Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IFT172	26160	broad.mit.edu	37	2	27680574	27680574	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:27680574C>T	ENST00000260570.3	-	29	3263	c.3160G>A	c.(3160-3162)Gag>Aag	p.E1054K		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1054					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCCTGGGCCTCGAGGTAGTGG	0.582000													21	30					0	0	1	0	0
SCAMP5	192683	broad.mit.edu	37	15	75305126	75305126	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:75305126G>A	ENST00000361900.6	+	4	323	c.116G>A	c.(115-117)cGc>cAc	p.R39H	SCAMP5_ENST00000562212.1_Missense_Mutation_p.R39H|SCAMP5_ENST00000545456.1_Silent_p.A20A|SCAMP5_ENST00000425597.3_Missense_Mutation_p.R39H|SCAMP5_ENST00000565923.1_3'UTR	NM_001178111.1	NP_001171582.1	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	39					exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	5						ATGACCAAGCGCCTCTACTAC	0.587000													16	27					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96091364	96091364	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr4:96091364A>T	ENST00000453304.1	-	15	2919	c.2571T>A	c.(2569-2571)gaT>gaA	p.D857E		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	857	Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCTGGGGGGCATCCAGGCTGC	0.597000													83	139					0	0	1	0	0
ARHGDIA	396	broad.mit.edu	37	17	79826815	79826815	+	Missense_Mutation	SNP	G	G	C	rs115573742	byFrequency	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr17:79826815G>C	ENST00000269321.7	-	6	687	c.552C>G	c.(550-552)gaC>gaG	p.D184E	ARHGDIA_ENST00000580685.1_Missense_Mutation_p.D184E|ARHGDIA_ENST00000400721.4_Missense_Mutation_p.D140E|ARHGDIA_ENST00000581876.1_Missense_Mutation_p.D109E|ARHGDIA_ENST00000541078.2_Missense_Mutation_p.D184E|ARHGDIA_ENST00000584461.1_Intron	NM_001185078.1|NM_004309.4	NP_001172007.1|NP_004300.1	P52565	GDIR1_HUMAN	Rho GDP dissociation inhibitor (GDI) alpha	184					anti-apoptosis|cellular component movement|negative regulation of axonogenesis|negative regulation of cell adhesion|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoskeleton|cytosol	GTPase activator activity|identical protein binding|Rho GDP-dissociation inhibitor activity			endometrium(1)|lung(1)|prostate(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGGTCTTGTCGTCGTCTGTGA	0.642000													26	57					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915423	46915423	+	Silent	SNP	C	C	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:46915423C>G	ENST00000307522.3	-	1	1418	c.645G>C	c.(643-645)ccG>ccC	p.P215P		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	215						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GGCCCGCCCTCGGCGCCCAAC	0.711000													14	23					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237777572	237777572	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:237777572C>T	ENST00000366574.2	+	37	5461	c.5144C>T	c.(5143-5145)gCc>gTc	p.A1715V	RYR2_ENST00000360064.6_Missense_Mutation_p.A1713V|RYR2_ENST00000542537.1_Missense_Mutation_p.A1699V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1715	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCTCCTATGCCACTGCCAGG	0.512000													3	33					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745813	96745813	+	Silent	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr10:96745813G>C	ENST00000260682.6	+	8	1185	c.1173G>C	c.(1171-1173)ctG>ctC	p.L391L		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	391					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity	p.L391L(1)		breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TAATTTCCCTGACTTCTGTGC	0.383000													6	63					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8791292	8791292	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr7:8791292G>A	ENST00000405863.1	+	3	1620	c.709G>A	c.(709-711)Gtg>Atg	p.V237M	NXPH1_ENST00000602349.1_Missense_Mutation_p.V120M|NXPH1_ENST00000497400.1_3'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	237	V (Cys-rich).					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GCCCTTTAAGGTGATCTGTAT	0.433000													16	16					0	0	1	0	0
SEPT2	4735	broad.mit.edu	37	2	242265484	242265484	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:242265484G>A	ENST00000391973.2	+	3	614	c.86G>A	c.(85-87)cGa>cAa	p.R29Q	SEPT2_ENST00000402092.2_Missense_Mutation_p.R29Q|SEPT2_ENST00000391971.2_Missense_Mutation_p.R29Q|SEPT2_ENST00000360051.3_Missense_Mutation_p.R29Q|SEPT2_ENST00000401990.1_Missense_Mutation_p.R29Q|SEPT2_ENST00000407971.1_5'UTR	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	29					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		CAAGTTCACCGAAAATCAGTG	0.353000													6	23					0	0	1	0	0
SPACA4	171169	broad.mit.edu	37	19	49110400	49110400	+	Silent	SNP	G	G	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:49110400G>T	ENST00000321762.1	+	1	401	c.165G>T	c.(163-165)ccG>ccT	p.P55P	FAM83E_ENST00000263266.3_Intron	NM_133498.2	NP_598005.1	Q8TDM5	SACA4_HUMAN	sperm acrosome associated 4	55	UPAR/Ly6 1.				cell adhesion	acrosomal vesicle|anchored to membrane|plasma membrane				central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	5		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		GGGTCGCCCCGGGCACTGGTC	0.627000													27	58					2.79863e-10	2.85882e-10	1	1	0
BTN2A1	11120	broad.mit.edu	37	6	26463495	26463495	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:26463495T>C	ENST00000429381.1	+	4	666	c.454T>C	c.(454-456)Tca>Cca	p.S152P	BTN2A1_ENST00000541522.1_Missense_Mutation_p.S91P|BTN2A1_ENST00000312541.5_Missense_Mutation_p.S152P|BTN2A1_ENST00000469185.1_Missense_Mutation_p.S152P			Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	152					lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						GCCCCTCATTTCAATGAGGGG	0.547000													31	57					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2966208	2966208	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr8:2966208G>A	ENST00000602557.1	-	45	7229	c.6674C>T	c.(6673-6675)aCg>aTg	p.T2225M	CSMD1_ENST00000602723.1_Missense_Mutation_p.T2225M|CSMD1_ENST00000400186.3_Missense_Mutation_p.T2225M|CSMD1_ENST00000542608.1_Missense_Mutation_p.T2224M|CSMD1_ENST00000537824.1_Missense_Mutation_p.T2224M|CSMD1_ENST00000520002.1_Missense_Mutation_p.T2225M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2225	CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTATACGCCGTTTCGAGGGC	0.502000													10	7					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37272079	37272079	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr22:37272079C>T	ENST00000397147.4	+	8	1196	c.1012C>T	c.(1012-1014)Cgg>Tgg	p.R338W	NCF4_ENST00000248899.6_Missense_Mutation_p.A256V	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	0					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AGGGACATCGCGGTGGAGGAA	0.607000													11	19					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842837	35842837	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:35842837C>T	ENST00000246553.2	+	1	393	c.383C>T	c.(382-384)gCg>gTg	p.A128V		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	128					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GGGGTGTGCGCGGCCATCTGG	0.667000													22	21					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68696716	68696716	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:68696716G>A	ENST00000255078.3	+	8	1237	c.1126G>A	c.(1126-1128)Gag>Aag	p.E376K		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	376	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGTCATTGACGAGTGTGCCCA	0.652000													10	405					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769658	247769658	+	Silent	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:247769658C>T	ENST00000320002.2	+	1	803	c.771C>T	c.(769-771)taC>taT	p.Y257Y	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y257*(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCATAATCTACGTGTACCTGC	0.473000													24	13					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74704320	74704320	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:74704320C>T	ENST00000261918.4	-	11	1876	c.1328G>A	c.(1327-1329)gGg>gAg	p.G443E	SEMA7A_ENST00000543145.2_Missense_Mutation_p.G429E|SEMA7A_ENST00000542748.1_Missense_Mutation_p.G278E	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	443	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						CTCCTGCTCCCCCGGTTCCAC	0.632000													30	45					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21990749	21990749	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:21990749T>C	ENST00000594012.1	-	7	2586	c.2072A>G	c.(2071-2073)aAg>aGg	p.K691R	ZNF43_ENST00000595461.1_Missense_Mutation_p.K691R|ZNF43_ENST00000354959.4_Missense_Mutation_p.K697R|ZNF43_ENST00000598381.1_Missense_Mutation_p.K691R	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	697					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		ATGAATAATCTTATGTGTAGA	0.348000													18	38					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38710135	38710135	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr22:38710135G>A	ENST00000396832.1	-	2	288	c.28C>T	c.(28-30)Cgc>Tgc	p.R10C	CSNK1E_ENST00000400206.2_Missense_Mutation_p.R10C|CSNK1E_ENST00000413574.2_Missense_Mutation_p.R10C|CSNK1E_ENST00000405675.3_Missense_Mutation_p.R10C|CSNK1E_ENST00000359867.3_Missense_Mutation_p.R10C|CSNK1E_ENST00000403904.1_Missense_Mutation_p.R10C	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	10	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					CGTCCCAGGCGGTACTTGTTC	0.617000													29	28					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26769434	26769434	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr22:26769434G>C	ENST00000404234.3	+	14	3008	c.2812G>C	c.(2812-2814)Gaa>Caa	p.E938Q	SEZ6L_ENST00000402979.1_Missense_Mutation_p.E711Q|SEZ6L_ENST00000494013.1_Intron|SEZ6L_ENST00000360929.3_Intron|SEZ6L_ENST00000529632.2_Intron|SEZ6L_ENST00000343706.4_Intron|SEZ6L_ENST00000403121.1_Intron|SEZ6L_ENST00000411842.2_Intron|SEZ6L_ENST00000248933.6_Missense_Mutation_p.E938Q	NM_001184773.1|NM_021115.4	NP_001171702.1|NP_066938.2	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	938						endoplasmic reticulum membrane|integral to membrane		p.E938K(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						AGACAGTTTTGAACATGCTTT	0.323000													5	26					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3845128	3845128	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr20:3845128C>T	ENST00000428216.2	+	6	979	c.851C>T	c.(850-852)tCc>tTc	p.S284F	MAVS_ENST00000358134.6_3'UTR|MAVS_ENST00000416600.2_Missense_Mutation_p.S143F	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	284					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						ATCATCTGCTCCAGTGGGGCA	0.612000													20	44					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146351241	146351241	+	Silent	SNP	T	T	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:146351241T>C	ENST00000392299.2	+	2	1058	c.588T>C	c.(586-588)acT>acC	p.T196T	GRM1_ENST00000361719.2_Silent_p.T196T|GRM1_ENST00000355289.4_Silent_p.T196T|GRM1_ENST00000492807.2_Silent_p.T196T|GRM1_ENST00000282753.1_Silent_p.T196T|GRM1_ENST00000507907.1_Silent_p.T196T			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	196					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GTGACAAAACTTTGTACAAAT	0.493000													48	78					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49598177	49598177	+	RNA	SNP	T	T	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:49598177T>C	ENST00000527477.1	+	0	781																											GAGGGCTTGGTGTGCTCTGTG	0.522000													6	22					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202742292	202742292	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:202742292C>T	ENST00000367265.3	-	4	1694	c.530G>A	c.(529-531)cGa>cAa	p.R177Q	KDM5B_ENST00000367264.2_Missense_Mutation_p.R177Q	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	177	ARID.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GTTGAGAATTCGTTCATAATG	0.443000													18	41					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120221731	120221731	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr12:120221731G>C	ENST00000392521.2	-	12	1581	c.1526C>G	c.(1525-1527)aCc>aGc	p.T509S	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.T509S	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	509					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTGATGTAGGTAGCAAGGTC	0.552000													11	267					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100817	168100817	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:168100817C>A	ENST00000409195.1	+	9	3004	c.2915C>A	c.(2914-2916)aCa>aAa	p.T972K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.T972K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.T750K|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	797					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAGGAGTTACAAGAGGTGCT	0.358000													34	6					2.09667e-21	2.23801e-21	1	1	0
POTEC	388468	broad.mit.edu	37	18	14513734	14513734	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr18:14513734C>T	ENST00000358970.5	-	10	1459	c.1460G>A	c.(1459-1461)gGa>gAa	p.G487E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	487								p.G487E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTGTGATATTCCAGTGTTCTG	0.323000													4	39					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887743	3887743	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:3887743C>T	ENST00000319331.3	+	2	2179	c.1418C>T	c.(1417-1419)tCa>tTa	p.S473L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	473	Ig-like C2-type.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GAAACCCTTTCAGATAAATAC	0.438000													40	32					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36572337	36572337	+	Silent	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:36572337G>A	ENST00000401500.2	+	10	1271	c.1236G>A	c.(1234-1236)gtG>gtA	p.V412V	WDR62_ENST00000270301.7_Silent_p.V412V|WDR62_ENST00000388999.3_Silent_p.V412V	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	412					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AACTGTAGGTGTATCCTGAGT	0.418000													40	39					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138969205	138969205	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr7:138969205G>T	ENST00000288561.8	+	15	3554	c.3305G>T	c.(3304-3306)aGg>aTg	p.R1102M	UBN2_ENST00000473989.2_Missense_Mutation_p.R1185M	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1185	Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						GGAGCTAATAGGACTAGTCTG	0.493000													10	51					0.00621372	0.00627982	1	1	0
CAD	790	broad.mit.edu	37	2	27448088	27448088	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:27448088G>A	ENST00000264705.4	+	11	1759	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	CAD_ENST00000403525.1_Missense_Mutation_p.E533K	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	533	ATP-grasp 1.|CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GGCCCCGAGCGAGGCAGCAAA	0.493000													8	28					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25849151	25849151	+	Silent	SNP	G	G	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr4:25849151G>T	ENST00000399878.3	-	2	620	c.498C>A	c.(496-498)atC>atA	p.I166I	SEL1L3_ENST00000264868.5_Silent_p.I131I|SEL1L3_ENST00000513364.1_Intron|SEL1L3_ENST00000502949.1_Silent_p.I13I	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	166						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CAGATACAGAGATGGAATGTC	0.403000													12	16					5.16669e-11	5.33517e-11	1	1	0
CASC5	57082	broad.mit.edu	37	15	40913774	40913774	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:40913774G>A	ENST00000346991.5	+	11	1780	c.1390G>A	c.(1390-1392)Gaa>Aaa	p.E464K	CASC5_ENST00000399668.2_Missense_Mutation_p.E438K|CASC5_ENST00000527044.1_3'UTR			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	464	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGATGCCATGGAAATGACCAA	0.348000													32	48					0	0	1	0	0
A4GNT	51146	broad.mit.edu	37	3	137843680	137843680	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:137843680G>A	ENST00000236709.3	-	3	650	c.449C>T	c.(448-450)tCg>tTg	p.S150L		NM_016161.2	NP_057245.1	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	150					protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)	16						GGATGCATCCGAGCTGATGTG	0.567000													32	41					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89735197	89735197	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:89735197G>C	ENST00000343435.5	-	3	578	c.42C>G	c.(40-42)atC>atG	p.I14M	GBP5_ENST00000370459.3_Missense_Mutation_p.I14M|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	14						plasma membrane	GTP binding|GTPase activity	p.I14I(1)		breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAAAGTTCTCGATGAGGCACA	0.478000													44	113					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051072	110051072	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:110051072C>T	ENST00000369864.4	-	2	812	c.463G>A	c.(463-465)Gat>Aat	p.D155N	AMIGO1_ENST00000369862.1_Missense_Mutation_p.D155N			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	155					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCCATGTCATCGAAGGCGCAC	0.542000													51	73					0	0	1	0	0
P2RY13	53829	broad.mit.edu	37	3	151046793	151046793	+	Silent	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:151046793C>T	ENST00000325602.5	-	2	70	c.51G>A	c.(49-51)gtG>gtA	p.V17V	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_176894.2	NP_795713.2	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	17						integral to membrane|plasma membrane				biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			CTTCCAGTGTCACCTGTTACC	0.393000													43	77					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793102	29793102	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr18:29793102C>T	ENST00000269202.6	+	11	1206	c.1159C>T	c.(1159-1161)Ctt>Ttt	p.L387F	MEP1B_ENST00000581447.1_Missense_Mutation_p.L387F	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	387	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GAGCTGGCAACTTTATCATGT	0.393000													20	19					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88119576	88119576	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:88119576G>A	ENST00000507897.1	+	2	102	c.19G>A	c.(19-21)Gaa>Aaa	p.E7K	C6ORF165_ENST00000369562.4_Missense_Mutation_p.E7K			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	7										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AACTCAGGCCGAAAGTGTTAT	0.333000													19	38					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130376371	130376371	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:130376371G>C	ENST00000529410.1	+	10	1117	c.638G>C	c.(637-639)aGa>aCa	p.R213T	L3MBTL3_ENST00000361794.2_Missense_Mutation_p.R213T|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.R188T|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.R188T|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.R188T|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.R213T			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	213					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CGGAGGAAAAGACGAGGGGAT	0.383000													9	38					0	0	1	0	0
CTCF	10664	broad.mit.edu	37	16	67650756	67650756	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr16:67650756C>T	ENST00000264010.4	+	5	1505	c.1061C>T	c.(1060-1062)tCc>tTc	p.S354F	CTCF_ENST00000401394.1_Missense_Mutation_p.S26F	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	354					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding	p.S354F(1)		breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TTCAAGTGTTCCATGTGCGAT	0.453000													95	156					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321664	90321664	+	Silent	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr9:90321664G>A	ENST00000469640.2	+	27	4128	c.3753G>A	c.(3751-3753)acG>acA	p.T1251T	DAPK1_ENST00000472284.1_Silent_p.T1226T|DAPK1_ENST00000408954.3_Silent_p.T1226T|DAPK1_ENST00000358077.5_Silent_p.T1226T|DAPK1_ENST00000491893.1_Silent_p.T1160T			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1226					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity	p.T1226T(2)|p.T1227T(2)		breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TGGCCACCACGCTGCCAGGGC	0.627000									Chronic Lymphocytic Leukemia, Familial Clustering of				6	20					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10270532	10270532	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:10270532G>A	ENST00000340748.4	-	15	1343	c.1108C>T	c.(1108-1110)Cac>Tac	p.H370Y	DNMT1_ENST00000359526.4_Missense_Mutation_p.H386Y|DNMT1_ENST00000540357.1_Missense_Mutation_p.H370Y			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	370	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCTGGTGGGTGCTGCCCATAT	0.602000													8	229					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103321010	103321010	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:103321010C>T	ENST00000233969.2	+	10	1995	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	618						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CAGACTTTATCCTACAACAGA	0.418000													16	47					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60688430	60688430	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:60688430G>A	ENST00000227525.3	+	3	713	c.310G>A	c.(310-312)Gca>Aca	p.A104T	TMEM109_ENST00000536171.1_Missense_Mutation_p.A104T|RP11-881M11.4_ENST00000543907.1_RNA	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	104						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						TGGGATCGCCGCACAGCTGCT	0.537000													5	126					0	0	1	0	0
LIPN	643418	broad.mit.edu	37	10	90528636	90528636	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr10:90528636C>T	ENST00000404459.1	+	5	623	c.623C>T	c.(622-624)cCc>cTc	p.P208L		NM_001102469.1	NP_001095939.1	Q5VXI9	LIPN_HUMAN	lipase, family member N	208					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|skin(1)	9		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		TTCAAATATCCCACGGGCATT	0.403000													9	9					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40181971	40181971	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr21:40181971G>A	ENST00000360214.3	+	3	473	c.13G>A	c.(13-15)Gga>Aga	p.G5R	ETS2_ENST00000360938.3_Missense_Mutation_p.G5R	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	5					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				GAATGATTTCGGAATCAAGAA	0.373000													4	16					0	0	1	0	0
OSGIN2	734	broad.mit.edu	37	8	90937310	90937310	+	Silent	SNP	C	C	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr8:90937310C>G	ENST00000451899.2	+	6	1460	c.1200C>G	c.(1198-1200)gtC>gtG	p.V400V	OSGIN2_ENST00000297438.2_Silent_p.V356V	NM_001126111.1	NP_001119583.1	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family member 2	356					germ cell development|meiosis					breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(11;0.0344)			ATCATAAAGTCTATCATATGA	0.383000													35	102					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125033801	125033801	+	Silent	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr8:125033801C>T	ENST00000522917.1	+	17	2231	c.2025C>T	c.(2023-2025)tgC>tgT	p.C675C	FER1L6_ENST00000399018.1_Silent_p.C675C|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	675						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCAATGTGCAAGGAGGCCA	0.453000													39	173					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967215	21967215	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr14:21967215G>A	ENST00000298717.4	-	10	1736	c.1585C>T	c.(1585-1587)Cgc>Tgc	p.R529C	TOX4_ENST00000405508.1_3'UTR|TOX4_ENST00000262709.3_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	529					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		TCAATCTTGCGAGTGCCAGGA	0.413000													27	34					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48719141	48719141	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:48719141T>A	ENST00000294129.2	-	5	790	c.671A>T	c.(670-672)gAc>gTc	p.D224V	NCKIPSD_ENST00000416649.2_Missense_Mutation_p.D217V|NCKIPSD_ENST00000341520.4_Missense_Mutation_p.D224V	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	224	Pro-rich.|Ser/Thr-rich.				cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATAGAGCGTGTCCAGGGAGGT	0.647000													12	6					0	0	1	0	0
RPS24	6229	broad.mit.edu	37	10	79797023	79797023	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr10:79797023C>T	ENST00000360830.4	+	4	370	c.351C>T	c.(349-351)gtC>gtT	p.117_117insV	RPS24_ENST00000476545.1_3'UTR|RPS24_ENST00000440692.1_Silent_p.V117V|RPS24_ENST00000435275.1_Silent_p.V117V|RPS24_ENST00000372360.3_Silent_p.V117V			P62847	RS24_HUMAN	ribosomal protein S24	0					endocrine pancreas development|erythrocyte homeostasis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	nucleotide binding|structural constituent of ribosome|translation initiation factor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(2)|skin(1)	5	all_cancers(46;0.0343)|all_epithelial(25;0.000959)|Breast(12;0.00113)|Prostate(51;0.0095)		Epithelial(14;0.00128)|OV - Ovarian serous cystadenocarcinoma(4;0.00248)|all cancers(16;0.00428)			TGAAGAAAGTCAGGGGGACTG	0.398000													3	2					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578508	7578508	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr17:7578508C>T	ENST00000420246.2	-	5	554	c.422G>A	c.(421-423)tGc>tAc	p.C141Y	TP53_ENST00000269305.4_Missense_Mutation_p.C141Y|TP53_ENST00000445888.2_Missense_Mutation_p.C141Y|TP53_ENST00000413465.2_Missense_Mutation_p.C141Y|TP53_ENST00000359597.4_Missense_Mutation_p.C141Y|TP53_ENST00000455263.2_Missense_Mutation_p.C141Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	141	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> A (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(79)|p.0?(8)|p.C9Y(5)|p.C48Y(5)|p.A138_P142delAKTCP(4)|p.C141F(4)|p.C141S(3)|p.N131fs*27(2)|p.C9S(1)|p.K139_C141>N(1)|p.L137_W146del10(1)|p.C141A(1)|p.A6_P10delAKTCP(1)|p.K139fs*4(1)|p.A45_P49delAKTCP(1)|p.T140fs*28(1)|p.A138_V143delAKTCPV(1)|p.C48S(1)|p.C141fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGCACAGGGCAGGTCTTGGC	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	12					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927081	130927081	+	Silent	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr12:130927081G>A	ENST00000261655.4	-	8	928	c.765C>T	c.(763-765)tcC>tcT	p.S255S	RIMBP2_ENST00000535703.1_Silent_p.S163S|RIMBP2_ENST00000536002.1_Silent_p.S163S	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	255						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGCCGATGCCGGAATGGTTGA	0.597000													4	107					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76572371	76572371	+	Silent	SNP	T	T	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:76572371T>G	ENST00000369981.3	+	16	1884	c.1605T>G	c.(1603-1605)ctT>ctG	p.L535L	MYO6_ENST00000369985.4_Silent_p.L535L|MYO6_ENST00000369975.1_Silent_p.L535L|MYO6_ENST00000369977.3_Silent_p.L535L			Q9UM54	MYO6_HUMAN	myosin VI	535	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAAATCGCCTTCCCCAGCCAA	0.353000													24	13					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79655040	79655040	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:79655040T>G	ENST00000275034.4	-	39	4972	c.4805A>C	c.(4804-4806)aAg>aCg	p.K1602T	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1602					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AGCTGATGACTTTGAAAGAGT	0.358000													34	68					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661336	77661336	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr4:77661336G>C	ENST00000296043.6	+	5	2963	c.2010G>C	c.(2008-2010)gaG>gaC	p.E670D		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	670					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ACATTCCTGAGAGTCTGAGAA	0.597000													55	85					0	0	1	0	0
IFI44L	10964	broad.mit.edu	37	1	79107493	79107493	+	Nonstop_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:79107493G>C	ENST00000370751.4	+	9	1537	c.1358G>C	c.(1357-1359)tGa>tCa	p.*453S	IFI44L_ENST00000342282.3_Nonstop_Mutation_p.*195S|IFI44L_ENST00000476521.1_3'UTR	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	0						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						CCCTGCATTTGAGATAAGTTG	0.428000													44	83					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25226143	25226143	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr8:25226143C>G	ENST00000276440.7	+	33	3384	c.3340C>G	c.(3340-3342)Ctg>Gtg	p.L1114V		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1114						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GGAGGTCACTCTGACCCCTGA	0.408000													20	15					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11231182	11231182	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr19:11231182G>A	ENST00000558518.1	+	14	2311	c.2124G>A	c.(2122-2124)atG>atA	p.M708I	LDLR_ENST00000455727.2_Missense_Mutation_p.M540I|LDLR_ENST00000557933.1_Missense_Mutation_p.M708I|LDLR_ENST00000558013.1_Missense_Mutation_p.M708I|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000535915.1_Missense_Mutation_p.M667I	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	708	EGF-like 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CCAGGGACATGAGGAGCTGCC	0.627000													23	28					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563188	55563188	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:55563188A>G	ENST00000335605.1	+	1	157	c.157A>G	c.(157-159)Att>Gtt	p.I53V		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				AATAATCAAGATTAACCCCAA	0.388000													17	51					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213057	13213057	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr10:13213057C>T	ENST00000378694.1	+	2	218	c.143C>T	c.(142-144)gCc>gTc	p.A48V	MCM10_ENST00000378714.3_Missense_Mutation_p.A48V|MCM10_ENST00000484800.2_Missense_Mutation_p.A48V			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	48					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						CTCTTTGATGCCGACGGCGAC	0.458000													5	128					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71522211	71522211	+	Silent	SNP	T	T	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr4:71522211T>A	ENST00000254801.4	-	4	484	c.315A>T	c.(313-315)atA>atT	p.I105I	IGJ_ENST00000543780.1_Silent_p.I121I|ENAM_ENST00000472903.1_Intron	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	105					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			TAGCAGTAACTATCTGATTAT	0.418000													14	26					0	0	1	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490503	48490503	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr4:48490503G>A	ENST00000273861.4	+	3	1080	c.861G>A	c.(859-861)atG>atA	p.M287I		NM_152679.3	NP_689892.1	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	287						integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	6						CCGGCACTATGTTAGGACCTG	0.433000													50	80					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916210	149916210	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:149916210G>C	ENST00000369135.3	-	12	2372	c.2078C>G	c.(2077-2079)cCt>cGt	p.P693R		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	693					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			AAAGTCCCCAGGGTAGCCAGT	0.647000													52	25					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52684525	52684525	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr13:52684525C>T	ENST00000355568.4	-	7	557	c.418G>A	c.(418-420)Gga>Aga	p.G140R		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	140	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GCCACCATTCCGTTCTTGCTA	0.353000													27	32					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185332487	185332487	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:185332487G>C	ENST00000296257.5	+	11	1309	c.1069G>C	c.(1069-1071)Gag>Cag	p.E357Q	SENP2_ENST00000545472.1_Missense_Mutation_p.E347Q|SENP2_ENST00000427465.2_Missense_Mutation_p.E181Q	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	357					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CTCAGGCAAAGAGAGGGACAG	0.438000													18	36					0	0	1	0	0
RIOK2	55781	broad.mit.edu	37	5	96503372	96503372	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr5:96503372G>T	ENST00000283109.3	-	8	1264	c.1196C>A	c.(1195-1197)gCt>gAt	p.A399D	CTD-2215E18.1_ENST00000509481.1_Intron|RIOK2_ENST00000508447.1_Missense_Mutation_p.A399D	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	399	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TTCTTCTAAAGCTTGATTGAA	0.373000													33	13					1.30897e-18	1.36651e-18	1	1	0
DCHS1	8642	broad.mit.edu	37	11	6645063	6645063	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:6645063G>A	ENST00000299441.3	-	21	8255	c.7844C>T	c.(7843-7845)aCa>aTa	p.T2615I		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2615	Cadherin 25.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCAACAGGTGTGTCCTCAGG	0.567000													32	139					0	0	1	0	0
ADCK3	56997	broad.mit.edu	37	1	227149148	227149148	+	Missense_Mutation	SNP	C	C	T	rs142184584		TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:227149148C>T	ENST00000366779.1	+	7	2833	c.62C>T	c.(61-63)gCg>gTg	p.A21V	ADCK3_ENST00000366778.1_Intron|ADCK3_ENST00000458507.2_Intron|ADCK3_ENST00000366777.3_Missense_Mutation_p.A21V|ADCK3_ENST00000478406.1_Intron|ADCK3_ENST00000366776.1_Missense_Mutation_p.A21V|ADCK3_ENST00000366775.1_5'UTR			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	21					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						CTGACCCAGGCGGCCGTGGAA	0.617000													50	15					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													4	61					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53889440	53889440	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:53889440G>A	ENST00000396328.1	-	18	3223	c.2984C>T	c.(2983-2985)gCg>gTg	p.A995V	WDR72_ENST00000557913.1_Missense_Mutation_p.A992V|WDR72_ENST00000559418.1_Missense_Mutation_p.A1005V|WDR72_ENST00000360509.5_Missense_Mutation_p.A995V	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	995										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTGAACTTCCGCCAAGAGAAC	0.373000													44	96					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1712669	1712669	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chrX:1712669G>C	ENST00000313871.3	+	2	510	c.314G>C	c.(313-315)gGc>gCc	p.G105A	AKAP17A_ENST00000381261.3_Missense_Mutation_p.G105A	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	105	PKA-RI and PKA-RII subunit binding domain.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						AAGCTCAGCGGCTTCTCCGAC	0.602000													87	131					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr17:39261693A>T	ENST00000391415.1	+	1	110	c.53A>T	c.(52-54)gAc>gTc	p.D18V		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament		p.D18V(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGCGGCCAAGACCTCTGTCAG	0.627000													4	57					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32959825	32959825	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr17:32959825G>A	ENST00000321639.5	+	7	1643	c.1315G>A	c.(1315-1317)Gaa>Aaa	p.E439K		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	439						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		TGCTCCCCTGGAAATGACAGT	0.582000													91	133					0	0	1	0	0
CACYBP	27101	broad.mit.edu	37	1	174979205	174979205	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:174979205C>T	ENST00000367681.2	+	6	1188	c.548C>T	c.(547-549)aCg>aTg	p.T183M	CACYBP_ENST00000367679.2_Missense_Mutation_p.T226M|CACYBP_ENST00000405362.1_Missense_Mutation_p.T183M	NM_001007214.1	NP_001007215.1	Q9HB71	CYBP_HUMAN	calcyclin binding protein	226	Interaction with S100A6 (By similarity).|Interaction with SKP1.|SGS.			T -> P (in Ref. 4; AAG23817).		beta-catenin destruction complex	protein homodimerization activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)	11						AAAGGAGACACGGAATTTTGA	0.368000													19	49					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41203625	41203625	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chrX:41203625G>C	ENST00000399959.2	+	10	1853	c.998G>C	c.(997-999)aGa>aCa	p.R333T	DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000478993.1_3'UTR|DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000457138.2_Missense_Mutation_p.R317T	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	333	Helicase ATP-binding.|Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						ATGATGGAAAGAGGAAAGATT	0.383000										HNSCC(61;0.18)			61	46					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86831499	86831499	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:86831499T>C	ENST00000237455.4	-	4	2493	c.1525A>G	c.(1525-1527)Att>Gtt	p.I509V	RNF103-CHMP3_ENST00000604011.1_Intron|AC015971.2_ENST00000597638.1_RNA|AC015971.2_ENST00000439077.1_RNA|CHMP3_ENST00000439940.2_Intron|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000424788.1_RNA	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	509					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						AAGTTTTTAATATAATCAGTT	0.433000													60	102					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99308496	99308496	+	Silent	SNP	G	G	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr7:99308496G>C	ENST00000336374.2	-	10	887	c.885C>G	c.(883-885)ctC>ctG	p.L295L		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	295					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					ATTGGGCCATGAGCTCCAGAT	0.413000													23	40					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58062871	58062871	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr3:58062871G>T	ENST00000357272.4	+	2	556	c.391G>T	c.(391-393)Gaa>Taa	p.E131*	FLNB_ENST00000490882.1_Nonsense_Mutation_p.E131*|FLNB_ENST00000295956.4_Nonsense_Mutation_p.E131*|FLNB_ENST00000358537.3_Nonsense_Mutation_p.E131*|FLNB_ENST00000429972.2_Nonsense_Mutation_p.E131*|FLNB_ENST00000348383.5_Nonsense_Mutation_p.E131*			O75369	FLNB_HUMAN	filamin B, beta	131	Actin-binding.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTGGGAGGATGAAGGGGATGA	0.527000													48	20					2.64894e-19	2.79611e-19	1	1	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	69					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92671628	92671628	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:92671628A>C	ENST00000318445.6	+	7	1635	c.1421A>C	c.(1420-1422)aAc>aCc	p.N474T	SLCO3A1_ENST00000555549.1_3'UTR|SLCO3A1_ENST00000424469.2_Missense_Mutation_p.N474T	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	474	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TGCAATAATAACTGTGAATGC	0.522000													30	139					0	0	1	0	0
SCRT1	83482	broad.mit.edu	37	8	145559793	145559793	+	Silent	SNP	G	G	A			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr8:145559793G>A	ENST00000332135.4	-	1	150	c.39C>T	c.(37-39)gaC>gaT	p.D13D		NM_031309.4	NP_112599.1	Q9BWW7	SCRT1_HUMAN	scratch family zinc finger 1	13						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|upper_aerodigestive_tract(1)	3	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.35e-39)|all cancers(56;1.37e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			AAGAGAACGCGTCAAGTTTGA	0.692000													8	30					0	0	1	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062449	66062449	+	Silent	SNP	C	C	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr11:66062449C>T	ENST00000327259.4	+	2	876	c.732C>T	c.(730-732)agC>agT	p.S244S		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	244						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						GCTTCTTCAGCGCCAACGAGG	0.687000													5	14					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	24					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283609	33283609	+	Missense_Mutation	SNP	C	C	T	rs147840428	by1000genomes	TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:33283609C>T	ENST00000431845.2	-	2	1236	c.1085G>A	c.(1084-1086)cGt>cAt	p.R362H	ZBTB22_ENST00000418724.1_Missense_Mutation_p.R362H	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						ACTCAGGGTACGGACATCACT	0.577000													57	76					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184842	19184842	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr7:19184842C>G	ENST00000275461.3	-	1	202	c.144G>C	c.(142-144)gaG>gaC	p.E48D	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	48					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						TGGGTCTTCCCTCTCGGAGCG	0.657000													70	39					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	-	C			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr1:28800272_28800273insC	ENST00000373839.3	+	7	1291_1292	c.1030_1031insC	c.(1030-1032)cccfs	p.P344fs	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Frame_Shift_Ins_p.P354fs	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity	p.P356fs*33(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													8	256	---	---	---	---					
TNS1	7145	broad.mit.edu	37	2	218712887	218712889	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr2:218712887_218712889delGCT	ENST00000171887.4	-	17	2428_2430	c.1976_1978delAGC	c.(1975-1980)cct>c	p.QP659del	TNS1_ENST00000419504.1_In_Frame_Del_p.QP659del|TNS1_ENST00000430930.1_In_Frame_Del_p.QP659del	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	659	Gln-rich.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTGGGCGAGgctgctgctgctg	0.660													7	27	---	---	---	---					
HDAC2	3066	broad.mit.edu	37	6	114262884	114262885	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr6:114262884_114262885insT	ENST00000519065.1	-	13	1799_1800	c.1423_1424insA	c.(1423-1425)agafs	p.R475fs	HDAC2_ENST00000398283.2_Frame_Shift_Ins_p.R569fs|HDAC2_ENST00000519108.1_Frame_Shift_Ins_p.R445fs|HDAC2_ENST00000368632.2_Frame_Shift_Ins_p.R445fs			Q92769	HDAC2_HUMAN	histone deacetylase 2	475					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	TTTGGTATCTGTTTTTTCACCA	0.282													7	14	---	---	---	---					
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs72025661		TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr15:78913068_78913070delCAG	ENST00000326828.5	-	1	451_453	c.67_69delCTG	c.(67-69)del	p.L23del	CHRNA3_ENST00000348639.3_In_Frame_Del_p.L23del	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						gcagcagagacagcagcagcagc	0.768													4	3	---	---	---	---					
MKL1	57591	broad.mit.edu	37	22	40816887	40816889	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-QK-A6IH-01A-11D-A31L-08	TCGA-QK-A6IH-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4a12f44d-7d6c-4480-9ffa-c80356f78232	30897199-87f7-452c-ab03-987cbd2c50e7	g.chr22:40816887_40816889delTGC	ENST00000396617.3	-	10	1433_1435	c.843_845delGCA	c.(841-846)cac>ca	p.QH281del	MKL1_ENST00000407029.1_In_Frame_Del_p.QH281del|MKL1_ENST00000402042.1_In_Frame_Del_p.QH231del|MKL1_ENST00000355630.3_In_Frame_Del_p.QH281del			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	281	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GTAGTTGTGGTGCTGCTGCTGCT	0.660			T	RBM15	acute megakaryocytic leukemia								7	76	---	---	---	---