	103901076	103901077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:103901076_103901077insC	ENST00000278070.2	+	5	2850_2851	c.2811_2812insC	c.(2809-2814)ctccccfs	p.LP937fs	PPRC1_ENST00000413464.2_Frame_Shift_Ins_p.LP937fs	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	937	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATCCTTGCCTGCCCCCCCCACC	0.604													21	105	---	---	---	---					
PPRC1	23082	broad.mit.edu	37	10	103908247	103908248	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:103908247_103908248insC	ENST00000278070.2	+	10	4558_4559	c.4519_4520insC	c.(4519-4521)cccfs	p.P1507fs	PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000370012.1_Frame_Shift_Ins_p.P474fs|PPRC1_ENST00000413464.2_Frame_Shift_Ins_p.P1243fs	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1507	Arg-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ACGATCCCCATCCCCCCGCCGG	0.554													9	722	---	---	---	---					
PSD	5662	broad.mit.edu	37	10	104164414	104164415	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:104164414_104164415insG	ENST00000020673.5	-	15	3151_3152	c.2625_2626insC	c.(2623-2628)cctcccfs	p.P876fs	PSD_ENST00000406432.1_Frame_Shift_Ins_p.P876fs	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	876					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GCAGCTGGGAAGGGGGGCGCAG	0.609													7	555	---	---	---	---					
ABLIM1	3983	broad.mit.edu	37	10	116207654	116207655	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:116207654_116207655insG	ENST00000369252.4	-	15	1840_1841	c.1539_1540insC	c.(1537-1542)cccattfs	p.I514fs	ABLIM1_ENST00000369253.2_Frame_Shift_Ins_p.I197fs|ABLIM1_ENST00000277895.5_Frame_Shift_Ins_p.I574fs|ABLIM1_ENST00000392952.3_Frame_Shift_Ins_p.I251fs|ABLIM1_ENST00000369266.3_Frame_Shift_Ins_p.I251fs|ABLIM1_ENST00000533213.2_Frame_Shift_Ins_p.I514fs	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	574					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		ACAGCAAATGAGGGGGGACCAG	0.490													9	422	---	---	---	---					
BNIP3	664	broad.mit.edu	37	10	133784369	133784370	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr10:133784369_133784370insG	ENST00000540159.1	-	4	503_504	c.389_splice	c.e4+1	p.G130_splice	BNIP3_ENST00000368636.4_Splice_Site_p.G130_splice			Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 3	130					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CACACTCACTTGGGGGGAATAT	0.475													8	308	---	---	---	---					
CARS	833	broad.mit.edu	37	11	3023250	3023251	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:3023250_3023251insG	ENST00000397114.3	-	22	2407_2408	c.2031_2032insC	c.(2029-2034)ccgtgafs	p.*678fs	CARS_ENST00000401769.3_Frame_Shift_Ins_p.*701fs|CARS_ENST00000278224.9_Frame_Shift_Ins_p.*688fs|CARS_ENST00000380525.4_Frame_Shift_Ins_p.*771fs|CARS_ENST00000470221.2_5'UTR|CARS_ENST00000397111.5_Frame_Shift_Ins_p.*688fs			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	688					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	AACATCTCACTGGGGGGAATCT	0.495			T	ALK	ALCL								9	1015	---	---	---	---					
TRIM21	6737	broad.mit.edu	37	11	4409704	4409705	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:4409704_4409705insT	ENST00000254436.7	-	4	672_673	c.560_561insA	c.(559-561)attfs	p.I187fs	TRIM21_ENST00000543625.1_Frame_Shift_Ins_p.I187fs	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	187					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CAACCAGGAAGTTTTTTTGCTG	0.485													10	1117	---	---	---	---					
OR52B6	340980	broad.mit.edu	37	11	5602545	5602546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:5602545_5602546insC	ENST00000345043.2	+	1	439_440	c.439_440insC	c.(439-441)cccfs	p.P147fs	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATCTGCTCCCCCCTGCGA	0.510													7	776	---	---	---	---					
OR56B1	387748	broad.mit.edu	37	11	5758618	5758619	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:5758618_5758619insC	ENST00000317121.3	+	1	938_939	c.872_873insC	c.(871-873)accfs	p.T291fs	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		CACAACATCATCCCCCCTTCCC	0.406													10	1867	---	---	---	---					
OR56B4	196335	broad.mit.edu	37	11	6129868	6129869	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:6129868_6129869insC	ENST00000316529.3	+	1	955_956	c.860_861insC	c.(859-861)accfs	p.T287fs	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACAATGTCATCCCCCCTGCAC	0.510													14	679	---	---	---	---					
C11orf42	160298	broad.mit.edu	37	11	6226858	6226859	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:6226858_6226859insC	ENST00000316375.2	+	1	63_64	c.13_14insC	c.(13-15)cccfs	p.P5fs		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	5										endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTTGGTGGGTACCCCCAACCTG	0.584													15	629	---	---	---	---					
FAM160A2	84067	broad.mit.edu	37	11	6244063	6244064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:6244063_6244064insC	ENST00000265978.4	-	5	1358_1359	c.1000_1001insG	c.(1000-1002)catfs	p.H334fs	FAM160A2_ENST00000524416.1_Frame_Shift_Ins_p.H334fs|FAM160A2_ENST00000449352.2_Frame_Shift_Ins_p.H334fs	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	334					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGACCCATGACAGGCACCAGG	0.545													17	752	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6655045	6655046	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:6655045_6655046insG	ENST00000299441.3	-	4	2603_2604	c.2192_2193insC	c.(2191-2193)cctfs	p.P731fs	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	731	Cadherin 7.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTAAAAAGTGGGGGGCTGTT	0.604													7	306	---	---	---	---					
EIF4G2	1982	broad.mit.edu	37	11	10820934	10820935	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:10820934_10820935insG	ENST00000526148.1	-	20	2871_2872	c.2361_2362insC	c.(2359-2364)ccgcgafs	p.R788fs	EIF4G2_ENST00000396525.2_Frame_Shift_Ins_p.R750fs|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000525681.1_Frame_Shift_Ins_p.R788fs|EIF4G2_ENST00000339995.5_Frame_Shift_Ins_p.R788fs	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	788	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.S788R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTTTCATCGCTGGGGGGGTTTA	0.406													7	105	---	---	---	---					
PIK3C2A	5286	broad.mit.edu	37	11	17191096	17191097	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:17191096_17191097insT	ENST00000265970.7	-	1	191_192	c.192_193insA	c.(190-195)aacacafs	p.NT64fs	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	64	Interaction with clathrin.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TAAACCTGTGCTTTTTTTCTGG	0.401													8	1197	---	---	---	---					
HPS5	11234	broad.mit.edu	37	11	18303689	18303690	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:18303689_18303690insG	ENST00000396253.3	-	21	3256_3257	c.2794_2795insC	c.(2794-2796)ggafs	p.G932fs	HPS5_ENST00000537258.1_Frame_Shift_Ins_p.G153fs|HPS5_ENST00000349215.3_Frame_Shift_Ins_p.G1046fs|HPS5_ENST00000438420.2_Frame_Shift_Ins_p.G932fs|HPS5_ENST00000352460.3_5'UTR	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	1046						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TAGTGACTCCTGGGGGGCTGGC	0.554									Hermansky-Pudlak syndrome				8	182	---	---	---	---					
NAV2	89797	broad.mit.edu	37	11	20067148	20067149	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:20067148_20067149insA	ENST00000396085.1	+	14	4195_4196	c.3834_3835insA	c.(3832-3837)tcgtccfs	p.S1279fs	NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000360655.4_Frame_Shift_Ins_p.S1215fs|NAV2_ENST00000311043.8_Frame_Shift_Ins_p.S365fs|NAV2_ENST00000396087.3_Frame_Shift_Ins_p.S1302fs|NAV2_ENST00000540292.1_Frame_Shift_Ins_p.S1233fs|NAV2_ENST00000533917.1_Frame_Shift_Ins_p.S365fs|NAV2_ENST00000349880.4_Frame_Shift_Ins_p.S1279fs|NAV2_ENST00000527559.2_Frame_Shift_Ins_p.S1231fs	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1302						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AGCCTGTGTCCAGTCCGGCTCA	0.545													11	176	---	---	---	---					
KCNA4	3739	broad.mit.edu	37	11	30032939	30032940	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:30032939_30032940insC	ENST00000328224.6	-	2	2519_2520	c.1286_1287insG	c.(1285-1287)gggfs	p.G429fs		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	429						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity	p.G429fs*53(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GACCATTGCCACCCCCCTGTTG	0.500													10	868	---	---	---	---					
PAX6	5080	broad.mit.edu	37	11	31812316	31812317	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:31812316_31812317insG	ENST00000419022.1	-	13	1634_1635	c.1166_1167insC	c.(1165-1167)ccafs	p.P389fs	PAX6_ENST00000379111.2_Frame_Shift_Ins_p.P375fs|PAX6_ENST00000379107.2_Frame_Shift_Ins_p.P389fs|PAX6_ENST00000241001.8_Frame_Shift_Ins_p.P375fs|PAX6_ENST00000379129.2_Frame_Shift_Ins_p.P389fs|PAX6_ENST00000379132.3_Frame_Shift_Ins_p.P375fs|PAX6_ENST00000379123.5_Frame_Shift_Ins_p.P375fs|PAX6_ENST00000379115.4_Frame_Shift_Ins_p.P389fs	NM_001127612.1|NM_001258462.1|NM_001258463.1	NP_001121084.1|NP_001245391.1|NP_001245392.1	P26367	PAX6_HUMAN	paired box 6	375	Pro/Ser/Thr-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)	35	Lung SC(675;0.225)					TCTGCATATGTGGGGGGGTGTA	0.589									Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation				9	101	---	---	---	---					
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:34904908_34904909insC	ENST00000395787.3	-	6	818_819	c.604_605insG	c.(604-606)aacfs	p.N202fs	APIP_ENST00000527830.1_5'UTR|APIP_ENST00000278359.5_Frame_Shift_Ins_p.N219fs	NM_015957.2	NP_057041.2	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity			kidney(2)|lung(1)|skin(1)	4	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.450													7	620	---	---	---	---					
PAMR1	25891	broad.mit.edu	37	11	35513669	35513670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:35513669_35513670insC	ENST00000378880.2	-	3	747_748	c.302_303insG	c.(301-303)gacfs	p.D101fs	PAMR1_ENST00000278360.3_Frame_Shift_Ins_p.D101fs|PAMR1_ENST00000534803.1_5'UTR|PAMR1_ENST00000378878.3_Frame_Shift_Ins_p.D101fs|PAMR1_ENST00000532848.1_Frame_Shift_Ins_p.D61fs	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	101					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CATCCAAGGTACCCCCCCATGA	0.520													52	798	---	---	---	---					
ACCSL	390110	broad.mit.edu	37	11	44080010	44080011	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:44080010_44080011insT	ENST00000378832.1	+	12	1526		c.e12+1			NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like								1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						CTTGAAAAAGGTGTGTTCTGGG	0.535													17	283	---	---	---	---					
CKAP5	9793	broad.mit.edu	37	11	46784654	46784655	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:46784654_46784655insA	ENST00000529230.1	-	30	3808_3809	c.3762_3763insT	c.(3760-3765)ttacacfs	p.LH1254fs	CKAP5_ENST00000354558.3_Frame_Shift_Ins_p.LH1254fs|CKAP5_ENST00000312055.5_Frame_Shift_Ins_p.LH1254fs|CKAP5_ENST00000415402.1_Frame_Shift_Ins_p.LH1254fs			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1254					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						GTATTGGTGTCAAAAAACCTCA	0.361													7	817	---	---	---	---					
C11orf49	79096	broad.mit.edu	37	11	47074000	47074001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:47074000_47074001insC	ENST00000395460.2	+	3	249_250	c.211_212insC	c.(211-213)cccfs	p.P71fs	C11orf49_ENST00000278460.7_Frame_Shift_Ins_p.P71fs|C11orf49_ENST00000378615.3_Frame_Shift_Ins_p.P71fs|C11orf49_ENST00000536126.1_5'UTR|C11orf49_ENST00000543718.1_Intron|C11orf49_ENST00000378618.2_Frame_Shift_Ins_p.P71fs|C11orf49_ENST00000527268.1_3'UTR	NM_001003676.1	NP_001003676.1	Q9H6J7	CK049_HUMAN	chromosome 11 open reading frame 49	71										central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(1)	11						CGTCCAAGCCACCCCCCACAAT	0.441													7	289	---	---	---	---					
KBTBD4	55709	broad.mit.edu	37	11	47594882	47594883	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:47594882_47594883insC	ENST00000533290.1	-	3	1945_1946	c.1231_1232insG	c.(1231-1233)ggafs	p.G411fs	KBTBD4_ENST00000430070.2_Frame_Shift_Ins_p.G402fs|KBTBD4_ENST00000526005.1_Frame_Shift_Ins_p.G386fs|KBTBD4_ENST00000395288.2_Frame_Shift_Ins_p.G386fs|PTPMT1_ENST00000527079.2_3'UTR|NDUFS3_ENST00000533507.1_Intron			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	386								p.E386fs*4(2)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						ATCATTCTCCTCCCCCCCTAGT	0.515													44	586	---	---	---	---					
OR4S1	256148	broad.mit.edu	37	11	48328524	48328525	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:48328524_48328525insC	ENST00000319988.1	+	1	750_751	c.750_751insC	c.(748-753)atccccfs	p.IP250fs		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						TGGTTCTCATGCCCCCCATGTT	0.480													11	1097	---	---	---	---					
OR5M1	390168	broad.mit.edu	37	11	56380547	56380550	+	Frame_Shift_Del	DEL	CAGA	CAGA	-	rs71931749		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:56380547_56380550delCAGA	ENST00000526538.1	-	1	428_431	c.429_432delTCTG	c.(427-432)tgfs	p.CL143fs		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GGATAGTGACCAGACAGACACAGA	0.436													25	290	---	---	---	---					
SLC43A3	29015	broad.mit.edu	37	11	57185234	57185235	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:57185234_57185235insG	ENST00000395123.2	-	8	961_962	c.657_658insC	c.(655-660)ccactafs	p.L220fs	SLC43A3_ENST00000529554.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000352187.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000395124.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000533524.1_Frame_Shift_Ins_p.L233fs|SLC43A3_ENST00000528098.1_5'UTR	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	220					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						TAGCTGTAGTTGGGGGGCAGTG	0.564													13	324	---	---	---	---					
ZDHHC5	25921	broad.mit.edu	37	11	57464257	57464258	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:57464257_57464258insC	ENST00000287169.3	+	10	2396_2397	c.1034_1035insC	c.(1033-1035)accfs	p.T345fs	ZDHHC5_ENST00000527985.1_Frame_Shift_Ins_p.T292fs	NM_015457.2	NP_056272.2	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC-type containing 5	345						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(6)|kidney(3)|large_intestine(3)|lung(5)|skin(1)	18						GCCAAGGACAGCCCCCCGACAC	0.515													12	284	---	---	---	---					
TMX2	51075	broad.mit.edu	37	11	57505845	57505846	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:57505845_57505846insC	ENST00000278422.4	+	4	396_397	c.384_385insC	c.(382-387)aaccccfs	p.NP128fs	TMX2_ENST00000378312.4_Frame_Shift_Ins_p.NP90fs|TMX2-CTNND1_ENST00000528395.1_Intron	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	128	Thioredoxin.				cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						TGACGTGCAAACCCCCCCTATA	0.421													11	569	---	---	---	---					
OR4D11	219986	broad.mit.edu	37	11	59271497	59271498	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:59271497_59271498insG	ENST00000313253.1	+	1	449_450	c.449_450insG	c.(448-450)aggfs	p.R150fs		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						GCCTCTTGGATGGGGGGCTTTG	0.550													8	616	---	---	---	---					
DDB1	1642	broad.mit.edu	37	11	61094367	61094368	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:61094367_61094368insG	ENST00000301764.7	-	5	947		c.e5-2		DDB1_ENST00000545930.1_Splice_Site|DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa						cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGAGGGTCCTGGGGGGGAAAG	0.515								Nucleotide excision repair (NER)					15	441	---	---	---	---					
RASGRP2	10235	broad.mit.edu	37	11	64507637	64507638	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:64507637_64507638insG	ENST00000377494.1	-	5	1294		c.e5-2		RASGRP2_ENST00000394432.3_Splice_Site|RASGRP2_ENST00000354024.3_Splice_Site|RASGRP2_ENST00000377497.3_Splice_Site			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)						platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TAGGTAGGGCTGGGGGGGCAGG	0.569													8	90	---	---	---	---					
DPP3	10072	broad.mit.edu	37	11	66272154	66272155	+	Frame_Shift_Ins	INS	-	-	C	rs142447712		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:66272154_66272155insC	ENST00000532677.1	+	17	2408_2409	c.2007_2008insC	c.(2005-2010)gcccccfs	p.AP669fs	DPP3_ENST00000453114.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000360510.2_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000541961.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000531863.1_Frame_Shift_Ins_p.AP670fs|DPP3_ENST00000530165.1_Frame_Shift_Ins_p.AP620fs	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	650					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TCACTGATGCGCCCCCCGAGTG	0.579													10	278	---	---	---	---					
CCS	9973	broad.mit.edu	37	11	66366957	66366958	+	Frame_Shift_Ins	INS	-	-	G	rs61731811	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:66366957_66366958insG	ENST00000533244.1	+	4	719_720	c.278_279insG	c.(277-279)cggfs	p.R93fs	CCS_ENST00000310190.4_Frame_Shift_Ins_p.R74fs	NM_005125.1	NP_005116.1	O14618	CCS_HUMAN	copper chaperone for superoxide dismutase	93	Superoxide dismutase-like.				intracellular copper ion transport|oxidation-reduction process|removal of superoxide radicals	cytosol|mitochondrial inner membrane|nucleus|soluble fraction	copper ion transmembrane transporter activity|protein binding|superoxide dismutase copper chaperone activity|zinc ion binding			breast(2)|cervix(1)|large_intestine(2)|lung(3)|stomach(1)	9						GTGGCCATCCTGGGGGGGCCTG	0.644													9	122	---	---	---	---					
ARRB1	408	broad.mit.edu	37	11	74988494	74988495	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:74988494_74988495insG	ENST00000420843.2	-	9	716		c.e9-2		ARRB1_ENST00000393505.4_Splice_Site|ARRB1_ENST00000360025.3_Splice_Site	NM_004041.4	NP_004032.2	P49407	ARRB1_HUMAN	arrestin, beta 1						G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(4)|large_intestine(2)|lung(4)|prostate(1)	11						GTAATAGATCTGGGGGGCATAA	0.550													8	753	---	---	---	---					
RDX	5962	broad.mit.edu	37	11	110104136	110104137	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:110104136_110104137insG	ENST00000343115.4	-	13	1731_1732	c.1412_1413insC	c.(1411-1413)cccfs	p.P471fs	RDX_ENST00000530301.1_Intron|RDX_ENST00000528498.1_Frame_Shift_Ins_p.P471fs|RDX_ENST00000405097.1_Frame_Shift_Ins_p.P471fs|RDX_ENST00000528900.1_Frame_Shift_Ins_p.P124fs|RDX_ENST00000544551.1_Frame_Shift_Ins_p.P335fs	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	471	Glu-rich.|Poly-Pro.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GTGGAGGTGGAGGGGGGGCAGA	0.431													19	556	---	---	---	---					
NCAM1	4684	broad.mit.edu	37	11	113076860	113076861	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:113076860_113076861insG	ENST00000316851.7	+	4	556_557	c.556_557insG	c.(556-558)gggfs	p.G186fs	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Frame_Shift_Ins_p.G195fs|NCAM1_ENST00000533760.1_Frame_Shift_Ins_p.G78fs	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	196	Ig-like C2-type 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AATCCTGGCACGGGGGGAGATC	0.495													13	483	---	---	---	---					
TTC12	54970	broad.mit.edu	37	11	113210159	113210160	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:113210159_113210160insG	ENST00000393020.1	+	10	1194_1195	c.789_790insG	c.(787-792)gcggggfs	p.AG263fs	TTC12_ENST00000314756.3_Frame_Shift_Ins_p.AG263fs|TTC12_ENST00000483239.2_Frame_Shift_Ins_p.AG269fs|TTC12_ENST00000529221.1_Frame_Shift_Ins_p.AG263fs			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	263							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TGTTCTATGCTGGGGGGATTGA	0.500													8	349	---	---	---	---					
CLDN25	644672	broad.mit.edu	37	11	113650550	113650551	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:113650550_113650551insG	ENST00000453129.2	+	1	82_83	c.33_34insG	c.(31-36)ctggggfs	p.LG11fs		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	11						integral to membrane|tight junction	structural molecule activity	p.L14fs*24(1)		large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						AAGTCCAGCTCGGGGGGCTACT	0.550													9	317	---	---	---	---					
BACE1	23621	broad.mit.edu	37	11	117186257	117186258	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:117186257_117186258insG	ENST00000313005.6	-	1	714_715	c.254_255insC	c.(253-255)ccafs	p.P85fs	BACE1_ENST00000513780.1_Frame_Shift_Ins_p.P85fs|BACE1_ENST00000528053.1_Frame_Shift_Ins_p.P85fs|BACE1_ENST00000514464.1_5'UTR|BACE1_ENST00000428381.2_Frame_Shift_Ins_p.P85fs|BACE1_ENST00000445823.2_Frame_Shift_Ins_p.P85fs	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236.1|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	85					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		TTACCGTCTGCGGGGGGCTGCC	0.658													7	190	---	---	---	---					
PHLDB1	23187	broad.mit.edu	37	11	118495753	118495754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:118495753_118495754insC	ENST00000361417.2	+	6	870_871	c.459_460insC	c.(457-462)ggccccfs	p.GP153fs	PHLDB1_ENST00000356063.5_Frame_Shift_Ins_p.GP153fs	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	153										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GAGCCCCTGGGCCCCCCTACAG	0.609													8	554	---	---	---	---					
DDX6	1656	broad.mit.edu	37	11	118629613	118629614	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:118629613_118629614insG	ENST00000264018.4	-	9	1170		c.e9-2		DDX6_ENST00000526070.2_Splice_Site|DDX6_ENST00000534980.1_Splice_Site	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAGC	0.426			T	IGH@	B-NHL								13	95	---	---	---	---					
ABCG4	64137	broad.mit.edu	37	11	119027095	119027096	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:119027095_119027096insG	ENST00000307417.3	+	7	1107_1108	c.743_744insG	c.(742-744)cggfs	p.R248fs	ABCG4_ENST00000449422.2_Frame_Shift_Ins_p.R248fs|ABCG4_ENST00000531739.1_Frame_Shift_Ins_p.R248fs	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	248	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCCCTGGCACAGGGGGGCCGTA	0.589													7	417	---	---	---	---					
OR10G8	219869	broad.mit.edu	37	11	123900396	123900397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:123900396_123900397insC	ENST00000431524.1	+	1	100_101	c.67_68insC	c.(67-69)cccfs	p.P23fs		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A23T(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGCGCTGGACGCCCCCCTCTTT	0.589													9	1052	---	---	---	---					
VSIG2	23584	broad.mit.edu	37	11	124620739	124620740	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:124620739_124620740insG	ENST00000403470.1	-	3	352_353	c.297_298insC	c.(295-300)cccagtfs	p.S100fs	VSIG2_ENST00000326621.5_Frame_Shift_Ins_p.S100fs			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	100	Ig-like V-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		ACCCCCACTGTGGGGGGGTTCT	0.540													11	161	---	---	---	---					
IGSF9B	22997	broad.mit.edu	37	11	133807826	133807827	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr11:133807826_133807827insG	ENST00000321016.8	-	4	669_670	c.439_440insC	c.(439-441)gtafs	p.V147fs	IGSF9B_ENST00000533871.2_Frame_Shift_Ins_p.V147fs			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	147	Ig-like 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTCGATGTACTGGGGGGGTGTT	0.574													10	78	---	---	---	---					
RAD52	5893	broad.mit.edu	37	12	1036431	1036432	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:1036431_1036432insG	ENST00000358495.3	-	6	487		c.e6-2		RAD52_ENST00000430095.2_Splice_Site|RAD52_ENST00000545564.1_Splice_Site|RAD52_ENST00000536177.1_Splice_Site|RAD52_ENST00000539046.1_Splice_Site	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)						DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TGAACCATCCTGGGGGCAGAAA	0.530								Homologous recombination					7	2513	---	---	---	---					
FOXM1	2305	broad.mit.edu	37	12	2968087	2968088	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:2968087_2968088insG	ENST00000342628.2	-	10	2235_2236	c.2122_2123insC	c.(2122-2124)tgafs	p.*708fs	FOXM1_ENST00000361953.3_Frame_Shift_Ins_p.*655fs|ITFG2_ENST00000545509.1_Intron|FOXM1_ENST00000359843.3_Frame_Shift_Ins_p.*670fs	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	670					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CGGTGATTCAAGGGGGGGAGCA	0.579													9	228	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6153463	6153464	+	Frame_Shift_Ins	INS	-	-	G	rs137990643	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:6153463_6153464insG	ENST00000261405.5	-	18	2689_2690	c.2435_2436insC	c.(2434-2436)cggfs	p.R812fs		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	812	E1.|TIL 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TCACCATGCCCGGGGGGCAGAG	0.594													12	405	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6923985	6923986	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:6923985_6923986insC	ENST00000011653.4	+	5	692_693	c.434_435insC	c.(433-435)accfs	p.T145fs	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_Frame_Shift_Ins_p.T90fs	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	145	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				ACCTTGGAGAGCCCCCCTGGTA	0.579													7	1109	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6924042	6924043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:6924042_6924043insG	ENST00000011653.4	+	5	749_750	c.491_492insG	c.(490-492)cggfs	p.R164fs	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_Frame_Shift_Ins_p.R109fs	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	164	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AAAAACATACAGGGGGGGAAGA	0.564													21	474	---	---	---	---					
ATN1	1822	broad.mit.edu	37	12	7045699	7045700	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:7045699_7045700insC	ENST00000356654.4	+	5	1506_1507	c.1269_1270insC	c.(1267-1272)caccccfs	p.HP423fs	ATN1_ENST00000396684.2_Frame_Shift_Ins_p.HP423fs	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	423					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						TCTCCAATCAGCCCCCCAAGTA	0.614													7	225	---	---	---	---					
RP11-273B20.3	0	broad.mit.edu	37	12	7338485	7338485	+	RNA	DEL	C	C	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:7338485delC	ENST00000545794.1	-	0	279				RP11-273B20.3_ENST00000543061.1_RNA																							ggatgtgcctccccctgcact	0.443													2	4	---	---	---	---					
LRP6	4040	broad.mit.edu	37	12	12274317	12274318	+	Frame_Shift_Ins	INS	-	-	G	rs145639537	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:12274317_12274318insG	ENST00000261349.4	-	23	4660_4661	c.4584_4585insC	c.(4582-4587)ccccacfs	p.H1529fs	BCL2L14_ENST00000396369.1_Intron|LRP6_ENST00000543091.1_Frame_Shift_Ins_p.H1484fs	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1529					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				CAGGGTGTGGTGGGGGGTGCAA	0.465													13	1280	---	---	---	---					
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:14019043_14019044insG	ENST00000279593.3	-	2	308_309	c.99_100insC	c.(97-102)ccgcatfs	p.H34fs		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	34					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589													12	191	---	---	---	---					
GUCY2C	2984	broad.mit.edu	37	12	14825856	14825857	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:14825856_14825857insC	ENST00000261170.3	-	9	1256_1257	c.1120_1121insG	c.(1120-1122)tgtfs	p.C374fs	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	374					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACTGTCAACATCCCCCCAGTCA	0.470													10	308	---	---	---	---					
WBP11	51729	broad.mit.edu	37	12	14940365	14940366	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:14940365_14940366insG	ENST00000261167.2	-	12	1792_1793	c.1559_1560insC	c.(1558-1560)cggfs	p.R520fs	WBP11_ENST00000537574.1_Frame_Shift_Ins_p.R486fs	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	520	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding	p.G521fs*28(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GGAACAGCCCAGGGGGGGCAGG	0.550													13	203	---	---	---	---					
KLHL42	57542	broad.mit.edu	37	12	27950768	27950769	+	Frame_Shift_Ins	INS	-	-	G	rs145908611	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:27950768_27950769insG	ENST00000381271.2	+	3	1498_1499	c.1187_1188insG	c.(1186-1188)gggfs	p.G396fs		NM_020782.1	NP_065833.1			kelch-like family member 42																		ATCTACATCGTGGGGGGGTGTC	0.594													52	550	---	---	---	---					
PCED1B	91523	broad.mit.edu	37	12	47628997	47628998	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:47628997_47628998insG	ENST00000546455.1	+	4	882_883	c.151_152insG	c.(151-153)gggfs	p.G51fs	PCED1B_ENST00000432328.1_Frame_Shift_Ins_p.G51fs					PC-esterase domain containing 1B									p.R51G(1)									GCTTAGAGCAAGGGGGGAGCTG	0.614													7	402	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49445525	49445526	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:49445525_49445526insG	ENST00000301067.7	-	10	1939_1940	c.1940_1941insC	c.(1939-1941)cccfs	p.P647fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ATACCTCAGGTGGGGGGGACAT	0.634													7	170	---	---	---	---					
LIMA1	51474	broad.mit.edu	37	12	50571521	50571522	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:50571521_50571522insG	ENST00000547825.1	-	5	1968_1969	c.699_700insC	c.(697-702)ccctgafs	p.*234fs	LIMA1_ENST00000552909.1_Frame_Shift_Ins_p.*375fs|LIMA1_ENST00000552823.1_Frame_Shift_Ins_p.*376fs|LIMA1_ENST00000394943.3_Frame_Shift_Ins_p.*537fs|LIMA1_ENST00000552783.1_Frame_Shift_Ins_p.*377fs|LIMA1_ENST00000552491.1_Frame_Shift_Ins_p.*233fs|LIMA1_ENST00000341247.4_Frame_Shift_Ins_p.*536fs	NM_001243775.1	NP_001230704.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	536					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						CCAAGTTCAGTGGGGGGTGGCC	0.540													7	302	---	---	---	---					
KRT73	319101	broad.mit.edu	37	12	53001990	53001991	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53001990_53001991insT	ENST00000305748.3	-	9	1646_1647	c.1612_1613insA	c.(1612-1614)catfs	p.H538fs	RP11-641A6.2_ENST00000551089.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	538	Tail.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TTATCTCATGGTTTTTTTGGTG	0.535													8	402	---	---	---	---					
EIF4B	1975	broad.mit.edu	37	12	53427591	53427592	+	Splice_Site	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53427591_53427592insC	ENST00000262056.9	+	9	1307_1308	c.979_splice	c.e9-1	p.GP327_splice	EIF4B_ENST00000420463.3_Splice_Site_p.GP327_splice|EIF4B_ENST00000416762.3_Splice_Site_p.GP288_splice|RP11-983P16.4_ENST00000552905.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	327	Arg-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						TTAACTTAGGTCCCCCCCAAAG	0.426													9	105	---	---	---	---					
AAAS	8086	broad.mit.edu	37	12	53715141	53715142	+	Frame_Shift_Ins	INS	-	-	G	rs138043864		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53715141_53715142insG	ENST00000209873.4	-	1	273_274	c.108_109insC	c.(106-111)ccacttfs	p.L37fs	AAAS_ENST00000549983.1_Intron|AAAS_ENST00000550286.1_Intron|AAAS_ENST00000394384.3_Frame_Shift_Ins_p.L37fs	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	37					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CCCCGGAAGTCGGGGGGCGGGC	0.653													11	384	---	---	---	---					
SP1	6667	broad.mit.edu	37	12	53776725	53776727	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53776725_53776727delACC	ENST00000426431.2	+	3	1033_1035	c.973_975delACC	c.(973-975)del	p.T326del	SP1_ENST00000327443.4_In_Frame_Del_p.T333del	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	333	Ser/Thr-rich.|Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		AACTACTACTACCACCAGCAACA	0.502													9	174	---	---	---	---					
MAP3K12	7786	broad.mit.edu	37	12	53876882	53876883	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53876882_53876883insG	ENST00000267079.2	-	12	1830_1831	c.1605_1606insC	c.(1603-1608)cccaccfs	p.T536fs	MAP3K12_ENST00000547035.1_Frame_Shift_Ins_p.T569fs|MAP3K12_ENST00000547488.1_Frame_Shift_Ins_p.T569fs	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	536					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						CGTCCTGGTGAGGGGGGGCCCT	0.639													9	153	---	---	---	---					
TARBP2	6895	broad.mit.edu	37	12	53898183	53898184	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:53898183_53898184insC	ENST00000266987.2	+	5	908_909	c.425_426insC	c.(424-426)accfs	p.T142fs	TARBP2_ENST00000394357.2_Frame_Shift_Ins_p.T121fs|TARBP2_ENST00000552857.1_Frame_Shift_Ins_p.T51fs|TARBP2_ENST00000456234.2_Frame_Shift_Ins_p.T121fs	NM_134323.1	NP_599150.1	Q15633	TRBP2_HUMAN	TAR (HIV-1) RNA binding protein 2	142					miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)	10						TCCTTCAGGAGCCCCCCCATGG	0.564													7	195	---	---	---	---					
NEUROD4	58158	broad.mit.edu	37	12	55421127	55421128	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:55421127_55421128insC	ENST00000242994.3	+	2	1282_1283	c.904_905insC	c.(904-906)cccfs	p.P302fs		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	302					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						TCAGGCTGGTACCCCCCGTTAT	0.465													21	2116	---	---	---	---					
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:56347513_56347514insC	ENST00000331886.5	+	24	2623_2624	c.2169_2170insC	c.(2167-2172)ccccccfs	p.PP723fs	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Frame_Shift_Ins_p.PP723fs|DGKA_ENST00000551156.1_Frame_Shift_Ins_p.PP723fs	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579													7	152	---	---	---	---					
IKZF4	64375	broad.mit.edu	37	12	56429092	56429093	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:56429092_56429093insG	ENST00000262032.5	+	12	2102_2103	c.1735_1736insG	c.(1735-1737)gggfs	p.G579fs	RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000431367.2_Frame_Shift_Ins_p.G477fs|IKZF4_ENST00000547791.1_Frame_Shift_Ins_p.G534fs|IKZF4_ENST00000547167.1_Frame_Shift_Ins_p.G579fs			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	579					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCACATTGTCCGGGGGGAGCAT	0.554													28	827	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56558259	56558260	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:56558259_56558260insG	ENST00000550164.1	-	28	3502_3503	c.3488_3489insC	c.(3487-3489)cccfs	p.P1163fs	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000267064.4_Frame_Shift_Ins_p.P1132fs|SMARCC2_ENST00000394023.3_Intron|SMARCC2_ENST00000347471.4_Intron			Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1132	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCAGGTTAGGTGGGGGGAGAGT	0.614													10	441	---	---	---	---					
STAT2	6773	broad.mit.edu	37	12	56742816	56742817	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:56742816_56742817insG	ENST00000314128.4	-	17	1490_1491	c.1467_1468insC	c.(1465-1470)ccaggcfs	p.G490fs	STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000418572.2_3'UTR|STAT2_ENST00000557235.1_Frame_Shift_Ins_p.G486fs			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	490					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						CAGGGGGCCTTGGGGGGGTTGG	0.594													20	389	---	---	---	---					
BAZ2A	11176	broad.mit.edu	37	12	57009177	57009178	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:57009177_57009178insC	ENST00000179765.5	-	3	549_550	c.350_351insG	c.(349-351)gcafs	p.A117fs	BAZ2A_ENST00000379441.3_Frame_Shift_Ins_p.A119fs|BAZ2A_ENST00000551812.1_Frame_Shift_Ins_p.A119fs|BAZ2A_ENST00000549884.1_Frame_Shift_Ins_p.A117fs			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	119					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GTGGGTATTGTCCCCCCGAGAA	0.584													8	218	---	---	---	---					
NACA	4666	broad.mit.edu	37	12	57114417	57114418	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:57114417_57114418insG	ENST00000454682.1	-	3	1177_1178	c.896_897insC	c.(895-897)cgafs	p.R299fs	NACA_ENST00000550952.1_Frame_Shift_Ins_p.R299fs|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGAAAATCTGGGGGGGTGTT	0.490			T	BCL6	NHL								7	39	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57572241	57572242	+	Frame_Shift_Ins	INS	-	-	G	rs139915490		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:57572241_57572242insG	ENST00000243077.3	+	27	4927_4928	c.4461_4462insG	c.(4459-4464)taggggfs	p.*G1487fs		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1487					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGACGCTGTACGGGGGGGAGGT	0.589													14	292	---	---	---	---					
DCTN2	10540	broad.mit.edu	37	12	57927805	57927806	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:57927805_57927806insG	ENST00000548249.1	-	7	866_867	c.599_600insC	c.(598-600)cgafs	p.R200fs	DCTN2_ENST00000543672.1_Frame_Shift_Ins_p.R205fs|DCTN2_ENST00000537439.1_Frame_Shift_Ins_p.R177fs|DCTN2_ENST00000434715.3_Frame_Shift_Ins_p.R205fs	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	200					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						GGCTGCTATCTGGGGGGGTCCC	0.500													13	613	---	---	---	---					
MDM2	4193	broad.mit.edu	37	12	69233089	69233090	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:69233089_69233090insC	ENST00000462284.1	+	11	1256_1257	c.954_955insC	c.(952-957)aaccccfs	p.NP318fs	MDM2_ENST00000540827.1_Frame_Shift_Ins_p.NP117fs|MDM2_ENST00000517852.1_Intron|MDM2_ENST00000428863.2_Frame_Shift_Ins_p.NP91fs|MDM2_ENST00000393410.1_Frame_Shift_Ins_p.NP64fs|MDM2_ENST00000545204.1_Intron|MDM2_ENST00000393412.3_Frame_Shift_Ins_p.NP39fs|MDM2_ENST00000393413.3_Frame_Shift_Ins_p.NP39fs|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000258149.5_Frame_Shift_Ins_p.NP257fs|MDM2_ENST00000360430.2_Frame_Shift_Ins_p.NP117fs|MDM2_ENST00000356290.4_Frame_Shift_Ins_p.NP142fs|MDM2_ENST00000350057.5_Frame_Shift_Ins_p.NP287fs|MDM2_ENST00000348801.2_Frame_Shift_Ins_p.NP86fs|MDM2_ENST00000299252.4_Frame_Shift_Ins_p.NP142fs|MDM2_ENST00000258148.7_Frame_Shift_Ins_p.NP263fs|MDM2_ENST00000478070.1_3'UTR	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	312	Necessary for interaction with USP2.|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ATGAAATGAATCCCCCCCTTCC	0.426			A		"""sarcoma, glioma, colorectal, other"""								8	386	---	---	---	---					
BEST3	144453	broad.mit.edu	37	12	70049361	70049362	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:70049361_70049362insG	ENST00000330891.5	-	10	1558_1559	c.1332_1333insC	c.(1330-1335)ccgggcfs	p.PG444fs	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Frame_Shift_Ins_p.PG338fs|BEST3_ENST00000488961.1_Frame_Shift_Ins_p.PG231fs	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	444						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGTGAGGCCCTGGGGGGGTTTC	0.594													12	295	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78400511	78400512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:78400511_78400512insC	ENST00000397909.2	+	8	1366_1367	c.1193_1194insC	c.(1192-1194)cccfs	p.P398fs	NAV3_ENST00000536525.2_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000228327.6_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000266692.7_Frame_Shift_Ins_p.P398fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACTGCTTTACGCCCCCCGCAGC	0.495										HNSCC(70;0.22)			10	374	---	---	---	---					
TMCC3	57458	broad.mit.edu	37	12	94975857	94975858	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:94975857_94975858insG	ENST00000261226.4	-	2	666_667	c.535_536insC	c.(535-537)ttgfs	p.L179fs	TMCC3_ENST00000551457.1_Frame_Shift_Ins_p.L148fs	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	179						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CTCCATGCAATGGGGGGCAGTT	0.495													12	1162	---	---	---	---					
PAH	5053	broad.mit.edu	37	12	103237523	103237524	+	Frame_Shift_Ins	INS	-	-	G	rs62508574		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:103237523_103237524insG	ENST00000553106.1	-	11	1571_1572	c.1099_1100insC	c.(1099-1101)ggafs	p.G367fs	PAH_ENST00000307000.2_Frame_Shift_Ins_p.G362fs	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	367			Missing (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CTCCAGCTCCAGGGGGAGAAGC	0.465													7	853	---	---	---	---					
STAB2	55576	broad.mit.edu	37	12	104131518	104131519	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:104131518_104131519insG	ENST00000388887.2	+	53	5861_5862	c.5657_5658insG	c.(5656-5658)cggfs	p.R1886fs		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1886					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GATCCCACCCTGGGGGGCCGCT	0.510													7	638	---	---	---	---					
ACACB	32	broad.mit.edu	37	12	109604774	109604775	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:109604774_109604775insG	ENST00000338432.7	+	3	881_882	c.762_763insG	c.(760-765)ttggggfs	p.LG254fs	ACACB_ENST00000377848.3_Frame_Shift_Ins_p.LG254fs|ACACB_ENST00000377854.5_Frame_Shift_Ins_p.LG254fs			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	254					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCACACGCTTTGGGGGGGATCG	0.614													13	326	---	---	---	---					
UBE3B	89910	broad.mit.edu	37	12	109939222	109939223	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:109939222_109939223insG	ENST00000342494.3	+	13	1760_1761	c.1165_1166insG	c.(1165-1167)gggfs	p.G389fs	UBE3B_ENST00000434735.2_Frame_Shift_Ins_p.G389fs|UBE3B_ENST00000280774.5_Frame_Shift_Ins_p.G389fs	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	389					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GCAGTTCTTGTGGGGGGTGCCT	0.554													13	824	---	---	---	---					
ACAD10	80724	broad.mit.edu	37	12	112130538	112130539	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:112130538_112130539insC	ENST00000455480.2	+	2	202_203	c.25_26insC	c.(25-27)cccfs	p.P9fs	ACAD10_ENST00000549590.1_Frame_Shift_Ins_p.P9fs|ACAD10_ENST00000392636.2_5'UTR|ACAD10_ENST00000313698.4_Frame_Shift_Ins_p.P9fs|ACAD10_ENST00000413681.3_3'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	9							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups	p.S9F(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CTGTTTCCAGTCCCCCCGTCTC	0.619													18	942	---	---	---	---					
SLC8B1	80024	broad.mit.edu	37	12	113758305	113758306	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:113758305_113758306insG	ENST00000552014.1	-	8	1042		c.e8-2		SLC24A6_ENST00000202831.3_Splice_Site|SLC24A6_ENST00000553238.1_Intron|SLC24A6_ENST00000546737.1_Intron			Q6J4K2	NCKX6_HUMAN							response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CGCCAGCGCCTGGGGGGAGGAG	0.644													12	764	---	---	---	---					
SDSL	113675	broad.mit.edu	37	12	113872000	113872001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:113872000_113872001insC	ENST00000403593.4	+	5	678_679	c.416_417insC	c.(415-417)gccfs	p.A139fs	SDSL_ENST00000345635.4_Frame_Shift_Ins_p.A139fs			Q96GA7	SDSL_HUMAN	serine dehydratase-like	139					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	TGGGAGAATGTCCCCCCGTTTG	0.614													7	924	---	---	---	---					
KSR2	283455	broad.mit.edu	37	12	117977604	117977605	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:117977604_117977605insG	ENST00000425217.1	-	10	1573_1574	c.1519_1520insC	c.(1519-1521)cccfs	p.P507fs	KSR2_ENST00000302438.5_Frame_Shift_Ins_p.P233fs|KSR2_ENST00000339824.5_Frame_Shift_Ins_p.P536fs|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTAGGAGGGAGGGGGGGTGCT	0.634													8	297	---	---	---	---					
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:120800902_120800903insC	ENST00000257552.2	-	6	433_434	c.345_346insG	c.(343-348)ggtgtcfs	p.V116fs		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564													15	297	---	---	---	---					
TCTN2	79867	broad.mit.edu	37	12	124171533	124171534	+	Frame_Shift_Ins	INS	-	-	C	rs149186771		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:124171533_124171534insC	ENST00000303372.5	+	6	843_844	c.715_716insC	c.(715-717)cccfs	p.P239fs	TCTN2_ENST00000426174.2_Frame_Shift_Ins_p.P238fs	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	239					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		GTGTGTGCAGTCCCCCCTTGCC	0.564													18	2065	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124846815	124846816	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr12:124846815_124846816insG	ENST00000356219.3	-	23	3108_3109	c.2953_2954insC	c.(2953-2955)ggafs	p.G985fs	NCOR2_ENST00000429285.2_Frame_Shift_Ins_p.G968fs|NCOR2_ENST00000405201.1_Frame_Shift_Ins_p.G986fs|NCOR2_ENST00000404621.1_Frame_Shift_Ins_p.G968fs|NCOR2_ENST00000404121.2_Frame_Shift_Ins_p.G539fs|NCOR2_ENST00000397355.1_Frame_Shift_Ins_p.G969fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	986					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGCGTCCTCCCGGGGGGGCTCA	0.653													2	4	---	---	---	---					
CENPJ	55835	broad.mit.edu	37	13	25480659	25480660	+	In_Frame_Ins	INS	-	-	AAA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:25480659_25480660insAAA	ENST00000381884.4	-	7	1701_1702	c.1516_1517insTTT	c.(1516-1518)tcc>TTTtcc	p.505_506insF	CENPJ_ENST00000545981.1_In_Frame_Ins_p.505_506insF	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	505					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AGGTTTTGGACACTCAGTTACA	0.436													7	176	---	---	---	---					
PABPC3	5042	broad.mit.edu	37	13	25671333	25671333	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:25671333delA	ENST00000281589.3	+	1	1034	c.997delA	c.(997-999)aafs	p.K333fs		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	333	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding	p.F335fs*19(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TGGTCGCAGCAAAGGGTTTGG	0.428													10	942	---	---	---	---					
FLT3	2322	broad.mit.edu	37	13	28608071	28608072	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:28608071_28608072insCC	ENST00000380982.4	-	15	1975_1976	c.1894_1895insGG	c.(1894-1896)tagfs	p.*632fs	FLT3_ENST00000241453.7_Frame_Shift_Ins_p.*632fs|FLT3_ENST00000537084.1_Frame_Shift_Ins_p.*632fs			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	632	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGTTTTGCTAATTCCATAAGCT	0.426			"""Mis, O"""		"""AML, ALL"""								115	1248	---	---	---	---					
KBTBD6	89890	broad.mit.edu	37	13	41705321	41705322	+	Frame_Shift_Ins	INS	-	-	C	rs147771080		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:41705321_41705322insC	ENST00000379485.1	-	1	1560_1561	c.1326_1327insG	c.(1324-1329)gggagafs	p.R443fs	KBTBD6_ENST00000499385.2_Frame_Shift_Ins_p.R377fs	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	443							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATAGGGTCTCGCCCCCCCAAAA	0.470													16	238	---	---	---	---					
CPB2	1361	broad.mit.edu	37	13	46658415	46658416	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:46658415_46658416insA	ENST00000181383.4	-	3	229_230	c.213_214insT	c.(211-216)tttaaafs	p.K72fs	CPB2_ENST00000439329.3_Frame_Shift_Ins_p.K72fs|CPB2-AS1_ENST00000606991.1_RNA|CPB2-AS1_ENST00000415033.2_RNA|CPB2-AS1_ENST00000606243.1_RNA|CPB2-AS1_ENST00000606351.1_RNA	NM_001872.3	NP_001863.3	Q96IY4	CBPB2_HUMAN	carboxypeptidase B2 (plasma)	72					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(3)|liver(1)|lung(9)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		GATGCATTTACAAAAAAATGGA	0.361													7	265	---	---	---	---					
LMO7	4008	broad.mit.edu	37	13	76375005	76375006	+	Frame_Shift_Ins	INS	-	-	G	rs74596180	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:76375005_76375006insG	ENST00000357063.3	+	8	2064_2065	c.804_805insG	c.(802-807)agggggfs	p.RG268fs	RP11-29G8.3_ENST00000563635.1_RNA|LMO7_ENST00000321797.8_5'UTR|LMO7_ENST00000526202.1_Frame_Shift_Ins_p.RG177fs|LMO7_ENST00000465261.2_5'UTR|LMO7_ENST00000377534.3_Frame_Shift_Ins_p.RG268fs|LMO7_ENST00000341547.4_Frame_Shift_Ins_p.RG268fs			Q8WWI1	LMO7_HUMAN	LIM domain 7	268						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TCACGTTGAGAGGGGGGCGTGA	0.450													14	841	---	---	---	---					
MYCBP2	23077	broad.mit.edu	37	13	77641916	77641917	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:77641916_77641917insG	ENST00000407578.2	-	71	12520_12521	c.12254_12255insC	c.(12253-12255)cgcfs	p.R4085fs	MYCBP2_ENST00000544440.2_Frame_Shift_Ins_p.R4047fs|MYCBP2_ENST00000357337.6_Frame_Shift_Ins_p.R4047fs	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4047					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGATATCTGCTGGGGGGAGGGA	0.436													10	519	---	---	---	---					
SLITRK5	26050	broad.mit.edu	37	13	88330396	88330397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr13:88330396_88330397insC	ENST00000325089.6	+	2	2972_2973	c.2753_2754insC	c.(2752-2754)accfs	p.T918fs	SLITRK5_ENST00000400028.3_Frame_Shift_Ins_p.T677fs	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	918						integral to membrane		p.S918I(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTGCTCTACAGCCCCCCGAGTG	0.545													7	162	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612063	20612064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:20612063_20612064insC	ENST00000333629.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCTCACAGCCCCCCTCTAT	0.460													9	618	---	---	---	---					
SUPT16H	11198	broad.mit.edu	37	14	21820849	21820850	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:21820849_21820850insG	ENST00000216297.2	-	26	3464_3465	c.3126_3127insC	c.(3124-3129)ccagaafs	p.E1043fs		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	1043					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTCTTTTTCTTGGGGGGTGCAG	0.480													8	384	---	---	---	---					
TRAV3	28690	broad.mit.edu	37	14	22192097	22192098	+	RNA	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:22192097_22192098insC	ENST00000390425.2	+	0	138_139																											GCTGGAAAGGACCCCCCCAATC	0.574													11	298	---	---	---	---					
ACIN1	22985	broad.mit.edu	37	14	23549377	23549378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:23549377_23549378insG	ENST00000262710.1	-	6	1667_1668	c.1340_1341insC	c.(1339-1341)ggtfs	p.G447fs	ACIN1_ENST00000457657.1_Frame_Shift_Ins_p.G407fs|ACIN1_ENST00000605057.1_Frame_Shift_Ins_p.G389fs|ACIN1_ENST00000555053.1_Frame_Shift_Ins_p.G447fs	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	447			A -> P (in dbSNP:rs941719).		apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GAATGAGGACAGCGGGGGCTGG	0.500													9	222	---	---	---	---					
DHRS4L1	728635	broad.mit.edu	37	14	24518025	24518025	+	RNA	DEL	G	G	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:24518025delG	ENST00000558293.1	+	0	668					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		AGGATGGTGAGGAAGGGGAGC	0.537													7	617	---	---	---	---					
NEDD8	4738	broad.mit.edu	37	14	24687374	24687375	+	Frame_Shift_Ins	INS	-	-	G	rs74744808		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:24687374_24687375insG	ENST00000250495.5	-	3	299_300	c.113_114insC	c.(112-114)ccafs	p.P38fs	NEDD8_ENST00000524927.1_Frame_Shift_Ins_p.P38fs|NEDD8-MDP1_ENST00000534348.1_Frame_Shift_Ins_p.P38fs|NEDD8-MDP1_ENST00000604306.1_5'UTR	NM_006156.2	NP_006147.1			neural precursor cell expressed, developmentally down-regulated 8											breast(1)|central_nervous_system(1)|large_intestine(1)|lung(2)	5				GBM - Glioblastoma multiforme(265;0.0186)		TCTGCTGTTGTGGGGGGATTCC	0.525													7	360	---	---	---	---					
NYNRIN	57523	broad.mit.edu	37	14	24885703	24885708	+	In_Frame_Del	DEL	GCAGGA	GCAGGA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:24885703_24885708delGCAGGA	ENST00000382554.3	+	9	5066_5071	c.4748_4753delGCAGGA	c.(4747-4755)tgc>t	p.CRS1583del		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1583					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						AAAGATTACTGCAGGAGCTGCTTGTT	0.583													13	53	---	---	---	---					
CTSG	1511	broad.mit.edu	37	14	25042847	25042848	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:25042847_25042848insG	ENST00000216336.2	-	5	799_800	c.763_764insC	c.(763-765)gtgfs	p.V255fs		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	255					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		AGTCAGTCACAGGGGGGTCTCC	0.490													10	1225	---	---	---	---					
PAX9	5083	broad.mit.edu	37	14	37145441	37145442	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:37145441_37145442insC	ENST00000361487.6	+	4	1035_1036	c.810_811insC	c.(808-813)tccatcfs	p.I271fs	PAX9_ENST00000554201.1_Frame_Shift_Ins_p.P80fs|PAX9_ENST00000402703.2_Frame_Shift_Ins_p.I271fs|PAX9_ENST00000557107.1_3'UTR			P55771	PAX9_HUMAN	paired box 9	271					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		GTTTTGTGTCAGCATCCAGCAT	0.485													17	428	---	---	---	---					
ABHD12B	145447	broad.mit.edu	37	14	51347189	51347190	+	Frame_Shift_Ins	INS	-	-	G	rs141865189		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:51347189_51347190insG	ENST00000337334.2	+	4	370_371	c.355_356insG	c.(355-357)gggfs	p.G119fs	ABHD12B_ENST00000353130.1_Frame_Shift_Ins_p.G42fs|ABHD12B_ENST00000395752.1_Frame_Shift_Ins_p.G12fs|PYGL_ENST00000532462.1_Intron|ABHD12B_ENST00000554241.1_3'UTR	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	119							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					CCCCAGCTGCCGGGGGGAAGAT	0.490													11	421	---	---	---	---					
KCNH5	27133	broad.mit.edu	37	14	63174302	63174303	+	Frame_Shift_Ins	INS	-	-	G	rs35940222		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:63174302_63174303insG	ENST00000322893.7	-	11	3158_3159	c.2890_2891insC	c.(2890-2892)gatfs	p.D964fs	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	964					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATGGTATCTGGGGGGGTACT	0.391													10	181	---	---	---	---					
GALNT16	57452	broad.mit.edu	37	14	69800299	69800300	+	Frame_Shift_Ins	INS	-	-	G	rs144140025		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:69800299_69800300insG	ENST00000337827.4	+	9	1276_1277	c.949_950insG	c.(949-951)gggfs	p.G317fs	GALNT16_ENST00000553669.1_Frame_Shift_Ins_p.G317fs|GALNT16_ENST00000448469.3_Frame_Shift_Ins_p.G317fs	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		GATGGACATCTGGGGGGGAGAG	0.470													21	451	---	---	---	---					
MED6	10001	broad.mit.edu	37	14	71051554	71051555	+	Frame_Shift_Ins	INS	-	-	G	rs145634622	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:71051554_71051555insG	ENST00000256379.5	-	8	745_746	c.716_717insC	c.(715-717)cgafs	p.R239fs	MED6_ENST00000554963.1_Frame_Shift_Ins_p.R239fs|MED6_ENST00000430055.2_Frame_Shift_Ins_p.R246fs|MED6_ENST00000440435.2_3'UTR	NM_005466.2	NP_005457.2	O75586	MED6_HUMAN	mediator complex subunit 6	239					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity	p.E240fs*1(1)		large_intestine(2)|lung(2)|skin(1)	5				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		TCCGTTTTTCAGGGGGGCCTTT	0.450													10	790	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72165808	72165809	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:72165808_72165809insG	ENST00000555818.1	+	11	3833_3834	c.3485_3486insG	c.(3484-3486)gggfs	p.G1162fs	SIPA1L1_ENST00000537413.1_Frame_Shift_Ins_p.G637fs|SIPA1L1_ENST00000381232.3_Frame_Shift_Ins_p.G1162fs|SIPA1L1_ENST00000358550.2_Frame_Shift_Ins_p.G1162fs	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1162					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACTGGTTCTGTGGGGGGCACTT	0.495													7	342	---	---	---	---					
VRTN	55237	broad.mit.edu	37	14	74824462	74824463	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:74824462_74824463insG	ENST00000256362.4	+	2	1217_1218	c.976_977insG	c.(976-978)gggfs	p.G326fs		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	326					transposition, DNA-mediated		DNA binding|transposase activity	p.V329fs*25(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CAGCTTCCACCGGGGGGGCGTC	0.644													11	110	---	---	---	---					
NPC2	10577	broad.mit.edu	37	14	74947387	74947388	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:74947387_74947388insC	ENST00000557510.1	-	4	530_531	c.458_459insG	c.(457-459)ggafs	p.G153fs	NPC2_ENST00000541064.1_Intron|NPC2_ENST00000555619.1_Intron|NPC2_ENST00000434013.2_Intron|NPC2_ENST00000238633.2_Intron			P61916	NPC2_HUMAN	Niemann-Pick disease, type C2	0					cholesterol efflux|cholesterol homeostasis|glycolipid transport|intracellular cholesterol transport|phospholipid transport|regulation of isoprenoid metabolic process|response to virus	extracellular region|lysosome	cholesterol binding|enzyme binding			breast(1)|endometrium(2)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.00149)		ATGCCCTCTCACCCCCAGATAG	0.450													7	855	---	---	---	---					
LTBP2	4053	broad.mit.edu	37	14	75016598	75016599	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:75016598_75016599insC	ENST00000261978.4	-	8	2142_2143	c.1756_1757insG	c.(1756-1758)gacfs	p.D586fs	LTBP2_ENST00000556690.1_Frame_Shift_Ins_p.D586fs|LTBP2_ENST00000557425.1_5'UTR	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	586	TB 1.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ACACAAAGTCACCCCCCAGAAG	0.629													9	278	---	---	---	---					
GALC	2581	broad.mit.edu	37	14	88406275	88406276	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:88406275_88406276insT	ENST00000261304.2	-	16	1990_1991	c.1884_1885insA	c.(1882-1887)aaggtafs	p.V629fs	GALC_ENST00000393569.2_Frame_Shift_Ins_p.V603fs|GALC_ENST00000544807.2_Frame_Shift_Ins_p.V573fs|GALC_ENST00000393568.4_Frame_Shift_Ins_p.V606fs	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	629					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGTGTATACCATTTTTTTGCTG	0.307													7	467	---	---	---	---					
ZC3H14	79882	broad.mit.edu	37	14	89069237	89069238	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:89069237_89069238insC	ENST00000251038.5	+	12	1805_1806	c.1580_1581insC	c.(1579-1581)accfs	p.T527fs	ZC3H14_ENST00000555900.1_Frame_Shift_Ins_p.T229fs|ZC3H14_ENST00000555755.1_Frame_Shift_Ins_p.T527fs|ZC3H14_ENST00000556945.1_Intron|ZC3H14_ENST00000557607.1_Intron|ZC3H14_ENST00000336693.4_Intron|ZC3H14_ENST00000393514.5_Frame_Shift_Ins_p.T502fs|ZC3H14_ENST00000406216.3_Intron|ZC3H14_ENST00000359301.3_Intron|ZC3H14_ENST00000318308.6_Intron|ZC3H14_ENST00000302216.8_Intron	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	527						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						GGTGTCCCCAGCCCCCCAGGAT	0.470													9	621	---	---	---	---					
PACS2	23241	broad.mit.edu	37	14	105818753	105818754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:105818753_105818754insC	ENST00000447393.1	+	3	421_422	c.246_247insC	c.(244-249)ctccccfs	p.LP82fs	PACS2_ENST00000325438.8_Frame_Shift_Ins_p.LP82fs|PACS2_ENST00000458164.2_Frame_Shift_Ins_p.LP82fs|PACS2_ENST00000547217.1_Intron|PACS2_ENST00000430725.2_Frame_Shift_Ins_p.LP15fs	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	82					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		AGATTGTGCTGCCCCCCAGTGG	0.550											OREG0022968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	666	---	---	---	---					
IGHD	3495	broad.mit.edu	37	14	106311791	106311792	+	RNA	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr14:106311791_106311792insG	ENST00000390556.2	-	0	218_219																											CCACTGCTGGAGGGGGGTGGAG	0.594													8	313	---	---	---	---					
IGHV3OR15-7	28318	broad.mit.edu	37	15	20193163	20193164	+	RNA	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:20193163_20193164insC	ENST00000558565.2	-	0	103_104																											GTCTCAGAGAACCCCCAGGCTG	0.564													7	359	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25310192	25310193	+	RNA	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:25310192_25310193insA	ENST00000549804.2	+	0	538				SNORD116-6_ENST00000384711.1_RNA|SNHG14_ENST00000551077.1_RNA																							ATGAGTCCTCCAAAAAAAACAT	0.475													8	408	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25449554	25449564	+	RNA	DEL	AAATCATTCTC	AAATCATTCTC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:25449554_25449564delAAATCATTCTC	ENST00000424208.1	+	0	2339				SNHG14_ENST00000424333.1_RNA|SNORD115-19_ENST00000363098.1_RNA	NR_003305.1																						GATGACTTAAAAATCATTCTCAAAAGGATTA	0.512													24	173	---	---	---	---					
HERC2	8924	broad.mit.edu	37	15	28478873	28478874	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:28478873_28478874insG	ENST00000261609.7	-	28	4395_4396	c.4287_4288insC	c.(4285-4290)ccagcafs	p.A1430fs		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1430					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P1429P(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACGGGATGCTCGGGGGGAAACA	0.450													13	424	---	---	---	---					
C15orf52	388115	broad.mit.edu	37	15	40630771	40630772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:40630771_40630772insG	ENST00000559313.1	-	5	624_625	c.609_610insC	c.(607-612)cccgcafs	p.A204fs		NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	204										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCCACCTGCGTGGGGGGGCTTC	0.584											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	179	---	---	---	---					
EHD4	30844	broad.mit.edu	37	15	42192889	42192890	+	Frame_Shift_Ins	INS	-	-	G	rs145578237		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:42192889_42192890insG	ENST00000220325.4	-	6	1662_1663	c.1579_1580insC	c.(1579-1581)cctfs	p.P527fs		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	527	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GGGCACGAGGTGGGGGGGCAGG	0.673													9	93	---	---	---	---					
SORD	6652	broad.mit.edu	37	15	45353365	45353366	+	Frame_Shift_Ins	INS	-	-	C	rs11542063	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:45353365_45353366insC	ENST00000267814.9	+	4	546_547	c.366_367insC	c.(364-369)acccccfs	p.TP122fs	SORD_ENST00000558580.1_Frame_Shift_Ins_p.TP101fs	NM_003104.5	NP_003095.2	Q00796	DHSO_HUMAN	sorbitol dehydrogenase	122					fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(4)	9		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	TCTGTGCCACGCCCCCCGATGA	0.530													10	384	---	---	---	---					
PRTG	283659	broad.mit.edu	37	15	55912218	55912219	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:55912218_55912219insG	ENST00000389286.4	-	20	3491_3492	c.3444_3445insC	c.(3442-3447)ccacctfs	p.P1149fs		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1149					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AATCAGAGGTTGGGGGGTGTGG	0.490													8	272	---	---	---	---					
RFX7	64864	broad.mit.edu	37	15	56386880	56386881	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:56386880_56386881insG	ENST00000423270.1	-	9	3044_3045	c.3045_3046insC	c.(3043-3048)ccgcccfs	p.P1016fs	RFX7_ENST00000317318.6_Frame_Shift_Ins_p.P1016fs|RFX7_ENST00000559447.2_Frame_Shift_Ins_p.P919fs|RFX7_ENST00000422057.1_Frame_Shift_Ins_p.P919fs	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	919					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TCAACAGGGCTGGGGGGGACAC	0.500													13	216	---	---	---	---					
ZNF609	23060	broad.mit.edu	37	15	64973566	64973567	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:64973566_64973567insC	ENST00000326648.3	+	8	4349_4350	c.4221_4222insC	c.(4219-4224)ccccccfs	p.PP1407fs		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1407						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CACTCTACCCACCCCCCAGGAG	0.470											OREG0023182	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	1774	---	---	---	---					
IGDCC4	57722	broad.mit.edu	37	15	65684710	65684711	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:65684710_65684711insG	ENST00000352385.2	-	11	2095		c.e11-2			NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4							integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CAAAAGGGACTGGGGGGCAGAG	0.564													7	173	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65917264	65917265	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:65917264_65917265insC	ENST00000261892.6	+	2	1133_1134	c.846_847insC	c.(844-849)ttccccfs	p.FP282fs	SLC24A1_ENST00000339868.6_Frame_Shift_Ins_p.FP282fs|SLC24A1_ENST00000546330.1_Frame_Shift_Ins_p.FP282fs|SLC24A1_ENST00000544319.2_Frame_Shift_Ins_p.FP282fs|SLC24A1_ENST00000537259.1_Frame_Shift_Ins_p.FP282fs|SLC24A1_ENST00000399033.4_Frame_Shift_Ins_p.FP282fs	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	282					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						ACAACCTGTTTCCCCCCAGAAG	0.505													9	216	---	---	---	---					
ANKRD34C-AS1	729911	broad.mit.edu	37	15	79529452	79529453	+	RNA	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:79529452_79529453insG	ENST00000560533.1	-	0	349																											ATAATGAGGATGGGGGGATGAC	0.490													7	527	---	---	---	---					
AP3B2	8120	broad.mit.edu	37	15	83328737	83328738	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:83328737_83328738insG	ENST00000261722.3	-	25	3167		c.e25-2		AP3B2_ENST00000535359.1_Splice_Site|AP3B2_ENST00000535348.1_Splice_Site|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			TCAGCTTTCCTGGGGGTAGAGG	0.554													7	1454	---	---	---	---					
ALPK3	57538	broad.mit.edu	37	15	85400266	85400267	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:85400266_85400267insA	ENST00000258888.5	+	6	3070_3071	c.2903_2904insA	c.(2902-2904)caafs	p.Q968fs		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	968					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCTTGTTTCCCAAAAAAACCTG	0.540													7	147	---	---	---	---					
FURIN	5045	broad.mit.edu	37	15	91424578	91424579	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:91424578_91424579insC	ENST00000268171.3	+	16	2134_2135	c.1855_1856insC	c.(1855-1857)cccfs	p.P619fs		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	619	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.Q621fs*8(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCCAGGGTTCGCCCCCCAAGTC	0.634													8	340	---	---	---	---					
FURIN	5045	broad.mit.edu	37	15	91424956	91424957	+	Frame_Shift_Ins	INS	-	-	G	rs35641241	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:91424956_91424957insG	ENST00000268171.3	+	16	2512_2513	c.2233_2234insG	c.(2233-2235)gggfs	p.G745fs		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	745					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.R745L(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CTTTAGTTTTCGGGGGGTGAAG	0.619													13	673	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540529	93540530	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:93540529_93540530insG	ENST00000394196.4	+	30	4849_4850	c.3781_3782insG	c.(3781-3783)gggfs	p.G1261fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.G1261fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1261					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TGATGTAGAGTGGGGGGTGGAA	0.411													10	373	---	---	---	---					
LINS	55180	broad.mit.edu	37	15	101109855	101109856	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:101109855_101109856insG	ENST00000314742.8	-	7	2083_2084	c.1861_1862insC	c.(1861-1863)ggcfs	p.G621fs		NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	621								p.R621fs*13(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						TTGAGAGGCCCGGGGGGAAGAC	0.525													7	755	---	---	---	---					
ALDH1A3	220	broad.mit.edu	37	15	101438349	101438350	+	Frame_Shift_Ins	INS	-	-	G	rs142377552	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:101438349_101438350insG	ENST00000329841.5	+	8	1374_1375	c.842_843insG	c.(841-843)cggfs	p.R281fs	ALDH1A3_ENST00000346623.6_Frame_Shift_Ins_p.R174fs|RP11-66B24.4_ENST00000560351.1_RNA	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	281					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACGCTGGAGCTGGGGGGGAAGA	0.569													10	142	---	---	---	---					
CHSY1	22856	broad.mit.edu	37	15	101775436	101775437	+	Frame_Shift_Ins	INS	-	-	C	rs74545602	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:101775436_101775437insC	ENST00000254190.3	-	2	1141_1142	c.666_667insG	c.(664-669)ggctggfs	p.W223fs		NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	223					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCACGCCAGGCCCCCCCATGC	0.614													27	387	---	---	---	---					
OR4F6	390648	broad.mit.edu	37	15	102346204	102346205	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr15:102346204_102346205insG	ENST00000328882.4	+	1	303_304	c.282_283insG	c.(280-285)ttggggfs	p.LG94fs		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CCATCTCTTTTGGGGGCTGTGT	0.455													8	1123	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	81765	81766	+	RNA	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:81765_81766insC	ENST00000568710.1	-	0	434																											GGCAACCCCTGCCCCCCATGTC	0.564													9	497	---	---	---	---					
SNX29	92017	broad.mit.edu	37	16	12162916	12162917	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:12162916_12162917insC	ENST00000566228.1	+	10	1315_1316	c.1246_1247insC	c.(1246-1248)cccfs	p.P416fs	SNX29_ENST00000306030.3_Frame_Shift_Ins_p.P31fs|SNX29_ENST00000323433.4_Frame_Shift_Ins_p.P31fs	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	31					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						CTGCACAGATGCCCCCCTCGGA	0.495													9	785	---	---	---	---					
NOMO1	23420	broad.mit.edu	37	16	14980694	14980695	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:14980694_14980695insC	ENST00000287667.7	+	28	3470_3471	c.3299_3300insC	c.(3298-3300)tccfs	p.S1100fs		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1100						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						TTCTTCCATTTCCCCCCACTGC	0.475													11	534	---	---	---	---					
ACSM2B	348158	broad.mit.edu	37	16	20556547	20556548	+	Frame_Shift_Ins	INS	-	-	G	rs146499503		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:20556547_20556548insG	ENST00000329697.6	-	10	1380_1381	c.1212_1213insC	c.(1210-1215)ccgcacfs	p.H405fs	ACSM2B_ENST00000565322.1_Frame_Shift_Ins_p.H326fs|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Frame_Shift_Ins_p.H405fs|ACSM2B_ENST00000567001.1_Frame_Shift_Ins_p.H405fs	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	405					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCTTCTGTGCCGGGGGGCAGGA	0.515													7	329	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	20976647	20976648	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:20976647_20976648insG	ENST00000261383.3	-	53	8557_8558	c.8558_8559insC	c.(8557-8559)cctfs	p.P2853fs	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2853	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCATGGTCAGTGGGGGGATGTT	0.460													7	554	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	21063027	21063028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:21063027_21063028insG	ENST00000261383.3	-	29	4200_4201	c.4201_4202insC	c.(4201-4203)gctfs	p.A1401fs	DNAH3_ENST00000415178.1_Frame_Shift_Ins_p.A1401fs	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1401	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GATCACCAGCCGGGGGGAGTTT	0.569													19	578	---	---	---	---					
SEZ6L2	26470	broad.mit.edu	37	16	29891248	29891249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:29891248_29891249insG	ENST00000308713.5	-	9	2036_2037	c.1509_1510insC	c.(1507-1512)ccatgcfs	p.C504fs	SEZ6L2_ENST00000350527.3_Frame_Shift_Ins_p.C434fs|SEZ6L2_ENST00000537485.1_Frame_Shift_Ins_p.C460fs|SEZ6L2_ENST00000346932.5_Frame_Shift_Ins_p.C390fs	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	504	Sushi 2.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCGATGGCATTGGGGGGCCCAG	0.604													9	774	---	---	---	---					
ITGAL	3683	broad.mit.edu	37	16	30531243	30531244	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:30531243_30531244insG	ENST00000356798.6	+	30	3474_3475	c.3294_3295insG	c.(3292-3297)atggggfs	p.MG1098fs	ITGAL_ENST00000433423.2_Frame_Shift_Ins_p.MG332fs|ITGAL_ENST00000358164.5_Frame_Shift_Ins_p.MG1014fs	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1098					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TGAGCGGCATCGGGGGGCTGCT	0.599													10	675	---	---	---	---					
SRCAP	10847	broad.mit.edu	37	16	30733909	30733910	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:30733909_30733910insG	ENST00000262518.4	+	23	4117_4118	c.3732_3733insG	c.(3730-3735)gcggggfs	p.AG1244fs	SRCAP_ENST00000395059.2_Intron|SRCAP_ENST00000344771.4_Intron	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1244	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCGTGTCAGCAGGGGGGCAGCA	0.614													15	1397	---	---	---	---					
SETD1A	9739	broad.mit.edu	37	16	30977316	30977317	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:30977316_30977317insC	ENST00000262519.8	+	8	2800_2801	c.2114_2115insC	c.(2113-2115)gccfs	p.A705fs		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCCTCAGCTGGCCCCCCCGGTG	0.644													14	140	---	---	---	---					
ITGAD	3681	broad.mit.edu	37	16	31422475	31422476	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:31422475_31422476insC	ENST00000389202.2	+	13	1484_1485	c.1435_1436insC	c.(1435-1437)cccfs	p.P479fs		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	479					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCTCATTGGGGCCCCCCATTAC	0.649													7	715	---	---	---	---					
CNGB1	1258	broad.mit.edu	37	16	57938727	57938728	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:57938727_57938728insC	ENST00000564448.1	-	26	2586_2587	c.2526_2527insG	c.(2524-2529)ggtgccfs	p.A843fs	CNGB1_ENST00000251102.8_Frame_Shift_Ins_p.A849fs			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	849					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GGGTCAGGCAGCCCCCCGATGG	0.510													9	192	---	---	---	---					
C16orf70	80262	broad.mit.edu	37	16	67180988	67180989	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:67180988_67180989insC	ENST00000219139.3	+	16	1411_1412	c.1223_1224insC	c.(1222-1224)gccfs	p.A408fs	C16orf70_ENST00000569600.1_Frame_Shift_Ins_p.A408fs	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	408								p.R411fs*4(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		ACCCTGTATGGCCCCCCCAGGC	0.594													18	349	---	---	---	---					
DPEP2	64174	broad.mit.edu	37	16	68021467	68021468	+	Frame_Shift_Ins	INS	-	-	G	rs1133090	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:68021467_68021468insG	ENST00000412757.2	-	12	2067_2068	c.1402_1403insC	c.(1402-1404)catfs	p.H468fs	DPEP2_ENST00000572888.1_Frame_Shift_Ins_p.H468fs|DPEP2_ENST00000393847.1_Frame_Shift_Ins_p.H468fs			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	468			H -> D (in dbSNP:rs1133090).		hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGGGGCCATGTGGGGGGAGGAC	0.545													17	1237	---	---	---	---					
NFATC3	4775	broad.mit.edu	37	16	68225520	68225521	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:68225520_68225521insG	ENST00000349223.5	+	9	3172_3173	c.2948_2949insG	c.(2947-2949)cggfs	p.R983fs	NFATC3_ENST00000346183.3_Frame_Shift_Ins_p.R983fs|NFATC3_ENST00000575270.1_Frame_Shift_Ins_p.R983fs|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000329524.4_Frame_Shift_Ins_p.R983fs	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	983					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AGTACGGGCCAGGGGGGTCTTT	0.505													8	1235	---	---	---	---					
GLG1	2734	broad.mit.edu	37	16	74525008	74525009	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:74525008_74525009insC	ENST00000422840.2	-	8	1338_1339	c.1339_1340insG	c.(1339-1341)gatfs	p.D447fs	GLG1_ENST00000205061.5_Frame_Shift_Ins_p.D447fs|GLG1_ENST00000447066.2_Frame_Shift_Ins_p.D436fs	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	447						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						GTGTTCAATCTCCCCCCGACAG	0.515													8	280	---	---	---	---					
CFDP1	10428	broad.mit.edu	37	16	75446448	75446449	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr16:75446448_75446449insG	ENST00000283882.3	-	3	518_519	c.386_387insC	c.(385-387)cagfs	p.Q129fs	CFDP1_ENST00000564286.1_5'UTR	NM_006324.2	NP_006315.1	Q9UEE9	CFDP1_HUMAN	craniofacial development protein 1	129	Glu-rich.				multicellular organismal development					endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5						CTTGTGTACTTGGGGGCACTTT	0.455													10	1500	---	---	---	---					
GLOD4	51031	broad.mit.edu	37	17	673668	673669	+	Frame_Shift_Ins	INS	-	-	G	rs148496651		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:673668_673669insG	ENST00000301329.6	-	6	707_708	c.622_623insC	c.(622-624)gaafs	p.E208fs	GLOD4_ENST00000536578.1_Frame_Shift_Ins_p.E199fs|GLOD4_ENST00000301328.5_Frame_Shift_Ins_p.E223fs	NM_016080.3	NP_057164.3	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	223						mitochondrion				endometrium(1)|large_intestine(1)|prostate(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TACCTCTTTCTGGGGGCAAGAG	0.480													9	1563	---	---	---	---					
PRPF8	10594	broad.mit.edu	37	17	1562780	1562781	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:1562780_1562781insC	ENST00000572621.1	-	31	5273_5274	c.5008_5009insG	c.(5008-5010)ctafs	p.L1670fs	PRPF8_ENST00000304992.6_Frame_Shift_Ins_p.L1670fs			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1670	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGAATCATAGTCCCCCCAGCGC	0.535													11	1615	---	---	---	---					
RPA1	6117	broad.mit.edu	37	17	1782982	1782983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:1782982_1782983insG	ENST00000254719.5	+	11	1191_1192	c.1081_1082insG	c.(1081-1083)gggfs	p.G361fs		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	361					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TGCTACACTGTGGGGGGAAGAT	0.530								Nucleotide excision repair (NER)					8	749	---	---	---	---					
PAFAH1B1	5048	broad.mit.edu	37	17	2583499	2583500	+	Frame_Shift_Ins	INS	-	-	G	rs113994201		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:2583499_2583500insG	ENST00000397195.5	+	10	1495_1496	c.1044_1045insG	c.(1042-1047)tcggggfs	p.SG348fs	PAFAH1B1_ENST00000451360.2_Frame_Shift_Ins_p.SG143fs|PAFAH1B1_ENST00000397193.3_3'UTR	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	348	Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						TGTTCCATTCTGGGGGGAAGTT	0.401													9	666	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3716453	3716454	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:3716453_3716454insC	ENST00000158149.3	-	14	1802_1803	c.907_908insG	c.(907-909)tctfs	p.S303fs	C17orf85_ENST00000389005.4_Frame_Shift_Ins_p.S583fs			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	583							nucleotide binding	p.A303fs*2(1)		endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		CTTAATCAGAGCCCCCCATGCC	0.505													7	495	---	---	---	---					
ZMYND15	84225	broad.mit.edu	37	17	4647723	4647724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:4647723_4647724insC	ENST00000433935.1	+	10	1701_1702	c.1644_1645insC	c.(1642-1647)ctccccfs	p.LP548fs	ZMYND15_ENST00000573751.2_Frame_Shift_Ins_p.LP548fs|ZMYND15_ENST00000269289.6_Frame_Shift_Ins_p.LP509fs|ZMYND15_ENST00000592813.1_Frame_Shift_Ins_p.LP509fs	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	509							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						GTGATGGCCTGCCCCCCGAAAG	0.594													10	232	---	---	---	---					
CAMTA2	23125	broad.mit.edu	37	17	4884523	4884524	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:4884523_4884524insC	ENST00000361571.5	-	7	1104_1105	c.693_694insG	c.(691-696)ggttggfs	p.W232fs	CAMTA2_ENST00000414043.3_Frame_Shift_Ins_p.W256fs|CAMTA2_ENST00000381311.5_Frame_Shift_Ins_p.W235fs|CAMTA2_ENST00000348066.3_Frame_Shift_Ins_p.W233fs|CAMTA2_ENST00000358183.4_Frame_Shift_Ins_p.W233fs|CAMTA2_ENST00000572543.1_Frame_Shift_Ins_p.W238fs	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	233					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						AACTTACCAAGCCCCCCACTGC	0.550											OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	598	---	---	---	---					
WSCD1	23302	broad.mit.edu	37	17	6012978	6012979	+	Frame_Shift_Ins	INS	-	-	C	rs41314099	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:6012978_6012979insC	ENST00000574946.1	+	6	1291_1292	c.901_902insC	c.(901-903)cccfs	p.P301fs	WSCD1_ENST00000317744.5_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000574232.1_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000573634.1_Frame_Shift_Ins_p.P185fs|WSCD1_ENST00000539421.1_Frame_Shift_Ins_p.P301fs			Q658N2	WSCD1_HUMAN	WSC domain containing 1	301	WSC 2.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						TGCTTACCCTACCCCCCGGTTC	0.564													10	1855	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6903739	6903740	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:6903739_6903740insC	ENST00000251535.6	+	7	945_946	c.892_893insC	c.(892-894)cccfs	p.P298fs	AC027763.2_ENST00000574377.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000399541.2_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	298	Lipoxygenase.		A -> T.		anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						ATACCTGGCTGCCCCCCTCGTT	0.554													14	1201	---	---	---	---					
PLSCR3	57048	broad.mit.edu	37	17	7294058	7294059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7294058_7294059insC	ENST00000535512.1	-	10	1742_1743	c.725_726insG	c.(724-726)gctfs	p.A242fs	PLSCR3_ENST00000574401.1_Frame_Shift_Ins_p.A242fs|PLSCR3_ENST00000576201.1_Frame_Shift_Ins_p.A242fs|PLSCR3_ENST00000576362.1_Frame_Shift_Ins_p.A218fs|C17orf61-PLSCR3_ENST00000573331.1_3'UTR|PLSCR3_ENST00000324822.11_Frame_Shift_Ins_p.A242fs			Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	242					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding			endometrium(1)|kidney(2)|urinary_tract(1)	4		Prostate(122;0.173)				CTCGGACCAGGCCCCCCCACTG	0.614													11	256	---	---	---	---					
FGF11	2256	broad.mit.edu	37	17	7343098	7343099	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7343098_7343099insG	ENST00000293829.4	+	1	753_754	c.159_160insG	c.(157-162)tgggggfs	p.WG53fs	FGF11_ENST00000575235.1_Intron|RP11-104H15.8_ENST00000576615.1_RNA|FGF11_ENST00000575331.1_5'UTR|RP11-104H15.7_ENST00000575310.1_RNA	NM_004112.2	NP_004103.1	Q92914	FGF11_HUMAN	fibroblast growth factor 11	53					cell-cell signaling|nervous system development|signal transduction		growth factor activity			central_nervous_system(1)|large_intestine(3)|ovary(1)|prostate(1)	6		Prostate(122;0.157)				TGCGACTGTgcggggggcggcc	0.738													2	4	---	---	---	---					
SLC35G6	643664	broad.mit.edu	37	17	7386029	7386030	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7386029_7386030insC	ENST00000412468.2	+	2	841_842	c.726_727insC	c.(724-729)caccccfs	p.HP242fs	ZBTB4_ENST00000311403.4_Intron	NM_001102614.1	NP_001096084.1	P0C7Q6	AMCL3_HUMAN	solute carrier family 35, member G6	242						integral to membrane		p.P243S(1)									TTGTGCTGCAGCCCCCCGTGTT	0.599													7	290	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7573943	7573944	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7573943_7573944insC	ENST00000269305.4	-	10	1272_1273	c.1083_1084insG	c.(1081-1086)gggcagfs	p.Q362fs	TP53_ENST00000455263.2_3'UTR|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000445888.2_Frame_Shift_Ins_p.Q362fs	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	362	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with USP7.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.I332fs*5(1)|p.G361fs*8(1)|p.?(1)|p.S362fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGCCCTGCTCCCCCCTGGCT	0.594		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	215	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579470	7579471	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7579470_7579471insG	ENST00000420246.2	-	4	348_349	c.216_217insC	c.(214-219)cctggcfs	p.G73fs	TP53_ENST00000455263.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.G73fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	73	Interaction with HRMT1L2.|Interaction with WWOX.		V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V73fs*76(11)|p.0?(8)|p.V73L(3)|p.G59fs*23(3)|p.R72fs*51(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	742	---	---	---	---					
WRAP53	55135	broad.mit.edu	37	17	7606714	7606715	+	Frame_Shift_Ins	INS	-	-	G	rs146634933		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7606714_7606715insG	ENST00000316024.5	+	10	3905_3906	c.1557_1558insG	c.(1555-1560)tgggggfs	p.WG519fs	WRAP53_ENST00000431639.2_Frame_Shift_Ins_p.WG519fs|WRAP53_ENST00000396463.2_Frame_Shift_Ins_p.WG519fs|WRAP53_ENST00000534050.1_Frame_Shift_Ins_p.WG486fs|WRAP53_ENST00000457584.2_Frame_Shift_Ins_p.WG519fs			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	519					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						TCTGGTGGTGTGGGGGGGCGCC	0.599													11	135	---	---	---	---					
EFNB3	1949	broad.mit.edu	37	17	7612855	7612856	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7612855_7612856insC	ENST00000226091.2	+	5	1381_1382	c.984_985insC	c.(982-987)ggccccfs	p.GP328fs		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	328					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGCAGGATGGGCCCCCCCAGAG	0.574													13	335	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7798764	7798765	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7798764_7798765insC	ENST00000380358.4	+	10	1789_1790	c.1788_1789insC	c.(1786-1791)ccccccfs	p.PP596fs	CHD3_ENST00000330494.7_Frame_Shift_Ins_p.PP537fs|CHD3_ENST00000358181.4_Frame_Shift_Ins_p.PP537fs	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	537					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CAGATGTCCCACCCCCCCGTCC	0.574													30	490	---	---	---	---					
CNTROB	116840	broad.mit.edu	37	17	7852808	7852809	+	Frame_Shift_Ins	INS	-	-	G	rs35508310		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:7852808_7852809insG	ENST00000380262.3	+	19	3683_3684	c.2758_2759insG	c.(2758-2760)gggfs	p.G920fs	CNTROB_ENST00000563694.1_Frame_Shift_Ins_p.G898fs|CNTROB_ENST00000380255.3_3'UTR|CNTROB_ENST00000565740.1_Frame_Shift_Ins_p.G899fs	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	898					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				CATGAGGAGCCGGGGGGGAGTC	0.550													7	168	---	---	---	---					
ARHGEF15	22899	broad.mit.edu	37	17	8218831	8218832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:8218831_8218832insC	ENST00000361926.3	+	7	1470_1471	c.1360_1361insC	c.(1360-1362)cccfs	p.P454fs	ARHGEF15_ENST00000421050.1_Frame_Shift_Ins_p.P454fs	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	454	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						GGACACGCTCACCCCCCGTGAT	0.629													9	888	---	---	---	---					
ARHGEF15	22899	broad.mit.edu	37	17	8222137	8222138	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:8222137_8222138insG	ENST00000361926.3	+	12	2052_2053	c.1942_1943insG	c.(1942-1944)gggfs	p.G648fs	ARHGEF15_ENST00000582060.1_3'UTR|ARHGEF15_ENST00000421050.1_Frame_Shift_Ins_p.G648fs	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	648					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AGGGTGCCGGAGGGGGGGCGTG	0.634													27	586	---	---	---	---					
ARHGEF15	22899	broad.mit.edu	37	17	8224297	8224298	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:8224297_8224298insC	ENST00000361926.3	+	16	2622_2623	c.2512_2513insC	c.(2512-2514)cccfs	p.P838fs	ARHGEF15_ENST00000421050.1_Frame_Shift_Ins_p.P838fs	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	838					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CACCCCCAATGCCCCCCCACCC	0.574													16	212	---	---	---	---					
MYH1	4619	broad.mit.edu	37	17	10419785	10419786	+	Frame_Shift_Ins	INS	-	-	C	rs147810417		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:10419785_10419786insC	ENST00000226207.5	-	3	268_269	c.174_175insG	c.(172-177)ggaggtfs	p.G59fs	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	59	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GCTGTCACCTTCCCCCCTTCCC	0.475													9	1134	---	---	---	---					
TMEM220-AS1	101101775	broad.mit.edu	37	17	10642553	10642560	+	RNA	DEL	CCTTCCTT	CCTTCCTT	-	rs72385561		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:10642553_10642560delCCTTCCTT	ENST00000583343.1	+	0	144				CTC-297N7.5_ENST00000583012.1_RNA|TMEM220-AS1_ENST00000580899.1_RNA|CTC-297N7.5_ENST00000581366.1_RNA|CTC-297N7.5_ENST00000584714.1_RNA|CTC-297N7.5_ENST00000579114.1_RNA																							cttcccttccccttccttccttccttcc	0.591													2	4	---	---	---	---					
DNAH9	1770	broad.mit.edu	37	17	11687648	11687649	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:11687648_11687649insG	ENST00000262442.3	+	41	7921_7922	c.7853_7854insG	c.(7852-7854)cggfs	p.R2618fs	DNAH9_ENST00000454412.2_Frame_Shift_Ins_p.R2618fs	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2618	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.P2618P(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTCTCCTTCCCGGGGGCAGATG	0.530													8	720	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12655969	12655970	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:12655969_12655970insC	ENST00000425538.1	+	10	1564_1565	c.1364_1365insC	c.(1363-1365)accfs	p.T455fs	MYOCD_ENST00000395988.1_Frame_Shift_Ins_p.T359fs|MYOCD_ENST00000343344.4_Frame_Shift_Ins_p.T455fs	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	455	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACCAGCTCCAGCCCCCCGATCT	0.614													8	444	---	---	---	---					
TRIM16L	147166	broad.mit.edu	37	17	18638351	18638351	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:18638351delT	ENST00000449552.2	+	7	2109	c.625delT	c.(625-627)acfs	p.Y209fs	TRIM16L_ENST00000572555.1_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000395672.2_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000571708.1_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000414850.2_Frame_Shift_Del_p.C121fs|TRIM16L_ENST00000395671.4_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000395902.3_Frame_Shift_Del_p.Y263fs			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like	209	B30.2/SPRY.					cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						GCAGAGTCTGTACCTGCACAG	0.612													8	87	---	---	---	---					
UBBP4	23666	broad.mit.edu	37	17	21731033	21731034	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:21731033_21731034insC	ENST00000584755.1	+	2	732_733	c.335_336insC	c.(334-336)accfs	p.T112fs	UBBP4_ENST00000578713.1_Frame_Shift_Ins_p.T112fs|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						AAAGAAGGCATCCCCCCCGACC	0.540													7	96	---	---	---	---					
PHF12	57649	broad.mit.edu	37	17	27233908	27233909	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:27233908_27233909insG	ENST00000332830.4	-	14	3455_3456	c.2645_2646insC	c.(2644-2646)cagfs	p.Q882fs	PHF12_ENST00000577226.1_3'UTR	NM_001033561.1	NP_001028733.1	Q96QT6	PHF12_HUMAN	PHD finger protein 12	882					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CAATACTGCTTGGGGGGGTTGG	0.510													8	231	---	---	---	---					
SSH2	85464	broad.mit.edu	37	17	27963294	27963295	+	Frame_Shift_Ins	INS	-	-	G	rs35554312		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:27963294_27963295insG	ENST00000269033.3	-	14	2023_2024	c.1872_1873insC	c.(1870-1875)cctgtcfs	p.V625fs	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Frame_Shift_Ins_p.V652fs	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	625					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCAGGGGACATGGGGGGGTCTT	0.470													14	217	---	---	---	---					
ASIC2	40	broad.mit.edu	37	17	31439004	31439005	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:31439004_31439005insC	ENST00000225823.2	-	2	1661_1662	c.789_790insG	c.(787-792)ggcaggfs	p.R264fs	ASIC2_ENST00000448983.1_5'UTR|ASIC2_ENST00000359872.6_Frame_Shift_Ins_p.R213fs|RP11-40A13.1_ENST00000584688.1_RNA	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	213					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CCGTTGCCTGTCCCCCCCTTGA	0.550													9	221	---	---	---	---					
ACACA	31	broad.mit.edu	37	17	35487100	35487101	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:35487100_35487101insC	ENST00000353139.5	-	46	6204_6205	c.5723_5724insG	c.(5722-5724)gatfs	p.D1908fs	ACACA_ENST00000361253.5_5'UTR|ACACA_ENST00000394406.2_Frame_Shift_Ins_p.D1871fs|ACACA_ENST00000360679.3_Frame_Shift_Ins_p.D1813fs|ACACA_ENST00000335166.5_Frame_Shift_Ins_p.D1793fs	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1871	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAATCTGGATGCCCCCCAGCTG	0.495													12	580	---	---	---	---					
HNF1B	6928	broad.mit.edu	37	17	36059173	36059174	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:36059173_36059174insG	ENST00000225893.4	-	8	1922_1923	c.1561_1562insC	c.(1561-1563)gtafs	p.V521fs	HNF1B_ENST00000561193.1_Frame_Shift_Ins_p.V495fs|HNF1B_ENST00000560016.1_Intron|HNF1B_ENST00000427275.2_Intron	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	521					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GTGGGAATACTGGGGGGGTTCC	0.515													9	138	---	---	---	---					
MLLT6	4302	broad.mit.edu	37	17	36868997	36868998	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:36868997_36868998insC	ENST00000325718.7	+	8	865_866	c.774_775insC	c.(772-777)tcccccfs	p.SP258fs	MLLT6_ENST00000378137.5_Frame_Shift_Ins_p.SP258fs	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	258					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					GGCCTGAGTCGCCCCCCAGCAT	0.614			T	MLL	AL								7	246	---	---	---	---					
PCGF2	7703	broad.mit.edu	37	17	36896586	36896587	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:36896586_36896587insC	ENST00000580830.1	-	4	770_771	c.69_70insG	c.(67-72)ggacttfs	p.L24fs	PCGF2_ENST00000360797.2_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000579882.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000585100.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000578109.1_Intron|PCGF2_ENST00000581345.1_Frame_Shift_Ins_p.L24fs			P35227	PCGF2_HUMAN	polycomb group ring finger 2	24					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					TCGATGAAGTACCCCCCGCAGA	0.629													14	498	---	---	---	---					
RPL23	9349	broad.mit.edu	37	17	37008858	37008859	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:37008858_37008859insT	ENST00000479035.2	-	3	356_357	c.226_splice	c.e3+1	p.S75_splice	RPL23_ENST00000394333.1_Splice_Site_p.S75_splice|RPL23_ENST00000394332.1_Splice_Site_p.S75_splice|RPL23_ENST00000245857.5_Splice_Site_p.S16_splice|RPL23_ENST00000577407.1_Splice_Site_p.S75_splice	NM_000978.3	NP_000969.1	P62829	RL23_HUMAN	ribosomal protein L23	75					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			endometrium(2)|large_intestine(1)	3						TTTACTCACCCTTTTTTCTGAG	0.485													7	619	---	---	---	---					
STAC2	342667	broad.mit.edu	37	17	37373352	37373353	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:37373352_37373353insA	ENST00000333461.5	-	3	840_841	c.471_472insT	c.(469-474)tcaccafs	p.P158fs		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	158					intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						CATTGCTGGTGGGAGATCTCCT	0.550													12	120	---	---	---	---					
SMARCE1	6605	broad.mit.edu	37	17	38787144	38787145	+	In_Frame_Ins	INS	-	-	ACT			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:38787144_38787145insACT	ENST00000348513.6	-	10	1628_1629	c.848_849insAGT	c.(847-849)gaa>gAGTaa	p.283_284ins*	KRT222_ENST00000476049.1_3'UTR|SMARCE1_ENST00000580419.1_In_Frame_Ins_p.248_249ins*|SMARCE1_ENST00000544009.1_In_Frame_Ins_p.213_214ins*|SMARCE1_ENST00000578044.1_In_Frame_Ins_p.213_214ins*|SMARCE1_ENST00000400122.3_In_Frame_Ins_p.213_214ins*|SMARCE1_ENST00000377808.4_In_Frame_Ins_p.248_249ins*|SMARCE1_ENST00000431889.2_In_Frame_Ins_p.265_266ins*	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	283					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				CTGCAATTTTCTCCATATCCAC	0.450													10	189	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													10	128	---	---	---	---					
STAT5A	6776	broad.mit.edu	37	17	40453398	40453399	+	Frame_Shift_Ins	INS	-	-	C	rs146398782		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:40453398_40453399insC	ENST00000345506.4	+	10	1737_1738	c.1095_1096insC	c.(1093-1098)aaccccfs	p.NP365fs	STAT5A_ENST00000590949.1_Frame_Shift_Ins_p.NP365fs|STAT5A_ENST00000546010.2_Frame_Shift_Ins_p.NP335fs|STAT5A_ENST00000452307.2_Frame_Shift_Ins_p.NP365fs|STAT5A_ENST00000588868.1_Frame_Shift_Ins_p.NP365fs	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	365					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		TGCACATGAATCCCCCCCAGGT	0.564													13	394	---	---	---	---					
ARL4D	379	broad.mit.edu	37	17	41477331	41477332	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:41477331_41477332insG	ENST00000320033.4	+	2	438_439	c.231_232insG	c.(229-234)gtggggfs	p.VG77fs		NM_001661.3	NP_001652.2	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	77					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TGTGGGACGTCGGGGGGCAGGA	0.629													17	502	---	---	---	---					
ETV4	2118	broad.mit.edu	37	17	41610700	41610701	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:41610700_41610701insG	ENST00000319349.5	-	7	697_698	c.399_400insC	c.(397-402)ccgacafs	p.T134fs	ETV4_ENST00000538265.1_Frame_Shift_Ins_p.T95fs|ETV4_ENST00000591713.1_Frame_Shift_Ins_p.T134fs|ETV4_ENST00000545954.1_Frame_Shift_Ins_p.T95fs|ETV4_ENST00000545089.1_Intron|ETV4_ENST00000393664.2_Frame_Shift_Ins_p.T134fs	NM_001079675.2	NP_001073143.1	P43268	ETV4_HUMAN	ets variant 4	134					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)|CANT1/ETV4(3)|TMPRSS2/ETV4(13)|DDX5_ENST00000540698/ETV4(2)|KLK2/ETV4(2)	ovary(2)|upper_aerodigestive_tract(1)	3		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		GCGATTTGTCTGGGGGGGTCAT	0.579			T	"""EWSR1, TMPRSS2, DDX5, KLK2, CANT1"""	"""Ewing sarcoma, Prostate carcinoma"""								8	73	---	---	---	---					
GPATCH8	23131	broad.mit.edu	37	17	42478248	42478249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:42478248_42478249insG	ENST00000434000.1	-	9	1244_1245	c.962_963insC	c.(961-963)cgcfs	p.R321fs	GPATCH8_ENST00000591680.1_Frame_Shift_Ins_p.R399fs			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	399						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGCAGTGTGCTGGGGGGATGTA	0.441											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	396	---	---	---	---					
OSBPL7	114881	broad.mit.edu	37	17	45886342	45886343	+	Frame_Shift_Ins	INS	-	-	G	rs143462261		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:45886342_45886343insG	ENST00000007414.3	-	21	2375_2376	c.2184_2185insC	c.(2182-2187)ccaccafs	p.P729fs	OSBPL7_ENST00000392507.3_Frame_Shift_Ins_p.P729fs	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	729					lipid transport		lipid binding	p.D729fs*3(1)		autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						CGCTCATGGTCGGGGGGCATTG	0.619													9	284	---	---	---	---					
MRPL27	51264	broad.mit.edu	37	17	48447367	48447368	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:48447367_48447368insG	ENST00000442592.3	-	3	301_302	c.265_266insC	c.(265-267)tttfs	p.F89fs	MRPL27_ENST00000503633.1_Intron|MRPL27_ENST00000511860.1_Intron|MRPL27_ENST00000507088.1_Intron|MRPL27_ENST00000225969.4_Intron			Q9P0M9	RM27_HUMAN	mitochondrial ribosomal protein L27	0					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			endometrium(1)|large_intestine(2)|urinary_tract(1)	4	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;1.73e-07)			AAAAGGAAAAAGGGGGGCAGCA	0.495													17	1016	---	---	---	---					
MTMR4	9110	broad.mit.edu	37	17	56590245	56590246	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:56590245_56590246insG	ENST00000323456.5	-	3	184_185	c.60_61insC	c.(58-63)ccaggafs	p.G21fs	MTMR4_ENST00000579925.1_Frame_Shift_Ins_p.G21fs	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	21						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity	p.K21fs*20(1)		breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTAGTTCCTTGGGGGGGAACA	0.569													40	1013	---	---	---	---					
CLTC	1213	broad.mit.edu	37	17	57733326	57733327	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:57733326_57733327insT	ENST00000269122.3	+	6	1181_1182	c.907_908insT	c.(907-909)tttfs	p.F303fs	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Frame_Shift_Ins_p.F303fs	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	303	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGGAGAAACAATTTTTGTTACT	0.371			T	"""ALK, TFE3"""	"""ALCL, renal """								222	155	---	---	---	---					
MARCH10	162333	broad.mit.edu	37	17	60814265	60814266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:60814265_60814266insC	ENST00000544856.2	-	7	1338_1339	c.960_961insG	c.(958-963)ggcatcfs	p.I321fs	RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Frame_Shift_Ins_p.I322fs|MARCH10_ENST00000583600.1_Frame_Shift_Ins_p.I360fs|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000311269.5_Frame_Shift_Ins_p.I322fs			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	322							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						GGGGTCGATGTCCCCCCAAATC	0.460													7	1117	---	---	---	---					
ACE	1636	broad.mit.edu	37	17	61559936	61559937	+	Frame_Shift_Ins	INS	-	-	G	rs145172277	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:61559936_61559937insG	ENST00000290866.4	+	8	1252_1253	c.1228_1229insG	c.(1228-1230)gggfs	p.G410fs	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Frame_Shift_Ins_p.G410fs|ACE_ENST00000538928.1_Frame_Shift_Ins_p.G410fs	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	410	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CTCCCTGCGTCGGGGGGCCAAC	0.609													7	258	---	---	---	---					
SCN4A	6329	broad.mit.edu	37	17	62049212	62049213	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:62049212_62049213insG	ENST00000578147.1	-	4	559		c.e4-2		SCN4A_ENST00000435607.1_Splice_Site			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit						muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AAGGTGTACCTGGGGGGGAGAG	0.589													8	122	---	---	---	---					
PRKCA	5578	broad.mit.edu	37	17	64683327	64683328	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:64683327_64683328insA	ENST00000413366.3	+	6	654_655	c.628_629insA	c.(628-630)aaafs	p.K210fs		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	210	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	TGAAAGCAAGCAAAAAACCAAA	0.401													9	370	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:67083603_67083604insG	ENST00000284425.2	-	29	3883_3884	c.3709_3710insC	c.(3709-3711)aagfs	p.K1237fs	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376													14	757	---	---	---	---					
FAM104A	84923	broad.mit.edu	37	17	71223356	71223357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:71223356_71223357insG	ENST00000405159.3	-	2	332_333	c.268_269insC	c.(268-270)gacfs	p.D90fs	FAM104A_ENST00000581110.1_Intron|FAM104A_ENST00000580032.1_5'UTR|FAM104A_ENST00000403627.3_Frame_Shift_Ins_p.D90fs|FAM104A_ENST00000583178.1_5'UTR|FAM104A_ENST00000583024.1_Intron	NM_001098832.1	NP_001092302.1	Q969W3	F104A_HUMAN	family with sequence similarity 104, member A	90										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			LUSC - Lung squamous cell carcinoma(166;0.197)			TCTTTTGGTCTGGGGGGGAAGA	0.416													21	258	---	---	---	---					
MRPS7	51081	broad.mit.edu	37	17	73258564	73258565	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:73258564_73258565insC	ENST00000579002.1	+	1	572_573	c.157_158insC	c.(157-159)cccfs	p.P53fs	MRPS7_ENST00000579761.1_Intron|MRPS7_ENST00000245539.6_Intron			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	0					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CCTCCTCCTTTCCCCCCCTCCC	0.554													22	627	---	---	---	---					
KIAA0195	9772	broad.mit.edu	37	17	73493880	73493881	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:73493880_73493881insC	ENST00000314256.7	+	27	3820_3821	c.3426_3427insC	c.(3424-3429)aaccccfs	p.NP1142fs	KIAA0195_ENST00000579208.1_Frame_Shift_Ins_p.NP793fs|KIAA0195_ENST00000375248.5_Frame_Shift_Ins_p.NP1152fs	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1142					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGCTGGGGAAGCCCCCCCATAG	0.520													89	2207	---	---	---	---					
TBCD	6904	broad.mit.edu	37	17	80758858	80758860	+	Translation_Start_Site	DEL	GGT	GGT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr17:80758858_80758860delGGT	ENST00000397466.2	+	0	1045_1047				TBCD_ENST00000539345.2_In_Frame_Del_p.KV312del|TBCD_ENST00000355528.4_In_Frame_Del_p.KV312del			Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TGAAGCCGAAGGTGGCAGCATGG	0.675													7	36	---	---	---	---					
CEP192	55125	broad.mit.edu	37	18	13113612	13113613	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr18:13113612_13113613insG	ENST00000506447.1	+	41	7155_7156	c.7075_7076insG	c.(7075-7077)gggfs	p.G2359fs	CEP192_ENST00000325971.8_Frame_Shift_Ins_p.G1763fs|CEP192_ENST00000430049.2_Frame_Shift_Ins_p.G1884fs|CEP192_ENST00000540847.2_3'UTR	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1954										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCCCAGAGGTAGGGGGGATTAT	0.426													7	309	---	---	---	---					
TRAPPC8	22878	broad.mit.edu	37	18	29437545	29437546	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr18:29437545_29437546insGG	ENST00000283351.4	-	20	3480_3481	c.3145_3146insCC	c.(3145-3147)tttfs	p.F1049fs	TRAPPC8_ENST00000582539.1_Frame_Shift_Ins_p.F995fs	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	1049					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GTAAAACAAAAAGTTAATTTCA	0.376													19	149	---	---	---	---					
ZBTB7C	201501	broad.mit.edu	37	18	45567084	45567085	+	Frame_Shift_Ins	INS	-	-	C	rs115080210	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr18:45567084_45567085insC	ENST00000588982.1	-	3	895_896	c.394_395insG	c.(394-396)cggfs	p.R132fs	ZBTB7C_ENST00000535628.2_Frame_Shift_Ins_p.R132fs|ZBTB7C_ENST00000590800.1_Frame_Shift_Ins_p.R132fs|ZBTB7C_ENST00000332053.2_Frame_Shift_Ins_p.R132fs|ZBTB7C_ENST00000586438.1_Frame_Shift_Ins_p.R132fs			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	132	Asp-rich.|Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						ctcccccccgtcccccCCAGGC	0.579													8	225	---	---	---	---					
ATP8B1	5205	broad.mit.edu	37	18	55317669	55317669	+	Frame_Shift_Del	DEL	G	G	-	rs112600442		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr18:55317669delG	ENST00000536015.1	-	27	3580	c.3461delC	c.(3460-3462)gtfs	p.A1154fs	ATP8B1_ENST00000283684.4_Frame_Shift_Del_p.A1154fs|RP11-35G9.3_ENST00000591854.1_RNA|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA|RP11-35G9.3_ENST00000592201.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	1154					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TAAGCACACAGCAACAGCCAG	0.433													21	400	---	---	---	---					
LRG1	116844	broad.mit.edu	37	19	4538452	4538453	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:4538452_4538453insG	ENST00000306390.6	-	2	1003_1004	c.543_544insC	c.(541-546)ccggctfs	p.A182fs	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	182						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCAGCCCGGGGGGCAGTT	0.619													9	369	---	---	---	---					
ZNRF4	148066	broad.mit.edu	37	19	5456529	5456530	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:5456529_5456530insC	ENST00000222033.4	+	1	1104_1105	c.1027_1028insC	c.(1027-1029)cccfs	p.P343fs		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	343						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTTCTCCCAAGCCCCCCGGCGC	0.609													7	210	---	---	---	---					
C3	718	broad.mit.edu	37	19	6697480	6697481	+	Frame_Shift_Ins	INS	-	-	G	rs137956083		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:6697480_6697481insG	ENST00000245907.6	-	21	2762_2763	c.2670_2671insC	c.(2668-2673)ccagtcfs	p.V891fs		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	891					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AACGAGGACTTGGGGGGGATGG	0.574													54	1107	---	---	---	---					
SH2D3A	10045	broad.mit.edu	37	19	6755179	6755180	+	Frame_Shift_Ins	INS	-	-	G	rs139813452	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:6755179_6755180insG	ENST00000245908.6	-	5	912_913	c.643_644insC	c.(643-645)gacfs	p.D215fs	SH2D3A_ENST00000599563.1_5'UTR|SH2D3A_ENST00000437152.3_Frame_Shift_Ins_p.D93fs	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	215					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GGAGGGTGTCCGGGGGGGCTTC	0.653													21	454	---	---	---	---					
FBN3	84467	broad.mit.edu	37	19	8196624	8196625	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:8196624_8196625insC	ENST00000600128.1	-	15	2217_2218	c.1803_1804insG	c.(1801-1806)ggtggcfs	p.G602fs	FBN3_ENST00000601739.1_Frame_Shift_Ins_p.G602fs|FBN3_ENST00000270509.2_Frame_Shift_Ins_p.G602fs			Q75N90	FBN3_HUMAN	fibrillin 3	602	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCTACCGCCAGCCCCCCCAGGC	0.678													10	87	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9059338	9059339	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:9059338_9059339insG	ENST00000397910.4	-	3	28310_28311	c.28107_28108insC	c.(28105-28110)ccaaacfs	p.N9370fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9372	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACCTGTTTTGGGGGTGATGG	0.505													8	400	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064309	9064310	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:9064309_9064310insG	ENST00000397910.4	-	3	23339_23340	c.23136_23137insC	c.(23134-23139)ccctccfs	p.S7713fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGGGAGAGGGGGGGATAT	0.530													20	394	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9072450	9072451	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:9072450_9072451insG	ENST00000397910.4	-	3	15198_15199	c.14995_14996insC	c.(14995-14997)ggcfs	p.G4999fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5001	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATCCCTGCCTGGGGGGTTGTA	0.465													9	390	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10291083	10291084	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:10291083_10291084insG	ENST00000340748.4	-	4	622_623	c.387_388insC	c.(385-390)ccaaccfs	p.T130fs	DNMT1_ENST00000359526.4_Frame_Shift_Ins_p.T130fs|DNMT1_ENST00000540357.1_Frame_Shift_Ins_p.T130fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	130	Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GAAAGGGGTTTGGGGGGGCTGT	0.495													46	650	---	---	---	---					
EPOR	2057	broad.mit.edu	37	19	11488680	11488681	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:11488680_11488681insG	ENST00000222139.6	-	8	1610_1611	c.1506_1507insC	c.(1504-1509)ccgctafs	p.L503fs	EPOR_ENST00000592375.2_3'UTR	NM_000121.3	NP_000112.1	P19235	EPOR_HUMAN	erythropoietin receptor	503						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GCCACATAGCTGGGGGGCAGAG	0.569											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	696	---	---	---	---					
ZNF625	90589	broad.mit.edu	37	19	12256750	12256751	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:12256750_12256751insC	ENST00000355738.1	-	4	631_632	c.282_283insG	c.(280-285)ggaaccfs	p.T95fs	ZNF625-ZNF20_ENST00000430024.1_Intron|ZNF625_ENST00000439556.2_Frame_Shift_Ins_p.T161fs|ZNF625_ENST00000542938.1_Frame_Shift_Ins_p.T95fs|ZNF625_ENST00000455799.1_3'UTR			Q96I27	ZN625_HUMAN	zinc finger protein 625	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						TCATAAGGTTTCCCCCCAGTGT	0.421													10	1011	---	---	---	---					
TNPO2	30000	broad.mit.edu	37	19	12812575	12812576	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:12812575_12812576insC	ENST00000425528.1	-	23	2858_2859	c.2501_2502insG	c.(2500-2502)ggtfs	p.G834fs	TNPO2_ENST00000592287.1_Frame_Shift_Ins_p.G834fs|TNPO2_ENST00000356861.5_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000588216.1_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000441499.1_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000450764.2_Frame_Shift_Ins_p.G824fs			O14787	TNPO2_HUMAN	transportin 2	834					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTGCACAACGCCCCCCGGGTT	0.639													10	295	---	---	---	---					
IL27RA	9466	broad.mit.edu	37	19	14157253	14157254	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:14157253_14157254insC	ENST00000263379.2	+	8	1089_1090	c.964_965insC	c.(964-966)cccfs	p.P322fs		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	322	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity	p.R324fs*2(1)		breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						TTCAGCCTCTGCCCCCCGTAGC	0.629													7	516	---	---	---	---					
SLC1A6	6511	broad.mit.edu	37	19	15067446	15067447	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:15067446_15067447insC	ENST00000430939.2	-	6	947_948	c.818_819insG	c.(817-819)gcafs	p.A273fs	SLC1A6_ENST00000221742.3_Frame_Shift_Ins_p.A337fs|SLC1A6_ENST00000600144.1_Intron			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	337					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	TGCCCAGCTGACCCCCCAGGAC	0.584													7	976	---	---	---	---					
AP1M1	8907	broad.mit.edu	37	19	16314383	16314384	+	Frame_Shift_Ins	INS	-	-	G	rs146546344	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:16314383_16314384insG	ENST00000291439.3	+	2	605_606	c.156_157insG	c.(154-159)caggggfs	p.QG52fs	AP1M1_ENST00000541844.1_Intron|AP1M1_ENST00000444449.2_Frame_Shift_Ins_p.QG52fs|AP1M1_ENST00000590756.1_Intron|AP1M1_ENST00000429941.2_Frame_Shift_Ins_p.QG52fs	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	52					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TCCTGGCCCACGGGGGGGTCCG	0.594													11	371	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17039883	17039884	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:17039883_17039884insC	ENST00000443236.1	-	24	3184_3185	c.3153_3154insG	c.(3151-3156)ggatcafs	p.S1052fs		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1005						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.H1052fs*30(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GTGTTCTGATGCCCCCCCAGGA	0.584													11	160	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17081702	17081703	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:17081702_17081703insG	ENST00000443236.1	-	18	2383_2384	c.2354_splice	c.e18+1	p.N785_splice	CPAMD8_ENST00000388925.4_3'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	738						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AGCCGTTACCTGGGGGGGTGCC	0.569													7	56	---	---	---	---					
PLVAP	83483	broad.mit.edu	37	19	17488050	17488051	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:17488050_17488051insC	ENST00000252590.4	-	1	108_109	c.47_48insG	c.(46-48)gagfs	p.E16fs		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	16						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCCGAGAGCTGCCCCCCGCCCG	0.624													8	375	---	---	---	---					
LRRC25	126364	broad.mit.edu	37	19	18502937	18502938	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:18502937_18502938insG	ENST00000339007.3	-	2	1433		c.e2-2		LRRC25_ENST00000595840.1_Splice_Site	NM_145256.2	NP_660299.2	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25							integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						GGGTGAGCCCTGGGGGGACAGA	0.574													10	974	---	---	---	---					
ZNF536	9745	broad.mit.edu	37	19	31039041	31039042	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:31039041_31039042insG	ENST00000355537.3	+	4	2662_2663	c.2515_2516insG	c.(2515-2517)gggfs	p.G839fs		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	839					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGACATCCTGAGGGGGGCCTTC	0.584													8	436	---	---	---	---					
HAUS5	23354	broad.mit.edu	37	19	36113838	36113840	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:36113838_36113840delCCA	ENST00000203166.5	+	19	1870_1872	c.1845_1847delCCA	c.(1843-1848)ccg>cc	p.PQ615del	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	615					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						TGTCCCTGCCCCAGTGGCGGCTG	0.655													13	121	---	---	---	---					
HCST	10870	broad.mit.edu	37	19	36393526	36393527	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:36393526_36393527insT	ENST00000246551.4	+	1	145_146	c.31_32insT	c.(31-33)tttfs	p.F11fs	HCST_ENST00000437550.2_Frame_Shift_Ins_p.F11fs			Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer	11					regulation of immune response	integral to membrane|plasma membrane				lung(4)	4	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCTTCCTGCTTTTGCTCCCA	0.584													9	1375	---	---	---	---					
DYRK1B	9149	broad.mit.edu	37	19	40320998	40320999	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:40320998_40320999insG	ENST00000601972.1	-	4	618_619	c.388_389insC	c.(388-390)ccafs	p.P130fs	DYRK1B_ENST00000348817.3_Intron|DYRK1B_ENST00000430012.2_Intron|DYRK1B_ENST00000597639.1_Intron|DYRK1B_ENST00000593685.1_Intron|DYRK1B_ENST00000323039.5_Intron			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	578	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			ATCAGGGTGGTGGGGGGTGTCC	0.584													7	263	---	---	---	---					
FBL	2091	broad.mit.edu	37	19	40325192	40325193	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:40325192_40325193insG	ENST00000221801.3	-	9	1064_1065	c.951_952insC	c.(949-954)ccaggtfs	p.G318fs	FBL_ENST00000593503.1_5'UTR	NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	318					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TTCTTCACCTTGGGGGGTGGCC	0.505													18	759	---	---	---	---					
FCGBP	8857	broad.mit.edu	37	19	40433028	40433028	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:40433028delC	ENST00000221347.6	-	2	1248	c.1241delG	c.(1240-1242)gafs	p.G414fs		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	414	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGTGAGCAGTCCCAAGTTGGT	0.597													19	187	---	---	---	---					
LTBP4	8425	broad.mit.edu	37	19	41132910	41132911	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:41132910_41132911insC	ENST00000308370.7	+	32	4214_4215	c.4214_4215insC	c.(4213-4215)cccfs	p.P1405fs	LTBP4_ENST00000396819.3_Frame_Shift_Ins_p.P1338fs|LTBP4_ENST00000545697.1_Frame_Shift_Ins_p.P773fs|LTBP4_ENST00000204005.9_Frame_Shift_Ins_p.P1368fs|LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000602240.1_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1406					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AATGTGCTACGCCCCCCCGCAT	0.629													8	98	---	---	---	---					
CEACAM5	1048	broad.mit.edu	37	19	42224865	42224866	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:42224865_42224866insC	ENST00000221992.6	+	8	1909_1910	c.1795_1796insC	c.(1795-1797)cccfs	p.P599fs	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Frame_Shift_Ins_p.P599fs|CEACAM5_ENST00000398599.4_Frame_Shift_Ins_p.P598fs	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	599	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCCCATCATTTCCCCCCCAGAC	0.545													12	341	---	---	---	---					
POU2F2	5452	broad.mit.edu	37	19	42621520	42621521	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:42621520_42621521insG	ENST00000560398.1	-	5	257_258	c.250_251insC	c.(250-252)gatfs	p.D84fs	POU2F2_ENST00000526816.2_Splice_Site|POU2F2_ENST00000389341.5_Splice_Site|POU2F2_ENST00000529067.1_Splice_Site|POU2F2_ENST00000533720.1_Splice_Site|POU2F2_ENST00000342301.4_Splice_Site|POU2F2_ENST00000560558.1_Intron|POU2F2_ENST00000529952.1_Splice_Site|POU2F2_ENST00000524801.2_Splice_Site			P09086	PO2F2_HUMAN	POU class 2 homeobox 2	62					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				AGCCTTGATCTGGGGGGGAGAG	0.634													13	225	---	---	---	---					
PSG7	5676	broad.mit.edu	37	19	43439519	43439520	+	RNA	INS	-	-	C	rs59911953	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:43439519_43439520insC	ENST00000406070.2	-	0	527				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				AATGACCCCTGCCCCCCAACAC	0.515													19	972	---	---	---	---					
MARK4	57787	broad.mit.edu	37	19	45805663	45805664	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:45805663_45805664insC	ENST00000300843.4	+	18	2331_2332	c.2034_2035insC	c.(2032-2037)ccccccfs	p.PP678fs	MARK4_ENST00000262891.4_Frame_Shift_Ins_p.P652fs	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	0					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACGGAAACCGCCCCCCGGCTG	0.639													10	286	---	---	---	---					
IGFL2	147920	broad.mit.edu	37	19	46663998	46663999	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:46663998_46663999insC	ENST00000434646.2	+	4	525_526	c.234_235insC	c.(232-237)ggccccfs	p.GP78fs	IGFL2_ENST00000377693.4_Frame_Shift_Ins_p.GP67fs|AC007193.6_ENST00000597989.1_lincRNA|IGFL2_ENST00000600243.1_3'UTR	NM_001002915.2	NP_001002915.2	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2	67						extracellular region	protein binding			cervix(1)|lung(5)	6		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		GCCAATGTGGTCCCCCCTGCAC	0.554													11	1575	---	---	---	---					
EHD2	30846	broad.mit.edu	37	19	48244286	48244287	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:48244286_48244287insG	ENST00000263277.3	+	6	1480_1481	c.1229_1230insG	c.(1228-1230)cggfs	p.R410fs	EHD2_ENST00000538399.1_Frame_Shift_Ins_p.R274fs|EHD2_ENST00000540884.1_3'UTR	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	410					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GTGGGCGTGCAGGGGGGCGCTT	0.673													8	271	---	---	---	---					
CARD8	22900	broad.mit.edu	37	19	48737669	48737670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:48737669_48737670insC	ENST00000391898.3	-	3	382_383	c.340_341insG	c.(340-342)catfs	p.H114fs	CARD8_ENST00000519940.1_Frame_Shift_Ins_p.H114fs|CARD8_ENST00000359009.4_Frame_Shift_Ins_p.I23fs|CARD8_ENST00000520015.1_Frame_Shift_Ins_p.H114fs|CARD8_ENST00000357778.5_5'UTR|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000520153.1_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000447740.2_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000521613.1_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000520753.1_Frame_Shift_Ins_p.H114fs	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	0					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		CCTGGGAATGTCCCCCCCAGAT	0.436													17	264	---	---	---	---					
SLC6A16	28968	broad.mit.edu	37	19	49813085	49813086	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:49813085_49813086insG	ENST00000454748.3	-	5	902		c.e5-2		SLC6A16_ENST00000335875.4_Splice_Site			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16							integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		ATTCAGGATCTGGGGGGACCTG	0.535													14	811	---	---	---	---					
CPT1C	126129	broad.mit.edu	37	19	50216300	50216301	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:50216300_50216301insA	ENST00000392518.4	+	19	2577_2578	c.2205_2206insA	c.(2203-2208)agaaaafs	p.RK735fs	CPT1C_ENST00000354199.5_Frame_Shift_Ins_p.RK646fs|CPT1C_ENST00000323446.5_Frame_Shift_Ins_p.RK735fs|CPT1C_ENST00000405931.2_Frame_Shift_Ins_p.RK724fs|CPT1C_ENST00000598293.1_Frame_Shift_Ins_p.RK735fs	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	735					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		ACATCTCCAGCAAAAAATCAAG	0.505													8	1054	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243063	50243064	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:50243063_50243064insG	ENST00000246801.3	-	11	1830_1831	c.1748_1749insC	c.(1747-1749)caafs	p.Q583fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.Q383fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	583							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCCTGTTTTGGGGGGGTTCC	0.545													21	449	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243087	50243088	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:50243087_50243088insC	ENST00000246801.3	-	11	1806_1807	c.1724_1725insG	c.(1723-1725)gggfs	p.G575fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.G375fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	575							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CACTGCTGCCTCCCCCCATTGT	0.554													10	572	---	---	---	---					
NAPSA	9476	broad.mit.edu	37	19	50862305	50862306	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:50862305_50862306insC	ENST00000253719.2	-	8	1205_1206	c.997_998insG	c.(997-999)ctgfs	p.L333fs	NR1H2_ENST00000600978.1_Intron|NR1H2_ENST00000542413.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	333					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GTTAAACCAGACCCCCCCAAGA	0.530													22	524	---	---	---	---					
POLD1	5424	broad.mit.edu	37	19	50905323	50905324	+	Frame_Shift_Ins	INS	-	-	G	rs140707092		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:50905323_50905324insG	ENST00000440232.2	+	5	584_585	c.531_532insG	c.(529-534)cgggggfs	p.RG177fs	POLD1_ENST00000595904.1_Frame_Shift_Ins_p.RG177fs|POLD1_ENST00000599857.1_Frame_Shift_Ins_p.RG177fs	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	177			R -> H (in dbSNP:rs3218750).		base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding	p.R177R(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GGGACAGTCGCGGGGGGAGGGA	0.673								DNA polymerases (catalytic subunits)					7	79	---	---	---	---					
SHANK1	50944	broad.mit.edu	37	19	51192459	51192460	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:51192459_51192460insC	ENST00000293441.1	-	15	2059_2060	c.2041_2042insG	c.(2041-2043)caafs	p.Q681fs	SHANK1_ENST00000391813.1_Frame_Shift_Ins_p.Q68fs|SHANK1_ENST00000391814.1_Frame_Shift_Ins_p.Q681fs|SHANK1_ENST00000359082.3_Frame_Shift_Ins_p.Q672fs	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	681	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding	p.A681S(1)		breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTCACCCTTGGCCCCCCGGAGC	0.609													7	332	---	---	---	---					
GPR32	2854	broad.mit.edu	37	19	51274914	51274915	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:51274914_51274915insC	ENST00000270590.4	+	1	1194_1195	c.1057_1058insC	c.(1057-1059)cccfs	p.P353fs		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	353						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCGTGGCAACGCCCCCCGGGAA	0.525													12	347	---	---	---	---					
LIM2	3982	broad.mit.edu	37	19	51890511	51890512	+	Frame_Shift_Ins	INS	-	-	G	rs73933350	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:51890511_51890512insG	ENST00000221973.3	-	2	228_229	c.186_187insC	c.(184-189)ccgccafs	p.P63fs	LIM2_ENST00000596399.1_Intron	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	58					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		GGACCCTGGCCGGGGGGCTCAC	0.649													8	90	---	---	---	---					
ZNF528	84436	broad.mit.edu	37	19	52919519	52919519	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:52919519delA	ENST00000360465.3	+	7	1840	c.1414delA	c.(1414-1416)aafs	p.K472fs	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AGAATGTGGCAAAGTCTTCAG	0.398													9	358	---	---	---	---					
CNOT3	4849	broad.mit.edu	37	19	54649666	54649667	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:54649666_54649667insC	ENST00000406403.1	+	8	2327_2328	c.724_725insC	c.(724-726)cccfs	p.P242fs	CNOT3_ENST00000221232.5_Frame_Shift_Ins_p.P242fs|CNOT3_ENST00000358389.3_Frame_Shift_Ins_p.P61fs			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	242					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGTCGCCACCTCCCCTCCCAGC	0.644													7	94	---	---	---	---					
KIR3DL1	3811	broad.mit.edu	37	19	55341655	55341656	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr19:55341655_55341656insC	ENST00000391728.4	+	9	1293_1294	c.1260_1261insC	c.(1258-1263)acccccfs	p.TP420fs	KIR3DL1_ENST00000541392.1_Frame_Shift_Ins_p.TP403fs|KIR3DL1_ENST00000538269.1_Frame_Shift_Ins_p.TP420fs|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000326542.7_Frame_Shift_Ins_p.TP403fs|KIR3DL1_ENST00000358178.4_Frame_Shift_Ins_p.TP325fs	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		GGCCCAAGACACCCCCTACAGA	0.510													7	1749	---	---	---	---					
DEFB132	400830	broad.mit.edu	37	20	239780	239781	+	Frame_Shift_Ins	INS	-	-	G	rs138201035	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:239780_239781insG	ENST00000382376.3	+	2	164_165	c.121_122insG	c.(121-123)gggfs	p.G41fs		NM_207469.2	NP_997352.1	Q7Z7B7	DB132_HUMAN	defensin, beta 132	41					defense response to bacterium	extracellular region				breast(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	4						ATGTTGCCACTGGGGGGAGACA	0.525													9	252	---	---	---	---					
NRSN2	80023	broad.mit.edu	37	20	333922	333923	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:333922_333923insC	ENST00000382291.3	+	4	498_499	c.258_259insC	c.(256-261)gtccccfs	p.VP86fs	NRSN2_ENST00000382285.2_Frame_Shift_Ins_p.VP86fs|NRSN2_ENST00000492242.1_3'UTR	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	86						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				GCTATGCAGTGCCCCCCAAGCT	0.644													13	448	---	---	---	---					
RSPO4	343637	broad.mit.edu	37	20	948762	948763	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:948762_948763insC	ENST00000217260.4	-	2	194_195	c.98_99insG	c.(97-99)gaafs	p.E33fs	RSPO4_ENST00000400634.2_Frame_Shift_Ins_p.E33fs	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	33					Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						CTGTGCAGTTGCCCCCCAGGCC	0.594													10	718	---	---	---	---					
NSFL1C	55968	broad.mit.edu	37	20	1426464	1426465	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:1426464_1426465insG	ENST00000216879.4	-	8	1663_1664	c.796_797insC	c.(796-798)ggtfs	p.G266fs	NSFL1C_ENST00000350991.4_Frame_Shift_Ins_p.G268fs|NSFL1C_ENST00000461211.1_5'UTR|NSFL1C_ENST00000353088.2_Frame_Shift_Ins_p.G235fs|NSFL1C_ENST00000476071.1_Frame_Shift_Ins_p.G268fs|NSFL1C_ENST00000381658.4_Frame_Shift_Ins_p.G155fs	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	266						chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						ACTCAACACCTGGGGGGCAGTG	0.510													13	474	---	---	---	---					
FASTKD5	60493	broad.mit.edu	37	20	3128000	3128001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:3128000_3128001insC	ENST00000380266.3	-	2	2037_2038	c.1716_1717insG	c.(1714-1719)ggcccafs	p.GP572fs	UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	572					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						ACGTACTGGGGCCCCCCCAGCA	0.436													8	205	---	---	---	---					
ISM1	140862	broad.mit.edu	37	20	13260474	13260475	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:13260474_13260475insC	ENST00000262487.3	+	3	578_579	c.572_573insC	c.(571-573)accfs	p.T191fs	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	191						extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						AACTTCCTCAACCCCCCCAGGG	0.554													14	307	---	---	---	---					
PLAGL2	5326	broad.mit.edu	37	20	30789951	30789952	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:30789951_30789952insG	ENST00000246229.4	-	2	294_295	c.30_31insC	c.(28-33)ccggatfs	p.D11fs		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	11						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCTTGAATCCAGGGGGGGACGC	0.559													10	170	---	---	---	---					
CNBD2	140894	broad.mit.edu	37	20	34618503	34618504	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:34618503_34618504insC	ENST00000373973.3	+	12	1837_1838	c.1664_1665insC	c.(1663-1665)cccfs	p.P555fs	CNBD2_ENST00000538900.1_3'UTR|CNBD2_ENST00000349339.1_Frame_Shift_Ins_p.P551fs					cyclic nucleotide binding domain containing 2																		CAGAAATACCTCCCCCCATTGA	0.455													12	1009	---	---	---	---					
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:37146232_37146233insC	ENST00000262879.6	+	8	1419_1420	c.1135_1136insC	c.(1135-1137)cccfs	p.P379fs	RALGAPB_ENST00000397040.1_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000397038.1_Frame_Shift_Ins_p.P157fs|RALGAPB_ENST00000397042.3_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000537204.1_Frame_Shift_Ins_p.P379fs			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.H382fs*2(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAGTACCACCCCCCCACAT	0.446													7	107	---	---	---	---					
LPIN3	64900	broad.mit.edu	37	20	39977798	39977799	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:39977798_39977799insC	ENST00000373257.3	+	5	715_716	c.624_625insC	c.(622-627)tgccccfs	p.CP208fs		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	208					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ATGGCGAGTGGCCCCCCCAGGC	0.540													11	151	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)ccatttfs	p.F103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													19	272	---	---	---	---					
WFDC3	140686	broad.mit.edu	37	20	44404105	44404106	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:44404105_44404106insG	ENST00000243938.4	-	6	712_713	c.629_630insC	c.(628-630)caafs	p.Q210fs	WFDC3_ENST00000372630.2_Frame_Shift_Ins_p.Q73fs|WFDC3_ENST00000481847.1_5'UTR|WFDC3_ENST00000372632.2_Frame_Shift_Ins_p.Q116fs	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	210						extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				TGGTCAGTTTTGGGGGCAGGAC	0.480													9	889	---	---	---	---					
NCOA5	57727	broad.mit.edu	37	20	44691403	44691404	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:44691403_44691404insG	ENST00000290231.6	-	8	1439_1440	c.1275_1276insC	c.(1273-1278)cccctcfs	p.L426fs		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TGCTGGGAGGTGGGGGGTGCAG	0.619													9	513	---	---	---	---					
SLC13A3	64849	broad.mit.edu	37	20	45194969	45194970	+	Frame_Shift_Ins	INS	-	-	G	rs149123701	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:45194969_45194970insG	ENST00000279027.4	-	11	1410_1411	c.1392_1393insC	c.(1390-1395)ccccctfs	p.PP464fs	SLC13A3_ENST00000290317.5_Frame_Shift_Ins_p.PP417fs|SLC13A3_ENST00000435032.1_Frame_Shift_Ins_p.PP49fs|SLC13A3_ENST00000495082.1_Frame_Shift_Ins_p.PP417fs|SLC13A3_ENST00000396360.1_Frame_Shift_Ins_p.PP382fs|SLC13A3_ENST00000472148.1_Frame_Shift_Ins_p.PP382fs|SLC13A3_ENST00000413164.2_Frame_Shift_Ins_p.PP414fs	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	464						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity	p.P464P(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	ACAGCCAGGGCGGGGGGCACAT	0.604													20	865	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:47989771_47989772insG	ENST00000371741.4	-	2	2491_2492	c.2325_2326insC	c.(2323-2328)ccaaagfs	p.PK775fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	775					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545													37	775	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989890	47989891	+	Frame_Shift_Ins	INS	-	-	G	rs151175979	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:47989890_47989891insG	ENST00000371741.4	-	2	2372_2373	c.2206_2207insC	c.(2206-2208)gtcfs	p.V736fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	736					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTCAGGAGACCGGGGGGGTGTC	0.559													8	142	---	---	---	---					
MOCS3	27304	broad.mit.edu	37	20	49576707	49576708	+	Frame_Shift_Ins	INS	-	-	G	rs142791519		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:49576707_49576708insG	ENST00000244051.1	+	1	1345_1346	c.1328_1329insG	c.(1327-1329)gggfs	p.G443fs		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	443	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						CGGGATGTTGTGGGGGGCCTCA	0.475													7	414	---	---	---	---					
SALL4	57167	broad.mit.edu	37	20	50400982	50400983	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:50400982_50400983insC	ENST00000217086.4	-	4	3094_3095	c.2983_2984insG	c.(2983-2985)tccfs	p.S995fs	SALL4_ENST00000371539.3_Frame_Shift_Ins_p.S218fs|SALL4_ENST00000395997.3_Frame_Shift_Ins_p.S558fs	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	995					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGGGTAGGAACCCCCCCACTC	0.559													13	174	---	---	---	---					
C20orf85	128602	broad.mit.edu	37	20	56735726	56735727	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:56735726_56735727insC	ENST00000371168.3	+	4	323_324	c.262_263insC	c.(262-264)cccfs	p.P88fs		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	88										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GGTCTTTCCATCCCCCCCAGTC	0.579													10	73	---	---	---	---					
OSBPL2	9885	broad.mit.edu	37	20	60854257	60854258	+	Frame_Shift_Ins	INS	-	-	C	rs79735057		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr20:60854257_60854258insC	ENST00000313733.3	+	7	738_739	c.536_537insC	c.(535-537)cccfs	p.P179fs	OSBPL2_ENST00000439951.2_Frame_Shift_Ins_p.P87fs|OSBPL2_ENST00000358053.2_Frame_Shift_Ins_p.P167fs	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	179					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTCAGTCACCACCCCCCCATCA	0.465													20	167	---	---	---	---					
DOPEY2	9980	broad.mit.edu	37	21	37597905	37597906	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr21:37597905_37597906insC	ENST00000399151.3	+	12	1498_1499	c.1413_1414insC	c.(1411-1416)ccccccfs	p.PP471fs		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	471					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GCGTCAGCCCTCCCCCCACGGT	0.540													7	426	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr21:41514614_41514615insG	ENST00000400454.1	-	18	3753_3754	c.3276_3277insC	c.(3274-3279)ccaaaafs	p.PK1092fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1092	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.E1093K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406													12	326	---	---	---	---					
PDE9A	5152	broad.mit.edu	37	21	44171249	44171250	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr21:44171249_44171250insT	ENST00000291539.6	+	9	737_738	c.677_678insT	c.(676-678)attfs	p.I226fs	PDE9A_ENST00000398227.3_Frame_Shift_Ins_p.I66fs|PDE9A_ENST00000335512.4_Frame_Shift_Ins_p.I166fs|PDE9A_ENST00000539837.1_Frame_Shift_Ins_p.I98fs|PDE9A_ENST00000398229.3_Frame_Shift_Ins_p.I92fs|PDE9A_ENST00000398232.3_Frame_Shift_Ins_p.I159fs|PDE9A_ENST00000328862.6_Frame_Shift_Ins_p.I200fs|PDE9A_ENST00000398234.3_Frame_Shift_Ins_p.I125fs|PDE9A_ENST00000380328.2_Frame_Shift_Ins_p.I173fs|PDE9A_ENST00000335440.6_Frame_Shift_Ins_p.I124fs|PDE9A_ENST00000349112.3_Frame_Shift_Ins_p.I98fs|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398236.3_Frame_Shift_Ins_p.I140fs|PDE9A_ENST00000398224.3_Frame_Shift_Ins_p.I99fs|PDE9A_ENST00000398225.3_Frame_Shift_Ins_p.I185fs	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	226					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						TGTAAGTACAGTTTTTTGGATA	0.520													8	1166	---	---	---	---					
CECR1	51816	broad.mit.edu	37	22	17690423	17690424	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:17690423_17690424insC	ENST00000399839.1	-	2	414_415	c.144_145insG	c.(142-147)ggggctfs	p.A49fs	CECR1_ENST00000449907.2_Frame_Shift_Ins_p.A7fs|CECR1_ENST00000399837.2_Frame_Shift_Ins_p.A49fs|CECR1_ENST00000262607.3_Frame_Shift_Ins_p.A49fs			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	49	Dimerization.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				AGCACCAGCCGCCCCCCCAGCC	0.540													7	66	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	18020336	18020337	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:18020336_18020337insC	ENST00000262608.8	+	13	1668_1669	c.1668_1669insC	c.(1666-1671)ttccccfs	p.FP556fs	CECR2_ENST00000400585.2_Frame_Shift_Ins_p.FP414fs|CECR2_ENST00000400573.4_Frame_Shift_Ins_p.FP555fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	597					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		GAAAGTCGTTGCCCCCCACACG	0.639													7	162	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	18022285	18022286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:18022285_18022286insC	ENST00000262608.8	+	15	2390_2391	c.2390_2391insC	c.(2389-2391)gccfs	p.A797fs	CECR2_ENST00000400585.2_Frame_Shift_Ins_p.A655fs|CECR2_ENST00000400573.4_Frame_Shift_Ins_p.A796fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	838					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGACCACCTGTCCCCCCCAACC	0.609													14	589	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	18022443	18022444	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:18022443_18022444insG	ENST00000262608.8	+	15	2548_2549	c.2548_2549insG	c.(2548-2550)gggfs	p.G850fs	CECR2_ENST00000400585.2_Frame_Shift_Ins_p.G708fs|CECR2_ENST00000400573.4_Frame_Shift_Ins_p.G849fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	891					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCAGGCTCTTCGGGGGGTGCAG	0.634													16	457	---	---	---	---					
SERPIND1	3053	broad.mit.edu	37	22	21138419	21138420	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:21138419_21138420insG	ENST00000215727.5	+	3	1332_1333	c.1049_1050insG	c.(1048-1050)gggfs	p.G350fs	PI4KA_ENST00000466162.1_Intron|PI4KA_ENST00000255882.6_Intron|SERPIND1_ENST00000406799.1_Frame_Shift_Ins_p.G350fs|PI4KA_ENST00000572273.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	350					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CTGGAATACGTGGGGGGCATCA	0.540											OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	496	---	---	---	---					
C22orf43	51233	broad.mit.edu	37	22	23959767	23959769	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:23959767_23959769delCAT	ENST00000317749.5	-	7	809_811	c.512_514delATG	c.(511-516)gcc>g	p.DA171del		NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	171	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						CTTACCTGGGcatcatcatcatc	0.433													12	551	---	---	---	---					
GAS2L1	10634	broad.mit.edu	37	22	29708272	29708273	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:29708272_29708273insG	ENST00000406549.3	+	6	1301_1302	c.1151_1152insG	c.(1150-1152)aggfs	p.R384fs	GAS2L1_ENST00000407854.1_3'UTR|GAS2L1_ENST00000471961.1_3'UTR|GAS2L1_ENST00000407647.2_3'UTR|GAS2L1_ENST00000403764.1_3'UTR|GAS2L1_ENST00000360113.2_3'UTR			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	393					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						TGCCCTGGCATGGGGGGGCCAC	0.678													34	490	---	---	---	---					
THOC5	8563	broad.mit.edu	37	22	29925230	29925231	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:29925230_29925231insG	ENST00000490103.1	-	9	970		c.e9-2		CTA-256D12.11_ENST00000411969.1_RNA|THOC5_ENST00000397871.1_Splice_Site|THOC5_ENST00000397872.1_Splice_Site|THOC5_ENST00000397873.2_Splice_Site	NM_003678.4	NP_003669.4	Q13769	THOC5_HUMAN	THO complex 5						intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ACGTCTTATCTGGGGGGCAAGA	0.535													7	823	---	---	---	---					
TIMP3	7078	broad.mit.edu	37	22	33255323	33255324	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:33255323_33255324insC	ENST00000266085.6	+	5	896_897	c.595_596insC	c.(595-597)cccfs	p.P199fs	SYN3_ENST00000358763.2_Intron|SYN3_ENST00000332840.5_Intron	NM_000362.4	NP_000353.1	P35625	TIMP3_HUMAN	TIMP metallopeptidase inhibitor 3	199					negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(2)|large_intestine(3)|lung(1)|urinary_tract(1)	7						CCGAGGATGGGCCCCCCCGGAT	0.604													9	148	---	---	---	---					
POLR2F	5435	broad.mit.edu	37	22	38363690	38363691	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:38363690_38363691insG	ENST00000442738.2	+	5	477_478	c.352_353insG	c.(352-354)gggfs	p.G118fs	POLR2F_ENST00000470701.1_Frame_Shift_Ins_p.G113fs|POLR2F_ENST00000407936.1_Intron|POLR2F_ENST00000405557.1_Intron|POLR2F_ENST00000484894.1_Intron	NM_021974.3	NP_068809.1	P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F	118					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					CTATGAAGACTGGGGGGTGGAC	0.515													8	351	---	---	---	---					
DDX17	10521	broad.mit.edu	37	22	38895454	38895455	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:38895454_38895455insC	ENST00000396821.3	-	3	587_588	c.488_489insG	c.(487-489)ggafs	p.G163fs	DDX17_ENST00000381633.3_Frame_Shift_Ins_p.G84fs|DDX17_ENST00000432525.1_5'UTR	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	84	Helicase ATP-binding.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity	p.G163fs*20(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					GACAAACATCTCCCCCCCTCAC	0.381													13	147	---	---	---	---					
TNRC6B	23112	broad.mit.edu	37	22	40681766	40681767	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:40681766_40681767insC	ENST00000454349.2	+	12	3911_3912	c.3700_3701insC	c.(3700-3702)cccfs	p.P1234fs	TNRC6B_ENST00000402203.1_Frame_Shift_Ins_p.P430fs|TNRC6B_ENST00000301923.9_Frame_Shift_Ins_p.P430fs|TNRC6B_ENST00000335727.8_Frame_Shift_Ins_p.P1124fs|TNRC6B_ENST00000497559.1_3'UTR	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1234					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CCAGTTTATTTCCCCCCAGGTA	0.450													10	324	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41574678	41574679	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:41574678_41574679insC	ENST00000263253.7	+	31	8182_8183	c.6963_6964insC	c.(6961-6966)caccccfs	p.HP2321fs	RP1-85F18.5_ENST00000420537.1_RNA|RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2321					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CACAGTCCCAGCCCCCCCACTC	0.609			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				9	221	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610947	42610948	+	Frame_Shift_Ins	INS	-	-	G	rs138734341		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:42610947_42610948insG	ENST00000359486.3	-	1	500_501	c.364_365insC	c.(364-366)gggfs	p.G122fs	TCF20_ENST00000335626.4_Frame_Shift_Ins_p.G122fs	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	122				Q -> R (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GCTGCTCCCCTGGGGGGGTCCA	0.564													35	795	---	---	---	---					
TTLL1	25809	broad.mit.edu	37	22	43471583	43471584	+	Frame_Shift_Ins	INS	-	-	C	rs79088468		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:43471583_43471584insC	ENST00000331018.7	-	3	249_250	c.9_10insG	c.(7-12)ggaagtfs	p.S4fs	TTLL1_ENST00000445824.1_Frame_Shift_Ins_p.S4fs|TTLL1_ENST00000266254.7_Frame_Shift_Ins_p.S4fs			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	4	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		CATTTTACTTTCCCTGCCATAA	0.401													8	1478	---	---	---	---					
TBC1D22A	25771	broad.mit.edu	37	22	47188443	47188444	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chr22:47188443_47188444insC	ENST00000337137.4	+	2	255_256	c.89_90insC	c.(88-90)cccfs	p.P30fs	TBC1D22A_ENST00000472791.1_3'UTR|TBC1D22A_ENST00000406733.1_5'UTR|TBC1D22A_ENST00000407381.3_Frame_Shift_Ins_p.P30fs|TBC1D22A_ENST00000380995.1_5'UTR|TBC1D22A_ENST00000355704.3_Intron	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	30						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGTGCCCAGCACCCCCCCTTTG	0.569													25	497	---	---	---	---					
DHRSX	207063	broad.mit.edu	37	X	2343335	2343336	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:2343335_2343336insG	ENST00000334651.5	-	2	171_172	c.119_120insC	c.(118-120)ccgfs	p.P40fs		NM_145177.2	NP_660160.2	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	40							binding|oxidoreductase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)	16		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GGTCAGGTCGTGGGGGGAAAAC	0.455													9	341	---	---	---	---					
PRRG1	5638	broad.mit.edu	37	X	37312610	37312611	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:37312610_37312611insC	ENST00000542554.1	+	5	665_666	c.393_394insC	c.(391-396)ccccccfs	p.PP131fs	TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000491253.1_3'UTR|PRRG1_ENST00000378628.4_Frame_Shift_Ins_p.PP131fs|PRRG1_ENST00000543642.1_Frame_Shift_Ins_p.PP131fs|PRRG1_ENST00000449135.2_Frame_Shift_Ins_p.PP131fs	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	131	Poly-Pro.					extracellular region|integral to plasma membrane	calcium ion binding	p.P135fs*3(1)|p.P134fs*19(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						TTATCACCCCACCCCCCCCACC	0.485													24	240	---	---	---	---					
SLC9A7	84679	broad.mit.edu	37	X	46529118	46529118	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:46529118delA	ENST00000328306.4	-	5	742	c.717delT	c.(715-717)atfs	p.I239fs		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	239					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GCTGTCCCATAATCTTCATGA	0.383													8	208	---	---	---	---					
SSX9	280660	broad.mit.edu	37	X	48159107	48159108	+	Frame_Shift_Ins	INS	-	-	G	rs41305745	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:48159107_48159108insG	ENST00000376909.1	-	6	487_488	c.425_426insC	c.(424-426)cggfs	p.R142fs	SSX9_ENST00000407081.2_Frame_Shift_Ins_p.R142fs																breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						TTGGTTTTCCCGGGGGGCACAG	0.490													14	280	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48207024	48207025	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:48207024_48207025insC	ENST00000298396.2	-	7	533_534	c.481_482insG	c.(481-483)acafs	p.T161fs	SSX3_ENST00000376895.1_Frame_Shift_Ins_p.T73fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						CCAGGCATGTTCCCCCCTTTTG	0.480													17	1983	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48209462	48209463	+	Frame_Shift_Ins	INS	-	-	G	rs6651589	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:48209462_48209463insG	ENST00000298396.2	-	6	477_478	c.425_426insC	c.(424-426)cggfs	p.R142fs	SSX3_ENST00000376893.3_Frame_Shift_Ins_p.R142fs|SSX3_ENST00000376895.1_Frame_Shift_Ins_p.R54fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding	p.P142Q(2)		endometrium(3)|large_intestine(1)|lung(9)	13						TTGGTTTTCCCGGGGGGCACAG	0.495													9	436	---	---	---	---					
TFE3	7030	broad.mit.edu	37	X	48887951	48887952	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:48887951_48887952insC	ENST00000315869.7	-	10	1704_1705	c.1445_1446insG	c.(1444-1446)gccfs	p.A482fs	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	482					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						TCTGGGCAGGTCCCCCCCCTAC	0.649			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								30	286	---	---	---	---					
IL2RG	3561	broad.mit.edu	37	X	70327613	70327614	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:70327613_70327614insG	ENST00000374202.2	-	8	1173_1174	c.1082_1083insC	c.(1081-1083)ctgfs	p.L361fs	IL2RG_ENST00000456850.2_Frame_Shift_Ins_p.L171fs|IL2RG_ENST00000374188.3_Frame_Shift_Ins_p.L90fs	NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	361					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GGGTGTAACATGGGGGGGCCCA	0.584									Severe Combined Immunodeficiency, X-linked				7	64	---	---	---	---					
NOX1	27035	broad.mit.edu	37	X	100117691	100117692	+	Frame_Shift_Ins	INS	-	-	C	rs145552525	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:100117691_100117692insC	ENST00000372966.3	-	5	660_661	c.455_456insG	c.(454-456)gtcfs	p.V152fs	NOX1_ENST00000372960.4_Frame_Shift_Ins_p.V115fs|NOX1_ENST00000372964.1_Frame_Shift_Ins_p.V152fs|NOX1_ENST00000217885.5_Frame_Shift_Ins_p.V152fs	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	152	Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						TTAGCCAAGAACCCCCCTTTTT	0.500													9	1066	---	---	---	---					
BCORL1	63035	broad.mit.edu	37	X	129146962	129146963	+	Frame_Shift_Ins	INS	-	-	G	rs141901231	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:129146962_129146963insG	ENST00000540052.1	+	3	258_259	c.214_215insG	c.(214-216)gggfs	p.G72fs	BCORL1_ENST00000303743.5_Frame_Shift_Ins_p.G72fs|BCORL1_ENST00000359304.2_Frame_Shift_Ins_p.G72fs|BCORL1_ENST00000488135.1_3'UTR|BCORL1_ENST00000218147.7_Frame_Shift_Ins_p.G72fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	72					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CAGCAATGCCCGGGGGGCAGAC	0.569													13	416	---	---	---	---					
NSDHL	50814	broad.mit.edu	37	X	152037406	152037407	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	69e373e0-a10b-4728-af8d-a45ecdb39353	g.chrX:152037406_152037407insC	ENST00000370274.3	+	8	1062_1063	c.868_869insC	c.(868-870)cccfs	p.P290fs	NSDHL_ENST00000440023.1_Frame_Shift_Ins_p.P290fs	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	290					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	CAATTATGAGGCCCCCAAGTAC	0.559													7	1649	---	---	---	---					
STPG1	90529	broad.mit.edu	37	1	24700193	24700194	+	Splice_Site	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:24700193_24700194insG	ENST00000374409.1	-	6	823_824	c.571_splice	c.e6+1	p.R190_splice	STPG1_ENST00000003583.8_Splice_Site_p.R143_splice|STPG1_ENST00000337248.4_Splice_Site_p.R190_splice|STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000440416.1_Splice_Site_p.R143_splice	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		GCTGCTTACCTGGGGGAGGTCC	0.485													10	2473	---	---	---	---					
WASF2	10163	broad.mit.edu	37	1	27736340	27736340	+	Frame_Shift_Del	DEL	A	A	-	rs71584884		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:27736340delA	ENST00000430629.2	-	8	1400	c.1185delT	c.(1183-1185)ccfs	p.P400fs	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	400	Poly-Pro.				actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		gaggaggaggagggggaggag	0.642													15	157	---	---	---	---					
ADC	113451	broad.mit.edu	37	1	33583704	33583705	+	In_Frame_Ins	INS	-	-	TGG			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:33583704_33583705insTGG	ENST00000294517.6	+	11	1818_1819	c.1231_1232insTGG	c.(1231-1233)ccg>TGGccg	p.410_411insW	ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373443.3_In_Frame_Ins_p.410_411insW|ADC_ENST00000398167.1_In_Frame_Ins_p.430_431insW|ADC_ENST00000373441.1_In_Frame_Ins_p.430_431insW	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	410					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CTATGCCATGTCCCGGGTGGCC	0.579													7	119	---	---	---	---					
PTGFR	5737	broad.mit.edu	37	1	78958518	78958519	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:78958518_78958519insT	ENST00000370756.3	+	2	327_328	c.90_91insT	c.(88-93)gtttttfs	p.VF30fs	PTGFR_ENST00000370757.3_Frame_Shift_Ins_p.VF30fs|PTGFR_ENST00000370758.1_Frame_Shift_Ins_p.VF30fs	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	30					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GGCTTTCCGTATTTTTTTCAGT	0.450													17	1740	---	---	---	---					
PPM1J	333926	broad.mit.edu	37	1	113253630	113253631	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:113253630_113253631insT	ENST00000464951.1	-	8	1899_1900	c.492_splice	c.e8+1	p.S164_splice	RP11-426L16.10_ENST00000471038.2_Intron|RP11-426L16.10_ENST00000606505.1_Splice_Site_p.L52_splice|PPM1J_ENST00000309276.6_Splice_Site_p.S370_splice|PPM1J_ENST00000359994.4_Splice_Site_p.S164_splice			Q5JR12	PPM1J_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1J	370	PP2C-like.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	14	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGAGTTTACCTTTTTGCCCTC	0.559													8	1803	---	---	---	---					
SETDB1	9869	broad.mit.edu	37	1	150917623	150917624	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:150917623_150917624insG	ENST00000368962.2	+	9	1305_1306	c.1179_1180insG	c.(1177-1182)ggggggfs	p.GG393fs	SETDB1_ENST00000368969.4_Intron|SETDB1_ENST00000271640.5_Intron|SETDB1_ENST00000459773.1_Intron	NM_001243491.1	NP_001230420.1	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	0	Tudor 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGAGGTTGGTGGGGGGGGAAC	0.475													10	91	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152282888	152282893	+	In_Frame_Del	DEL	GTCCAC	GTCCAC	-	rs143101193		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:152282888_152282893delGTCCAC	ENST00000368799.1	-	3	4504_4509	c.4469_4474delGTGGAC	c.(4468-4476)cac>c	p.RGH1490del	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1490	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCCGGGTGTCCACGAATGGTGTC	0.583									Ichthyosis				14	631	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152283772	152283772	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:152283772delT	ENST00000368799.1	-	3	3625	c.3590delA	c.(3589-3591)ccfs	p.H1197fs	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1197	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATGTGGTGTGGCTGTGATG	0.562									Ichthyosis				33	502	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152283860	152283865	+	In_Frame_Del	DEL	GTGCAC	GTGCAC	-	rs58001094	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:152283860_152283865delGTGCAC	ENST00000368799.1	-	3	3532_3537	c.3497_3502delGTGCAC	c.(3496-3504)cac>c	p.RAH1166del	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1166	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCCGGGTGTGCACGAATGGTGTC	0.602									Ichthyosis				11	575	---	---	---	---					
BCAN	63827	broad.mit.edu	37	1	156628493	156628494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:156628493_156628494insC	ENST00000329117.4	+	13	2932_2933	c.2596_2597insC	c.(2596-2598)cccfs	p.P866fs	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	866	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCGTTGGGAGGCCCCCCAGATC	0.604													8	273	---	---	---	---					
RNASEL	6041	broad.mit.edu	37	1	182554908	182554909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:182554908_182554909insC	ENST00000367559.3	-	2	1286_1287	c.1033_1034insG	c.(1033-1035)agcfs	p.S345fs	RNASEL_ENST00000444138.1_Frame_Shift_Ins_p.S345fs|RNASEL_ENST00000539397.1_Frame_Shift_Ins_p.S345fs	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	345					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						CTTCAGGGCTGCCCCCCAGTGT	0.455													8	255	---	---	---	---					
ATP2B4	493	broad.mit.edu	37	1	203668728	203668729	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:203668728_203668729insG	ENST00000357681.5	+	4	1655_1656	c.532_533insG	c.(532-534)gggfs	p.G178fs	ATP2B4_ENST00000367218.3_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000391954.2_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000367219.3_Frame_Shift_Ins_p.G178fs|ATP2B4_ENST00000341360.2_Frame_Shift_Ins_p.G178fs	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	178					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAGCAATTCCGGGGGCTGCAG	0.510													9	908	---	---	---	---					
SUSD4	55061	broad.mit.edu	37	1	223395558	223395559	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr1:223395558_223395559insC	ENST00000343846.3	-	8	2081_2082	c.1448_1449insG	c.(1447-1449)accfs	p.T483fs	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_Frame_Shift_Ins_p.T323fs|SUSD4_ENST00000366878.4_Frame_Shift_Ins_p.T483fs			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	483						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CCATTAGAGGAATCTCTGTAAA	0.406													64	599	---	---	---	---					
SLC30A3	7781	broad.mit.edu	37	2	27478187	27478188	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:27478187_27478188insG	ENST00000233535.4	-	8	1511_1512	c.1159_1160insC	c.(1159-1161)agcfs	p.S387fs	SLC30A3_ENST00000447008.2_Frame_Shift_Ins_p.S382fs	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	387					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTCAGGCTTGGGGGGGTTCC	0.658													20	287	---	---	---	---					
XDH	7498	broad.mit.edu	37	2	31598344	31598345	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:31598344_31598345delCA	ENST00000379416.3	-	15	1551_1552	c.1503_1504delTG	c.(1501-1506)ccgtfs	p.PG501fs		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	501					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ACCATGCCACCAGGGGCATCGG	0.604													17	110	---	---	---	---					
B3GNT2	10678	broad.mit.edu	37	2	62449597	62449598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:62449597_62449598insG	ENST00000301998.4	+	2	494_495	c.242_243insG	c.(241-243)aggfs	p.R81fs	B3GNT2_ENST00000405767.1_Frame_Shift_Ins_p.R81fs	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	81						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	p.T81T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			ACCAACCAGACGGGGGAGGCGG	0.554													7	2316	---	---	---	---					
PLEK	5341	broad.mit.edu	37	2	68622886	68622887	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:68622886_68622887insC	ENST00000234313.7	+	9	1170_1171	c.991_992insC	c.(991-993)cccfs	p.P331fs		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	331	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GCAAGCAGCCACCCCCAAGGAG	0.540													8	740	---	---	---	---					
NAT8	9027	broad.mit.edu	37	2	73868608	73868609	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:73868608_73868609insC	ENST00000272425.3	-	2	296_297	c.147_148insG	c.(145-150)ggccctfs	p.GP49fs		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	49					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						AGGGCGAGGGGCCCCCCAAGTA	0.614													8	593	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	6	---	---	---	---					
ATG16L1	55054	broad.mit.edu	37	2	234171866	234171866	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr2:234171866delC	ENST00000392017.4	+	3	557	c.300delC	c.(298-300)cafs	p.H100fs	ATG16L1_ENST00000373525.5_Intron|ATG16L1_ENST00000392020.4_Frame_Shift_Del_p.H100fs|ATG16L1_ENST00000347464.5_Intron|ATG16L1_ENST00000392018.1_Frame_Shift_Del_p.H100fs	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	100					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		CTGAATTACACAAGAAACGTG	0.502													10	44	---	---	---	---					
VHL	7428	broad.mit.edu	37	3	10188268	10188269	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:10188268_10188269insC	ENST00000256474.2	+	2	1251_1252	c.411_412insC	c.(409-414)gtcatcfs	p.I138fs	VHL_ENST00000477538.1_3'UTR|VHL_ENST00000345392.2_Intron	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	138	Involved in binding to CCT complex.				anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.P138fs*1(2)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		AATTATTTGTGCCATCTCTCAA	0.421		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				78	139	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14538073	14538073	+	RNA	DEL	A	A	-	rs11333211		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:14538073delA	ENST00000273083.3	-	0	2744							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						GGATGCCTGCAAGGAACACGG	0.607													8	146	---	---	---	---					
CADPS	8618	broad.mit.edu	37	3	62459994	62459995	+	Splice_Site	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:62459994_62459995insA	ENST00000383710.4	-	24	3679_3680	c.3329_splice	c.e24-1	p.Q1111_splice	CADPS_ENST00000283269.9_Splice_Site_p.Q1072_splice|CADPS_ENST00000357948.3_Splice_Site_p.Q1032_splice	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1111	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GCAATCCTGGTTCTATTAAAAC	0.396													24	144	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87018182	87018183	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:87018182_87018183insC	ENST00000398399.2	-	3	857_858	c.494_495insG	c.(493-495)ggtfs	p.G165fs	VGLL3_ENST00000383698.3_Frame_Shift_Ins_p.G165fs	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGGATGAACTCCCCCCAAACA	0.579													9	325	---	---	---	---					
IFT122	55764	broad.mit.edu	37	3	129183576	129183577	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:129183576_129183577insG	ENST00000296266.3	+	8	860_861	c.668_669insG	c.(667-669)cggfs	p.R223fs	IFT122_ENST00000507564.1_Frame_Shift_Ins_p.R223fs|IFT122_ENST00000440957.2_Frame_Shift_Ins_p.R22fs|IFT122_ENST00000431818.2_Frame_Shift_Ins_p.R22fs|IFT122_ENST00000348417.2_Frame_Shift_Ins_p.R172fs|IFT122_ENST00000347300.2_Frame_Shift_Ins_p.R172fs|IFT122_ENST00000504021.1_Frame_Shift_Ins_p.R125fs|IFT122_ENST00000349441.2_Frame_Shift_Ins_p.R120fs	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	172					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium		p.P223P(1)		breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						ATCGAGCGGCCGGGGGGCTCCC	0.505													8	324	---	---	---	---					
PLXND1	23129	broad.mit.edu	37	3	129324871	129324872	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:129324871_129324872insC	ENST00000393239.1	-	1	789_790	c.611_612insG	c.(610-612)gagfs	p.E204fs	PLXND1_ENST00000324093.4_Frame_Shift_Ins_p.E204fs			Q9Y4D7	PLXD1_HUMAN	plexin D1	204	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GCAGGCGGCTgccccccgcgcc	0.708													2	4	---	---	---	---					
COL6A6	131873	broad.mit.edu	37	3	130281934	130281935	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:130281934_130281935insT	ENST00000358511.6	+	2	118_119	c.87_88insT	c.(85-90)gtttttfs	p.VF29fs	COL6A6_ENST00000453409.2_Frame_Shift_Ins_p.VF29fs	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	29	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CAGATGTTGTGTTTTTGGTGGA	0.431													8	723	---	---	---	---					
STAG1	10274	broad.mit.edu	37	3	136141378	136141379	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:136141378_136141379delAC	ENST00000383202.2	-	19	2166_2167	c.1910_1911delGT	c.(1909-1911)afs	p.S637fs	STAG1_ENST00000434713.2_Frame_Shift_Del_p.S411fs|STAG1_ENST00000536929.1_Frame_Shift_Del_p.S221fs|STAG1_ENST00000236698.5_Frame_Shift_Del_p.S637fs	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	637					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TATAGGTTTTACTGCAGGCTTC	0.371													33	108	---	---	---	---					
KPNA4	3840	broad.mit.edu	37	3	160245789	160245789	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:160245789delG	ENST00000334256.4	-	8	813	c.508delC	c.(508-510)atfs	p.H170fs		NM_002268.4	NP_002259.1	O00629	IMA4_HUMAN	karyopherin alpha 4 (importin alpha 3)	170	NLS binding site (major) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)	22			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ACATTCTGATGGGGTGAATGG	0.348													48	51	---	---	---	---					
BCHE	590	broad.mit.edu	37	3	165547909	165547915	+	Frame_Shift_Del	DEL	CTTCATT	CTTCATT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:165547909_165547915delCTTCATT	ENST00000264381.3	-	2	1073_1079	c.907_913delAATGAAG	c.(907-915)cafs	p.NEA303fs	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	303					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ACAACAAATGCTTCATTCAGAAGAATT	0.401													33	123	---	---	---	---					
LPP	4026	broad.mit.edu	37	3	188478066	188478066	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr3:188478066delA	ENST00000312675.4	+	8	1652	c.1406delA	c.(1405-1407)tcfs	p.Y469fs	LPP_ENST00000543006.1_Frame_Shift_Del_p.Y469fs	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	469	LIM zinc-binding 1.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GAGCCCTGCTACATTGTAAGT	0.453			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								11	250	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2674078	2674079	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:2674078_2674079insC	ENST00000324666.5	+	11	1788_1789	c.1437_1438insC	c.(1435-1440)acccccfs	p.TP479fs	FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.TP479fs|FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.TP479fs|FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.TP479fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.TP501fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	479										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGTATGCAACGCCCCCCTTCAC	0.510													7	258	---	---	---	---					
CORIN	10699	broad.mit.edu	37	4	47676518	47676519	+	Splice_Site	INS	-	-	TT			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:47676518_47676519insTT	ENST00000273857.4	-	10	1249		c.e10-1		CORIN_ENST00000504584.1_Splice_Site|CORIN_ENST00000502252.1_Splice_Site|CORIN_ENST00000508498.1_Splice_Site|CORIN_ENST00000505909.1_Splice_Site	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase						peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GAAGTCTGAACTACAGAGGGAG	0.441													56	421	---	---	---	---					
C4orf32	132720	broad.mit.edu	37	4	113107915	113107916	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:113107915_113107916insT	ENST00000309733.4	+	2	404_405	c.220_221insT	c.(220-222)tttfs	p.F74fs		NM_152400.2	NP_689613.1	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	74						integral to membrane							Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		AATGGGAACACTTTTTGGTGAA	0.366													8	760	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134071648	134071649	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:134071648_134071649insC	ENST00000264360.4	+	1	1179_1180	c.353_354insC	c.(352-354)accfs	p.T118fs		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	118	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S121fs*13(1)		NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTAATGACAACCCCCCCTCTT	0.604													7	213	---	---	---	---					
SNX25	83891	broad.mit.edu	37	4	186188239	186188240	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr4:186188239_186188240insC	ENST00000504273.1	+	5	823_824	c.529_530insC	c.(529-531)cccfs	p.P177fs	SNX25_ENST00000264694.8_Frame_Shift_Ins_p.P177fs			Q9H3E2	SNX25_HUMAN	sorting nexin 25	177					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CTACACCTATGCCCCCTCTTAC	0.441													10	381	---	---	---	---					
ZNF366	167465	broad.mit.edu	37	5	71739905	71739906	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:71739905_71739906insG	ENST00000318442.5	-	5	2402_2403	c.1912_1913insC	c.(1912-1914)gagfs	p.E638fs		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CTGCTGGCTCTGGGGGGCCAGG	0.653													7	607	---	---	---	---					
CEP120	153241	broad.mit.edu	37	5	122713212	122713213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:122713212_122713213insT	ENST00000306467.5	-	16	2517_2518	c.2213_2214insA	c.(2212-2214)agafs	p.R738fs	CEP120_ENST00000306481.6_Frame_Shift_Ins_p.R712fs|CEP120_ENST00000328236.5_Frame_Shift_Ins_p.R738fs			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	738						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						ATTGCAGTTCCTTTTTTTCTCT	0.391													9	290	---	---	---	---					
HSPA4	3308	broad.mit.edu	37	5	132432907	132432907	+	Frame_Shift_Del	DEL	G	G	-	rs143003242	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:132432907delG	ENST00000304858.2	+	15	2147	c.1858delG	c.(1858-1860)cafs	p.A620fs		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	620					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCTAAGAACGCAGTGGAGGA	0.373													14	580	---	---	---	---					
WWC1	23286	broad.mit.edu	37	5	167850576	167850577	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr5:167850576_167850577insC	ENST00000265293.4	+	11	1815_1816	c.1313_1314insC	c.(1312-1314)accfs	p.T438fs	WWC1_ENST00000521089.1_Frame_Shift_Ins_p.T438fs	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	438					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		TCAGGCAGCAGCCCCGGATCCC	0.614													7	2448	---	---	---	---					
GPR115	221393	broad.mit.edu	37	6	47680115	47680115	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:47680115delT	ENST00000283303.2	+	5	581	c.323delT	c.(322-324)ctfs	p.L108fs	GPR115_ENST00000327753.3_Frame_Shift_Del_p.L108fs|GPR115_ENST00000371220.1_Frame_Shift_Del_p.L165fs	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	108					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GCATCTCGCCTTTCTGTAGCA	0.408													293	192	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55113573	55113574	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:55113573_55113574insT	ENST00000370862.3	+	2	696_697	c.360_361insT	c.(358-363)tgttttfs	p.CF120fs		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	120					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGAGACCTGGTTTTTTGGACA	0.431													11	646	---	---	---	---					
DST	667	broad.mit.edu	37	6	56471391	56471392	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:56471391_56471392delAG	ENST00000370754.5	-	39	7934_7935	c.7935_7936delCT	c.(7933-7938)agtafs	p.SL2645fs	DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Frame_Shift_Del_p.SL2467fs|DST_ENST00000312431.6_Frame_Shift_Del_p.SL2467fs|DST_ENST00000370788.2_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000361203.3_Frame_Shift_Del_p.SL2467fs|DST_ENST00000446842.2_Frame_Shift_Del_p.SL2141fs			Q03001	DYST_HUMAN	dystonin	2467					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCACACTTAAGCTACCAACTG	0.386													10	112	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75827102	75827103	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:75827102_75827103insT	ENST00000322507.8	-	47	7823_7824	c.7514_7515insA	c.(7513-7515)atcfs	p.I2505fs	COL12A1_ENST00000345356.6_Frame_Shift_Ins_p.I1341fs|COL12A1_ENST00000416123.2_Frame_Shift_Ins_p.I2505fs|COL12A1_ENST00000483888.2_Frame_Shift_Ins_p.I2505fs	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2505	Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACTTACTTGAAGTGGCAGTTTC	0.381													15	155	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75866087	75866088	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr6:75866087_75866088insG	ENST00000322507.8	-	15	3444_3445	c.3135_3136insC	c.(3133-3138)cccagtfs	p.S1046fs	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Frame_Shift_Ins_p.S1046fs|COL12A1_ENST00000483888.2_Frame_Shift_Ins_p.S1046fs	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1046	Fibronectin type-III 7.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.T1046fs*7(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GAAGTGACTGTGGGGGGCACCT	0.490													10	245	---	---	---	---					
GPNMB	10457	broad.mit.edu	37	7	23306134	23306135	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:23306134_23306135insT	ENST00000381990.2	+	7	1214_1215	c.1053_1054insT	c.(1051-1056)ccgaccfs	p.T352fs	GPNMB_ENST00000453162.2_Frame_Shift_Ins_p.T294fs|GPNMB_ENST00000539136.1_Splice_Site|GPNMB_ENST00000258733.4_Splice_Site	NM_001005340.1|NM_002510.2	NP_001005340.1|NP_002501.1	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	352					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			CAAACACCCCAGGACCTGCTGG	0.386													7	108	---	---	---	---					
HOXA9	3205	broad.mit.edu	37	7	27203289	27203289	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:27203289delT	ENST00000343483.6	-	2	824	c.752delA	c.(751-753)agfs	p.K251fs	RP1-170O19.20_ENST00000465941.1_5'UTR|RP1-170O19.20_ENST00000470747.4_Frame_Shift_Del_p.K91fs|HOXA9_ENST00000396345.1_3'UTR|HOXA9_ENST00000497089.1_5'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	251							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						GAACCAGATCTTGACCTGCCT	0.483			T	"""NUP98, MSI2"""	AML*								7	495	---	---	---	---					
NPSR1	387129	broad.mit.edu	37	7	34888227	34888228	+	Frame_Shift_Ins	INS	-	-	C	rs139125527	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:34888227_34888228insC	ENST00000360581.1	+	8	1105_1106	c.977_978insC	c.(976-978)accfs	p.T326fs	NPSR1_ENST00000381539.3_Frame_Shift_Ins_p.T326fs|NPSR1_ENST00000359791.1_Frame_Shift_Ins_p.T326fs|NPSR1_ENST00000531252.1_Frame_Shift_Ins_p.T315fs|NPSR1_ENST00000381542.1_Frame_Shift_Ins_p.T260fs	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	326						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	AGTGCCATCAACCCCCTCATCT	0.500													7	635	---	---	---	---					
EPHB4	2050	broad.mit.edu	37	7	100404119	100404120	+	Frame_Shift_Ins	INS	-	-	CTGA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:100404119_100404120insCTGA	ENST00000358173.3	-	14	2874_2875	c.2406_2407insTCAG	c.(2404-2409)gacctgfs	p.L803fs	EPHB4_ENST00000360620.3_Frame_Shift_Ins_p.L803fs	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	803	Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TAACTCCAGGCATCACTGGCGG	0.554													33	994	---	---	---	---					
DOCK4	9732	broad.mit.edu	37	7	111418424	111418425	+	Splice_Site	INS	-	-	GA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr7:111418424_111418425insGA	ENST00000428084.1	-	36	3858_3859	c.3585_splice	c.e36-1	p.L1196_splice	DOCK4_ENST00000494651.2_Splice_Site_p.L70_splice|DOCK4_ENST00000437633.1_Splice_Site_p.L1187_splice			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1187	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CTTATAGAAGTTCTGTAAAAAA	0.381													14	220	---	---	---	---					
SORBS3	10174	broad.mit.edu	37	8	22414410	22414411	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr8:22414410_22414411insC	ENST00000240123.7	+	4	786_787	c.403_404insC	c.(403-405)cccfs	p.P135fs	SORBS3_ENST00000523402.1_Frame_Shift_Ins_p.P135fs	NM_005775.4	NP_005766.3	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3	135	SoHo.				muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)	18		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CATGCCCATTGCCCCCCGATCC	0.634													12	421	---	---	---	---					
VPS13B	157680	broad.mit.edu	37	8	100887780	100887781	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr8:100887780_100887781insC	ENST00000358544.2	+	62	12066_12067	c.11955_11956insC	c.(11953-11958)ccccccfs	p.PP3985fs	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Frame_Shift_Ins_p.PP3960fs	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3985					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGCAGAACCTCCCCCCTCCAC	0.465													11	294	---	---	---	---					
TEK	7010	broad.mit.edu	37	9	27172694	27172695	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr9:27172694_27172695delAC	ENST00000380036.4	+	5	1151_1152	c.709_710delAC	c.(709-711)tfs	p.T237fs	TEK_ENST00000406359.4_Frame_Shift_Del_p.T237fs|TEK_ENST00000519097.1_Frame_Shift_Del_p.T133fs	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	237	EGF-like 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CCATGAAGATACTGGAGAATGC	0.436													22	178	---	---	---	---					
TSTD2	158427	broad.mit.edu	37	9	100389762	100389763	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr9:100389762_100389763insG	ENST00000341170.4	-	2	464_465	c.82_83insC	c.(82-84)gagfs	p.E28fs	TSTD2_ENST00000375172.2_5'UTR|TSTD2_ENST00000354801.2_5'UTR	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	28										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						AATAAGACTCATATCTTTTAAA	0.376													16	331	---	---	---	---					
CDK5RAP2	55755	broad.mit.edu	37	9	123169393	123169394	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr9:123169393_123169394delCT	ENST00000349780.4	-	32	5038_5039	c.4859_4860delAG	c.(4858-4860)afs	p.K1620fs	CDK5RAP2_ENST00000360822.3_Frame_Shift_Del_p.K1588fs|CDK5RAP2_ENST00000360190.4_Intron|CDK5RAP2_ENST00000359309.3_Frame_Shift_Del_p.K1579fs	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1620					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CCAGCTGTTCCTTGAGCCTGCT	0.594													37	682	---	---	---	---					
PRKCQ	5588	broad.mit.edu	37	10	6506351	6506352	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:6506351_6506352insA	ENST00000263125.5	-	13	1467_1468	c.1368_1369insT	c.(1366-1371)tttgatfs	p.D457fs	PRKCQ_ENST00000539722.1_Frame_Shift_Ins_p.D332fs|PRKCQ_ENST00000397176.2_Frame_Shift_Ins_p.D457fs	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	457	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TACTCCATCACAAAAAAGAGGT	0.401													13	1167	---	---	---	---					
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>AGGAGGggg	p.428_429insRR	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insRR	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													32	35	---	---	---	---					
ZFYVE27	118813	broad.mit.edu	37	10	99504492	99504499	+	Frame_Shift_Del	DEL	GGTACTCA	GGTACTCA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr10:99504492_99504499delGGTACTCA	ENST00000393677.4	+	4	479_486	c.275_282delGGTACTCA	c.(274-282)tfs	p.WYS92fs	ZFYVE27_ENST00000359980.3_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000356257.4_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000370613.3_Intron|ZFYVE27_ENST00000453958.2_Frame_Shift_Del_p.WYS92fs|ZFYVE27_ENST00000337540.7_Frame_Shift_Del_p.WYS60fs|ZFYVE27_ENST00000370610.3_5'UTR|ZFYVE27_ENST00000357540.4_Intron	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	92					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		GCAGGTGCATGGTACTCAGTAGGTGCCC	0.577													8	134	---	---	---	---					
CARS	833	broad.mit.edu	37	11	3023250	3023251	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:3023250_3023251insG	ENST00000397114.3	-	22	2407_2408	c.2031_2032insC	c.(2029-2034)ccgtgafs	p.*678fs	CARS_ENST00000380525.4_Frame_Shift_Ins_p.*771fs|CARS_ENST00000278224.9_Frame_Shift_Ins_p.*688fs|CARS_ENST00000470221.2_5'UTR|CARS_ENST00000397111.5_Frame_Shift_Ins_p.*688fs|CARS_ENST00000401769.3_Frame_Shift_Ins_p.*701fs			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	688					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	AACATCTCACTGGGGGGAATCT	0.495			T	ALK	ALCL								9	1015	---	---	---	---					
FAM160A2	84067	broad.mit.edu	37	11	6244063	6244064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:6244063_6244064insC	ENST00000265978.4	-	5	1358_1359	c.1000_1001insG	c.(1000-1002)catfs	p.H334fs	FAM160A2_ENST00000524416.1_Frame_Shift_Ins_p.H334fs|FAM160A2_ENST00000449352.2_Frame_Shift_Ins_p.H334fs	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	334					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGACCCATGACAGGCACCAGG	0.545													17	752	---	---	---	---					
NAV2	89797	broad.mit.edu	37	11	20067148	20067149	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:20067148_20067149insA	ENST00000396085.1	+	14	4195_4196	c.3834_3835insA	c.(3832-3837)tcgtccfs	p.S1279fs	NAV2_ENST00000396087.3_Frame_Shift_Ins_p.S1302fs|NAV2_ENST00000360655.4_Frame_Shift_Ins_p.S1215fs|NAV2_ENST00000533917.1_Frame_Shift_Ins_p.S365fs|NAV2_ENST00000540292.1_Frame_Shift_Ins_p.S1233fs|NAV2_ENST00000349880.4_Frame_Shift_Ins_p.S1279fs|NAV2_ENST00000527559.2_Frame_Shift_Ins_p.S1231fs|NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000311043.8_Frame_Shift_Ins_p.S365fs	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1302						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AGCCTGTGTCCAGTCCGGCTCA	0.545													11	176	---	---	---	---					
CCDC73	493860	broad.mit.edu	37	11	32637520	32637520	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:32637520delT	ENST00000335185.5	-	15	1384	c.1341delA	c.(1339-1341)aafs	p.K447fs	CCDC73_ENST00000534415.1_5'UTR	NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	447										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ATGAGCCTTCTTTTTTTTCTT	0.249													2	4	---	---	---	---					
ACCSL	390110	broad.mit.edu	37	11	44080010	44080011	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:44080010_44080011insT	ENST00000378832.1	+	12	1526		c.e12+1			NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like								1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						CTTGAAAAAGGTGTGTTCTGGG	0.535													17	283	---	---	---	---					
OR5M1	390168	broad.mit.edu	37	11	56380547	56380550	+	Frame_Shift_Del	DEL	CAGA	CAGA	-	rs71931749		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:56380547_56380550delCAGA	ENST00000526538.1	-	1	428_431	c.429_432delTCTG	c.(427-432)tgfs	p.CL143fs		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GGATAGTGACCAGACAGACACAGA	0.436													25	290	---	---	---	---					
PHLDB1	23187	broad.mit.edu	37	11	118495753	118495754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:118495753_118495754insC	ENST00000361417.2	+	6	870_871	c.459_460insC	c.(457-462)ggccccfs	p.GP153fs	PHLDB1_ENST00000356063.5_Frame_Shift_Ins_p.GP153fs	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	153										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GAGCCCCTGGGCCCCCCTACAG	0.609													8	554	---	---	---	---					
GLB1L3	112937	broad.mit.edu	37	11	134181004	134181005	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr11:134181004_134181005insC	ENST00000431683.2	+	13	1227_1228	c.1227_1228insC	c.(1225-1230)taccccfs	p.YP409fs		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	409					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		AGGCTGTGTATCCCCCCGTGAG	0.604													14	1559	---	---	---	---					
FOXM1	2305	broad.mit.edu	37	12	2968087	2968088	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:2968087_2968088insG	ENST00000342628.2	-	10	2235_2236	c.2122_2123insC	c.(2122-2124)tgafs	p.*708fs	FOXM1_ENST00000359843.3_Frame_Shift_Ins_p.*670fs|ITFG2_ENST00000545509.1_Intron|FOXM1_ENST00000361953.3_Frame_Shift_Ins_p.*655fs	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	670					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CGGTGATTCAAGGGGGGGAGCA	0.579													9	228	---	---	---	---					
KRT85	3891	broad.mit.edu	37	12	52760911	52760912	+	Frame_Shift_Ins	INS	-	-	G	rs143575567		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:52760911_52760912insG	ENST00000257901.3	-	1	353_354	c.278_279insC	c.(277-279)ctgfs	p.L93fs		NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	93	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TAGTGATGCATGGGGGGCTGGG	0.673													9	717	---	---	---	---					
SP1	6667	broad.mit.edu	37	12	53776725	53776727	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:53776725_53776727delACC	ENST00000426431.2	+	3	1033_1035	c.973_975delACC	c.(973-975)del	p.T326del	SP1_ENST00000327443.4_In_Frame_Del_p.T333del	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	333	Ser/Thr-rich.|Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		AACTACTACTACCACCAGCAACA	0.502													9	174	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89462551	89462552	+	RNA	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:89462551_89462552insA	ENST00000549278.1	-	0	282																											agacagaatataaaaaagggag	0.406													2	4	---	---	---	---					
SDSL	113675	broad.mit.edu	37	12	113872000	113872001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:113872000_113872001insC	ENST00000403593.4	+	5	678_679	c.416_417insC	c.(415-417)gccfs	p.A139fs	SDSL_ENST00000345635.4_Frame_Shift_Ins_p.A139fs			Q96GA7	SDSL_HUMAN	serine dehydratase-like	139					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	TGGGAGAATGTCCCCCCGTTTG	0.614													7	924	---	---	---	---					
RNF34	80196	broad.mit.edu	37	12	121855615	121855616	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:121855615_121855616insT	ENST00000361234.5	+	3	706_707	c.534_535insT	c.(532-537)tcttttfs	p.SF178fs	RNF34_ENST00000392464.2_Frame_Shift_Ins_p.SF178fs|RNF34_ENST00000392465.3_Frame_Shift_Ins_p.SF179fs|RNF34_ENST00000555076.1_Intron	NM_025126.3	NP_079402.2	Q969K3	RNF34_HUMAN	ring finger protein 34, E3 ubiquitin protein ligase	178					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding			breast(1)|large_intestine(1)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		TTACACGTTCGTTTTTTTCAAA	0.470													8	392	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124846815	124846816	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr12:124846815_124846816insG	ENST00000356219.3	-	23	3108_3109	c.2953_2954insC	c.(2953-2955)ggafs	p.G985fs	NCOR2_ENST00000404121.2_Frame_Shift_Ins_p.G539fs|NCOR2_ENST00000397355.1_Frame_Shift_Ins_p.G969fs|NCOR2_ENST00000405201.1_Frame_Shift_Ins_p.G986fs|NCOR2_ENST00000404621.1_Frame_Shift_Ins_p.G968fs|NCOR2_ENST00000429285.2_Frame_Shift_Ins_p.G968fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	986					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGCGTCCTCCCGGGGGGGCTCA	0.653													2	4	---	---	---	---					
CENPJ	55835	broad.mit.edu	37	13	25480659	25480660	+	In_Frame_Ins	INS	-	-	AAA			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr13:25480659_25480660insAAA	ENST00000381884.4	-	7	1701_1702	c.1516_1517insTTT	c.(1516-1518)tcc>TTTtcc	p.505_506insF	CENPJ_ENST00000545981.1_In_Frame_Ins_p.505_506insF	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	505					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AGGTTTTGGACACTCAGTTACA	0.436													7	176	---	---	---	---					
FLT3	2322	broad.mit.edu	37	13	28608071	28608072	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr13:28608071_28608072insCC	ENST00000380982.4	-	15	1975_1976	c.1894_1895insGG	c.(1894-1896)tagfs	p.*632fs	FLT3_ENST00000537084.1_Frame_Shift_Ins_p.*632fs|FLT3_ENST00000241453.7_Frame_Shift_Ins_p.*632fs			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	632	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGTTTTGCTAATTCCATAAGCT	0.426			"""Mis, O"""		"""AML, ALL"""								115	1248	---	---	---	---					
CPB2	1361	broad.mit.edu	37	13	46658415	46658416	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr13:46658415_46658416insA	ENST00000181383.4	-	3	229_230	c.213_214insT	c.(211-216)tttaaafs	p.K72fs	CPB2-AS1_ENST00000606991.1_RNA|CPB2-AS1_ENST00000606351.1_RNA|CPB2-AS1_ENST00000415033.2_RNA|CPB2-AS1_ENST00000606243.1_RNA|CPB2_ENST00000439329.3_Frame_Shift_Ins_p.K72fs	NM_001872.3	NP_001863.3	Q96IY4	CBPB2_HUMAN	carboxypeptidase B2 (plasma)	72					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(3)|liver(1)|lung(9)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		GATGCATTTACAAAAAAATGGA	0.361													7	265	---	---	---	---					
DHRS4L1	728635	broad.mit.edu	37	14	24518025	24518025	+	RNA	DEL	G	G	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:24518025delG	ENST00000558293.1	+	0	668					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		AGGATGGTGAGGAAGGGGAGC	0.537													7	617	---	---	---	---					
NYNRIN	57523	broad.mit.edu	37	14	24885703	24885708	+	In_Frame_Del	DEL	GCAGGA	GCAGGA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:24885703_24885708delGCAGGA	ENST00000382554.3	+	9	5066_5071	c.4748_4753delGCAGGA	c.(4747-4755)tgc>t	p.CRS1583del		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1583					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						AAAGATTACTGCAGGAGCTGCTTGTT	0.583													13	53	---	---	---	---					
PAX9	5083	broad.mit.edu	37	14	37145441	37145442	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:37145441_37145442insC	ENST00000361487.6	+	4	1035_1036	c.810_811insC	c.(808-813)tccatcfs	p.I271fs	PAX9_ENST00000402703.2_Frame_Shift_Ins_p.I271fs|PAX9_ENST00000554201.1_Frame_Shift_Ins_p.P80fs|PAX9_ENST00000557107.1_3'UTR			P55771	PAX9_HUMAN	paired box 9	271					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		GTTTTGTGTCAGCATCCAGCAT	0.485													17	428	---	---	---	---					
NPC2	10577	broad.mit.edu	37	14	74947387	74947388	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:74947387_74947388insC	ENST00000557510.1	-	4	530_531	c.458_459insG	c.(457-459)ggafs	p.G153fs	NPC2_ENST00000555619.1_Intron|NPC2_ENST00000541064.1_Intron|NPC2_ENST00000434013.2_Intron|NPC2_ENST00000238633.2_Intron			P61916	NPC2_HUMAN	Niemann-Pick disease, type C2	0					cholesterol efflux|cholesterol homeostasis|glycolipid transport|intracellular cholesterol transport|phospholipid transport|regulation of isoprenoid metabolic process|response to virus	extracellular region|lysosome	cholesterol binding|enzyme binding			breast(1)|endometrium(2)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.00149)		ATGCCCTCTCACCCCCAGATAG	0.450													7	855	---	---	---	---					
PACS2	23241	broad.mit.edu	37	14	105818753	105818754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr14:105818753_105818754insC	ENST00000447393.1	+	3	421_422	c.246_247insC	c.(244-249)ctccccfs	p.LP82fs	PACS2_ENST00000547217.1_Intron|PACS2_ENST00000458164.2_Frame_Shift_Ins_p.LP82fs|PACS2_ENST00000325438.8_Frame_Shift_Ins_p.LP82fs|PACS2_ENST00000430725.2_Frame_Shift_Ins_p.LP15fs	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	82					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		AGATTGTGCTGCCCCCCAGTGG	0.550											OREG0022968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	666	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25449554	25449564	+	RNA	DEL	AAATCATTCTC	AAATCATTCTC	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:25449554_25449564delAAATCATTCTC	ENST00000424208.1	+	0	2339				SNHG14_ENST00000424333.1_RNA|SNORD115-19_ENST00000363098.1_RNA	NR_003305.1																						GATGACTTAAAAATCATTCTCAAAAGGATTA	0.512													24	173	---	---	---	---					
PRTG	283659	broad.mit.edu	37	15	55912218	55912219	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:55912218_55912219insG	ENST00000389286.4	-	20	3491_3492	c.3444_3445insC	c.(3442-3447)ccacctfs	p.P1149fs		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1149					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AATCAGAGGTTGGGGGGTGTGG	0.490													8	272	---	---	---	---					
POLG	5428	broad.mit.edu	37	15	89871987	89871988	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:89871987_89871988insC	ENST00000268124.5	-	5	1431_1432	c.1098_1099insG	c.(1096-1101)ggctccfs	p.S367fs	POLG_ENST00000442287.2_Frame_Shift_Ins_p.S367fs	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	367					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TCTAAGGGAGGCCCCCCTACAT	0.559								DNA polymerases (catalytic subunits)					7	450	---	---	---	---					
FURIN	5045	broad.mit.edu	37	15	91424956	91424957	+	Frame_Shift_Ins	INS	-	-	G	rs35641241	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:91424956_91424957insG	ENST00000268171.3	+	16	2512_2513	c.2233_2234insG	c.(2233-2235)gggfs	p.G745fs		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	745					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.R745L(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CTTTAGTTTTCGGGGGGTGAAG	0.619													13	673	---	---	---	---					
LINS	55180	broad.mit.edu	37	15	101109855	101109856	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr15:101109855_101109856insG	ENST00000314742.8	-	7	2083_2084	c.1861_1862insC	c.(1861-1863)ggcfs	p.G621fs		NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	621								p.R621fs*13(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						TTGAGAGGCCCGGGGGGAAGAC	0.525													7	755	---	---	---	---					
DPEP2	64174	broad.mit.edu	37	16	68021467	68021468	+	Frame_Shift_Ins	INS	-	-	G	rs1133090	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr16:68021467_68021468insG	ENST00000412757.2	-	12	2067_2068	c.1402_1403insC	c.(1402-1404)catfs	p.H468fs	DPEP2_ENST00000393847.1_Frame_Shift_Ins_p.H468fs|DPEP2_ENST00000572888.1_Frame_Shift_Ins_p.H468fs			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	468			H -> D (in dbSNP:rs1133090).		hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGGGGCCATGTGGGGGGAGGAC	0.545													17	1237	---	---	---	---					
NFATC3	4775	broad.mit.edu	37	16	68225520	68225521	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr16:68225520_68225521insG	ENST00000349223.5	+	9	3172_3173	c.2948_2949insG	c.(2947-2949)cggfs	p.R983fs	NFATC3_ENST00000575270.1_Frame_Shift_Ins_p.R983fs|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Frame_Shift_Ins_p.R983fs|NFATC3_ENST00000329524.4_Frame_Shift_Ins_p.R983fs	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	983					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AGTACGGGCCAGGGGGGTCTTT	0.505													8	1235	---	---	---	---					
SLC7A6	9057	broad.mit.edu	37	16	68325529	68325530	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr16:68325529_68325530insG	ENST00000566454.1	+	8	1256_1257	c.987_988insG	c.(985-990)ttggggfs	p.LG329fs	SLC7A6_ENST00000219343.6_Frame_Shift_Ins_p.LG329fs	NM_001076785.2	NP_001070253.1	Q92536	YLAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	329					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		TGTCCTGCTTTGGGGGCCTCAA	0.490													8	1945	---	---	---	---					
SLC35G6	643664	broad.mit.edu	37	17	7386029	7386030	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:7386029_7386030insC	ENST00000412468.2	+	2	841_842	c.726_727insC	c.(724-729)caccccfs	p.HP242fs	ZBTB4_ENST00000311403.4_Intron	NM_001102614.1	NP_001096084.1	P0C7Q6	AMCL3_HUMAN	solute carrier family 35, member G6	242						integral to membrane		p.P243S(1)									TTGTGCTGCAGCCCCCCGTGTT	0.599													7	290	---	---	---	---					
ARHGEF15	22899	broad.mit.edu	37	17	8218831	8218832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:8218831_8218832insC	ENST00000361926.3	+	7	1470_1471	c.1360_1361insC	c.(1360-1362)cccfs	p.P454fs	ARHGEF15_ENST00000421050.1_Frame_Shift_Ins_p.P454fs	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	454	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						GGACACGCTCACCCCCCGTGAT	0.629													9	888	---	---	---	---					
ARHGEF15	22899	broad.mit.edu	37	17	8224297	8224298	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:8224297_8224298insC	ENST00000361926.3	+	16	2622_2623	c.2512_2513insC	c.(2512-2514)cccfs	p.P838fs	ARHGEF15_ENST00000421050.1_Frame_Shift_Ins_p.P838fs	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	838					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CACCCCCAATGCCCCCCCACCC	0.574													16	212	---	---	---	---					
DNAH9	1770	broad.mit.edu	37	17	11687648	11687649	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:11687648_11687649insG	ENST00000262442.3	+	41	7921_7922	c.7853_7854insG	c.(7852-7854)cggfs	p.R2618fs	DNAH9_ENST00000454412.2_Frame_Shift_Ins_p.R2618fs	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2618	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.P2618P(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTCTCCTTCCCGGGGGCAGATG	0.530													8	720	---	---	---	---					
TRIM16L	147166	broad.mit.edu	37	17	18638351	18638351	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:18638351delT	ENST00000449552.2	+	7	2109	c.625delT	c.(625-627)acfs	p.Y209fs	TRIM16L_ENST00000395671.4_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000395902.3_Frame_Shift_Del_p.Y263fs|TRIM16L_ENST00000414850.2_Frame_Shift_Del_p.C121fs|TRIM16L_ENST00000572555.1_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000571708.1_Frame_Shift_Del_p.Y209fs|TRIM16L_ENST00000395672.2_Frame_Shift_Del_p.Y209fs			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like	209	B30.2/SPRY.					cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						GCAGAGTCTGTACCTGCACAG	0.612													8	87	---	---	---	---					
RPL23	9349	broad.mit.edu	37	17	37008858	37008859	+	Splice_Site	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:37008858_37008859insT	ENST00000479035.2	-	3	356_357	c.226_splice	c.e3+1	p.S75_splice	RPL23_ENST00000245857.5_Splice_Site_p.S16_splice|RPL23_ENST00000394333.1_Splice_Site_p.S75_splice|RPL23_ENST00000394332.1_Splice_Site_p.S75_splice|RPL23_ENST00000577407.1_Splice_Site_p.S75_splice	NM_000978.3	NP_000969.1	P62829	RL23_HUMAN	ribosomal protein L23	75					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			endometrium(2)|large_intestine(1)	3						TTTACTCACCCTTTTTTCTGAG	0.485													7	619	---	---	---	---					
STAC2	342667	broad.mit.edu	37	17	37373352	37373353	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:37373352_37373353insA	ENST00000333461.5	-	3	840_841	c.471_472insT	c.(469-474)tcaccafs	p.P158fs		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	158					intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						CATTGCTGGTGGGAGATCTCCT	0.550													12	120	---	---	---	---					
SMARCE1	6605	broad.mit.edu	37	17	38787144	38787145	+	In_Frame_Ins	INS	-	-	ACT			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:38787144_38787145insACT	ENST00000348513.6	-	10	1628_1629	c.848_849insAGT	c.(847-849)gaa>gAGTaa	p.283_284ins*	SMARCE1_ENST00000377808.4_In_Frame_Ins_p.248_249ins*|SMARCE1_ENST00000544009.1_In_Frame_Ins_p.213_214ins*|SMARCE1_ENST00000580419.1_In_Frame_Ins_p.248_249ins*|SMARCE1_ENST00000578044.1_In_Frame_Ins_p.213_214ins*|SMARCE1_ENST00000431889.2_In_Frame_Ins_p.265_266ins*|SMARCE1_ENST00000400122.3_In_Frame_Ins_p.213_214ins*|KRT222_ENST00000476049.1_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	283					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				CTGCAATTTTCTCCATATCCAC	0.450													10	189	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													10	128	---	---	---	---					
CLTC	1213	broad.mit.edu	37	17	57733326	57733327	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:57733326_57733327insT	ENST00000269122.3	+	6	1181_1182	c.907_908insT	c.(907-909)tttfs	p.F303fs	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Frame_Shift_Ins_p.F303fs	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	303	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGGAGAAACAATTTTTGTTACT	0.371			T	"""ALK, TFE3"""	"""ALCL, renal """								222	155	---	---	---	---					
PRKCA	5578	broad.mit.edu	37	17	64683327	64683328	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:64683327_64683328insA	ENST00000413366.3	+	6	654_655	c.628_629insA	c.(628-630)aaafs	p.K210fs		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	210	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	TGAAAGCAAGCAAAAAACCAAA	0.401													9	370	---	---	---	---					
KIAA0195	9772	broad.mit.edu	37	17	73493880	73493881	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:73493880_73493881insC	ENST00000314256.7	+	27	3820_3821	c.3426_3427insC	c.(3424-3429)aaccccfs	p.NP1142fs	KIAA0195_ENST00000579208.1_Frame_Shift_Ins_p.NP793fs|KIAA0195_ENST00000375248.5_Frame_Shift_Ins_p.NP1152fs	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1142					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGCTGGGGAAGCCCCCCCATAG	0.520													89	2207	---	---	---	---					
RNF157	114804	broad.mit.edu	37	17	74155492	74155493	+	Frame_Shift_Ins	INS	-	-	G	rs111326194	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:74155492_74155493insG	ENST00000269391.6	-	12	1359_1360	c.1227_1228insC	c.(1225-1230)cctcagfs	p.Q410fs	RNF157_ENST00000319945.6_Frame_Shift_Ins_p.Q410fs	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	410							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			ATCGTCCTGACGGGGGGCAGGT	0.584													7	255	---	---	---	---					
TBCD	6904	broad.mit.edu	37	17	80758858	80758860	+	Translation_Start_Site	DEL	GGT	GGT	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr17:80758858_80758860delGGT	ENST00000397466.2	+	0	1045_1047				TBCD_ENST00000539345.2_In_Frame_Del_p.KV312del|TBCD_ENST00000355528.4_In_Frame_Del_p.KV312del			Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TGAAGCCGAAGGTGGCAGCATGG	0.675													7	36	---	---	---	---					
CEP192	55125	broad.mit.edu	37	18	13113612	13113613	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr18:13113612_13113613insG	ENST00000506447.1	+	41	7155_7156	c.7075_7076insG	c.(7075-7077)gggfs	p.G2359fs	CEP192_ENST00000325971.8_Frame_Shift_Ins_p.G1763fs|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Frame_Shift_Ins_p.G1884fs	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1954										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCCCAGAGGTAGGGGGGATTAT	0.426													7	309	---	---	---	---					
TRAPPC8	22878	broad.mit.edu	37	18	29437545	29437546	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr18:29437545_29437546insGG	ENST00000283351.4	-	20	3480_3481	c.3145_3146insCC	c.(3145-3147)tttfs	p.F1049fs	TRAPPC8_ENST00000582539.1_Frame_Shift_Ins_p.F995fs	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	1049					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GTAAAACAAAAAGTTAATTTCA	0.376													19	149	---	---	---	---					
ATP8B1	5205	broad.mit.edu	37	18	55317669	55317669	+	Frame_Shift_Del	DEL	G	G	-	rs112600442		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr18:55317669delG	ENST00000536015.1	-	27	3580	c.3461delC	c.(3460-3462)gtfs	p.A1154fs	RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA|RP11-35G9.3_ENST00000592201.1_RNA|ATP8B1_ENST00000283684.4_Frame_Shift_Del_p.A1154fs|RP11-35G9.3_ENST00000591854.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	1154					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TAAGCACACAGCAACAGCCAG	0.433													21	400	---	---	---	---					
LRG1	116844	broad.mit.edu	37	19	4538452	4538453	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:4538452_4538453insG	ENST00000306390.6	-	2	1003_1004	c.543_544insC	c.(541-546)ccggctfs	p.A182fs	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	182						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCAGCCCGGGGGGCAGTT	0.619													9	369	---	---	---	---					
ZNRF4	148066	broad.mit.edu	37	19	5456529	5456530	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:5456529_5456530insC	ENST00000222033.4	+	1	1104_1105	c.1027_1028insC	c.(1027-1029)cccfs	p.P343fs		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	343						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTTCTCCCAAGCCCCCCGGCGC	0.609													7	210	---	---	---	---					
AP1M1	8907	broad.mit.edu	37	19	16314383	16314384	+	Frame_Shift_Ins	INS	-	-	G	rs146546344	byFrequency	TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:16314383_16314384insG	ENST00000291439.3	+	2	605_606	c.156_157insG	c.(154-159)caggggfs	p.QG52fs	AP1M1_ENST00000541844.1_Intron|AP1M1_ENST00000429941.2_Frame_Shift_Ins_p.QG52fs|AP1M1_ENST00000590756.1_Intron|AP1M1_ENST00000444449.2_Frame_Shift_Ins_p.QG52fs	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	52					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TCCTGGCCCACGGGGGGGTCCG	0.594													11	371	---	---	---	---					
HAUS5	23354	broad.mit.edu	37	19	36113838	36113840	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:36113838_36113840delCCA	ENST00000203166.5	+	19	1870_1872	c.1845_1847delCCA	c.(1843-1848)ccg>cc	p.PQ615del	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	615					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						TGTCCCTGCCCCAGTGGCGGCTG	0.655													13	121	---	---	---	---					
ZBTB32	27033	broad.mit.edu	37	19	36205537	36205538	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:36205537_36205538insC	ENST00000392197.2	+	3	327_328	c.9_10insC	c.(7-12)ctccccfs	p.LP3fs	ZBTB32_ENST00000262630.3_Frame_Shift_Ins_p.LP3fs			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	3					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAATGTCCCTGCCCCCCATAAG	0.569													7	547	---	---	---	---					
HCST	10870	broad.mit.edu	37	19	36393526	36393527	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:36393526_36393527insT	ENST00000246551.4	+	1	145_146	c.31_32insT	c.(31-33)tttfs	p.F11fs	HCST_ENST00000437550.2_Frame_Shift_Ins_p.F11fs			Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer	11					regulation of immune response	integral to membrane|plasma membrane				lung(4)	4	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCTTCCTGCTTTTGCTCCCA	0.584													9	1375	---	---	---	---					
FCGBP	8857	broad.mit.edu	37	19	40433028	40433028	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:40433028delC	ENST00000221347.6	-	2	1248	c.1241delG	c.(1240-1242)gafs	p.G414fs		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	414	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGTGAGCAGTCCCAAGTTGGT	0.597													19	187	---	---	---	---					
EHD2	30846	broad.mit.edu	37	19	48244286	48244287	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:48244286_48244287insG	ENST00000263277.3	+	6	1480_1481	c.1229_1230insG	c.(1228-1230)cggfs	p.R410fs	EHD2_ENST00000540884.1_3'UTR|EHD2_ENST00000538399.1_Frame_Shift_Ins_p.R274fs	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	410					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GTGGGCGTGCAGGGGGGCGCTT	0.673													8	271	---	---	---	---					
CPT1C	126129	broad.mit.edu	37	19	50216300	50216301	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:50216300_50216301insA	ENST00000392518.4	+	19	2577_2578	c.2205_2206insA	c.(2203-2208)agaaaafs	p.RK735fs	CPT1C_ENST00000598293.1_Frame_Shift_Ins_p.RK735fs|CPT1C_ENST00000405931.2_Frame_Shift_Ins_p.RK724fs|CPT1C_ENST00000354199.5_Frame_Shift_Ins_p.RK646fs|CPT1C_ENST00000323446.5_Frame_Shift_Ins_p.RK735fs	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	735					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		ACATCTCCAGCAAAAAATCAAG	0.505													8	1054	---	---	---	---					
ZNF528	84436	broad.mit.edu	37	19	52919519	52919519	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:52919519delA	ENST00000360465.3	+	7	1840	c.1414delA	c.(1414-1416)aafs	p.K472fs	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AGAATGTGGCAAAGTCTTCAG	0.398													9	358	---	---	---	---					
KIR2DL4	3805	broad.mit.edu	37	19	55324675	55324675	+	Frame_Shift_Del	DEL	A	A	-	rs148484482		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr19:55324675delA	ENST00000396284.2	+	6	796	c.796delA	c.(796-798)aafs	p.K268fs	KIR2DL4_ENST00000346587.4_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396293.1_Intron|KIR2DL4_ENST00000357494.4_Intron|KIR2DL4_ENST00000463062.1_3'UTR|KIR2DL4_ENST00000345540.5_Intron|KIR2DL4_ENST00000359085.4_Frame_Shift_Del_p.K270fs					killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4									p.M271fs*>3(1)		NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CTGGTGCTCCAAAAAAAAAGT	0.532													11	1376	---	---	---	---					
TBC1D10A	83874	broad.mit.edu	37	22	30691731	30691732	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr22:30691731_30691732insC	ENST00000215790.7	-	4	682_683	c.518_519insG	c.(517-519)gcafs	p.A173fs	RP1-130H16.18_ENST00000447976.1_Frame_Shift_Ins_p.A47fs|TBC1D10A_ENST00000403362.1_Frame_Shift_Ins_p.A85fs|TBC1D10A_ENST00000403477.3_Frame_Shift_Ins_p.A180fs	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	173	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CTCACCCGTGGCCCCCCCGGGA	0.609													7	122	---	---	---	---					
POLR2F	5435	broad.mit.edu	37	22	38363690	38363691	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr22:38363690_38363691insG	ENST00000442738.2	+	5	477_478	c.352_353insG	c.(352-354)gggfs	p.G118fs	POLR2F_ENST00000407936.1_Intron|POLR2F_ENST00000405557.1_Intron|POLR2F_ENST00000470701.1_Frame_Shift_Ins_p.G113fs|POLR2F_ENST00000484894.1_Intron	NM_021974.3	NP_068809.1	P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F	118					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					CTATGAAGACTGGGGGGTGGAC	0.515													8	351	---	---	---	---					
TTLL1	25809	broad.mit.edu	37	22	43471583	43471584	+	Frame_Shift_Ins	INS	-	-	C	rs79088468		TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chr22:43471583_43471584insC	ENST00000331018.7	-	3	249_250	c.9_10insG	c.(7-12)ggaagtfs	p.S4fs	TTLL1_ENST00000266254.7_Frame_Shift_Ins_p.S4fs|TTLL1_ENST00000445824.1_Frame_Shift_Ins_p.S4fs			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	4	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		CATTTTACTTTCCCTGCCATAA	0.401													8	1478	---	---	---	---					
SLC9A7	84679	broad.mit.edu	37	X	46529118	46529118	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chrX:46529118delA	ENST00000328306.4	-	5	742	c.717delT	c.(715-717)atfs	p.I239fs		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	239					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GCTGTCCCATAATCTTCATGA	0.383													8	208	---	---	---	---					
NSDHL	50814	broad.mit.edu	37	X	152037406	152037407	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AS-3778-01A-01W-0886-08	TCGA-AS-3778-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92941393-2b36-4cf5-ab01-f1ba3f8f15df	851ae5d5-c3ea-4108-93ea-e383ea566af3	g.chrX:152037406_152037407insC	ENST00000370274.3	+	8	1062_1063	c.868_869insC	c.(868-870)cccfs	p.P290fs	NSDHL_ENST00000440023.1_Frame_Shift_Ins_p.P290fs	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	290					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	CAATTATGAGGCCCCCAAGTAC	0.559													7	1649	---	---	---	---