Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C4B	721	broad.mit.edu	37	6	31997537	31997537	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr6:31997537C>T	ENST00000435363.2	+	29	3955	c.3871C>T	c.(3871-3873)Cgt>Tgt	p.R1291C	C4B_ENST00000425700.2_Missense_Mutation_p.R1291C	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1291					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										CTGGCTCACCCGTCAGGGCAG	0.652000													10	165					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32972827	32972827	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr13:32972827G>C	ENST00000544455.1	+	27	10404	c.10177G>C	c.(10177-10179)Gaa>Caa	p.E3393Q	BRCA2_ENST00000380152.3_Missense_Mutation_p.E3393Q	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3393					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCTGATCAAAGAACAGGAGAG	0.388000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			18	76					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													5	155					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169196507	169196507	+	Missense_Mutation	SNP	C	C	T	rs145382015		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr4:169196507C>T	ENST00000393743.3	-	16	2584	c.2293G>A	c.(2293-2295)Gac>Aac	p.D765N		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	765							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGCCATGTGTCGGGAATAAAA	0.403000													4	127					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30576880	30576880	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr6:30576880C>T	ENST00000376511.2	-	4	720	c.168G>A	c.(166-168)caG>caA	p.Q56Q		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	56	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						GTGAACGGGTCTGCAGGAGAA	0.488000													42	112					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44683556	44683556	+	Splice_Site	SNP	A	A	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:44683556A>G	ENST00000454036.1	+	21	2826	c.2748_splice	c.e21-1	p.H917_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.H894_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	917					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCCCACAGCATGAGAGCGAC	0.547000													23	27					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139874684	139874684	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr9:139874684C>G	ENST00000224167.2	+	5	675	c.600C>G	c.(598-600)ttC>ttG	p.F200L	PTGDS_ENST00000371625.3_Missense_Mutation_p.F166L			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	166					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TCACCGCCTTCTGCAAGGCCC	0.597000													16	47					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109382704	109382704	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:109382704G>A	ENST00000283195.6	+	20	5835	c.5709G>A	c.(5707-5709)tcG>tcA	p.S1903S		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1903					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TTGGCATTTCGGAACCAGGAA	0.403000													113	388					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43174753	43174753	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr5:43174753G>A	ENST00000509634.1	+	7	1744	c.1288G>A	c.(1288-1290)Gaa>Aaa	p.E430K	ZNF131_ENST00000505606.2_Missense_Mutation_p.E430K|ZNF131_ENST00000509156.1_Missense_Mutation_p.E464K|ZNF131_ENST00000399534.1_Missense_Mutation_p.E464K|ZNF131_ENST00000509931.1_Intron|ZNF131_ENST00000306938.4_Missense_Mutation_p.E430K			P52739	ZN131_HUMAN	zinc finger protein 131	464						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						TGTGCAAACTGAACCTGTAAC	0.423000													29	124					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54930406	54930406	+	Silent	SNP	C	C	T	rs148537788		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:54930406C>T	ENST00000301194.4	+	2	353	c.231C>T	c.(229-231)ccC>ccT	p.P77P	TTYH1_ENST00000391739.3_Silent_p.P126P|TTYH1_ENST00000376531.3_Silent_p.P77P|TTYH1_ENST00000376530.3_Silent_p.P77P			Q9H313	TTYH1_HUMAN	tweety family member 1	77					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CCCCCGAGCCCCCCGGGTCCA	0.697000													16	47					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242142813	242142813	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:242142813C>G	ENST00000274979.8	+	9	1054	c.951C>G	c.(949-951)ttC>ttG	p.F317L	ANO7_ENST00000402430.3_Missense_Mutation_p.F316L	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	317						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						AAGTCCTTTTCCAGCACTGGG	0.687000													4	11					0	0	1	0	0
HMGN2P46	283651	broad.mit.edu	37	15	45848224	45848224	+	RNA	SNP	G	G	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr15:45848224G>T	ENST00000409454.1	+	0	1219																											TGCAGATTTTGTTTAGCTTTT	0.318000													6	25					5.18039e-06	5.3475e-06	1	1	0
ENTHD1	150350	broad.mit.edu	37	22	40139838	40139838	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:40139838C>T	ENST00000325157.6	-	7	1920	c.1670G>A	c.(1669-1671)cGt>cAt	p.R557H		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	557										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					AGCGATCGCACGTTTTACCTC	0.403000													17	65					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109477468	109477468	+	Missense_Mutation	SNP	C	C	T	rs144141792	byFrequency	TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:109477468C>T	ENST00000369971.2	-	11	1609	c.1480G>A	c.(1480-1482)Gcc>Acc	p.A494T	CLCC1_ENST00000356970.2_Missense_Mutation_p.A494T|CLCC1_ENST00000348264.2_Missense_Mutation_p.A309T|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000369976.1_Intron|CLCC1_ENST00000482889.1_Intron|CLCC1_ENST00000302500.4_Missense_Mutation_p.A373T|CLCC1_ENST00000415331.1_Missense_Mutation_p.A444T|CLCC1_ENST00000369968.2_Missense_Mutation_p.A309T|CLCC1_ENST00000369969.2_Missense_Mutation_p.A373T|CLCC1_ENST00000369970.3_Missense_Mutation_p.A444T	NM_001048210.1	NP_001041675.1	Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	494						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		ACAGGCTTGGCCGACTGGCTG	0.542000													4	142					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50052279	50052279	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:50052279G>A	ENST00000376042.1	+	6	1408	c.1110G>A	c.(1108-1110)aaG>aaA	p.K370K	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000276014.7_Silent_p.K370K|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	370					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TAGCCTTTAAGAAGAAGCCTA	0.458000													18	70					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68607996	68607996	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:68607996A>T	ENST00000234313.7	+	3	519	c.340A>T	c.(340-342)Acc>Tcc	p.T114S		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	114					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CAGGAAATCTACCAGGAGGTC	0.463000													52	190					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			19	59					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330480	125330480	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr9:125330480T>C	ENST00000304865.2	-	1	358	c.277A>G	c.(277-279)Atc>Gtc	p.I93V		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GCATAGGAGATGGTCTTCTTT	0.453000													23	59					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157019	22157019	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:22157019T>A	ENST00000397126.4	-	4	965	c.817A>T	c.(817-819)Act>Tct	p.T273S	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTATGTTTAGTAAGGATTGCA	0.358000													18	74					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105451255	105451255	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:105451255G>A	ENST00000337685.2	+	5	2615	c.1830G>A	c.(1828-1830)gtG>gtA	p.V610V	MUM1L1_ENST00000372552.1_Silent_p.V610V|MUM1L1_ENST00000357175.2_Silent_p.V610V	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	610										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATGAAGTGGTGAAATATTTAC	0.333000													9	32					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23619391	23619391	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr18:23619391G>C	ENST00000415083.2	-	6	692	c.637C>G	c.(637-639)Cag>Gag	p.Q213E	SS18_ENST00000545952.1_Missense_Mutation_p.Q161E|SS18_ENST00000542743.1_Missense_Mutation_p.Q161E|SS18_ENST00000539849.1_Missense_Mutation_p.Q131E|SS18_ENST00000269137.7_Missense_Mutation_p.Q213E|SS18_ENST00000542420.2_Missense_Mutation_p.Q190E|SS18_ENST00000585241.1_5'UTR	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	213	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding	p.Q213E(1)	SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TTGTATTGCTGAGAAGGAGGC	0.408000			T	"""SSX1,  SSX2"""	synovial sarcoma								25	115					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763501	763501	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:763501G>A	ENST00000319006.3	+	5	772	c.619G>A	c.(619-621)Gag>Aag	p.E207K	TALDO1_ENST00000528097.1_Missense_Mutation_p.E207K			P37837	TALDO_HUMAN	transaldolase 1	207					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GAAATCCTATGAGCCCCTGGA	0.612000													56	221					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39877390	39877390	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:39877390G>A	ENST00000530275.1	+	1	1240	c.1045G>A	c.(1045-1047)Gag>Aag	p.E349K	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000289893.4_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	349										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCCTCTAGTTGAGCTACAGAA	0.418000													21	63					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100410411	100410411	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:100410411G>A	ENST00000358173.3	-	12	2544	c.2076C>T	c.(2074-2076)ctC>ctT	p.L692L	EPHB4_ENST00000360620.3_Silent_p.L692L	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	692	Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGAACTCTGTGAGAATCATGA	0.617000													15	55					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705410	112705410	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr9:112705410T>A	ENST00000448454.2	+	8	947	c.947T>A	c.(946-948)tTt>tAt	p.F316Y	PALM2_ENST00000374531.2_Missense_Mutation_p.F282Y|PALM2_ENST00000483909.1_Missense_Mutation_p.F280Y|PALM2_ENST00000314527.4_Missense_Mutation_p.F314Y|AKAP2_ENST00000510514.5_Intron|PALM2-AKAP2_ENST00000374530.3_Intron|AKAP2_ENST00000555236.1_Intron|PALM2-AKAP2_ENST00000302798.7_Intron					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						ACCATGATTTTTATGGGCTAC	0.512000													22	67					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96521762	96521762	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:96521762T>A	ENST00000456556.1	-	63	4331	c.4247A>T	c.(4246-4248)aAg>aTg	p.K1416M	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.K667M|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.K443M					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTTTAGAGCCTTTTGAAGGTC	0.388000													3	23					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236749198	236749198	+	Silent	SNP	G	G	T	rs140333539		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:236749198G>T	ENST00000366582.3	-	16	2085	c.1971C>A	c.(1969-1971)atC>atA	p.I657I	HEATR1_ENST00000366581.2_Silent_p.I657I	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	657					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTGCTACACCGATTAGTTTTC	0.348000													15	51					1.3612e-06	1.42815e-06	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31325299	31325299	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr18:31325299G>C	ENST00000269197.5	+	12	5487	c.5487G>C	c.(5485-5487)aaG>aaC	p.K1829N		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ACCCCAAAAAGAGAGTAGCTA	0.473000													70	215					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763491	763491	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:763491G>A	ENST00000319006.3	+	5	762	c.609G>A	c.(607-609)aaG>aaA	p.K203K	TALDO1_ENST00000528097.1_Silent_p.K203K			P37837	TALDO_HUMAN	transaldolase 1	203					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		ACACCGACAAGAAATCCTATG	0.602000													57	237					0	0	1	0	0
GNAI2	2771	broad.mit.edu	37	3	50289829	50289829	+	Splice_Site	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:50289829G>A	ENST00000313601.6	+	3	546	c.161_splice	c.e3-1	p.K54_splice	GNAI2_ENST00000440628.1_Splice_Site_p.K2_splice|GNAI2_ENST00000451956.1_Splice_Site_p.K17_splice|GNAI2_ENST00000266027.5_Splice_Site_p.K38_splice|GNAI2_ENST00000536647.1_5'UTR|GNAI2_ENST00000422163.1_Splice_Site_p.K38_splice|GNAI2_ENST00000491100.1_3'UTR	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	54					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		TGGCTATCAGGATCATCCACG	0.587000													19	61					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7699805	7699805	+	Silent	SNP	C	C	T	rs148588175	byFrequency	TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr17:7699805C>T	ENST00000572933.1	+	50	9158	c.7698C>T	c.(7696-7698)ttC>ttT	p.F2566F	DNAH2_ENST00000389173.2_Silent_p.F2566F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2566	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCCGCATATTCGGCACCATGA	0.542000													16	54					0	0	1	0	0
EIF2A	83939	broad.mit.edu	37	3	150301645	150301645	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:150301645C>T	ENST00000460851.1	+	14	1814	c.1705C>T	c.(1705-1707)Cag>Tag	p.Q569*	EIF2A_ENST00000273435.5_Nonsense_Mutation_p.Q564*|EIF2A_ENST00000383043.3_Nonsense_Mutation_p.Q355*|SERP1_ENST00000490945.1_Intron|EIF2A_ENST00000487799.1_Nonsense_Mutation_p.Q544*|EIF2A_ENST00000406576.3_Nonsense_Mutation_p.Q508*|EIF2A_ENST00000482471.1_3'UTR|SERP1_ENST00000479209.1_Intron			Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A, 65kDa	569					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding			cervix(1)|endometrium(2)|kidney(1)|lung(3)	7		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGAGAAAATTCAGAAAGAAAC	0.328000													8	28					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40364245	40364245	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:40364245A>T	ENST00000344138.4	+	6	922	c.659A>T	c.(658-660)cAg>cTg	p.Q220L	GRAP2_ENST00000399090.2_Missense_Mutation_p.Q107L|GRAP2_ENST00000540310.1_Missense_Mutation_p.Q154L|GRAP2_ENST00000544756.1_Missense_Mutation_p.Q148L|GRAP2_ENST00000407075.3_Missense_Mutation_p.Q220L|GRAP2_ENST00000543252.1_Missense_Mutation_p.Q180L	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	220					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						cccccacagcagcgatatctg	0.642000													7	37					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763465	763465	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:763465G>C	ENST00000319006.3	+	5	736	c.583G>C	c.(583-585)Gat>Cat	p.D195H	TALDO1_ENST00000528097.1_Missense_Mutation_p.D195H			P37837	TALDO_HUMAN	transaldolase 1	195					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GCGCATCCTTGATTGGCATGT	0.577000													58	258					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839353	62839353	+	Silent	SNP	A	A	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:62839353A>G	ENST00000536311.1	+	7	1168	c.804A>G	c.(802-804)gaA>gaG	p.E268E	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Silent_p.E268E			Q01538	MYT1_HUMAN	myelin transcription factor 1	268	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E268E(2)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaggaggaagaggaggagg	0.572000													3	27					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107688432	107688432	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:107688432G>A	ENST00000388781.3	-	28	4330	c.4247C>T	c.(4246-4248)aCg>aTg	p.T1416M	LAMB4_ENST00000205386.4_Missense_Mutation_p.T1416M|LAMB4_ENST00000388780.3_Missense_Mutation_p.T1416M	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1416	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GAGGGCATTCGTTGAGAGGGT	0.532000													7	166					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823900	70823900	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:70823900G>A	ENST00000373695.1	+	7	1310	c.773G>A	c.(772-774)aGc>aAc	p.S258N	ACRC_ENST00000373696.3_Missense_Mutation_p.S258N			Q96QF7	ACRC_HUMAN	acidic repeat containing	258	Asp/Ser-rich.					nucleus		p.S258N(2)		autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CCCGACGACAGCAGTGATGAT	0.557000													7	255					0	0	1	0	0
FBXO32	114907	broad.mit.edu	37	8	124515703	124515703	+	Splice_Site	SNP	C	C	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr8:124515703C>A	ENST00000517956.1	-	9	1170		c.e9-1		FBXO32_ENST00000443022.2_Splice_Site	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32											autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GGTCAGTGCCCTGGAAAGGAA	0.468000													4	59					2.56e-06	2.66407e-06	1	1	0
COL20A1	57642	broad.mit.edu	37	20	61943054	61943054	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:61943054G>A	ENST00000422202.1	+	12	1706	c.1638G>A	c.(1636-1638)ctG>ctA	p.L546L	COL20A1_ENST00000326996.6_Silent_p.L539L|COL20A1_ENST00000435874.1_Silent_p.L546L|COL20A1_ENST00000358894.6_Silent_p.L539L			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	539	Fibronectin type-III 3.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					TGCAGAGCCTGCGAGGCCCTG	0.697000													11	13					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72691256	72691256	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr17:72691256G>T	ENST00000326165.6	-	7	963	c.852C>A	c.(850-852)taC>taA	p.Y284*	RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000343125.4_3'UTR|CD300LF_ENST00000361254.4_3'UTR|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000469092.1_3'UTR|CD300LF_ENST00000301573.9_3'UTR|CD300LF_ENST00000464910.1_Nonsense_Mutation_p.Y287*|CD300LF_ENST00000583937.1_Nonsense_Mutation_p.Y299*	NM_139018.3	NP_620587.2	Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	284						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						TGATGGTGCTGTATTCCGTGG	0.637000													8	49					0.00307968	0.00307968	1	1	0
LRRN4	164312	broad.mit.edu	37	20	6032876	6032876	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:6032876G>A	ENST00000378858.4	-	2	794	c.570C>T	c.(568-570)atC>atT	p.I190I		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	190						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						CCGCCTCGGCGATGCCCCCCT	0.731000													6	10					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61830997	61830997	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr10:61830997C>T	ENST00000280772.1	-	37	9833	c.9642G>A	c.(9640-9642)aaG>aaA	p.K3214K	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3214					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGGAGGTTGACTTGGCCTGTT	0.473000													27	156					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509636	106509636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:106509636C>T	ENST00000359195.3	+	2	1940	c.1630C>T	c.(1630-1632)Cga>Tga	p.R544*	PIK3CG_ENST00000496166.1_Nonsense_Mutation_p.R544*|PIK3CG_ENST00000440650.2_Nonsense_Mutation_p.R544*	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	544					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGACCGGGTTCGAGCAGAAAT	0.542000													29	75					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				27	86					0	0	1	0	0
ATP6V1C1	528	broad.mit.edu	37	8	104061168	104061168	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr8:104061168C>A	ENST00000395862.3	+	4	430	c.271C>A	c.(271-273)Ctg>Atg	p.L91M	ATP6V1C1_ENST00000521514.1_Missense_Mutation_p.L16M|ATP6V1C1_ENST00000518857.1_Missense_Mutation_p.L16M|ATP6V1C1_ENST00000518738.1_Missense_Mutation_p.L91M	NM_001695.4	NP_001686.1	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	91					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			TCAAGAGAATCTGTTGGCTAA	0.333000													38	60					1.07637e-12	1.13864e-12	1	1	0
DOT1L	84444	broad.mit.edu	37	19	2220106	2220106	+	Splice_Site	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:2220106G>C	ENST00000398665.3	+	23	2727		c.e23-1			NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase							nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCTCTGCAGAGGAGCACCC	0.622000													8	34					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13538828	13538828	+	Nonsense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr10:13538828G>C	ENST00000341083.3	-	4	649	c.353C>G	c.(352-354)tCa>tGa	p.S118*	BEND7_ENST00000378605.3_Nonsense_Mutation_p.S131*|BEND7_ENST00000396898.2_Nonsense_Mutation_p.S183*|BEND7_ENST00000396900.2_Nonsense_Mutation_p.S170*	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	170							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						CTGCAACGTTGACTGGCAGTT	0.423000													26	83					0	0	1	0	0
LAG3	3902	broad.mit.edu	37	12	6883996	6883996	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr12:6883996C>G	ENST00000203629.2	+	4	1080	c.747C>G	c.(745-747)ttC>ttG	p.F249L	LAG3_ENST00000441671.2_Missense_Mutation_p.F249L	NM_002286.5	NP_002277.4	P18627	LAG3_HUMAN	lymphocyte-activation gene 3	249	Ig-like C2-type 1.					integral to membrane	antigen binding|MHC class II protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GAGATGGCTTCAACGTCTCCA	0.567000													21	79					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134993810	134993810	+	Nonsense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:134993810C>G	ENST00000535938.1	+	18	2386	c.2219C>G	c.(2218-2220)tCa>tGa	p.S740*	SAGE1_ENST00000324447.3_Nonsense_Mutation_p.S740*|SAGE1_ENST00000370709.3_Nonsense_Mutation_p.S740*|SAGE1_ENST00000537770.1_Nonsense_Mutation_p.S364*	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	740										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GGCTTCCTGTCAAATTCTGAT	0.423000													66	240					0	0	1	0	0
TNFRSF6B	8771	broad.mit.edu	37	20	62328212	62328212	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:62328212C>T	ENST00000369996.1	+	1	192	c.92C>T	c.(91-93)gCa>gTa	p.A31V	RTEL1_ENST00000318100.4_Silent_p.G1333G|RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.G1333G	NM_003823.3	NP_003814.1	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily, member 6b, decoy	31					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|lung(2)|skin(1)	4	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			CGCGGAGTGGCAGAAACACCC	0.716000													4	20					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53449623	53449623	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr12:53449623C>T	ENST00000314250.6	+	10	1045	c.755C>T	c.(754-756)tCt>tTt	p.S252F	TENC1_ENST00000314276.3_Missense_Mutation_p.S262F|TENC1_ENST00000552570.1_Missense_Mutation_p.S252F|TENC1_ENST00000379902.3_Missense_Mutation_p.S128F|TENC1_ENST00000546602.1_Missense_Mutation_p.S252F|TENC1_ENST00000549700.1_Missense_Mutation_p.S252F|TENC1_ENST00000451358.1_Missense_Mutation_p.S252F	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	252	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						AGCAAGATCTCTGCAGGGTGA	0.597000													48	135					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17056393	17056393	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:17056393C>T	ENST00000418129.2	+	3	3095	c.2630C>T	c.(2629-2631)aCt>aTt	p.T877I	PLCL2_ENST00000432376.1_Missense_Mutation_p.T877I|PLCL2_ENST00000396755.2_Missense_Mutation_p.T877I	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1003					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						ATCGTAACAACTTATGACATG	0.478000													30	111					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53854494	53854494	+	Missense_Mutation	SNP	C	C	G	rs138639565	by1000genomes	TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:53854494C>G	ENST00000458035.1	+	4	683	c.566C>G	c.(565-567)tCt>tGt	p.S189C	ZNF845_ENST00000595091.1_Missense_Mutation_p.S189C	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ACCCACATTTCTAAGAACTAT	0.368000													44	147					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56180837	56180837	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:56180837C>T	ENST00000450554.2	+	11	2019	c.1060C>T	c.(1060-1062)Ctg>Ttg	p.L354L	U2AF2_ENST00000308924.4_Silent_p.L358L|U2AF2_ENST00000590551.1_Silent_p.L190L|CTD-2537I9.12_ENST00000589456.1_RNA|CTD-2537I9.12_ENST00000585940.1_RNA	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	358					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GCCTGTGACCCTGCAAGTGCC	0.657000													10	41					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310352	24310352	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:24310352C>G	ENST00000357002.4	+	4	1665	c.1550C>G	c.(1549-1551)cCc>cGc	p.P517R	ZNF254_ENST00000342944.6_Missense_Mutation_p.P432R	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	517					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GGAGAGAAACCCTACAAATGT	0.368000													5	160					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17083655	17083655	+	RNA	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:17083655G>A	ENST00000455405.2	-	0	933																											tctcaaccttgagtacaagtc	0.393000													5	62					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33870417	33870417	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:33870417G>A	ENST00000307296.3	+	7	1167	c.790G>A	c.(790-792)Gca>Aca	p.A264T	PDCD6IP_ENST00000457054.2_Missense_Mutation_p.A269T			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	264	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						GTCTATCCTGGCAAAACAGCA	0.408000													4	144					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763351	763351	+	Missense_Mutation	SNP	G	G	A	rs140952110		TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:763351G>A	ENST00000319006.3	+	5	622	c.469G>A	c.(469-471)Gag>Aag	p.E157K	TALDO1_ENST00000528097.1_Missense_Mutation_p.E157K			P37837	TALDO_HUMAN	transaldolase 1	157					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		CAGGGAGCTCGAGGAGCAGCA	0.697000													17	71					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3626701	3626701	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:3626701C>G	ENST00000429344.2	-	1	112	c.60G>C	c.(58-60)caG>caC	p.Q20H	CACTIN_ENST00000221899.3_5'UTR|CACTIN_ENST00000248420.5_Missense_Mutation_p.Q20H	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		CGCTCTGACTCTGCCGCCTTC	0.746000													3	8					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310305	24310305	+	Silent	SNP	A	A	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:24310305A>G	ENST00000357002.4	+	4	1618	c.1503A>G	c.(1501-1503)caA>caG	p.Q501Q	ZNF254_ENST00000342944.6_Silent_p.Q416Q	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	501					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				CTTTTAGCCAATCCTCAACCC	0.403000													5	139					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455354	179455354	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:179455354G>A	ENST00000589042.1	-	304	61322	c.61098C>T	c.(61096-61098)tgC>tgT	p.C20366C	TTN_ENST00000359218.5_Silent_p.C11426C|TTN_ENST00000460472.2_Silent_p.C11301C|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Silent_p.C11493C|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.C18725C|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Silent_p.C17798C|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18725	Fibronectin type-III 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGGGCCGGCAAGCTTTTA	0.433000													4	150					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614884	3614884	+	RNA	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:3614884C>T	ENST00000301749.7	-	0	559				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCCAGCGGGGCATCCGGTGTC	0.672000													13	27					0	0	1	0	0
RAB34	83871	broad.mit.edu	37	17	27042131	27042131	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr17:27042131G>A	ENST00000395245.3	-	8	1149	c.523C>T	c.(523-525)Cag>Tag	p.Q175*	RAB34_ENST00000447716.1_Nonsense_Mutation_p.Q232*|RAB34_ENST00000415040.2_Nonsense_Mutation_p.Q153*|RAB34_ENST00000301043.6_Nonsense_Mutation_p.Q175*|RAB34_ENST00000453384.3_Nonsense_Mutation_p.Q233*|RAB34_ENST00000450529.1_Nonsense_Mutation_p.Q167*|RAB34_ENST00000436730.3_Nonsense_Mutation_p.Q175*|RAB34_ENST00000395243.3_Nonsense_Mutation_p.Q167*|RAB34_ENST00000395242.2_Nonsense_Mutation_p.Q176*	NM_001256281.1|NM_031934.5	NP_001243210.1|NP_114140.4	Q9BZG1	RAB34_HUMAN	RAB34, member RAS oncogene family	175					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|skin(2)	14	Lung NSC(42;0.00431)					AGCGCATACTGAGCAGGGGTC	0.582000													21	80					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24988567	24988567	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:24988567C>A	ENST00000289968.6	-	3	236	c.167G>T	c.(166-168)gGc>gTc	p.G56V	ARHGAP17_ENST00000303665.5_Missense_Mutation_p.G56V|ARHGAP17_ENST00000575975.1_5'UTR|ARHGAP17_ENST00000441763.2_Missense_Mutation_p.G56V	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	56	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GCCATGCTGGCCCTGGAAACA	0.542000													16	46					5.3912e-06	5.52059e-06	1	1	0
HRH3	11255	broad.mit.edu	37	20	60791962	60791962	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:60791962C>T	ENST00000340177.5	-	3	722	c.438G>A	c.(436-438)caG>caA	p.Q146Q	HRH3_ENST00000317393.6_Silent_p.Q146Q	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	146					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	GCGTGTCACCCTGCTGGGCCC	0.677000													22	27					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145806379	145806379	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr8:145806379C>T	ENST00000276826.5	-	2	564	c.363G>A	c.(361-363)gaG>gaA	p.E121E	ARHGAP39_ENST00000377307.2_Silent_p.E121E|ARHGAP39_ENST00000540274.1_Silent_p.E121E			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	121					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CGGGGCTGCTCTCCGCCGAGG	0.711000													6	11					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70512982	70512982	+	Silent	SNP	A	A	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr4:70512982A>G	ENST00000503640.1	-	1	436	c.381T>C	c.(379-381)gaT>gaC	p.D127D	UGT2A1_ENST00000286604.4_Silent_p.D127D|UGT2A1_ENST00000512704.1_Silent_p.D127D|UGT2A1_ENST00000514019.1_Silent_p.D127D	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	127					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TAAGAACGCCATCACAGATCT	0.433000													20	114					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57758618	57758618	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:57758618G>C	ENST00000360716.3	+	13	1850	c.1629G>C	c.(1627-1629)gaG>gaC	p.E543D	CCDC135_ENST00000394337.4_Missense_Mutation_p.E543D|CCDC135_ENST00000336825.8_Missense_Mutation_p.E478D			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	543						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AGCGGGAGGAGACACCCAGGA	0.557000													10	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179567232	179567232	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:179567232C>T	ENST00000589042.1	-	107	30606	c.30382G>A	c.(30382-30384)Gat>Aat	p.D10128N	TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D9811N|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D8884N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9811	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCGGCCATCATTCCTGAAG	0.433000													73	261					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42143085	42143085	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr15:42143085C>T	ENST00000320955.6	-	66	11115	c.10888G>A	c.(10888-10890)Gag>Aag	p.E3630K		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3630	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CACCAGCTCTCAGCCTGCTCT	0.667000													4	2					0	0	1	0	0
ADAM8	101	broad.mit.edu	37	10	135083941	135083941	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr10:135083941C>T	ENST00000445355.3	-	16	1758	c.1708G>A	c.(1708-1710)Gtg>Atg	p.V570M	ADAM8_ENST00000415217.3_Missense_Mutation_p.V570M|ADAM8_ENST00000485491.2_Missense_Mutation_p.V531M	NM_001109.4	NP_001100.3	B4DVM6	B4DVM6_HUMAN	ADAM metallopeptidase domain 8	531					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)	17		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		GCGTGGCACACATCCACGATG	0.662000													18	62					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2995883	2995883	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr17:2995883C>G	ENST00000331459.1	-	1	407	c.408G>C	c.(406-408)atG>atC	p.M136I		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	136					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						GCTTAGGGCTCATGGCTGTGG	0.552000													35	74					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66102290	66102290	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:66102290G>A	ENST00000349533.6	+	20	3275	c.3090G>A	c.(3088-3090)gaG>gaA	p.E1030E	LEPR_ENST00000406510.3_Silent_p.E97E	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	1030					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GCTCATGGGAGATAGAGGCCC	0.388000													57	145					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987239	154987239	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:154987239G>A	ENST00000368426.3	+	3	240	c.103G>A	c.(103-105)Gac>Aac	p.D35N	ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000535420.1_Missense_Mutation_p.D35N|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.D69N|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.D35N	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	35	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCACCTATGTGACCTCACCAT	0.607000													27	89					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120745	38120745	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:38120745G>T	ENST00000406386.3	+	7	2437	c.2182G>T	c.(2182-2184)Gac>Tac	p.D728Y	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	728					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TGCCCGACGGGACAATCCCAG	0.587000													26	108					4.87955e-14	5.20486e-14	1	1	0
ALPP	250	broad.mit.edu	37	2	233245430	233245430	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:233245430G>A	ENST00000392027.2	+	8	1232	c.963G>A	c.(961-963)ctG>ctA	p.L321L	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	321						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TGCGCCTGCTGAGCAGGAACC	0.637000													9	100					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7522148	7522148	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr12:7522148C>A	ENST00000313599.3	-	15	3901	c.3844G>T	c.(3844-3846)Gtg>Ttg	p.V1282L	CD163L1_ENST00000416109.2_Missense_Mutation_p.V1292L|CD163L1_ENST00000396630.1_Missense_Mutation_p.V1282L			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1282	SRCR 12.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TGACACACCACTTCCGCCTCG	0.632000													24	84					7.4402e-23	8.00291e-23	1	1	0
C6	729	broad.mit.edu	37	5	41199960	41199960	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr5:41199960C>T	ENST00000263413.3	-	4	619	c.355G>A	c.(355-357)Gcg>Acg	p.A119T	C6_ENST00000337836.5_Missense_Mutation_p.A119T	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	119	TSP type-1 2.		A -> E (in allotype C6 A; dbSNP:rs1801033).		complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACCAGAGGCGCAGTGCATGGC	0.453000													20	86					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142176529	142176529	+	Silent	SNP	A	A	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:142176529A>T	ENST00000350721.4	-	45	7693	c.7572T>A	c.(7570-7572)ggT>ggA	p.G2524G	ATR_ENST00000383101.3_Silent_p.G2460G	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2524	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTCCCATAGGACCCATTCCAT	0.393000								Other conserved DNA damage response genes					32	96					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33602351	33602351	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:33602351T>A	ENST00000399362.4	-	28	3253	c.2900A>T	c.(2899-2901)gAt>gTt	p.D967V	CLASP2_ENST00000359576.5_Missense_Mutation_p.D959V|CLASP2_ENST00000468888.2_Missense_Mutation_p.D968V|CLASP2_ENST00000539981.1_Missense_Mutation_p.D737V|CLASP2_ENST00000461133.3_Missense_Mutation_p.D727V|CLASP2_ENST00000307312.7_Missense_Mutation_p.D449V|CLASP2_ENST00000480013.1_Missense_Mutation_p.D747V	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	969										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TCCAAGCAAATCAGCACCCAT	0.338000													5	210					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906469	144906469	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chrX:144906469C>T	ENST00000370490.1	+	1	6781	c.2526C>T	c.(2524-2526)atC>atT	p.I842I	SLITRK2_ENST00000413937.2_Silent_p.I842I|SLITRK2_ENST00000447897.2_Silent_p.I842I|SLITRK2_ENST00000428560.2_Silent_p.I842I|SLITRK2_ENST00000434188.2_Silent_p.I842I			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	842						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					AAACTGCAATCAGTCAGCTGT	0.448000													30	79					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129371200	129371200	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr6:129371200C>T	ENST00000421865.2	+	2	299	c.250C>T	c.(250-252)Cga>Tga	p.R84*		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	84	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCCGCAGTGTCGAATCTGCAA	0.458000													24	70					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													4	120					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120199	38120199	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:38120199C>T	ENST00000406386.3	+	7	1891	c.1636C>T	c.(1636-1638)Cga>Tga	p.R546*	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	546					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TAGAGCTGCACGAGACAACCC	0.587000													6	378					0	0	1	0	0
MTDH	92140	broad.mit.edu	37	8	98703324	98703324	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr8:98703324C>T	ENST00000336273.3	+	6	1284	c.956C>T	c.(955-957)cCa>cTa	p.P319L	MTDH_ENST00000519934.1_Missense_Mutation_p.P296L	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	319					lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			AAAACTGAGCCATCTGCCTGG	0.458000													24	105					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175049481	175049481	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:175049481C>T	ENST00000239462.4	+	4	1080	c.967C>T	c.(967-969)Cct>Tct	p.P323S		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	323	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGGTTTGCTGCCTGGAACCAA	0.532000													6	72					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|SIRPB1_ENST00000381605.4_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													7	98					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110837604	110837604	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr3:110837604G>C	ENST00000485303.1	+	3	879	c.604G>C	c.(604-606)Gca>Cca	p.A202P	PVRL3_ENST00000319792.3_Missense_Mutation_p.A202P|PVRL3_ENST00000493615.1_Missense_Mutation_p.A179P	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	202	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						AAAACCCGTTGCACATATTGA	0.438000													4	107					0	0	1	0	0
AMOTL1	154810	broad.mit.edu	37	11	94599237	94599237	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:94599237G>C	ENST00000433060.2	+	11	2533	c.2392G>C	c.(2392-2394)Gca>Cca	p.A798P	AMOTL1_ENST00000317829.8_Missense_Mutation_p.A748P|AMOTL1_ENST00000317837.9_Intron	NM_130847.2	NP_570899.1	Q8IY63	AMOL1_HUMAN	angiomotin like 1	798						cytoplasm|tight junction	identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	36		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				TCCATCCATAGCAGCAGCTAC	0.552000													6	82					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126312058	126312058	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr10:126312058G>A	ENST00000337318.3	-	5	1233	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	FAM53B_ENST00000392754.3_Missense_Mutation_p.S341L|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	341										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GCCGGAGGCTGAGAGCAGGGC	0.716000													5	10					0	0	1	0	0
DUS4L	11062	broad.mit.edu	37	7	107211589	107211589	+	Splice_Site	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:107211589G>A	ENST00000265720.3	+	4	478		c.e4-1		DUS4L_ENST00000402620.1_Splice_Site	NM_001270419.1|NM_181581.2	NP_001257348.1|NP_853559.1	O95620	DUS4L_HUMAN	dihydrouridine synthase 4-like (S. cerevisiae)						tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8						TATGCTCACAGGTTGGCTTTT	0.338000													15	62					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111145581	111145581	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr13:111145581C>T	ENST00000360467.5	+	39	3892	c.3586C>T	c.(3586-3588)Cgc>Tgc	p.R1196C		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1196	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCGTGGGATCCGCGGCTTACA	0.607000													5	109					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839350	62839350	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr20:62839350G>A	ENST00000536311.1	+	7	1165	c.801G>A	c.(799-801)gaG>gaA	p.E267E	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Silent_p.E267E			Q01538	MYT1_HUMAN	myelin transcription factor 1	267	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaggaggaggaagaggagg	0.577000													3	27					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640152	99640152	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr12:99640152C>G	ENST00000547776.2	-	13	2246	c.2247G>C	c.(2245-2247)gaG>gaC	p.E749D	ANKS1B_ENST00000329257.7_Missense_Mutation_p.E749D|ANKS1B_ENST00000547010.1_Missense_Mutation_p.E329D	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	749						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTGATGTTTTCTCATTGGAAG	0.408000													13	37					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220309638	220309638	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:220309638C>T	ENST00000312358.7	+	3	702	c.570C>T	c.(568-570)agC>agT	p.S190S	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000396698.1_Silent_p.S86S	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	190					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGTGGGGCAGCGGGCAGACGG	0.706000													19	78					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597294	36597294	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:36597294G>C	ENST00000299440.5	+	2	2552	c.2440G>C	c.(2440-2442)Gag>Cag	p.E814Q		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	814					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				CTTCCAGCTAGAGATAGGGGA	0.473000									Familial Hemophagocytic Lymphohistiocytosis				27	79					0	0	1	0	0
CAP1	10487	broad.mit.edu	37	1	40537170	40537170	+	Missense_Mutation	SNP	A	A	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:40537170A>C	ENST00000372797.3	+	13	1954	c.1393A>C	c.(1393-1395)Aag>Cag	p.K465Q	CAP1_ENST00000479759.1_3'UTR|CAP1_ENST00000372802.1_Missense_Mutation_p.K464Q|CAP1_ENST00000372792.2_Missense_Mutation_p.K465Q|CAP1_ENST00000372798.1_Missense_Mutation_p.K464Q|CAP1_ENST00000372805.3_Missense_Mutation_p.K465Q|CAP1_ENST00000340450.3_Missense_Mutation_p.K464Q	NM_001105530.1|NM_006367.3	NP_001099000.1|NP_006358.1	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	465					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAACGGGCAGAAGTTGGTCAC	0.463000													14	38					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97922852	97922852	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr7:97922852G>C	ENST00000005260.8	-	14	1732	c.1517C>G	c.(1516-1518)tCg>tGg	p.S506W		NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	506	Binds F-actin.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			GATGGGTGCCGAGCGATCATT	0.562000													30	138					0	0	1	0	0
COG8	84342	broad.mit.edu	37	16	69370549	69370549	+	Silent	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:69370549C>T	ENST00000306875.4	-	2	558	c.444G>A	c.(442-444)cgG>cgA	p.R148R	RP11-343C2.7_ENST00000564737.1_3'UTR|RP11-343C2.9_ENST00000563634.1_Silent_p.R23R|COG8_ENST00000562081.1_Silent_p.R148R	NM_032382.4	NP_115758.3	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	148					protein transport	Golgi membrane|Golgi transport complex				breast(3)|kidney(1)|large_intestine(2)|ovary(2)|skin(1)	9						TTTCTGTGTGCCGGTTTAGGG	0.478000													4	114					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543326	23543326	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:23543326T>C	ENST00000300619.7	-	4	2660	c.2455A>G	c.(2455-2457)Att>Gtt	p.I819V	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.I787V	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	819						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CCAGTATGAATTGTCTTATGC	0.398000													28	102					0	0	1	0	0
S100A10	6281	broad.mit.edu	37	1	151955683	151955683	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:151955683T>A	ENST00000368811.3	-	3	909	c.250A>T	c.(250-252)Aat>Tat	p.N84Y	S100A10_ENST00000368809.1_Missense_Mutation_p.N84Y	NM_002966.2	NP_002957.1	P60903	S10AA_HUMAN	S100 calcium binding protein A10	84					signal transduction		calcium ion binding|receptor binding			breast(1)|kidney(1)|lung(2)|ovary(2)	6	Melanoma(130;0.0648)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			AAATAGTCATTGCATGCAATG	0.473000													49	167					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6635087	6635087	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr1:6635087G>A	ENST00000333172.6	+	3	1088	c.895G>A	c.(895-897)Gcc>Acc	p.A299T	TAS1R1_ENST00000351136.3_Intron|TAS1R1_ENST00000328191.4_Missense_Mutation_p.A299T	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	299					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GGTGTGGGTCGCCTCAGAAGC	0.647000													15	45					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48139103	48139103	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:48139103T>A	ENST00000311303.3	-	19	2965	c.2620A>T	c.(2620-2622)Acc>Tcc	p.T874S	ABCC12_ENST00000448542.1_Missense_Mutation_p.T871S|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	874	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GTGGTCTTGGTGAAGACGAAG	0.527000													33	129					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599100	29599100	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr13:29599100C>T	ENST00000431530.3	+	1	353	c.295C>T	c.(295-297)Cag>Tag	p.Q99*		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	89						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GAAAGGCTCTCAGGCTGGCTC	0.463000													7	25					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3225217	3225217	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr9:3225217G>C	ENST00000382004.3	-	18	2386	c.2075C>G	c.(2074-2076)gCc>gGc	p.A692G		NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	692					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CTCTCTTTTGGCTTGAGGCTC	0.468000													80	40					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126603	32126603	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr5:32126603G>A	ENST00000265070.6	-	4	927	c.612C>T	c.(610-612)ctC>ctT	p.L204L		NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	204					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						TGTTATTGGTGAGGGGATGTG	0.458000													46	171					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49631663	49631663	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:49631663G>A	ENST00000334186.4	+	3	629	c.280G>A	c.(280-282)Gag>Aag	p.E94K	PPFIA3_ENST00000602351.1_Missense_Mutation_p.E94K	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	94						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CTTATGTCGGGAGCAGCTGCT	0.582000													15	82					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33671366	33671366	+	Silent	SNP	G	G	A			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr21:33671366G>A	ENST00000399784.2	+	3	271	c.84G>A	c.(82-84)gaG>gaA	p.E28E	MRAP_ENST00000399786.3_Silent_p.E28E|MRAP_ENST00000497833.1_Intron|MRAP_ENST00000303645.5_Silent_p.E28E|MRAP_ENST00000339944.4_Silent_p.E28E	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	28					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						CCGTGGACGAGAAGAAGCTGA	0.577000													5	38					0	0	1	0	0
RFPL3	10738	broad.mit.edu	37	22	32754256	32754256	+	Silent	SNP	G	G	A	rs61729170	byFrequency	TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr22:32754256G>A	ENST00000249007.4	+	1	403	c.198G>A	c.(196-198)tcG>tcA	p.S66S	RFPL3_ENST00000397468.1_Silent_p.S37S|RFPL3_ENST00000382088.3_Silent_p.S37S	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	66							zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						GCATCAATTCGCTGCAGAAGG	0.537000													4	134					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24469021	24469023	+	In_Frame_Del	DEL	GTC	GTC	-			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:24469021_24469023delGTC	ENST00000355123.4	-	29	3995_3997	c.3552_3554delGAC	c.(3550-3555)aca>ac	p.TT1184del	ITSN2_ENST00000406921.3_In_Frame_Del_p.TT1184del|ITSN2_ENST00000361999.3_In_Frame_Del_p.TT1157del	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1184	SH3 5.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCTGAGTCTGTCGTCATCTTAA	0.384													37	138	---	---	---	---					
IGKV1D-8	28904	broad.mit.edu	37	2	90259860	90259861	+	RNA	INS	-	-	C			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr2:90259860_90259861insC	ENST00000471857.1	+	0	236																											AATTTACTCAGCCAATGTGCTC	0.480													7	251	---	---	---	---					
C11orf70	85016	broad.mit.edu	37	11	101937227	101937227	+	Frame_Shift_Del	DEL	A	A	-			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr11:101937227delA	ENST00000434758.2	+	4	308	c.280delA	c.(280-282)aafs	p.K95fs	C11orf70_ENST00000526781.1_Frame_Shift_Del_p.K95fs|C11orf70_ENST00000534360.1_Intron	NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	95										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		AACTGAAGTGAAAAAAATTGA	0.284													7	1431	---	---	---	---					
TAF1C	9013	broad.mit.edu	37	16	84212717	84212717	+	Frame_Shift_Del	DEL	T	T	-			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr16:84212717delT	ENST00000567759.1	-	14	2622	c.2440delA	c.(2440-2442)tgfs	p.M814fs	TAF1C_ENST00000341690.6_Frame_Shift_Del_p.M720fs|TAF1C_ENST00000541676.1_Frame_Shift_Del_p.M721fs|TAF1C_ENST00000566732.1_Frame_Shift_Del_p.M788fs|TAF1C_ENST00000570117.1_Frame_Shift_Del_p.M482fs|TAF1C_ENST00000378541.4_Frame_Shift_Del_p.M814fs	NM_005679.3	NP_005670.3	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	814					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						TCACGGAGCATCTGCCGCTGC	0.692													11	26	---	---	---	---					
LONP1	9361	broad.mit.edu	37	19	5692088	5692089	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:5692088_5692089insAA	ENST00000360614.3	-	18	2991_2992	c.2834_2835insTT	c.(2833-2835)agcfs	p.S945fs	LONP1_ENST00000593119.1_Frame_Shift_Ins_p.S881fs|LONP1_ENST00000585374.1_Frame_Shift_Ins_p.S831fs|LONP1_ENST00000590729.1_Frame_Shift_Ins_p.S815fs|LONP1_ENST00000540670.2_Frame_Shift_Ins_p.S749fs	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	945					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCGGGAAGGCGATGTCGAAGAT	0.649													29	149	---	---	---	---					
C19orf43	79002	broad.mit.edu	37	19	12845461	12845461	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UF-A7JV-01A-11D-A34J-08	TCGA-UF-A7JV-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c824fe0-b5bb-4b9b-8104-2917473db2d5	058b3a27-6dcc-4456-9bcf-8bf795340434	g.chr19:12845461delC	ENST00000242784.4	-	1	128	c.11delG	c.(10-12)cafs	p.R4fs	C19orf43_ENST00000588213.1_Frame_Shift_Del_p.R4fs|C19orf43_ENST00000592273.1_Frame_Shift_Del_p.R4fs	NM_024038.2	NP_076943.1	Q9BQ61	CS043_HUMAN	chromosome 19 open reading frame 43	4										endometrium(2)|large_intestine(2)	4						CCGTCTCCCTCGGGCAGCCAT	0.751													2	4	---	---	---	---