Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPM1L	151742	broad.mit.edu	37	3	160786652	160786652	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:160786652T>G	ENST00000498165.1	+	4	891	c.790T>G	c.(790-792)Tct>Gct	p.S264A	PPM1L_ENST00000480117.1_3'UTR|PPM1L_ENST00000295839.9_Missense_Mutation_p.S137A|PPM1L_ENST00000464260.1_Missense_Mutation_p.S85A	NM_139245.2	NP_640338.2	Q5SGD2	PPM1L_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1L	264	PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CCTGGCCATGTCTCGGTCCCT	0.512000													16	114					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134006320	134006320	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:134006320C>T	ENST00000338492.4	+	3	451	c.287C>T	c.(286-288)gCg>gTg	p.A96V	DPYSL4_ENST00000368629.1_Missense_Mutation_p.A19V|DPYSL4_ENST00000368627.1_Missense_Mutation_p.A19V|DPYSL4_ENST00000493882.1_3'UTR	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	96					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ACCAAGGCAGCGCTAGCAGGA	0.617000													11	80					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138782	126138782	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:126138782G>A	ENST00000299308.3	+	9	2771	c.2763G>A	c.(2761-2763)gcG>gcA	p.A921A	TMEM132B_ENST00000535886.1_Silent_p.A433A	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	921						integral to membrane		p.A921A(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACTGCGTGGCGTTTGCCTGGA	0.522000													31	111					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86887360	86887360	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:86887360C>G	ENST00000373119.4	+	7	1620	c.1475C>G	c.(1474-1476)aCa>aGa	p.T492R	KLHL4_ENST00000373114.4_Missense_Mutation_p.T492R	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	492						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						ACTTTGAATACAGTGGAATGT	0.418000													35	14					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76714147	76714147	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:76714147A>G	ENST00000264917.5	+	18	2050	c.2005A>G	c.(2005-2007)Aat>Gat	p.N669D	PDE8B_ENST00000333194.4_Missense_Mutation_p.N614D|PDE8B_ENST00000505283.1_Missense_Mutation_p.N134D|PDE8B_ENST00000340978.3_Missense_Mutation_p.N622D|PDE8B_ENST00000346042.3_Missense_Mutation_p.N572D|PDE8B_ENST00000342343.4_Missense_Mutation_p.N649D	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	669	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TTTCCTCTGCAATGCAGGCAG	0.567000													21	45					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423919	190423919	+	Silent	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:190423919A>T	ENST00000367462.3	-	2	333	c.102T>A	c.(100-102)gcT>gcA	p.A34A	FAM5C_ENST00000534846.1_5'UTR|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		34						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GATCCGAAACAGCAGCAACCG	0.512000													14	46					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124322817	124322817	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:124322817G>A	ENST00000394339.2	+	2	411	c.71G>A	c.(70-72)cGt>cAt	p.R24H	SPRY1_ENST00000339241.1_Missense_Mutation_p.R24H	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	24					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						TTGGATAGCCGTCAGAGATTA	0.463000													5	218					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32135922	32135922	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:32135922C>T	ENST00000312561.4	+	4	2447	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ACCTGTCTTTCCCTGTGGAAA	0.423000													15	48					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976878	46976878	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:46976878C>G	ENST00000371253.2	-	11	2508	c.2293G>C	c.(2293-2295)Gtt>Ctt	p.V765L	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000283297.5_Missense_Mutation_p.V568L	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	765					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						TTTGTGAGAACTAGCAGCACC	0.542000													21	36					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94690472	94690472	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:94690472C>T	ENST00000282020.4	+	15	2730	c.2472C>T	c.(2470-2472)ggC>ggT	p.G824G	GRID2_ENST00000510992.1_Silent_p.G729G	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	824					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGAAAGGAGGCGCCCTGGACA	0.512000													11	70					0	0	1	0	0
PINX1	54984	broad.mit.edu	37	8	10623050	10623050	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:10623050G>A	ENST00000314787.3	-	7	967	c.848C>T	c.(847-849)cCg>cTg	p.P283L	PINX1_ENST00000426190.2_3'UTR|CTD-2135J3.3_ENST00000519568.1_RNA|PINX1_ENST00000519088.1_3'UTR|SOX7_ENST00000554914.1_Intron|SOX7_ENST00000553390.1_Intron	NM_017884.4	NP_060354.4			PIN2/TERF1 interacting, telomerase inhibitor 1											kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		GCCCTCAGGCGGCTGCACATG	0.572000													6	27					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53621287	53621287	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:53621287C>A	ENST00000425354.2	-	3	530	c.43G>T	c.(43-45)Ggg>Tgg	p.G15W	RARG_ENST00000394426.1_Missense_Mutation_p.G15W|RARG_ENST00000327550.3_Intron|RARG_ENST00000543762.1_Intron	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	15	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GATCCAGGCCCCAGGGCACCA	0.667000													7	18					0.27861	0.27861	1	1	0
HIST1H3I	8354	broad.mit.edu	37	6	27839778	27839778	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:27839778C>T	ENST00000328488.2	-	1	321	c.316G>A	c.(316-318)Gag>Aag	p.E106K		NM_003533.2	NP_003524.1	P68431	H31_HUMAN	histone cluster 1, H3i	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TTGGTATCCTCAAATAGCCCC	0.572000													45	90					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628328	51628328	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:51628328G>A	ENST00000440804.3	+	1	164	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	SIGLEC9_ENST00000250360.3_Missense_Mutation_p.E33K	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	33	Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GACGGTGCAGGAAGGCCTGTG	0.607000													26	40					0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43664472	43664472	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr18:43664472G>C	ENST00000593152.2	-	11	1967	c.1428C>G	c.(1426-1428)atC>atG	p.I476M	ATP5A1_ENST00000398752.6_Missense_Mutation_p.I526M|ATP5A1_ENST00000282050.2_Missense_Mutation_p.I526M|ATP5A1_ENST00000590665.1_Missense_Mutation_p.I504M	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	526					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						ATTCATACCTGATAGTGCCCA	0.358000													14	51					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48874749	48874749	+	Silent	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:48874749C>G	ENST00000262105.2	+	3	581	c.372C>G	c.(370-372)ggC>ggG	p.G124G	MCM4_ENST00000523944.1_Silent_p.G124G	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	124					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CACAGAAGGGCCTGCAAGTGG	0.547000													17	48					0	0	1	0	0
SULT2B1	6820	broad.mit.edu	37	19	49094970	49094970	+	Silent	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:49094970G>C	ENST00000323090.4	+	3	858	c.483G>C	c.(481-483)ctG>ctC	p.L161L	SULT2B1_ENST00000594274.1_3'UTR|SULT2B1_ENST00000201586.2_Silent_p.L176L	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	176					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		ACCAGTTCCTGAGGGACTTCC	0.632000													3	17					0	0	1	0	0
EPN1	29924	broad.mit.edu	37	19	56206141	56206141	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:56206141G>A	ENST00000411543.2	+	10	2119	c.1572G>A	c.(1570-1572)gcG>gcA	p.A524A	EPN1_ENST00000085079.7_Silent_p.A412A|EPN1_ENST00000270460.6_Silent_p.A438A	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	438	3 X 3 AA repeats of N-P-F.|Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GCCCTGGGGCGTTTGACATGA	0.687000													7	28					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588477	247588477	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:247588477C>T	ENST00000366497.2	+	4	2512	c.1732C>T	c.(1732-1734)Cgt>Tgt	p.R578C	NLRP3_ENST00000348069.2_Missense_Mutation_p.R578C|NLRP3_ENST00000366496.2_Missense_Mutation_p.R578C|NLRP3_ENST00000336119.3_Missense_Mutation_p.R578C|NLRP3_ENST00000391827.2_Missense_Mutation_p.R578C|NLRP3_ENST00000391828.3_Missense_Mutation_p.R578C|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	578					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TTTTGTTGTACGTTTCCTCTT	0.463000													21	79					0	0	1	0	0
OGFRL1	79627	broad.mit.edu	37	6	72006455	72006455	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:72006455G>A	ENST00000370435.4	+	6	761	c.627G>A	c.(625-627)ctG>ctA	p.L209L	RP11-154D6.1_ENST00000432050.1_RNA|RP11-154D6.1_ENST00000587253.1_RNA|RP11-154D6.1_ENST00000588612.1_RNA|RP11-154D6.1_ENST00000423255.1_RNA|RP11-154D6.1_ENST00000586030.1_RNA|RP11-154D6.1_ENST00000412751.1_RNA|RP11-154D6.1_ENST00000591156.1_RNA|RP11-154D6.1_ENST00000586232.1_RNA|RP3-331H24.5_ENST00000602823.1_lincRNA	NM_024576.3	NP_078852.3	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	209						membrane	receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|upper_aerodigestive_tract(1)	13						GAATAAAACTGACTGATAAAA	0.348000													30	45					0	0	1	0	0
TOLLIP	54472	broad.mit.edu	37	11	1298422	1298422	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:1298422G>A	ENST00000527886.1	-	6	845	c.465C>T	c.(463-465)aaC>aaT	p.N155N	TOLLIP_ENST00000263646.7_Silent_p.N196N|TOLLIP_ENST00000317204.6_Silent_p.N224N|TOLLIP_ENST00000542915.1_Silent_p.N174N|TOLLIP_ENST00000525159.1_Silent_p.N163N|TOLLIP_ENST00000527938.1_3'UTR			Q9H0E2	TOLIP_HUMAN	toll interacting protein	224					cell-cell signaling|inflammatory response|innate immune response|intracellular signal transduction|leukocyte activation|phosphorylation	cytosol|interleukin-1 receptor complex|interleukin-18 receptor complex	kinase binding|signal transducer activity|Toll-like receptor binding			large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	6		all_cancers(49;7.62e-05)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00152)|Lung(200;0.09)|LUSC - Lung squamous cell carcinoma(625;0.107)		GGGGCTGGGCGTTCACGGCGG	0.632000													23	47					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41174333	41174333	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:41174333C>G	ENST00000355653.3	-	1	102	c.7G>C	c.(7-9)Gac>Cac	p.D3H	VAT1_ENST00000587173.1_Missense_Mutation_p.D3H	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	3						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TCTCTCTCGTCGGACATGGCT	0.692000													34	10					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815027	67815027	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:67815027C>T	ENST00000265686.3	+	11	1401	c.1293C>T	c.(1291-1293)gcC>gcT	p.A431A	TCIRG1_ENST00000532635.1_Silent_p.A215A	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	431					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						CTGTGAAGGCCGCGCAGAACG	0.652000													19	37					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184073265	184073265	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:184073265C>T	ENST00000265593.4	-	12	1394	c.1223G>A	c.(1222-1224)cGc>cAc	p.R408H	CLCN2_ENST00000434054.2_Missense_Mutation_p.R364H|CLCN2_ENST00000423355.2_Missense_Mutation_p.R49H|CLCN2_ENST00000475279.1_5'UTR|CLCN2_ENST00000344937.7_Missense_Mutation_p.R408H|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000457512.1_Missense_Mutation_p.R408H	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	408						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CAGGCCCTGGCGGACCCACGT	0.587000													25	161					0	0	1	0	0
ZNF747	65988	broad.mit.edu	37	16	30544131	30544131	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:30544131G>A	ENST00000535210.1	-	3	854	c.682C>T	c.(682-684)Cgg>Tgg	p.R228W	ZNF747_ENST00000395094.3_3'UTR|ZNF747_ENST00000252799.3_3'UTR|ZNF747_ENST00000568028.1_Missense_Mutation_p.R228W|ZNF747_ENST00000569360.1_Missense_Mutation_p.R228W			Q9BV97	ZN747_HUMAN	zinc finger protein 747	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						TGGATGGCCCGGTGTTTGCTC	0.662000													8	9					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55133835	55133835	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:55133835C>A	ENST00000257290.5	+	7	1379	c.1048C>A	c.(1048-1050)Ctg>Atg	p.L350M	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	350	Ig-like C2-type 4.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GATATCCTGGCTGAAAAACAA	0.448000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			18	62					2.35188e-11	2.64052e-11	1	1	0
GOLGA8IP	283796	broad.mit.edu	37	15	23261901	23261901	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:23261901G>T	ENST00000450802.3	+	12	1111	c.1013G>T	c.(1012-1014)gGa>gTa	p.G338V																								CTGAACCGGGGACAAGAAGAG	0.572000													23	44					2.21704e-12	2.52354e-12	1	1	0
AKAP7	9465	broad.mit.edu	37	6	131540889	131540889	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:131540889C>T	ENST00000431975.2	+	7	889	c.791C>T	c.(790-792)tCc>tTc	p.S264F	AKAP7_ENST00000541650.1_Missense_Mutation_p.S263F|AKAP7_ENST00000537868.1_5'UTR|AKAP7_ENST00000263050.3_5'UTR|AKAP7_ENST00000368123.4_Missense_Mutation_p.S242F	NM_016377.3	NP_057461.2	O43687	AKA7A_HUMAN	A kinase (PRKA) anchor protein 7	0					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|stomach(1)	13	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		GATCTTTGCTCCATGCTGAAG	0.274000													16	51					0	0	1	0	0
EPN2	22905	broad.mit.edu	37	17	19232091	19232091	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:19232091C>T	ENST00000314728.5	+	8	1699	c.1215C>T	c.(1213-1215)ccC>ccT	p.P405P	EPN2_ENST00000395620.2_Silent_p.P348P|EPN2_ENST00000347697.2_Silent_p.P348P|EPN2_ENST00000395618.3_Silent_p.P120P|EPN2_ENST00000571254.1_Silent_p.P341P|EPN2_ENST00000395626.1_Silent_p.P405P|EPN2_ENST00000575595.1_Silent_p.P113P	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	405	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					AATCTGTCCCCAAGAACTCGG	0.622000													49	33					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160309984	160309984	+	Silent	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:160309984A>G	ENST00000241704.7	-	2	370	c.141T>C	c.(139-141)ttT>ttC	p.F47F	COPA_ENST00000368069.3_Silent_p.F47F	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	47					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATGTTCATCAAACTTGTCAA	0.403000													19	84					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38481992	38481992	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:38481992C>T	ENST00000263409.4	-	20	3161	c.2999G>A	c.(2998-3000)gGc>gAc	p.G1000D	LIFR_ENST00000453190.2_Missense_Mutation_p.G1000D	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	1000					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TGGCTTATAGCCTGCCCCTCC	0.458000			T	PLAG1	salivary adenoma								4	95					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807583	22807583	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr18:22807583C>T	ENST00000361524.3	-	4	447	c.299G>A	c.(298-300)aGc>aAc	p.S100N	ZNF521_ENST00000579111.1_5'UTR|ZNF521_ENST00000538137.2_Missense_Mutation_p.S100N|ZNF521_ENST00000584787.1_5'UTR	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	100					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTCTCCATGGCTAGGGGAAGT	0.507000			T	PAX5	ALL								19	55					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69684939	69684939	+	Silent	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:69684939T>C	ENST00000395198.3	-	25	3115	c.2868A>G	c.(2866-2868)acA>acG	p.T956T	HERC4_ENST00000412272.2_Silent_p.T878T|HERC4_ENST00000395187.2_3'UTR|HERC4_ENST00000373700.4_Silent_p.T948T|HERC4_ENST00000277817.6_Silent_p.T846T	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	956	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						CTTTGTATTCTGTATTCTAAA	0.328000													22	48					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135291531	135291531	+	Missense_Mutation	SNP	C	C	T	rs112867264		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:135291531C>T	ENST00000285968.6	+	21	2964	c.2938C>T	c.(2938-2940)Cgt>Tgt	p.R980C		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	980					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AGTTGCAATTCGTCATGAAAC	0.333000													4	109					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885472	88885472	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:88885472C>T	ENST00000319675.3	-	1	824	c.728G>A	c.(727-729)tGt>tAt	p.C243Y		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	243										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CCCAGAGCGACAGCCATTAAA	0.522000													84	97					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562941	140562941	+	Silent	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:140562941A>G	ENST00000361016.2	+	1	1962	c.807A>G	c.(805-807)ttA>ttG	p.L269L		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		269	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGGGATTTAGACGGCGGAG	0.483000													4	103					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102502959	102502959	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr14:102502959G>A	ENST00000360184.4	+	57	11052	c.10888G>A	c.(10888-10890)Ggt>Agt	p.G3630S	RP11-1017G21.4_ENST00000557551.1_RNA|DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3630	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						ACTGAGATTCGGTAACCCCCT	0.438000													40	88					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169506008	169506008	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:169506008C>T	ENST00000256935.8	+	49	5104	c.5024C>T	c.(5023-5025)aCg>aTg	p.T1675M	DOCK2_ENST00000540750.1_Missense_Mutation_p.T736M|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.T1167M	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1675					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCACCCAAGACGCCGAGAGTG	0.557000													18	91					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21607770	21607770	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:21607770A>G	ENST00000392288.2	+	4	2418	c.2309A>G	c.(2308-2310)gAg>gGg	p.E770G	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.E642G	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	642					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CATACTGAAGAGACTGTACAA	0.388000													11	89					0	0	1	0	0
CCDC6	8030	broad.mit.edu	37	10	61665982	61665982	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:61665982C>A	ENST00000263102.6	-	1	432	c.201G>T	c.(199-201)caG>caT	p.Q67H		NM_005436.4	NP_005427.2	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	67						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton		CCDC6/RET(4)	breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|stomach(1)	18				Kidney(211;0.0597)		TGTTCTCTTGCTGCAGCGAGG	0.647000			T	RET	NSCLC								40	96					1.02687e-29	1.21357e-29	1	1	0
ANKS1B	56899	broad.mit.edu	37	12	99640465	99640465	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:99640465G>T	ENST00000547776.2	-	13	1933	c.1934C>A	c.(1933-1935)cCt>cAt	p.P645H	ANKS1B_ENST00000547010.1_Missense_Mutation_p.P225H|ANKS1B_ENST00000550833.1_5'UTR|ANKS1B_ENST00000329257.7_Missense_Mutation_p.P645H	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	645						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GAAAGGCAAAGGACTGTTTGC	0.383000													21	51					6.33239e-15	7.27488e-15	1	1	0
BOC	91653	broad.mit.edu	37	3	112991400	112991400	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:112991400G>A	ENST00000495514.1	+	7	1515	c.811G>A	c.(811-813)Gtc>Atc	p.V271I	BOC_ENST00000355385.3_Missense_Mutation_p.V271I|BOC_ENST00000273395.4_Missense_Mutation_p.V271I			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	271	Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			TGGGTCCAGTGTCACCGGCTA	0.602000													97	248					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296329	39296329	+	Silent	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:39296329T>G	ENST00000345847.4	-	1	410	c.411A>C	c.(409-411)ccA>ccC	p.P137P		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	133	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ggcagcagGTTGGCTGGCAGC	0.682000													4	31					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367299	107367299	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr9:107367299T>C	ENST00000542196.1	-	1	652	c.610A>G	c.(610-612)Aca>Gca	p.T204A		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ATGAACAATGTTGTGGCCACA	0.398000													5	202					0	0	1	0	0
TK1	7083	broad.mit.edu	37	17	76170975	76170975	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:76170975G>A	ENST00000588734.1	-	6	907	c.669C>T	c.(667-669)ttC>ttT	p.F223F	TK1_ENST00000590430.1_3'UTR|TK1_ENST00000405273.1_Silent_p.F190F|TK1_ENST00000590862.1_Intron|TK1_ENST00000301634.7_Silent_p.F190F			P04183	KITH_HUMAN	thymidine kinase 1, soluble	190					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			AGGCCTTCTTGAAGTAGCAGA	0.632000													19	13					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983223	97983223	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:97983223G>A	ENST00000383696.2	+	1	136	c.95G>A	c.(94-96)gGa>gAa	p.G32E	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GTTCTCACAGGATTTTTACAT	0.398000													219	215					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172486831	172486831	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:172486831C>T	ENST00000417960.1	+	13	1707	c.1230C>T	c.(1228-1230)agC>agT	p.S410S	ECT2_ENST00000232458.5_Silent_p.S411S|ECT2_ENST00000540509.1_Silent_p.S442S|ECT2_ENST00000441497.2_Silent_p.S411S|ECT2_ENST00000427830.1_Silent_p.S411S|ECT2_ENST00000392692.3_Silent_p.S442S	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	411					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CTTCTAAAAGCTCCACTCCAG	0.348000													42	89					0	0	1	0	0
NFU1	27247	broad.mit.edu	37	2	69627580	69627580	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:69627580G>A	ENST00000410022.2	-	7	841	c.636C>T	c.(634-636)agC>agT	p.S212S	NFU1_ENST00000471185.1_Intron|NFU1_ENST00000394305.1_Silent_p.S71S|NFU1_ENST00000303698.3_Silent_p.S188S|NFU1_ENST00000462320.1_Silent_p.S71S	NM_001002755.2	NP_001002755.1	Q9UMS0	NFU1_HUMAN	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	212	NifU.				iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	7						AACTAGGGCAGCTGGTACAAG	0.438000													57	206					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175348837	175348837	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:175348837C>T	ENST00000367674.1	-	9	2522	c.1814G>A	c.(1813-1815)cGc>cAc	p.R605H	TNR_ENST00000263525.2_Missense_Mutation_p.R605H	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	605	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GGTTGCTGTGCGAGAACCAAC	0.478000													19	57					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155764443	155764443	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:155764443G>A	ENST00000159060.2	-	5	552	c.450C>T	c.(448-450)aaC>aaT	p.N150N		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	150	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GGTAGCTCTCGTTAGGGGTGT	0.562000													9	39					0	0	1	0	0
OR6B3	150681	broad.mit.edu	37	2	240984708	240984708	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:240984708C>A	ENST00000319423.4	-	1	781	c.782G>T	c.(781-783)cGg>cTg	p.R261L		NM_173351.1	NP_775486.1	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B, member 3	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		GGCCTGGGGCCGGACATACAT	0.542000													42	61					4.00102e-26	4.70596e-26	1	1	0
TRAFD1	10906	broad.mit.edu	37	12	112578678	112578678	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:112578678C>T	ENST00000257604.5	+	5	910	c.293C>T	c.(292-294)tCc>tTc	p.S98F	TRAFD1_ENST00000412615.2_Missense_Mutation_p.S98F	NM_001143906.1	NP_001137378.1	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	98					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding			kidney(5)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	17						TTAGAACTTTCCATTCTCAAA	0.458000													32	120					0	0	1	0	0
RBM11	54033	broad.mit.edu	37	21	15599512	15599512	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr21:15599512G>C	ENST00000400577.3	+	5	753	c.744G>C	c.(742-744)aaG>aaC	p.K248N	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	248							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		ATAAACGAAAGAGACAAAAGC	0.403000													48	203					0	0	1	0	0
KRTAP4-1	85285	broad.mit.edu	37	17	39341000	39341000	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:39341000C>A	ENST00000398472.1	-	1	594	c.107G>T	c.(106-108)tGc>tTc	p.C36F				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	36	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament				kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGCTGGGGCAGCAACAGGT	0.617000													15	46					6.72482e-11	7.41532e-11	1	1	0
SI	6476	broad.mit.edu	37	3	164737395	164737395	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:164737395G>A	ENST00000264382.3	-	28	3480	c.3418C>T	c.(3418-3420)Cct>Tct	p.P1140S		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1140	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCTACACCAGGGGGTTGGTCT	0.443000										HNSCC(35;0.089)			30	97					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2473414	2473414	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:2473414G>T	ENST00000258711.6	+	2	1275	c.1140G>T	c.(1138-1140)tgG>tgT	p.W380C		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	380				W -> C (in Ref. 1; AAF81692).	dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		AGGAGGACTGGTTCGCCAAGA	0.642000													31	16					1.16021e-09	1.2514e-09	1	1	0
UBR2	23304	broad.mit.edu	37	6	42600362	42600362	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:42600362C>G	ENST00000372899.1	+	12	1612	c.1354C>G	c.(1354-1356)Cga>Gga	p.R452G	UBR2_ENST00000372883.3_5'UTR|UBR2_ENST00000372901.1_Missense_Mutation_p.R452G	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	452					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TTTGAGACATCGAGATGCCCA	0.363000													19	43					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70539521	70539521	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:70539521A>G	ENST00000260128.4	+	16	2644	c.1927A>G	c.(1927-1929)Aag>Gag	p.K643E	SULF1_ENST00000458141.2_Missense_Mutation_p.K643E|SULF1_ENST00000419716.3_Missense_Mutation_p.K643E|SULF1_ENST00000402687.4_Missense_Mutation_p.K643E|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	643					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GAAGGACCATAAGGCATACAT	0.463000													15	29					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21240550	21240550	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:21240550A>T	ENST00000261560.5	+	5	1617	c.1436A>T	c.(1435-1437)cAt>cTt	p.H479L		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						AAGGTAATTCATTCTGGAGAG	0.368000													28	76					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95669937	95669937	+	Silent	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr14:95669937A>G	ENST00000298912.4	-	9	1862	c.1749T>C	c.(1747-1749)gtT>gtC	p.V583V		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	583						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		GAGGTGAAGGAACTTTGTTGA	0.398000													45	100					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89804494	89804494	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:89804494G>A	ENST00000289816.5	+	11	1772	c.1460G>A	c.(1459-1461)cGg>cAg	p.R487Q	FANCA_ENST00000389301.3_3'UTR|ZNF276_ENST00000443381.2_Missense_Mutation_p.R562Q|ZNF276_ENST00000446326.2_Missense_Mutation_p.R348Q|ZNF276_ENST00000568064.1_3'UTR	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TGTGGCCGGCGGTTTGAGAAG	0.597000													18	22					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96803345	96803345	+	Silent	SNP	G	G	A	rs142516442	byFrequency	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:96803345G>A	ENST00000342380.2	-	2	149	c.150C>T	c.(148-150)tcC>tcT	p.S50S		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	50					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						CCTTGTCCCCGGAGGCCTGGG	0.602000													60	102					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113529452	113529452	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:113529452A>G	ENST00000297405.5	-	28	4811	c.4567T>C	c.(4567-4569)Tct>Cct	p.S1523P	CSMD3_ENST00000455883.2_Missense_Mutation_p.S1419P|CSMD3_ENST00000343508.3_Missense_Mutation_p.S1483P|CSMD3_ENST00000352409.3_Missense_Mutation_p.S1523P	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1523	CUB 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTGGCAACAGAACCTATCAAA	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	68					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135865147	135865147	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr9:135865147C>T	ENST00000339463.3	+	10	1486	c.667C>T	c.(667-669)Cgc>Tgc	p.R223C	GFI1B_ENST00000372124.1_Missense_Mutation_p.R177C|GFI1B_ENST00000372122.1_Missense_Mutation_p.R223C|GFI1B_ENST00000450530.1_Missense_Mutation_p.R223C|GFI1B_ENST00000372123.1_Missense_Mutation_p.R177C|GFI1B_ENST00000534944.1_Missense_Mutation_p.R177C			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	223	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding	p.R223F(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CTTCGAGTGCCGCATGTGCGG	0.682000													5	39					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	132092430	132092430	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:132092430G>A	ENST00000370836.2	-	2	616	c.201C>T	c.(199-201)ctC>ctT	p.L67L	HS6ST2_ENST00000521489.1_Silent_p.L67L	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	67						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					GCTTGTCCAGGAGCGGCCGGG	0.721000													3	11					0	0	1	0	0
DLX1	1745	broad.mit.edu	37	2	172950420	172950420	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:172950420C>T	ENST00000361725.4	+	1	467	c.15C>T	c.(13-15)acC>acT	p.T5T	DLX1_ENST00000341900.6_Silent_p.T5T	NM_178120.4	NP_835221.2	P56177	DLX1_HUMAN	distal-less homeobox 1	5						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|lung(4)|prostate(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CCATGACCACCATGCCAGAAA	0.572000													4	78					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72290045	72290045	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:72290045C>T	ENST00000334456.5	-	28	2610	c.2365G>A	c.(2365-2367)Gac>Aac	p.D789N	PDE2A_ENST00000444035.2_Missense_Mutation_p.D780N|PDE2A_ENST00000418754.2_Missense_Mutation_p.D674N|PDE2A_ENST00000376450.3_Missense_Mutation_p.D533N|PDE2A_ENST00000540345.1_Missense_Mutation_p.D780N|PDE2A_ENST00000544570.1_Missense_Mutation_p.D782N	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	789	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TTGTTTCGGTCGTAGCCCACT	0.597000													9	18					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328721	3328721	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:3328721G>T	ENST00000378398.3	+	10	2045	c.1963G>T	c.(1963-1965)Gcg>Tcg	p.A655S	PRDM16_ENST00000511072.1_Missense_Mutation_p.A655S|PRDM16_ENST00000442529.2_Missense_Mutation_p.A654S|PRDM16_ENST00000514189.1_Missense_Mutation_p.A655S|PRDM16_ENST00000441472.2_Missense_Mutation_p.A654S|PRDM16_ENST00000378391.2_Missense_Mutation_p.A654S|PRDM16_ENST00000270722.5_Missense_Mutation_p.A654S|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	654					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGGCGGCTTGGCGCCCCCGGG	0.682000			T	EVI1	"""MDS, AML"""								19	45					0.00074312	0.000764795	1	1	0
FBN1	2200	broad.mit.edu	37	15	48707938	48707938	+	Missense_Mutation	SNP	T	T	A	rs143677764		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:48707938T>A	ENST00000316623.5	-	64	8301	c.7846A>T	c.(7846-7848)Atc>Ttc	p.I2616F	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2616	EGF-like 46; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCTCCGCAGATGTGAGCGCTG	0.532000													30	87					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400799	195400799	+	RNA	SNP	G	G	A	rs7635172	by1000genomes	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:195400799G>A	ENST00000445430.1	+	0	1395																											CAAACTCGCTGTTGGACCTGG	0.597000													5	101					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46982566	46982566	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:46982566T>C	ENST00000371253.2	-	9	993	c.778A>G	c.(778-780)Att>Gtt	p.I260V	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000283297.5_Missense_Mutation_p.I63V	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	260					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CCAAAGACAATGTCATTACAC	0.428000													14	19					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111495093	111495093	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:111495093T>C	ENST00000369763.4	-	2	803	c.413A>G	c.(412-414)cAt>cGt	p.H138R	LRIF1_ENST00000494675.1_Intron|LRIF1_ENST00000485275.2_Intron|RP11-96K19.2_ENST00000440689.1_RNA	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						TTTCACACCATGACTCTGAAC	0.358000													32	54					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197297973	197297973	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:197297973G>C	ENST00000367400.3	+	2	627	c.492G>C	c.(490-492)caG>caC	p.Q164H	CRB1_ENST00000535699.1_Missense_Mutation_p.Q95H|CRB1_ENST00000538660.1_Missense_Mutation_p.Q164H|CRB1_ENST00000367399.2_Missense_Mutation_p.Q164H	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	164	EGF-like 4; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCGTGTGCCAGGATGGAATTG	0.512000													10	44					0	0	1	0	0
MEMO1	51072	broad.mit.edu	37	2	32108493	32108493	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:32108493C>A	ENST00000295065.4	-	7	928	c.619G>T	c.(619-621)Ggg>Tgg	p.G207W	MEMO1_ENST00000490459.1_Intron|MEMO1_ENST00000426310.2_Missense_Mutation_p.G184W|DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000379383.3_Missense_Mutation_p.G210W|MEMO1_ENST00000404530.1_Missense_Mutation_p.G207W	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	207					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					TAAATCTCCCCCTGGGATTCA	0.318000													85	250					7.15876e-41	8.58357e-41	1	1	0
LINC00969	440993	broad.mit.edu	37	3	195400795	195400795	+	RNA	SNP	C	C	T	rs7615357	by1000genomes	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:195400795C>T	ENST00000445430.1	+	0	1391																											GGGGCAAACTCGCTGTTGGAC	0.592000													6	99					0	0	1	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80203722	80203722	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:80203722C>G	ENST00000450142.2	-	10	1574	c.1308G>C	c.(1306-1308)tgG>tgC	p.W436C	PPP1R12A_ENST00000437004.2_Missense_Mutation_p.W436C|PPP1R12A_ENST00000261207.5_Missense_Mutation_p.W436C|PPP1R12A_ENST00000550107.1_Missense_Mutation_p.W436C|PPP1R12A_ENST00000546369.1_Missense_Mutation_p.W349C	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	436						contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						GTCCTAACCTCCAAGTTGCAG	0.388000													18	20					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202343121	202343121	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:202343121G>A	ENST00000194530.3	+	10	1232	c.867G>A	c.(865-867)ttG>ttA	p.L289L	STRADB_ENST00000392249.2_Silent_p.L289L	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	289	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						ATAGCCCATTGGATATCAGTA	0.388000													34	86					0	0	1	0	0
RAD51D	5892	broad.mit.edu	37	17	33430519	33430519	+	Silent	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:33430519C>A	ENST00000345365.6	-	7	876	c.621G>T	c.(619-621)tcG>tcT	p.S207S	RAD51D_ENST00000590380.1_5'UTR|RAD51D_ENST00000360276.3_Silent_p.S162S|RAD51D_ENST00000590016.1_Silent_p.S227S|RAD51D_ENST00000460118.2_Silent_p.S88S|RAD51D_ENST00000394589.4_Silent_p.S207S|RAD51L3-RFFL_ENST00000593039.1_Silent_p.S48S|RAD51D_ENST00000335858.7_Silent_p.S95S	NM_002878.3	NP_002869.3	O75771	RA51D_HUMAN	RAD51 paralog D	207					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						CCGCAGTGACCGAGTCCACAA	0.567000								Direct reversal of damage					24	23					6.32553e-13	7.23336e-13	1	1	0
SHROOM4	57477	broad.mit.edu	37	X	50350964	50350964	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:50350964C>T	ENST00000376020.2	-	6	3203	c.3178G>A	c.(3178-3180)Gag>Aag	p.E1060K	SHROOM4_ENST00000289292.7_Missense_Mutation_p.E1060K|SHROOM4_ENST00000460112.3_Missense_Mutation_p.E944K	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1060					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					ATGTGACTCTCTGAGAAGGCA	0.562000													18	6					0	0	1	0	0
FAM73A	374986	broad.mit.edu	37	1	78279491	78279491	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:78279491A>G	ENST00000370791.3	+	6	742	c.710A>G	c.(709-711)gAt>gGt	p.D237G	FAM73A_ENST00000443751.2_Missense_Mutation_p.D199G	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	237						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		CAGGCTGAAGATGAAGCCTGT	0.393000													7	113					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363783	22363783	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:22363783T>C	ENST00000397121.2	-	3	1053	c.736A>G	c.(736-738)Att>Gtt	p.I246V		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCAGTATGAATTATCTTATGT	0.358000													9	226					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72647899	72647899	+	Splice_Site	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:72647899C>A	ENST00000268097.5	-	3	916		c.e3+1		RP11-106M3.2_ENST00000379915.4_RNA|HEXA_ENST00000429918.2_Splice_Site|HEXA_ENST00000566304.1_Splice_Site|HEXA_ENST00000457859.2_Splice_Site|HEXA_ENST00000567159.1_Splice_Site	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)						cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						CAATTTGTTACCTCGGAGAGC	0.473000													35	45					5.8336e-16	6.73318e-16	1	1	0
MTTP	4547	broad.mit.edu	37	4	100532497	100532497	+	Missense_Mutation	SNP	C	C	T	rs148696330		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:100532497C>T	ENST00000457717.1	+	15	2132	c.1876C>T	c.(1876-1878)Cgt>Tgt	p.R626C	MTTP_ENST00000511045.1_Missense_Mutation_p.R653C|RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000265517.5_Missense_Mutation_p.R626C	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	626	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity	p.R626C(1)|p.R626S(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	AGGTAGTCCCCGTTCGGCATC	0.443000													42	183					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81746959	81746959	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:81746959C>T	ENST00000550584.2	-	16	2228	c.1933G>A	c.(1933-1935)Gat>Aat	p.D645N	PPFIA2_ENST00000550359.2_Missense_Mutation_p.D492N|PPFIA2_ENST00000541570.2_Missense_Mutation_p.D212N|PPFIA2_ENST00000333447.7_Missense_Mutation_p.D627N|PPFIA2_ENST00000549325.1_Missense_Mutation_p.D627N|PPFIA2_ENST00000548586.1_Missense_Mutation_p.D645N|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000552948.1_Missense_Mutation_p.D645N|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000407050.4_Missense_Mutation_p.D571N|PPFIA2_ENST00000549396.1_Missense_Mutation_p.D645N|PPFIA2_ENST00000443686.3_Missense_Mutation_p.D546N	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	571										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GTCTGGGCATCGGAATGACCA	0.388000													24	71					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28421842	28421842	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:28421842T>A	ENST00000261609.7	-	62	9613	c.9505A>T	c.(9505-9507)Acc>Tcc	p.T3169S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3169					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCTTCATCGGTCAGAGCCAGG	0.463000													52	191					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33113490	33113490	+	Silent	SNP	C	C	T	rs138473952		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:33113490C>T	ENST00000306065.4	-	18	1823	c.1665G>A	c.(1663-1665)tcG>tcA	p.S555S		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	555					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CAAGTCTGCACGACTCCACGT	0.537000													70	61					0	0	1	0	0
HDAC3	8841	broad.mit.edu	37	5	141004838	141004838	+	Missense_Mutation	SNP	A	A	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:141004838A>C	ENST00000305264.3	-	14	1233	c.1154T>G	c.(1153-1155)cTg>cGg	p.L385R	AC008781.7_ENST00000422040.1_RNA|HDAC3_ENST00000469207.1_5'UTR	NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	385					anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	GTCATAGGTCAGGAGGTCTGC	0.517000													12	167					0	0	1	0	0
HSPE1	3336	broad.mit.edu	37	2	198367975	198367975	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:198367975G>A	ENST00000233893.5	+	4	744	c.301G>A	c.(301-303)Gta>Ata	p.V101I	HSPE1_ENST00000465573.1_3'UTR|HSPE1_ENST00000409468.1_3'UTR|MOB4_ENST00000604458.1_Intron|HSPE1_ENST00000409729.1_Missense_Mutation_p.V46I	NM_002157.2	NP_002148.1			heat shock 10kDa protein 1											lung(1)	1			Epithelial(96;0.225)			TGGAAAGTACGTAGACTGAAA	0.328000													4	132					0	0	1	0	0
MRPS17	51373	broad.mit.edu	37	7	56020902	56020902	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:56020902G>A	ENST00000285298.4	+	2	143	c.14G>A	c.(13-15)cGc>cAc	p.R5H	MRPS17_ENST00000426595.1_Missense_Mutation_p.R100H	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	5					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCCGTAGTTCGCTCATCCGTC	0.448000													7	252					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106876290	106876290	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr9:106876290G>A	ENST00000286398.7	+	12	1748	c.1460G>A	c.(1459-1461)cGt>cAt	p.R487H	SMC2_ENST00000374793.3_Missense_Mutation_p.R487H|SMC2_ENST00000303219.8_Missense_Mutation_p.R487H|SMC2_ENST00000374787.3_Missense_Mutation_p.R487H	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	487					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						CAGCTGTCTCGTGATATTGGT	0.343000													56	249					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11049448	11049448	+	RNA	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr21:11049448A>T	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGAAAACTTACTTGCAGTTC	0.403000													9	322					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804440	115804440	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:115804440G>A	ENST00000369295.2	+	1	635	c.549G>A	c.(547-549)tgG>tgA	p.W183*		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	183					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GCACCGTGTGGGCCATCTCGG	0.701000													25	23					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132770	91132770	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:91132770C>A	ENST00000373094.1	+	2	2376	c.1531C>A	c.(1531-1533)Cct>Act	p.P511T	PCDH11X_ENST00000504220.1_Missense_Mutation_p.P511T|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P511T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.P511T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P511T|PCDH11X_ENST00000361724.1_Missense_Mutation_p.P511T|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P511T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P511T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P511T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	511	Cadherin 5.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGATGCTCCACCTGAATTCAG	0.428000													14	35					4.36969e-10	4.75469e-10	1	1	0
IGLV2-8	28817	broad.mit.edu	37	22	23165642	23165642	+	RNA	SNP	G	G	T	rs7510777		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:23165642G>T	ENST00000390317.2	+	0	375																											TGATTTATGAGGTCAGTAAGC	0.572000													56	385					2.26907e-38	2.70753e-38	1	1	0
RBFOX1	54715	broad.mit.edu	37	16	7383039	7383039	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:7383039G>A	ENST00000355637.4	+	1	289	c.37G>A	c.(37-39)Ggc>Agc	p.G13S	RBFOX1_ENST00000550418.1_Intron|RBFOX1_ENST00000553186.1_Intron|RBFOX1_ENST00000552089.1_Intron|RBFOX1_ENST00000311745.5_Missense_Mutation_p.G13S|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000436368.2_Missense_Mutation_p.G13S|RBFOX1_ENST00000547372.1_Intron|RBFOX1_ENST00000340209.4_5'UTR|RBFOX1_ENST00000547338.1_Intron|RBFOX1_ENST00000422070.4_Intron	NM_145893.2	NP_665900.1	Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	242					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GCATCCTTATGGCGTGCCTAT	0.493000													102	181					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326923	57326923	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:57326923G>T	ENST00000326441.9	-	10	3250	c.2887C>A	c.(2887-2889)Cgc>Agc	p.R963S	ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.R837S|PEG3_ENST00000423103.2_Missense_Mutation_p.R963S|PEG3_ENST00000598410.1_Missense_Mutation_p.R839S|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	963					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R963C(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTCGAGGGCGAAATGTTTGT	0.473000													36	122					4.92203e-23	5.73462e-23	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113293461	113293461	+	Silent	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:113293461A>G	ENST00000297405.5	-	59	9694	c.9450T>C	c.(9448-9450)ccT>ccC	p.P3150P	CSMD3_ENST00000455883.2_Silent_p.P2981P|CSMD3_ENST00000343508.3_Silent_p.P3110P|CSMD3_ENST00000352409.3_Silent_p.P3080P	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3150	Sushi 23.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTCTAACTGAAGGTCCAGAAA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	132					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602745	10602745	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:10602745G>A	ENST00000171111.5	-	3	1380	c.833C>T	c.(832-834)cCg>cTg	p.P278L	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.P278L	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	278	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CAGGAAGTTCGGCGTCAACGA	0.612000													46	35					0	0	1	0	0
PIGX	54965	broad.mit.edu	37	3	196449419	196449419	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:196449419A>T	ENST00000314118.4	+	3	469	c.187A>T	c.(187-189)Ata>Tta	p.I63L	PIGX_ENST00000541663.1_5'UTR|PIGX_ENST00000421265.1_Missense_Mutation_p.I63L|PIGX_ENST00000495440.1_3'UTR	NM_017861.3	NP_060331.3	Q8TBF5	PIGX_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class X	104					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(5)|lung(4)|stomach(1)	11	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)		AGAGAGAAACATAACAGAGGT	0.383000													54	313					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21989429	21989429	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:21989429C>T	ENST00000292779.3	+	4	1238	c.1077C>T	c.(1075-1077)ggC>ggT	p.G359G		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	359										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CCACCAATGGCGGGCAGCCCT	0.652000													18	31					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37693680	37693680	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:37693680G>A	ENST00000248901.6	+	5	497	c.310G>A	c.(310-312)Gag>Aag	p.E104K	CYTH4_ENST00000405206.3_Missense_Mutation_p.E104K|CYTH4_ENST00000439667.1_3'UTR|CYTH4_ENST00000402997.1_Missense_Mutation_p.E104K	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	104	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GTATAAAGGCGAGGGCCTCAA	0.547000													35	104					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071802	134071802	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:134071802G>A	ENST00000264360.4	+	1	1333	c.507G>A	c.(505-507)ctG>ctA	p.L169L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	169	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACTTCTCCCTGGACGTGCAGA	0.637000													14	71					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	41001261	41001261	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:41001261C>T	ENST00000253799.3	+	2	1774	c.1747C>T	c.(1747-1749)Ctc>Ttc	p.L583F	AOC2_ENST00000452774.2_Missense_Mutation_p.L583F	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	583					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		ACCCCGCTACCTCTACCTGGC	0.607000													23	98					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	158991674	158991674	+	Splice_Site	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:158991674T>G	ENST00000337808.6	+	1	640		c.e1+2		IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000412423.2_Splice_Site|IQCJ-SCHIP1_ENST00000527095.1_Splice_Site|IQCJ-SCHIP1_ENST00000485419.1_Intron|IQCJ-SCHIP1_ENST00000476809.1_Intron	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN								cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						TCTGACAGTGTAAGTTTTACA	0.408000													8	57					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74270112	74270112	+	Missense_Mutation	SNP	G	G	A	rs72552709		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:74270112G>A	ENST00000295897.4	+	1	157	c.68G>A	c.(67-69)cGt>cAt	p.R23H	ALB_ENST00000401494.3_Missense_Mutation_p.R23H|ALB_ENST00000415165.2_Missense_Mutation_p.R23H|ALB_ENST00000509063.1_Missense_Mutation_p.R23H|ALB_ENST00000503124.1_5'UTR	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	23	Albumin 1.		R -> C (in Redhill/Malmo-I/Tradate; associated with T-344 in Redhill).|R -> H (in Fukuoka-2/Lille/Taipei/Varese/ Komagome-3).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GGTGTGTTTCGTCGAGATGCA	0.368000													23	101					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	37					0	0	1	0	0
PHTF1	10745	broad.mit.edu	37	1	114240338	114240338	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:114240338T>C	ENST00000369604.1	-	19	2761	c.2278A>G	c.(2278-2280)Att>Gtt	p.I760V	PHTF1_ENST00000474926.1_5'UTR|PHTF1_ENST00000369598.1_Missense_Mutation_p.I715V|PHTF1_ENST00000369600.1_Missense_Mutation_p.I707V|PHTF1_ENST00000393357.2_Missense_Mutation_p.I760V|PHTF1_ENST00000369596.2_Missense_Mutation_p.I707V			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	760						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATGATTTAATTTTCCACAGC	0.383000													15	30					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119690	19119690	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:19119690C>T	ENST00000399635.2	+	1	1370	c.778C>T	c.(778-780)Cgg>Tgg	p.R260W	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	260	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					CGTCAGCCAGCGGCTCCACAT	0.617000													29	70					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682832	31682832	+	Silent	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:31682832C>A	ENST00000319386.3	+	11	2397	c.1404C>A	c.(1402-1404)gcC>gcA	p.A468A	CCDC129_ENST00000409210.1_Silent_p.A524A|CCDC129_ENST00000407970.3_Silent_p.A616A|CCDC129_ENST00000451887.2_Silent_p.A642A			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	616										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						ACTCTGAGGCCCCACGAGAAG	0.488000													18	100					9.16793e-09	9.84556e-09	1	1	0
RFX7	64864	broad.mit.edu	37	15	56387143	56387143	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:56387143T>C	ENST00000423270.1	-	9	2782	c.2783A>G	c.(2782-2784)cAc>cGc	p.H928R	RFX7_ENST00000422057.1_Missense_Mutation_p.H831R|RFX7_ENST00000317318.6_Missense_Mutation_p.H928R|RFX7_ENST00000559447.2_Missense_Mutation_p.H831R	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	831					regulation of transcription, DNA-dependent	nucleus	DNA binding	p.H928L(1)|p.H831L(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GCTGGAAGTGTGAGATGACAT	0.502000													3	31					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14720106	14720106	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr9:14720106G>A	ENST00000380911.3	-	2	830	c.786C>T	c.(784-786)atC>atT	p.I262I		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	262					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		AAACTCCTGGGATAAAGGAAT	0.463000													41	22					0	0	1	0	0
FAM192A	80011	broad.mit.edu	37	16	57188276	57188276	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:57188276C>T	ENST00000309137.8	-	7	949	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	FAM192A_ENST00000569266.1_Missense_Mutation_p.E231K|FAM192A_ENST00000567439.1_Missense_Mutation_p.E231K|FAM192A_ENST00000389447.5_Missense_Mutation_p.E231K|FAM192A_ENST00000564108.1_Missense_Mutation_p.E231K|FAM192A_ENST00000566077.1_Missense_Mutation_p.E154K	NM_024946.2	NP_079222.1	Q9GZU8	F192A_HUMAN	family with sequence similarity 192, member A	231						nucleus				endometrium(2)|large_intestine(3)|lung(4)|prostate(2)	11						ATGGTGCCTTCGCTGTCTGAG	0.602000													15	32					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89345072	89345072	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:89345072T>G	ENST00000380265.5	+	14	1957	c.1774T>G	c.(1774-1776)Tta>Gta	p.L592V	HERC6_ENST00000264346.7_Missense_Mutation_p.L592V	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	592					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		ACTCTCCAACTTATTAAACTT	0.303000													3	17					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98469373	98469373	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:98469373G>A	ENST00000339364.5	-	2	500	c.381C>T	c.(379-381)gaC>gaT	p.D127D		NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	127						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CTGGCTCATCGTCACAGGTGA	0.537000													36	91					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Splice_Site	SNP	C	C	A	rs55863639		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:7579312C>A	ENST00000420246.2	-	4	507	c.375_splice	c.e4+1	p.T125_splice	TP53_ENST00000359597.4_Splice_Site_p.T125_splice|TP53_ENST00000413465.2_Splice_Site_p.T125_splice|TP53_ENST00000445888.2_Splice_Site_p.T125_splice|TP53_ENST00000455263.2_Splice_Site_p.T125_splice|TP53_ENST00000269305.4_Splice_Site_p.T125_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	125	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		T -> A (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(51)|p.0?(8)|p.?(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			48	23					3.21987e-24	3.76923e-24	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25225136	25225136	+	RNA	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:25225136C>G	ENST00000551631.2	+	0	129					NR_001293.1																						TATGGATGGCCCTTAGATTTT	0.368000													4	20					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39648653	39648653	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr14:39648653G>A	ENST00000216832.4	+	8	847	c.780G>A	c.(778-780)caG>caA	p.Q260Q	PNN_ENST00000557680.1_3'UTR	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	260	Glu-rich.|Necessary for interaction with RNPS1.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AAGAGTCACAGAGAAAAATGA	0.323000													15	36					0	0	1	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35577278	35577278	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr14:35577278A>G	ENST00000555644.1	-	5	922	c.569T>C	c.(568-570)tTa>tCa	p.L190S	PPP2R3C_ENST00000261475.5_Intron			Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	0						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		AAATACTTATAAAAGCACAGA	0.308000													74	28					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19232402	19232402	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:19232402G>A	ENST00000450333.2	-	6	460	c.423C>T	c.(421-423)ttC>ttT	p.F141F	TMEM161A_ENST00000162044.9_Silent_p.F244F|TMEM161A_ENST00000587583.2_Silent_p.F219F	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	244					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			GCAGGCCTGGGAAGGTGAGGA	0.652000													19	33					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357716	55357716	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:55357716G>C	ENST00000524622.1	-	6	712	c.51C>G	c.(49-51)gaC>gaG	p.D17E	TESPA1_ENST00000449076.1_Missense_Mutation_p.D155E|TESPA1_ENST00000532804.1_Missense_Mutation_p.D17E|TESPA1_ENST00000531122.1_Missense_Mutation_p.D17E|TESPA1_ENST00000316577.8_Missense_Mutation_p.D155E|TESPA1_ENST00000524959.1_5'UTR	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	155																	CTTGCACTTTGTCCAGAATTT	0.428000													31	121					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357715	55357715	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:55357715T>A	ENST00000524622.1	-	6	713	c.52A>T	c.(52-54)Aaa>Taa	p.K18*	TESPA1_ENST00000449076.1_Nonsense_Mutation_p.K156*|TESPA1_ENST00000532804.1_Nonsense_Mutation_p.K18*|TESPA1_ENST00000531122.1_Nonsense_Mutation_p.K18*|TESPA1_ENST00000316577.8_Nonsense_Mutation_p.K156*|TESPA1_ENST00000524959.1_5'UTR	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	156																	TCTTGCACTTTGTCCAGAATT	0.428000													33	119					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283070	69283070	+	Silent	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:69283070C>A	ENST00000338352.2	+	1	730	c.696C>A	c.(694-696)ccC>ccA	p.P232P		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	232	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						TGAAGACCCCCATCGAGGTGA	0.612000													22	9					1.50039e-11	1.69222e-11	1	1	0
CREM	1390	broad.mit.edu	37	10	35477202	35477202	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:35477202A>G	ENST00000333809.8	+	6	685	c.631A>G	c.(631-633)Aca>Gca	p.T211A	CREM_ENST00000345491.3_Missense_Mutation_p.T162A|CREM_ENST00000342105.3_Missense_Mutation_p.T107A|CREM_ENST00000337656.4_Missense_Mutation_p.T162A|CREM_ENST00000354759.3_Intron|CREM_ENST00000484283.1_Intron|CREM_ENST00000479070.1_Missense_Mutation_p.T162A|CREM_ENST00000348787.2_Intron|CREM_ENST00000463960.1_Intron|CREM_ENST00000463314.1_5'UTR|CREM_ENST00000439705.1_Intron|CREM_ENST00000460270.1_Intron|CREM_ENST00000429130.3_Missense_Mutation_p.T195A|CREM_ENST00000374721.3_Intron|CREM_ENST00000395887.3_Missense_Mutation_p.T132A|CREM_ENST00000361599.4_Missense_Mutation_p.T132A|CREM_ENST00000395895.2_Missense_Mutation_p.T211A|CREM_ENST00000474362.1_Intron|CREM_ENST00000374728.3_Intron|CREM_ENST00000374734.3_Intron	NM_183011.1	NP_898829.1	Q03060	CREM_HUMAN	cAMP responsive element modulator	211					cell differentiation|multicellular organismal development|signal transduction|spermatogenesis	nucleus	cAMP response element binding protein binding|protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14						GCAGGCATTAACAATGACAAA	0.453000													25	81					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50687144	50687144	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:50687144G>T	ENST00000230658.7	+	5	1387	c.802G>T	c.(802-804)Gcc>Tcc	p.A268S	ISL1_ENST00000511384.1_Intron|ISL1_ENST00000505475.2_3'UTR	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	268	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				CATGGTGGCTGCCAGTCCAGA	0.527000													6	30					0.0215528	0.0216404	1	1	0
PPFIA2	8499	broad.mit.edu	37	12	81746960	81746960	+	Silent	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:81746960G>C	ENST00000550584.2	-	16	2227	c.1932C>G	c.(1930-1932)tcC>tcG	p.S644S	PPFIA2_ENST00000550359.2_Silent_p.S491S|PPFIA2_ENST00000541570.2_Silent_p.S211S|PPFIA2_ENST00000333447.7_Silent_p.S626S|PPFIA2_ENST00000549325.1_Silent_p.S626S|PPFIA2_ENST00000548586.1_Silent_p.S644S|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000552948.1_Silent_p.S644S|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000407050.4_Silent_p.S570S|PPFIA2_ENST00000549396.1_Silent_p.S644S|PPFIA2_ENST00000443686.3_Silent_p.S545S	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	570										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCTGGGCATCGGAATGACCAC	0.393000													24	71					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35614747	35614747	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:35614747G>A	ENST00000353139.5	-	14	2185	c.1704C>T	c.(1702-1704)ttC>ttT	p.F568F	ACACA_ENST00000394406.2_Silent_p.F531F|ACACA_ENST00000335166.5_Silent_p.F453F|ACACA_ENST00000360679.3_Silent_p.F473F	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	531	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TATTGCTGCGGAAATTTAGCT	0.413000													21	90					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854286	88854286	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:88854286C>T	ENST00000537554.1	-	2	4270	c.708G>A	c.(706-708)gcG>gcA	p.A236A	CNR1_ENST00000535130.1_Silent_p.A236A|CNR1_ENST00000369499.2_Silent_p.A236A|CNR1_ENST00000468898.1_Silent_p.A203A|CNR1_ENST00000428600.2_Silent_p.A236A|CNR1_ENST00000369501.2_Silent_p.A236A|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000549890.1_Silent_p.A236A|CNR1_ENST00000549716.1_Silent_p.A175A	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	236					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding	p.A236A(2)		breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TCAGGCAAAACGCCACCACGG	0.562000													12	36					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112647686	112647686	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:112647686C>T	ENST00000471858.1	-	4	909	c.677G>A	c.(676-678)aGt>aAt	p.S226N	CD200R1_ENST00000308611.3_Missense_Mutation_p.S249N|CD200R1_ENST00000295863.4_Missense_Mutation_p.S204N	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	226	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TATGTACAGACTCTTGTTGCC	0.388000													48	114					0	0	1	0	0
MEX3D	399664	broad.mit.edu	37	19	1556840	1556840	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:1556840C>T	ENST00000402693.4	-	2	677	c.678G>A	c.(676-678)gtG>gtA	p.V226V	MEX3D_ENST00000388824.6_Silent_p.V226V	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	226	KH 1.				mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGCCGGTCACGATGAAGA	0.662000													20	61					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33137563	33137563	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:33137563G>A	ENST00000375030.2	+	20	2036	c.1418G>A	c.(1417-1419)cGt>cAt	p.R473H	C10orf68_ENST00000375028.3_Missense_Mutation_p.R518H|C10orf68_ENST00000375025.4_Missense_Mutation_p.R578H			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	514										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						TCCGTACAACGTCAAGAAGGT	0.294000													97	132					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4008965	4008965	+	Silent	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:4008965G>T	ENST00000404826.2	+	11	1762	c.1623G>T	c.(1621-1623)gcG>gcT	p.A541A	SDK1_ENST00000389531.3_Silent_p.A541A	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	541	Ig-like C2-type 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TACAGATCGCGCCCGTCTTCA	0.552000													82	175					3.73172e-31	4.43141e-31	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151962121	151962121	+	Splice_Site	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:151962121A>T	ENST00000355193.2	-	8	1403		c.e8+1		KMT2C_ENST00000262189.6_Splice_Site					lysine (K)-specific methyltransferase 2C																		ATGAAAACTTACTTGCAGTTC	0.398000													12	379					0	0	1	0	0
SRRD	402055	broad.mit.edu	37	22	26886031	26886031	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:26886031G>A	ENST00000215917.6	+	5	645	c.631G>A	c.(631-633)Ggg>Agg	p.G211R		NM_001013694.2	NP_001013716.2	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	211					rhythmic process					endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						GAGTATTCGCGGGGAGCCTAC	0.473000													29	74					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123166599	123166599	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:123166599G>A	ENST00000462833.1	-	1	2006	c.794C>T	c.(793-795)cCg>cTg	p.P265L		NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	265					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CAGCTGGAGCGGGGGCCGCGC	0.672000													31	69					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108044179	108044179	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:108044179G>T	ENST00000278612.8	-	13	1637	c.1532C>A	c.(1531-1533)tCa>tAa	p.S511*		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	511					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TGAAACAAATGAAGTTATTGG	0.368000													28	56					1.12875e-08	1.20693e-08	1	1	0
SNCAIP	9627	broad.mit.edu	37	5	121786360	121786360	+	Silent	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:121786360G>T	ENST00000261367.7	+	12	3387	c.1959G>T	c.(1957-1959)cgG>cgT	p.R653R	CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000261368.8_Silent_p.R606R|SNCAIP_ENST00000379536.2_Silent_p.R546R|CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379538.3_Silent_p.R240R|SNCAIP_ENST00000542191.1_Silent_p.R164R|SNCAIP_ENST00000414317.2_Silent_p.R208R|SNCAIP_ENST00000379533.2_Silent_p.R653R|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000509993.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000503116.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	606					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCTCCAGCCGGGCTAGACCCA	0.463000													22	40					7.45023e-12	8.44131e-12	1	1	0
ECE2	9718	broad.mit.edu	37	3	184005706	184005706	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:184005706G>A	ENST00000402825.3	+	11	1699	c.1699G>A	c.(1699-1701)Gcc>Acc	p.A567T	ECE2_ENST00000359140.4_Missense_Mutation_p.A420T|ECE2_ENST00000357474.5_Missense_Mutation_p.A495T|ECE2_ENST00000404464.3_Missense_Mutation_p.A449T|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	567	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTTCGTGAAGGCCACGTTTGA	0.478000													22	120					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4229232	4229232	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr20:4229232G>A	ENST00000379453.4	-	1	489	c.373C>T	c.(373-375)Cgc>Tgc	p.R125C		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	125					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	TGCAGGTGGCGGTTGCAGGCC	0.637000													14	32					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906883	26906883	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:26906883T>A	ENST00000231021.4	-	4	760	c.588A>T	c.(586-588)aaA>aaT	p.K196N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	196	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TATAGACCACTTTGGCACTAT	0.388000													23	51					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72748110	72748110	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:72748110C>A	ENST00000357731.4	-	1	307	c.68G>T	c.(67-69)aGc>aTc	p.S23I	NEGR1_ENST00000434200.1_Missense_Mutation_p.S21I	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	23					cell adhesion	anchored to membrane|plasma membrane		p.S23N(1)		endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GCAGCACAGGCTGAGGAGCAC	0.627000													4	36					0.00024832	0.000256632	1	1	0
WDR72	256764	broad.mit.edu	37	15	54025296	54025296	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:54025296G>A	ENST00000396328.1	-	2	290	c.51C>T	c.(49-51)ccC>ccT	p.P17P	WDR72_ENST00000559418.1_Silent_p.P17P|WDR72_ENST00000557913.1_Silent_p.P17P|WDR72_ENST00000360509.5_Silent_p.P17P	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	17										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TGATGCTGTGGGGAGGGGCCT	0.512000													20	91					0	0	1	0	0
OR10V1	390201	broad.mit.edu	37	11	59480656	59480656	+	Silent	SNP	G	G	A	rs146924217	by1000genomes	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:59480656G>A	ENST00000307552.2	-	1	681	c.663C>T	c.(661-663)ttC>ttT	p.F221F		NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						CTACCACGATGAAGACATAGG	0.512000													23	42					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1075769	1075769	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:1075769C>T	ENST00000441003.2	+	2	222	c.195C>T	c.(193-195)tcC>tcT	p.S65S	MUC2_ENST00000359061.5_Silent_p.S65S	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	65	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACTTCGCCTCCGACTGCCGAG	0.642000													13	17					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66286159	66286159	+	Splice_Site	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:66286159C>G	ENST00000273854.3	-	6	2127	c.1527_splice	c.e6+1	p.K509_splice	EPHA5_ENST00000354839.4_Splice_Site_p.K509_splice|EPHA5_ENST00000511294.1_Splice_Site_p.K509_splice|EPHA5_ENST00000432638.2_Splice_Site_p.K345_splice	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	509	Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TTAGTCTTACCTTTTCAAAAT	0.318000										TSP Lung(17;0.13)			34	42					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117503896	117503896	+	Silent	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:117503896C>G	ENST00000393203.2	+	5	1392	c.1245C>G	c.(1243-1245)tcC>tcG	p.S415S		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	415	Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TGAATGCTTCCAAGGTCCCCG	0.512000													20	58					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79461950	79461950	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:79461950C>T	ENST00000264895.6	+	74	12151	c.11711C>T	c.(11710-11712)gCg>gTg	p.A3904V		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3899					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CAGACTGGGGCGTCCATTGGC	0.493000													7	40					0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144966262	144966262	+	Silent	SNP	G	G	A	rs146914833	byFrequency	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:144966262G>A	ENST00000409214.1	-	4	365	c.87C>T	c.(85-87)gtC>gtT	p.V29V	GTDC1_ENST00000392869.1_Silent_p.V29V|GTDC1_ENST00000542155.1_Silent_p.V29V|GTDC1_ENST00000392867.3_Silent_p.V29V|GTDC1_ENST00000463875.2_Intron|GTDC1_ENST00000241391.5_Silent_p.V29V|GTDC1_ENST00000344850.4_Silent_p.V29V|GTDC1_ENST00000409298.1_Silent_p.V29V	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	29					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		GGGTATAAACGACACAGTCTC	0.438000													21	33					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7721970	7721970	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:7721970G>A	ENST00000486284.1	+	9	2960	c.2686G>A	c.(2686-2688)Gta>Ata	p.V896I	GRM7_ENST00000403881.1_Missense_Mutation_p.V896I|GRM7_ENST00000357716.4_Missense_Mutation_p.V896I|GRM7_ENST00000389336.4_Missense_Mutation_p.V896I|GRM7_ENST00000402647.2_Missense_Mutation_p.V896I	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	896					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.V896I(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CTGTGAAAACGTAGACCCAAA	0.512000													24	11					0	0	1	0	0
SLC17A5	26503	broad.mit.edu	37	6	74304856	74304856	+	Missense_Mutation	SNP	C	C	T	rs141341430	byFrequency	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:74304856C>T	ENST00000355773.5	-	11	1700	c.1432G>A	c.(1432-1434)Gcc>Acc	p.A478T		NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	478					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TCACCTTTGGCGAATAGTGTA	0.363000													29	79					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45411394	45411394	+	Silent	SNP	G	G	T	rs150452217		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:45411394G>T	ENST00000558996.1	-	6	861	c.807C>A	c.(805-807)ccC>ccA	p.P269P	DUOXA1_ENST00000559014.1_Silent_p.P314P|DUOXA1_ENST00000560572.1_Silent_p.P314P|DUOXA1_ENST00000558422.1_Silent_p.P269P|DUOXA1_ENST00000267803.4_Silent_p.P314P|DUOXA1_ENST00000430224.2_Silent_p.P269P	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	314					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		CCTGGGACTTGGGACTGTCAG	0.552000													25	86					4.72057e-08	4.98283e-08	1	1	0
PEX11A	8800	broad.mit.edu	37	15	90229714	90229714	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:90229714C>T	ENST00000300056.3	-	2	269	c.120G>A	c.(118-120)aaG>aaA	p.K40K	PEX11A_ENST00000561224.1_Silent_p.K40K|PEX11A_ENST00000559170.1_Intron|PEX11A_ENST00000557982.1_Intron|PEX11A_ENST00000561257.1_Silent_p.K40K	NM_001271573.1	NP_001258502.1	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	40					cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane				endometrium(2)|large_intestine(2)|lung(3)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TCATTACCACCTTCTCTTTGC	0.408000													15	132					0	0	1	0	0
SLC22A1	6580	broad.mit.edu	37	6	160557620	160557620	+	Silent	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:160557620A>T	ENST00000366963.4	+	6	1146	c.999A>T	c.(997-999)tcA>tcT	p.S333S	SLC22A1_ENST00000457470.2_Silent_p.S333S|SLC22A1_ENST00000324965.4_Silent_p.S333S	NM_003057.2|NM_153187.1	NP_003048.1|NP_694857.1	O15245	S22A1_HUMAN	solute carrier family 22 (organic cation transporter), member 1	333						basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding		SLC22A1/CUTA(2)	breast(1)|endometrium(3)|large_intestine(3)|lung(13)|upper_aerodigestive_tract(1)	21		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TGAGCCCTTCATTTGCAGACC	0.582000													58	73					0	0	1	0	0
DMAP1	55929	broad.mit.edu	37	1	44680075	44680075	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:44680075G>A	ENST00000372289.2	+	2	422	c.159G>A	c.(157-159)atG>atA	p.M53I	DMAP1_ENST00000361745.6_Missense_Mutation_p.M53I|DMAP1_ENST00000315913.5_Missense_Mutation_p.M53I	NM_019100.4	NP_061973.1	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	53					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(166;0.155)					CCGAGGGCATGCACCGGGAAG	0.512000													5	146					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363785	22363785	+	Missense_Mutation	SNP	A	A	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:22363785A>C	ENST00000397121.2	-	3	1051	c.734T>G	c.(733-735)aTa>aGa	p.I245R		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGTATGAATTATCTTATGTTT	0.363000													8	234					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178423653	178423653	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:178423653G>A	ENST00000448150.3	+	12	2845	c.2027G>A	c.(2026-2028)cGc>cAc	p.R676H	RASAL2_ENST00000367649.3_Missense_Mutation_p.R694H|RASAL2_ENST00000462775.1_Missense_Mutation_p.R546H	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	546					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						GGAATGAAGCGCTTTCTTTTG	0.408000													29	132					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123625035	123625035	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:123625035C>G	ENST00000327930.2	-	1	218	c.192G>C	c.(190-192)ttG>ttC	p.L64F		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTAAGAAAGACAAGTTACAAA	0.463000													18	42					0	0	1	0	0
CDC23	8697	broad.mit.edu	37	5	137548924	137548924	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:137548924G>T	ENST00000394886.2	-	1	108	c.78C>A	c.(76-78)ttC>ttA	p.F26L	CDC23_ENST00000505120.1_Missense_Mutation_p.F26L|CDC23_ENST00000394884.3_Missense_Mutation_p.F26L	NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	26					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCAAATCTGAGAAATCGCTGT	0.567000													24	52					1.10923e-09	1.20167e-09	1	1	0
TTN	7273	broad.mit.edu	37	2	179417916	179417916	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:179417916C>G	ENST00000589042.1	-	335	89935	c.89711G>C	c.(89710-89712)cGc>cCc	p.R29904P	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R28263P|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R20964P|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R20839P|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R27336P|TTN_ENST00000342175.6_Missense_Mutation_p.R21031P|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28263	Fibronectin type-III 118.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATCATTGCGAGTAACTTG	0.408000													37	71					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139768066	139768066	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr8:139768066C>T	ENST00000303045.6	-	19	2355	c.1909G>A	c.(1909-1911)Gtg>Atg	p.V637M	COL22A1_ENST00000435777.1_Missense_Mutation_p.V637M	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	637	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCAGGTCCCACGTCACCCTGC	0.572000										HNSCC(7;0.00092)			13	105					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113831862	113831862	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:113831862T>G	ENST00000512097.3	+	9	2741	c.1723T>G	c.(1723-1725)Tca>Gca	p.S575A	KCNN2_ENST00000264773.3_Missense_Mutation_p.S575A|RP11-492A10.1_ENST00000514115.1_RNA|KCNN2_ENST00000503706.1_Missense_Mutation_p.S227A			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	575						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		ACCACCAACTTCATCAGAGAG	0.468000													4	84					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122642502	122642502	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:122642502C>A	ENST00000195173.4	-	10	1537	c.1234G>T	c.(1234-1236)Gcc>Tcc	p.A412S	SEMA5B_ENST00000357599.3_Missense_Mutation_p.A412S|SEMA5B_ENST00000451055.2_Missense_Mutation_p.A466S			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	412	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GGGAGCCAGGCAGCCCTGGGG	0.562000													16	119					6.72482e-11	7.41532e-11	1	1	0
ANKRD53	79998	broad.mit.edu	37	2	71206427	71206427	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:71206427G>A	ENST00000272421.6	+	2	637	c.371G>A	c.(370-372)cGa>cAa	p.R124Q	ANKRD53_ENST00000360589.3_Missense_Mutation_p.R124Q|ANKRD53_ENST00000441349.1_Missense_Mutation_p.R90Q|ANKRD53_ENST00000457410.1_Missense_Mutation_p.R90Q|AC007040.11_ENST00000606025.1_Intron	NM_024933.3	NP_079209.3	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53	124										endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	11						GAATGGCTGCGATTCTGTCTG	0.607000													37	104					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167177	140167177	+	Silent	SNP	G	G	A	rs144742806	byFrequency	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:140167177G>A	ENST00000504120.2	+	1	1302	c.1302G>A	c.(1300-1302)tcG>tcA	p.S434S	PCDHA1_ENST00000378133.3_Silent_p.S434S|PCDHA1_ENST00000394633.3_Silent_p.S434S	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGCCTTCGCTGTGGGCCA	0.627000													57	91					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178552036	178552036	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:178552036T>A	ENST00000251582.7	-	19	2997	c.2896A>T	c.(2896-2898)Agc>Tgc	p.S966C		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	966	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GCCCGGCGGCTCTCGGGCCGG	0.687000													41	101					0	0	1	0	0
HSD17B1	3292	broad.mit.edu	37	17	40705615	40705615	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:40705615G>T	ENST00000585807.1	+	3	4144	c.424G>T	c.(424-426)Ggg>Tgg	p.G142W	HSD17B1_ENST00000225929.5_Missense_Mutation_p.G142W|RP11-400F19.8_ENST00000585572.1_RNA|RP11-400F19.6_ENST00000590513.1_RNA	NM_000413.2	NP_000404.2	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	142					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity			NS(1)|endometrium(1)|kidney(1)|lung(2)	5		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GTTGGTGACCGGGAGCGTGGG	0.627000													5	105					0.014758	0.0148785	1	1	0
KIAA1551	55196	broad.mit.edu	37	12	32135923	32135923	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:32135923C>T	ENST00000312561.4	+	4	2448	c.2034C>T	c.(2032-2034)tcC>tcT	p.S678S	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CCTGTCTTTCCCTGTGGAAAA	0.428000													15	46					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108813786	108813786	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:108813786G>T	ENST00000232603.5	-	7	635	c.553C>A	c.(553-555)Cag>Aag	p.Q185K	MORC1_ENST00000483760.1_Missense_Mutation_p.Q185K	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	185					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TCAAACTGCTGCATCAATTCT	0.338000													26	255					4.22769e-11	4.72507e-11	1	1	0
SLC22A2	6582	broad.mit.edu	37	6	160645749	160645749	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:160645749T>G	ENST00000366953.3	-	10	1847	c.1589A>C	c.(1588-1590)gAa>gCa	p.E530A	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	530					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TTGCATATTTTCGGCTTCCTC	0.413000													84	81					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100569567	100569567	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:100569567G>A	ENST00000471714.1	-	16	1493	c.1384C>T	c.(1384-1386)Cgt>Tgt	p.R462C	ABI3BP_ENST00000284322.5_Missense_Mutation_p.R413C|ABI3BP_ENST00000495063.1_Missense_Mutation_p.R462C			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	424	Pro-rich.					extracellular space		p.R413C(1)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TCCAGAATACGATCACTTGTT	0.343000													17	73					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101583097	101583097	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:101583097G>A	ENST00000310954.6	-	10	1956	c.1670C>T	c.(1669-1671)aCt>aTt	p.T557I		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	557					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AGTTTCTGCAGTGGATGTTAT	0.284000													22	78					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67574393	67574393	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:67574393G>A	ENST00000540839.3	+	10	944	c.724G>A	c.(724-726)Gat>Aat	p.D242N	FAM65A_ENST00000566522.1_3'UTR|FAM65A_ENST00000379312.3_Missense_Mutation_p.D226N|FAM65A_ENST00000428437.2_Missense_Mutation_p.D236N|FAM65A_ENST00000422602.2_Missense_Mutation_p.D242N|FAM65A_ENST00000042381.4_Missense_Mutation_p.D222N			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	226						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GTGTGTAGGCGATCAGTATGA	0.572000													19	44					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48566800	48566800	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:48566800T>G	ENST00000396577.3	+	20	2650	c.2435T>G	c.(2434-2436)aTa>aGa	p.I812R	SLC12A1_ENST00000380993.3_Missense_Mutation_p.I812R|SLC12A1_ENST00000558405.1_Missense_Mutation_p.I812R	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	812					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GGCGTGGTTATAGTCAGAATC	0.383000													11	34					0	0	1	0	0
FASTKD3	79072	broad.mit.edu	37	5	7862969	7862969	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:7862969G>C	ENST00000264669.5	-	4	1802	c.1666C>G	c.(1666-1668)Cca>Gca	p.P556A	MTRR_ENST00000502509.1_Intron|FASTKD3_ENST00000513658.1_5'UTR	NM_024091.3	NP_076996.2	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	556					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AACACTTTTGGAGCAAAATAT	0.388000													19	296					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32328384	32328384	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:32328384G>A	ENST00000357033.4	-	42	6138	c.5932C>T	c.(5932-5934)Cgt>Tgt	p.R1978C	DMD_ENST00000378677.2_Missense_Mutation_p.R1974C	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1978					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTTCTTCACGGACAGTGTGC	0.378000													12	17					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													4	85					0	0	1	0	0
ESRRA	2101	broad.mit.edu	37	11	64082285	64082285	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:64082285C>T	ENST00000405666.1	+	5	878	c.644C>T	c.(643-645)cCc>cTc	p.P215L	ESRRA_ENST00000406310.1_Missense_Mutation_p.P214L|ESRRA_ENST00000000442.6_Missense_Mutation_p.P215L			P11474	ERR1_HUMAN	estrogen-related receptor alpha	215	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						ATGCCTGACCCCGCAGGCCCT	0.582000													20	44					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031379	79031379	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:79031379A>T	ENST00000446378.2	+	2	6822	c.6791A>T	c.(6790-6792)gAa>gTa	p.E2264V		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2264						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AACGTTAAAGAAAAATCCATG	0.348000													26	62					0	0	1	0	0
PKD2	5311	broad.mit.edu	37	4	88986917	88986917	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:88986917G>A	ENST00000237596.2	+	12	2310	c.2244G>A	c.(2242-2244)aaG>aaA	p.K748K	PKD2_ENST00000502363.1_Silent_p.K166K|PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000508588.1_Silent_p.K166K	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	748	EF-hand domain.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ATTTCAGGAAGGGCCATACTG	0.433000													57	70					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163029373	163029373	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr2:163029373G>A	ENST00000188790.4	-	25	2336	c.2129C>T	c.(2128-2130)tCa>tTa	p.S710L	FAP_ENST00000443424.1_Missense_Mutation_p.S685L|AC007750.5_ENST00000418968.2_RNA	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	710					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						AATCTGTGCTGAGTTTTGAAA	0.398000													22	49					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323247	31323247	+	Missense_Mutation	SNP	G	G	T	rs72558120		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr6:31323247G>T	ENST00000412585.2	-	4	770	c.742C>A	c.(742-744)Caa>Aaa	p.Q248K		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						TCCTGAGTTTGGTCCTCGCCA	0.592000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				21	80					1.01871e-10	1.11832e-10	1	1	0
FLRT1	23769	broad.mit.edu	37	11	63884783	63884783	+	Silent	SNP	C	C	T	rs140908634		TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:63884783C>T	ENST00000246841.3	+	2	2087	c.1044C>T	c.(1042-1044)gcC>gcT	p.A348A	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	320	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CACGGGCGGCCGTGGTCAACG	0.627000													11	39					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799050	57799050	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:57799050C>A	ENST00000302622.3	+	1	649	c.626C>A	c.(625-627)gCt>gAt	p.A209D	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GTGTCTCTGGCTGTGCTACTG	0.537000													25	60					4.72057e-08	4.98283e-08	1	1	0
RBM15B	29890	broad.mit.edu	37	3	51429757	51429757	+	Silent	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:51429757G>T	ENST00000323686.4	+	1	1027	c.927G>T	c.(925-927)ctG>ctT	p.L309L		NM_013286.4	NP_037418.3	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	309					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|large_intestine(5)|lung(3)	12				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ACTACGGGCTGTACGACGACC	0.697000													19	13					5.03518e-11	5.60221e-11	1	1	0
LINC00969	440993	broad.mit.edu	37	3	195400822	195400822	+	RNA	SNP	G	G	A	rs56170658	by1000genomes	TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:195400822G>A	ENST00000445430.1	+	0	1418																											GTCTGGTCAGGCATGTGCCCT	0.572000													5	96					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7963763	7963763	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:7963763C>T	ENST00000306708.6	+	3	457	c.356C>T	c.(355-357)cCt>cTt	p.P119L	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	119						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						AAGTACTTCCCTTACCTCGTG	0.473000													38	152					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111430632	111430632	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:111430632G>T	ENST00000428084.1	-	31	3468	c.3196C>A	c.(3196-3198)Ctg>Atg	p.L1066M	DOCK4_ENST00000437633.1_Missense_Mutation_p.L1066M			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1066					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GGGCCAATCAGGGCAGGGATA	0.378000													8	14					0.00307968	0.00315635	1	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125686182	125686182	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:125686182C>T	ENST00000371126.1	-	1	652	c.410G>A	c.(409-411)cGg>cAg	p.R137Q		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	137										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CTCACTGTCCCGCAAGAGGGG	0.632000													20	37					0	0	1	0	0
GIN1	54826	broad.mit.edu	37	5	102442588	102442588	+	Silent	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:102442588T>C	ENST00000399004.2	-	3	259	c.165A>G	c.(163-165)aaA>aaG	p.K55K	GIN1_ENST00000508629.1_Silent_p.K55K	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	55					DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		GTTTTCTGTCTTTTCCAACAT	0.313000													8	18					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92929488	92929488	+	Silent	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:92929488C>T	ENST00000327111.3	+	3	2899	c.1212C>T	c.(1210-1212)cgC>cgT	p.R404R	NR2F1_ENST00000506162.1_3'UTR	NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	404					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding	p.R404R(1)		NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CTCTCATCCGCGATATGTTAC	0.582000													57	114					0	0	1	0	0
TCF7	6932	broad.mit.edu	37	5	133451660	133451660	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:133451660A>T	ENST00000395029.1	+	3	572	c.377A>T	c.(376-378)aAt>aTt	p.N126I	TCF7_ENST00000378564.1_Missense_Mutation_p.N126I|TCF7_ENST00000520958.1_Missense_Mutation_p.N11I|TCF7_ENST00000432532.2_Missense_Mutation_p.N11I|TCF7_ENST00000342854.5_Missense_Mutation_p.N126I|TCF7_ENST00000321584.4_Missense_Mutation_p.N126I|TCF7_ENST00000518915.1_Missense_Mutation_p.N11I|TCF7_ENST00000321603.6_Missense_Mutation_p.N126I|TCF7_ENST00000395023.1_Missense_Mutation_p.N11I|TCF7_ENST00000378560.4_Missense_Mutation_p.N11I			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	126					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCGCCTTCAATCTGCTCATG	0.652000													13	36					0	0	1	0	0
KBTBD2	25948	broad.mit.edu	37	7	32909365	32909365	+	Silent	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr7:32909365G>A	ENST00000304056.4	-	4	2163	c.1464C>T	c.(1462-1464)ccC>ccT	p.P488P	AVL9_ENST00000404479.1_Intron	NM_015483.2	NP_056298.2	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	488										endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|urinary_tract(1)	17			GBM - Glioblastoma multiforme(11;0.0499)			CAGTGCCAGAGGGGAGTCTTA	0.428000													26	140					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292832	102292832	+	RNA	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr15:102292832G>C	ENST00000561463.1	+	0	878																											GAAGACACTCGTGGAGGCGTC	0.597000													6	51					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21334349	21334349	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr22:21334349C>A	ENST00000399167.2	+	19	1933	c.1693C>A	c.(1693-1695)Ccc>Acc	p.P565T	LZTR1_ENST00000479606.1_3'UTR|AIFM3_ENST00000440238.2_Missense_Mutation_p.P565T|AIFM3_ENST00000465606.1_3'UTR|AIFM3_ENST00000335375.5_Missense_Mutation_p.P553T|AIFM3_ENST00000333607.6_Missense_Mutation_p.P565T|AIFM3_ENST00000399163.2_Missense_Mutation_p.P565T|AIFM3_ENST00000405089.1_Missense_Mutation_p.P571T	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GAACTACGATCCCATTGTGTC	0.622000													11	41					3.07112e-06	3.2007e-06	1	1	0
MYH3	4621	broad.mit.edu	37	17	10543023	10543023	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr17:10543023C>T	ENST00000583535.1	-	23	2866	c.2779G>A	c.(2779-2781)Gct>Act	p.A927T	MYH3_ENST00000226209.7_Missense_Mutation_p.A927T	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	927					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCATCTTCAGCTCTCTCTGTC	0.468000													68	196					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861572	14861572	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:14861572A>T	ENST00000285046.5	+	1	1104	c.994A>T	c.(994-996)Aat>Tat	p.N332Y	FGD5_ENST00000543601.1_Missense_Mutation_p.N91Y	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	332					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCCTTTTGAGAATGACTGCAT	0.547000													156	28					0	0	1	0	0
CCSER2	54462	broad.mit.edu	37	10	86132112	86132112	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr10:86132112C>T	ENST00000224756.8	+	2	1489	c.1304C>T	c.(1303-1305)tCt>tTt	p.S435F	CCSER2_ENST00000359979.4_Missense_Mutation_p.S435F|CCSER2_ENST00000372088.2_Missense_Mutation_p.S435F	NM_018999.2	NP_061872.2			coiled-coil serine-rich protein 2																		GAGGAAATGTCTCTCAAAGAA	0.348000													55	64					0	0	1	0	0
TRPT1	83707	broad.mit.edu	37	11	63992034	63992034	+	Silent	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:63992034T>C	ENST00000394546.2	-	5	702	c.489A>G	c.(487-489)ggA>ggG	p.G163G	TRPT1_ENST00000546133.1_Silent_p.G35G|TRPT1_ENST00000546089.1_Silent_p.G112G|TRPT1_ENST00000541278.1_Silent_p.G161G|TRPT1_ENST00000394547.3_Silent_p.G112G|TRPT1_ENST00000317459.6_Silent_p.G161G	NM_001033678.3|NM_001160389.1|NM_001160390.1|NM_001160393.1	NP_001028850.2|NP_001153861.1|NP_001153862.1|NP_001153865.1	Q86TN4	TRPT1_HUMAN	tRNA phosphotransferase 1	161							tRNA 2'-phosphotransferase activity			lung(2)|skin(1)	3						TACCGGGGTCTCCAGGCAGTC	0.577000													17	23					0	0	1	0	0
IMPACT	55364	broad.mit.edu	37	18	22017938	22017938	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr18:22017938A>G	ENST00000284202.4	+	5	442	c.301A>G	c.(301-303)Att>Gtt	p.I101V	RP11-178F10.1_ENST00000579049.1_RNA	NM_018439.3	NP_060909.1	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	101	RWD.									endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					CGGTGAAAGTATTCTTTACCT	0.299000													46	47					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26915930	26915930	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:26915930G>C	ENST00000231021.4	-	3	503	c.331C>G	c.(331-333)Cat>Gat	p.H111D		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	111	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTGCAGCATGAATGTCTCCT	0.413000													7	158					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307218	140307218	+	Silent	SNP	C	C	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr5:140307218C>A	ENST00000253807.2	+	1	741	c.741C>A	c.(739-741)ccC>ccA	p.P247P	PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHAC1_ENST00000409700.3_Silent_p.P247P|PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACTGCACCCAATGGGACTG	0.532000													15	39					1.3612e-06	1.42465e-06	1	1	0
THAP6	152815	broad.mit.edu	37	4	76442057	76442057	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr4:76442057T>G	ENST00000311638.3	+	3	224	c.156T>G	c.(154-156)atT>atG	p.I52M	THAP6_ENST00000380837.3_Missense_Mutation_p.I52M|THAP6_ENST00000502620.1_Missense_Mutation_p.I11M|THAP6_ENST00000504190.1_Missense_Mutation_p.I11M|THAP6_ENST00000514480.1_Missense_Mutation_p.I52M|THAP6_ENST00000507556.1_Missense_Mutation_p.I52M|THAP6_ENST00000507557.1_Missense_Mutation_p.I11M|THAP6_ENST00000508105.1_Missense_Mutation_p.I11M|THAP6_ENST00000507885.1_Missense_Mutation_p.I11M	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	52						microtubule cytoskeleton	DNA binding|metal ion binding			lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CAGCCGGCATTTGGGAGCCTA	0.363000													27	90					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256784	16256784	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr1:16256784G>A	ENST00000375759.3	+	11	4253	c.4049G>A	c.(4048-4050)aGa>aAa	p.R1350K		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1350					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GATGCTGGCAGATTTGATGTG	0.418000													24	49					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100962998	100962998	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr3:100962998G>A	ENST00000193391.7	-	13	2364	c.2177C>T	c.(2176-2178)tCt>tTt	p.S726F		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	726					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GATTGCTACAGATGTCAGTAT	0.433000													35	70					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120181725	120181725	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:120181725G>A	ENST00000328078.1	+	1	264	c.187G>A	c.(187-189)Gac>Aac	p.D63N		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	63					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCGCGAGGACGACCCCAACTT	0.692000													61	18					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62259277	62259277	+	Silent	SNP	T	T	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr11:62259277T>C	ENST00000257247.7	-	5	604	c.369A>G	c.(367-369)gaA>gaG	p.E123E	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000525875.1_5'UTR	NM_024060.2	NP_076965.2	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	0					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGTCTTTGCATTCCAGTGCTG	0.468000													7	14					0	0	1	0	0
LHX6	26468	broad.mit.edu	37	9	124991011	124991011	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr9:124991011delC	ENST00000394319.4	-	1	113	c.9delG	c.(7-9)tgfs	p.W3fs	LHX6_ENST00000340587.3_Frame_Shift_Del_p.W3fs|LHX6_ENST00000559529.1_5'UTR	NM_014368.4	NP_055183.2	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	0					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						TCTCATGCTTCCAGTACATGG	0.751													2	4	---	---	---	---					
ORMDL2	29095	broad.mit.edu	37	12	56212928	56212928	+	Frame_Shift_Del	DEL	T	T	-			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr12:56212928delT	ENST00000243045.5	+	2	340	c.145delT	c.(145-147)ggfs	p.W49fs	ORMDL2_ENST00000548974.1_Frame_Shift_Del_p.W49fs|RP11-762I7.5_ENST00000546837.1_Intron|ORMDL2_ENST00000552672.1_Frame_Shift_Del_p.W15fs|RP11-762I7.5_ENST00000552719.1_Intron|ORMDL2_ENST00000550836.1_Intron	NM_014182.4	NP_054901.1	Q53FV1	ORML2_HUMAN	ORM1-like 2 (S. cerevisiae)	49					ceramide metabolic process	endoplasmic reticulum membrane|integral to membrane				kidney(1)|lung(3)	4						TCCTGTTGTCTGGACCCTGAC	0.488													47	62	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546877	3546878	+	RNA	INS	-	-	C			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:3546877_3546878insC	ENST00000574423.2	+	0	111																											tcttttcttttttttttttttt	0.391													2	4	---	---	---	---					
FBXL19	54620	broad.mit.edu	37	16	30939204	30939204	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr16:30939204delC	ENST00000338343.4	+	5	934	c.547delC	c.(547-549)ccfs	p.P185fs	FBXL19_ENST00000471231.2_5'UTR|FBXL19_ENST00000380310.2_Frame_Shift_Del_p.P205fs|FBXL19_ENST00000565690.1_Intron|FBXL19_ENST00000562319.1_Frame_Shift_Del_p.P185fs			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	205							DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						GCCTGCCGGGCCCCCCCCGGA	0.711													2	4	---	---	---	---					
KLC3	147700	broad.mit.edu	37	19	45851393	45851394	+	Frame_Shift_Ins	INS	-	-	T			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr19:45851393_45851394insT	ENST00000470402.1	+	4	896_897	c.796_797insT	c.(796-798)caafs	p.Q266fs	KLC3_ENST00000391946.2_Frame_Shift_Ins_p.Q252fs|KLC3_ENST00000585434.1_Frame_Shift_Ins_p.Q251fs			Q6P597	KLC3_HUMAN	kinesin light chain 3	252						cytoplasm|kinesin complex|microtubule	microtubule motor activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GGCCACCATGCTCAACATCCTG	0.683													11	10	---	---	---	---					
ANKRD20A11P	391267	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													8	211	---	---	---	---					
NAP1L2	4674	broad.mit.edu	37	X	72433664	72433666	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:72433664_72433666delTCC	ENST00000373517.3	-	1	1018_1020	c.663_665delGGA	c.(661-666)gac>ga	p.ED221del	NAP1L2_ENST00000536638.1_In_Frame_Del_p.ED79del	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	221	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CTCAATGTCGtcctcctcctcct	0.424													7	53	---	---	---	---					
SLC6A14	11254	broad.mit.edu	37	X	115574951	115574951	+	Frame_Shift_Del	DEL	T	T	-			TCGA-UF-A71E-01A-31D-A34J-08	TCGA-UF-A71E-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea5270a7-5d42-45eb-908f-601fe20a6b64	5395fbc0-613d-4058-8147-dba0db379899	g.chrX:115574951delT	ENST00000371900.4	+	5	737	c.649delT	c.(649-651)atfs	p.Y217fs		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	217					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CAGTGAACAATATTGGAAGTA	0.338													23	47	---	---	---	---