Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SIRPG	55423	broad.mit.edu	37	20	1629713	1629713	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr20:1629713C>T	ENST00000381580.1	-	2	495	c.316G>A	c.(316-318)Gag>Aag	p.E106K	SIRPG_ENST00000344103.4_Missense_Mutation_p.E139K|SIRPG_ENST00000381583.2_Missense_Mutation_p.E139K|SIRPG_ENST00000216927.4_Missense_Mutation_p.E139K|SIRPG_ENST00000303415.3_Missense_Mutation_p.E139K			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	139	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						AAAGCCATCTCAGTGCCTGGT	0.483000													27	157					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1565827	1565827	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:1565827G>A	ENST00000357210.4	+	20	3175	c.2959G>A	c.(2959-2961)Gca>Aca	p.A987T	MIB2_ENST00000355826.5_Missense_Mutation_p.A1030T|MIB2_ENST00000520777.1_Missense_Mutation_p.A1040T|MIB2_ENST00000378712.1_3'UTR|MIB2_ENST00000505820.2_Missense_Mutation_p.A1044T|MIB2_ENST00000504599.1_Missense_Mutation_p.A943T|MIB2_ENST00000378708.1_Missense_Mutation_p.A893T|MIB2_ENST00000360522.4_Missense_Mutation_p.A952T|MIB2_ENST00000378710.3_Missense_Mutation_p.A951T|MIB2_ENST00000518681.1_Missense_Mutation_p.A979T	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	987					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CGGCCACGGCGCATGCGCCCC	0.706000													3	15					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264947	231264947	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:231264947G>C	ENST00000243810.6	+	15	1303	c.1303G>C	c.(1303-1305)Gaa>Caa	p.E435Q	SP140L_ENST00000444636.1_Missense_Mutation_p.E435Q|SP140L_ENST00000415673.2_Missense_Mutation_p.E435Q|SP140L_ENST00000396563.4_Missense_Mutation_p.E400Q			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	435						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						CCCACCTGTGGAAAGTGAGAA	0.522000													6	51					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42022469	42022469	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr4:42022469A>G	ENST00000264451.6	+	4	551	c.371A>G	c.(370-372)aAg>aGg	p.K124R		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	124					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TATGGCTCAAAGTACACTCAG	0.333000													25	136					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:7577022G>A	ENST00000420246.2	-	8	1048	c.916C>T	c.(916-918)Cga>Tga	p.R306*	TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.R306*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R306*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R306*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R306*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	306	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(133)|p.0?(8)|p.?(3)|p.R306fs*39(2)|p.K305fs*1(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562000	R306*(HCC1937_BREAST)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(MFE296_ENDOMETRIUM)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	71					0	0	1	0	0
TMEM132C	92293	broad.mit.edu	37	12	128899675	128899675	+	Missense_Mutation	SNP	G	G	A	rs142699896	by1000genomes	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr12:128899675G>A	ENST00000435159.2	+	2	484	c.484G>A	c.(484-486)Ggc>Agc	p.G162S		NM_001136103.2	NP_001129575.2	Q8N3T6	T132C_HUMAN	transmembrane protein 132C	162						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(2)|prostate(2)|skin(1)	13						GGATGACCACGGCGCCGGGGA	0.597000													4	11					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89357577	89357577	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:89357577C>A	ENST00000301030.4	-	5	701	c.241G>T	c.(241-243)Gag>Tag	p.E81*	ANKRD11_ENST00000378330.2_Nonsense_Mutation_p.E81*	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	81						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCTTCCGCTCAGGGCCCTGC	0.607000													8	73					7.48243e-07	7.88149e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179425532	179425532	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:179425532C>T	ENST00000589042.1	-	326	85551	c.85327G>A	c.(85327-85329)Gtt>Att	p.V28443I	TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V26802I|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V19378I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V19570I|TTN_ENST00000342992.6_Missense_Mutation_p.V25875I|TTN_ENST00000359218.5_Missense_Mutation_p.V19503I|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26802	Fibronectin type-III 107.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCAATTAACGGCCACAGAC	0.458000													20	37					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826630	46826630	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:46826630G>A	ENST00000283296.7	-	17	3298	c.3010C>T	c.(3010-3012)Cct>Tct	p.P1004S	GPR116_ENST00000545669.1_Missense_Mutation_p.P433S|GPR116_ENST00000456426.2_Missense_Mutation_p.P862S|GPR116_ENST00000362015.4_Missense_Mutation_p.P1004S|GPR116_ENST00000265417.7_Missense_Mutation_p.P1004S	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1004					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AGAGAACTAGGATCTGGGGAG	0.488000													9	101					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150948293	150948293	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr5:150948293C>G	ENST00000261800.5	-	1	212	c.200G>C	c.(199-201)tGg>tCg	p.W67S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	67	Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTCACTGCCCACTGTGGCTC	0.478000													9	242					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96370416	96370416	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr12:96370416G>C	ENST00000261208.3	-	19	2091	c.1723C>G	c.(1723-1725)Ccg>Gcg	p.P575A	HAL_ENST00000541929.1_Missense_Mutation_p.P367A|HAL_ENST00000538703.1_Missense_Mutation_p.P575A	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	575					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TTCTCCAGCGGAGTGGTTGTT	0.498000													17	68					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3085380	3085380	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:3085380G>A	ENST00000397461.1	+	22	3187	c.2803G>A	c.(2803-2805)Gga>Aga	p.G935R	CNTN4_ENST00000427331.1_Missense_Mutation_p.G935R|CNTN4_ENST00000418658.1_Missense_Mutation_p.G935R|CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000448906.2_Missense_Mutation_p.G607R|CNTN4_ENST00000397459.2_Missense_Mutation_p.G607R|CNTN4_ENST00000358480.3_Missense_Mutation_p.G716R	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	935	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GGAAGTAAAAGGATACAAAGT	0.423000													8	53					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101489468	101489468	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:101489468C>G	ENST00000370483.5	-	2	164	c.114G>C	c.(112-114)ttG>ttC	p.L38F	CUTC_ENST00000493385.1_Intron|COX15_ENST00000016171.5_Missense_Mutation_p.L38F	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	38					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		GCCCTGGCCTCAAAGGGCGCC	0.507000													16	55					0	0	1	0	0
TMEM30A	55754	broad.mit.edu	37	6	75968511	75968511	+	Silent	SNP	A	A	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:75968511A>G	ENST00000230461.6	-	6	1206	c.877T>C	c.(877-879)Ttg>Ctg	p.L293L	TMEM30A_ENST00000370050.5_Silent_p.L174L|TMEM30A_ENST00000475111.2_Silent_p.L257L	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	293						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTGACATTCAAAGAGTATCGG	0.403000													3	77					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3979393	3979393	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr19:3979393G>A	ENST00000309311.6	-	11	1735	c.1647C>T	c.(1645-1647)gcC>gcT	p.A549A		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	549						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCTCGCCGGCGCCCGCGA	0.657000													36	52					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197636551	197636551	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:197636551C>T	ENST00000263956.3	-	15	2270	c.2181G>A	c.(2179-2181)ctG>ctA	p.L727L		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	727						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CTGGGTTTTTCAGCATCAAAC	0.428000													15	67					0	0	1	0	0
NUCKS1	64710	broad.mit.edu	37	1	205687512	205687512	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:205687512C>A	ENST00000367142.4	-	7	930	c.628G>T	c.(628-630)Gag>Tag	p.E210*		NM_022731.4	NP_073568.2	Q9H1E3	NUCKS_HUMAN	nuclear casein kinase and cyclin-dependent kinase substrate 1	210						nucleus				endometrium(4)|large_intestine(1)|lung(9)	14	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TCCGGTTCCTCATCTTCTTCT	0.522000													31	246					1.45844e-13	1.63427e-13	1	1	0
TCTN3	26123	broad.mit.edu	37	10	97452743	97452743	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:97452743G>A	ENST00000265993.8	-	3	676	c.433C>T	c.(433-435)Ccg>Tcg	p.P145S	TCTN3_ENST00000430368.1_Missense_Mutation_p.P145S|TCTN3_ENST00000371209.5_Missense_Mutation_p.P145S|TCTN3_ENST00000371217.4_Missense_Mutation_p.P163S	NM_015631.5	NP_056446.4	Q6NUS6	TECT3_HUMAN	tectonic family member 3	145					apoptosis	integral to membrane				breast(3)|endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		GAAGGAAACGGGGAATTACTC	0.428000													3	42					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15623319	15623319	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr9:15623319G>C	ENST00000380701.3	+	7	1058	c.730G>C	c.(730-732)Gaa>Caa	p.E244Q	CCDC171_ENST00000535968.1_Missense_Mutation_p.E244Q|CCDC171_ENST00000297641.3_Missense_Mutation_p.E244Q	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	244	Glu-rich.																ATTAGAAACAGAACATATGGA	0.348000													5	131					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41159280	41159280	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr5:41159280C>A	ENST00000263413.3	-	12	2024	c.1760G>T	c.(1759-1761)cGa>cTa	p.R587L	C6_ENST00000337836.5_Missense_Mutation_p.R587L	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	587	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTGCATTCTCGGGTTCTCGA	0.493000													16	144					4.96729e-08	5.30292e-08	1	1	0
OR5P3	120066	broad.mit.edu	37	11	7846689	7846689	+	Missense_Mutation	SNP	G	G	C	rs450205		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:7846689G>C	ENST00000328375.1	-	1	830	c.831C>G	c.(829-831)ttC>ttG	p.F277L	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCACGGTGTAGAACACAGACA	0.458000													16	90					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242572369	242572369	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:242572369G>A	ENST00000407315.1	-	2	1634	c.1203C>T	c.(1201-1203)agC>agT	p.S401S		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	401							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GATAGGGGACGCTCACTCTCC	0.622000													7	23					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38211742	38211742	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr22:38211742A>G	ENST00000323205.6	+	7	1028	c.965A>G	c.(964-966)aAc>aGc	p.N322S	GCAT_ENST00000248924.6_Missense_Mutation_p.N296S	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	296					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTCTTCTCCAACAGTCTGCCA	0.637000													32	189					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084299	99084299	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:99084299C>G	ENST00000331410.5	+	5	736	c.466C>G	c.(466-468)Caa>Gaa	p.Q156E	ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000448667.1_3'UTR	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGGCTTCCTTCAAAACCTTAA	0.403000													19	89					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234529144	234529144	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:234529144G>A	ENST00000040877.1	-	28	4523	c.4524C>T	c.(4522-4524)ctC>ctT	p.L1508L	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1508					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CAGAGACACTGAGGTGCTGAA	0.483000													5	41					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19410511	19410511	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chrX:19410511C>G	ENST00000338883.4	-	17	2274	c.2275G>C	c.(2275-2277)Gag>Cag	p.E759Q	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Missense_Mutation_p.E591Q|MAP3K15_ENST00000359173.3_Missense_Mutation_p.E194Q	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	759	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TTAAGGCCCTCCAGGATCTGT	0.453000													50	137					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24578255	24578255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr4:24578255G>A	ENST00000336812.4	-	2	274	c.118C>T	c.(118-120)Cga>Tga	p.R40*		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	40					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				TCTCGGTCTCGATCTTTAGAC	0.433000													26	40					0	0	1	0	0
TAF2	6873	broad.mit.edu	37	8	120774829	120774829	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr8:120774829C>T	ENST00000378164.2	-	19	2682	c.2384G>A	c.(2383-2385)cGt>cAt	p.R795H	TAF2_ENST00000519355.1_5'UTR	NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	795					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATTTCTGCACGATAATAGTT	0.323000													11	72					0	0	1	0	0
ELAVL1	1994	broad.mit.edu	37	19	8028517	8028517	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr19:8028517G>A	ENST00000407627.2	-	6	960	c.831C>T	c.(829-831)cgC>cgT	p.R277R	ELAVL1_ENST00000596459.1_Silent_p.R277R|ELAVL1_ENST00000593807.1_3'UTR|ELAVL1_ENST00000351593.5_Silent_p.R304R	NM_001419.2	NP_001410.2	Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	277	RRM 3.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGTTGAAGTCGCGGATCACTT	0.547000													81	99					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235993528	235993528	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:235993528G>A	ENST00000389794.3	-	3	364	c.190C>T	c.(190-192)Cag>Tag	p.Q64*	LYST_ENST00000536965.1_Nonsense_Mutation_p.Q64*|LYST_ENST00000389793.2_Nonsense_Mutation_p.Q64*			Q99698	LYST_HUMAN	lysosomal trafficking regulator	64					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AATGTTACCTGATCAATTATA	0.373000													16	46					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584223	82584223	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:82584223C>G	ENST00000423517.2	-	5	6383	c.6046G>C	c.(6046-6048)Gag>Cag	p.E2016Q	PCLO_ENST00000333891.8_Missense_Mutation_p.E2016Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1947					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTTCTAACTCATAAAACTCT	0.378000													33	110					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101716803	101716803	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:101716803G>A	ENST00000342239.3	-	4	519	c.428C>T	c.(427-429)cCg>cTg	p.P143L	DNMBP_ENST00000324109.4_Missense_Mutation_p.P143L|DNMBP-AS1_ENST00000434409.1_RNA			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	143					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GGAATATTCCGGAATCTGAAA	0.582000													13	55					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4881985	4881985	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:4881985C>T	ENST00000321919.9	-	5	608	c.532G>A	c.(532-534)Gag>Aag	p.E178K	GLYR1_ENST00000381983.3_Missense_Mutation_p.E178K|GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000591451.1_Missense_Mutation_p.E178K	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	178					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						CAAACCTTCTCATCCTTTGGG	0.488000													14	57					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94911876	94911876	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:94911876G>C	ENST00000536441.1	-	7	1390	c.1054C>G	c.(1054-1056)Cag>Gag	p.Q352E	RP11-712B9.2_ENST00000534864.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.Q213E|RP11-712B9.2_ENST00000534891.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	352					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TATTATACCTGAGCTCGGAAT	0.338000													14	53					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70516064	70516064	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:70516064G>C	ENST00000265872.6	+	14	1779	c.1660G>C	c.(1660-1662)Gag>Cag	p.E554Q	CCAR1_ENST00000483264.1_3'UTR|CCAR1_ENST00000535016.1_Missense_Mutation_p.E539Q|CCAR1_ENST00000543719.1_Missense_Mutation_p.E539Q	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	554					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						CCATCGCCCTGAGGAGACCCA	0.473000													4	67					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113623085	113623085	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:113623085A>G	ENST00000358160.4	+	8	1247	c.755A>G	c.(754-756)gAa>gGa	p.E252G	GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000472026.1_Missense_Mutation_p.E85G|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.E47G|GRAMD1C_ENST00000479212.1_3'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	252						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						CGGGTTTCAGAAACAGAGTCA	0.363000													22	69					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55883641	55883641	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:55883641G>C	ENST00000521992.1	-	12	1550	c.1405C>G	c.(1405-1407)Cag>Gag	p.Q469E	CES5A_ENST00000518005.1_Missense_Mutation_p.Q334E|CES5A_ENST00000520435.1_Missense_Mutation_p.Q410E|CES5A_ENST00000290567.9_Missense_Mutation_p.Q440E|CES5A_ENST00000319165.9_Intron|CES5A_ENST00000541580.1_5'UTR	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	440						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity	p.Q469K(1)		breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TCAAAGCACTGAGGCCGGTGC	0.557000													36	67					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4755233	4755233	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:4755233G>C	ENST00000304283.4	-	8	1025	c.731C>G	c.(730-732)tCt>tGt	p.S244C	ANKS3_ENST00000585773.1_Missense_Mutation_p.S171C|ANKS3_ENST00000450067.2_Missense_Mutation_p.S38C|ANKS3_ENST00000446014.2_Missense_Mutation_p.S115C	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	244										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						CTCGTCAGAAGAGCTCAGATC	0.502000													18	64					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725567	32725567	+	Missense_Mutation	SNP	C	C	T	rs114234640	byFrequency	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:32725567C>T	ENST00000435145.2	-	4	801	c.740G>A	c.(739-741)cGt>cAt	p.R247H	HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.R247H|HLA-DQB2_ENST00000411527.1_Intron			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						ACCCCTGTGACGGATGATAAG	0.552000													7	35					0	0	1	0	0
KRTAP5-2	440021	broad.mit.edu	37	11	1619301	1619301	+	Silent	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:1619301G>C	ENST00000412090.1	-	1	223	c.180C>G	c.(178-180)gtC>gtG	p.V60V	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	60						keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCAGCAGCAGACAGGCACAT	0.687000													6	270					0	0	1	0	0
ULBP2	80328	broad.mit.edu	37	6	150267599	150267599	+	Silent	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:150267599C>A	ENST00000367351.3	+	3	514	c.441C>A	c.(439-441)atC>atA	p.I147I		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	147	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		ATGGGCAGATCTTCCTCCTCT	0.507000													8	239					5.18039e-06	5.38488e-06	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33328669	33328669	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr20:33328669C>T	ENST00000374796.2	-	12	7961	c.5391G>A	c.(5389-5391)ttG>ttA	p.L1797L	NCOA6_ENST00000359003.2_Silent_p.L1797L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1797	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GACTATTGGTCAAAAGGGGAG	0.488000													18	105					0	0	1	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15352138	15352138	+	RNA	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr21:15352138G>A	ENST00000344693.5	-	0	620					NR_027270.1																						TCCGAGTACCGGATTCGGTAC	0.627000													7	21					0	0	1	0	0
MTHFR	4524	broad.mit.edu	37	1	11856353	11856353	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:11856353G>T	ENST00000376592.1	-	4	818	c.690C>A	c.(688-690)ttC>ttA	p.F230L	MTHFR_ENST00000376583.3_Missense_Mutation_p.F271L|MTHFR_ENST00000376590.3_Missense_Mutation_p.F230L|MTHFR_ENST00000376585.1_Missense_Mutation_p.F271L			P42898	MTHR_HUMAN	methylenetetrahydrofolate reductase (NAD(P)H)	230					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding			NS(4)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	CAGCCTCAAAGAAAAGCTGCG	0.572000													114	261					2.55378e-55	2.90286e-55	1	1	0
EPS15	2060	broad.mit.edu	37	1	51910602	51910602	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:51910602G>C	ENST00000371733.3	-	11	1009	c.913C>G	c.(913-915)Cct>Gct	p.P305A	EPS15_ENST00000371730.2_Missense_Mutation_p.P305A	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	305	EH 3.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						ATCATTTCAGGAGTAAGAACG	0.393000			T	MLL	ALL								72	132					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6373655	6373655	+	Silent	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:6373655G>T	ENST00000262483.8	-	13	1785	c.1698C>A	c.(1696-1698)ccC>ccA	p.P566P	ACKR6_ENST00000576664.1_5'UTR|ACKR6_ENST00000421306.3_Silent_p.P530P	NM_031220.3	NP_112497.2																					GGGCCACGGTGGGGAAGGCCG	0.622000													24	24					1.66031e-10	1.80916e-10	1	1	0
OR52N4	390072	broad.mit.edu	37	11	5776386	5776386	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:5776386C>A	ENST00000317254.3	+	1	464	c.416C>A	c.(415-417)aCc>aAc	p.T139N	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		ACTATCCTCACCAATCCTGTA	0.507000													15	139					1.3612e-06	1.42431e-06	1	1	0
ANKFN1	162282	broad.mit.edu	37	17	54535256	54535256	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:54535256G>A	ENST00000566473.2	+	13	1482	c.1482G>A	c.(1480-1482)ctG>ctA	p.L494L	ANKFN1_ENST00000318698.2_Silent_p.L494L			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	494										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TAAGGTGGCTGAGGCAAAGCA	0.478000													29	88					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133312019	133312019	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr12:133312019G>A	ENST00000539605.1	-	8	8171	c.1487C>T	c.(1486-1488)cCg>cTg	p.P496L	ANKLE2_ENST00000357997.5_Missense_Mutation_p.P558L|ANKLE2_ENST00000542374.1_5'UTR|ANKLE2_ENST00000337516.5_Missense_Mutation_p.P558L			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	558						cytoplasm|integral to membrane|nuclear envelope		p.P558Q(1)		NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GCCTCTTTCCGGGTCCGACTT	0.478000													31	117					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7797866	7797866	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:7797866C>T	ENST00000380358.4	+	8	1387	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	CHD3_ENST00000358181.4_Silent_p.L403L|CHD3_ENST00000330494.7_Silent_p.L403L	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	403					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CCTACCACCTCGTCTGCCTTG	0.567000													5	148					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815706	158815706	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:158815706C>T	ENST00000368141.4	+	5	1161	c.900C>T	c.(898-900)atC>atT	p.I300I		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	300	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					ACAGAATTATCGAAATAGCAA	0.343000													49	62					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73925519	73925519	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr15:73925519G>A	ENST00000351217.6	-	1	956	c.38C>T	c.(37-39)tCg>tTg	p.S13L	NPTN_ENST00000345330.4_Missense_Mutation_p.S13L|NPTN_ENST00000564551.1_5'UTR|NPTN_ENST00000562924.1_Missense_Mutation_p.S13L|NPTN_ENST00000287226.8_Missense_Mutation_p.S13L|NPTN_ENST00000563691.1_Missense_Mutation_p.S13L|NPTN_ENST00000545878.1_Missense_Mutation_p.S13L|NPTN_ENST00000542234.1_Missense_Mutation_p.S13L	NM_001161364.1|NM_017455.3	NP_001154836.1|NP_059429.1	Q9Y639	NPTN_HUMAN	neuroplastin	13					elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						CAGCAACAGCGAGAGGGCCAG	0.746000													4	15					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50935382	50935382	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr14:50935382G>T	ENST00000013125.4	-	10	979	c.661C>A	c.(661-663)Ctc>Atc	p.L221I		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	221	Protein kinase.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					ATTGGGTGGAGATCAAACATA	0.393000													9	44					0.000673444	0.000682078	1	1	0
CEP63	80254	broad.mit.edu	37	3	134264494	134264494	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:134264494C>T	ENST00000337090.3	+	7	795	c.622C>T	c.(622-624)Cac>Tac	p.H208Y	CEP63_ENST00000332047.5_Missense_Mutation_p.H208Y|CEP63_ENST00000606977.1_Missense_Mutation_p.H208Y|CEP63_ENST00000513612.2_Missense_Mutation_p.H208Y|CEP63_ENST00000383229.3_Missense_Mutation_p.H208Y|CEP63_ENST00000354446.3_Missense_Mutation_p.H208Y			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	208					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AGAAATTCAACACTTAAGCAG	0.428000													23	113					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200956005	200956005	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:200956005C>G	ENST00000332129.2	-	26	3972	c.3656G>C	c.(3655-3657)aGa>aCa	p.R1219T	KIF21B_ENST00000422435.2_Missense_Mutation_p.R1219T|KIF21B_ENST00000461742.2_Missense_Mutation_p.R1219T|KIF21B_ENST00000360529.5_Missense_Mutation_p.R1219T	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1219					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GGACTTCCTTCTCGTCAGCGG	0.547000													24	71					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29220963	29220963	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:29220963G>T	ENST00000321990.4	+	21	5470	c.5092G>T	c.(5092-5094)Gat>Tat	p.D1698Y		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1698					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGAGAGTAATGATGGATGGAC	0.378000													32	91					5.60225e-13	6.23349e-13	1	1	0
CDH9	1007	broad.mit.edu	37	5	26903856	26903856	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr5:26903856C>G	ENST00000231021.4	-	6	1061	c.889G>C	c.(889-891)Gtg>Ctg	p.V297L		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	297	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTTCCCCCACGTCAGGGTCA	0.413000													39	229					0	0	1	0	0
FAAH	2166	broad.mit.edu	37	1	46870755	46870755	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:46870755C>G	ENST00000243167.8	+	3	463	c.379C>G	c.(379-381)Cag>Gag	p.Q127E	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	127					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	TCAGCTGTCTCAGGCCCCAAG	0.562000													20	76					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3085632	3085632	+	Silent	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:3085632G>T	ENST00000259808.4	+	6	1126	c.828G>T	c.(826-828)ccG>ccT	p.P276P	RIPK1_ENST00000380409.2_Silent_p.P276P|RIPK1_ENST00000479389.1_3'UTR|RIPK1_ENST00000541791.1_Silent_p.P230P			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	276	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				AAGCTCGGCCGACATTTCCTG	0.468000													27	52					3.73988e-18	4.22073e-18	1	1	0
FOXD4L1	200350	broad.mit.edu	37	2	114256927	114256927	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:114256927G>C	ENST00000306507.5	+	1	267	c.94G>C	c.(94-96)Gag>Cag	p.E32Q		NM_012184.4	NP_036316.1	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	32					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(2)	26						TGTCCTGGGAgaggaggaaga	0.647000													32	101					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129233286	129233286	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:129233286G>A	ENST00000296266.3	+	26	3387	c.3195G>A	c.(3193-3195)ctG>ctA	p.L1065L	IFT122_ENST00000507564.1_Silent_p.L1007L|IFT122_ENST00000504021.1_Silent_p.L891L|IFT122_ENST00000440957.2_Silent_p.L805L|IFT122_ENST00000431818.2_Silent_p.L864L|IFT122_ENST00000349441.2_Silent_p.L904L|IFT122_ENST00000348417.2_Silent_p.L1014L|IFT122_ENST00000347300.2_Silent_p.L955L	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1014					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CCTACAGGCTGGCCCGGCACG	0.602000													14	60					0	0	1	0	0
UBE2I	7329	broad.mit.edu	37	16	1364314	1364314	+	Silent	SNP	A	A	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:1364314A>C	ENST00000355803.4	+	3	638	c.87A>C	c.(85-87)acA>acC	p.T29T	UBE2I_ENST00000566587.1_Silent_p.T29T|UBE2I_ENST00000397514.3_Silent_p.T29T|UBE2I_ENST00000325437.5_Silent_p.T29T|UBE2I_ENST00000403747.2_Silent_p.T29T|UBE2I_ENST00000397515.2_Silent_p.T29T|UBE2I_ENST00000406620.1_Silent_p.T29T|UBE2I_ENST00000402301.1_Silent_p.T29T	NM_194260.2	NP_919236.1	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	29					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	5		Hepatocellular(780;0.00369)				CTGTCCCAACAAAAAATCCCG	0.547000													23	42					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173526508	173526508	+	Missense_Mutation	SNP	C	C	T	rs141463661	byFrequency	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:173526508C>T	ENST00000367714.3	-	10	1608	c.1186G>A	c.(1186-1188)Gct>Act	p.A396T	SLC9C2_ENST00000466087.1_5'UTR|RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Missense_Mutation_p.A294T	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	396					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TTTCGTTCAGCGAGATTATAA	0.353000													26	185					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226574040	226574040	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:226574040G>A	ENST00000366794.5	-	6	964	c.821C>T	c.(820-822)tCt>tTt	p.S274F		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	274					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CGACTCCCCAGAAGGCACTTG	0.537000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					16	54					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81972454	81972454	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:81972454C>A	ENST00000359376.3	+	29	3461	c.3247C>A	c.(3247-3249)Ccc>Acc	p.P1083T		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1083	C2.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TATTGCCTGTCCCTTTGTAGA	0.527000													10	58					9.70103e-10	1.0427e-09	1	1	0
PALLD	23022	broad.mit.edu	37	4	169846389	169846389	+	Nonsense_Mutation	SNP	C	C	T	rs145720372		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr4:169846389C>T	ENST00000261509.6	+	20	3524	c.3313C>T	c.(3313-3315)Cga>Tga	p.R1105*	PALLD_ENST00000512127.1_Intron|PALLD_ENST00000335742.7_Intron|PALLD_ENST00000505667.1_Nonsense_Mutation_p.R1122*|PALLD_ENST00000507735.1_Intron|CBR4_ENST00000509108.1_Intron	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1329					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGTAGTTTCTCGACATTAATA	0.313000									Pancreatic Cancer, Familial Clustering of				48	200					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55839108	55839108	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:55839108C>T	ENST00000373965.2	-	18	2489	c.2095G>A	c.(2095-2097)Gat>Aat	p.D699N	PCDH15_ENST00000395430.1_Missense_Mutation_p.D692N|PCDH15_ENST00000437009.1_Missense_Mutation_p.D621N|PCDH15_ENST00000395446.1_Missense_Mutation_p.D692N|PCDH15_ENST00000395433.1_Missense_Mutation_p.D670N|PCDH15_ENST00000409834.1_Missense_Mutation_p.D303N|PCDH15_ENST00000373955.1_Missense_Mutation_p.D692N|PCDH15_ENST00000395445.1_Missense_Mutation_p.D699N|PCDH15_ENST00000395432.2_Missense_Mutation_p.D655N|PCDH15_ENST00000320301.6_Missense_Mutation_p.D692N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Missense_Mutation_p.D670N|PCDH15_ENST00000414778.1_Missense_Mutation_p.D697N|PCDH15_ENST00000395438.1_Missense_Mutation_p.D692N|PCDH15_ENST00000361849.3_Missense_Mutation_p.D692N	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	692	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGCCTGCCATCTGAAGCTGTG	0.433000										HNSCC(58;0.16)			6	196					0	0	1	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149857997	149857997	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:149857997G>C	ENST00000369155.2	-	1	235	c.194C>G	c.(193-195)tCc>tGc	p.S65C		NM_003528.2	NP_003519.1	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	65					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	14	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GTTGACGAAGGAGTTCATGAT	0.607000													48	187					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35672472	35672472	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr13:35672472G>A	ENST00000400445.3	+	11	2144	c.1610G>A	c.(1609-1611)aGt>aAt	p.S537N	NBEA_ENST00000310336.4_Missense_Mutation_p.S537N|NBEA_ENST00000379939.2_Missense_Mutation_p.S537N|NBEA_ENST00000540320.1_Missense_Mutation_p.S537N	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	537						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTACTTAAAAGTTCAGTAGCC	0.368000													10	4					0	0	1	0	0
INSL6	11172	broad.mit.edu	37	9	5185550	5185550	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr9:5185550C>T	ENST00000381641.3	-	1	118	c.53G>A	c.(52-54)cGg>cAg	p.R18Q		NM_007179.2	NP_009110.2	Q9Y581	INSL6_HUMAN	insulin-like 6	18						extracellular region	hormone activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(2)	15	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		ACGAGAAAACCGAACCAGCAG	0.597000													4	26					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52255539	52255539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:52255539G>A	ENST00000494383.1	-	5	3252	c.3253C>T	c.(3253-3255)Caa>Taa	p.Q1085*	TLR9_ENST00000360658.2_Silent_p.R931R|TLR9_ENST00000597542.1_Silent_p.R955R			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	ACAGCGTCTTGCGGCTGCCAT	0.672000													53	51					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16142160	16142160	+	Splice_Site	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:16142160G>A	ENST00000399408.2	+	10	1555	c.1380_splice	c.e10+1	p.L460_splice	ABCC1_ENST00000399410.3_Splice_Site_p.L460_splice|ABCC1_ENST00000345148.5_Splice_Site_p.L460_splice|ABCC1_ENST00000346370.5_Splice_Site_p.L460_splice|ABCC1_ENST00000349029.5_Splice_Site_p.L460_splice|ABCC1_ENST00000351154.5_Splice_Site_p.L460_splice			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	460	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCCTGTGGCTGGTGTGTGTTT	0.552000													25	98					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800982	185800982	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:185800982G>A	ENST00000302277.6	+	4	1453	c.859G>A	c.(859-861)Gac>Aac	p.D287N		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	287						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AATGTGCAGAGACAAAGAAAC	0.373000													22	77					0	0	1	0	0
FAM69C	125704	broad.mit.edu	37	18	72103933	72103933	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr18:72103933G>A	ENST00000343998.6	-	4	1071	c.1063C>T	c.(1063-1065)Cgc>Tgc	p.R355C	FAM69C_ENST00000400291.2_Missense_Mutation_p.R56C	NM_001044369.2	NP_001037834.2	Q0P6D2	FA69C_HUMAN	family with sequence similarity 69, member C	355						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(2)|ovary(2)	5						AACCAATGGCGAAATATTTTG	0.522000													6	28					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10471966	10471966	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr18:10471966G>A	ENST00000355285.4	+	3	1036	c.682G>A	c.(682-684)Gag>Aag	p.E228K	APCDD1_ENST00000584596.1_3'UTR|APCDD1_ENST00000578882.1_Intron	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	228					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		CCACCTGGTCGAGGAGCTCTT	0.567000													41	184					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226836413	226836413	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:226836413G>C	ENST00000429204.1	-	3	2319	c.1992C>G	c.(1990-1992)ttC>ttG	p.F664L	ITPKB_ENST00000272117.3_Missense_Mutation_p.F664L	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	664							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				ACTTCTTCTTGAAGGACATGA	0.493000													32	110					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776710	150776710	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:150776710G>A	ENST00000540185.1	-	2	884	c.280C>T	c.(280-282)Cgg>Tgg	p.R94W	FASTK_ENST00000353841.2_Intron|FASTK_ENST00000489884.1_Intron|FASTK_ENST00000482571.1_Missense_Mutation_p.R128W|FASTK_ENST00000297532.6_Missense_Mutation_p.R128W			Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	128					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GGCCGTGGCCGAGACCCCAAG	0.647000													7	27					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7993298	7993298	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:7993298G>T	ENST00000377507.3	-	7	769	c.603C>A	c.(601-603)ttC>ttA	p.F201L		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	201					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		AGAACAGCAGGAAGAGCAACG	0.438000													4	61					0.00909568	0.00915361	1	1	0
EEF1A1	1915	broad.mit.edu	37	6	74227810	74227810	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:74227810C>G	ENST00000316292.9	-	6	2198	c.1207G>C	c.(1207-1209)Gat>Cat	p.D403H	EEF1A1_ENST00000309268.6_Missense_Mutation_p.D403H|EEF1A1_ENST00000491404.1_Intron|EEF1A1_ENST00000331523.2_Missense_Mutation_p.D403H	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	403						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						GGAACCATATCAACAATGGCA	0.423000											OREG0003893	type=REGULATORY REGION|Gene=BC038897|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	14					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971138	21971138	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr9:21971138C>T	ENST00000579755.1	-	2	555	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	CDKN2A_ENST00000530628.2_Missense_Mutation_p.R88Q|CDKN2A_ENST00000494262.1_Missense_Mutation_p.D23N|CDKN2A_ENST00000497750.1_Missense_Mutation_p.D23N|CDKN2A_ENST00000579122.1_Missense_Mutation_p.D74N|CDKN2A_ENST00000498124.1_Missense_Mutation_p.D74N|CDKN2A_ENST00000304494.5_Missense_Mutation_p.D74N|CDKN2A_ENST00000446177.1_Missense_Mutation_p.D74N|CDKN2A_ENST00000498628.2_Missense_Mutation_p.D23N|CDKN2A_ENST00000361570.3_Missense_Mutation_p.R129Q|CDKN2A_ENST00000578845.2_Missense_Mutation_p.D23N|CDKN2A_ENST00000479692.2_Missense_Mutation_p.D23N|RP11-145E5.5_ENST00000404796.2_Intron			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	144			E -> D (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.D74Y(5)|p.D74N(2)|p.E61_L94del(1)|p.0(1)|p.V59fs*45(1)|p.L65fs*38(1)|p.A68fs*3(1)|p.C72fs*71(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GTGGCGGGGTCGGCGCAGTTG	0.711000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			13	3					0	0	1	0	0
GINS2	51659	broad.mit.edu	37	16	85721081	85721081	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:85721081C>G	ENST00000253462.3	-	2	290	c.190G>C	c.(190-192)Gag>Cag	p.E64Q		NM_016095.2	NP_057179.1	Q9Y248	PSF2_HUMAN	GINS complex subunit 2 (Psf2 homolog)	64					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)	6						TCCATCCACTCTGGAGGGAGC	0.607000													16	108					0	0	1	0	0
MRPS17	51373	broad.mit.edu	37	7	56020972	56020972	+	Silent	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:56020972G>C	ENST00000285298.4	+	2	213	c.84G>C	c.(82-84)gtG>gtC	p.V28V	MRPS17_ENST00000426595.1_Silent_p.V123V	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	28					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTGCTAAAGTGAGAGTGACCA	0.468000													25	148					0	0	1	0	0
OXT	5020	broad.mit.edu	37	20	3052340	3052340	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr20:3052340C>T	ENST00000217386.2	+	1	75	c.39C>T	c.(37-39)ctC>ctT	p.L13L		NM_000915.2	NP_000906.1	P01178	NEU1_HUMAN	oxytocin/neurophysin I prepropeptide	13					signal transduction		neurohypophyseal hormone activity			lung(2)	2					Oxytocin(DB00107)	TGCTCGGCCTCCTGGCGCTGA	0.701000													5	12					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115970681	115970681	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:115970681G>A	ENST00000251864.2	+	13	1768	c.1615G>A	c.(1615-1617)Gat>Aat	p.D539N	TDRD1_ENST00000422662.1_Missense_Mutation_p.D200N|TDRD1_ENST00000369282.1_Missense_Mutation_p.D539N|TDRD1_ENST00000369280.1_Missense_Mutation_p.D539N|TDRD1_ENST00000369281.2_Missense_Mutation_p.D539N	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	539					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TCCACGCTCTGATTTTTATCC	0.348000													19	56					0	0	1	0	0
ANGPTL3	27329	broad.mit.edu	37	1	63064454	63064454	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:63064454C>T	ENST00000371129.3	+	2	663	c.583C>T	c.(583-585)Caa>Taa	p.Q195*	DOCK7_ENST00000404627.2_Intron|DOCK7_ENST00000251157.5_Intron|DOCK7_ENST00000340370.5_Intron	NM_014495.2	NP_055310.1	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3	195					acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|urinary_tract(1)	13						ACAGCATAGTCAAATAAAAGA	0.318000													12	57					0	0	1	0	0
RAD51B	5890	broad.mit.edu	37	14	68352616	68352616	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr14:68352616C>T	ENST00000487270.1	+	6	531	c.483C>T	c.(481-483)ccC>ccT	p.P161P	RAD51B_ENST00000488612.1_Silent_p.P161P|RAD51B_ENST00000390683.3_Silent_p.P161P|RAD51B_ENST00000487861.1_Silent_p.P161P|RAD51B_ENST00000471583.1_Silent_p.P161P	NM_133509.3	NP_598193.2	O15315	RA51B_HUMAN	RAD51 paralog B	161					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity		HMGA2/RAD51B(11)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11						CCCGTTTTCCCAGATATTTTA	0.363000								Direct reversal of damage					34	233					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157068947	157068947	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:157068947C>T	ENST00000454449.2	-	2	566	c.282G>A	c.(280-282)ctG>ctA	p.L94L		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	94						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GGGCCCGGCTCAGCTTGTCAT	0.582000													20	75					0	0	1	0	0
MSI1	4440	broad.mit.edu	37	12	120789176	120789176	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr12:120789176G>T	ENST00000257552.2	-	11	849	c.761C>A	c.(760-762)cCg>cAg	p.P254Q		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	254					nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGGGCGCTCGGGAGAGGGGT	0.562000													3	31					1	1	1	1	0
WNT5A	7474	broad.mit.edu	37	3	55508406	55508406	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr3:55508406G>A	ENST00000474267.1	-	5	1164	c.643C>T	c.(643-645)Cgc>Tgc	p.R215C	WNT5A_ENST00000497027.1_Missense_Mutation_p.R200C|WNT5A_ENST00000264634.4_Missense_Mutation_p.R215C			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	215					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		ATGAGGATGCGAGCACTCTCG	0.657000													17	13					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142714007	142714007	+	RNA	SNP	T	T	C	rs1694635	by1000genomes	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:142714007T>C	ENST00000369381.2	-	0	598																											GATATCCAACTGGAGAAAAAG	0.303000													5	18					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134261178	134261178	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:134261178C>A	ENST00000457545.2	+	9	1081	c.821C>A	c.(820-822)gCc>gAc	p.A274D	AKR1B15_ENST00000423958.1_Missense_Mutation_p.A246D	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	274							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						AAAACCACAGCCCAGGTACCA	0.458000													10	52					7.48243e-07	7.88149e-07	1	1	0
RNF213	57674	broad.mit.edu	37	17	78320894	78320894	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:78320894C>T	ENST00000582970.1	+	29	8902	c.8759C>T	c.(8758-8760)tCa>tTa	p.S2920L	RNF213_ENST00000508628.2_Missense_Mutation_p.S2969L|RNF213_ENST00000336301.6_Missense_Mutation_p.S993L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATCTGCTCCTCAGACATCCTC	0.567000													8	27					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25121477	25121477	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr22:25121477T>C	ENST00000332271.5	-	17	2458	c.2042A>G	c.(2041-2043)tAc>tGc	p.Y681C	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.Y563C|PIWIL3_ENST00000533313.1_Missense_Mutation_p.Y563C	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	681	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ACATTGAGAGTACCACCTGTT	0.413000													36	61					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57823951	57823951	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr15:57823951G>C	ENST00000281282.5	+	14	3343	c.3265G>C	c.(3265-3267)Gag>Cag	p.E1089Q		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	1089						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TTTGCTGTCTGAGAGGATCAG	0.443000													17	60					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332743	70332743	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:70332743C>T	ENST00000338508.4	-	32	3657	c.3658G>A	c.(3658-3660)Gca>Aca	p.A1220T	SHANK2_ENST00000449833.2_Missense_Mutation_p.A624T|SHANK2_ENST00000409161.1_Missense_Mutation_p.A623T|SHANK2_ENST00000423696.2_Missense_Mutation_p.A840T			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	840					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GCGGAGAGTGCCAGGGCCAGC	0.637000													6	460					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136249652	136249652	+	Translation_Start_Site	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr9:136249652G>A	ENST00000371955.1	+	0	248				C9orf96_ENST00000371957.3_Missense_Mutation_p.D63N|C9orf96_ENST00000426926.2_Missense_Mutation_p.D63N|C9orf96_ENST00000468046.1_3'UTR			Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96								ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGAATGCATGGATGACCATTA	0.493000													33	110					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100395746	100395746	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:100395746C>G	ENST00000281806.2	-	3	598	c.284G>C	c.(283-285)cGa>cCa	p.R95P	MCHR2_ENST00000445970.1_Missense_Mutation_p.R95P|MCHR2_ENST00000369212.1_Missense_Mutation_p.R95P	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	95						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTCTCCCCCTCGGGCCCATTG	0.488000													29	104					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25284224	25284224	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr20:25284224C>A	ENST00000339157.5	-	11	1263	c.991G>T	c.(991-993)Gag>Tag	p.E331*	ABHD12_ENST00000376542.3_Nonsense_Mutation_p.E331*	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	331						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						GGGTCGTCCTCAGCGTGCAGG	0.617000													14	66					6.72482e-11	7.37863e-11	1	1	0
SLC29A1	2030	broad.mit.edu	37	6	44197355	44197355	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:44197355G>C	ENST00000393841.1	+	5	632	c.141G>C	c.(139-141)caG>caC	p.Q47H	SLC29A1_ENST00000371713.1_Missense_Mutation_p.Q47H|SLC29A1_ENST00000371755.3_Missense_Mutation_p.Q47H|SLC29A1_ENST00000371724.1_Missense_Mutation_p.Q47H|SLC29A1_ENST00000371740.5_Missense_Mutation_p.Q47H|SLC29A1_ENST00000371731.1_Missense_Mutation_p.Q47H|SLC29A1_ENST00000393844.1_Missense_Mutation_p.Q47H|SLC29A1_ENST00000371708.1_Missense_Mutation_p.Q47H|SLC29A1_ENST00000313248.7_Missense_Mutation_p.Q126H|SLC29A1_ENST00000427851.2_Missense_Mutation_p.Q47H|SLC29A1_ENST00000472176.1_3'UTR	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	47					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	ACATGTCCCAGAATGTGTCCT	0.562000													12	61					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185701488	185701488	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr4:185701488C>G	ENST00000515030.1	-	5	800	c.475G>C	c.(475-477)Gag>Cag	p.E159Q	ACSL1_ENST00000504342.1_Missense_Mutation_p.E159Q|ACSL1_ENST00000454703.2_5'UTR|ACSL1_ENST00000437665.3_5'UTR|ACSL1_ENST00000281455.2_Missense_Mutation_p.E159Q|ACSL1_ENST00000507295.1_Intron|ACSL1_ENST00000504900.1_Missense_Mutation_p.E159Q|ACSL1_ENST00000513317.1_Missense_Mutation_p.E159Q			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	159					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTTCATACCTCAGGTCTATTT	0.433000													5	187					0	0	1	0	0
GGA1	26088	broad.mit.edu	37	22	38027078	38027078	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr22:38027078C>G	ENST00000406772.1	+	15	1933	c.1281C>G	c.(1279-1281)atC>atG	p.I427M	GGA1_ENST00000337437.4_Missense_Mutation_p.I467M|GGA1_ENST00000343632.4_Missense_Mutation_p.I500M|GGA1_ENST00000381756.5_Missense_Mutation_p.I517M|GGA1_ENST00000325180.8_Missense_Mutation_p.I413M	NM_001172688.1	NP_001166159.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	500	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					TGGCCAGCATCACTGTGCCCC	0.667000													20	103					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	rs28934575		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:7577548C>T	ENST00000420246.2	-	7	865	c.733G>A	c.(733-735)Ggc>Agc	p.G245S	TP53_ENST00000413465.2_Missense_Mutation_p.G245S|TP53_ENST00000269305.4_Missense_Mutation_p.G245S|TP53_ENST00000445888.2_Missense_Mutation_p.G245S|TP53_ENST00000359597.4_Missense_Mutation_p.G245S|TP53_ENST00000455263.2_Missense_Mutation_p.G245S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(304)|p.G245C(59)|p.G245R(10)|p.G152S(8)|p.0?(8)|p.?(5)|p.G152C(4)|p.G244_M246>V(3)|p.G245N(2)|p.G245fs*2(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245fs*22(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577000	G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKLMS1_SOFT_TISSUE)|G245S(SKMEL2_SKIN)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			32	64					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237729947	237729947	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:237729947G>A	ENST00000366574.2	+	28	3612	c.3295G>A	c.(3295-3297)Gga>Aga	p.G1099R	RYR2_ENST00000542537.1_Missense_Mutation_p.G1083R|RYR2_ENST00000360064.6_Missense_Mutation_p.G1097R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1099	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGTGAAGGCCGGACGGTGGTA	0.552000													4	169					0	0	1	0	0
SGK2	10110	broad.mit.edu	37	20	42213636	42213636	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr20:42213636G>A	ENST00000373100.1	+	14	1544	c.1084G>A	c.(1084-1086)Gat>Aat	p.D362N	SGK2_ENST00000373077.1_Missense_Mutation_p.D361N|SGK2_ENST00000373092.3_Missense_Mutation_p.D362N|SGK2_ENST00000423407.3_Missense_Mutation_p.D362N|SGK2_ENST00000426287.1_Missense_Mutation_p.D388N|SGK2_ENST00000341458.4_Missense_Mutation_p.D422N			Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2	422	AGC-kinase C-terminal.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GCCAGAGGATGATGACATCTT	0.507000													5	125					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234454536	234454536	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:234454536G>C	ENST00000366618.3	+	6	1139	c.994G>C	c.(994-996)Gaa>Caa	p.E332Q	SLC35F3_ENST00000366617.3_Missense_Mutation_p.E263Q	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	263					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TAAGTTTGGAGAAGCCGCCTT	0.468000													39	170					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89261437	89261437	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:89261437C>T	ENST00000289746.2	+	14	2384	c.2319C>T	c.(2317-2319)ttC>ttT	p.F773F		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	773					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGCCCCGCTTCGCCCGGCTGG	0.672000													6	18					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969076	47969076	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr19:47969076C>T	ENST00000236877.6	-	2	980	c.585G>A	c.(583-585)ctG>ctA	p.L195L	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	195					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AGAAGACTCTCAGGTGCTTGA	0.552000													15	28					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89719083	89719083	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr15:89719083G>C	ENST00000352732.5	+	6	1099	c.579G>C	c.(577-579)aaG>aaC	p.K193N	ABHD2_ENST00000565973.1_Missense_Mutation_p.K193N|ABHD2_ENST00000355100.3_Missense_Mutation_p.K193N	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	193						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					ACTACATCAAGAAGACATATC	0.507000													19	87					0	0	1	0	0
R3HDM2	22864	broad.mit.edu	37	12	57662214	57662214	+	Silent	SNP	A	A	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr12:57662214A>G	ENST00000402412.1	-	18	2292	c.1902T>C	c.(1900-1902)aaT>aaC	p.N634N	RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000413953.2_Silent_p.N347N|R3HDM2_ENST00000403821.2_Silent_p.N654N|R3HDM2_ENST00000358907.2_Silent_p.N620N|R3HDM2_ENST00000393811.2_Silent_p.N347N|R3HDM2_ENST00000347140.3_Silent_p.N620N|R3HDM2_ENST00000441731.2_Silent_p.N315N|R3HDM2_ENST00000546843.1_5'UTR			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	620	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GCTGGACCACATTTTGCGAGT	0.527000													19	55					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067721	190067721	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:190067721G>A	ENST00000367462.3	-	8	1959	c.1728C>T	c.(1726-1728)ttC>ttT	p.F576F	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.F474F	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		576						extracellular region		p.F576F(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGCTGCCTCCGAAGGGATTGA	0.463000													5	151					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598490	68598490	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:68598490G>C	ENST00000570495.1	+	5	2092	c.1800G>C	c.(1798-1800)caG>caC	p.Q600H	ZFP90_ENST00000563169.2_Missense_Mutation_p.Q600H|RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.Q600H			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	600					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		ATGATCATCAGAGAATTCATA	0.408000													5	292					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52496987	52496987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr19:52496987G>A	ENST00000602063.1	-	6	1691	c.1342C>T	c.(1342-1344)Cga>Tga	p.R448*	ZNF615_ENST00000594083.1_Nonsense_Mutation_p.R459*|ZNF615_ENST00000391795.3_Nonsense_Mutation_p.R453*|ZNF615_ENST00000376716.5_Nonsense_Mutation_p.R448*|ZNF615_ENST00000598071.1_Nonsense_Mutation_p.R459*			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GTATGTGTTCGCTGATGTCTG	0.443000													6	61					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90509416	90509416	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr14:90509416C>T	ENST00000335725.4	+	17	2006	c.1756C>T	c.(1756-1758)Cgg>Tgg	p.R586W	TDP1_ENST00000555880.1_Silent_p.I549I|TDP1_ENST00000393454.2_Missense_Mutation_p.R586W|TDP1_ENST00000393452.3_3'UTR|TDP1_ENST00000357382.3_Missense_Mutation_p.R347W	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	586					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TCCCCCAGATCGGCCATGGAT	0.418000								Repair of DNA-protein crosslinks					26	60					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8819162	8819162	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr18:8819162G>A	ENST00000359865.3	+	13	3203	c.3061G>A	c.(3061-3063)Gag>Aag	p.E1021K	SOGA2_ENST00000517570.1_Missense_Mutation_p.E980K|SOGA2_ENST00000306329.11_Missense_Mutation_p.E1340K|SOGA2_ENST00000400050.3_Missense_Mutation_p.E980K|SOGA2_ENST00000518815.1_Missense_Mutation_p.E346K|SOGA2_ENST00000306285.7_Missense_Mutation_p.E346K	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1331																	CTCGGCCAGTGAGAATCTCTA	0.617000													12	72					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62340160	62340160	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:62340160G>A	ENST00000378019.3	-	2	307	c.217C>T	c.(217-219)Cag>Tag	p.Q73*	MIR3654_ENST00000496634.2_3'UTR|EEF1G_ENST00000532986.1_5'UTR|EEF1G_ENST00000329251.4_Nonsense_Mutation_p.Q23*			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	23	GST N-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCGCTGTACTGAGCAGCGATG	0.547000													17	104					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69934314	69934314	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:69934314G>T	ENST00000358913.5	+	11	2953	c.2465G>T	c.(2464-2466)cGg>cTg	p.R822L	MYPN_ENST00000354393.2_Missense_Mutation_p.R547L|MYPN_ENST00000540630.1_Missense_Mutation_p.R822L	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	822	Pro-rich.					nucleus|sarcomere	actin binding	p.R822Q(1)		breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CCTACCAGCCGGATTCAGAAC	0.557000													11	47					3.86212e-05	3.98833e-05	1	1	0
MTNR1A	4543	broad.mit.edu	37	4	187455656	187455656	+	Silent	SNP	C	C	T	rs149418383	byFrequency	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr4:187455656C>T	ENST00000307161.5	-	2	441	c.240G>A	c.(238-240)ccG>ccA	p.P80P	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	80					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	CCAACGGGTACGGATAAATGG	0.502000													10	54					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51772275	51772275	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr15:51772275G>A	ENST00000251076.5	-	25	6913	c.6626C>T	c.(6625-6627)tCa>tTa	p.S2209L	DMXL2_ENST00000543779.2_Missense_Mutation_p.S2209L|RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.S1573L	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2209						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		AATACTTGCTGAAAGCAGAGG	0.363000													38	135					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15647732	15647732	+	Missense_Mutation	SNP	G	G	A	rs150148399		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr10:15647732G>A	ENST00000378076.3	-	19	2314	c.1961C>T	c.(1960-1962)tCg>tTg	p.S654L		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	654					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGGTCTAGCCGACAGCTTCAA	0.388000													12	60					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41918852	41918852	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr22:41918852C>T	ENST00000396512.3	+	10	1249	c.1232C>T	c.(1231-1233)aCc>aTc	p.T411I	ACO2_ENST00000216254.4_Missense_Mutation_p.T386I			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	386					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						GGTAGCTGCACCAATTCAAGC	0.542000													7	48					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167753961	167753961	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:167753961C>T	ENST00000239587.5	+	3	661	c.573C>T	c.(571-573)ttC>ttT	p.F191F		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	191	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATACCAAGTTCGTGGCTGAAT	0.498000													22	89					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155922435	155922435	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:155922435C>G	ENST00000368316.1	-	19	2354	c.1884G>C	c.(1882-1884)caG>caC	p.Q628H	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.Q656H|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.Q655H|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.Q657H|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.Q628H			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	656					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGATGGCATCCTGCAGCAGCC	0.617000													7	38					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598406	68598406	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:68598406G>C	ENST00000570495.1	+	5	2008	c.1716G>C	c.(1714-1716)gaG>gaC	p.E572D	ZFP90_ENST00000563169.2_Missense_Mutation_p.E572D|RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.E572D			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	572					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TTCAGCATGAGAGAACTCATA	0.428000													6	248					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520540	33520540	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:33520540C>T	ENST00000297307.5	-	1	872	c.787G>A	c.(787-789)Gcc>Acc	p.A263T		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	263						integral to membrane		p.A263T(1)									GAGACCAAGGCGAGGATCCCC	0.627000													5	130					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75298484	75298484	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr11:75298484G>T	ENST00000304771.3	-	4	2812	c.2062C>A	c.(2062-2064)Cca>Aca	p.P688T	MAP6_ENST00000526740.1_Missense_Mutation_p.P359T|CTD-2530H12.4_ENST00000527803.1_RNA	NM_033063.1	NP_149052.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	688	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					GCATGCTCTGGGACTACAACA	0.493000													26	332					2.79863e-10	3.02866e-10	1	1	0
GMDS	2762	broad.mit.edu	37	6	1726714	1726714	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:1726714C>T	ENST00000380815.4	-	9	1192	c.923G>A	c.(922-924)aGa>aAa	p.R308K	GMDS_ENST00000530927.1_Missense_Mutation_p.R278K	NM_001500.3	NP_001491.1	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	308					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity		GMDS/PDE8B(2)	breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|prostate(1)	21	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTCTTTACATCTGCCCACTTC	0.488000													12	122					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113975980	113975980	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr13:113975980C>T	ENST00000332556.4	+	8	1246	c.1052C>T	c.(1051-1053)tCa>tTa	p.S351L	LAMP1_ENST00000397181.3_Missense_Mutation_p.S298L	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	351	Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AAGGCGTTTTCAGTCAATATA	0.577000													23	117					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627131	29627131	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:29627131C>T	ENST00000376894.4	+	2	242	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	MOG_ENST00000396701.2_Missense_Mutation_p.R42W|MOG_ENST00000376891.4_Missense_Mutation_p.R42W|MOG_ENST00000431798.2_Missense_Mutation_p.R42W|MOG_ENST00000376902.3_Missense_Mutation_p.R42W|MOG_ENST00000416766.2_Missense_Mutation_p.R42W|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000396704.3_Missense_Mutation_p.R42W|MOG_ENST00000483013.1_Intron|MOG_ENST00000376888.2_Intron|MOG_ENST00000490427.1_Intron|MOG_ENST00000376898.3_Missense_Mutation_p.R42W|MOG_ENST00000376917.3_Missense_Mutation_p.R42W|MOG_ENST00000533330.2_Missense_Mutation_p.R42W|MOG_ENST00000494692.1_Missense_Mutation_p.R42W			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	42	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						ACACCCTATCCGGGCTCTGGT	0.547000													44	252					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703978	113703978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr9:113703978C>T	ENST00000374431.3	-	4	899	c.516G>A	c.(514-516)tgG>tgA	p.W172*	LPAR1_ENST00000538760.1_Nonsense_Mutation_p.W173*|LPAR1_ENST00000358883.4_Nonsense_Mutation_p.W172*|LPAR1_ENST00000374430.2_Nonsense_Mutation_p.W172*|LPAR1_ENST00000541779.1_Nonsense_Mutation_p.W173*	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	172					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						TGGCCATAGTCCAGATGACCA	0.502000													23	73					0	0	1	0	0
ARL4C	10123	broad.mit.edu	37	2	235404810	235404810	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr2:235404810C>T	ENST00000390645.2	-	1	887	c.421G>A	c.(421-423)Gag>Aag	p.E141K	ARL4C_ENST00000339728.3_Missense_Mutation_p.E141K	NM_005737.3	NP_005728.2	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	141					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			endometrium(1)|ovary(1)|skin(1)|urinary_tract(1)	4		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		AGCTGCTTCTCAATCTCTGCC	0.647000													11	45					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321708	78321708	+	Silent	SNP	C	C	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:78321708C>A	ENST00000582970.1	+	29	9716	c.9573C>A	c.(9571-9573)ctC>ctA	p.L3191L	RNF213_ENST00000508628.2_Silent_p.L3240L|RNF213_ENST00000336301.6_Silent_p.L1264L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGGAGGAGCTCTGTGCGTGGG	0.512000													8	35					0.000157383	0.000161471	1	1	0
NUCKS1	64710	broad.mit.edu	37	1	205687518	205687518	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:205687518C>T	ENST00000367142.4	-	7	924	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K		NM_022731.4	NP_073568.2	Q9H1E3	NUCKS_HUMAN	nuclear casein kinase and cyclin-dependent kinase substrate 1	208						nucleus				endometrium(4)|large_intestine(1)|lung(9)	14	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TCCTCATCTTCTTCTTTGGGA	0.507000													33	244					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329557	7329557	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr17:7329557C>G	ENST00000333870.3	+	3	321	c.247C>G	c.(247-249)Cag>Gag	p.Q83E	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	83						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				AGACAAGGCTCAGGATGTCCA	0.542000													24	90					0	0	1	0	0
B3GAT2	135152	broad.mit.edu	37	6	71603971	71603971	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:71603971C>T	ENST00000230053.6	-	2	1204	c.596G>A	c.(595-597)cGa>cAa	p.R199Q		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	199					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						GCGGGTGGTTCGCATCTATAA	0.507000													6	50					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84906615	84906615	+	Silent	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:84906615C>T	ENST00000262424.5	+	10	1223	c.999C>T	c.(997-999)cgC>cgT	p.R333R	CRISPLD2_ENST00000564567.1_Silent_p.R333R|CRISPLD2_ENST00000567845.1_Silent_p.R332R	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	333	LCCL 1.					extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						GCATATGCCGCGCCGCCATCC	0.552000													62	132					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41808584	41808584	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr19:41808584C>T	ENST00000392006.3	+	12	1875	c.1702C>T	c.(1702-1704)Cca>Tca	p.P568S	HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.P568S|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.P468S|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.P468S|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.P468S|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.P454S|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.P479S	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	568	Necessary for interaction with BRD7 and transcriptional activation.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CTTCACGTTGCCAGATGTTGG	0.552000													14	76					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21799304	21799304	+	Silent	SNP	G	G	A			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr22:21799304G>A	ENST00000443632.2	+	2	492	c.120G>A	c.(118-120)agG>agA	p.R40R	HIC2_ENST00000407464.2_Silent_p.R40R|HIC2_ENST00000407598.2_Silent_p.R40R			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	40					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				ACCAGCAGAGGACCAAGGGCT	0.627000													42	95					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415945	86415945	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr7:86415945C>G	ENST00000361669.2	+	3	1936	c.837C>G	c.(835-837)gaC>gaG	p.D279E	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.D277E|GRM3_ENST00000536043.1_Missense_Mutation_p.D151E|GRM3_ENST00000439827.1_Missense_Mutation_p.D279E|AC005009.2_ENST00000418031.1_RNA	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	279					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCGCAGCGACGACTCGCGGG	0.657000													7	70					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21745068	21745068	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr18:21745068C>T	ENST00000319481.3	-	27	2917	c.2711G>A	c.(2710-2712)cGc>cAc	p.R904H	OSBPL1A_ENST00000399443.3_Missense_Mutation_p.R391H|OSBPL1A_ENST00000357041.4_Missense_Mutation_p.R522H	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	904					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CCTGTTTTTGCGGGCTGCTCT	0.488000													5	281					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90399691	90399691	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr6:90399691G>C	ENST00000369393.3	-	65	11036	c.10921C>G	c.(10921-10923)Caa>Gaa	p.Q3641E	MDN1_ENST00000428876.1_Missense_Mutation_p.Q3641E			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3641					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGAGTCTGTTGATACCAGAGG	0.502000													21	89					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161167833	161167833	+	Silent	SNP	G	G	A	rs114749477	by1000genomes	TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:161167833G>A	ENST00000367996.4	-	1	1013	c.585C>T	c.(583-585)aaC>aaT	p.N195N	ADAMTS4_ENST00000367995.3_Silent_p.N195N	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	195					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GAGCCTTGACGTTGCACATGG	0.642000													12	61					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325653	47325654	+	RNA	INS	-	-	T			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:47325653_47325654insT	ENST00000505841.1	-	0	1070					NR_002788.2																						TAACTGTAAGCTTTTTTTTCGC	0.371													2	4	---	---	---	---					
SEC22B	9554	broad.mit.edu	37	1	145109312	145109313	+	RNA	INS	-	-	A	rs148903206		TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr1:145109312_145109313insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										aaaccaaaaacaaaAAAAAAAG	0.416													3	5	---	---	---	---					
NPIPB15	440348	broad.mit.edu	37	16	74425400	74425402	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr16:74425400_74425402delCAA	ENST00000429990.1	+	7	850_852	c.754_756delCAA	c.(754-756)del	p.Q253del						nuclear pore complex interacting protein family, member B15																		TCCTCCAACTCAACAACATTCTA	0.517													7	286	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-P3-A6T3-01A-11D-A34J-08	TCGA-P3-A6T3-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f755746c-c1e7-4b10-8cc4-2468ae3f5872	fcaf5dd9-c2dc-43cf-8f74-cf9f7d7085b6	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													2	4	---	---	---	---