Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDUFV1	4723	broad.mit.edu	37	11	67379397	67379397	+	Silent	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:67379397C>A	ENST00000322776.6	+	8	1263	c.1110C>A	c.(1108-1110)ctC>ctA	p.L370L	NDUFV1_ENST00000415352.2_Silent_p.L363L|NDUFV1_ENST00000532303.1_Silent_p.L269L|NDUFV1_ENST00000526169.1_3'UTR|NDUFV1_ENST00000529927.1_Silent_p.L361L	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	370					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	TCGCCCGCCTCATTGAGTTCT	0.602000													25	43					4.87955e-14	5.34874e-14	1	1	0
ITGB4	3691	broad.mit.edu	37	17	73752598	73752598	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:73752598C>T	ENST00000200181.3	+	36	4984	c.4797C>T	c.(4795-4797)cgC>cgT	p.R1599R	ITGB4_ENST00000579662.1_Silent_p.R1529R|ITGB4_ENST00000450894.3_Silent_p.R1529R|GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000449880.2_Silent_p.R1582R|ITGB4_ENST00000339591.3_Silent_p.R1582R	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1599	Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGTGTTCCGCGTGCGGGCCC	0.652000													52	98					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746387	57746387	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:57746387G>C	ENST00000302804.7	+	6	906	c.720G>C	c.(718-720)gaG>gaC	p.E240D	AURKC_ENST00000448930.1_Missense_Mutation_p.E206D|AURKC_ENST00000415300.2_Missense_Mutation_p.E221D|AURKC_ENST00000598785.1_Missense_Mutation_p.E206D|AURKC_ENST00000599062.1_Missense_Mutation_p.E237D	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	240	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CACCCTTTGAGAGCGCCTCCC	0.537000													10	45					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68153966	68153966	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:68153966G>A	ENST00000294304.7	+	6	1304	c.1198G>A	c.(1198-1200)Gcg>Acg	p.A400T		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	400	Beta-propeller 2.		A -> E (in OPPG).		adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CATCCGCAGGGCGTACCTGGA	0.642000													33	58					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53573428	53573428	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:53573428C>T	ENST00000601421.1	-	3	1127	c.251G>A	c.(250-252)aGa>aAa	p.R84K	ZNF160_ENST00000599056.1_Missense_Mutation_p.R120K|ZNF160_ENST00000429604.1_Missense_Mutation_p.R120K|ZNF160_ENST00000418871.1_Missense_Mutation_p.R120K			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	120					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		GCTTTCGTGTCTTTCCAACAC	0.398000													37	49					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28608269	28608269	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:28608269C>G	ENST00000220562.4	+	7	3548	c.2646C>G	c.(2644-2646)ttC>ttG	p.F882L	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Missense_Mutation_p.F498L	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	882						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GCATCAACTTCTTCGTGAAGG	0.567000													50	73					0	0	1	0	0
MRPS17P9	359760	broad.mit.edu	37	X	118513990	118513990	+	RNA	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:118513990C>T	ENST00000413240.1	-	0	491																											AACTACCTATCTGGAGAGTCC	0.423000													21	29					0	0	1	0	0
NPTX2	4885	broad.mit.edu	37	7	98256518	98256518	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:98256518C>A	ENST00000265634.3	+	4	1095	c.930C>A	c.(928-930)caC>caA	p.H310Q		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	310	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GCAAGTGGCACCACATCTGTG	0.642000													22	42					4.16121e-05	4.27368e-05	1	1	0
SYCP2	10388	broad.mit.edu	37	20	58470571	58470571	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:58470571G>A	ENST00000357552.3	-	20	1811	c.1586C>T	c.(1585-1587)tCa>tTa	p.S529L	SYCP2_ENST00000371001.2_Missense_Mutation_p.S529L			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	529					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCTATTTTCTGATGTTTGAGA	0.373000													43	59					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51294809	51294809	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr15:51294809C>T	ENST00000261842.5	+	21	3470	c.3364C>T	c.(3364-3366)Ctt>Ttt	p.L1122F	AP4E1_ENST00000561397.1_3'UTR|AP4E1_ENST00000560508.1_Missense_Mutation_p.L1047F	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	1122					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CTGTTCTACTCTTCCTGACTA	0.458000													21	30					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287714	202287714	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:202287714C>T	ENST00000367278.3	+	18	2372	c.2283C>T	c.(2281-2283)ggC>ggT	p.G761G	LGR6_ENST00000255432.7_Silent_p.G709G|LGR6_ENST00000439764.2_Silent_p.G622G	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	761						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TGCCGCGGGGCGACTTTGAGG	0.622000													20	37					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23574161	23574161	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:23574161C>T	ENST00000396703.1	+	5	657	c.477C>T	c.(475-477)tcC>tcT	p.S159S	UBE2E2_ENST00000425792.1_Silent_p.S159S	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	159					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						TTCTCCTCTCCATCTGCTCAC	0.388000													28	44					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584883	82584883	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:82584883C>G	ENST00000423517.2	-	5	5723	c.5386G>C	c.(5386-5388)Gaa>Caa	p.E1796Q	PCLO_ENST00000333891.8_Missense_Mutation_p.E1796Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1727					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGTTGCTGTTCTATTTCCCTC	0.383000													29	69					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	40					0	0	1	0	0
ZNF235	9310	broad.mit.edu	37	19	44792495	44792495	+	Missense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:44792495G>T	ENST00000291182.4	-	5	1195	c.1093C>A	c.(1093-1095)Cat>Aat	p.H365N	ZNF235_ENST00000589799.1_Intron|ZNF235_ENST00000589248.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				ATAGGCAAATGAGCATAAAGA	0.453000													11	33					3.86212e-05	4.00256e-05	1	1	0
C1orf109	54955	broad.mit.edu	37	1	38155466	38155466	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:38155466C>T	ENST00000358011.4	-	2	276	c.87G>A	c.(85-87)caG>caA	p.Q29Q	C1orf109_ENST00000494120.1_5'UTR	NM_017850.1	NP_060320.1	Q9NX04	CA109_HUMAN	chromosome 1 open reading frame 109	29										lung(2)|prostate(2)	4		Myeloproliferative disorder(586;0.0393)				GCAGGGCACTCTGCCACAGGC	0.642000													22	25					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41285102	41285102	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:41285102C>G	ENST00000347132.5	+	5	874	c.792C>G	c.(790-792)aaC>aaG	p.N264K	KCNQ4_ENST00000509682.2_Missense_Mutation_p.N264K|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	264					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			AGGACGCCAACTCCGACTTCT	0.637000													45	63					0	0	1	0	0
CAPZA2	830	broad.mit.edu	37	7	116544411	116544411	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:116544411G>C	ENST00000361183.2	+	5	539	c.400G>C	c.(400-402)Gaa>Caa	p.E134Q	CAPZA2_ENST00000458284.2_Missense_Mutation_p.E134Q|CAPZA2_ENST00000490693.1_Missense_Mutation_p.E134Q	NM_006136.2	NP_006127.1	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line, alpha 2	134					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	13	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			TTACGTAAAAGAACATTACCC	0.408000													32	41					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33495263	33495263	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:33495263C>T	ENST00000268876.5	+	10	1432	c.1335C>T	c.(1333-1335)ctC>ctT	p.L445L	UNC45B_ENST00000591048.1_Silent_p.L445L|UNC45B_ENST00000433649.1_Silent_p.L445L|UNC45B_ENST00000394570.2_Silent_p.L445L|UNC45B_ENST00000378449.1_Silent_p.L445L	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	445					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TGGAGGCCCTCATCCATGCCT	0.557000													23	38					0	0	1	0	0
MIR1207	100302175	broad.mit.edu	37	8	129061434	129061434	+	RNA	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:129061434G>A	ENST00000408249.1	+	0	37					NR_031612.1																						GGCTGGCTGGGTCTGGTAGTG	0.567000													27	34					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37534656	37534656	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:37534656C>T	ENST00000299824.1	+	7	930	c.741C>T	c.(739-741)ctC>ctT	p.L247L	PPP1R16B_ENST00000373331.2_Intron	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	247					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				CAGCTGAGCTCCTCCTGGACC	0.597000													27	39					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69902832	69902832	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:69902832C>G	ENST00000358913.5	+	3	1526	c.1038C>G	c.(1036-1038)atC>atG	p.I346M	MYPN_ENST00000354393.2_Missense_Mutation_p.I71M|MYPN_ENST00000373675.3_Missense_Mutation_p.I346M|MYPN_ENST00000540630.1_Missense_Mutation_p.I346M	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	346	Ig-like 1.|Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CTTCTAACATCTATGGGACAG	0.393000													22	54					0	0	1	0	0
DPH3	285381	broad.mit.edu	37	3	16305733	16305733	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:16305733C>T	ENST00000488423.1	-	2	207	c.112G>A	c.(112-114)Gat>Aat	p.D38N	DPH3_ENST00000285082.4_5'UTR|DPH3_ENST00000383775.4_Intron	NM_206831.2	NP_996662.1	Q96FX2	DPH3_HUMAN	diphthamide biosynthesis 3	38					negative regulation of protein secretion|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of binding	cytoplasm|nucleus	metal ion binding|protein binding			large_intestine(2)	2						TTCTCCAAATCTTCCTACAAC	0.448000													12	15					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50811826	50811826	+	Nonsense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:50811826C>A	ENST00000540145.1	+	8	1527	c.1112C>A	c.(1111-1113)tCa>tAa	p.S371*	CYLD_ENST00000568704.2_Nonsense_Mutation_p.S368*|CYLD_ENST00000566206.1_Nonsense_Mutation_p.S368*|CYLD_ENST00000569418.1_Nonsense_Mutation_p.S368*|CYLD_ENST00000311559.9_Nonsense_Mutation_p.S371*|CYLD_ENST00000427738.3_Nonsense_Mutation_p.S371*|CYLD_ENST00000398568.2_Nonsense_Mutation_p.S368*|CYLD_ENST00000564326.1_Nonsense_Mutation_p.S368*			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	371	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.S371*(1)		central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				CAATCCAAATCAAAAAATACA	0.313000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				25	10					2.98393e-07	3.14971e-07	1	1	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													5	12					0.000602214	0.000612968	1	1	0
LONP1	9361	broad.mit.edu	37	19	5719865	5719865	+	Silent	SNP	T	T	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:5719865T>C	ENST00000360614.3	-	1	436	c.279A>G	c.(277-279)ggA>ggG	p.G93G	LONP1_ENST00000590511.1_5'UTR|LONP1_ENST00000593119.1_Intron|LONP1_ENST00000585374.1_Intron|LONP1_ENST00000540670.2_Intron	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	93					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						cgccgccggcTCCTTCCTCCG	0.736000													4	19					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49412473	49412473	+	Silent	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:49412473C>A	ENST00000299191.3	+	3	480	c.363C>A	c.(361-363)ggC>ggA	p.G121G		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	121										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						TGGTCCCTGGCAGCTACATCA	0.542000													4	3					0.184627	0.184627	1	1	0
MYH6	4624	broad.mit.edu	37	14	23862200	23862200	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:23862200C>T	ENST00000405093.3	-	24	3242	c.3172G>A	c.(3172-3174)Gag>Aag	p.E1058K	MYH6_ENST00000356287.3_Missense_Mutation_p.E1058K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1058					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGGTCGCCCTCCAGTTTCCGC	0.517000													37	88					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98563391	98563391	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:98563391G>A	ENST00000359863.4	+	48	7237	c.7028G>A	c.(7027-7029)cGg>cAg	p.R2343Q	TRRAP_ENST00000355540.3_Missense_Mutation_p.R2325Q|TRRAP_ENST00000446306.3_Missense_Mutation_p.R2325Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2343	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATGGAGATGCGGAAGAACTTC	0.527000													26	37					0	0	1	0	0
TRIM36	55521	broad.mit.edu	37	5	114472733	114472733	+	Missense_Mutation	SNP	T	T	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:114472733T>C	ENST00000513154.1	-	7	1500	c.1174A>G	c.(1174-1176)Aca>Gca	p.T392A	TRIM36_ENST00000514154.1_Missense_Mutation_p.T249A|TRIM36_ENST00000282369.3_Missense_Mutation_p.T404A			Q9NQ86	TRI36_HUMAN	tripartite motif containing 36	404	COS.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			breast(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	37		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AGAAGTTCTGTTTGTTTAGAG	0.353000													15	21					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160143991	160143991	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:160143991C>T	ENST00000368081.4	+	14	2553	c.2082C>T	c.(2080-2082)atC>atT	p.I694I	ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	694					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			accctgagatcgtgtttgctc	0.527000													24	35					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1246017	1246017	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:1246017G>A	ENST00000348261.5	+	5	885	c.637G>A	c.(637-639)Gtg>Atg	p.V213M	CACNA1H_ENST00000565831.1_Missense_Mutation_p.V213M|CACNA1H_ENST00000358590.4_Missense_Mutation_p.V213M	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	213					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CATCAACCGCGTGCCTAGTAA	0.652000													43	17					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465837	70465837	+	Splice_Site	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:70465837G>A	ENST00000373998.1	-	16	3345	c.2649_splice	c.e16+1	p.P883_splice	ZMYM3_ENST00000353904.2_Splice_Site_p.P895_splice|ZMYM3_ENST00000373984.3_Splice_Site_p.P897_splice|ZMYM3_ENST00000314425.5_Splice_Site_p.P895_splice|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373988.1_Splice_Site_p.P897_splice	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	895					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GAAACTCACCGGGATAGGCAT	0.582000													46	76					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94544910	94544910	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:94544910C>A	ENST00000370225.3	-	9	1293	c.1207G>T	c.(1207-1209)Gat>Tat	p.D403Y	ABCA4_ENST00000535735.1_Missense_Mutation_p.D403Y	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	403					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCAGGTGAATCAGGAGTGTAC	0.493000													34	48					4.74835e-14	5.25546e-14	1	1	0
PITPNM2	57605	broad.mit.edu	37	12	123470771	123470771	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:123470771C>T	ENST00000280562.5	-	25	4040	c.3835G>A	c.(3835-3837)Gac>Aac	p.D1279N	PITPNM2_ENST00000542749.1_Missense_Mutation_p.D1285N|PITPNM2_ENST00000392428.1_Missense_Mutation_p.D1006N|PITPNM2_ENST00000320201.4_Missense_Mutation_p.D1285N			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	0					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CGCAGAAAGTCGCCCTGGCCG	0.731000													6	9					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24818089	24818089	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:24818089C>T	ENST00000395799.3	+	17	4653	c.4524C>T	c.(4522-4524)ttC>ttT	p.F1508F	TNRC6A_ENST00000315183.7_Silent_p.F1459F|CTD-2515A14.1_ENST00000568895.1_RNA	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1508					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TAAATGCTTTCAGCAACTTCC	0.502000													13	12					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64603681	64603681	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:64603681G>A	ENST00000342711.5	-	13	1575	c.1576C>T	c.(1576-1578)Cta>Tta	p.L526L		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	526					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCCTCCTGTAGCCTCTGAAGC	0.701000											OREG0004017	type=REGULATORY REGION|Gene=CDC42BPG|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	10					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155532355	155532355	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:155532355G>C	ENST00000461783.3	+	17	4355	c.3082G>C	c.(3082-3084)Gat>Cat	p.D1028H	TIAM2_ENST00000456877.2_Missense_Mutation_p.D340H|TIAM2_ENST00000456144.1_Missense_Mutation_p.D1028H|TIAM2_ENST00000528391.2_Missense_Mutation_p.D364H|TIAM2_ENST00000318981.5_Missense_Mutation_p.D1028H|TIAM2_ENST00000529824.2_Missense_Mutation_p.D1028H|TIAM2_ENST00000367174.2_Missense_Mutation_p.D404H|TIAM2_ENST00000360366.4_Missense_Mutation_p.D1052H			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1028					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CAACGTCCCTGATATCACAAC	0.433000													17	29					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58790207	58790207	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:58790207G>A	ENST00000355431.3	+	8	827	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	ARID4A_ENST00000348476.3_Missense_Mutation_p.E152K|ARID4A_ENST00000395168.3_Missense_Mutation_p.E152K|ARID4A_ENST00000431317.2_Missense_Mutation_p.E152K	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	152					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTTTAGTACTGAAGATGAAAA	0.328000													14	26					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116060050	116060050	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:116060050C>T	ENST00000369271.3	-	15	2160	c.1860G>A	c.(1858-1860)caG>caA	p.Q620Q	AFAP1L2_ENST00000545353.1_Silent_p.Q673Q|AFAP1L2_ENST00000304129.4_Silent_p.Q620Q|AFAP1L2_ENST00000491814.1_5'UTR	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	620					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		AGGAGATTCTCTGCTGTTCCG	0.597000													31	74					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40704287	40704287	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:40704287G>A	ENST00000298910.7	+	31	4430	c.4372G>A	c.(4372-4374)Gat>Aat	p.D1458N		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1458	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGATGTTTCTGATGAGAAGCA	0.478000													47	57					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68956825	68956825	+	Splice_Site	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:68956825G>A	ENST00000288368.4	+	8	1220	c.943_splice	c.e8+1	p.A315_splice	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	315	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGATGGCACCGGTAAGTGATT	0.423000													4	61					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584766	82584766	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:82584766C>G	ENST00000423517.2	-	5	5840	c.5503G>C	c.(5503-5505)Gat>Cat	p.D1835H	PCLO_ENST00000333891.8_Missense_Mutation_p.D1835H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1766					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGAGATGCATCTTCAATGGGA	0.433000													69	116					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52668820	52668820	+	Nonsense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:52668820C>A	ENST00000356770.4	-	10	1005	c.1003G>T	c.(1003-1005)Gaa>Taa	p.E335*	PBRM1_ENST00000409057.1_Nonsense_Mutation_p.E367*|PBRM1_ENST00000337303.4_Nonsense_Mutation_p.E367*|PBRM1_ENST00000409767.1_Nonsense_Mutation_p.E367*|PBRM1_ENST00000409114.3_Nonsense_Mutation_p.E367*|PBRM1_ENST00000410007.1_Nonsense_Mutation_p.E367*|PBRM1_ENST00000394830.3_Nonsense_Mutation_p.E367*|PBRM1_ENST00000296302.7_Nonsense_Mutation_p.E367*			Q86U86	PB1_HUMAN	polybromo 1	367					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCTCCCTCTTCATAGCGTGCA	0.368000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								28	14					2.47511e-08	2.63703e-08	1	1	0
PTX3	5806	broad.mit.edu	37	3	157154797	157154797	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:157154797C>T	ENST00000295927.3	+	1	220	c.75C>T	c.(73-75)ctC>ctT	p.L25L	VEPH1_ENST00000392832.2_Intron|VEPH1_ENST00000392833.2_Intron|VEPH1_ENST00000362010.2_Intron|VEPH1_ENST00000543418.1_Intron	NM_002852.3	NP_002843.2	P26022	PTX3_HUMAN	pentraxin 3, long	25					inflammatory response	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)	10			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ATTATGATCTCATGTATGTGA	0.448000													34	71					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537943	114537943	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:114537943C>T	ENST00000371920.3	+	3	309	c.302C>T	c.(301-303)tCt>tTt	p.S101F	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	101						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GGATTCAAGTCTGGACAACAC	0.333000													51	105					0	0	1	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626546	44626546	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:44626546G>A	ENST00000576629.1	+	10	4536	c.4041G>A	c.(4039-4041)gcG>gcA	p.A1347A	ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000337845.7_Intron|ARL17A_ENST00000329240.4_Intron|LRRC37A2_ENST00000333412.3_Silent_p.A1347A|ARL17A_ENST00000445552.2_Intron			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1347						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		TCTCTGCAGCGAAGAGCCTCA	0.453000													30	88					0	0	1	0	0
ISY1	57461	broad.mit.edu	37	3	128853674	128853674	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:128853674C>A	ENST00000393292.3	-	8	603	c.542G>T	c.(541-543)cGt>cTt	p.R181L	ISY1_ENST00000393295.3_Splice_Site|ISY1_ENST00000273541.8_Splice_Site|ISY1-RAB43_ENST00000418265.1_Splice_Site|ISY1_ENST00000471497.1_Intron					ISY1 splicing factor homolog (S. cerevisiae)											endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|skin(1)	15						CAGAGACCTACGTTTCTTTTC	0.388000													18	52					2.27731e-05	2.38177e-05	1	1	0
RAI2	10742	broad.mit.edu	37	X	17818621	17818621	+	Missense_Mutation	SNP	T	T	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:17818621T>G	ENST00000545871.1	-	3	1970	c.1510A>C	c.(1510-1512)Aag>Cag	p.K504Q	RAI2_ENST00000451717.1_Missense_Mutation_p.K504Q|RAI2_ENST00000415486.3_Missense_Mutation_p.K454Q|RAI2_ENST00000360011.1_Missense_Mutation_p.K504Q|RAI2_ENST00000331511.1_Missense_Mutation_p.K504Q	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	504					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					TTCTTTAACTTTATGCTCCGG	0.438000													199	320					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26892128	26892128	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:26892128G>A	ENST00000407690.1	-	12	2043	c.1760C>T	c.(1759-1761)tCt>tTt	p.S587F	TFIP11_ENST00000407431.1_Missense_Mutation_p.S587F|TFIP11_ENST00000405938.1_Missense_Mutation_p.S587F|TFIP11_ENST00000407148.1_Missense_Mutation_p.S587F	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	587					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						GAGCTTGGCAGAGGAGTCGCT	0.577000													64	89					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	100009551	100009551	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:100009551C>T	ENST00000289371.5	+	18	3072	c.2870C>T	c.(2869-2871)cCt>cTt	p.P957L		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	957					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GATGAAATCCCTGTTCTTAAA	0.393000													11	26					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54656965	54656965	+	Silent	SNP	G	G	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:54656965G>T	ENST00000358389.3	+	17	2396	c.1542G>T	c.(1540-1542)ctG>ctT	p.L514L	CNOT3_ENST00000496327.1_Intron|CNOT3_ENST00000406403.1_Intron|CNOT3_ENST00000221232.5_Intron			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	321	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTGGTCCACTGAGGCACACCT	0.677000													16	26					5.03518e-11	5.4152e-11	1	1	0
PPP1CB	5500	broad.mit.edu	37	2	29011670	29011670	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:29011670C>T	ENST00000395366.2	+	6	1011	c.739C>T	c.(739-741)Cat>Tat	p.H247Y	PPP1CB_ENST00000358506.2_Missense_Mutation_p.H247Y|PPP1CB_ENST00000296122.6_Missense_Mutation_p.H247Y|SPDYA_ENST00000462832.1_3'UTR	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	247					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					TTGTCGAGCTCATCAGGTATG	0.398000													15	31					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154393830	154393830	+	Silent	SNP	A	A	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:154393830A>G	ENST00000435029.4	+	1	571	c.411A>G	c.(409-411)aaA>aaG	p.K137K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	137	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTACTCTGAAAGTGTCTTACT	0.373000													52	52					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356570	37356570	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:37356570C>T	ENST00000217420.1	+	2	1129	c.866C>T	c.(865-867)gCg>gTg	p.A289V		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	289					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CTATCGCGGGCGCGCGACTGG	0.527000													3	33					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163374320	163374320	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:163374320C>T	ENST00000332142.5	-	4	911	c.812G>A	c.(811-813)cGg>cAg	p.R271Q	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Missense_Mutation_p.R271Q	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	271					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGATGCTCTCCGTATACTACA	0.468000													21	42					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197398707	197398707	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:197398707C>T	ENST00000367397.1	+	4	1806	c.948C>T	c.(946-948)caC>caT	p.H316H	CRB1_ENST00000535699.1_Silent_p.H911H|CRB1_ENST00000367400.3_Silent_p.H935H|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Silent_p.H823H|CRB1_ENST00000544212.1_Silent_p.H416H			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	935	EGF-like 8.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.H935Q(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGTGTCCTCACGGAGCCCAGT	0.532000													29	29					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116340200	116340200	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:116340200C>T	ENST00000397752.3	+	2	1262	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	MET_ENST00000436117.2_Silent_p.A354A|MET_ENST00000318493.6_Silent_p.A354A	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	354	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CAGATTCTGCCGAACCAATGG	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				13	27					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811134	123811134	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:123811134G>A	ENST00000307033.2	+	1	885	c.811G>A	c.(811-813)Gtc>Atc	p.V271I		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V271I(1)		autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGACAAGGCCGTCTCTGTGCT	0.493000													35	72					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57869285	57869285	+	Silent	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:57869285G>C	ENST00000393797.2	-	14	1887	c.1695C>G	c.(1693-1695)ctC>ctG	p.L565L	ARHGAP9_ENST00000356411.2_Silent_p.L494L|ARHGAP9_ENST00000430041.2_Silent_p.L291L|ARHGAP9_ENST00000393791.3_Silent_p.L475L|ARHGAP9_ENST00000550288.1_Silent_p.L554L|ARHGAP9_ENST00000424809.2_Silent_p.L475L			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	494	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGCGGCTGCTGAGGCGCAGCA	0.731000													6	12					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6661790	6661790	+	Missense_Mutation	SNP	A	A	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:6661790A>G	ENST00000299441.3	-	2	1466	c.1055T>C	c.(1054-1056)gTg>gCg	p.V352A		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	352	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCATCTCGCACATGCACAGT	0.597000													49	92					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161480678	161480678	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:161480678C>T	ENST00000271450.6	+	5	712	c.674C>T	c.(673-675)gCg>gTg	p.A225V	FCGR2A_ENST00000367972.4_Missense_Mutation_p.A224V|FCGR2A_ENST00000467525.1_3'UTR	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	225						integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTGGTCATTGCGACTGCTGTA	0.502000													80	99					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8828905	8828905	+	Splice_Site	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:8828905G>A	ENST00000359865.3	+	16	4864		c.e16-1		SOGA2_ENST00000306329.11_Splice_Site|SOGA2_ENST00000517570.1_Splice_Site|SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000400050.3_Splice_Site|SOGA2_ENST00000306285.7_Intron	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2																		GTTCTGTCCAGAACCAAACTG	0.483000													24	47					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9546591	9546591	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:9546591C>T	ENST00000378429.3	-	6	1977	c.1431G>A	c.(1429-1431)gtG>gtA	p.V477V	PAK7_ENST00000378423.1_Silent_p.V477V|PAK7_ENST00000353224.5_Silent_p.V477V	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	477	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CCATTTTCTTCACTGCAACTT	0.458000													53	83					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186168522	186168522	+	Silent	SNP	T	T	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:186168522T>G	ENST00000504273.1	+	2	306	c.12T>G	c.(10-12)gcT>gcG	p.A4A	SNX25_ENST00000264694.8_Silent_p.A4A			Q9H3E2	SNX25_HUMAN	sorting nexin 25	4	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TGGATAAAGCTCTGAAAGAAG	0.308000													7	78					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222802495	222802495	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:222802495G>A	ENST00000344922.5	+	4	1958	c.1933G>A	c.(1933-1935)Gaa>Aaa	p.E645K	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344507.1_Intron|MIA3_ENST00000344441.6_Missense_Mutation_p.E645K	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	645					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		CAGAGAACTGGAAGACGAGGT	0.448000													57	71					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233807161	233807161	+	Missense_Mutation	SNP	T	T	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:233807161T>G	ENST00000366621.3	+	3	1064	c.896T>G	c.(895-897)cTg>cGg	p.L299R	KCNK1_ENST00000366620.1_Missense_Mutation_p.L183R|KCNK1_ENST00000472190.1_3'UTR	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	299						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CATGACCAACTGTCCTTCTCC	0.488000													16	34					0	0	1	0	0
PITX1	5307	broad.mit.edu	37	5	134365003	134365003	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:134365003G>A	ENST00000265340.7	-	3	827	c.411C>T	c.(409-411)ttC>ttT	p.F137F	PITX1_ENST00000506438.1_Silent_p.F137F	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	137						nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		GCCGGTTCTTGAACCAGACCT	0.701000													38	53					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102294702	102294702	+	RNA	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr15:102294702C>T	ENST00000561463.1	+	0	2748																											GAGGCGTCGGCAGAGCAGGCA	0.607000													6	10					0	0	1	0	0
GALNS	2588	broad.mit.edu	37	16	88902658	88902658	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:88902658G>A	ENST00000268695.5	-	6	672	c.584C>T	c.(583-585)cCt>cTt	p.P195L	GALNS_ENST00000542788.1_Missense_Mutation_p.P120L	NM_000512.4	NP_000503.1	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	195						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(8)	22				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	CAGATTAATAGGAAATTCTTC	0.512000													11	12					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149557915	149557915	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:149557915G>C	ENST00000223210.4	+	7	1911	c.1666G>C	c.(1666-1668)Gag>Cag	p.E556Q		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	556					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						GGCCAACATGGAGCACTTTTT	0.537000													23	47					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104312897	104312897	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:104312897C>T	ENST00000389120.3	+	10	1192	c.1102C>T	c.(1102-1104)Cgg>Tgg	p.R368W		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	368					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding	p.R368W(1)		breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GGTGGAATTGCGGAGTGCAGT	0.468000													4	179					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133802609	133802609	+	Missense_Mutation	SNP	G	G	A	rs144415484		TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:133802609G>A	ENST00000367895.5	+	12	1443	c.979G>A	c.(979-981)Gat>Aat	p.D327N	EYA4_ENST00000431403.2_Missense_Mutation_p.D327N|EYA4_ENST00000430974.2_Missense_Mutation_p.D279N|EYA4_ENST00000355167.3_Missense_Mutation_p.D327N|EYA4_ENST00000531901.1_Missense_Mutation_p.D333N|EYA4_ENST00000355286.6_Missense_Mutation_p.D304N|EYA4_ENST00000525849.1_Missense_Mutation_p.D304N|EYA4_ENST00000452339.2_Missense_Mutation_p.D273N	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	327					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		AGGAGAGTTCGATACCATGCA	0.388000													15	93					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187531923	187531923	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:187531923G>A	ENST00000261023.3	+	23	2567	c.2293G>A	c.(2293-2295)Gat>Aat	p.D765N	ITGAV_ENST00000433736.2_Missense_Mutation_p.D719N|ITGAV_ENST00000374907.3_Missense_Mutation_p.D729N|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	765					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TCACAAAGTTGATCTTGCTGT	0.333000													22	43					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152815068	152815068	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:152815068C>T	ENST00000370186.1	+	9	1736	c.1410C>T	c.(1408-1410)acC>acT	p.T470T	ATP2B3_ENST00000263519.4_Silent_p.T484T|ATP2B3_ENST00000393842.1_Silent_p.T470T|ATP2B3_ENST00000370181.2_Silent_p.T470T|ATP2B3_ENST00000349466.2_Silent_p.T484T|ATP2B3_ENST00000359149.3_Silent_p.T484T			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	484					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCGTATGACCGTGGTCCAGT	0.612000													57	123					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501704	140501704	+	Missense_Mutation	SNP	T	T	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:140501704T>C	ENST00000194152.1	+	1	124	c.124T>C	c.(124-126)Tcc>Ccc	p.S42P		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		42	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGCGGCTCCTTTGTAGC	0.542000													20	40					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98515126	98515126	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:98515126C>T	ENST00000359863.4	+	20	2655	c.2446C>T	c.(2446-2448)Cgg>Tgg	p.R816W	TRRAP_ENST00000355540.3_Missense_Mutation_p.R816W|TRRAP_ENST00000446306.3_Missense_Mutation_p.R815W	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	816					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.R816W(2)		NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGTCCCTGTGCGGCTGAGCTC	0.577000													29	37					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96933089	96933089	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:96933089C>G	ENST00000488633.1	+	2	389	c.170C>G	c.(169-171)tCt>tGt	p.S57C	CIAO1_ENST00000469320.1_3'UTR	NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	57					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						TCTGTCCTTTCTGAAGGCCAC	0.577000													92	112					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739603	62739603	+	Silent	SNP	T	T	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:62739603T>C	ENST00000371153.4	-	3	1551	c.1173A>G	c.(1171-1173)gtA>gtG	p.V391V	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	391										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCAGTTGGGCTACAGTGAACT	0.527000													4	114					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80790229	80790229	+	Nonsense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:80790229G>T	ENST00000269394.3	-	2	935	c.102C>A	c.(100-102)tgC>tgA	p.C34*	TBCD_ENST00000539345.2_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	34						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ACTTCTCATTGCAAGTAAAGG	0.413000													34	12					9.65021e-13	1.04774e-12	1	1	0
TNIP1	10318	broad.mit.edu	37	5	150422172	150422172	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:150422172C>T	ENST00000389378.2	-	11	1651	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	TNIP1_ENST00000523338.1_Missense_Mutation_p.E355K|TNIP1_ENST00000524280.1_Missense_Mutation_p.E355K|TNIP1_ENST00000521591.1_Missense_Mutation_p.E355K|TNIP1_ENST00000520931.1_Missense_Mutation_p.E302K|TNIP1_ENST00000518977.1_Missense_Mutation_p.E355K|TNIP1_ENST00000523200.1_Missense_Mutation_p.E355K|TNIP1_ENST00000521423.1_Intron|TNIP1_ENST00000522226.1_Missense_Mutation_p.E355K|TNIP1_ENST00000315050.7_Missense_Mutation_p.E355K	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	355	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCTCCCGCTCGGCCTCCAGG	0.572000													27	29					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16255380	16255380	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:16255380G>C	ENST00000375759.3	+	11	2849	c.2645G>C	c.(2644-2646)cGa>cCa	p.R882P		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	882					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTTTTGACTCGAGTGAAAGAG	0.463000													70	87					0	0	1	0	0
NXF1	10482	broad.mit.edu	37	11	62563597	62563597	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:62563597C>T	ENST00000532297.1	-	17	2031	c.1402G>A	c.(1402-1404)Gag>Aag	p.E468K	NXF1_ENST00000531709.2_3'UTR|NXF1_ENST00000294172.2_Missense_Mutation_p.E468K			Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	468	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTGGGCAACTCATTGAGGAAG	0.557000													24	46					0	0	1	0	0
HNRNPD	3184	broad.mit.edu	37	4	83280732	83280732	+	Missense_Mutation	SNP	A	A	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:83280732A>T	ENST00000313899.7	-	3	628	c.351T>A	c.(349-351)ttT>ttA	p.F117L	HNRNPD_ENST00000541060.1_Intron|HNRNPD_ENST00000352301.4_Missense_Mutation_p.F98L|HNRNPD_ENST00000543098.1_Missense_Mutation_p.F65L|HNRNPD_ENST00000353341.4_Missense_Mutation_p.F117L	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	117	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						CAAATTTGGAAAAGTAGTCCT	0.378000													43	43					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131808	72131808	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:72131808C>G	ENST00000265381.4	-	2	541	c.319G>C	c.(319-321)Gag>Cag	p.E107Q		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	107					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						TGCGCGCGCTCCGCATCGTAG	0.721000													7	16					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072656	17072656	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:17072656G>C	ENST00000359963.3	-	1	1044	c.785C>G	c.(784-786)tCt>tGt	p.S262C		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	262					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.S262C(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGCAGGACTAGAAAGACGGGC	0.507000													61	100					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569536	241569536	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:241569536G>A	ENST00000319838.5	+	6	1109	c.167G>A	c.(166-168)cGc>cAc	p.R56H	GPR35_ENST00000430267.1_Missense_Mutation_p.R56H|GPR35_ENST00000407714.1_Missense_Mutation_p.R56H|GPR35_ENST00000403859.1_Missense_Mutation_p.R56H|GPR35_ENST00000438013.2_Missense_Mutation_p.R87H	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	56						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		ACGGAGACCCGCATCTACATG	0.642000													35	44					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408552	29408552	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:29408552G>A	ENST00000444197.2	+	1	1470	c.760G>A	c.(760-762)Gca>Aca	p.A254T	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTATGGCACCGCACTCTTTAT	0.582000													5	361					0	0	1	0	0
MIR219A1	407002	broad.mit.edu	37	6	33175633	33175633	+	RNA	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:33175633G>C	ENST00000362166.1	+	0	22					NR_029633.1																						CGCGGCTCCTGATTGTCCAAA	0.657000													11	8					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45107797	45107797	+	Silent	SNP	G	G	A	rs143773984	byFrequency	TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr21:45107797G>A	ENST00000340648.4	+	13	1659	c.1542G>A	c.(1540-1542)ccG>ccA	p.P514P		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	514					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		GAGGGTCCCCGACAGGTGGAG	0.607000													13	68					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44107644	44107644	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:44107644C>G	ENST00000420999.1	-	7	1068	c.985G>C	c.(985-987)Gac>Cac	p.D329H		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	329	DM10 2.						calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						AACTCTTGGTCTACTTTTCCT	0.413000													5	3					0	0	1	0	0
ZNF48	197407	broad.mit.edu	37	16	30409140	30409140	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:30409140G>A	ENST00000320159.2	+	2	945	c.569G>A	c.(568-570)cGc>cAc	p.R190H		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						GCTGGTGAGCGCCCCACTATC	0.597000													3	45					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94642442	94642442	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:94642442G>C	ENST00000304338.3	+	2	323	c.169G>C	c.(169-171)Gaa>Caa	p.E57Q	PPP4R4_ENST00000555690.1_3'UTR|PPP4R4_ENST00000328839.3_Missense_Mutation_p.E57Q	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	57						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CAGTGATATTGAAAGGGCTGT	0.383000													30	16					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96933415	96933415	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:96933415delC	ENST00000488633.1	+	3	560	c.341delC	c.(340-342)gcfs	p.A114fs	CIAO1_ENST00000469320.1_3'UTR	NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	114					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						GTGGCTTGGGCCCCATCTGGC	0.542													27	45	---	---	---	---					
FOXC1	2296	broad.mit.edu	37	6	1611463	1611465	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:1611463_1611465delCAG	ENST00000380874.2	+	1	783_785	c.783_785delCAG	c.(781-786)gac>ga	p.DS261del		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	261					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGAGCCCCGACAGCAGCAGCAGC	0.793													2	4	---	---	---	---					
RRAGD	58528	broad.mit.edu	37	6	90121645	90121647	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:90121645_90121647delTCC	ENST00000369415.4	-	1	342_344	c.66_68delGGA	c.(64-69)gat>ga	p.ED22del	RRAGD_ENST00000359203.2_5'UTR	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	22					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CACCAGctcatcctcctcctcct	0.754													2	4	---	---	---	---					
PHACTR2	9749	broad.mit.edu	37	6	144081695	144081696	+	Frame_Shift_Ins	INS	-	-	A			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:144081695_144081696insA	ENST00000427704.2	+	5	709_710	c.579_580insA	c.(577-582)ataaaafs	p.IK193fs	PHACTR2_ENST00000305766.6_Intron|PHACTR2_ENST00000367584.4_Intron|PHACTR2_ENST00000440869.2_Frame_Shift_Ins_p.IK204fs|PHACTR2_ENST00000367582.3_Intron	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	193							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGCCTCCCATTAAAAAAAATAC	0.569													7	134	---	---	---	---					
XKR5	389610	broad.mit.edu	37	8	6679315	6679316	+	RNA	DEL	CC	CC	-	rs58387909	by1000genomes	TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:6679315_6679316delCC	ENST00000518724.1	-	0	958							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		cacacacacaccccccacacac	0.406													3	6	---	---	---	---					
GOT1L1	137362	broad.mit.edu	37	8	37791833	37791834	+	Frame_Shift_Ins	INS	-	-	T			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:37791833_37791834insT	ENST00000307599.4	-	9	1342_1343	c.1243_1244insA	c.(1243-1245)actfs	p.T415fs		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	415					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			TCCAATCAGTGTTTTTTTTTCC	0.371													7	80	---	---	---	---					
RAB2A	5862	broad.mit.edu	37	8	61533317	61533317	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:61533317delG	ENST00000262646.7	+	8	979	c.628delG	c.(628-630)gcfs	p.G210fs	RAB2A_ENST00000531289.1_Frame_Shift_Del_p.G186fs|RAB2A_ENST00000529579.1_Frame_Shift_Del_p.A174fs|RAB2A_ENST00000530071.1_3'UTR	NM_002865.2	NP_002856.1	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	210					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(1)|lung(4)	6			BRCA - Breast invasive adenocarcinoma(89;0.0805)			GGCTGGGGGCGGCTGCTGTTG	0.502													22	37	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112628669	112628669	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:112628669delT	ENST00000550722.1	-	60	9350	c.8955delA	c.(8953-8955)tcfs	p.S2985fs	HECTD4_ENST00000430131.2_Frame_Shift_Del_p.S2709fs|HECTD4_ENST00000377560.5_Frame_Shift_Del_p.S2959fs	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CACTGTCCTCTGATTTCCAGG	0.602													2	4	---	---	---	---					
RP11-160E2.17	0	broad.mit.edu	37	17	18988562	18988562	+	RNA	DEL	T	T	-			TCGA-KU-A6H7-06A-21D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d10e2807-bbf6-43fc-923e-7fef0bb91f32	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:18988562delT	ENST00000442355.2	+	0	272																											CTGATGTGTGTTTTTTTTTTT	0.279													3	4	---	---	---	---