Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC35D2	11046	broad.mit.edu	37	9	99126820	99126820	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr9:99126820T>C	ENST00000253270.7	-	3	267	c.205A>G	c.(205-207)Ata>Gta	p.I69V	SLC35D2_ENST00000375257.1_Missense_Mutation_p.I69V|SLC35D2_ENST00000482643.1_5'UTR|SLC35D2_ENST00000375259.4_Missense_Mutation_p.I69V	NM_007001.2	NP_008932.2	Q76EJ3	S35D2_HUMAN	solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2	69						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity			endometrium(3)|large_intestine(3)|lung(4)|skin(2)	12		Acute lymphoblastic leukemia(62;0.0167)				AGTATCATTATGGTGGCTGCC	0.343000													15	63					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13653622	13653622	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr10:13653622G>C	ENST00000378572.3	+	6	678	c.518G>C	c.(517-519)gGa>gCa	p.G173A		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	173					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						CAGGCGCTTGGAGAGTCCTTA	0.433000													12	41					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241608	60241608	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr18:60241608C>A	ENST00000269499.5	+	13	2712	c.2294C>A	c.(2293-2295)gCa>gAa	p.A765E	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.A444E	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	765					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AGGGAGTCTGCAAATTCAACC	0.478000													4	34					2.56e-06	2.8703e-06	1	1	0
IGHV1-58	28464	broad.mit.edu	37	14	107078514	107078514	+	RNA	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr14:107078514G>A	ENST00000390628.2	-	0	270																											TGCCAACGACGATCCATCCTA	0.522000													7	113					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182027001	182027001	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:182027001C>T	ENST00000339948.3	-	2	352	c.145G>A	c.(145-147)Gct>Act	p.A49T		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						ACCGGGTCAGCGGTGCCCTCT	0.552000													19	61					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	2188861	2188861	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr7:2188861G>A	ENST00000406869.1	-	11	1556	c.999C>T	c.(997-999)gaC>gaT	p.D333D	MAD1L1_ENST00000399654.2_Silent_p.D333D|MAD1L1_ENST00000402746.1_Silent_p.D241D|MAD1L1_ENST00000265854.7_Silent_p.D333D			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	333					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		ATCTGGAAAGGTCTTCTGGAG	0.547000													6	28					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93104354	93104354	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr11:93104354G>C	ENST00000298050.3	+	7	797	c.697G>C	c.(697-699)Gct>Cct	p.A233P		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	233										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				ACTGAAATCAGCTGTAAATGA	0.368000													7	16					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	AC004943.1_ENST00000584072.1_RNA|ZFHX3_ENST00000397992.5_Silent_p.G2606G	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													4	34					0	0	1	0	0
IDH3A	3419	broad.mit.edu	37	15	78454590	78454590	+	Silent	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr15:78454590C>T	ENST00000299518.2	+	6	575	c.492C>T	c.(490-492)gtC>gtT	p.V164V	IDH3A_ENST00000441490.2_Silent_p.V55V|IDH3A_ENST00000558535.1_3'UTR|IDH3A_ENST00000559205.1_Intron|IDH3A_ENST00000558554.1_Silent_p.V129V	NM_005530.2	NP_005521.1	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha	164					carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding			endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	12					NADH(DB00157)	TTGATGGAGTCGTGCAGAGTA	0.552000													10	50					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2160311	2160311	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr16:2160311G>A	ENST00000262304.4	-	15	5065	c.4857C>T	c.(4855-4857)tcC>tcT	p.S1619S	PKD1_ENST00000423118.1_Silent_p.S1619S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1619	PKD 11.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TGTCCTGGGCGGAGCCCACCT	0.622000													5	85					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41483692	41483692	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:41483692C>T	ENST00000359345.1	-	2	3148	c.572G>A	c.(571-573)cGg>cAg	p.R191Q	SLFNL1_ENST00000439569.2_Missense_Mutation_p.R191Q|SLFNL1_ENST00000302946.8_Missense_Mutation_p.R191Q|SLFNL1_ENST00000372611.1_Intron|SLFNL1_ENST00000372613.2_Missense_Mutation_p.R191Q|SLFNL1_ENST00000397197.2_Missense_Mutation_p.R191Q	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	191							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GCCGCTGGGCCGGCCCTGGCA	0.682000													5	12					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111493993	111493993	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:111493993G>C	ENST00000369763.4	-	2	1903	c.1513C>G	c.(1513-1515)Cag>Gag	p.Q505E	RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron|LRIF1_ENST00000485275.2_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						TCTATGCTCTGGAGGACACTT	0.393000													6	134					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2973895	2973895	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr12:2973895C>A	ENST00000342628.2	-	7	1157	c.1044G>T	c.(1042-1044)gaG>gaT	p.E348D	FOXM1_ENST00000361953.3_Missense_Mutation_p.E333D|FOXM1_ENST00000359843.3_Missense_Mutation_p.E348D	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	348					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TCCGGCGGAGCTCTGGATTCG	0.537000													11	140					0.00136819	0.00148892	1	1	0
KCNJ3	3760	broad.mit.edu	37	2	155711734	155711734	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:155711734C>A	ENST00000295101.2	+	3	1892	c.1415C>A	c.(1414-1416)cCa>cAa	p.P472Q		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	472					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	GATTTGCCACCAAAGCTTCAA	0.443000													3	29					1	1	1	1	0
SHC3	53358	broad.mit.edu	37	9	91657078	91657078	+	Missense_Mutation	SNP	G	G	A	rs112676570	byFrequency	TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr9:91657078G>A	ENST00000375835.4	-	10	1529	c.1223C>T	c.(1222-1224)aCg>aTg	p.T408M	SHC3_ENST00000375830.1_De_novo_Start_InFrame	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	408	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						CCCTTCTGGCGTGCTGTAGAT	0.567000													6	119					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123515050	123515050	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chrX:123515050C>T	ENST00000422452.2	-	32	7598	c.7535G>A	c.(7534-7536)cGg>cAg	p.R2512Q	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.R2505Q	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTCAAGGCACCGTCCATCATT	0.458000													39	43					0	0	1	0	0
MINPP1	9562	broad.mit.edu	37	10	89265179	89265179	+	Silent	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr10:89265179C>T	ENST00000371996.4	+	1	548	c.507C>T	c.(505-507)ttC>ttT	p.F169F	MINPP1_ENST00000371994.4_Silent_p.F169F	NM_004897.4	NP_004888.2	Q9UNW1	MINP1_HUMAN	multiple inositol-polyphosphate phosphatase 1	169					bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|urinary_tract(2)	5		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		CGGCCCTTTTCAGCCGTGAGA	0.642000											OREG0020348	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	44					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650297	55650297	+	Silent	SNP	C	C	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chrX:55650297C>A	ENST00000339140.3	+	1	465	c.153C>A	c.(151-153)gtC>gtA	p.V51V		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	51					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						AATACAGAGTCGGAGTAATGA	0.527000													23	38					2.27525e-19	2.59029e-19	1	1	0
PIK3CD	5293	broad.mit.edu	37	1	9775731	9775731	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:9775731G>A	ENST00000536656.1	+	4	482	c.274G>A	c.(274-276)Gtg>Atg	p.V92M	PIK3CD_ENST00000377346.4_Missense_Mutation_p.V92M|PIK3CD_ENST00000361110.2_Missense_Mutation_p.V92M			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	92					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGTGTGACGTGCAGCCCTT	0.617000													13	56					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807495	22807495	+	Silent	SNP	G	G	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr18:22807495G>T	ENST00000361524.3	-	4	535	c.387C>A	c.(385-387)cgC>cgA	p.R129R	ZNF521_ENST00000584787.1_5'UTR|ZNF521_ENST00000538137.2_Silent_p.R129R	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	129					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGTAGCTGAGGCGGCTAAACG	0.517000			T	PAX5	ALL								5	128					0.184627	0.189756	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21217225	21217225	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr9:21217225G>T	ENST00000380216.1	-	1	85	c.80C>A	c.(79-81)cCt>cAt	p.P27H		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	27					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GTGAGTCTGAGGCAGATCACA	0.488000													4	125					0.00909568	0.00948	1	1	0
GHRHR	2692	broad.mit.edu	37	7	31014608	31014608	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr7:31014608T>C	ENST00000409904.3	+	6	901	c.643T>C	c.(643-645)Tcc>Ccc	p.S215P	GHRHR_ENST00000409316.1_Missense_Mutation_p.L45P|GHRHR_ENST00000326139.2_Missense_Mutation_p.S279P|GHRHR_ENST00000461424.1_3'UTR			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	279					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	GGACGACACCTCCCCCTACTG	0.582000											OREG0017943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	109					0	0	1	0	0
GGT6	124975	broad.mit.edu	37	17	4462969	4462969	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:4462969C>G	ENST00000301395.3	-	2	286	c.227G>C	c.(226-228)aGg>aCg	p.R76T	GGT6_ENST00000381550.3_Missense_Mutation_p.R76T|GGT6_ENST00000574154.1_Missense_Mutation_p.R76T|GGT6_ENST00000573591.1_5'UTR	NM_153338.2	NP_699169.2	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6	76					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						CTGGAGCTGCCTCACAGCCAG	0.692000													11	54					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12277092	12277092	+	Nonsense_Mutation	SNP	C	C	T	rs139964730		TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr10:12277092C>T	ENST00000281141.4	+	8	815	c.535C>T	c.(535-537)Cga>Tga	p.R179*	CDC123_ENST00000455773.3_3'UTR|CDC123_ENST00000378900.2_Nonsense_Mutation_p.R179*	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	179					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						GGCTGAGTTTCGATGTTTTGT	0.333000													22	66					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58579419	58579419	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:58579419G>T	ENST00000506786.1	+	5	1995	c.1441G>T	c.(1441-1443)Gaa>Taa	p.E481*	ZNF135_ENST00000439855.2_Nonsense_Mutation_p.E523*|ZNF135_ENST00000401053.4_Nonsense_Mutation_p.E547*|ZNF135_ENST00000313434.5_Nonsense_Mutation_p.E523*|ZNF135_ENST00000359978.6_Intron|ZNF135_ENST00000511556.1_Nonsense_Mutation_p.E535*			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	535					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GAAGCCCTACGAATGCAACCA	0.537000													23	71					2.70639e-06	2.98915e-06	1	1	0
BRD4	23476	broad.mit.edu	37	19	15355538	15355538	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:15355538C>T	ENST00000263377.2	-	12	2415	c.2194G>A	c.(2194-2196)Ggg>Agg	p.G732R		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	732					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TGCTCCCTCCCGGGGTGCCCC	0.582000			T	C15orf55	lethal midline carcinoma of young people								12	193					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39802098	39802098	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:39802098T>C	ENST00000564288.1	+	37	10615	c.9838T>C	c.(9838-9840)Tct>Cct	p.S3280P	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.S3317P|MACF1_ENST00000289893.4_Missense_Mutation_p.S1720P|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.S3285P|MACF1_ENST00000361689.2_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3285					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAAGGAGTGTCTCAAAAAGA	0.448000													36	95					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124421612	124421612	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr12:124421612G>A	ENST00000545135.1	-	3	4234	c.938C>T	c.(937-939)aCt>aTt	p.T313I	CCDC92_ENST00000238156.3_Missense_Mutation_p.T330I|CCDC92_ENST00000545891.1_Missense_Mutation_p.T313I|CCDC92_ENST00000544798.1_Intron			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	330										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		GCTTCACACAGTTCTGTCCGT	0.632000													16	62					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186645077	186645077	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:186645077C>A	ENST00000367468.5	-	8	1346	c.1210G>T	c.(1210-1212)Gga>Tga	p.G404*	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	404					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	TGGGTAATTCCATGTTCCAGC	0.373000													4	66					0.00909568	0.00948	1	1	0
CLUH	23277	broad.mit.edu	37	17	2601293	2601293	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:2601293C>T	ENST00000570628.1	-	10	1849	c.1744G>A	c.(1744-1746)Gag>Aag	p.E582K	CLUH_ENST00000538975.1_Missense_Mutation_p.E582K|CLUH_ENST00000575014.1_Missense_Mutation_p.E514K|CLUH_ENST00000435359.1_Missense_Mutation_p.E582K					clustered mitochondria (cluA/CLU1) homolog																		GGCAGCTCCTCGCCAGGCACG	0.692000													3	7					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27695886	27695886	+	Silent	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:27695886C>G	ENST00000270879.4	-	8	746	c.741G>C	c.(739-741)gtG>gtC	p.V247V	FCN3_ENST00000354982.2_Silent_p.V236V	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	247	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGTGGACAATCACTGCACAGT	0.542000													16	69					0	0	1	0	0
MOK	5891	broad.mit.edu	37	14	102698092	102698092	+	Silent	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr14:102698092C>T	ENST00000361847.2	-	10	1164	c.933G>A	c.(931-933)ccG>ccA	p.P311P	MOK_ENST00000520266.1_Intron|MOK_ENST00000193029.6_Intron|MOK_ENST00000524214.1_Silent_p.P281P|MOK_ENST00000523231.1_Intron|MOK_ENST00000522867.1_Intron|MOK_ENST00000522534.1_Intron|MOK_ENST00000522874.1_Silent_p.P310P|MOK_ENST00000561150.1_Intron|MOK_ENST00000524370.1_Intron|MOK_ENST00000519058.1_Intron|MOK_ENST00000517966.1_Intron	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	311					signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										TGAGTGGTTCCGGTGCCACAG	0.577000													10	201					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176833488	176833488	+	Silent	SNP	T	T	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:176833488T>G	ENST00000367654.2	-	23	3854	c.3841A>C	c.(3841-3843)Agg>Cgg	p.R1281R	ASTN1_ENST00000367657.3_Intron|ASTN1_ENST00000361833.2_Silent_p.R1273R			O14525	ASTN1_HUMAN	astrotactin 1	1281					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CACGTCTTCCTGAGGTCCCGG	0.577000													5	108					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42801322	42801322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr5:42801322G>A	ENST00000514985.1	-	5	902	c.646C>T	c.(646-648)Cag>Tag	p.Q216*	SEPP1_ENST00000509276.1_5'UTR|CCDC152_ENST00000361970.5_3'UTR|SEPP1_ENST00000507920.1_Silent_p.I105I|SEPP1_ENST00000511224.1_Nonsense_Mutation_p.Q216*|SEPP1_ENST00000506577.1_Nonsense_Mutation_p.Q216*	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	216					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						CCAAGGTGCTGATGTCCATGA	0.463000													20	74					0	0	1	0	0
SEC22A	26984	broad.mit.edu	37	3	122928127	122928127	+	Silent	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr3:122928127T>C	ENST00000309934.4	+	1	959	c.63T>C	c.(61-63)tcT>tcC	p.S21S	SEC22A_ENST00000477063.1_3'UTR|SEC22A_ENST00000492595.1_Silent_p.S21S|SEC22A_ENST00000481965.2_Silent_p.S21S	NM_012430.4	NP_036562.2	Q96IW7	SC22A_HUMAN	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	21	Longin.				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			NS(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	10				GBM - Glioblastoma multiforme(114;0.0548)		TTTCTGCTTCTACTGATTATG	0.378000													3	75					0	0	1	0	0
HAND1	9421	broad.mit.edu	37	5	153855462	153855462	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr5:153855462G>A	ENST00000231121.2	-	2	807	c.552C>T	c.(550-552)caC>caT	p.H184H		NM_004821.2	NP_004812.1	O96004	HAND1_HUMAN	heart and neural crest derivatives expressed 1	184					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GAAAACCTTCGTGCTGCTGCT	0.572000													6	54					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61180204	61180204	+	Silent	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:61180204C>T	ENST00000316752.6	-	15	1497	c.1236G>A	c.(1234-1236)aaG>aaA	p.K412K	PUS10_ENST00000407787.1_Silent_p.K412K	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	412					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			CACTGTAGGTCTTTGTCTTTT	0.299000													15	123					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23871948	23871948	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr14:23871948G>A	ENST00000405093.3	-	11	1030	c.960C>T	c.(958-960)tcC>tcT	p.S320S	MYH6_ENST00000356287.3_Silent_p.S320S	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	320	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGGAGGCCACGGACACCTCTC	0.652000													14	43					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002469	69002469	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:69002469G>A	ENST00000295381.3	+	2	597	c.178G>A	c.(178-180)Gtg>Atg	p.V60M	ARHGAP25_ENST00000409220.1_Missense_Mutation_p.V53M|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.V60M|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.V53M|ARHGAP25_ENST00000544262.1_Missense_Mutation_p.V34M|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.V60M|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.V53M|ARHGAP25_ENST00000456116.2_3'UTR	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	60	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GAGGTCCATCGTGAAGAACTG	0.582000													6	205					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197559098	197559098	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr3:197559098C>T	ENST00000438796.2	+	8	1056	c.1012C>T	c.(1012-1014)Cga>Tga	p.R338*	LRCH3_ENST00000441090.2_Nonsense_Mutation_p.R212*|LRCH3_ENST00000425562.2_Nonsense_Mutation_p.R338*|LRCH3_ENST00000414675.2_Nonsense_Mutation_p.R338*|LRCH3_ENST00000334859.4_Nonsense_Mutation_p.R338*|LRCH3_ENST00000536618.1_5'UTR			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	338						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TCTGCCTCTTCGAGTAGCAGA	0.408000													4	76					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122928585	122928585	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr11:122928585C>G	ENST00000534624.1	-	9	2074	c.1798G>C	c.(1798-1800)Gag>Cag	p.E600Q	HSPA8_ENST00000526110.1_Missense_Mutation_p.E581Q|HSPA8_ENST00000534319.1_Missense_Mutation_p.E364Q|HSPA8_ENST00000533540.1_Missense_Mutation_p.E454Q|HSPA8_ENST00000532636.1_Missense_Mutation_p.E600Q|HSPA8_ENST00000453788.2_Intron|HSPA8_ENST00000227378.3_Missense_Mutation_p.E600Q	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	600					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CAAACTTTCTCCAGCTCTTTC	0.468000													4	101					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38427145	38427145	+	Silent	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr5:38427145T>C	ENST00000322350.5	+	14	2191	c.1845T>C	c.(1843-1845)tcT>tcC	p.S615S	EGFLAM_ENST00000336740.6_Silent_p.S381S|EGFLAM_ENST00000354891.3_Silent_p.S615S|EGFLAM-AS1_ENST00000508986.1_RNA|EGFLAM_ENST00000397202.2_5'UTR	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	615	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCAGAGAGTCTCTGAGATCTT	0.493000													4	121					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073002	15073002	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:15073002C>G	ENST00000598504.1	-	8	2106	c.747G>C	c.(745-747)gaG>gaC	p.E249D	SLC1A6_ENST00000430939.2_Missense_Mutation_p.E185D|SLC1A6_ENST00000544886.2_Missense_Mutation_p.E249D|SLC1A6_ENST00000600144.1_Missense_Mutation_p.E249D|SLC1A6_ENST00000221742.3_Missense_Mutation_p.E249D	NM_001272087.1	NP_001259016.1	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	249					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	AGCTCAGCATCTCCTGCAGGG	0.602000													4	90					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150498790	150498790	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr7:150498790G>T	ENST00000484928.1	+	2	733	c.152G>T	c.(151-153)aGc>aTc	p.S51I	TMEM176A_ENST00000004103.3_Missense_Mutation_p.S51I|TMEM176A_ENST00000461345.1_Intron			Q96HP8	T176A_HUMAN	transmembrane protein 176A	51						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGGCAGCAGCCGGCTGCTG	0.706000													4	11					1	1	1	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	55					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382599	22382599	+	Missense_Mutation	SNP	T	T	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr15:22382599T>G	ENST00000328795.4	+	1	218	c.127T>G	c.(127-129)Ttt>Gtt	p.F43V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCCTGGAAATTTTCTCATTAT	0.438000													5	101					0	0	1	0	0
EMC1	23065	broad.mit.edu	37	1	19547305	19547305	+	Silent	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:19547305C>T	ENST00000477853.1	-	21	2667	c.2625G>A	c.(2623-2625)aaG>aaA	p.K875K	EMC1_ENST00000375199.3_Silent_p.K874K|EMC1_ENST00000375208.3_Silent_p.K853K|EMC1_ENST00000480380.1_5'UTR|RP1-43E13.2_ENST00000437898.1_RNA	NM_001271428.1|NM_015047.1	NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1																		CCAGCAAAGCCTTAGGAAGGG	0.512000													11	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179571293	179571293	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:179571293G>A	ENST00000589042.1	-	102	29532	c.29308C>T	c.(29308-29310)Cga>Tga	p.R9770*	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Nonsense_Mutation_p.R8526*|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.R9453*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9453	Ig-like 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R8526R(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCACGCATCGGTATAACCCA	0.418000													7	111					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073336	67073336	+	Splice_Site	SNP	C	C	T			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr15:67073336C>T	ENST00000288840.5	+	4	1985	c.952_splice	c.e4-1	p.D318_splice	SMAD6_ENST00000338426.4_Splice_Site_p.D57_splice	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	318					BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						GTCCCGCAGACGCCAGCATGT	0.687000													4	6					0	0	1	0	0
NIPSNAP3B	55335	broad.mit.edu	37	9	107531143	107531143	+	Splice_Site	SNP	G	G	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr9:107531143G>C	ENST00000374762.3	+	3	342		c.e3-1		NIPSNAP3B_ENST00000461177.1_Splice_Site	NM_018376.2	NP_060846.2	Q9BS92	NPS3B_HUMAN	nipsnap homolog 3B (C. elegans)											breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	11						TCCTCCCATAGATAATTTTGC	0.358000													6	27					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151315105	151315105	+	Silent	SNP	G	G	T	rs79106593		TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr1:151315105G>T	ENST00000290524.4	-	11	1586	c.1408C>A	c.(1408-1410)Cga>Aga	p.R470R	RFX5_ENST00000452671.2_Silent_p.R470R|RFX5_ENST00000452513.2_Silent_p.R430R|RFX5_ENST00000368870.2_Silent_p.R470R	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	470						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GACTTTTTTCGAGGGCGCCCC	0.537000													92	332					6.7531e-64	7.80827e-64	1	1	0
CDC42EP4	23580	broad.mit.edu	37	17	71281908	71281908	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:71281908G>A	ENST00000335793.3	-	2	1126	c.732C>T	c.(730-732)ggC>ggT	p.G244G	CDC42EP4_ENST00000439510.2_Silent_p.G174G|CDC42EP4_ENST00000581014.1_Intron			Q9H3Q1	BORG4_HUMAN	CDC42 effector protein (Rho GTPase binding) 4	244					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(7)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TGCCAGCGGCGCCCTCATCGC	0.692000													3	43					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41577280	41577280	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr8:41577280G>A	ENST00000396942.1	-	10	1089	c.1006C>T	c.(1006-1008)Ctg>Ttg	p.L336L	ANK1_ENST00000396945.1_Silent_p.L336L|ANK1_ENST00000265709.8_Silent_p.L369L|ANK1_ENST00000289734.7_Silent_p.L336L|ANK1_ENST00000352337.4_Silent_p.L336L|ANK1_ENST00000347528.4_Silent_p.L336L|ANK1_ENST00000379758.2_Silent_p.L336L			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	336	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGGTGGTCCAGGGTGATGTCG	0.602000													12	192					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74068416	74068416	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:74068416C>G	ENST00000307877.2	-	1	318	c.157G>C	c.(157-159)Gaa>Caa	p.E53Q	SRP68_ENST00000539137.1_Missense_Mutation_p.E53Q|SRP68_ENST00000355113.5_Intron	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	53					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						TCCCCAAATTCTTTGTTTGCC	0.587000													6	568					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608996	101608996	+	Silent	SNP	T	T	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr8:101608996T>C	ENST00000311812.2	-	10	999	c.849A>G	c.(847-849)gaA>gaG	p.E283E	SNX31_ENST00000428383.2_Silent_p.E184E	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	283					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CAGAGCCTGATTCTGGGTAGT	0.542000													11	161					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79465561	79465561	+	Silent	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr9:79465561C>G	ENST00000376718.3	-	3	285	c.162G>C	c.(160-162)ctG>ctC	p.L54L	PRUNE2_ENST00000376713.3_Silent_p.L54L|PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	54					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTGGTAAACACAGAACCCCTG	0.393000													10	65					0	0	1	0	0
C19orf47	126526	broad.mit.edu	37	19	40827960	40827960	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:40827960C>G	ENST00000582783.1	-	9	1110	c.1098G>C	c.(1096-1098)caG>caC	p.Q366H	C19orf47_ENST00000584868.1_5'UTR|C19orf47_ENST00000392035.2_Missense_Mutation_p.Q299H	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	366										endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			CCTGGCTGTCCTGGGCCTCGG	0.617000													10	53					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	210993802	210993802	+	Nonsense_Mutation	SNP	T	T	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:210993802T>A	ENST00000281772.9	-	3	1446	c.1183A>T	c.(1183-1185)Aaa>Taa	p.K395*	KANSL1L_ENST00000452086.1_Nonsense_Mutation_p.K395*|KANSL1L_ENST00000457374.1_Nonsense_Mutation_p.K395*|KANSL1L_ENST00000418791.1_Nonsense_Mutation_p.K395*	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	395																	TGTTGGATTTTGCATTCTAGG	0.408000													4	92					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36596713	36596713	+	Missense_Mutation	SNP	A	A	G			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr11:36596713A>G	ENST00000299440.5	+	2	1971	c.1859A>G	c.(1858-1860)gAa>gGa	p.E620G		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	620					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GTAGTTCCAGAAAAGGCAGTC	0.453000									Familial Hemophagocytic Lymphohistiocytosis				11	27					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16996429	16996429	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr10:16996429G>C	ENST00000377833.4	-	32	4879	c.4814C>G	c.(4813-4815)cCt>cGt	p.P1605R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1605	CUB 10.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTGTCTGGAAGGGCCAGACTG	0.542000													29	144					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	63					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1615558	1615558	+	Silent	SNP	G	G	A			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:1615558G>A	ENST00000395423.3	-	14	1587	c.1560C>T	c.(1558-1560)caC>caT	p.H520H	TCF3_ENST00000453954.2_Intron|TCF3_ENST00000262965.5_Intron|TCF3_ENST00000588136.1_Intron|TCF3_ENST00000344749.5_Intron			P15923	TFE2_HUMAN	transcription factor 3	533					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGGAGACAGTGAGGTTGGG	0.697000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								10	32					0	0	1	0	0
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													3	6	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995077	146995077	+	RNA	DEL	A	A	-			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr3:146995077delA	ENST00000473299.1	-	0	132																											TCTGGACTGtaaaaaaaaaaa	0.294													5	8	---	---	---	---					
RP11-556I14.1	0	broad.mit.edu	37	4	105918247	105918247	+	RNA	DEL	T	T	-	rs140898060		TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr4:105918247delT	ENST00000506386.1	+	0	71																											ttttttttccttttttttttt	0.318													3	5	---	---	---	---					
PNPLA8	50640	broad.mit.edu	37	7	108154676	108154676	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr7:108154676delG	ENST00000426128.2	-	3	1243	c.1118delC	c.(1117-1119)aafs	p.T374fs	PNPLA8_ENST00000422087.1_Frame_Shift_Del_p.T374fs|PNPLA8_ENST00000257694.8_Frame_Shift_Del_p.T374fs|PNPLA8_ENST00000453144.1_Frame_Shift_Del_p.T274fs|PNPLA8_ENST00000483879.1_Intron|PNPLA8_ENST00000436062.1_Frame_Shift_Del_p.T374fs|PNPLA8_ENST00000388728.5_Frame_Shift_Del_p.T374fs	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	374					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						TGGGTCAGTTGTTCTTCTTAA	0.368													77	278	---	---	---	---					
GAS2L2	246176	broad.mit.edu	37	17	34071994	34071996	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr17:34071994_34071996delTCC	ENST00000254466.6	-	6	2547_2549	c.2520_2522delGGA	c.(2518-2523)gaa>ga	p.EE840del	GAS2L2_ENST00000587565.1_In_Frame_Del_p.EE824del	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	840					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ctcctttccttcctcctcctcct	0.616													8	86	---	---	---	---					
ZNF155	7711	broad.mit.edu	37	19	44500969	44500977	+	In_Frame_Del	DEL	ATGTGATAA	ATGTGATAA	-			TCGA-MZ-A6I9-01A-11D-A31L-08	TCGA-MZ-A6I9-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9b2f860-d5cb-4cca-884e-3116ade975e9	55a32649-2438-4b3c-bd15-1deebb5b9f7b	g.chr19:44500969_44500977delATGTGATAA	ENST00000270014.2	+	5	1088_1096	c.960_968delATGTGATAA	c.(958-969)acg>ac	p.TCDK320del	ZNF155_ENST00000407951.2_In_Frame_Del_p.TCDK331del|ZNF155_ENST00000590615.1_In_Frame_Del_p.TCDK320del	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	320						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				GGTGTGATACATGTGATAAGAGCTTTCAT	0.407													18	102	---	---	---	---