Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LRP1B	53353	broad.mit.edu	37	2	141473613	141473613	+	Silent	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:141473613A>G	ENST00000389484.3	-	37	6923	c.5952T>C	c.(5950-5952)ggT>ggC	p.G1984G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1984					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AACGGAAAGAACCATTGAGTC	0.348000										TSP Lung(27;0.18)			19	76					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274170	39274170	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:39274170G>T	ENST00000391413.2	-	1	436	c.398C>A	c.(397-399)aCc>aAc	p.T133N		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	133	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gtggcagcaggtgggctggca	0.672000													5	49					0.217242	0.217683	1	1	0
CHURC1	91612	broad.mit.edu	37	14	65392796	65392796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:65392796C>T	ENST00000607599.1	+	3	382	c.328C>T	c.(328-330)Cag>Tag	p.Q110*	CHURC1_ENST00000549115.1_Nonsense_Mutation_p.Q109*|CHURC1-FNTB_ENST00000447296.2_Nonsense_Mutation_p.Q82*|CHURC1_ENST00000548752.2_Intron|CHURC1_ENST00000552002.2_Nonsense_Mutation_p.Q82*|CHURC1_ENST00000359118.2_Nonsense_Mutation_p.Q83*|CHURC1-FNTB_ENST00000542227.1_Intron	NM_001204063.1|NM_145165.3	NP_001190992.1|NP_660148.3			churchill domain containing 1											breast(1)|pancreas(1)	2				all cancers(60;0.00119)|OV - Ovarian serous cystadenocarcinoma(108;0.0056)|BRCA - Breast invasive adenocarcinoma(234;0.00976)		GGATGAATTTCAGGTAAATAT	0.313000													5	105					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47697612	47697612	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:47697612G>A	ENST00000455779.1	+	25	2467	c.2282G>A	c.(2281-2283)aGa>aAa	p.R761K	PHKB_ENST00000566044.1_Missense_Mutation_p.R761K|PHKB_ENST00000299167.8_Missense_Mutation_p.R768K|PHKB_ENST00000323584.5_Missense_Mutation_p.R768K			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	768					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				CACATTGAGAGAGTCTATAGA	0.318000													9	80					0	0	1	0	0
CHCHD1	118487	broad.mit.edu	37	10	75542900	75542900	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:75542900G>C	ENST00000372833.5	+	3	325	c.312G>C	c.(310-312)ttG>ttC	p.L104F	CHCHD1_ENST00000372837.3_3'UTR	NM_203298.2	NP_976043.1	Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 1	104						nucleus				breast(1)	1	Prostate(51;0.0112)					CAAATAAATTGAATAAGTTGT	0.378000													20	40					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31500306	31500306	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:31500306C>A	ENST00000330498.3	+	11	1405	c.1386C>A	c.(1384-1386)taC>taA	p.Y462*		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	462					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						TCTCTAGCTACCTGGCACCGC	0.667000													17	33					2.5808e-16	2.87791e-16	1	1	0
KSR2	283455	broad.mit.edu	37	12	118020146	118020146	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:118020146C>A	ENST00000425217.1	-	6	1157	c.1103G>T	c.(1102-1104)cGc>cTc	p.R368L	KSR2_ENST00000339824.5_Missense_Mutation_p.R397L|KSR2_ENST00000302438.5_Missense_Mutation_p.R94L|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	397					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity	p.R429L(2)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGGGACCAGCGTGGCACTGA	0.577000													27	97					3.90053e-15	4.31065e-15	1	1	0
CPSF7	79869	broad.mit.edu	37	11	61196668	61196668	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:61196668C>T	ENST00000340437.4	-	2	249	c.169G>A	c.(169-171)Gag>Aag	p.E57K	CPSF7_ENST00000439958.3_Missense_Mutation_p.E14K|CPSF7_ENST00000541963.1_Missense_Mutation_p.E14K|CPSF7_ENST00000448745.1_Missense_Mutation_p.E14K|CPSF7_ENST00000394888.4_Missense_Mutation_p.E14K	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	14					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding	p.E14Q(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						TTGAACTCCTCGTCAGCATAT	0.488000													5	119					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834277	178834277	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:178834277G>A	ENST00000234816.2	-	3	1082	c.635C>T	c.(634-636)tCt>tTt	p.S212F	RALGPS2_ENST00000324778.4_Intron|RALGPS2_ENST00000367634.2_Intron|RALGPS2_ENST00000367635.3_Intron|ANGPTL1_ENST00000367629.1_Missense_Mutation_p.S212F	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	212						extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						AAGTGGGGGAGACACATGGGT	0.468000													16	111					0	0	1	0	0
DSCR3	10311	broad.mit.edu	37	21	38600577	38600577	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:38600577G>A	ENST00000309117.6	-	6	842	c.605C>T	c.(604-606)tCg>tTg	p.S202L	DSCR3_ENST00000398998.1_Missense_Mutation_p.S154L|AP001432.14_ENST00000440629.1_lincRNA|DSCR3_ENST00000399000.3_5'UTR|DSCR3_ENST00000288304.5_Silent_p.L159L|DSCR3_ENST00000399001.1_Missense_Mutation_p.S77L|DSCR3_ENST00000539844.1_Missense_Mutation_p.S125L|DSCR3_ENST00000476950.1_Missense_Mutation_p.S175L	NM_006052.1	NP_006043.1	O14972	DSCR3_HUMAN	Down syndrome critical region gene 3	202					vacuolar transport	nucleus|retromer complex				endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9						GGCGGCTTCCGAGCTCTCCAC	0.602000													8	49					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43155769	43155769	+	RNA	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:43155769T>C	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GTTTGGAAGGTATAGTTATTT	0.299000													15	56					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12909106	12909106	+	Silent	SNP	G	G	C	rs138869157		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:12909106G>C	ENST00000338034.4	-	10	1073	c.834C>G	c.(832-834)gtC>gtG	p.V278V	ELAC2_ENST00000395962.2_Silent_p.V259V|ELAC2_ENST00000426905.3_Silent_p.V238V	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	278					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						TCCCGTCCTTGACAGCAGCAA	0.498000													12	77					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58806451	58806451	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:58806451A>G	ENST00000196548.5	+	4	1408	c.1277A>G	c.(1276-1278)gAg>gGg	p.E426G	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		AAGCCCTTTGAGTGCCGCCAG	0.602000													23	104					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54395005	54395005	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:54395005G>A	ENST00000263431.3	+	6	889	c.607G>A	c.(607-609)Gac>Aac	p.D203N	PRKCG_ENST00000540413.1_Missense_Mutation_p.D203N|PRKCG_ENST00000542049.1_Missense_Mutation_p.D90N|PRKCG_ENST00000536044.1_Missense_Mutation_p.D203N	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	203	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding	p.D203H(1)		large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GCTCATCCCAGACCCTCGGAA	0.527000													4	129					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242683097	242683097	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:242683097G>A	ENST00000321264.4	+	5	760	c.551G>A	c.(550-552)cGg>cAg	p.R184Q	D2HGDH_ENST00000403782.1_Missense_Mutation_p.R50Q|D2HGDH_ENST00000537090.1_Missense_Mutation_p.R184Q|D2HGDH_ENST00000342518.6_Missense_Mutation_p.R184Q	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	184	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GTGGAGGAACGGGACTTCATC	0.612000													12	24					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516722	140516722	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140516722C>A	ENST00000231134.5	+	1	1923	c.1706C>A	c.(1705-1707)gCg>gAg	p.A569E		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		569	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACGGCTCGGCGCCTTGCACC	0.721000													13	55					1.52009e-12	1.67617e-12	1	1	0
LILRA2	11027	broad.mit.edu	37	19	55086487	55086487	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:55086487G>A	ENST00000251377.3	+	5	775	c.642G>A	c.(640-642)gaG>gaA	p.E214E	LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Silent_p.E214E|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Silent_p.E202E|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391738.3_Silent_p.E214E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ATCTCCTGGAGCTCCTGGTCC	0.597000													10	134					0	0	1	0	0
ACADVL	37	broad.mit.edu	37	17	7128306	7128306	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:7128306G>A	ENST00000356839.5	+	20	2037	c.1858G>A	c.(1858-1860)Gcc>Acc	p.A620T	ACADVL_ENST00000543245.2_Missense_Mutation_p.A643T|ACADVL_ENST00000350303.5_Missense_Mutation_p.A598T	NM_000018.3|NM_001270448.1	NP_000009.1|NP_001257377.1	P49748	ACADV_HUMAN	acyl-CoA dehydrogenase, very long chain	620					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(1)|ovary(4)|skin(1)	21						GGGCATGGCCGCCCTGCAGTC	0.647000													11	42					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14543009	14543009	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr18:14543009G>A	ENST00000358970.5	-	1	136	c.137C>T	c.(136-138)tCt>tTt	p.S46F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	46										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GTGGTCTCCAGAAGTGCCCAT	0.582000													7	358					0	0	1	0	0
RUNX1	861	broad.mit.edu	37	21	36206728	36206728	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:36206728G>C	ENST00000344691.4	-	4	2280	c.703C>G	c.(703-705)Cag>Gag	p.Q235E	RUNX1_ENST00000300305.3_Missense_Mutation_p.Q262E|RUNX1_ENST00000358356.5_Missense_Mutation_p.Q235E|RUNX1_ENST00000399240.1_Intron|RUNX1_ENST00000437180.1_Missense_Mutation_p.Q262E|RUNX1_ENST00000325074.5_Missense_Mutation_p.Q250E	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	235	Pro/Ser/Thr-rich.				myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.Q262*(1)|p.F259fs*219(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						CTCTGAGGCTGAGGGTTAAAG	0.652000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								18	69					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36499868	36499868	+	Nonsense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:36499868C>G	ENST00000373191.4	+	13	2034	c.1685C>G	c.(1684-1686)tCa>tGa	p.S562*	AGO3_ENST00000246314.6_Nonsense_Mutation_p.S328*	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		CAAACTCTGTCAAACTTGTGC	0.353000													5	34					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9515039	9515039	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:9515039A>G	ENST00000281419.3	+	17	2052	c.1712A>G	c.(1711-1713)gAt>gGt	p.D571G	ASAP2_ENST00000315273.4_Missense_Mutation_p.D571G	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	571					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						GATGGTGTGGATCTTACGGAA	0.483000													23	56					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10425596	10425596	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:10425596C>G	ENST00000377086.1	+	43	4844	c.4642C>G	c.(4642-4644)Cag>Gag	p.Q1548E	KIF1B_ENST00000377081.1_Missense_Mutation_p.Q1548E|KIF1B_ENST00000263934.6_Missense_Mutation_p.Q1502E			O60333	KIF1B_HUMAN	kinesin family member 1B	1548					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TATCTCCTCTCAGATCTCAAC	0.552000													19	66					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72050645	72050645	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:72050645G>A	ENST00000548100.1	-	2	1248	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	ZFC3H1_ENST00000378743.3_Intron|ZFC3H1_ENST00000552037.1_Intron			O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	0					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ATTACTAACTGAAATATTTAA	0.318000													14	62					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933929	49933929	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:49933929G>C	ENST00000221485.3	-	12	1701	c.1530C>G	c.(1528-1530)ttC>ttG	p.F510L	SLC17A7_ENST00000600601.1_Missense_Mutation_p.F443L|SLC17A7_ENST00000543531.1_Missense_Mutation_p.F498L	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	510					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CATGGCCAACGAAGCCACACT	0.627000													12	56					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402809	33402809	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:33402809G>T	ENST00000373456.7	-	9	1796	c.1797C>A	c.(1795-1797)caC>caA	p.H599Q	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Missense_Mutation_p.H598Q	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	599						integral to membrane	ligase activity|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CCAGCTGATAGTGGCTTGGTT	0.483000													16	137					3.45872e-05	3.61228e-05	1	1	0
HDAC10	83933	broad.mit.edu	37	22	50689234	50689234	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr22:50689234C>T	ENST00000216271.5	-	2	512	c.160G>A	c.(160-162)Gag>Aag	p.E54K	HDAC10_ENST00000448072.1_Missense_Mutation_p.E54K|HDAC10_ENST00000349505.4_Missense_Mutation_p.E54K|HDAC10_ENST00000498366.1_5'UTR|MAPK12_ENST00000497036.1_5'UTR	NM_001159286.1|NM_032019.5	NP_001152758.1|NP_114408.3	Q969S8	HDA10_HUMAN	histone deacetylase 10	54	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)			endometrium(2)|kidney(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCGAGGCCTCGCGGGCTGAC	0.706000													3	12					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904309	55904309	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:55904309C>A	ENST00000301529.1	-	1	885	c.886G>T	c.(886-888)Gat>Tat	p.D296Y		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					ACATTTACATCATTATTCCTC	0.348000													19	39					3.73194e-20	4.17099e-20	1	1	0
SMG6	23293	broad.mit.edu	37	17	2201249	2201249	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:2201249G>C	ENST00000544865.1	-	3	2365	c.1855C>G	c.(1855-1857)Cag>Gag	p.Q619E	SMG6_ENST00000263073.5_Missense_Mutation_p.Q650E			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	650					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TCAATCACCTGATAGAAAGCA	0.423000													18	84					0	0	1	0	0
ZNF529	57711	broad.mit.edu	37	19	37038219	37038219	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:37038219C>T	ENST00000334116.7	-	6	1536	c.926G>A	c.(925-927)aGg>aAg	p.R309K	ZNF529_ENST00000591340.1_Missense_Mutation_p.R414K	NM_001145650.1	NP_001139122.1	Q6P280	ZN529_HUMAN	zinc finger protein 529	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AGTATGAATCCTCTGATGTCT	0.383000													20	130					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175375816	175375816	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:175375816T>G	ENST00000367674.1	-	3	743	c.35A>C	c.(34-36)aAc>aCc	p.N12T	TNR_ENST00000263525.2_Missense_Mutation_p.N12T	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	12					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AATGAGCATGTTCTTCAGAAC	0.542000													48	100					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76452507	76452507	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:76452507G>A	ENST00000388942.3	+	5	730	c.454G>A	c.(454-456)Gag>Aag	p.E152K		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	152						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						GTTCTTCTCAGAGGTAGGTGG	0.512000													19	116					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113933538	113933538	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:113933538G>C	ENST00000348367.4	-	7	676	c.479C>G	c.(478-480)tCa>tGa	p.S160*	GPAM_ENST00000423155.1_Nonsense_Mutation_p.S160*|GPAM_ENST00000369425.1_Nonsense_Mutation_p.S160*			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	160					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		AACGGCTTTTGATTGCTGCTG	0.413000													7	45					0	0	1	0	0
ZNF442	79973	broad.mit.edu	37	19	12461186	12461186	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:12461186G>A	ENST00000242804.4	-	6	1795	c.1213C>T	c.(1213-1215)Cac>Tac	p.H405Y	ZNF442_ENST00000438182.1_Missense_Mutation_p.H336Y	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						TTGCATTTGTGAGGTCCATCT	0.423000													20	137					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1153085	1153085	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:1153085C>T	ENST00000263741.7	-	7	1304	c.1012G>A	c.(1012-1014)Gcc>Acc	p.A338T	SDF4_ENST00000360001.6_Intron	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	0	EF-hand 6.|Necessary for intracellular retention in Golgi apparatus lumen (By similarity).				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GCGAGCGGGGCACAGGTCAGC	0.637000													8	77					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644521	169644521	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:169644521C>T	ENST00000428432.2	+	6	860	c.471C>T	c.(469-471)ctC>ctT	p.L157L	SAMD7_ENST00000335556.3_Silent_p.L157L	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	157										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAAGCACCCTCAGAAACCTTC	0.572000													9	118					0	0	1	0	0
HMG20B	10362	broad.mit.edu	37	19	3576258	3576258	+	Splice_Site	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:3576258G>A	ENST00000333651.6	+	6	547		c.e6-1			NM_006339.2	NP_006330.2	Q9P0W2	HM20B_HUMAN	high mobility group 20B						blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity	p.?(1)		cervix(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCCGCCAGAAGACTCGAG	0.627000													13	62					0	0	1	0	0
LRRC73	221424	broad.mit.edu	37	6	43474984	43474984	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:43474984C>G	ENST00000372441.1	-	6	1843	c.943G>C	c.(943-945)Gag>Cag	p.E315Q		NM_001012974.1	NP_001012992.1	Q5JTD7	CF154_HUMAN	leucine rich repeat containing 73	315																	AGTCACATCTCGGTCTCAGCC	0.557000											OREG0017453	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	33					0	0	1	0	0
TRIM52	84851	broad.mit.edu	37	5	180687775	180687775	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:180687775G>A	ENST00000327767.4	-	1	344	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	TRIM52_ENST00000514805.1_5'UTR|CTC-338M12.4_ENST00000511331.1_RNA	NM_032765.2	NP_116154.1	Q96A61	TRI52_HUMAN	tripartite motif containing 52	14						intracellular	zinc ion binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		TCCTCCTGAAGGGTCTGCATG	0.597000													7	43					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118484405	118484405	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:118484405C>G	ENST00000349139.4	+	9	971	c.924C>G	c.(922-924)atC>atG	p.I308M	WDR3_ENST00000369441.3_3'UTR	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	308						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TGTTTTGTATCCTTTCCAAAA	0.303000													6	30					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176539	142176539	+	RNA	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:142176539G>A	ENST00000390369.2	-	0	136																											TACATGACCCGAAATTGAATC	0.527000													11	54					0	0	1	0	0
HNRNPU	3192	broad.mit.edu	37	1	245021528	245021528	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:245021528C>G	ENST00000444376.2	-	7	1456	c.1222G>C	c.(1222-1224)Gat>Cat	p.D408H	HNRNPU_ENST00000283179.9_Missense_Mutation_p.D427H	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	427	B30.2/SPRY.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding	p.N405_K417delNGQDLGVAFKISK(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			ACGCCAAGATCTTGTCCATTC	0.393000													11	52					0	0	1	0	0
FABP9	646480	broad.mit.edu	37	8	82373744	82373744	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:82373744G>T	ENST00000379071.2	-	1	70	c.15C>A	c.(13-15)ttC>ttA	p.F5L	RP11-157I4.4_ENST00000524085.2_RNA	NM_001080526.1	NP_001073995.1	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	5							lipid binding|transporter activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6			Epithelial(68;0.186)			AGGTTCCCAAGAAGGGCTCAA	0.398000													15	115					0.00400662	0.00409787	1	1	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													3	35					0	0	1	0	0
MFN2	9927	broad.mit.edu	37	1	12061511	12061511	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:12061511C>T	ENST00000235329.5	+	9	1192	c.870C>T	c.(868-870)ggC>ggT	p.G290G	MFN2_ENST00000444836.1_Silent_p.G290G	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	290					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		ATGAGCTGGGCGTGGTGGATC	0.597000													3	25					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49261419	49261419	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:49261419C>T	ENST00000593756.1	+	4	1144	c.572C>T	c.(571-573)tCg>tTg	p.S191L	FGF21_ENST00000222157.3_Missense_Mutation_p.S191L			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	191					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		GTGGGCTCCTCGGACCCTCTG	0.637000													4	25					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47690425	47690425	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:47690425G>C	ENST00000525123.1	-	15	2467	c.2182C>G	c.(2182-2184)Ctt>Gtt	p.L728V	AGBL2_ENST00000357610.3_Missense_Mutation_p.L730V|AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000298861.4_Missense_Mutation_p.L728V|AGBL2_ENST00000528244.1_Missense_Mutation_p.L690V	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	728					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						TGAACAGGAAGACCATCTGAG	0.388000													6	68					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134049	119134049	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:119134049G>A	ENST00000264245.4	+	12	3805	c.3273G>A	c.(3271-3273)aaG>aaA	p.K1091K		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1091					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						TACAGCTAAAGAGCACAGAGT	0.562000													26	204					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124058634	124058634	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:124058634T>G	ENST00000368994.2	+	9	1030	c.779T>G	c.(778-780)gTg>gGg	p.V260G	BTBD16_ENST00000260723.4_Missense_Mutation_p.V259G			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	259										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CTCCACAAAGTGCTGAAGTCC	0.622000											OREG0020592	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	22					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114298149	114298149	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:114298149C>G	ENST00000408937.3	+	12	1744	c.1370C>G	c.(1369-1371)tCg>tGg	p.S457W	FOXP2_ENST00000393494.2_Missense_Mutation_p.S432W|FOXP2_ENST00000393489.3_Missense_Mutation_p.S340W|FOXP2_ENST00000393500.3_3'UTR|FOXP2_ENST00000350908.4_Missense_Mutation_p.S432W|FOXP2_ENST00000403559.4_Missense_Mutation_p.S449W|FOXP2_ENST00000393498.2_Missense_Mutation_p.S411W|FOXP2_ENST00000393491.3_Intron	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	432					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GTCACCATGTCGAAGAATATG	0.483000													12	65					0	0	1	0	0
CCDC15	80071	broad.mit.edu	37	11	124861477	124861477	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:124861477C>T	ENST00000529051.1	+	9	2288	c.2029C>T	c.(2029-2031)Cag>Tag	p.Q677*	CCDC15_ENST00000344762.5_Nonsense_Mutation_p.Q677*			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	677						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATCAAAAATCAGGTAGAGTA	0.398000													3	7					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64168348	64168348	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:64168348G>C	ENST00000395391.1	+	4	3041	c.1666G>C	c.(1666-1668)Gaa>Caa	p.E556Q	ZNF107_ENST00000344930.3_Missense_Mutation_p.E556Q|ZNF107_ENST00000423627.1_Missense_Mutation_p.E556Q			Q9UII5	ZN107_HUMAN	zinc finger protein 107	556					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CAAATGTGAAGAACATGGCAA	0.353000													10	57					0	0	1	0	0
DENND2D	79961	broad.mit.edu	37	1	111730772	111730772	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:111730772C>G	ENST00000357640.4	-	11	1549	c.1320G>C	c.(1318-1320)aaG>aaC	p.K440N	DENND2D_ENST00000369752.5_Missense_Mutation_p.K437N	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	440										breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GATTCTTGCTCTTCTCGGCTT	0.468000													7	40					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132306116	132306116	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:132306116C>T	ENST00000331898.7	-	6	1379	c.801G>A	c.(799-801)ctG>ctA	p.L267L	OPCML_ENST00000374778.4_Silent_p.L226L|OPCML_ENST00000524381.1_Silent_p.L260L|OPCML_ENST00000541867.1_Silent_p.L267L|OPCML_ENST00000529038.1_5'UTR	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	267	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCATTCCATCCAGACCAGTGG	0.443000													12	52					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42126602	42126602	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr22:42126602G>C	ENST00000401548.3	+	9	1097	c.1057G>C	c.(1057-1059)Gaa>Caa	p.E353Q	MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_Missense_Mutation_p.E93Q	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	353							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						ACTCCTGGTAGAAGAGCCACT	0.488000													8	42					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112860722	112860722	+	Nonsense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:112860722C>G	ENST00000161863.4	+	3	536	c.323C>G	c.(322-324)tCa>tGa	p.S108*	YTHDC2_ENST00000515883.1_Nonsense_Mutation_p.S108*	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	108							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AAAGATGGATCAGAAACAGCT	0.323000													5	33					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50247582	50247582	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:50247582C>G	ENST00000246801.3	-	8	1349	c.1267G>C	c.(1267-1269)Gag>Cag	p.E423Q	TSKS_ENST00000358830.3_Missense_Mutation_p.E223Q	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	423							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CGCCCGAACTCCTCCAGAATG	0.597000													7	47					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	897555	897555	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:897555G>C	ENST00000456758.2	+	19	2052	c.2052G>C	c.(2050-2052)gtG>gtC	p.V684V	SUN1_ENST00000413514.2_Silent_p.V293V|SUN1_ENST00000405266.1_Silent_p.V532V|SUN1_ENST00000425407.2_Silent_p.V412V|SUN1_ENST00000401592.1_Silent_p.V495V|SUN1_ENST00000452783.2_Silent_p.V392V|SUN1_ENST00000389574.3_Silent_p.V412V			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	522	SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGCGACACGTGAAGACCGGCT	0.483000													24	243					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514434	99514434	+	Silent	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:99514434C>A	ENST00000261037.3	+	5	2069	c.1689C>A	c.(1687-1689)ggC>ggA	p.G563G	COL8A1_ENST00000273342.4_Silent_p.G563G	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	563	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						gacccccaggccctccaggac	0.637000													14	34					0.000151284	0.000156022	1	1	0
SOS2	6655	broad.mit.edu	37	14	50605458	50605458	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:50605458C>G	ENST00000216373.5	-	18	3104	c.2830G>C	c.(2830-2832)Gat>Cat	p.D944H	SOS2_ENST00000543680.1_Missense_Mutation_p.D911H	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	944	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTTAAAAAATCATTATTCCCT	0.249000													4	23					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17810491	17810491	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:17810491C>T	ENST00000325083.8	+	9	1523	c.1084C>T	c.(1084-1086)Cca>Tca	p.P362S	PCM1_ENST00000518537.1_Missense_Mutation_p.P401S|PCM1_ENST00000519253.1_Missense_Mutation_p.P362S|PCM1_ENST00000524226.1_Missense_Mutation_p.P362S	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	362					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		TCCAGCTGTTCCAGACAATAG	0.343000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								3	9					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130332600	130332600	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:130332600T>A	ENST00000299164.2	+	4	1467	c.1467T>A	c.(1465-1467)gaT>gaA	p.D489E		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	489	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCTGGGCCGATGGCACCAGCT	0.627000													7	90					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733114	152733114	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:152733114C>T	ENST00000368773.1	+	2	1108	c.1050C>T	c.(1048-1050)atC>atT	p.I350I	KPRP_ENST00000606109.1_Silent_p.I350I	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	350	Pro-rich.					cytoplasm		p.I350M(2)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCCATCAGACGCCGCT	0.652000													7	41					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269842	1269842	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:1269842G>A	ENST00000447027.1	+	31	11799	c.11741G>A	c.(11740-11742)gGg>gAg	p.G3914E	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.G3911E			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3911	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCGTCCCGGGGACCACCCAC	0.642000													5	73					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116066899	116066899	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:116066899A>G	ENST00000410059.1	+	2	625	c.145A>G	c.(145-147)Atc>Gtc	p.I49V	DPP10_ENST00000310323.8_Missense_Mutation_p.I42V|DPP10_ENST00000393147.2_Missense_Mutation_p.I53V|DPP10_ENST00000409163.1_5'UTR	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	49	Mediates effects on KCND2.				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						ATGCTCACTCATCACTATGTC	0.413000													8	53					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44377562	44377562	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:44377562C>G	ENST00000587539.1	-	3	803	c.804G>C	c.(802-804)gtG>gtC	p.V268V	ZNF404_ENST00000324394.6_Silent_p.V266V	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				TGTAGGGTTTCACACCATGAT	0.353000													6	37					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34903824	34903824	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:34903824C>T	ENST00000381831.3	-	6	831	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	GART_ENST00000361093.5_Missense_Mutation_p.E190K|GART_ENST00000497313.1_5'UTR|GART_ENST00000381839.3_Missense_Mutation_p.E190K|GART_ENST00000381815.4_Missense_Mutation_p.E190K	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	190	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding	p.E190*(1)		NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	AGAAGTTCTTCAATGACAATT	0.353000													20	136					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140301918	140301918	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:140301918C>T	ENST00000275884.6	-	2	697	c.280G>A	c.(280-282)Gag>Aag	p.E94K	DENND2A_ENST00000496613.1_Missense_Mutation_p.E94K|DENND2A_ENST00000492720.1_Missense_Mutation_p.E94K|DENND2A_ENST00000537639.1_Missense_Mutation_p.E94K			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	94										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TTCTTAGCCTCTGTGACCTGA	0.572000													20	98					0	0	1	0	0
ACADVL	37	broad.mit.edu	37	17	7124970	7124970	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:7124970G>C	ENST00000356839.5	+	7	770	c.591G>C	c.(589-591)caG>caC	p.Q197H	ACADVL_ENST00000543245.2_Missense_Mutation_p.Q220H|ACADVL_ENST00000350303.5_Missense_Mutation_p.Q175H|ACADVL_ENST00000581562.1_Intron	NM_000018.3|NM_001270448.1	NP_000009.1|NP_001257377.1	P49748	ACADV_HUMAN	acyl-CoA dehydrogenase, very long chain	197	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(1)|ovary(4)|skin(1)	21						CAAAGGCCCAGAAAGAAAAAT	0.577000													10	60					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741740	140741740	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140741740G>A	ENST00000522605.1	+	1	2038	c.2038G>A	c.(2038-2040)Gag>Aag	p.E680K	PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACCGCCGGGAGCCCTCTGA	0.597000													13	74					0	0	1	0	0
OLFML1	283298	broad.mit.edu	37	11	7507148	7507148	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:7507148G>C	ENST00000329293.3	+	1	436	c.42G>C	c.(40-42)ctG>ctC	p.L14L	OLFML1_ENST00000530135.1_Silent_p.L14L|CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000528758.1_Silent_p.L14L	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	14						extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TGCTGGTTCTGTTCCTTGCAG	0.547000													15	77					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137246	40137246	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:40137246C>G	ENST00000278198.2	-	2	2560	c.597G>C	c.(595-597)ttG>ttC	p.L199F	LRRC4C_ENST00000527150.1_Missense_Mutation_p.L199F|LRRC4C_ENST00000530763.1_Missense_Mutation_p.L199F|LRRC4C_ENST00000528697.1_Missense_Mutation_p.L199F			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	199					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAAATACCTCAAGTTGGACA	0.428000													14	103					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126408679	126408679	+	Silent	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:126408679T>C	ENST00000394329.3	+	16	13009	c.12996T>C	c.(12994-12996)acT>acC	p.T4332T	FAT4_ENST00000335110.5_Silent_p.T2573T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4332	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCCACCCTACTCAGGACTTCG	0.423000													13	35					0	0	1	0	0
C21orf91	54149	broad.mit.edu	37	21	19169332	19169332	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:19169332C>G	ENST00000284881.4	-	3	321	c.231G>C	c.(229-231)aaG>aaC	p.K77N	C21orf91_ENST00000493464.1_5'UTR|C21orf91_ENST00000400558.3_Missense_Mutation_p.K77N|AL109761.5_ENST00000428689.1_RNA|C21orf91_ENST00000400559.3_Missense_Mutation_p.K77N	NM_001100420.1|NM_017447.3	NP_001093890.1|NP_059143.3	Q9NYK6	EURL_HUMAN	chromosome 21 open reading frame 91	77										endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		TTTTTGAAAGCTTAGATCGAG	0.358000													13	72					0	0	1	0	0
IGFBP4	3487	broad.mit.edu	37	17	38609380	38609380	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:38609380G>A	ENST00000269593.4	+	2	768	c.493G>A	c.(493-495)Gat>Aat	p.D165N	IGFBP4_ENST00000542955.1_Missense_Mutation_p.D65N	NM_001552.2	NP_001543.2	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	165					DNA metabolic process|signal transduction|skeletal system development					NS(1)|endometrium(1)|kidney(1)|large_intestine(2)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GCCCCGGGAGGATGCCCGGCC	0.612000													5	28					0	0	1	0	0
RAD23A	5886	broad.mit.edu	37	19	13059952	13059952	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:13059952G>C	ENST00000586534.1	+	6	719	c.658G>C	c.(658-660)Gag>Cag	p.E220Q	RAD23A_ENST00000316856.3_Missense_Mutation_p.E220Q|RAD23A_ENST00000541222.1_Missense_Mutation_p.E55Q|RAD23A_ENST00000592268.1_Missense_Mutation_p.E220Q|RAD23A_ENST00000588826.2_3'UTR			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	220					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						CCAGGTATCGGAGCAGCCGGC	0.612000								Nucleotide excision repair (NER)					3	29					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144810838	144810838	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:144810838C>G	ENST00000388913.3	-	5	918	c.793G>C	c.(793-795)Gag>Cag	p.E265Q		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	265					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAGACCAGCTCTCCTTGGAAC	0.657000													6	47					0	0	1	0	0
FANCC	2176	broad.mit.edu	37	9	97869405	97869405	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:97869405G>C	ENST00000289081.3	-	14	1730	c.1476C>G	c.(1474-1476)ctC>ctG	p.L492L	FANCC_ENST00000375305.1_Silent_p.L492L	NM_000136.2	NP_000127.2	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	492					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)|skin(1)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(62;0.138)				GCAGGAAGTTGAGGAGAAGGT	0.587000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				8	46					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22952004	22952004	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:22952004G>A	ENST00000397104.3	-	2	188	c.189C>T	c.(187-189)ttC>ttT	p.F63F	ZNF99_ENST00000596209.1_Silent_p.F42F					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCTCACCCAGGAAGACCAGGT	0.373000													11	105					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127649076	127649076	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:127649076C>G	ENST00000405109.1	+	4	1909	c.1442C>G	c.(1441-1443)tCt>tGt	p.S481C	KBTBD12_ENST00000343941.4_Missense_Mutation_p.S56C|KBTBD12_ENST00000405256.1_Missense_Mutation_p.S481C|KBTBD12_ENST00000492025.1_3'UTR|KBTBD12_ENST00000407609.3_Missense_Mutation_p.S88C			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	481										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						ATGAAGTACTCTAAGTACCGA	0.418000													3	33					0	0	1	0	0
PGBD4	161779	broad.mit.edu	37	15	34395407	34395407	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:34395407G>A	ENST00000397766.2	+	1	1134	c.675G>A	c.(673-675)aaG>aaA	p.K225K		NM_152595.4	NP_689808.2	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	225										breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|pancreas(1)|prostate(1)	16		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		CATTGCAGAAGATCAAACCTG	0.378000													11	62					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55597234	55597234	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:55597234G>C	ENST00000201647.6	+	15	1467	c.1411G>C	c.(1411-1413)Gag>Cag	p.E471Q	EPS8L1_ENST00000586329.1_Missense_Mutation_p.E485Q|EPS8L1_ENST00000540810.1_Missense_Mutation_p.E407Q|EPS8L1_ENST00000245618.5_Missense_Mutation_p.E344Q|EPS8L1_ENST00000588359.1_Missense_Mutation_p.E157Q	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	471						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCCAGAATCTGAGCCTCAGCT	0.582000													11	71					0	0	1	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32522722	32522722	+	RNA	SNP	C	C	A	rs114905475	by1000genomes	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:32522722C>A	ENST00000411500.1	-	0	484					NR_001298.1																						TGGGTCTTTGCAGGATACACA	0.488000													3	17					0.004672	0.00476853	1	1	0
UNC79	57578	broad.mit.edu	37	14	94004426	94004426	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:94004426A>G	ENST00000553484.1	+	12	1368	c.1214A>G	c.(1213-1215)aAg>aGg	p.K405R	UNC79_ENST00000555664.1_Missense_Mutation_p.K405R|UNC79_ENST00000256339.4_Missense_Mutation_p.K228R|UNC79_ENST00000393151.2_Missense_Mutation_p.K405R			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	405						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CGGTACTGCAAGAGGTGCCAC	0.567000													12	61					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197708800	197708800	+	Splice_Site	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:197708800C>T	ENST00000354764.3	-	25	2452		c.e25-1			NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						GTTTGGGATTCTATAAAACAA	0.303000													14	17					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31593070	31593070	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:31593070G>A	ENST00000376033.2	+	6	820	c.586G>A	c.(586-588)Gga>Aga	p.G196R	PRRC2A_ENST00000469577.1_3'UTR|PRRC2A_ENST00000376007.4_Missense_Mutation_p.G196R	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	196	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GTCTGGGCCCGGACCAAGCCT	0.582000													9	61					0	0	1	0	0
EIF2B4	8890	broad.mit.edu	37	2	27587375	27587375	+	Silent	SNP	G	G	T	rs1058076		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:27587375G>T	ENST00000493344.2	-	12	1839	c.1527C>A	c.(1525-1527)gtC>gtA	p.V509V	EIF2B4_ENST00000445933.2_Silent_p.V487V|EIF2B4_ENST00000451130.2_Silent_p.V508V|EIF2B4_ENST00000347454.4_Silent_p.V488V|AC074117.10_ENST00000412749.1_RNA			Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	488					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(5)|skin(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACATCATAGACTAGATTCA	0.517000													13	53					4.36969e-10	4.77572e-10	1	1	0
WNT16	51384	broad.mit.edu	37	7	120978954	120978954	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:120978954C>A	ENST00000222462.2	+	4	943	c.653C>A	c.(652-654)tCa>tAa	p.S218*	WNT16_ENST00000361301.2_Nonsense_Mutation_p.S208*	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	218					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					AAGTTGATGTCAGTAGACTGC	0.413000													8	36					2.17888e-05	2.28044e-05	1	1	0
RPLP0	6175	broad.mit.edu	37	12	120636522	120636522	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:120636522C>G	ENST00000551150.1	-	5	801	c.486G>C	c.(484-486)aaG>aaC	p.K162N	RPLP0_ENST00000313104.5_Intron|RPLP0_ENST00000392514.4_Missense_Mutation_p.K162N|RPLP0_ENST00000546989.1_Intron|RPLP0_ENST00000228306.4_Missense_Mutation_p.K162N			P05388	RLA0_HUMAN	ribosomal protein, large, P0	162					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGTCTCCAGTCTTGATCAGCT	0.522000													12	69					0	0	1	0	0
TRAPPC4	51399	broad.mit.edu	37	11	118889511	118889511	+	Silent	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:118889511G>T	ENST00000533632.1	+	1	370	c.6G>T	c.(4-6)gcG>gcT	p.A2A	TRAPPC4_ENST00000434101.2_Silent_p.A2A|TRAPPC4_ENST00000525303.1_Silent_p.A2A|TRAPPC4_ENST00000533058.1_Silent_p.A2A|TRAPPC4_ENST00000359005.4_Silent_p.A2A|TRAPPC4_ENST00000528230.1_Silent_p.A2A	NM_016146.4	NP_057230.1	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	2					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		CAGCGATGGCGATTTTTAGTG	0.592000													39	123					7.53189e-24	8.45626e-24	1	1	0
HMMR	3161	broad.mit.edu	37	5	162911099	162911099	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:162911099G>C	ENST00000416990.2	+	16	1962	c.1465G>C	c.(1465-1467)Gaa>Caa	p.E489Q	HMMR_ENST00000393915.4_Missense_Mutation_p.E604Q|HMMR_ENST00000358715.3_Missense_Mutation_p.E603Q|RP11-80G7.1_ENST00000514724.2_RNA|RP11-80G7.1_ENST00000521666.1_RNA|HMMR_ENST00000353866.3_Missense_Mutation_p.E588Q|HMMR_ENST00000432118.2_Missense_Mutation_p.E517Q			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	603						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TTTTGAAGTAGAAAAACAGGC	0.294000													8	42					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3844845	3844845	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:3844845C>T	ENST00000309890.7	-	13	1799	c.1649G>A	c.(1648-1650)cGg>cAg	p.R550Q	ATP2A3_ENST00000352011.3_Missense_Mutation_p.R550Q|ATP2A3_ENST00000397043.3_Missense_Mutation_p.R550Q|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000359983.3_Missense_Mutation_p.R550Q|ATP2A3_ENST00000397035.3_Missense_Mutation_p.R550Q|ATP2A3_ENST00000397041.3_Missense_Mutation_p.R550Q	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	550					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GCCCCAATCCCGGATCTTTGC	0.667000													16	64					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145659007	145659007	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:145659007G>C	ENST00000409379.3	-	22	3552	c.3523C>G	c.(3523-3525)Ctg>Gtg	p.L1175V		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	1175					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						TGGTGGCTCAGAAAGAAGCTG	0.647000													13	100					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39798523	39798523	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:39798523G>A	ENST00000564288.1	+	37	7040	c.6263G>A	c.(6262-6264)aGa>aAa	p.R2088K	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.R2125K|MACF1_ENST00000289893.4_Missense_Mutation_p.R528K|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.R2093K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2093					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAAAAGAGAGAAATCCAAAC	0.378000													7	41					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70338481	70338481	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:70338481G>A	ENST00000338508.4	-	29	2400	c.2401C>T	c.(2401-2403)Cgg>Tgg	p.R801W	SHANK2_ENST00000449833.2_Missense_Mutation_p.R205W|SHANK2_ENST00000357171.3_Missense_Mutation_p.R212W|SHANK2_ENST00000449116.2_Missense_Mutation_p.R202W|SHANK2_ENST00000423696.2_Missense_Mutation_p.R421W|SHANK2_ENST00000409530.1_Missense_Mutation_p.R211W|SHANK2_ENST00000409161.1_Missense_Mutation_p.R204W			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	421					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTGCTGGGCCGCTGCTTGATG	0.652000													7	204					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	14133	14133	+	Silent	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrM:14133A>G	ENST00000361567.2	+	1	1797	c.1797A>G	c.(1795-1797)ctA>ctG	p.L599L				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	599					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	ATCCTAACCCTACTCCTAATC	0.398000													13	2					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183665224	183665224	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:183665224C>T	ENST00000334444.6	-	23	3542	c.3302G>A	c.(3301-3303)cGg>cAg	p.R1101Q	ABCC5_ENST00000265586.6_Missense_Mutation_p.R1058Q	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1101	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAGGTCCAGCCGCACAGCCAG	0.547000													3	44					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76350415	76350415	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:76350415G>C	ENST00000307431.8	+	3	573	c.188G>C	c.(187-189)aGa>aCa	p.R63T	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.R39T|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.R67T|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.R63T	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	64	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CTGAATAGAAGAGATGGTAAG	0.433000													7	15					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54445537	54445537	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:54445537C>A	ENST00000391767.1	+	6	1030	c.818C>A	c.(817-819)tCg>tAg	p.S273*	CACNG7_ENST00000222212.2_Nonsense_Mutation_p.S273*			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	273				GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		ATCTCCACCTCGCCCTGCTGA	0.672000													54	139					1.27862e-28	1.43881e-28	1	1	0
PLCD1	5333	broad.mit.edu	37	3	38051768	38051768	+	Splice_Site	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:38051768T>G	ENST00000463876.1	-	7	1409		c.e7-2		PLCD1_ENST00000334661.4_Splice_Site	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1						intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CACAGTGCCCTGCGGGGAGGG	0.617000													11	63					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	440874	440874	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:440874G>A	ENST00000264554.6	-	2	526	c.527C>T	c.(526-528)aCg>aTg	p.T176M		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	176	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCACCTGCGTGCGCGTGTT	0.652000													31	108					0	0	1	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600561	3600561	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:3600561C>T	ENST00000375190.4	-	2	465	c.72G>A	c.(70-72)ctG>ctA	p.L24L	TBXA2R_ENST00000411851.3_Silent_p.L24L|TBXA2R_ENST00000589966.1_Silent_p.L24L	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	24					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	GCGAGGCGATCAGCCGTCTCT	0.697000													5	36					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196210645	196210645	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:196210645G>C	ENST00000318037.3	-	4	1270	c.676C>G	c.(676-678)Cag>Gag	p.Q226E		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	226					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		ACTTACTTCTGAATATCTCCA	0.368000													18	124					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121209049	121209049	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:121209049G>A	ENST00000264233.5	-	16	2857	c.2729C>T	c.(2728-2730)tCa>tTa	p.S910L		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	910					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ATGAGTCAATGAGCATGTACT	0.373000								DNA polymerases (catalytic subunits)					21	98					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109201498	109201498	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:109201498G>A	ENST00000326495.5	-	8	735	c.642C>T	c.(640-642)atC>atT	p.I214I	SSH1_ENST00000326470.5_Silent_p.I225I|SSH1_ENST00000551165.1_Silent_p.I214I|SSH1_ENST00000360239.3_5'UTR	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	214					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCTCGGAGCTGATGCAGCTCT	0.602000													11	80					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74420205	74420205	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:74420205G>A	ENST00000238709.4	+	2	309	c.65G>A	c.(64-66)aGa>aAa	p.R22K	COQ6_ENST00000394026.4_Silent_p.E52E|COQ6_ENST00000334571.2_Silent_p.E77E|COQ6_ENST00000554920.1_Silent_p.E77E			Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	0				VSWRRWSGA -> AVLAQVVRR (in Ref. 1; AAD27719).	ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	p.E77D(1)		breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		AAGTACTGGAGAAATTGTCAG	0.393000													5	45					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111500773	111500773	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:111500773G>C	ENST00000261486.5	-	23	2251	c.1975C>G	c.(1975-1977)Cag>Gag	p.Q659E	EPB41L4A_ENST00000507810.1_Intron	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	659						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GTAGATGTCTGAGGTTTTTCT	0.363000													7	47					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61935281	61935281	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:61935281C>G	ENST00000577390.1	-	3	1303	c.349G>C	c.(349-351)Gat>Cat	p.D117H	CDH8_ENST00000577730.1_Missense_Mutation_p.D117H|CDH8_ENST00000299345.6_Missense_Mutation_p.D117H|CDH8_ENST00000584337.1_Missense_Mutation_p.D117H	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	117	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCATGGATATCTCCAGTTACA	0.453000													28	73					0	0	1	0	0
NMRK2	27231	broad.mit.edu	37	19	3942109	3942109	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:3942109G>A	ENST00000599576.1	+	5	389	c.325G>A	c.(325-327)Gga>Aga	p.G109R	NMRK2_ENST00000593949.1_Silent_p.E182E|NMRK2_ENST00000168977.2_Silent_p.E177E					nicotinamide riboside kinase 2																		AGTCCCGAGAGGAGCTCTTCC	0.642000													14	71					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17034573	17034573	+	RNA	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:17034573C>T	ENST00000492551.1	-	0	194					NR_026567.1																						CATTCACTCCCCTGCGGAGAC	0.701000													3	8					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33984673	33984673	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:33984673C>G	ENST00000382102.3	-	1	73	c.16G>C	c.(16-18)Ggg>Cgg	p.G6R	SLC45A2_ENST00000509381.1_Missense_Mutation_p.G6R|SLC45A2_ENST00000296589.4_Missense_Mutation_p.G6R|SLC45A2_ENST00000342059.3_Missense_Mutation_p.G6R|SLC45A2_ENST00000345083.5_Missense_Mutation_p.G6R	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	6					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						CCAGCCTGCCCACTGTTGCTA	0.567000													13	49					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233344363	233344363	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:233344363C>T	ENST00000258229.8	-	13	2998	c.2764G>A	c.(2764-2766)Gat>Aat	p.D922N	PCNXL2_ENST00000488780.2_Missense_Mutation_p.D55N|PCNXL2_ENST00000430153.1_Missense_Mutation_p.D221N	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	922						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCCCCTGTATCAAGAAGCAAA	0.433000													3	34					0	0	1	0	0
HTR7	3363	broad.mit.edu	37	10	92508659	92508659	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:92508659G>C	ENST00000371721.3	-	2	1474	c.1232C>G	c.(1231-1233)tCa>tGa	p.S411*	HTR7_ENST00000277874.6_Nonsense_Mutation_p.S411*|HTR7_ENST00000336152.3_Nonsense_Mutation_p.S411*|HTR7_ENST00000371719.2_Nonsense_Mutation_p.S411*			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	411					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	GCCTGCAGCTGAGAGCTTCCG	0.498000													15	115					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170015858	170015858	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:170015858C>G	ENST00000367765.1	-	3	1695	c.194G>C	c.(193-195)gGa>gCa	p.G65A	KIFAP3_ENST00000361580.2_Missense_Mutation_p.G105A|KIFAP3_ENST00000490550.1_5'UTR|KIFAP3_ENST00000367767.1_Missense_Mutation_p.G61A|KIFAP3_ENST00000538366.1_5'UTR	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	105					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTACCTTTTCCTGACAATGA	0.348000													14	112					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86954766	86954766	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:86954766G>C	ENST00000234701.3	+	9	1621	c.1270G>C	c.(1270-1272)Gag>Cag	p.E424Q	CLCA1_ENST00000394711.1_Missense_Mutation_p.E424Q			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	424	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTGCTTTAACGAGGTCAAACA	0.468000													15	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179398781	179398781	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:179398781G>A	ENST00000589042.1	-	358	102785	c.102561C>T	c.(102559-102561)taC>taT	p.Y34187Y	TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN_ENST00000591111.1_Silent_p.Y32546Y|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000460472.2_Silent_p.Y25122Y|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000359218.5_Silent_p.Y25247Y|TTN_ENST00000342992.6_Silent_p.Y31619Y|TTN_ENST00000342175.6_Silent_p.Y25314Y|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000431259.2_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32546	Ser-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCATCTTCGTAGGTGATTT	0.398000													8	51					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90572878	90572878	+	RNA	SNP	A	A	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:90572878A>T	ENST00000551025.1	+	0	2887							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AGAAGAAAATAGGCATATTAG	0.333000													3	17					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160456943	160456943	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:160456943C>G	ENST00000368059.3	-	7	968	c.899G>C	c.(898-900)aGa>aCa	p.R300T	SLAMF6_ENST00000368057.3_Missense_Mutation_p.R301T|SLAMF6_ENST00000368055.1_Missense_Mutation_p.R190T	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	301						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			ATCATTTTCTCTAGGTGTCCA	0.353000													5	37					0	0	1	0	0
ANAPC4	29945	broad.mit.edu	37	4	25418140	25418140	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:25418140C>G	ENST00000315368.3	+	27	2137	c.1995C>G	c.(1993-1995)ctC>ctG	p.L665L	ANAPC4_ENST00000510092.1_Silent_p.L666L	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4	665					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				GAGATAGACTCTTGGTCCAGC	0.368000													13	55					0	0	1	0	0
LRRC31	79782	broad.mit.edu	37	3	169558081	169558081	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:169558081G>T	ENST00000316428.5	-	9	1405	c.1348C>A	c.(1348-1350)Cat>Aat	p.H450N	LRRC31_ENST00000523069.1_3'UTR|LRRC31_ENST00000264676.5_Missense_Mutation_p.H394N	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	450										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTGGCCAGATGACCCGTCTGT	0.473000													6	82					3.59834e-05	3.75016e-05	1	1	0
KRT74	121391	broad.mit.edu	37	12	52963645	52963645	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:52963645G>T	ENST00000549343.1	-	6	1170	c.1132C>A	c.(1132-1134)Cag>Aag	p.Q378K	KRT74_ENST00000305620.2_Missense_Mutation_p.Q378K			Q7RTS7	K2C74_HUMAN	keratin 74	378	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		CTGCCCACCTGCTTCTTCACA	0.582000													21	86					7.41877e-09	8.07241e-09	1	1	0
RCOR1	23186	broad.mit.edu	37	14	103188637	103188637	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:103188637G>A	ENST00000262241.6	+	11	1529	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K	RCOR1_ENST00000570597.1_Missense_Mutation_p.E432K	NM_015156.3	NP_055971.2	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	432					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	12						CAACATAGATGAAGTTTTACA	0.428000													5	140					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30339475	30339475	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:30339475G>C	ENST00000361371.4	-	10	1488	c.1338C>G	c.(1336-1338)ctC>ctG	p.L446L	LTN1_ENST00000389194.2_Silent_p.L492L|LTN1_ENST00000389195.2_Silent_p.L492L	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	446							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						CTGGGTCTTTGAGAACTGCAT	0.388000													15	56					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53561522	53561522	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:53561522C>G	ENST00000342160.3	-	81	13243	c.12786G>C	c.(12784-12786)ctG>ctC	p.L4262L	HUWE1_ENST00000262854.6_Silent_p.L4262L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4262	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TGTTGGATTTCAGATCATCGA	0.478000													10	26					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101442128	101442128	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:101442128C>A	ENST00000392979.3	+	13	1517	c.1156C>A	c.(1156-1158)Ctt>Att	p.L386I	ANO4_ENST00000550015.1_5'UTR|ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.L421I	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	421						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GGTAACCCACCTTTTTGACAA	0.353000										HNSCC(74;0.22)			9	86					1.58986e-06	1.69631e-06	1	1	0
CNOT3	4849	broad.mit.edu	37	19	54656227	54656227	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:54656227G>C	ENST00000406403.1	+	14	3371	c.1768G>C	c.(1768-1770)Gag>Cag	p.E590Q	CNOT3_ENST00000358389.3_Missense_Mutation_p.E409Q|CNOT3_ENST00000496327.1_3'UTR|CNOT3_ENST00000221232.5_Missense_Mutation_p.E590Q			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	590	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCAGCTGTCAGAGGTGAACAT	0.652000													5	106					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52487605	52487605	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:52487605C>G	ENST00000261839.7	-	40	5206	c.5045G>C	c.(5044-5046)aGa>aCa	p.R1682T	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1682	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TGGAGTCACTCTCTTCTCAAA	0.343000													9	40					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	43					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229690	140229690	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140229690C>A	ENST00000378122.3	+	1	2334	c.1610C>A	c.(1609-1611)gCg>gAg	p.A537E	PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.A537E	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGAGCGCGCGCGACGCG	0.667000													47	200					3.10996e-30	3.50758e-30	1	1	0
LRRC73	221424	broad.mit.edu	37	6	43474988	43474988	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:43474988C>T	ENST00000372441.1	-	6	1839	c.939G>A	c.(937-939)gaG>gaA	p.E313E		NM_001012974.1	NP_001012992.1	Q5JTD7	CF154_HUMAN	leucine rich repeat containing 73	313																	ACATCTCGGTCTCAGCCAACA	0.552000											OREG0017453	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	35					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578370	7578370	+	Splice_Site	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:7578370C>A	ENST00000420246.2	-	5	692		c.e5+1		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000574684.1_Splice_Site|TP53_ENST00000359597.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(54)|p.0?(8)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCTGCTCACCATCGCTATC	0.632000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	49					2.87052e-16	3.19378e-16	1	1	0
MED16	10025	broad.mit.edu	37	19	877178	877178	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:877178C>T	ENST00000312090.6	-	9	1506	c.1356G>A	c.(1354-1356)ctG>ctA	p.L452L	MED16_ENST00000395808.3_Silent_p.L452L|MED16_ENST00000589119.1_Silent_p.L452L|MED16_ENST00000606828.1_Intron|MED16_ENST00000325464.1_Silent_p.L452L|MED16_ENST00000269814.4_Silent_p.L452L			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	452					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCACGCTCAGCTGCCAGA	0.687000													4	17					0	0	1	0	0
ZNHIT1	10467	broad.mit.edu	37	7	100867009	100867009	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:100867009C>T	ENST00000305105.2	+	4	857	c.329C>T	c.(328-330)tCg>tTg	p.S110L	ZNHIT1_ENST00000492315.1_3'UTR	NM_006349.2	NP_006340.1	O43257	ZNHI1_HUMAN	zinc finger, HIT-type containing 1	110							metal ion binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)	11	Lung NSC(181;0.168)|all_lung(186;0.215)					GGACCCCCATCGCGGCCCCAG	0.667000													10	79					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1065456	1065456	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:1065456C>G	ENST00000264930.5	-	18	2422	c.2379G>C	c.(2377-2379)atG>atC	p.M793I		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	793					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CGGGCCAGGCCATGAGCACCG	0.657000													5	89					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284408	152284408	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:152284408G>C	ENST00000368799.1	-	3	2989	c.2954C>G	c.(2953-2955)cCc>cGc	p.P985R	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	985	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCTGGGGTGTCTGGA	0.567000									Ichthyosis				60	392					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57550564	57550564	+	Silent	SNP	G	G	A	rs138294603		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:57550564G>A	ENST00000243077.3	+	10	1888	c.1422G>A	c.(1420-1422)agG>agA	p.R474R		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	474	EGF-like 3.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCCAGTGAGGAGCCATGCCT	0.627000													7	20					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538695	63538695	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:63538695C>G	ENST00000550760.3	+	4	1447	c.1268C>G	c.(1267-1269)cCt>cGt	p.P423R		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						GAAGTGAGACCTTACAAATGT	0.398000													11	16					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39832858	39832858	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:39832858G>A	ENST00000309060.3	-	4	1114	c.699C>T	c.(697-699)atC>atT	p.I233I	ZHX3_ENST00000432768.2_Silent_p.I233I|ZHX3_ENST00000560361.1_Silent_p.I233I|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000540170.1_Silent_p.I233I|ZHX3_ENST00000544979.2_Silent_p.I233I|ZHX3_ENST00000559234.1_Silent_p.I233I|ZHX3_ENST00000557816.1_Intron			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	233					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				CTGCCCCATTGATGAAGGAAT	0.562000													21	114					0	0	1	0	0
ECSIT	51295	broad.mit.edu	37	19	11624710	11624710	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:11624710G>A	ENST00000270517.7	-	3	558	c.423C>T	c.(421-423)ttC>ttT	p.F141F	ECSIT_ENST00000417981.2_Intron|ECSIT_ENST00000252440.7_Silent_p.F141F|ECSIT_ENST00000588998.1_Intron|ECSIT_ENST00000592312.1_Silent_p.F25F|ECSIT_ENST00000591104.1_Silent_p.F141F	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	141					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						TGCGAGGCCGGAAGACCTCCT	0.592000													23	40					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152614805	152614805	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:152614805G>A	ENST00000367255.5	-	95	18531	c.17930C>T	c.(17929-17931)aCg>aTg	p.T5977M	SYNE1_ENST00000448038.1_Missense_Mutation_p.T5906M|SYNE1_ENST00000423061.1_Missense_Mutation_p.T5906M|SYNE1_ENST00000356820.4_Missense_Mutation_p.T501M|SYNE1_ENST00000265368.4_Missense_Mutation_p.T5977M|SYNE1_ENST00000341594.5_Missense_Mutation_p.T5589M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5977					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCATCTTCGTAGAGATGGA	0.507000										HNSCC(10;0.0054)			14	49					0	0	1	0	0
KLC1	3831	broad.mit.edu	37	14	104123904	104123904	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:104123904C>A	ENST00000389744.4	+	3	552	c.283C>A	c.(283-285)Cac>Aac	p.H95N	KLC1_ENST00000554280.1_Missense_Mutation_p.H95N|KLC1_ENST00000380038.3_Missense_Mutation_p.H95N|KLC1_ENST00000557575.1_Missense_Mutation_p.H95N|KLC1_ENST00000553286.1_Missense_Mutation_p.H95N|KLC1_ENST00000555836.1_Missense_Mutation_p.H95N|KLC1_ENST00000452929.2_Missense_Mutation_p.H95N|KLC1_ENST00000347839.6_Missense_Mutation_p.H95N|KLC1_ENST00000334553.6_Missense_Mutation_p.H95N|KLC1_ENST00000445352.4_Missense_Mutation_p.H95N|RP11-73M18.2_ENST00000472726.2_Missense_Mutation_p.H267N|KLC1_ENST00000348520.6_Missense_Mutation_p.H95N|KLC1_ENST00000246489.7_Missense_Mutation_p.H95N|KLC1_ENST00000557450.1_Missense_Mutation_p.H95N			Q07866	KLC1_HUMAN	kinesin light chain 1	95					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				TTTGTCAAATCACCTGAATGC	0.552000													6	51					8.12818e-05	8.41787e-05	1	1	0
LRRC8E	80131	broad.mit.edu	37	19	7964750	7964750	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:7964750G>A	ENST00000539278.1	-	1	3677	c.517C>T	c.(517-519)Cag>Tag	p.Q173*	LRRC8E_ENST00000306708.6_Missense_Mutation_p.C448Y																							GAGGCCATCTGCGATATCACC	0.657000													4	34					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008255	11008255	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:11008255G>C	ENST00000377004.4	-	12	1936	c.1937C>G	c.(1936-1938)tCa>tGa	p.S646*	C1orf127_ENST00000377008.4_Nonsense_Mutation_p.S479*	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	497										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GCTTGGTTCTGAGGATGAAAG	0.652000													15	75					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940192	144940192	+	Silent	SNP	C	C	T	rs6982684		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:144940192C>T	ENST00000525985.1	-	2	7301	c.7230G>A	c.(7228-7230)acG>acA	p.T2410T				P58107	EPIPL_HUMAN	epiplakin 1	2410						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATAGGAGCCCCGTCTCAGGGT	0.577000													6	44					0	0	1	0	0
ANXA13	312	broad.mit.edu	37	8	124693544	124693544	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:124693544G>C	ENST00000262219.6	-	12	1077	c.1010C>G	c.(1009-1011)tCt>tGt	p.S337C	ANXA13_ENST00000419625.1_Missense_Mutation_p.S296C	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	296					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			AACCATGTCAGAGAGAGACTT	0.488000													29	270					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1818085	1818085	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:1818085G>A	ENST00000250894.4	+	29	3693	c.3536G>A	c.(3535-3537)cGa>cAa	p.R1179Q	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.R1173Q	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	1179					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						GTCCTGCACCGAGGCCAGCTC	0.677000													14	81					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790076	133790076	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:133790076G>A	ENST00000321016.8	-	18	3774	c.3544C>T	c.(3544-3546)Cgg>Tgg	p.R1182W	IGSF9B_ENST00000533871.2_Missense_Mutation_p.R1182W			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1182	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGGCCTGCCGAGGGCTAGGC	0.716000													4	49					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117392001	117392001	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:117392001C>A	ENST00000321322.6	-	6	1238	c.1237G>T	c.(1237-1239)Gag>Tag	p.E413*	DSCAML1_ENST00000527706.1_Nonsense_Mutation_p.E143*	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	353	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGCACCAGCTCCGTGTTGCGA	0.627000													21	59					9.95505e-16	1.10512e-15	1	1	0
SMOX	54498	broad.mit.edu	37	20	4164241	4164241	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:4164241C>T	ENST00000305958.4	+	6	1695	c.1470C>T	c.(1468-1470)agC>agT	p.S490S	SMOX_ENST00000379460.2_Silent_p.S490S|SMOX_ENST00000339123.6_Silent_p.S437S|SMOX_ENST00000278795.3_Silent_p.S437S|SMOX_ENST00000346595.2_Intron	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	490					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	TGGGCTCCAGCGGGGCGGATG	0.622000													11	63					0	0	1	0	0
DNAJC2	27000	broad.mit.edu	37	7	102953441	102953441	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:102953441C>T	ENST00000379263.3	-	16	1994	c.1744G>A	c.(1744-1746)Gaa>Aaa	p.E582K	DNAJC2_ENST00000249270.7_Missense_Mutation_p.E529K|PMPCB_ENST00000420236.2_Intron|PMPCB_ENST00000249269.4_3'UTR	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	582	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						GGCACCGCTTCTGCTATTTTT	0.408000													28	136					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963269	73963269	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:73963269C>G	ENST00000373468.1	-	3	1774	c.1123G>C	c.(1123-1125)Gag>Cag	p.E375Q	KIAA2022_ENST00000055682.5_Missense_Mutation_p.E375Q			Q5QGS0	K2022_HUMAN	KIAA2022	375					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTATCTTCCTCCCCCCAGATG	0.473000													19	57					0	0	1	0	0
ZNF85	7639	broad.mit.edu	37	19	21116874	21116874	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:21116874G>T	ENST00000328178.8	+	2	161	c.48G>T	c.(46-48)aaG>aaT	p.K16N	ZNF85_ENST00000345030.6_Missense_Mutation_p.K16N|ZNF85_ENST00000300540.3_Missense_Mutation_p.K16N|ZNF85_ENST00000596476.1_5'UTR|ZNF85_ENST00000597314.1_Missense_Mutation_p.K16N	NM_001256173.1|NM_003429.4	NP_001243102.1|NP_003420.2	Q03923	ZNF85_HUMAN	zinc finger protein 85	16	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						TCTCTCTGAAGGAGTGGCAAT	0.433000													28	165					1.77063e-15	1.96119e-15	1	1	0
STK19	8859	broad.mit.edu	37	6	31939957	31939957	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:31939957G>C	ENST00000375331.2	+	1	350	c.184G>C	c.(184-186)Ggc>Cgc	p.G62R	DOM3Z_ENST00000337523.5_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|STK19_ENST00000375333.2_Missense_Mutation_p.G62R|DOM3Z_ENST00000375349.3_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	62						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GCCAATCCGCGGCCGGCGTGG	0.711000													6	42					0	0	1	0	0
PMEL	6490	broad.mit.edu	37	12	56350808	56350808	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:56350808T>A	ENST00000548747.1	-	6	1941	c.1279A>T	c.(1279-1281)Aca>Tca	p.T427S	PMEL_ENST00000360714.4_Missense_Mutation_p.T427S|PMEL_ENST00000548493.1_Missense_Mutation_p.T427S|PMEL_ENST00000552882.1_Missense_Mutation_p.T427S|PMEL_ENST00000536427.1_Missense_Mutation_p.T385S|PMEL_ENST00000550447.1_Intron|PMEL_ENST00000449260.2_Missense_Mutation_p.T427S|PMEL_ENST00000550464.1_Missense_Mutation_p.T341S|PMEL_ENST00000539511.1_Missense_Mutation_p.T341S			P40967	PMEL_HUMAN	premelanosome protein	427	10 X 13 AA approximate tandem repeats, RPT domain.				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TCTCTAGCTGTGGtctccacc	0.493000													5	40					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54607069	54607069	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:54607069G>A	ENST00000371330.1	-	3	1312	c.465C>T	c.(463-465)gtC>gtT	p.V155V	RP11-446E24.4_ENST00000525949.1_5'UTR	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	155	CUB 2.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						GACTGGTGAGGACCCCTGACA	0.607000													8	29					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008290	65008290	+	Silent	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:65008290G>T	ENST00000247207.6	+	1	1105	c.723G>T	c.(721-723)gtG>gtT	p.V241V	HSPA2_ENST00000554883.1_3'UTR|HSPA2_ENST00000394709.1_Silent_p.V241V	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	241					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		ACCGCATGGTGAGCCACCTGG	0.647000													5	77					2.0095e-06	2.13942e-06	1	1	0
ACAN	176	broad.mit.edu	37	15	89400509	89400509	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:89400509G>A	ENST00000439576.2	+	12	5067	c.4693G>A	c.(4693-4695)Gac>Aac	p.D1565N	ACAN_ENST00000559004.1_Missense_Mutation_p.D1565N|ACAN_ENST00000561243.1_Missense_Mutation_p.D1565N|ACAN_ENST00000352105.7_Missense_Mutation_p.D1565N	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1565					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTAGGGACTGACCTCAGTGG	0.522000													11	51					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37889995	37889995	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:37889995C>G	ENST00000199447.4	+	4	421	c.49C>G	c.(49-51)Caa>Gaa	p.Q17E	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.Q17E	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	17	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										CATCAATAATCAAAGCCTGTG	0.488000													25	139					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42058385	42058385	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:42058385C>T	ENST00000219905.7	+	24	8286	c.8105C>T	c.(8104-8106)tCt>tTt	p.S2702F	MGA_ENST00000570161.1_Missense_Mutation_p.S2702F|MGA_ENST00000545763.1_Missense_Mutation_p.S2493F|MGA_ENST00000566586.1_Missense_Mutation_p.S2493F|MGA_ENST00000389936.4_Missense_Mutation_p.S2663F	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2663						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGTAGAATCTCTTCCAGAGGA	0.428000													5	22					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358936	102358936	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:102358936C>T	ENST00000332238.4	+	1	571	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGATCTCCCTCGGCTCCTCAG	0.428000													19	132					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84270599	84270599	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:84270599C>T	ENST00000428679.2	-	27	3103	c.2510G>A	c.(2509-2511)gGa>gAa	p.G837E	SNAP91_ENST00000520302.1_Missense_Mutation_p.G807E|SNAP91_ENST00000369694.2_Missense_Mutation_p.G837E|SNAP91_ENST00000520213.1_Missense_Mutation_p.G530E|SNAP91_ENST00000521743.1_Missense_Mutation_p.G837E|SNAP91_ENST00000437520.1_Missense_Mutation_p.G530E|SNAP91_ENST00000439399.2_Missense_Mutation_p.G837E|SNAP91_ENST00000521485.1_Missense_Mutation_p.G832E|SNAP91_ENST00000195649.6_Missense_Mutation_p.G832E			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	837	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding	p.G837A(4)		breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		AAATCCTGCTCCAGGTTGTCC	0.418000													3	23					0	0	1	0	0
NSUN3	63899	broad.mit.edu	37	3	93803224	93803224	+	Silent	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:93803224G>T	ENST00000314622.4	+	3	607	c.396G>T	c.(394-396)ggG>ggT	p.G132G		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	132							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						TAAGGGATGGGGAGAAGGTTC	0.448000													7	66					1.06961e-07	1.15369e-07	1	1	0
TYW1B	441250	broad.mit.edu	37	7	72178588	72178588	+	RNA	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:72178588G>A	ENST00000438125.1	-	0	974							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										CCTGATTTCCGCAGGAAATTG	0.413000													6	51					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240528	126240528	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:126240528G>T	ENST00000394329.3	+	1	2975	c.2962G>T	c.(2962-2964)Gat>Tat	p.D988Y		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	988	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTATGTCCATGATGTAAATGA	0.428000													14	96					3.27435e-08	3.53945e-08	1	1	0
TET1	80312	broad.mit.edu	37	10	70405188	70405188	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:70405188C>T	ENST00000373644.4	+	4	2911	c.2702C>T	c.(2701-2703)tCa>tTa	p.S901L		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	901					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ACTCAACTCTCAGAAGCCCCA	0.453000													35	234					0	0	1	0	0
MBD4	8930	broad.mit.edu	37	3	129151307	129151307	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:129151307G>C	ENST00000507208.1	-	7	1905	c.1704C>G	c.(1702-1704)gtC>gtG	p.V568V	MBD4_ENST00000393278.2_Intron|MBD4_ENST00000249910.1_Intron|MBD4_ENST00000503197.1_Intron|MBD4_ENST00000429544.2_Intron	NM_001276271.1	NP_001263200.1	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	0			D -> H (in dbSNP:rs2307293).		depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)	22						TTGCCTCAGAGACCAAATGTG	0.423000								Base excision repair (BER), DNA glycosylases					12	69					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29455369	29455369	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:29455369G>A	ENST00000377127.3	-	1	369	c.311C>T	c.(310-312)gCc>gTc	p.A104V		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	104						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GGGATTCGTGGCCCCACAGCA	0.547000													14	33					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57756644	57756644	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:57756644C>G	ENST00000371236.2	-	2	322	c.59G>C	c.(58-60)aGa>aCa	p.R20T	DAB1_ENST00000439789.2_Missense_Mutation_p.R20T|DAB1_ENST00000371234.4_Missense_Mutation_p.R20T|DAB1_ENST00000420954.2_Missense_Mutation_p.R20T|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371230.1_Missense_Mutation_p.R20T|DAB1_ENST00000414851.2_Missense_Mutation_p.R20T|DAB1_ENST00000371231.1_Missense_Mutation_p.R20T			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	20					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						ACCTTTCTTTCTGGAGTCTTT	0.398000													8	47					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183201866	183201866	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:183201866C>G	ENST00000264144.4	+	14	2159	c.2094C>G	c.(2092-2094)ctC>ctG	p.L698L	LAMC2_ENST00000493293.1_Silent_p.L698L	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	698	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TGGATGACCTCAAGATGACTG	0.552000													5	113					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6141576	6141576	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:6141576C>G	ENST00000586696.1	+	2	298	c.22C>G	c.(22-24)Caa>Gaa	p.Q8E	ACSBG2_ENST00000591403.1_Missense_Mutation_p.Q8E|ACSBG2_ENST00000588304.1_5'UTR|ACSBG2_ENST00000588485.1_5'UTR|ACSBG2_ENST00000252669.5_Missense_Mutation_p.Q8E			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	8					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCCAAAGACTCAAGAAGGAGC	0.448000													7	46					0	0	1	0	0
DNAJC8	22826	broad.mit.edu	37	1	28559461	28559461	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:28559461C>T	ENST00000263697.4	-	1	75	c.49G>A	c.(49-51)Gag>Aag	p.E17K	DNAJC8_ENST00000489277.1_5'UTR	NM_014280.2	NP_055095.2	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	17					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		AATGCTTCCTCGGTGCTGCCT	0.632000													6	65					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173997312	173997312	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:173997312C>T	ENST00000457714.1	+	6	1950	c.1521C>T	c.(1519-1521)gaC>gaT	p.D507D	NLGN1_ENST00000401917.3_Silent_p.D547D|NLGN1_ENST00000361589.4_Silent_p.D507D|NLGN1_ENST00000545397.1_Silent_p.D507D	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	524					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity	p.D507D(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCCACGGAGACGAGGTTCCCT	0.453000													4	61					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128930293	128930293	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:128930293C>T	ENST00000375990.3	+	29	3582	c.3179C>T	c.(3178-3180)tCt>tTt	p.S1060F	UGGT1_ENST00000259253.6_Missense_Mutation_p.S1084F			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1084					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ATGGTAGAATCTGTCAGAACA	0.358000													10	79					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66205295	66205295	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:66205295G>T	ENST00000503581.1	-	4	546	c.9C>A	c.(7-9)gaC>gaA	p.D3E	EYS_ENST00000393380.2_Missense_Mutation_p.D3E|EYS_ENST00000342421.5_Missense_Mutation_p.D3E|EYS_ENST00000370616.2_Missense_Mutation_p.D3E|EYS_ENST00000370618.3_Missense_Mutation_p.D3E|EYS_ENST00000370621.3_Missense_Mutation_p.D3E	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	3					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CGATTGATTTGTCAGTCATTT	0.373000													48	33					1.00776e-21	1.12887e-21	1	1	0
MLH3	27030	broad.mit.edu	37	14	75514858	75514858	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:75514858A>G	ENST00000355774.2	-	2	1716	c.1501T>C	c.(1501-1503)Tgt>Cgt	p.C501R	MLH3_ENST00000556740.1_Missense_Mutation_p.C501R|MLH3_ENST00000238662.7_Missense_Mutation_p.C501R|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000556257.1_Missense_Mutation_p.C501R	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	501					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		CTGGTTCCACACGGATTTTCT	0.368000								Mismatch excision repair (MMR)					11	88					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542690	61542690	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:61542690G>C	ENST00000266070.4	-	3	600	c.275C>G	c.(274-276)tCc>tGc	p.S92C	DIDO1_ENST00000370371.4_Missense_Mutation_p.S92C|DIDO1_ENST00000370368.1_Missense_Mutation_p.S92C|DIDO1_ENST00000266071.5_Missense_Mutation_p.S92C|DIDO1_ENST00000354665.4_Missense_Mutation_p.S92C|DIDO1_ENST00000395343.1_Missense_Mutation_p.S92C|DIDO1_ENST00000395335.2_Missense_Mutation_p.S92C|DIDO1_ENST00000370366.1_Missense_Mutation_p.S92C|DIDO1_ENST00000395340.1_Missense_Mutation_p.S92C	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	92					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ATCCTCCAGGGAGACAGGCAT	0.692000													9	38					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17076067	17076067	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:17076067G>C	ENST00000395811.5	+	17	2456	c.2367G>C	c.(2365-2367)aaG>aaC	p.K789N	MPRIP_ENST00000395804.3_Missense_Mutation_p.K789N|MPRIP_ENST00000341712.4_Missense_Mutation_p.K789N|RP11-45M22.3_ENST00000584203.1_RNA|MPRIP_ENST00000444976.1_Missense_Mutation_p.K751N	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	789	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						AGCTGGAGAAGAGCCAGCGGT	0.652000													20	80					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49443973	49443973	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:49443973G>C	ENST00000301067.7	-	11	3397	c.3398C>G	c.(3397-3399)tCa>tGa	p.S1133*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CTCTGGCTGTGAACCCGGAGC	0.637000													9	23					0	0	1	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216705	26216705	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:26216705G>A	ENST00000244601.3	-	1	167	c.167C>T	c.(166-168)tCa>tTa	p.S56L		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	56					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				GGCCTTGGATGAGATGCCAGT	0.537000													30	194					0	0	1	0	0
CAMKMT	79823	broad.mit.edu	37	2	44931436	44931436	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:44931436G>C	ENST00000378494.3	+	4	435	c.391G>C	c.(391-393)Gaa>Caa	p.E131Q		NM_024766.3	NP_079042.1	Q7Z624	CMKMT_HUMAN	calmodulin-lysine N-methyltransferase	131						cytoplasm	calmodulin-lysine N-methyltransferase activity			breast(2)|large_intestine(3)|lung(5)	10						CTGGCCATCTGAAGAGGTTTT	0.353000													8	73					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50163416	50163416	+	RNA	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:50163416C>A	ENST00000376025.2	-	0	986							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AAATTTCTCCCTGTTGGATGG	0.353000													11	35					5.50884e-06	5.82734e-06	1	1	0
GOLGA2	2801	broad.mit.edu	37	9	131027891	131027891	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:131027891G>C	ENST00000421699.2	-	11	837	c.825C>G	c.(823-825)gtC>gtG	p.V275V		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	275						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GCTGCGTGGAGACAGCAGAGA	0.602000													8	36					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092206	30092206	+	RNA	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr18:30092206C>A	ENST00000567636.1	+	0	581					NR_003558.1																						GAATGCCCAGCACGTGGAAGT	0.423000													4	4					0.150653	0.151266	1	1	0
CYP4F12	66002	broad.mit.edu	37	19	15794516	15794516	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:15794516C>G	ENST00000550308.1	+	7	1241	c.861C>G	c.(859-861)ttC>ttG	p.F287L	CYP4F12_ENST00000324632.9_Missense_Mutation_p.F287L	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATGATTTTTTCAAAGACAAAG	0.507000													19	99					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75936882	75936882	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:75936882G>C	ENST00000274364.6	+	17	2345	c.2048G>C	c.(2047-2049)aGa>aCa	p.R683T	IQGAP2_ENST00000396234.3_Intron|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000502745.1_Intron	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	683					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TTTGAAGCTAGAAAATCATTT	0.408000													6	34					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54668242	54668242	+	Missense_Mutation	SNP	G	G	C	rs140280199		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:54668242G>C	ENST00000376591.4	-	7	1188	c.1057C>G	c.(1057-1059)Ctg>Gtg	p.L353V	TMC4_ENST00000301187.4_Missense_Mutation_p.L347V	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	353						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACCACCAGCAGGTTGAGCAGC	0.672000													28	144					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109155467	109155467	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:109155467A>G	ENST00000261483.4	+	14	3259	c.2207A>G	c.(2206-2208)tAt>tGt	p.Y736C		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	736					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TATGTCTTGTATAAGAATAAA	0.328000													27	127					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013431	73013431	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:73013431C>A	ENST00000308744.6	+	4	1569	c.1471C>A	c.(1471-1473)Cat>Aat	p.H491N	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Missense_Mutation_p.H389N|NPFFR2_ENST00000395999.1_Missense_Mutation_p.H392N	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	491					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity	p.H491D(1)		NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCAAAACCCTCATGGGGAAAC	0.378000													98	64					3.53432e-41	3.99532e-41	1	1	0
RAVER1	125950	broad.mit.edu	37	19	10444069	10444069	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:10444069G>A	ENST00000293677.6	-	1	247	c.166C>T	c.(166-168)Cta>Tta	p.L56L		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	39						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TCTGGATCTAGAGGCGGCAGC	0.667000													6	73					0	0	1	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15116352	15116352	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:15116352C>T	ENST00000253699.3	-	14	1905	c.1292G>A	c.(1291-1293)cGc>cAc	p.R431H	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R431H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	431	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB4A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						AGGGCCCCTGCGGAGAGATGC	0.657000													13	37					0	0	1	0	0
ZNF420	147923	broad.mit.edu	37	19	37618875	37618875	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:37618875A>G	ENST00000337995.3	+	5	1197	c.982A>G	c.(982-984)Att>Gtt	p.I328V	ZNF420_ENST00000304239.7_Missense_Mutation_p.I328V|ZNF585A_ENST00000588723.1_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATCAGAAAATTCATAATGG	0.388000													41	70					0	0	1	0	0
SYPL1	6856	broad.mit.edu	37	7	105733542	105733542	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:105733542C>T	ENST00000455385.2	-	4	566	c.444G>A	c.(442-444)gtG>gtA	p.V148V	SYPL1_ENST00000470347.1_Silent_p.V148V|SYPL1_ENST00000011473.2_Silent_p.V166V	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	166	MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						CTGAAGTGCTCACCAACCACA	0.343000													9	23					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432443	140432443	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140432443A>C	ENST00000306549.3	+	1	1465	c.1388A>C	c.(1387-1389)gAa>gCa	p.E463A		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		463	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGTTCGAGAAAACAACAGT	0.418000													25	83					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4042260	4042260	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:4042260C>G	ENST00000294016.3	-	5	2632	c.2094G>C	c.(2092-2094)gaG>gaC	p.E698D	ADCY9_ENST00000571889.1_5'UTR	NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	698					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						ACCTTCCCTTCTCCTGCAAGA	0.567000													9	76					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193232601	193232601	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:193232601G>C	ENST00000342695.4	-	2	442	c.120C>G	c.(118-120)atC>atG	p.I40M	ATP13A4_ENST00000295548.3_Missense_Mutation_p.I40M|ATP13A4_ENST00000392443.3_Missense_Mutation_p.I40M	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	40					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CAAATGAGAAGATGGATCCGG	0.478000													15	97					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102305092	102305092	+	RNA	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:102305092A>G	ENST00000561463.1	+	0	13138																											CATGAACACCATCAGCACAGC	0.632000													3	25					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82785939	82785939	+	Translation_Start_Site	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:82785939G>A	ENST00000512590.2	+	0	359				VCAN_ENST00000502527.2_Silent_p.P31P|VCAN_ENST00000265077.3_Silent_p.P31P|VCAN_ENST00000342785.4_Silent_p.P31P|VCAN_ENST00000343200.5_Silent_p.P31P|VCAN_ENST00000513984.1_Silent_p.P31P			P13611	CSPG2_HUMAN	versican						cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAGCCCACCGGTGAGGGGCT	0.408000													12	56					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799213	5799213	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:5799213A>T	ENST00000317093.2	-	1	684	c.652T>A	c.(652-654)Ttt>Att	p.F218I	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		CAAATGTCAAACACTCCAATC	0.453000													15	49					0	0	1	0	0
HMG20B	10362	broad.mit.edu	37	19	3576599	3576599	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:3576599G>A	ENST00000333651.6	+	7	643	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K		NM_006339.2	NP_006330.2	Q9P0W2	HM20B_HUMAN	high mobility group 20B	190					blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCTTCACTGAAGAGTTCTT	0.582000													5	46					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157097	22157097	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:22157097G>C	ENST00000397126.4	-	4	887	c.739C>G	c.(739-741)Cat>Gat	p.H247D	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTACCTTATGTTTAGTAAGG	0.353000													10	49					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187177228	187177228	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:187177228C>A	ENST00000264690.6	+	13	1759	c.1572C>A	c.(1570-1572)ttC>ttA	p.F524L	KLKB1_ENST00000513864.1_Missense_Mutation_p.F524L	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	524	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GATGGGGCTTCTCGAAGGAGA	0.388000													13	29					0.0202918	0.0204993	1	1	0
IFT172	26160	broad.mit.edu	37	2	27676309	27676309	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:27676309C>A	ENST00000260570.3	-	35	3996	c.3893G>T	c.(3892-3894)tGc>tTc	p.C1298F		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1298					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TTTGAGGTAGCAGTCCACGGC	0.607000													17	77					1.67942e-08	1.82337e-08	1	1	0
CADM4	199731	broad.mit.edu	37	19	44127506	44127506	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:44127506C>G	ENST00000222374.2	-	9	1191	c.1143G>C	c.(1141-1143)aaG>aaC	p.K381N		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	381					cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				CCTCTTTCCTCTTGTGTCCGT	0.592000													35	130					0	0	1	0	0
CPQ	10404	broad.mit.edu	37	8	98078254	98078254	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:98078254C>A	ENST00000220763.5	+	7	1281	c.1071C>A	c.(1069-1071)taC>taA	p.Y357*	CPQ_ENST00000529551.1_3'UTR	NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	357					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										TTTCCAACTACAGTCTGGTGA	0.443000													8	63					7.48243e-07	8.01805e-07	1	1	0
PREX2	80243	broad.mit.edu	37	8	69104621	69104621	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:69104621T>C	ENST00000288368.4	+	37	4742	c.4465T>C	c.(4465-4467)Ttt>Ctt	p.F1489L		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1489					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GGTAGCCTCGTTTATCAGATC	0.483000													10	54					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124982286	124982286	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:124982286C>T	ENST00000522917.1	+	6	602	c.396C>T	c.(394-396)ttC>ttT	p.F132F	FER1L6_ENST00000399018.1_Silent_p.F132F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	132	C2 1.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACTTTGTCTTCGACTTCATTG	0.413000													13	113					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5649944	5649944	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:5649944G>A	ENST00000292123.5	+	8	1263	c.1156G>A	c.(1156-1158)Gaa>Aaa	p.E386K	SAFB_ENST00000588852.1_Missense_Mutation_p.E386K|SAFB_ENST00000538656.1_Missense_Mutation_p.E229K|SAFB_ENST00000433404.1_Missense_Mutation_p.E216K|SAFB_ENST00000454510.1_Missense_Mutation_p.E317K|SAFB_ENST00000592224.1_Missense_Mutation_p.E386K|SAFB_ENST00000586934.1_3'UTR	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	386					chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TAGTTCTCCCGAAGATGACTC	0.498000													7	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479306	25479306	+	RNA	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:25479306C>A	ENST00000453082.2	+	0	1847					NR_003343.1																						CTGACCCTTCCTGACTCCGTG	0.607000													13	70					5.50884e-06	5.82734e-06	1	1	0
MYO1H	283446	broad.mit.edu	37	12	109838970	109838970	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:109838970G>C	ENST00000310903.5	+	6	701	c.595G>C	c.(595-597)Gag>Cag	p.E199Q	MYO1H_ENST00000431443.2_Missense_Mutation_p.E199Q			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AAACGAAGGCGAGCGGAATTT	0.507000													7	33					0	0	1	0	0
CLIP3	25999	broad.mit.edu	37	19	36508835	36508835	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:36508835G>C	ENST00000360535.4	-	10	1469	c.1242C>G	c.(1240-1242)gcC>gcG	p.A414A	AC002116.7_ENST00000586962.1_RNA|CLIP3_ENST00000593074.1_Silent_p.A414A	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	414					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCTCAGCCTTGGCCCCGTCAC	0.612000													8	71					0	0	1	0	0
B2M	567	broad.mit.edu	37	15	45007842	45007842	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:45007842G>A	ENST00000558401.1	+	2	359	c.289G>A	c.(289-291)Gag>Aag	p.E97K	B2M_ENST00000559220.1_Intron|B2M_ENST00000559916.1_Missense_Mutation_p.E97K|B2M_ENST00000544417.1_Missense_Mutation_p.E97K	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	97	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.E97K(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TGAAAAAGATGAGTATGCCTG	0.418000													26	80					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93593126	93593126	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:93593126G>A	ENST00000394236.3	-	15	2310	c.1994C>T	c.(1993-1995)tCa>tTa	p.S665L	PROS1_ENST00000407433.1_Missense_Mutation_p.S534L	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	665	Laminin G-like 2.		S -> L (in PROS1D).		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TGATGGACATGAGTGAGCTCT	0.333000													7	44					0	0	1	0	0
OBSL1	23363	broad.mit.edu	37	2	220416900	220416900	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:220416900C>T	ENST00000404537.1	-	19	5403	c.5347G>A	c.(5347-5349)Gag>Aag	p.E1783K	OBSL1_ENST00000373876.1_Missense_Mutation_p.E1691K|OBSL1_ENST00000265318.4_3'UTR	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	1783					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCGGCGTCCTCGGCGCGCAGC	0.662000													3	14					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891323	44891323	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:44891323G>A	ENST00000330997.4	-	4	1148	c.1084C>T	c.(1084-1086)Cat>Tat	p.H362Y	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Missense_Mutation_p.H362Y|ZNF285_ENST00000591679.1_Missense_Mutation_p.H369Y	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						ACTCCCTGATGAATACAAAGA	0.473000													12	52					0	0	1	0	0
MGAT4A	11320	broad.mit.edu	37	2	99256635	99256635	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:99256635G>A	ENST00000393487.1	-	11	1390	c.1077C>T	c.(1075-1077)ttC>ttT	p.F359F	MGAT4A_ENST00000409391.1_Silent_p.F359F|MGAT4A_ENST00000414521.2_Silent_p.F231F|MGAT4A_ENST00000264968.2_Silent_p.F359F	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	359					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						CAACATGTTGGAAAAGGGAAG	0.333000													5	41					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19937259	19937259	+	Splice_Site	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:19937259C>G	ENST00000255006.6	+	4	455	c.305_splice	c.e4-1	p.S102_splice	RIN2_ENST00000440354.2_Splice_Site_p.S53_splice|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	53	SH2.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						TTTCTCCTAGCATGGTAAGAC	0.557000													5	19					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52188791	52188791	+	Silent	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:52188791A>G	ENST00000395718.2	+	12	1746	c.1461A>G	c.(1459-1461)ggA>ggG	p.G487G	FRMD6_ENST00000553556.1_Silent_p.G137G|FRMD6_ENST00000356218.4_Silent_p.G487G|FRMD6_ENST00000344768.5_Silent_p.G495G|FRMD6_ENST00000554167.1_Silent_p.G418G	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	495						cytoskeleton|mitochondrion|plasma membrane	binding	p.G487G(1)		breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					AGCTGAATGGACACTCTGGTG	0.507000													3	54					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355802	201355802	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:201355802C>T	ENST00000391967.2	-	3	988	c.687G>A	c.(685-687)aaG>aaA	p.K229K	LAD1_ENST00000367313.3_Silent_p.K243K	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	229	8 X SEK repeats.					basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						GAACAGACTTCTTCTCTGAGC	0.493000													29	229					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137154323	137154323	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:137154323G>A	ENST00000453654.1	-	25	2109	c.1570C>T	c.(1570-1572)Ctc>Ttc	p.L524F	DGKI_ENST00000424189.2_Missense_Mutation_p.L827F|DGKI_ENST00000288490.5_Missense_Mutation_p.L824F|DGKI_ENST00000446122.1_Missense_Mutation_p.L806F			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	824					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CGAGGAGAGAGCCTCTGTGCT	0.527000													7	34					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93825	93825	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:93825G>C	ENST00000447903.2	-	4	606	c.291C>G	c.(289-291)atC>atG	p.I97M	TUBB8_ENST00000309812.4_Missense_Mutation_p.I169M|TUBB8_ENST00000332708.5_3'UTR|TUBB8_ENST00000413237.3_5'UTR			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	169					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCGAGGGCAGGATGCTGAATG	0.577000													7	237					0	0	1	0	0
USP1	7398	broad.mit.edu	37	1	62915974	62915974	+	Silent	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:62915974T>A	ENST00000339950.4	+	9	2495	c.1680T>A	c.(1678-1680)ctT>ctA	p.L560L	USP1_ENST00000371146.1_Silent_p.L560L	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	560					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		TGACACCTCTTAAATTGTCAC	0.388000													34	84					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47290154	47290154	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:47290154G>C	ENST00000467728.1	+	9	2489	c.1251G>C	c.(1249-1251)ctG>ctC	p.L417L	NR1H3_ENST00000405853.3_Silent_p.L357L|NR1H3_ENST00000527949.1_Silent_p.L266L|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000405576.1_Silent_p.L312L|NR1H3_ENST00000441012.2_Silent_p.L417L|NR1H3_ENST00000407404.1_Silent_p.L357L|NR1H3_ENST00000395397.3_Silent_p.L372L|NR1H3_ENST00000481889.2_Silent_p.L436L			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	417	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						TCCGGACCCTGAGCAGCGTCC	0.552000													10	94					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86832164	86832164	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:86832164G>C	ENST00000237455.4	-	4	1828	c.860C>G	c.(859-861)tCa>tGa	p.S287*	AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000424788.1_RNA|RNF103-CHMP3_ENST00000604011.1_Intron|CHMP3_ENST00000439940.2_Intron|AC015971.2_ENST00000597638.1_RNA|RNF103_ENST00000477307.1_5'UTR	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	287					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						AAGTATGTATGATGGCATATT	0.338000													5	60					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23399802	23399802	+	Nonsense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:23399802C>G	ENST00000400181.4	+	15	1744	c.1640C>G	c.(1639-1641)tCa>tGa	p.S547*	RP1-184J9.2_ENST00000427154.1_RNA|KDM1A_ENST00000356634.3_Nonsense_Mutation_p.S523*|KDM1A_ENST00000542151.1_Nonsense_Mutation_p.S547*	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	523	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TATCTCTCATCAAGAGACAGA	0.388000													14	106					0	0	1	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66776474	66776474	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:66776474G>A	ENST00000258198.2	-	4	602	c.396C>T	c.(394-396)ctC>ctT	p.L132L	DYNC1LI2_ENST00000443351.2_Intron|DYNC1LI2_ENST00000440564.2_Silent_p.L93L|DYNC1LI2_ENST00000379482.2_Silent_p.L132L	NM_006141.2	NP_006132.1	O43237	DC1L2_HUMAN	dynein, cytoplasmic 1, light intermediate chain 2	132					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(4)|stomach(1)	15		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		CAAAAATGACGAGGGTCTCTG	0.453000													18	86					0	0	1	0	0
HOXB8	3218	broad.mit.edu	37	17	46690726	46690726	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:46690726G>C	ENST00000239144.4	-	2	804	c.570C>G	c.(568-570)gtC>gtG	p.V190V	HOXB8_ENST00000576562.1_Silent_p.V189V|HOXB7_ENST00000567101.1_Intron	NM_024016.3	NP_076921.1	P17481	HXB8_HUMAN	homeobox B8	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(8)|urinary_tract(2)	11						ACCAGATTTTGACCTGTCTCT	0.507000													14	100					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238253245	238253245	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:238253245C>T	ENST00000295550.4	-	36	7868	c.7416G>A	c.(7414-7416)aaG>aaA	p.K2472K	COL6A3_ENST00000353578.4_Silent_p.K2266K|COL6A3_ENST00000409809.1_Silent_p.K2266K|COL6A3_ENST00000472056.1_Silent_p.K1865K|COL6A3_ENST00000347401.3_Silent_p.K2271K|COL6A3_ENST00000346358.4_Silent_p.K2272K	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2472	Nonhelical region.|VWFA 11.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTTCTTAATCTTGTCCAGGA	0.562000													8	73					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256172	140256172	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140256172T>G	ENST00000398631.2	+	1	1115	c.1115T>G	c.(1114-1116)aTt>aGt	p.I372S	PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGCCCTGATTAGCGTGTCG	0.507000													18	104					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133925338	133925338	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:133925338G>A	ENST00000220616.4	+	20	4246	c.4206G>A	c.(4204-4206)ctG>ctA	p.L1402L	TG_ENST00000377869.1_Silent_p.L1402L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1402					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCACAGATCTGATCCAGAGTG	0.562000													12	57					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25464361	25464361	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:25464361G>A	ENST00000376351.3	+	1	371	c.12G>A	c.(10-12)atG>atA	p.M4I	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	4						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TGGGAGCCATGGCTTACCCCT	0.572000													11	65					0	0	1	0	0
LHFPL1	340596	broad.mit.edu	37	X	111914334	111914334	+	Silent	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:111914334C>A	ENST00000371968.3	-	2	524	c.285G>T	c.(283-285)ctG>ctT	p.L95L	LHFPL1_ENST00000478229.1_Intron|LHFPL1_ENST00000536453.1_Silent_p.L95L	NM_178175.3	NP_835469.1	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1	95						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)	13						CCACCAGGAGCAGCAGAGCAC	0.582000													9	45					3.09899e-07	3.33529e-07	1	1	0
OR2T27	403239	broad.mit.edu	37	1	248814164	248814164	+	Missense_Mutation	SNP	C	C	T	rs144642254		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:248814164C>T	ENST00000344889.3	-	1	21	c.22G>A	c.(22-24)Gtg>Atg	p.V8M		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCGGCATACACGGAATAATTG	0.433000													3	42					0	0	1	0	0
MORF4L1	10933	broad.mit.edu	37	15	79183867	79183867	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:79183867C>T	ENST00000331268.5	+	8	712	c.508C>T	c.(508-510)Cag>Tag	p.Q170*	MORF4L1_ENST00000426013.2_Nonsense_Mutation_p.Q131*|MORF4L1_ENST00000558746.1_Nonsense_Mutation_p.Q104*|MORF4L1_ENST00000559345.1_Nonsense_Mutation_p.Q43*|MORF4L1_ENST00000558502.1_Nonsense_Mutation_p.Q43*|MORF4L1_ENST00000379535.4_Nonsense_Mutation_p.Q156*|MORF4L1_ENST00000561171.1_Intron	NM_206839.2	NP_996670.1	Q9UBU8	MO4L1_HUMAN	mortality factor 4 like 1	170	Interaction with RB1-1.|Sufficient for interaction with SIN3A.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding			breast(1)|large_intestine(3)|lung(4)|prostate(1)|urinary_tract(1)	10						TGAGACCCCTCAGCCTCCTCG	0.433000													12	54					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871895	149871895	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:149871895G>A	ENST00000369153.2	+	3	947	c.283G>A	c.(283-285)Gag>Aag	p.E95K	BOLA1_ENST00000369152.5_Missense_Mutation_p.E95K|BOLA1_ENST00000369150.1_Missense_Mutation_p.E95K|BOLA1_ENST00000476344.1_3'UTR			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	95						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			AGCGCTGGCCGAGGAGCTGGG	0.672000													7	45					0	0	1	0	0
LMNB1	4001	broad.mit.edu	37	5	126171934	126171934	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:126171934A>G	ENST00000261366.5	+	11	2100	c.1739A>G	c.(1738-1740)aAt>aGt	p.N580S	LMNB1_ENST00000460265.1_3'UTR	NM_001198557.1|NM_005573.3	NP_001185486.1|NP_005564.1	P20700	LMNB1_HUMAN	lamin B1	580	Tail.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		AGAGCATCCAATAGAAGCTGT	0.328000													15	105					0	0	1	0	0
TAF1A	9015	broad.mit.edu	37	1	222750892	222750892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:222750892C>A	ENST00000350027.4	-	5	652	c.499G>T	c.(499-501)Gaa>Taa	p.E167*	TAF1A_ENST00000366890.1_Nonsense_Mutation_p.E53*|TAF1A_ENST00000465263.1_5'UTR|TAF1A_ENST00000543857.1_Nonsense_Mutation_p.E167*|TAF1A_ENST00000352967.4_Nonsense_Mutation_p.E167*|TAF1A_ENST00000391882.1_Nonsense_Mutation_p.E53*	NM_001201536.1	NP_001188465.1	Q15573	TAF1A_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	167					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding			kidney(3)|large_intestine(3)|lung(11)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(131;0.0186)		GACGTATTTTCACCATGTCTC	0.383000													14	95					0.435327	0.435327	1	1	0
APBA3	9546	broad.mit.edu	37	19	3759710	3759710	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:3759710C>G	ENST00000316757.3	-	2	753	c.553G>C	c.(553-555)Gaa>Caa	p.E185Q		NM_004886.3	NP_004877.1	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 3	185					intracellular signal transduction|protein transport	intracellular|membrane	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGGCTCTTCAGGTGTGACT	0.662000													10	46					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211539656	211539656	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:211539656G>T	ENST00000233072.5	+	35	4328	c.4132G>T	c.(4132-4134)Gct>Tct	p.A1378S	CPS1_ENST00000430249.2_Missense_Mutation_p.A1384S|CPS1_ENST00000451903.2_Missense_Mutation_p.A927S	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1378					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTTGGTGTGGCTGAACAATT	0.343000													16	51					9.7654e-05	0.000100923	1	1	0
NRROS	375387	broad.mit.edu	37	3	196388126	196388126	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:196388126C>G	ENST00000328557.4	+	3	1815	c.1612C>G	c.(1612-1614)Ctc>Gtc	p.L538V		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GTTTGGGAATCTCAGGGACTT	0.567000													29	213					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507691	155507691	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:155507691G>T	ENST00000302053.3	-	5	968	c.890C>A	c.(889-891)tCt>tAt	p.S297Y	FGA_ENST00000403106.3_Missense_Mutation_p.S297Y	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	297					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGAGCTCCCAGAGTTCCAGCT	0.572000													13	98					1.49906e-05	1.57561e-05	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152716766	152716766	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:152716766C>G	ENST00000367255.5	-	51	8198	c.7597G>C	c.(7597-7599)Gaa>Caa	p.E2533Q	SYNE1_ENST00000448038.1_Missense_Mutation_p.E2540Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.E2540Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.E2533Q|SYNE1_ENST00000341594.5_Missense_Mutation_p.E2572Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2533					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTTCCATTTCATGGATCCAT	0.338000										HNSCC(10;0.0054)			4	87					0	0	1	0	0
GLB1L2	89944	broad.mit.edu	37	11	134240970	134240970	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:134240970C>T	ENST00000535456.2	+	13	1472	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F	GLB1L2_ENST00000529077.1_3'UTR|GLB1L2_ENST00000389881.3_Silent_p.F428F|GLB1L2_ENST00000339772.7_Silent_p.F428F	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	428					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GACAGTCCTTCGGGTACATTC	0.537000													4	77					0	0	1	0	0
QDPR	5860	broad.mit.edu	37	4	17506017	17506017	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:17506017T>G	ENST00000281243.5	-	3	459	c.280A>C	c.(280-282)Aat>Cat	p.N94H	QDPR_ENST00000428702.2_Missense_Mutation_p.N63H|QDPR_ENST00000513615.1_Missense_Mutation_p.N94H|QDPR_ENST00000508623.1_Missense_Mutation_p.N94H	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	94					dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	GATTTGGCATTGCCCCCGGCC	0.498000													7	40					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50339699	50339699	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:50339699C>A	ENST00000394697.2	+	14	2031	c.1691C>A	c.(1690-1692)tCc>tAc	p.S564Y	ADCY7_ENST00000566433.2_Missense_Mutation_p.S564Y|ADCY7_ENST00000538642.1_Missense_Mutation_p.S564Y|ADCY7_ENST00000537579.1_Silent_p.L430L|ADCY7_ENST00000254235.3_Missense_Mutation_p.S564Y			P51828	ADCY7_HUMAN	adenylate cyclase 7	564					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCCTGCTGCTCCAAGTCCGAT	0.662000													8	67					2.17888e-05	2.28044e-05	1	1	0
CARNS1	57571	broad.mit.edu	37	11	67191138	67191138	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:67191138C>A	ENST00000445895.2	+	9	2033	c.1919C>A	c.(1918-1920)cCa>cAa	p.P640Q	CARNS1_ENST00000531040.1_Missense_Mutation_p.P614Q|CARNS1_ENST00000524740.1_3'UTR|CARNS1_ENST00000307823.3_Missense_Mutation_p.P517Q|CARNS1_ENST00000423745.2_Missense_Mutation_p.P517Q			A5YM72	CRNS1_HUMAN	carnosine synthase 1	517	ATP-grasp.				carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)	11						CACCATGGCCCACCCTGGCCT	0.667000													3	16					0.150653	0.151266	1	1	0
WNT9A	7483	broad.mit.edu	37	1	228113135	228113135	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:228113135G>A	ENST00000272164.5	-	2	191	c.181C>T	c.(181-183)Cgg>Tgg	p.R61W	WNT9A_ENST00000497852.1_5'UTR	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	61					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				AGCTTCAGCCGGTCGCAGGCC	0.711000													3	18					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195515222	195515222	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:195515222T>C	ENST00000463781.3	-	2	3688	c.3229A>G	c.(3229-3231)Agc>Ggc	p.S1077G	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.S1077G	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	944					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAAGGCTGGTGACAGGA	0.572000													3	1					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194151043	194151043	+	Splice_Site	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:194151043A>G	ENST00000439040.1	-	25	3417	c.2624_splice	c.e25-1	p.Y876_splice	ATP13A3_ENST00000256031.4_Splice_Site_p.Y876_splice			Q9H7F0	AT133_HUMAN	ATPase type 13A3	876					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CCAACAAAATAACTAAGAAAC	0.264000													13	74					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159922313	159922313	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:159922313C>G	ENST00000368093.3	-	3	519	c.403G>C	c.(403-405)Gag>Cag	p.E135Q	SLAMF9_ENST00000466773.1_5'UTR|SLAMF9_ENST00000368092.3_Intron	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	135						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATCTGGGGCTCTGACAGCCAT	0.512000													22	94					0	0	1	0	0
SFTPB	6439	broad.mit.edu	37	2	85892750	85892750	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:85892750C>T	ENST00000393822.3	-	6	696	c.597G>A	c.(595-597)gcG>gcA	p.A199A	SFTPB_ENST00000409383.1_Silent_p.A199A|SFTPB_ENST00000342375.3_Silent_p.A187A|SFTPB_ENST00000519937.2_Silent_p.A187A			P07988	PSPB_HUMAN	surfactant protein B	187					organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)	16						GCCCAGGCCTCGCCTGGAGGG	0.677000													18	89					0	0	1	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478996	141478996	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:141478996C>T	ENST00000247881.2	+	1	755	c.708C>T	c.(706-708)ctC>ctT	p.L236L	SSBP1_ENST00000465582.1_Intron	NM_016944.1	NP_058640.1	Q9NYW5	TA2R4_HUMAN	taste receptor, type 2, member 4	236					sensory perception of taste	cilium membrane	taste receptor activity			endometrium(1)|large_intestine(4)|lung(2)	7	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TCTATTTCCTCATCCTCTACA	0.448000													15	80					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640702	57640702	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:57640702G>C	ENST00000254181.4	+	4	1113	c.659G>C	c.(658-660)aGa>aCa	p.R220T	USP29_ENST00000598197.1_Missense_Mutation_p.R220T	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	220					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.R220T(1)		breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAAAAGATAGAGATTTGAAA	0.363000													8	53					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45413348	45413348	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:45413348C>T	ENST00000267803.4	-	6	676	c.277G>A	c.(277-279)Gag>Aag	p.E93K	DUOXA1_ENST00000558996.1_Intron|DUOXA1_ENST00000559014.1_Missense_Mutation_p.E93K|DUOXA1_ENST00000430224.2_Intron|DUOXA1_ENST00000558422.1_Intron|DUOXA1_ENST00000560572.1_Missense_Mutation_p.E93K	NM_144565.2	NP_653166.2	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	93					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		CTGATCCACTCAGAACTGAAG	0.557000													9	44					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44377448	44377448	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:44377448C>A	ENST00000587539.1	-	3	917	c.918G>T	c.(916-918)aaG>aaT	p.K306N	ZNF404_ENST00000324394.6_Missense_Mutation_p.K304N	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				GAACAAAGGCCTTTTCACATT	0.383000													9	48					0.000978159	0.00100669	1	1	0
ACTR1B	10120	broad.mit.edu	37	2	98274969	98274969	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:98274969T>C	ENST00000289228.5	-	6	794	c.578A>G	c.(577-579)tAc>tGc	p.Y193C		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	193						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						GAGTCGGAGGTAGCGGGAGAC	0.602000													6	53					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36922648	36922648	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:36922648G>A	ENST00000373674.3	+	1	440	c.112G>A	c.(112-114)Gag>Aag	p.E38K		NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	38						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTGATGGTGGAGCTGCACAA	0.612000													12	57					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	46009654	46009654	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:46009654G>C	ENST00000296137.2	-	8	1377	c.1172C>G	c.(1171-1173)cCt>cGt	p.P391R	FYCO1_ENST00000535325.1_Missense_Mutation_p.P391R	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	391					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		ACTGGGAATAGGTTCTTGCCG	0.557000													24	158					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196198983	196198983	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:196198983G>A	ENST00000318037.3	-	6	2017	c.1423C>T	c.(1423-1425)Cac>Tac	p.H475Y		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	475					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding	p.H475D(1)		NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GCGCGTAAGTGATACTCATCT	0.458000													30	288					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159568119	159568119	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:159568119T>A	ENST00000307765.5	+	16	1773	c.1522T>A	c.(1522-1524)Ttg>Atg	p.L508M	RXFP1_ENST00000470033.1_Missense_Mutation_p.L475M|RXFP1_ENST00000343542.5_Missense_Mutation_p.L460M|RXFP1_ENST00000448688.2_Missense_Mutation_p.L403M|RXFP1_ENST00000460056.2_Missense_Mutation_p.L427M	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	508						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ATTTCTGACATTGGAAAAATA	0.388000													14	35					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134621926	134621926	+	Nonstop_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:134621926C>G	ENST00000368586.5	-	58	8247	c.8147G>C	c.(8146-8148)tGa>tCa	p.*2716S	TTC40_ENST00000263170.5_Nonstop_Mutation_p.*877S	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GTGGAACACTCAAATCAAAAA	0.577000													34	157					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5258057	5258057	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:5258057T>A	ENST00000372412.4	-	8	913	c.680A>T	c.(679-681)tAc>tTc	p.Y227F	PTPRS_ENST00000262963.6_Missense_Mutation_p.Y226F|PTPRS_ENST00000592099.1_Missense_Mutation_p.Y217F|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000587303.1_Missense_Mutation_p.Y226F|PTPRS_ENST00000357368.4_Missense_Mutation_p.Y226F|PTPRS_ENST00000353284.2_Missense_Mutation_p.Y217F|PTPRS_ENST00000348075.2_Missense_Mutation_p.Y217F|PTPRS_ENST00000588012.1_Missense_Mutation_p.Y217F			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	226	Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		AGGTGAGGAGTAGCGCACGCC	0.627000													54	70					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796485	62796485	+	RNA	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:62796485C>G	ENST00000582986.1	-	0	1435					NR_024386.1																						GGAAACATTTCAGAGCCTCCA	0.547000													3	34					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638590	113638590	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:113638590G>C	ENST00000361127.4	+	7	1096	c.898G>C	c.(898-900)Gaa>Caa	p.E300Q		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	300						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GAATGCTATTGAAAGAATCAG	0.458000													11	54					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143100949	143100949	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:143100949C>T	ENST00000316549.6	-	13	1685	c.1477G>A	c.(1477-1479)Gtg>Atg	p.V493M	SLC9A9-AS2_ENST00000490153.1_RNA	NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	493					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TCCAGGTCCACGCCAACTCTG	0.438000													11	162					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81248732	81248732	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr16:81248732G>C	ENST00000599697.1	-	3	530	c.531C>G	c.(529-531)atC>atG	p.I177M	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	177	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCTGGACCTGGATGACCTGCC	0.637000											OREG0023964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	12					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677480	37677480	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:37677480T>A	ENST00000532828.2	-	5	1210	c.959A>T	c.(958-960)cAc>cTc	p.H320L	ZNF585B_ENST00000531805.1_Missense_Mutation_p.H265L|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000312908.5_5'UTR|ZNF585B_ENST00000527838.1_3'UTR	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CACTCTTGTGTGAACACGTTG	0.388000													72	198					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83437633	83437633	+	Splice_Site	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:83437633C>G	ENST00000334574.8	-	9	1733	c.1553_splice	c.e9+1	p.E518_splice	FSD2_ENST00000541889.1_Splice_Site_p.E473_splice			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	518	Fibronectin type-III 2.									breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						ATGACTCACTCAGTTACACCC	0.532000													3	16					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99799674	99799674	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:99799674C>T	ENST00000259470.5	-	4	505	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K	CTSV_ENST00000479932.1_5'UTR|CTSV_ENST00000538255.1_Missense_Mutation_p.E86K	NM_001333.3	NP_001324.2			cathepsin V																		CTGAATTCTTCATTGGTCTTC	0.423000													7	87					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579932	179579932	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:179579932G>A	ENST00000589042.1	-	90	26205	c.25981C>T	c.(25981-25983)Cac>Tac	p.H8661Y	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.H8344Y|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.H7417Y|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8344	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTCAAGGTGAACATCAGCT	0.413000													11	101					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539623	17539623	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:17539623G>C	ENST00000229922.2	+	8	1292	c.760G>C	c.(760-762)Gag>Cag	p.E254Q	CAP2_ENST00000378990.2_Missense_Mutation_p.E228Q|CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.E190Q|CAP2_ENST00000489374.1_Missense_Mutation_p.E142Q	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	254					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding	p.E254K(1)		breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AGGCAAAAAAGAGGAATCTTC	0.517000													22	81					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50685661	50685661	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:50685661C>T	ENST00000230658.7	+	4	1245	c.660C>T	c.(658-660)ctC>ctT	p.L220L	ISL1_ENST00000505475.2_3'UTR|ISL1_ENST00000511384.1_Silent_p.L220L	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	220					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				TGACGGGCCTCAGTCCCCGTG	0.572000													5	52					0	0	1	0	0
RTN4	57142	broad.mit.edu	37	2	55254574	55254574	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:55254574G>A	ENST00000337526.6	-	3	904	c.661C>T	c.(661-663)Caa>Taa	p.Q221*	RTN4_ENST00000394611.2_Nonsense_Mutation_p.Q15*|RTN4_ENST00000357732.4_Intron|RTN4_ENST00000357376.3_Nonsense_Mutation_p.Q15*|RTN4_ENST00000354474.6_Intron|RTN4_ENST00000317610.7_Intron|RTN4_ENST00000405240.1_Nonsense_Mutation_p.Q15*|RTN4_ENST00000404909.1_Nonsense_Mutation_p.Q15*|RTN4_ENST00000402434.2_Intron	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	221					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						AAATCCTCTTGACCAGCCGAA	0.448000													16	70					0	0	1	0	0
GCC1	79571	broad.mit.edu	37	7	127224348	127224348	+	Missense_Mutation	SNP	G	G	A	rs139439757	byFrequency	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:127224348G>A	ENST00000321407.2	-	1	1313	c.889C>T	c.(889-891)Cgt>Tgt	p.R297C	GCC1_ENST00000497650.1_Intron	NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	297						Golgi membrane|plasma membrane	protein binding			breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TCCACCTCACGGGTCAGCTGC	0.542000											OREG0003809	type=REGULATORY REGION|Gene=GCC1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	46					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	419668	419668	+	RNA	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:419668G>C	ENST00000451020.2	-	0	1370					NR_002451.2																						AAGGTAGCCTGAGAGAGGCTG	0.448000													7	22					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124811010	124811010	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:124811010C>G	ENST00000423114.2	-	11	1824	c.1825G>C	c.(1825-1827)Gat>Cat	p.D609H	SLC12A8_ENST00000430155.2_Missense_Mutation_p.D381H|SLC12A8_ENST00000469902.1_Missense_Mutation_p.D580H|SLC12A8_ENST00000393469.4_Missense_Mutation_p.D580H|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000465475.1_Intron			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	580					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CTCCAGACATCTTGTTCTTGG	0.418000													9	43					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53493743	53493743	+	Splice_Site	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:53493743G>A	ENST00000488965.1	+	2	173	c.126_splice	c.e2+1	p.E42_splice	SCP2_ENST00000430330.2_Splice_Site_p.E39_splice|SCP2_ENST00000528311.1_Splice_Site_p.E365_splice|SCP2_ENST00000408941.3_Splice_Site_p.E42_splice|SCP2_ENST00000407246.2_Splice_Site_p.E422_splice|SCP2_ENST00000435345.2_Splice_Site_p.E42_splice|SCP2_ENST00000371509.4_Splice_Site_p.E402_splice|SCP2_ENST00000371514.3_Splice_Site_p.E446_splice			P22307	NLTP_HUMAN	sterol carrier protein 2	446					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						AACTTGAAGAGGTAAGATTTA	0.388000													3	18					0	0	1	0	0
KLRG1	10219	broad.mit.edu	37	12	9142258	9142258	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:9142258G>C	ENST00000266551.4	+	1	42	c.27G>C	c.(25-27)atG>atC	p.M9I	KLRG1_ENST00000538029.1_Intron|KLRG1_ENST00000356986.3_Missense_Mutation_p.M9I|RP11-259O18.4_ENST00000545706.1_RNA	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	9					cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						TTTATTCCATGTTAGAGTTGC	0.413000													7	62					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20055047	20055047	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:20055047C>T	ENST00000276390.2	+	1	170	c.130C>T	c.(130-132)Cgc>Tgc	p.R44C		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	44					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		CTCCCAGCCTCGCCTCAGTGA	0.652000													3	10					0	0	1	0	0
ENOPH1	58478	broad.mit.edu	37	4	83378153	83378153	+	Nonsense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:83378153C>G	ENST00000273920.3	+	5	876	c.608C>G	c.(607-609)tCa>tGa	p.S203*	ENOPH1_ENST00000509635.1_Nonsense_Mutation_p.S115*	NM_021204.3	NP_067027.1	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	203					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|skin(1)	13						ATTGGGTGCTCAACCAACAAC	0.393000													9	58					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													9	45					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107430085	107430085	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:107430085C>G	ENST00000340010.5	-	6	803	c.619G>C	c.(619-621)Gag>Cag	p.E207Q	SLC26A3_ENST00000422236.2_Missense_Mutation_p.E172Q	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	207					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATGAGGGACTCAGACAGGTAT	0.443000													4	16					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88204527	88204527	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:88204527C>T	ENST00000357081.3	-	20	2782	c.2638G>A	c.(2638-2640)Gaa>Aaa	p.E880K	AGTPBP1_ENST00000376083.3_Missense_Mutation_p.E840K|AGTPBP1_ENST00000432218.1_Intron|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376109.3_Missense_Mutation_p.E892K			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	880					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						GACAGGGTTTCACATAACACA	0.353000													8	58					0	0	1	0	0
CCDC41	51134	broad.mit.edu	37	12	94769780	94769780	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:94769780G>A	ENST00000397809.5	-	8	1364	c.815C>T	c.(814-816)tCa>tTa	p.S272L	CCDC41_ENST00000397807.2_Missense_Mutation_p.S239L|CCDC41_ENST00000549352.1_5'UTR|CCDC41_ENST00000547575.1_Missense_Mutation_p.S272L|CCDC41_ENST00000339839.5_Missense_Mutation_p.S272L	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	264										breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						TAAATTAGCTGATTGTTTTTC	0.259000													4	42					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26239822	26239822	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr22:26239822C>G	ENST00000335473.7	+	18	3579	c.3329C>G	c.(3328-3330)tCg>tGg	p.S1110W	MYO18B_ENST00000536101.1_Missense_Mutation_p.S1110W|MYO18B_ENST00000407587.2_Missense_Mutation_p.S1111W	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1110	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCCAACCTCTCGGCCCTGGAT	0.607000													10	47					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277857	152277857	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:152277857C>T	ENST00000368799.1	-	3	9540	c.9505G>A	c.(9505-9507)Gaa>Aaa	p.E3169K	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3169	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGATTGTTCCTCATTACGT	0.552000									Ichthyosis				5	411					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145074987	145074987	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:145074987C>T	ENST00000369345.4	-	2	521	c.307G>A	c.(307-309)Ggc>Agc	p.G103S	PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369359.4_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTTCCAGGCCAAAGCAAAGG	0.453000			T	PDGFRB	MPD								6	38					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39726736	39726736	+	Silent	SNP	C	C	T	rs148846158	byFrequency	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:39726736C>T	ENST00000395670.3	-	19	3080	c.2661G>A	c.(2659-2661)gcG>gcA	p.A887A	KIF21A_ENST00000361418.5_Silent_p.A887A|KIF21A_ENST00000541463.2_Silent_p.A851A|KIF21A_ENST00000544797.2_Silent_p.A874A|KIF21A_ENST00000361961.3_Silent_p.A874A			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	887					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CCTGGACTCTCGCCACAGGAA	0.488000													8	35					0	0	1	0	0
C1orf56	54964	broad.mit.edu	37	1	151021313	151021313	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:151021313C>T	ENST00000368926.5	+	1	1098	c.990C>T	c.(988-990)ttC>ttT	p.F330F	C1orf56_ENST00000465135.1_3'UTR	NM_017860.3	NP_060330.2	Q9BUN1	CA056_HUMAN	chromosome 1 open reading frame 56	330						extracellular region				endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTCAGTGTTCACAGAGATGC	0.532000											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	67					0	0	1	0	0
LRRC73	221424	broad.mit.edu	37	6	43475308	43475308	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:43475308C>G	ENST00000372441.1	-	5	1666	c.766G>C	c.(766-768)Gag>Cag	p.E256Q		NM_001012974.1	NP_001012992.1	Q5JTD7	CF154_HUMAN	leucine rich repeat containing 73	256	Poly-Glu.																TCCTCTCCCTCAGAGAGGAGG	0.607000													5	53					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82336770	82336770	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:82336770G>C	ENST00000329713.4	-	2	876	c.441C>G	c.(439-441)ctC>ctG	p.L147L	MEX3B_ENST00000558133.1_3'UTR	NM_032246.3	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	147					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CCGCGCCGTTGAGTGCCGTGT	0.672000													12	44					0	0	1	0	0
RAC2	5880	broad.mit.edu	37	22	37637671	37637671	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr22:37637671G>C	ENST00000249071.6	-	2	184	c.63C>G	c.(61-63)atC>atG	p.I21M	RAC2_ENST00000405484.1_Missense_Mutation_p.I14M|RAC2_ENST00000401529.3_Missense_Mutation_p.I21M|RAC2_ENST00000406508.1_De_novo_Start_InFrame	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	21					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding	p.I21M(1)		breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGGTGTAGCTGATGAGAAGGC	0.617000													15	73					0	0	1	0	0
MSC	9242	broad.mit.edu	37	8	72754970	72754970	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:72754970C>T	ENST00000325509.4	-	2	836	c.547G>A	c.(547-549)Gtg>Atg	p.V183M	RP11-383H13.1_ENST00000521467.1_Intron|MSC_ENST00000518440.1_5'UTR	NM_005098.3	NP_005089.2	O60682	MUSC_HUMAN	musculin	183					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(4)|skin(2)	26	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CCCGAGACCACGAATGGCCAT	0.478000													49	337					0	0	1	0	0
MDM2	4193	broad.mit.edu	37	12	69229700	69229700	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:69229700C>A	ENST00000462284.1	+	9	1078	c.776C>A	c.(775-777)tCt>tAt	p.S259Y	MDM2_ENST00000348801.2_Missense_Mutation_p.S53Y|MDM2_ENST00000299252.4_Missense_Mutation_p.S83Y|MDM2_ENST00000258149.5_Missense_Mutation_p.S198Y|MDM2_ENST00000478070.1_Intron|MDM2_ENST00000428863.2_Missense_Mutation_p.S58Y|MDM2_ENST00000393410.1_Intron|MDM2_ENST00000393412.3_Intron|MDM2_ENST00000393413.3_Intron|MDM2_ENST00000360430.2_Missense_Mutation_p.S58Y|MDM2_ENST00000356290.4_Missense_Mutation_p.S83Y|MDM2_ENST00000350057.5_Missense_Mutation_p.S228Y|MDM2_ENST00000517852.1_Intron|MDM2_ENST00000545204.1_Intron|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000258148.7_Missense_Mutation_p.S204Y|MDM2_ENST00000540827.1_Missense_Mutation_p.S58Y	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	253	ARF-binding.|Asp/Glu-rich (acidic).|Interaction with MTBP (By similarity).|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GAAGTTGAATCTCTCGACTCA	0.358000			A		"""sarcoma, glioma, colorectal, other"""								25	37					2.79863e-10	3.06546e-10	1	1	0
OXTR	5021	broad.mit.edu	37	3	8794849	8794849	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:8794849G>C	ENST00000316793.3	-	4	1608	c.984C>G	c.(982-984)atC>atG	p.I328M	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	328					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	ACAGCATGTAGATCCAGGGGT	0.612000													12	46					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50776913	50776913	+	Splice_Site	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:50776913C>G	ENST00000216923.4	-	5	861	c.511_splice	c.e5-1	p.G171_splice	ZFP64_ENST00000477786.1_5'UTR|ZFP64_ENST00000371518.2_Splice_Site_p.G171_splice|ZFP64_ENST00000371515.4_Splice_Site_p.G169_splice|ZFP64_ENST00000361387.2_Splice_Site_p.G171_splice|ZFP64_ENST00000346617.4_Splice_Site_p.G117_splice	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						GGGTTTGTCTCCTTCAAACAC	0.458000													4	128					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50758384	50758384	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:50758384C>T	ENST00000404971.1	-	12	3787	c.2448G>A	c.(2446-2448)gtG>gtA	p.V816V	NRXN1_ENST00000406859.3_Silent_p.V776V|NRXN1_ENST00000401669.2_Silent_p.V776V|NRXN1_ENST00000405472.3_Silent_p.V768V|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Silent_p.V776V|NRXN1_ENST00000402717.3_Silent_p.V768V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	776	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCGTCAGTTTCACACGTCCTG	0.483000													4	34					0	0	1	0	0
PAFAH1B1	5048	broad.mit.edu	37	17	2585085	2585085	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:2585085G>C	ENST00000397195.5	+	11	1673	c.1222G>C	c.(1222-1224)Gag>Cag	p.E408Q	PAFAH1B1_ENST00000397193.3_3'UTR|PAFAH1B1_ENST00000451360.2_Missense_Mutation_p.E203Q	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	408	Interaction with DCX.|Interaction with NDEL1 (By similarity).|Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						AAAAGTGTGGGAGTGCCGTTG	0.448000													7	20					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104198	53104198	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:53104198C>A	ENST00000408890.4	+	1	850	c.834C>A	c.(832-834)tgC>tgA	p.C278*		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	278										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GCGGCAGCTGCAGTAGGGTCT	0.622000													10	71					1.58986e-06	1.69631e-06	1	1	0
NR2C2AP	126382	broad.mit.edu	37	19	19313613	19313613	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:19313613C>T	ENST00000331552.6	-	2	479	c.116G>A	c.(115-117)tGg>tAg	p.W39*	NR2C2AP_ENST00000544883.1_Nonsense_Mutation_p.W39*|NR2C2AP_ENST00000590907.2_Intron|NR2C2AP_ENST00000420605.2_Nonsense_Mutation_p.W39*|NR2C2AP_ENST00000538165.2_Nonsense_Mutation_p.W39*	NM_176880.4	NP_795361.1	Q86WQ0	NR2CA_HUMAN	nuclear receptor 2C2-associated protein	39					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				breast(1)|cervix(1)|kidney(2)|ovary(1)	5			Epithelial(12;0.00235)			GTCTGAGTTCCAACATGTCTC	0.542000													9	49					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028269	45028269	+	RNA	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:45028269G>A	ENST00000454753.1	-	0	500							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				TGCCTGGGCTGACTGCAATGG	0.527000													10	64					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137136	40137136	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:40137136G>C	ENST00000278198.2	-	2	2670	c.707C>G	c.(706-708)cCt>cGt	p.P236R	LRRC4C_ENST00000527150.1_Missense_Mutation_p.P236R|LRRC4C_ENST00000530763.1_Missense_Mutation_p.P236R|LRRC4C_ENST00000528697.1_Missense_Mutation_p.P236R			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	236					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GAAAGAGCCAGGCCTGATGGC	0.458000													33	63					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960737	29960737	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:29960737G>C	ENST00000253381.2	+	2	169	c.136G>C	c.(136-138)Gat>Cat	p.D46H		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	46					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			AGCAGTGAAAGATACATGCAA	0.453000													10	77					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39079378	39079378	+	Silent	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:39079378C>A	ENST00000331366.5	-	16	1281	c.1185G>T	c.(1183-1185)ggG>ggT	p.G395G	CPNE8_ENST00000360449.3_Silent_p.G383G|CPNE8_ENST00000538596.2_Silent_p.G64G	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	395	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CCTCCATGACCCCCTCAATGC	0.388000													13	73					5.01169e-05	5.20121e-05	1	1	0
USP34	9736	broad.mit.edu	37	2	61546322	61546322	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:61546322G>C	ENST00000398571.2	-	22	3230	c.3154C>G	c.(3154-3156)Ctt>Gtt	p.L1052V		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1052					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCCAGGAAAAGATGTTTGTAG	0.323000													7	84					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58152590	58152590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:58152590C>T	ENST00000544273.1	+	5	1099	c.772C>T	c.(772-774)Cag>Tag	p.Q258*	ZNF211_ENST00000254182.7_Nonsense_Mutation_p.Q237*|ZNF211_ENST00000299871.5_Nonsense_Mutation_p.Q311*|ZNF211_ENST00000391703.3_Nonsense_Mutation_p.Q185*|ZNF211_ENST00000347302.3_Nonsense_Mutation_p.Q246*|ZNF211_ENST00000420680.1_Nonsense_Mutation_p.Q250*|ZNF211_ENST00000240731.4_Nonsense_Mutation_p.Q259*|ZNF211_ENST00000541801.1_Nonsense_Mutation_p.Q237*			Q13398	ZN211_HUMAN	zinc finger protein 211	246						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACACTTGTTCAGGACCAGAG	0.433000													20	97					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80843596	80843596	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:80843596G>A	ENST00000533983.1	+	10	1240	c.901G>A	c.(901-903)Gtg>Atg	p.V301M	ARNT2_ENST00000527771.1_Missense_Mutation_p.V301M|ARNT2_ENST00000303329.4_Missense_Mutation_p.V312M			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	312					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			ATATTGCCTCGTGGCAATTGG	0.438000													22	51					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26513716	26513716	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:26513716G>A	ENST00000531191.1	+	14	1599	c.592G>A	c.(592-594)Gat>Aat	p.D198N	CNKSR1_ENST00000374253.5_Missense_Mutation_p.D463N|CNKSR1_ENST00000361530.6_Missense_Mutation_p.D456N			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	463	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTGGACATGATCAGAAGAA	0.527000													9	26					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11765324	11765324	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:11765324C>A	ENST00000381486.2	+	24	4492	c.4192C>A	c.(4192-4194)Ccc>Acc	p.P1398T	GREB1_ENST00000234142.5_Missense_Mutation_p.P1398T|GREB1_ENST00000396123.1_Missense_Mutation_p.P396T	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1398						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCTTAGCGACCCCTGGCCAGA	0.448000													95	188					1.19196e-48	1.35053e-48	1	1	0
CD68	968	broad.mit.edu	37	17	7484303	7484303	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:7484303C>G	ENST00000250092.6	+	5	1061	c.850C>G	c.(850-852)Ctt>Gtt	p.L284V	CD68_ENST00000380498.6_Missense_Mutation_p.L257V	NM_001251.2	NP_001242.2	P34810	CD68_HUMAN	CD68 molecule	284						endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane				endometrium(1)|lung(1)|skin(1)	3						GAGCATCATTCTTTCACCAGC	0.572000													13	84					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90572749	90572749	+	RNA	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:90572749A>G	ENST00000551025.1	+	0	2758							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTCAAACAGTAGAACTCACAA	0.368000													19	65					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551779	248551779	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:248551779C>A	ENST00000355728.2	+	1	870	c.870C>A	c.(868-870)taC>taA	p.Y290*		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTCATCTACAGTCTGAGGA	0.443000													16	51					5.01169e-05	5.20121e-05	1	1	0
EPN1	29924	broad.mit.edu	37	19	56200300	56200300	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:56200300C>G	ENST00000411543.2	+	5	1423	c.876C>G	c.(874-876)agC>agG	p.S292R	EPN1_ENST00000270460.6_Missense_Mutation_p.S181R|EPN1_ENST00000085079.7_Missense_Mutation_p.S181R|EPN1_ENST00000591743.1_3'UTR	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	181	8 X 3 AA repeats of [ED]-P-W.|Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CGCAGAGCAGCGGGGAGGAGG	0.711000													6	6					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93952390	93952390	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:93952390G>A	ENST00000412050.4	-	3	1097	c.1009C>T	c.(1009-1011)Cgg>Tgg	p.R337W	CPEB3_ENST00000265997.4_Missense_Mutation_p.R337W	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	337							nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				GGCCTACTCCGGTCCTAAGAA	0.358000													5	28					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62577838	62577838	+	Missense_Mutation	SNP	T	T	C	rs145678786	byFrequency	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:62577838T>C	ENST00000389204.4	-	6	735	c.650A>G	c.(649-651)aAg>aGg	p.K217R	ASPH_ENST00000522835.1_Intron|ASPH_ENST00000517847.2_Intron|ASPH_ENST00000445642.3_Intron|ASPH_ENST00000522603.1_Missense_Mutation_p.K202R|ASPH_ENST00000517856.1_Intron|ASPH_ENST00000356457.5_Intron|ASPH_ENST00000518068.1_Intron|ASPH_ENST00000517903.1_Intron|ASPH_ENST00000379454.4_Intron|ASPH_ENST00000541428.1_Intron	NM_020164.4	NP_064549.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	0	Glu-rich.				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	GGTATTTCCCTTTGTTAAGTG	0.378000													44	103					0	0	1	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10418965	10418965	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:10418965C>T	ENST00000403903.3	-	1	1591	c.393G>A	c.(391-393)ctG>ctA	p.L131L	CTD-2369P2.10_ENST00000452032.2_3'UTR|ZGLP1_ENST00000403352.1_Silent_p.L47L|FDX1L_ENST00000541276.1_3'UTR	NM_001103167.1	NP_001096637.1	P0C6A0	ZGLP1_HUMAN	zinc finger, GATA-like protein 1	131					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|ovary(1)	6						GGCAGGGGTTCAGCTGTTTCC	0.637000													9	21					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194151922	194151922	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:194151922C>G	ENST00000439040.1	-	23	3246	c.2455G>C	c.(2455-2457)Gag>Cag	p.E819Q	ATP13A3_ENST00000256031.4_Missense_Mutation_p.E819Q			Q9H7F0	AT133_HUMAN	ATPase type 13A3	819					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGAAGATCCTCTAAGCTATCA	0.338000													9	114					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6843175	6843175	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:6843175C>G	ENST00000304076.2	+	21	2038	c.1944C>G	c.(1942-1944)ctC>ctG	p.L648L	VAV1_ENST00000539284.1_Silent_p.L573L|VAV1_ENST00000596764.1_Silent_p.L638L|VAV1_ENST00000599806.1_Silent_p.L615L|VAV1_ENST00000602142.1_Silent_p.L670L	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	670	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CTGTTCATCTCTGGTGAGTAG	0.488000													33	91					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767715	121767715	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:121767715G>C	ENST00000261367.7	+	8	2803	c.1375G>C	c.(1375-1377)Gca>Cca	p.A459P	SNCAIP_ENST00000261368.8_Missense_Mutation_p.A412P|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.A459P|SNCAIP_ENST00000379536.2_Missense_Mutation_p.A352P|SNCAIP_ENST00000379538.3_Missense_Mutation_p.A46P|SNCAIP_ENST00000503116.2_Missense_Mutation_p.A459P|SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	412					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGAAGCCATTGCAGAACTGAG	0.418000													3	34					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52702585	52702585	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:52702585C>G	ENST00000356770.4	-	3	315	c.313G>C	c.(313-315)Gag>Cag	p.E105Q	PBRM1_ENST00000296302.7_Missense_Mutation_p.E105Q|PBRM1_ENST00000337303.4_Missense_Mutation_p.E105Q|PBRM1_ENST00000409114.3_Missense_Mutation_p.E105Q|PBRM1_ENST00000409767.1_Missense_Mutation_p.E105Q|PBRM1_ENST00000394830.3_Missense_Mutation_p.E105Q|PBRM1_ENST00000410007.1_Missense_Mutation_p.E105Q|PBRM1_ENST00000409057.1_Missense_Mutation_p.E105Q			Q86U86	PB1_HUMAN	polybromo 1	105	Bromo 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCATCATACTCTTCCATTTTT	0.299000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								8	35					0	0	1	0	0
FAM83D	81610	broad.mit.edu	37	20	37580315	37580315	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:37580315C>A	ENST00000217429.4	+	4	1041	c.1000C>A	c.(1000-1002)Cac>Aac	p.H334N		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	304					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				ACTCCTGTCTCACTTCCAGAG	0.532000													4	111					0.00909568	0.00920751	1	1	0
ZNF385D	79750	broad.mit.edu	37	3	21792472	21792472	+	Translation_Start_Site	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:21792472G>A	ENST00000281523.2	-	0	455				ZNF385D_ENST00000494118.1_Intron	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D							nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						AGGCTGGCACGTAGAGCAGAG	0.557000													5	25					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66188671	66188671	+	Silent	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:66188671A>G	ENST00000360689.5	+	8	2741	c.1014A>G	c.(1012-1014)ccA>ccG	p.P338P	FUT8_ENST00000557164.1_Silent_p.P175P|FUT8_ENST00000394586.2_Silent_p.P338P|FUT8_ENST00000358307.2_Silent_p.P209P|FUT8_ENST00000417683.1_Intron|FUT8_ENST00000394585.1_Silent_p.P338P	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	338					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TGATCCGCCCACAGCCTTGGC	0.468000													17	75					0	0	1	0	0
ZNF501	115560	broad.mit.edu	37	3	44776052	44776052	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:44776052G>A	ENST00000396048.2	+	3	576	c.139G>A	c.(139-141)Gag>Aag	p.E47K		NM_001258280.1|NM_145044.3	NP_001245209.1|NP_659481.2	Q96CX3	ZN501_HUMAN	zinc finger protein 501	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		TCACAGAGGAGAGAAGCCCTA	0.413000													18	32					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6864840	6864840	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:6864840T>G	ENST00000307659.5	+	7	3186	c.2731T>G	c.(2731-2733)Tat>Gat	p.Y911D	KIAA0232_ENST00000425103.1_Missense_Mutation_p.Y911D	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	911							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						TGGTGGTGATTATACAACACC	0.448000													14	41					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36263163	36263163	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:36263163G>A	ENST00000394571.2	+	5	737	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	PNPLA1_ENST00000312917.5_Missense_Mutation_p.R160Q|PNPLA1_ENST00000388715.3_Missense_Mutation_p.R151Q	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	246					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TACTACTACCGAGGGTACGAG	0.582000													9	82					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875642	33875642	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:33875642C>T	ENST00000374408.3	-	4	1036	c.940G>A	c.(940-942)Gag>Aag	p.E314K		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	314										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AGCGGGTCCTCACCGCCACAG	0.667000													5	10					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201515727	201515727	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:201515727G>C	ENST00000374700.2	+	26	3119	c.2878G>C	c.(2878-2880)Gat>Cat	p.D960H	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	960					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CAAGGAAATTGATCAAACACC	0.433000													11	68					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2613674	2613674	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:2613674G>A	ENST00000399634.1	+	8	1186	c.1186G>A	c.(1186-1188)Gtt>Att	p.V396I	CACNA1C_ENST00000399641.1_Missense_Mutation_p.V396I|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000399644.1_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000399597.1_Intron|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000399638.1_Intron|CACNA1C_ENST00000399617.1_Missense_Mutation_p.V396I|CACNA1C_ENST00000347598.4_Intron|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000406454.3_Missense_Mutation_p.V396I|CACNA1C_ENST00000480911.1_Intron|CACNA1C_ENST00000399603.1_Missense_Mutation_p.V396I|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000402845.3_Intron	NM_001167625.1	NP_001161097.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	396					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATCCTTTTTCGTTCTAAATCT	0.488000													14	72					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819433	43819433	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:43819433G>A	ENST00000382031.1	+	5	6507	c.6476G>A	c.(6475-6477)aGg>aAg	p.R2159K	MAP1A_ENST00000300231.5_Missense_Mutation_p.R1921K|MAP1A_ENST00000399453.1_Missense_Mutation_p.R1921K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1921						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GAAGAAGGTAGGGCTGAGGCT	0.602000													14	53					0	0	1	0	0
PRRG2	5639	broad.mit.edu	37	19	50093194	50093194	+	Missense_Mutation	SNP	C	C	G	rs139807476		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:50093194C>G	ENST00000246794.5	+	6	644	c.475C>G	c.(475-477)Ctg>Gtg	p.L159V	PRRG2_ENST00000596700.1_3'UTR	NM_000951.2	NP_000942.1	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	159						extracellular region|integral to plasma membrane	calcium ion binding			lung(1)|skin(1)|soft_tissue(1)	3		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		TTTGAACCCTCTGGGcccacc	0.642000													9	34					0	0	1	0	0
C20orf27	54976	broad.mit.edu	37	20	3736145	3736145	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:3736145T>C	ENST00000379772.3	-	4	1082	c.272A>G	c.(271-273)aAg>aGg	p.K91R	C20orf27_ENST00000217195.8_Missense_Mutation_p.K116R	NM_001258429.1	NP_001245358.1	Q9GZN8	CT027_HUMAN	chromosome 20 open reading frame 27	91										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|urinary_tract(1)	7						GCTGAGGAGCTTGAGGTGCAG	0.612000													6	23					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516530	195516530	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:195516530G>C	ENST00000463781.3	-	2	2380	c.1921C>G	c.(1921-1923)Caa>Gaa	p.Q641E	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.Q641E	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	646					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGCGGGGCTTGAGTGTGACCC	0.512000													24	222					0	0	1	0	0
EIF2B4	8890	broad.mit.edu	37	2	27587687	27587687	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:27587687C>A	ENST00000493344.2	-	11	1645	c.1333G>T	c.(1333-1335)Gcc>Tcc	p.A445S	EIF2B4_ENST00000445933.2_Missense_Mutation_p.A423S|EIF2B4_ENST00000451130.2_Missense_Mutation_p.A444S|EIF2B4_ENST00000347454.4_Missense_Mutation_p.A424S|AC074117.10_ENST00000412749.1_RNA			Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	424					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(5)|skin(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCAGGGCTAACTGTGCT	0.512000													10	50					3.07112e-06	3.26265e-06	1	1	0
ZNF737	100129842	broad.mit.edu	37	19	20727911	20727911	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:20727911C>G	ENST00000427401.4	-	4	1192	c.1098G>C	c.(1096-1098)gaG>gaC	p.E366D		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	366					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGTAGGGTTTCTCTCCACTAT	0.403000													8	54					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111766608	111766608	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:111766608C>G	ENST00000452346.2	+	7	756	c.753C>G	c.(751-753)ttC>ttG	p.F251L	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.F125L			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	251	CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTCAGTACTTCTATGCAGAGC	0.433000													8	36					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103447296	103447296	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:103447296C>T	ENST00000361246.2	-	8	1242	c.954G>A	c.(952-954)caG>caA	p.Q318Q		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	318	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AGATCAGTCTCTGGATGAGGT	0.488000													21	63					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347739	140347739	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140347739A>G	ENST00000289269.5	+	1	1920	c.1388A>G	c.(1387-1389)aAt>aGt	p.N463S	PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		463	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGACATCAATGACAATCCA	0.517000													25	144					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62298456	62298456	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:62298456C>T	ENST00000378024.4	-	5	3707	c.3433G>A	c.(3433-3435)Gaa>Aaa	p.E1145K	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1145					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ACATCCACTTCTGGGCCCTCG	0.552000													31	176					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39055709	39055709	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:39055709G>C	ENST00000355481.4	+	90	12851	c.12720G>C	c.(12718-12720)caG>caC	p.Q4240H	RYR1_ENST00000360985.3_Missense_Mutation_p.Q4240H|RYR1_ENST00000359596.3_Missense_Mutation_p.Q4245H	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4245					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGAGATGCAGATCGCCGCGC	0.687000													2	2					0	0	1	0	0
MLLT10	8028	broad.mit.edu	37	10	22015240	22015240	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:22015240C>T	ENST00000377072.3	+	16	2342	c.1994C>T	c.(1993-1995)tCa>tTa	p.S665L	MLLT10_ENST00000307729.7_Missense_Mutation_p.S649L|MLLT10_ENST00000446906.2_Missense_Mutation_p.S649L|MLLT10_ENST00000377059.3_Missense_Mutation_p.S649L	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	665	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						AGATCAAATTCATCAATGGCA	0.328000			T	"""MLL, PICALM, CDK6"""	AL								20	198					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95157581	95157581	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:95157581G>A	ENST00000325885.5	+	3	1015	c.944G>A	c.(943-945)gGg>gAg	p.G315E	ASB4_ENST00000428113.1_Missense_Mutation_p.G315E	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	315					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TTGAACCATGGGGCTGCCCGA	0.562000											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	55					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78781045	78781045	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:78781045G>A	ENST00000258886.8	+	16	2157	c.2008G>A	c.(2008-2010)Gaa>Aaa	p.E670K		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	670							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TAGTCGAGAAGAAGTTCATCG	0.328000													16	49					0	0	1	0	0
C14orf79	122616	broad.mit.edu	37	14	105453189	105453189	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:105453189G>C	ENST00000547315.1	+	1	1060	c.421G>C	c.(421-423)Gag>Cag	p.E141Q	C14orf79_ENST00000549584.1_3'UTR	NM_174891.3	NP_777551.2	Q96F83	CN079_HUMAN	chromosome 14 open reading frame 79	141										breast(1)|endometrium(1)|lung(1)	3		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			CCCACCTTCTGAGGTATTTCT	0.587000													11	66					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4930834	4930834	+	RNA	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:4930834C>G	ENST00000592666.1	+	0	1091							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CCCTGCAGCTCCACGTCCAGG	0.647000													18	95					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30024699	30024699	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:30024699G>A	ENST00000346128.6	-	15	2429	c.1955C>T	c.(1954-1956)cCa>cTa	p.P652L	TJP1_ENST00000545208.2_Missense_Mutation_p.P652L|TJP1_ENST00000356107.6_Missense_Mutation_p.P652L|TJP1_ENST00000400011.2_Missense_Mutation_p.P656L	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	652	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ATCAGCTATTGGTCCAAAAAT	0.373000													27	94					0	0	1	0	0
AP5B1	91056	broad.mit.edu	37	11	65545761	65545761	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:65545761G>T	ENST00000532090.2	-	2	2413	c.2203C>A	c.(2203-2205)Ccc>Acc	p.P735T		NM_138368.4	NP_612377.4	Q2VPB7	YK046_HUMAN	adaptor-related protein complex 5, beta 1 subunit	678							protein binding			lung(1)	1						AGCCGTGCGGGGGCCGGGCAT	0.647000													7	51					1.12685e-05	1.18692e-05	1	1	0
CENPE	1062	broad.mit.edu	37	4	104079981	104079981	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:104079981C>T	ENST00000265148.3	-	23	2753	c.2664G>A	c.(2662-2664)gaG>gaA	p.E888E	CENPE_ENST00000380026.3_Silent_p.E863E	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	888					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GCTGTTCCATCTCATTTAGTC	0.363000													10	31					0	0	1	0	0
ABHD14B	84836	broad.mit.edu	37	3	52003451	52003451	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:52003451C>T	ENST00000315877.10	-	6	1311	c.618G>A	c.(616-618)ggG>ggA	p.G206G	ABHD14B_ENST00000395008.2_Silent_p.G208G|ABHD14B_ENST00000461108.1_3'UTR|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000487005.1_5'UTR|ABHD14B_ENST00000361143.5_Silent_p.G208G|ABHD14B_ENST00000483233.1_Silent_p.G208G|ABHD14B_ENST00000525795.1_Silent_p.G208G			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	208						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		TTCACTGGAGCCCCTGCAGGA	0.632000													18	55					0	0	1	0	0
HNRNPU	3192	broad.mit.edu	37	1	245027113	245027113	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:245027113G>T	ENST00000444376.2	-	1	731	c.497C>A	c.(496-498)cCg>cAg	p.P166Q	HNRNPU_ENST00000283179.9_Missense_Mutation_p.P166Q	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	166	Gln-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CTGCGTCGCCGGCGGTTGAGG	0.711000													4	17					0.00909568	0.00920751	1	1	0
SETDB2	83852	broad.mit.edu	37	13	50065014	50065014	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr13:50065014G>A	ENST00000354234.4	+	13	2880	c.1974G>A	c.(1972-1974)agG>agA	p.R658R	SETDB2_ENST00000317257.8_Silent_p.R670R	NM_001160308.1	NP_001153780.1	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2	670	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	15		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		CACACAACAGGAATTTTCCAT	0.323000													15	24					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148947825	148947825	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:148947825G>A	ENST00000335870.2	+	3	596	c.468G>A	c.(466-468)gaG>gaA	p.E156E		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	156	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			AGGAATGGGAGAATCTGGAGG	0.488000													20	75					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4304782	4304782	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:4304782G>C	ENST00000404826.2	+	45	6547	c.6408G>C	c.(6406-6408)gcG>gcC	p.A2136A	SDK1_ENST00000466611.1_3'UTR|SDK1_ENST00000389531.3_Silent_p.A2116A	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2136					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACGAGGACGCGCTGCCCAAGC	0.682000													6	38					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70460923	70460923	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:70460923T>C	ENST00000373998.1	-	25	4617	c.3920A>G	c.(3919-3921)tAc>tGc	p.Y1307C	ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000353904.2_Missense_Mutation_p.Y1319C|ZMYM3_ENST00000314425.5_Missense_Mutation_p.Y1319C|ZMYM3_ENST00000373988.1_Missense_Mutation_p.Y1321C|ZMYM3_ENST00000373984.3_Missense_Mutation_p.Y1229C	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1319					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					AGGTTGCAGGTAGAACACATC	0.572000													6	18					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170024529	170024529	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:170024529G>C	ENST00000361580.2	-	2	308	c.81C>G	c.(79-81)ctC>ctG	p.L27L	KIFAP3_ENST00000367765.1_5'UTR|KIFAP3_ENST00000490550.1_5'UTR|KIFAP3_ENST00000367767.1_Intron|KIFAP3_ENST00000538366.1_5'UTR	NM_014970.3	NP_055785.2	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	27					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTGAACAATGAGTGCTTTTT	0.348000													7	34					0	0	1	0	0
MOB1A	55233	broad.mit.edu	37	2	74386310	74386310	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:74386310G>A	ENST00000396049.3	-	5	674	c.481C>T	c.(481-483)Cat>Tat	p.H161Y	MOB1A_ENST00000497054.1_5'UTR	NM_018221.3	NP_060691.2	Q9H8S9	MOL1B_HUMAN	MOB kinase activator 1A	161					hippo signaling cascade		metal ion binding|protein binding										TGATAAATATGGGCATAAACC	0.398000													12	62					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39090740	39090740	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:39090740C>T	ENST00000591517.1	-	21	1613	c.1585G>A	c.(1585-1587)Gac>Aac	p.D529N	MAP4K1_ENST00000589130.1_Missense_Mutation_p.D525N|MAP4K1_ENST00000396857.2_Missense_Mutation_p.D529N|MAP4K1_ENST00000586296.1_Intron|CTB-186G2.1_ENST00000589557.1_RNA|MAP4K1_ENST00000423454.2_Missense_Mutation_p.D191N	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	529	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCCTCCTGGTCATTCCGGTTC	0.627000													10	54					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18301781	18301781	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr22:18301781G>C	ENST00000441493.2	-	26	3998	c.3646C>G	c.(3646-3648)Ctg>Gtg	p.L1216V		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1216	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ACAGCTTTCAGATCCGAGGGG	0.622000													7	34					0	0	1	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794486	18794486	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:18794486C>G	ENST00000377428.2	+	1	117	c.27C>G	c.(25-27)ccC>ccG	p.P9P	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		ACCATCAACCCAAGATCAAAG	0.517000													5	44					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107782176	107782176	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:107782176C>T	ENST00000311955.3	-	1	297	c.243G>A	c.(241-243)tcG>tcA	p.S81S		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	81					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding	p.S81S(1)		breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GGCGGGGTGGCGACTTTGGGG	0.552000													15	88					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95792158	95792158	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:95792158C>G	ENST00000375482.3	+	15	2056	c.1560C>G	c.(1558-1560)ctC>ctG	p.L520L	FGD3_ENST00000416701.2_Silent_p.L520L|FGD3_ENST00000538555.1_Silent_p.L123L|FGD3_ENST00000337352.6_Silent_p.L520L	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	520					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						CCTTATAGCTCGAGCCCAGAA	0.517000													5	62					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100173388	100173388	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:100173388G>C	ENST00000310300.6	-	17	1846	c.1794C>G	c.(1792-1794)ctC>ctG	p.L598L	LRCH4_ENST00000497245.1_Silent_p.L146L	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	598	CH.				nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCCGAGCCTTGAGGGCACTGA	0.577000													30	221					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167653184	167653184	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:167653184G>C	ENST00000519204.1	+	23	4955	c.4837G>C	c.(4837-4839)Gac>Cac	p.D1613H	TENM2_ENST00000520394.1_Missense_Mutation_p.D1495H|TENM2_ENST00000518659.1_Missense_Mutation_p.D1734H|TENM2_ENST00000403607.2_Missense_Mutation_p.D1558H|TENM2_ENST00000545108.1_Missense_Mutation_p.D1733H					teneurin transmembrane protein 2																		TATTACCATTGACATTGAGAA	0.552000													3	24					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15517023	15517023	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:15517023G>A	ENST00000344577.2	-	9	1304	c.1279C>T	c.(1279-1281)Cag>Tag	p.Q427*	LIPI_ENST00000536861.1_Nonsense_Mutation_p.Q406*	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	406					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTGAGCTCTGGAAATATGTC	0.308000													9	80					0	0	1	0	0
EIF2B5	8893	broad.mit.edu	37	3	183861984	183861984	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:183861984A>C	ENST00000273783.3	+	14	2089	c.1967A>C	c.(1966-1968)cAt>cCt	p.H656P	EIF2B5_ENST00000444495.1_Missense_Mutation_p.H656P	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	656	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TTCCTAGAGCATGAAGCTCTT	0.502000													70	200					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70952388	70952388	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:70952388A>T	ENST00000357250.6	-	29	2061	c.1903T>A	c.(1903-1905)Tcc>Acc	p.S635T	COL9A1_ENST00000320755.7_Missense_Mutation_p.S392T|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Missense_Mutation_p.S392T	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	635	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGGCCTGGGGATCCCACTGGT	0.353000													7	49					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242253286	242253286	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:242253286C>T	ENST00000442594.2	-	11	1714	c.1205G>A	c.(1204-1206)tGg>tAg	p.W402*	PLD5_ENST00000427495.1_Nonsense_Mutation_p.W432*|PLD5_ENST00000536534.1_Nonsense_Mutation_p.W494*	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	494						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CGGTGAATACCAGTCCCTTTC	0.468000													27	198					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95535261	95535261	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:95535261C>A	ENST00000343958.4	-	6	2963	c.2740G>T	c.(2740-2742)Gag>Tag	p.E914*	FGD6_ENST00000549499.1_Nonsense_Mutation_p.E914*|FGD6_ENST00000546711.1_Nonsense_Mutation_p.E914*	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	914	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.E914Q(1)		breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATCCGGTCCTCAATCACTGGT	0.453000													6	69					0.0215528	0.0217287	1	1	0
SAPCD1	401251	broad.mit.edu	37	6	31732230	31732230	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:31732230G>A	ENST00000415669.2	+	5	518	c.459G>A	c.(457-459)caG>caA	p.Q153Q	SAPCD1-AS1_ENST00000419679.1_RNA|SAPCD1_ENST00000425424.1_Silent_p.Q123Q|MSH5_ENST00000534153.4_3'UTR|MSH5-SAPCD1_ENST00000493662.2_3'UTR	NM_001039651.1	NP_001034740.1	Q5SSQ6	G7D_HUMAN	suppressor APC domain containing 1	123																	CAAGGCAGCAGAAAGGAGTCA	0.607000													14	46					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261774	32261774	+	Nonsense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:32261774T>A	ENST00000375015.4	-	26	873	c.673A>T	c.(673-675)Aaa>Taa	p.K225*	C6orf10_ENST00000375007.4_Nonsense_Mutation_p.K224*|C6orf10_ENST00000442822.2_Nonsense_Mutation_p.K217*|C6orf10_ENST00000533191.1_Nonsense_Mutation_p.K224*|C6orf10_ENST00000447241.2_Nonsense_Mutation_p.K226*|C6orf10_ENST00000527965.1_Nonsense_Mutation_p.K210*			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	226						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						GAACAAGATTTTTTTGCAAGT	0.333000													22	110					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240524	126240524	+	Silent	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:126240524C>A	ENST00000394329.3	+	1	2971	c.2958C>A	c.(2956-2958)gtC>gtA	p.V986V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	986	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGTTTATGTCCATGATGTAA	0.438000													13	94					9.31168e-06	9.829e-06	1	1	0
HLA-A	3105	broad.mit.edu	37	6	29910797	29910797	+	Nonsense_Mutation	SNP	G	G	T	rs41559912		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr6:29910797G>T	ENST00000396634.1	+	4	678	c.337G>T	c.(337-339)Gag>Tag	p.E113*	HLA-A_ENST00000376806.5_Nonsense_Mutation_p.E113*|HLA-A_ENST00000376809.5_Nonsense_Mutation_p.E113*|HLA-A_ENST00000376802.2_Nonsense_Mutation_p.E113*			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	113	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						CAACCAGAGCGAGGCCGGTGA	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			10	15					1.33834e-09	1.45947e-09	1	1	0
FERMT3	83706	broad.mit.edu	37	11	63978126	63978126	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:63978126G>A	ENST00000279227.5	+	3	299	c.204G>A	c.(202-204)caG>caA	p.Q68Q	FERMT3_ENST00000345728.5_Silent_p.Q68Q	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	68					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						GGTGGGAACAGAAGAGGCAGT	0.632000													42	152					0	0	1	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498195	73498195	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:73498195G>C	ENST00000321617.3	-	18	3546	c.2960C>G	c.(2959-2961)tCa>tGa	p.S987*	CASKIN2_ENST00000433559.2_Nonsense_Mutation_p.S905*	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	987	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			AACAGTGTCTGATTCCGTGAG	0.677000													6	29					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111745538	111745538	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr9:111745538C>G	ENST00000374595.4	-	6	866	c.787G>C	c.(787-789)Gac>Cac	p.D263H	CTNNAL1_ENST00000325551.4_Missense_Mutation_p.D263H|CTNNAL1_ENST00000325580.6_Missense_Mutation_p.D263H			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	263					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		TTCATACGGTCAAATACTCCT	0.333000													14	60					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130963477	130963477	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:130963477C>T	ENST00000261655.4	-	3	245	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	RIMBP2_ENST00000535703.1_5'UTR|RIMBP2_ENST00000536002.1_5'UTR	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	28						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		AGGTCAATTTCCTGCTGCTTG	0.667000													7	44					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3702326	3702326	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:3702326C>T	ENST00000382622.3	+	10	1553	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	PRMT8_ENST00000452611.2_Missense_Mutation_p.S379F|PRMT8_ENST00000261252.4_3'UTR	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	388					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			ACATCTGTATCTAATGACTAC	0.512000													4	29					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156276899	156276899	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:156276899C>G	ENST00000311277.4	-	9	1522	c.1259G>C	c.(1258-1260)aGa>aCa	p.R420T	AC097467.2_ENST00000417474.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.R396T|AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000593387.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	420					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		GTTATCTGCTCTATCAGGTTC	0.353000													6	25					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3139829	3139829	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:3139829G>A	ENST00000446632.2	-	6	1087	c.513C>T	c.(511-513)ctC>ctT	p.L171L	IL5RA_ENST00000256452.3_Silent_p.L171L|IL5RA_ENST00000456302.1_Silent_p.L171L|IL5RA_ENST00000383846.1_Silent_p.L171L|IL5RA_ENST00000438560.1_Silent_p.L171L|IL5RA_ENST00000445864.2_Intron|IL5RA_ENST00000430514.2_Silent_p.L171L|IL5RA_ENST00000311981.8_Silent_p.L171L|IL5RA_ENST00000418488.2_Silent_p.L171L	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	171					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		ACCTATAGTAGAGAAAATACT	0.418000													13	50					0	0	1	0	0
TMEM45A	55076	broad.mit.edu	37	3	100275640	100275640	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:100275640A>T	ENST00000403410.1	+	5	895	c.275A>T	c.(274-276)cAt>cTt	p.H92L	TMEM45A_ENST00000323523.4_Missense_Mutation_p.H76L|TMEM45A_ENST00000462884.1_3'UTR			Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	76						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)	11						GGAGGGCCCCATCTGATGTTA	0.448000													6	20					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	153994063	153994063	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:153994063C>T	ENST00000496811.1	-	25	3004	c.2924G>A	c.(2923-2925)aGa>aAa	p.R975K	DHX36_ENST00000544526.1_Missense_Mutation_p.R961K|DHX36_ENST00000308361.6_Missense_Mutation_p.R946K|DHX36_ENST00000329463.5_Missense_Mutation_p.R961K	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	975						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGCACAGTCTCTGGATTTAGT	0.403000													10	116					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6619268	6619268	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:6619268C>G	ENST00000315579.5	+	4	1030	c.231C>G	c.(229-231)ctC>ctG	p.L77L	NCAPD2_ENST00000545962.1_Intron	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	77	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						ATCCTGGCCTCAAAGAAGATA	0.448000													9	68					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48343025	48343025	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:48343025T>G	ENST00000221996.7	+	4	907	c.701T>G	c.(700-702)cTt>cGt	p.L234R	CRX_ENST00000539067.1_Missense_Mutation_p.L234R|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	234					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GGCCCGGCTCTTAGCCCCCTC	0.652000													7	159					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40337915	40337915	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:40337915C>G	ENST00000310169.2	+	2	275	c.136C>G	c.(136-138)Ctt>Gtt	p.L46V		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	46					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TTCTAATGCTCTTCGTCCAGT	0.418000													19	84					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59926549	59926549	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:59926549C>T	ENST00000259008.2	-	5	715	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	BRIP1_ENST00000577598.1_Missense_Mutation_p.E150K	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	150	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						TCATCATTTTCATCTCTGTAT	0.343000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					16	75					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:140237249G>C	ENST00000307360.5	+	1	1616	c.1616G>C	c.(1615-1617)gGg>gCg	p.G539A	PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.G539A(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687000													5	171					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62652990	62652990	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:62652990C>T	ENST00000377892.1	+	11	1673	c.1449C>T	c.(1447-1449)ctC>ctT	p.L483L	SLC3A2_ENST00000377891.2_Silent_p.L453L|SLC3A2_ENST00000538682.1_3'UTR|SLC3A2_ENST00000536981.1_5'UTR|SLC3A2_ENST00000377890.2_Silent_p.L452L|SLC3A2_ENST00000535296.1_Silent_p.L421L|SLC3A2_ENST00000338663.7_Silent_p.L351L|SLC3A2_ENST00000377889.2_Silent_p.L390L			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	452					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						TTCTCCGACTCTACCAGCTGA	0.577000													12	240					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1443220	1443220	+	Silent	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:1443220G>C	ENST00000270349.9	-	2	220	c.93C>G	c.(91-93)ctC>ctG	p.L31L	SLC6A3_ENST00000453492.2_Silent_p.L31L	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	31					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TGACAAGGATGAGCTCCACCT	0.642000													16	59					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64408433	64408433	+	Silent	SNP	A	A	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:64408433A>C	ENST00000358025.3	+	4	392	c.162A>C	c.(160-162)atA>atC	p.I54I	SYNE2_ENST00000341472.5_Silent_p.I54I|SYNE2_ENST00000356081.3_Silent_p.I54I|SYNE2_ENST00000344113.4_Silent_p.I54I|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Silent_p.I54I	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	54	Actin-binding.|CH 1.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCTCAGTTATATCCGACCTAT	0.378000													9	62					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159847213	159847213	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:159847213G>A	ENST00000426543.2	-	9	1284	c.829C>T	c.(829-831)Cgg>Tgg	p.R277W	CCDC19_ENST00000368099.4_Missense_Mutation_p.R362W|CCDC19_ENST00000476696.1_5'UTR			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	362						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TTCTCCCTCCGGATTCTCTCC	0.552000													51	125					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123518199	123518199	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chrX:123518199C>G	ENST00000422452.2	-	30	6645	c.6582G>C	c.(6580-6582)aaG>aaC	p.K2194N	TENM1_ENST00000371130.3_Missense_Mutation_p.K2187N|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GACGAGCACTCTTCCCATGGC	0.443000													4	72					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177913762	177913762	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:177913762C>G	ENST00000308284.6	-	15	1904	c.1815G>C	c.(1813-1815)caG>caC	p.Q605H	RP4-798P15.3_ENST00000354921.2_5'UTR|RP4-798P15.3_ENST00000528461.1_3'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	605					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						TTTCCGTCCTCTGGATTGCCT	0.473000													19	110					0	0	1	0	0
ACP2	53	broad.mit.edu	37	11	47261760	47261760	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:47261760G>A	ENST00000256997.3	-	11	1295	c.1179C>T	c.(1177-1179)ttC>ttT	p.F393F	ACP2_ENST00000527256.1_Silent_p.F361F|ACP2_ENST00000525230.1_5'UTR|ACP2_ENST00000537863.1_Silent_p.F206F|ACP2_ENST00000533929.1_Silent_p.F365F|ACP2_ENST00000529444.1_Silent_p.F330F	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	393						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						CTATGAGGAGGAAGAGGATGG	0.597000													6	38					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75676154	75676154	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:75676154C>T	ENST00000446342.1	+	10	1558	c.1076C>T	c.(1075-1077)tCa>tTa	p.S359L	C10orf55_ENST00000412307.2_Intron|PLAU_ENST00000372764.3_Missense_Mutation_p.S376L|C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000372762.4_Missense_Mutation_p.S340L	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	376	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	CAGGGAGACTCAGGGGGACCC	0.557000													6	10					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232843	71232843	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:71232843G>A	ENST00000359042.2	+	3	1416	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000426147.2_Missense_Mutation_p.E408K|C17orf80_ENST00000535032.2_Missense_Mutation_p.E408K|C17orf80_ENST00000268942.8_Missense_Mutation_p.E408K|C17orf80_ENST00000577615.1_Missense_Mutation_p.E408K|C17orf80_ENST00000255557.4_Missense_Mutation_p.E408K|FAM104A_ENST00000583178.1_5'UTR	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	408						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			GGAGAGTCCCGAGGGACAGTT	0.473000													12	54					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61190019	61190019	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:61190019C>G	ENST00000216513.4	-	1	833	c.774G>C	c.(772-774)aaG>aaC	p.K258N		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	258						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GGCCGGTGATCTTGGCCAGGT	0.607000													5	27					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26514792	26514792	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:26514792G>A	ENST00000531191.1	+	16	1755	c.748G>A	c.(748-750)Gag>Aag	p.E250K	CNKSR1_ENST00000374253.5_Missense_Mutation_p.E515K|CNKSR1_ENST00000361530.6_Missense_Mutation_p.E508K			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	515	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CCCACCCCGAGAGGAAGGTAG	0.602000													7	43					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886995	123886995	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:123886995G>A	ENST00000320891.4	+	1	714	c.714G>A	c.(712-714)caG>caA	p.Q238Q		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGCCTTTCAGACCTGTGCCT	0.542000													7	55					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27001327	27001327	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:27001327G>C	ENST00000314616.6	+	3	419	c.136G>C	c.(136-138)Gat>Cat	p.D46H	SUPT6H_ENST00000347486.4_Missense_Mutation_p.D46H	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	46	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GGAGAACCTAGATGATCAGGA	0.468000													7	36					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195799003	195799003	+	Translation_Start_Site	SNP	T	T	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:195799003T>C	ENST00000535031.1	-	0	128				TFRC_ENST00000420415.1_Missense_Mutation_p.Y71C|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000360110.4_Missense_Mutation_p.Y152C|TFRC_ENST00000392396.3_Missense_Mutation_p.Y152C			P02786	TFR1_HUMAN	transferrin receptor						cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		ACGAGGGACATATGAATTTTC	0.328000			T	BCL6	NHL								11	84					0	0	1	0	0
TPH1	7166	broad.mit.edu	37	11	18045526	18045526	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:18045526T>A	ENST00000250018.2	-	8	1497	c.935A>T	c.(934-936)tAc>tTc	p.Y312F	TPH1_ENST00000341556.2_Missense_Mutation_p.Y312F	NM_004179.2	NP_004170.1	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	312					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(14)|prostate(1)|stomach(1)	25					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	AGTGAAAAAGTAGCACTGCAA	0.353000													8	68					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26096140	26096140	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:26096140G>A	ENST00000313735.6	-	17	2130	c.1897C>T	c.(1897-1899)Cgg>Tgg	p.R633W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	633	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCGCAGAACCGAGGGTACATG	0.607000													10	17					0	0	1	0	0
FAM115A	9747	broad.mit.edu	37	7	143573255	143573255	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:143573255G>A	ENST00000479870.1	-	2	655	c.447C>T	c.(445-447)ctC>ctT	p.L149L	FAM115A_ENST00000355951.2_Silent_p.L149L|FAM115A_ENST00000392900.3_Intron	NM_001206938.1|NM_001206941.1|NM_014719.2	NP_001193867.1|NP_001193870.1|NP_055534.1	Q9Y4C2	F115A_HUMAN	family with sequence similarity 115, member A	149										NS(1)|endometrium(1)|lung(5)	7	Melanoma(164;0.0903)					GTCCTCCTATGAGCAAGCCGC	0.512000													22	33					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296674	39296674	+	Silent	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:39296674G>A	ENST00000345847.4	-	1	65	c.66C>T	c.(64-66)cgC>cgT	p.R22R		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	22	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						AGCAGCTGGGGCGGCAGCAGG	0.632000													5	95					0	0	1	0	0
MIR124-2HG	100130155	broad.mit.edu	37	8	65291894	65291894	+	RNA	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:65291894C>T	ENST00000521441.1	+	0	655																											GAACCCATCTCTTGCCGCATA	0.517000													4	18					0	0	1	0	0
SKIL	6498	broad.mit.edu	37	3	170078459	170078459	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:170078459G>C	ENST00000458537.3	+	1	1049	c.340G>C	c.(340-342)Gaa>Caa	p.E114Q	SKIL_ENST00000426052.2_Missense_Mutation_p.E94Q|SKIL_ENST00000413427.2_Missense_Mutation_p.E114Q|SKIL_ENST00000259119.4_Missense_Mutation_p.E114Q	NM_001145097.2|NM_001248008.1|NM_005414.4	NP_001138569.1|NP_001234937.1|NP_005405.2	P12757	SKIL_HUMAN	SKI-like oncogene	114					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	25	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GCATTCCCAAGAAAGCATGTC	0.483000													4	259					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31294357	31294357	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:31294357G>A	ENST00000265071.2	+	3	782	c.517G>A	c.(517-519)Gat>Aat	p.D173N	CDH6_ENST00000514738.1_Missense_Mutation_p.D118N	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	173	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TGAAATGTCTGATGTCGGTGA	0.473000													23	160					0	0	1	0	0
CDCA7L	55536	broad.mit.edu	37	7	21956485	21956485	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr7:21956485T>G	ENST00000406877.3	-	2	331	c.52A>C	c.(52-54)Aac>Cac	p.N18H	CDCA7L_ENST00000373934.4_Missense_Mutation_p.N18H|CDCA7L_ENST00000356195.5_5'UTR|CDCA7L_ENST00000465490.1_5'UTR	NM_018719.4	NP_061189.2	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like	18					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	29						CTGGGGGCGTTAAAGATGTCA	0.463000													16	135					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124268174	124268174	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr8:124268174G>A	ENST00000395571.3	-	3	630	c.13C>T	c.(13-15)Cga>Tga	p.R5*	ZHX1_ENST00000522655.1_Nonsense_Mutation_p.R5*|ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000522595.1_5'UTR|ZHX1_ENST00000297857.2_Nonsense_Mutation_p.R5*	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	5					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GTTGATTTTCGCCTGCTTGCC	0.423000													17	140					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29221896	29221896	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:29221896G>C	ENST00000321990.4	+	23	5878	c.5500G>C	c.(5500-5502)Gag>Cag	p.E1834Q		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1834					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CATTCCAAAAGAGACTGTGAA	0.284000													9	43					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52537040	52537040	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:52537040C>G	ENST00000594154.1	-	5	2104	c.1892G>C	c.(1891-1893)aGa>aCa	p.R631T	ZNF432_ENST00000221315.5_Missense_Mutation_p.R631T			O94892	ZN432_HUMAN	zinc finger protein 432	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GAAGGCTTTTCTACATTCACT	0.413000													26	104					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198274541	198274541	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:198274541G>C	ENST00000335508.5	-	7	948	c.857C>G	c.(856-858)tCc>tGc	p.S286C		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	286	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ACGAGCACTGGAAGTTGCGCC	0.517000			Mis		myelodysplastic syndrome								43	261					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33532820	33532820	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:33532820C>T	ENST00000228567.3	-	6	1743	c.1447G>A	c.(1447-1449)Gaa>Aaa	p.E483K	SYT10_ENST00000535526.1_Missense_Mutation_p.E302K	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	483						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GCCAGCATTTCATTCCAGTGG	0.463000													10	78					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5768242	5768242	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:5768242C>A	ENST00000381624.3	+	18	1684	c.1623C>A	c.(1621-1623)ttC>ttA	p.F541L	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Missense_Mutation_p.F199L	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	541						integral to membrane											ATTACAGCTTCATCATCGAGA	0.498000													17	87					2.35188e-11	2.58759e-11	1	1	0
TNIP3	79931	broad.mit.edu	37	4	122079850	122079850	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr4:122079850C>T	ENST00000454328.1	-	5	432	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	TNIP3_ENST00000507879.1_Missense_Mutation_p.E139K|TNIP3_ENST00000057513.3_Missense_Mutation_p.E69K|TNIP3_ENST00000509841.1_Missense_Mutation_p.E146K			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	69										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						ACCTTTCTTTCATATAACTCT	0.363000													12	47					0	0	1	0	0
DHRS12	79758	broad.mit.edu	37	13	52343425	52343425	+	Silent	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr13:52343425C>T	ENST00000218981.1	-	8	675	c.564G>A	c.(562-564)gtG>gtA	p.V188V	DHRS12_ENST00000444610.2_Silent_p.V237V	NM_024705.2	NP_078981.1	A0PJE2	DHR12_HUMAN	dehydrogenase/reductase (SDR family) member 12	237							binding|oxidoreductase activity			cervix(1)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	7		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		TCGCCTGCCTCACACCTGGGA	0.572000													4	6					0	0	1	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121116732	121116732	+	RNA	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:121116732C>T	ENST00000437515.1	-	0	329																											CATCAAAGCCCAGAATGAGTA	0.428000													4	36					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197423875	197423875	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:197423875G>C	ENST00000273582.5	-	9	1717	c.1172C>G	c.(1171-1173)tCt>tGt	p.S391C	KIAA0226_ENST00000296343.5_Missense_Mutation_p.S436C|KIAA0226_ENST00000389665.5_Missense_Mutation_p.S436C	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	436	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GCTTTGACCAGAGTAGGGCAA	0.463000													7	78					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15937124	15937124	+	Silent	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:15937124C>G	ENST00000504595.1	+	4	1786	c.1305C>G	c.(1303-1305)ctC>ctG	p.L435L	FBXL7_ENST00000510662.1_Silent_p.L388L|FBXL7_ENST00000329673.7_Silent_p.L423L	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	435					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GGCTCAGCCTCAAGTCCTGCG	0.597000													5	53					0	0	1	0	0
IFIH1	64135	broad.mit.edu	37	2	163134157	163134157	+	Missense_Mutation	SNP	C	C	G	rs118172671	by1000genomes	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:163134157C>G	ENST00000263642.2	-	10	2207	c.1812G>C	c.(1810-1812)ttG>ttC	p.L604F		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	604					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						TGTACTTCCTCAAATGTTCTG	0.323000													12	74					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104046477	104046477	+	Silent	SNP	C	C	T	rs73187902	byFrequency	TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:104046477C>T	ENST00000388887.2	+	12	1605	c.1401C>T	c.(1399-1401)agC>agT	p.S467S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	467	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TCTTCAACAGCGATAAGGTAA	0.408000													15	72					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39798699	39798699	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:39798699G>A	ENST00000564288.1	+	37	7216	c.6439G>A	c.(6439-6441)Gac>Aac	p.D2147N	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.D2184N|MACF1_ENST00000289893.4_Missense_Mutation_p.D587N|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.D2152N			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2152					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTGGTGGTTGACAAAGATGT	0.463000													4	34					0	0	1	0	0
TM9SF3	56889	broad.mit.edu	37	10	98287224	98287224	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:98287224G>C	ENST00000371142.4	-	13	1787	c.1571C>G	c.(1570-1572)tCa>tGa	p.S524*		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	524						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		GATTGCAGTTGATGCAGCAGA	0.333000													5	35					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48523152	48523152	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr13:48523152C>T	ENST00000378654.3	-	10	1296	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N	SUCLA2_ENST00000543413.1_Missense_Mutation_p.D356N|SUCLA2_ENST00000544100.1_Missense_Mutation_p.D280N|SUCLA2_ENST00000534875.1_Missense_Mutation_p.D356N	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	414					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	TTAGCATCATCGACTCGTGTA	0.338000													35	65					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12186572	12186572	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr19:12186572C>A	ENST00000439326.3	+	4	812	c.637C>A	c.(637-639)Ctt>Att	p.L213I	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						CAGCATATATCTTATACATGA	0.358000													13	25					0.00185496	0.00190114	1	1	0
MAL	4118	broad.mit.edu	37	2	95715329	95715329	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr2:95715329G>A	ENST00000309988.4	+	3	374	c.265G>A	c.(265-267)Gca>Aca	p.A89T	MAL_ENST00000349807.3_Intron|MAL_ENST00000354078.3_Missense_Mutation_p.A33T|MAL_ENST00000353004.3_Intron	NM_002371.3	NP_002362.1	P21145	MAL_HUMAN	mal, T-cell differentiation protein	89	MARVEL.				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(2)	10				STAD - Stomach adenocarcinoma(1183;0.18)		CCCATAGGACGCAGCCTACCA	0.652000													11	104					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106235831	106235831	+	RNA	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr14:106235831C>G	ENST00000390551.2	-	0	875																											GTCAGGCTGACCTGGTTCTTG	0.632000													33	181					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16337215	16337215	+	Nonsense_Mutation	SNP	G	G	C	rs143987252		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr21:16337215G>C	ENST00000400202.1	-	3	4011	c.3299C>G	c.(3298-3300)tCa>tGa	p.S1100*	NRIP1_ENST00000318948.4_Nonsense_Mutation_p.S1100*|NRIP1_ENST00000400199.1_Nonsense_Mutation_p.S1100*			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	1100					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TGTGACCTGTGAGACACTTTC	0.398000													31	142					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43938283	43938283	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr20:43938283C>T	ENST00000343694.3	+	3	280	c.208C>T	c.(208-210)Cgg>Tgg	p.R70W	RBPJL_ENST00000372743.1_Missense_Mutation_p.R70W|RBPJL_ENST00000372741.3_Missense_Mutation_p.R70W	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	70					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				ACAGACTGTGCGGATCCTGCA	0.607000													22	28					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838397	16838397	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr11:16838397C>G	ENST00000355661.3	-	11	1826	c.1816G>C	c.(1816-1818)Gac>Cac	p.D606H	PLEKHA7_ENST00000531066.1_Missense_Mutation_p.D606H|PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.D606H			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	606	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						AGCGAGATGTCCACACTCCTC	0.662000													5	72					0	0	1	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75785095	75785095	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr12:75785095G>A	ENST00000550916.1	+	1	246	c.199G>A	c.(199-201)Gac>Aac	p.D67N	GLIPR1L2_ENST00000378689.2_Missense_Mutation_p.D67N|GLIPR1L2_ENST00000320460.4_Missense_Mutation_p.D67N|GLIPR1L2_ENST00000378692.3_5'UTR|GLIPR1L2_ENST00000435775.1_Missense_Mutation_p.D67N|GLIPR1L2_ENST00000547164.1_Missense_Mutation_p.D67N	NM_001270396.1	NP_001257325.1	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	67						integral to membrane				kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16						GCTGCGGGGCGACGTCATTCC	0.562000											OREG0021999	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	92					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39838149	39838150	+	Splice_Site	DEL	AG	AG	-			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:39838149_39838150delAG	ENST00000564288.1	+	52	13872		c.e52-1		MACF1_ENST00000539005.1_Splice_Site|MACF1_ENST00000476350.1_Splice_Site|MACF1_ENST00000361689.2_Splice_Site|MACF1_ENST00000289893.4_Splice_Site|MACF1_ENST00000567887.1_Splice_Site|MACF1_ENST00000372915.3_Splice_Site|MACF1_ENST00000317713.7_Splice_Site|MACF1_ENST00000545844.1_Splice_Site			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTCTTTAAACAGAGTCTACTAG	0.386													8	63	---	---	---	---					
LRP8	7804	broad.mit.edu	37	1	53793508	53793509	+	In_Frame_Ins	INS	-	-	GCC			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr1:53793508_53793509insGCC	ENST00000306052.6	-	1	177_178	c.76_77insGGC	c.(76-78)cca>GGCcca	p.25_26insG	LRP8_ENST00000371454.2_In_Frame_Ins_p.25_26insG|LRP8_ENST00000354412.3_In_Frame_Ins_p.25_26insG|LRP8_ENST00000347547.2_In_Frame_Ins_p.25_26insG	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	25			Q -> R (in dbSNP:rs4926972).		cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						AAGATGCTGGagctgcagcagc	0.728													2	4	---	---	---	---					
SACM1L	22908	broad.mit.edu	37	3	45785086	45785087	+	Frame_Shift_Ins	INS	-	-	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:45785086_45785087insT	ENST00000389061.5	+	20	1893_1894	c.1689_1690insT	c.(1687-1692)acttttfs	p.TF563fs	SACM1L_ENST00000541314.1_Frame_Shift_Ins_p.TF502fs|SACM1L_ENST00000418611.1_Frame_Shift_Ins_p.TF460fs	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	563						Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GCATTGGAACATTTTTTATCAT	0.391													28	114	---	---	---	---					
ADIPOQ	9370	broad.mit.edu	37	3	186572338	186572339	+	Frame_Shift_Ins	INS	-	-	T			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:186572338_186572339insT	ENST00000412955.2	+	3	721_722	c.580_581insT	c.(580-582)ggafs	p.G194fs	ADIPOQ_ENST00000444204.2_Frame_Shift_Ins_p.G194fs|ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000320741.2_Frame_Shift_Ins_p.G194fs			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	194	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGAAAATAATGTGGACCAGGCC	0.515													19	108	---	---	---	---					
TP63	8626	broad.mit.edu	37	3	189582134	189582135	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr3:189582134_189582135insA	ENST00000264731.3	+	5	782_783	c.693_694insA	c.(691-696)taaaaafs	p.*K231fs	TP63_ENST00000320472.5_Frame_Shift_Ins_p.*K231fs|TP63_ENST00000449992.1_Frame_Shift_Ins_p.*K52fs|TP63_ENST00000440651.2_Frame_Shift_Ins_p.*K231fs|TP63_ENST00000437221.1_Frame_Shift_Ins_p.*K137fs|TP63_ENST00000354600.5_Frame_Shift_Ins_p.*K137fs|TP63_ENST00000418709.2_Frame_Shift_Ins_p.*K231fs|TP63_ENST00000382063.4_Frame_Shift_Ins_p.*K146fs|TP63_ENST00000456148.1_Frame_Shift_Ins_p.*K137fs|TP63_ENST00000392460.3_Frame_Shift_Ins_p.*K231fs|TP63_ENST00000392461.3_Frame_Shift_Ins_p.*K137fs|TP63_ENST00000392463.2_Frame_Shift_Ins_p.*K137fs	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	231					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGCCTGTCTACAAAAAAGCTGA	0.510										HNSCC(45;0.13)			11	143	---	---	---	---					
CTD-2296D1.4	0	broad.mit.edu	37	5	7372660	7372662	+	RNA	DEL	CAT	CAT	-			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:7372660_7372662delCAT	ENST00000513219.1	-	0	202																											ccaccaccaccatcaccaccacc	0.601													3	4	---	---	---	---					
SLC22A5	6584	broad.mit.edu	37	5	131726594	131726595	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr5:131726594_131726595insA	ENST00000245407.3	+	7	1486_1487	c.1265_1266insA	c.(1264-1266)cgafs	p.R422fs	SLC22A5_ENST00000435065.2_Frame_Shift_Ins_p.R446fs|SLC22A5_ENST00000479605.1_3'UTR	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	422					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CTGGTACCCCCAGGTAGGGACC	0.515													9	45	---	---	---	---					
PITRM1	10531	broad.mit.edu	37	10	3206071	3206074	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr10:3206071_3206074delTGTC	ENST00000380989.2	-	7	672_675	c.634_637delGACA	c.(634-639)atfs	p.DN212fs	PITRM1_ENST00000224949.4_Frame_Shift_Del_p.DN212fs|PITRM1_ENST00000451104.2_Frame_Shift_Del_p.DN180fs|PITRM1-AS1_ENST00000598280.1_RNA|PITRM1-AS1_ENST00000601046.1_RNA	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	180					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						ATCCTCTCATTGTCTGTCTTGAAA	0.412													10	50	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													6	8	---	---	---	---					
ZNF750	79755	broad.mit.edu	37	17	80790224	80790225	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-T3-A92M-01A-31D-A391-08	TCGA-T3-A92M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e91f3779-4ab6-425f-b667-19fbda3f8cca	698fe76b-d251-4cd4-aced-378aeee4c037	g.chr17:80790224_80790225insCA	ENST00000269394.3	-	2	939_940	c.106_107insTG	c.(106-108)gaafs	p.E36fs	TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000539345.2_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	36						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ATGTGACTTCTCATTGCAAGTA	0.411													35	59	---	---	---	---