Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TOMM40	10452	broad.mit.edu	37	19	45406290	45406290	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:45406290C>T	ENST00000426677.2	+	9	1130	c.950C>T	c.(949-951)tCt>tTt	p.S317F	TOMM40_ENST00000252487.5_Missense_Mutation_p.S317F|TOMM40_ENST00000592434.1_3'UTR|TOMM40_ENST00000405636.2_Missense_Mutation_p.S317F	NM_001128917.1	NP_001122389.1	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)	317					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		CCTGCAGGCTCTGTGGATAGC	0.602000													10	63					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161755	57161755	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:57161755C>G	ENST00000371244.4	+	6	777	c.711C>G	c.(709-711)ctC>ctG	p.L237L		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	237	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						CAGAATATCTCAATCGTTCTG	0.423000													75	463					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36870321	36870321	+	Nonsense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:36870321G>C	ENST00000279024.4	-	3	483	c.212C>G	c.(211-213)tCa>tGa	p.S71*		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	71										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GAGGCAGTGTGAGTAGGGAGC	0.572000													10	100					0	0	1	0	0
PTER	9317	broad.mit.edu	37	10	16553183	16553183	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:16553183G>A	ENST00000378000.1	+	6	1224	c.978G>A	c.(976-978)ctG>ctA	p.L326L	PTER_ENST00000298942.3_Silent_p.L326L|PTER_ENST00000535784.2_Silent_p.L326L|PTER_ENST00000423462.2_Silent_p.L279L	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	326					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						AAATGTTGCTGAGAGGCATAA	0.393000													19	120					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947596	121947596	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:121947596G>A	ENST00000377069.4	-	11	1734	c.1328C>T	c.(1327-1329)tCt>tTt	p.S443F	KDM2B_ENST00000538046.2_Missense_Mutation_p.S384F|KDM2B_ENST00000536437.1_Missense_Mutation_p.S357F|KDM2B_ENST00000377071.4_Missense_Mutation_p.S474F	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	474					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CGACTCATTAGACAAAGTCCT	0.597000													11	97					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869562	36869562	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:36869562G>A	ENST00000279024.4	-	3	1242	c.971C>T	c.(970-972)tCa>tTa	p.S324L		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	324										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				ATTGGCCTCTGAGAGAGGCAG	0.498000													26	285					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746154	47746154	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:47746154G>A	ENST00000360380.3	-	13	2339	c.1976C>T	c.(1975-1977)tCa>tTa	p.S659L	STIL_ENST00000337817.5_Missense_Mutation_p.S659L|STIL_ENST00000243182.6_Missense_Mutation_p.S659L|STIL_ENST00000396221.2_Missense_Mutation_p.S659L|STIL_ENST00000371877.3_Missense_Mutation_p.S659L			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	659	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol		p.S659L(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AGGACTACTTGAAGAACAGAA	0.468000													16	148					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26695086	26695086	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr22:26695086C>T	ENST00000529632.2	+	5	1495	c.1299C>T	c.(1297-1299)tgC>tgT	p.C433C	SEZ6L_ENST00000343706.4_Silent_p.C433C|SEZ6L_ENST00000248933.6_Silent_p.C433C|SEZ6L_ENST00000360929.3_Silent_p.C433C|SEZ6L_ENST00000404234.3_Silent_p.C433C|SEZ6L_ENST00000402979.1_Silent_p.C206C|SEZ6L_ENST00000403121.1_Silent_p.C206C	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	433	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TGCTGACATGCATCAATGCCT	0.597000													4	36					0	0	1	0	0
RBMS2	5939	broad.mit.edu	37	12	56963764	56963764	+	Missense_Mutation	SNP	A	A	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:56963764A>T	ENST00000262031.5	+	4	469	c.374A>T	c.(373-375)cAg>cTg	p.Q125L	RBMS2_ENST00000549945.1_3'UTR|RBMS2_ENST00000550726.1_5'UTR|RBMS2_ENST00000552247.2_Missense_Mutation_p.Q125L|RBMS2_ENST00000542360.1_5'UTR	NM_002898.3	NP_002889.1	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting protein 2	125	RRM 1.				RNA processing	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(3)|skin(2)|urinary_tract(1)	18						GTACAGGCACAGATGGCAAAG	0.502000													4	106					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725972	123725972	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:123725972G>A	ENST00000223642.1	-	34	4294	c.4265C>T	c.(4264-4266)gCg>gTg	p.A1422V		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1422					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GTCCATCACCGCATGAGAGGA	0.358000													4	148					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100365499	100365499	+	RNA	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr7:100365499C>T	ENST00000542585.1	+	0	5054				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.R1636W(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACAAGGCCGGGTGACCAT	0.577000													6	32					0	0	1	0	0
GOLGA7B	401647	broad.mit.edu	37	10	99623701	99623701	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:99623701C>G	ENST00000370602.1	+	3	218	c.153C>G	c.(151-153)ctC>ctG	p.L51L		NM_001010917.2	NP_001010917.1	Q2TAP0	GOG7B_HUMAN	golgin A7 family, member B	51						Golgi membrane				endometrium(1)|large_intestine(3)|prostate(1)	5						AGCGGCAGCTCTTTGAAGAGA	0.602000													11	86					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192125823	192125823	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:192125823G>A	ENST00000454309.2	-	1	1015	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W	FGF12_ENST00000430714.1_Intron|FGF12_ENST00000264730.3_Intron|FGF12_ENST00000450716.1_Intron|FGF12_ENST00000445105.1_Intron	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	64					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		CCTGGTCTCCGCCTCACCGGC	0.667000													34	247					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96166282	96166282	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr4:96166282C>T	ENST00000453304.1	-	6	1137	c.789G>A	c.(787-789)tgG>tgA	p.W263*	UNC5C_ENST00000506749.1_Nonsense_Mutation_p.W263*	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	263	TSP type-1 1.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCCAGGTGGACCAGCCACCGT	0.493000													7	42					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73680429	73680429	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:73680429C>G	ENST00000264448.6	+	8	6883	c.6772C>G	c.(6772-6774)Ctt>Gtt	p.L2258V	ALMS1_ENST00000409009.1_Missense_Mutation_p.L2216V|ALMS1_ENST00000377715.1_Missense_Mutation_p.L2258V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2258					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TGCTAAAACTCTTAAGGAAAT	0.398000													14	81					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138529060	138529060	+	Splice_Site	SNP	A	A	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr7:138529060A>G	ENST00000440172.1	-	18	5501		c.e18+1		KIAA1549_ENST00000422774.1_Splice_Site|KIAA1549_ENST00000242365.4_Splice_Site	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549							integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGCCACATATACCTGTGGTAC	0.557000			O	BRAF	pilocytic astrocytoma								6	33					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84533044	84533044	+	RNA	SNP	T	T	C	rs530720	by1000genomes	TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:84533044T>C	ENST00000527857.1	+	0	3066					NR_026851.1																						TTTTCTGATATTGACCATGAC	0.458000													3	37					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400709	195400709	+	RNA	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:195400709C>T	ENST00000445430.1	+	0	1305																											ACGGGAATGGCCAGGATCAGA	0.592000													4	67					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26434338	26434338	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr13:26434338G>C	ENST00000381655.2	+	31	3104	c.2962G>C	c.(2962-2964)Gtg>Ctg	p.V988L	ATP8A2_ENST00000255283.8_Missense_Mutation_p.V923L|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	948					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTCAGATACTGTGTTGACAAG	0.343000													11	90					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145579649	145579649	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:145579649C>T	ENST00000331890.5	-	8	1515	c.1451G>A	c.(1450-1452)cGg>cAg	p.R484Q	FBXL6_ENST00000526524.1_Intron|FBXL6_ENST00000455319.2_Missense_Mutation_p.R478Q	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	484					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TGGTGTGACCCGGGTGCCCCT	0.632000													15	71					0	0	1	0	0
OCM2	4951	broad.mit.edu	37	7	97617777	97617777	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr7:97617777G>A	ENST00000257627.4	-	2	236	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W	OCM2_ENST00000473987.2_5'UTR	NM_006188.3	NP_006179.2	P0CE71	OCM2_HUMAN	oncomodulin 2	49	EF-hand 1.						calcium ion binding			lung(4)	4						TCTATGAACCGGAAAACATCC	0.507000													20	129					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101493408	101493408	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:101493408G>A	ENST00000392979.3	+	21	2315	c.1954G>A	c.(1954-1956)Gaa>Aaa	p.E652K	ANO4_ENST00000550015.1_Missense_Mutation_p.E207K|ANO4_ENST00000392977.3_Missense_Mutation_p.E687K|ANO4_ENST00000299222.9_Missense_Mutation_p.E207K	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	687						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ACATGGACCTGAAAGGAAAAT	0.358000										HNSCC(74;0.22)			10	93					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													5	30					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103412503	103412503	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:103412503C>T	ENST00000358392.2	-	42	3531	c.3214G>A	c.(3214-3216)Gga>Aga	p.G1072R	COL11A1_ENST00000512756.1_Missense_Mutation_p.G944R|COL11A1_ENST00000370096.3_Missense_Mutation_p.G1060R|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1021R	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1060	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.G1072*(1)|p.G1060*(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCACGTTCTCCTGGTGAGCCC	0.468000													9	29					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96956103	96956103	+	Silent	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:96956103G>C	ENST00000323853.5	-	20	2780	c.2703C>G	c.(2701-2703)ctC>ctG	p.L901L	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	901	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TTTCTGCATTGAGCATGTCAG	0.488000													28	227					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43318566	43318566	+	Splice_Site	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:43318566G>A	ENST00000374518.4	+	20	3196	c.3132_splice	c.e20-1	p.G1045_splice		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1045					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ATACCTGTAGGGAATGTTTAA	0.388000													5	128					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	92002396	92002396	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:92002396C>A	ENST00000450295.1	-	12	2011	c.1235G>T	c.(1234-1236)aGg>aTg	p.R412M	SEMA4D_ENST00000339861.4_Missense_Mutation_p.R412M|SEMA4D_ENST00000438547.2_Missense_Mutation_p.R412M|SEMA4D_ENST00000356444.2_Missense_Mutation_p.R412M|SEMA4D_ENST00000343780.4_Missense_Mutation_p.R412M|SEMA4D_ENST00000455551.2_Missense_Mutation_p.R412M|SEMA4D_ENST00000420987.1_Missense_Mutation_p.R412M|SEMA4D_ENST00000422704.2_Missense_Mutation_p.R412M			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	412	Sema.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						CTTGATTAACCTGGGCCTGTT	0.507000													4	89					0.150653	0.151909	1	1	0
ASPA	443	broad.mit.edu	37	17	3386832	3386832	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr17:3386832G>C	ENST00000263080.2	+	3	630	c.472G>C	c.(472-474)Gag>Cag	p.E158Q	SPATA22_ENST00000541913.1_Intron|ASPA_ENST00000456349.2_Missense_Mutation_p.E158Q	NM_000049.2	NP_000040.1	P45381	ACY2_HUMAN	aspartoacylase	158					aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|stomach(1)|urinary_tract(1)	17					L-Aspartic Acid(DB00128)	TTATCTGATTGAGCATCCTTC	0.403000													11	93					0	0	1	0	0
MC2R	4158	broad.mit.edu	37	18	13885017	13885017	+	Silent	SNP	G	G	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr18:13885017G>T	ENST00000327606.3	-	2	681	c.501C>A	c.(499-501)atC>atA	p.I167I		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	167					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	GATGGGAGAAGATCACCATGG	0.577000													10	85					1.58986e-06	1.68749e-06	1	1	0
TRIM13	10206	broad.mit.edu	37	13	50586100	50586100	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr13:50586100C>G	ENST00000378182.3	+	2	762	c.24C>G	c.(22-24)ctC>ctG	p.L8L	TRIM13_ENST00000298772.5_Silent_p.L11L|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000420995.2_Silent_p.L8L|TRIM13_ENST00000356017.4_Silent_p.L11L|TRIM13_ENST00000457662.2_Silent_p.L8L	NM_001007278.1|NM_005798.3|NM_052811.2|NM_213590.1	NP_001007279.1|NP_005789.2|NP_434698.1|NP_998755.1	O60858	TRI13_HUMAN	tripartite motif containing 13	8					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		AAGAAGATCTCACATGCCCTA	0.383000													30	159					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68111170	68111170	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:68111170C>T	ENST00000262215.3	-	39	5938	c.5549G>A	c.(5548-5550)tGa>tAa	p.*1850*	ARFGEF1_ENST00000520381.1_Intron|ARFGEF1_ENST00000517955.1_5'UTR	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	0					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AAGTTCCCATCATTGCTTGTT	0.398000													5	103					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122399744	122399744	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:122399744G>A	ENST00000474629.2	+	1	280	c.14G>A	c.(13-15)gGc>gAc	p.G5D		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GCTGTGCCCGGCTCCTTCCCG	0.632000													3	10					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19591191	19591191	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr5:19591191C>T	ENST00000507958.1	-	9	1964	c.974G>A	c.(973-975)aGa>aAa	p.R325K	CDH18_ENST00000506372.1_Missense_Mutation_p.R325K|CDH18_ENST00000511273.1_Missense_Mutation_p.R325K|CDH18_ENST00000274170.4_Missense_Mutation_p.R325K|CDH18_ENST00000502796.1_Missense_Mutation_p.R325K|CDH18_ENST00000382275.1_Missense_Mutation_p.R325K			Q13634	CAD18_HUMAN	cadherin 18, type 2	325	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GATTCCTTCTCTGGTCTCTTT	0.403000													19	123					0	0	1	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214124	11214124	+	Missense_Mutation	SNP	T	T	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:11214124T>G	ENST00000533467.1	-	1	769	c.770A>C	c.(769-771)aAc>aCc	p.N257T	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	257					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GACAGGTTTGTTTTCCAGACT	0.408000													45	246					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247695055	247695055	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:247695055G>A	ENST00000366487.3	-	2	1120	c.759C>T	c.(757-759)taC>taT	p.Y253Y	GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000366491.2_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGATGCTCCCGTAAAACAGAG	0.547000													11	119					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152655237	152655237	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr6:152655237C>T	ENST00000367255.5	-	77	13301	c.12700G>A	c.(12700-12702)Gag>Aag	p.E4234K	SYNE1_ENST00000341594.5_Missense_Mutation_p.E4099K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E4163K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E4234K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E4163K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4234					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGAAGATCCTCTTCCCTTTGC	0.398000										HNSCC(10;0.0054)			5	204					0	0	1	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451531	22451531	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:22451531C>T	ENST00000325870.1	+	2	1361	c.1136C>T	c.(1135-1137)tCa>tTa	p.S379L		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	379					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CTAGCAAACTCAGAAGAACTG	0.428000													14	100					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143956410	143956410	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:143956410C>T	ENST00000292427.4	-	8	1393	c.1361G>A	c.(1360-1362)cGc>cAc	p.R454H	CYP11B1_ENST00000517471.1_Intron|CYP11B1_ENST00000377675.3_Missense_Mutation_p.R525H	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	454			R -> C (in AH4).		aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTCTGCCAGGCGCCGCCCAAG	0.682000									Familial Hyperaldosteronism type I				32	98					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76725349	76725349	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr4:76725349C>G	ENST00000538159.1	+	19	2076	c.2076C>G	c.(2074-2076)ctC>ctG	p.L692L	USO1_ENST00000514213.2_Silent_p.L668L			O60763	USO1_HUMAN	USO1 vesicle transport factor	683					intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATGAACAGCTCCAGACGGCAG	0.383000													10	27					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203816649	203816649	+	Silent	SNP	A	A	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:203816649A>T	ENST00000545588.1	+	12	5207	c.1380A>T	c.(1378-1380)gcA>gcT	p.A460A	ZC3H11A_ENST00000367214.1_Silent_p.A460A|ZC3H11A_ENST00000332127.4_Silent_p.A460A|ZC3H11A_ENST00000367212.3_Silent_p.A460A|ZC3H11A_ENST00000367210.1_Silent_p.A460A	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	460							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGGAGCCTGCAGGTAAAACAA	0.453000													18	113					0	0	1	0	0
RFX2	5990	broad.mit.edu	37	19	6040136	6040136	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:6040136G>A	ENST00000303657.5	-	5	526	c.377C>T	c.(376-378)gCg>gTg	p.A126V	RFX2_ENST00000592546.1_Missense_Mutation_p.A126V|RFX2_ENST00000359161.3_Missense_Mutation_p.A126V	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GGAGGGGACCGCTGGCGGGGA	0.677000													15	91					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8654233	8654233	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:8654233C>T	ENST00000270328.4	-	17	2317	c.2051G>A	c.(2050-2052)cGa>cAa	p.R684Q	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.R171Q|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R684Q			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	684	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GCCCAGGACTCGGTCGCAGCC	0.692000													5	69					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121616407	121616407	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr4:121616407C>T	ENST00000264808.3	-	16	1992	c.1752G>A	c.(1750-1752)ctG>ctA	p.L584L	PRDM5_ENST00000515109.1_3'UTR|PRDM5_ENST00000506065.1_5'UTR|PRDM5_ENST00000428209.2_Silent_p.L553L	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	584					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GCATTTTCTTCAGGCTAAAAG	0.358000													12	80					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45689949	45689949	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr17:45689949C>G	ENST00000322157.4	+	18	2456	c.2219C>G	c.(2218-2220)tCc>tGc	p.S740C	NPEPPS_ENST00000530173.1_Missense_Mutation_p.S736C|RP11-580I16.2_ENST00000582066.1_RNA|RP11-580I16.2_ENST00000582389.1_RNA|NPEPPS_ENST00000544660.1_Missense_Mutation_p.S660C	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	740					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						CAGATTCTCTCCGCTGATCTG	0.408000													17	97					0	0	1	0	0
MEX3D	399664	broad.mit.edu	37	19	1556694	1556694	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:1556694G>T	ENST00000402693.4	-	2	823	c.824C>A	c.(823-825)aCc>aAc	p.T275N	MEX3D_ENST00000388824.6_Missense_Mutation_p.T275N	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	275	KH 2.				mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCTGGATGGTGGTCTGTCC	0.716000													6	62					3.59834e-05	3.72136e-05	1	1	0
LAMC2	3918	broad.mit.edu	37	1	183208566	183208566	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:183208566C>T	ENST00000264144.4	+	20	3002	c.2937C>T	c.(2935-2937)atC>atT	p.I979I	LAMC2_ENST00000493293.1_Silent_p.I979I	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	979	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TCTCCTACATCAGCCAGAAGG	0.517000													34	203					0	0	1	0	0
CLK4	57396	broad.mit.edu	37	5	178044413	178044413	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr5:178044413G>C	ENST00000316308.4	-	4	575	c.407C>G	c.(406-408)tCc>tGc	p.S136C	CLK4_ENST00000522749.1_Intron	NM_020666.2	NP_065717.1	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	136						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(2)	21	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		TATACTCCTGGATCTTTTCCT	0.433000													10	64					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229357	90229357	+	RNA	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:90229357G>A	ENST00000390278.2	+	0	197																											CCTGGTATCTGCAGAAACCAG	0.493000													4	89					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98411122	98411122	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:98411122G>C	ENST00000339364.5	-	6	990	c.871C>G	c.(871-873)Ccc>Gcc	p.P291A	PIK3AP1_ENST00000468783.1_5'UTR|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.P113A	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	291	DBB.					cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GTGTTGTAGGGCACAATTTTA	0.453000													25	86					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308903	248308903	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:248308903G>A	ENST00000366476.1	+	1	454	c.454G>A	c.(454-456)Ggc>Agc	p.G152S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTGGATCCTGGGCTCTATGGA	0.468000													50	479					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54812814	54812814	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:54812814C>G	ENST00000293379.4	-	1	430	c.169G>C	c.(169-171)Ggc>Cgc	p.G57R	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	57					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AAGAAGGAGCCCGGGGGCCCC	0.687000													7	46					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75602909	75602909	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:75602909G>T	ENST00000294638.5	+	4	894	c.230G>T	c.(229-231)aGt>aTt	p.S77I	LHX8_ENST00000559413.1_3'UTR|LHX8_ENST00000356261.3_Missense_Mutation_p.S67I	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	77	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						GTGTGCAACAGTTGCGGCCTG	0.662000													5	36					0.000602214	0.000612336	1	1	0
FNDC8	54752	broad.mit.edu	37	17	33454292	33454292	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr17:33454292G>A	ENST00000158009.5	+	2	556	c.441G>A	c.(439-441)caG>caA	p.Q147Q		NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	147										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		CGAAGTCCCAGATGGCCACAA	0.582000													30	195					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2817994	2817994	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr16:2817994G>A	ENST00000301740.8	+	11	8014	c.7465G>A	c.(7465-7467)Gat>Aat	p.D2489N	SRRM2_ENST00000574593.1_3'UTR	NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2489	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CTCTGCTGGTGATCACAATGG	0.607000													9	76					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59520336	59520336	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:59520336T>C	ENST00000038176.3	-	11	963	c.751A>G	c.(751-753)Atg>Gtg	p.M251V	NSMAF_ENST00000427130.2_Missense_Mutation_p.M282V|NSMAF_ENST00000519858.1_5'UTR	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	251					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				ACCAGAGGCATGAGGCCGTGC	0.458000													18	121					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33263385	33263385	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:33263385C>G	ENST00000373477.4	-	5	1478	c.570G>C	c.(568-570)aaG>aaC	p.K190N		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	190					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	AGGTGAAAATCTTTCTCTGAT	0.383000													20	99					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	66879131	66879131	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr13:66879131C>T	ENST00000544246.1	-	5	4061	c.3370G>A	c.(3370-3372)Gaa>Aaa	p.E1124K	PCDH9_ENST00000377865.2_Missense_Mutation_p.E1124K|PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000328454.5_Missense_Mutation_p.E1090K|PCDH9_ENST00000456367.1_Missense_Mutation_p.E1090K	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1124					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCTGTAGCTTCAGCTAATCCT	0.438000													10	66					0	0	1	0	0
RNH1	6050	broad.mit.edu	37	11	498031	498031	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr11:498031G>A	ENST00000534797.1	-	7	2474	c.1067C>T	c.(1066-1068)gCg>gTg	p.A356V	RNH1_ENST00000533410.1_Missense_Mutation_p.A356V|RNH1_ENST00000397604.3_Missense_Mutation_p.A356V|RNH1_ENST00000397614.1_Missense_Mutation_p.A356V|RNH1_ENST00000397615.2_Missense_Mutation_p.A356V|RNH1_ENST00000356187.5_Missense_Mutation_p.A356V|RNH1_ENST00000354420.2_Missense_Mutation_p.A356V|RNH1_ENST00000438658.2_Missense_Mutation_p.A356V			P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor 1	356					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGCACGCCCGCATCCTCCAG	0.612000													4	97					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43907989	43907989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:43907989C>T	ENST00000562955.1	+	56	7753	c.7753C>T	c.(7753-7755)Cga>Tga	p.R2585*	SZT2_ENST00000372442.1_Nonsense_Mutation_p.R1743*	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2642						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GAGCTCAGGGCGAAATGCTCC	0.602000													4	29					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17439147	17439147	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:17439147C>A	ENST00000159087.4	-	13	2208	c.2050G>T	c.(2050-2052)Ggc>Tgc	p.G684C		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	684						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						CGGCCCTCGCCCCCGGCCCGG	0.741000													3	6					1	1	1	1	0
PKD1	5310	broad.mit.edu	37	16	2159887	2159887	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr16:2159887C>T	ENST00000262304.4	-	15	5489	c.5281G>A	c.(5281-5283)Gag>Aag	p.E1761K	PKD1_ENST00000423118.1_Missense_Mutation_p.E1761K	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1761	PKD 13.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCGGAGGTCTCCCAGCTCAGC	0.632000													7	40					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869477	36869477	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:36869477G>A	ENST00000279024.4	-	3	1327	c.1056C>T	c.(1054-1056)ttC>ttT	p.F352F		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	352										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CCTTTCTCCTGAAGCCCAAAT	0.527000													42	336					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487607	131487607	+	Missense_Mutation	SNP	G	G	A	rs76455422		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:131487607G>A	ENST00000309926.4	+	1	965	c.883G>A	c.(883-885)Ggg>Agg	p.G295R		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	295						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					CATTGACTCTGGGACTCACAC	0.562000													10	89					0	0	1	0	0
TRIM13	10206	broad.mit.edu	37	13	50586862	50586862	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr13:50586862C>G	ENST00000378182.3	+	2	1524	c.786C>G	c.(784-786)atC>atG	p.I262M	TRIM13_ENST00000298772.5_Missense_Mutation_p.I265M|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000420995.2_Missense_Mutation_p.I262M|TRIM13_ENST00000356017.4_Missense_Mutation_p.I265M|TRIM13_ENST00000457662.2_Missense_Mutation_p.I262M	NM_001007278.1|NM_005798.3|NM_052811.2|NM_213590.1	NP_001007279.1|NP_005789.2|NP_434698.1|NP_998755.1	O60858	TRI13_HUMAN	tripartite motif containing 13	262					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		TCAAAGTAATCAAGGAAACTC	0.403000													24	90					0	0	1	0	0
NCBP2	22916	broad.mit.edu	37	3	196669324	196669324	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:196669324C>T	ENST00000321256.5	-	1	144	c.51G>A	c.(49-51)ctG>ctA	p.L17L	NCBP2-AS1_ENST00000447775.1_RNA|NCBP2_ENST00000427641.2_Silent_p.L17L	NM_007362.3	NP_031388.2	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	17					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		GGTACTGGCTCAGCTCCACGT	0.652000											OREG0016012	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	23					0	0	1	0	0
NOB1	28987	broad.mit.edu	37	16	69783174	69783174	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr16:69783174G>C	ENST00000268802.5	-	5	496	c.467C>G	c.(466-468)tCc>tGc	p.S156C		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	156						nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GAACATGAAGGAACTAAATTC	0.438000													16	116					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													5	30					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769807	50769807	+	Silent	SNP	G	G	A	rs143459892		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:50769807G>A	ENST00000216923.4	-	6	1273	c.924C>T	c.(922-924)atC>atT	p.I308I	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Silent_p.I254I|ZFP64_ENST00000371515.4_Silent_p.I306I	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						CGCTGTGCTTGATACGGATGT	0.572000													14	111					0	0	1	0	0
ORAI1	84876	broad.mit.edu	37	12	122079387	122079387	+	Silent	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:122079387G>C	ENST00000330079.7	+	2	943	c.750G>C	c.(748-750)ctG>ctC	p.L250L		NM_032790.3	NP_116179.2	Q96D31	CRCM1_HUMAN	ORAI calcium release-activated calcium modulator 1	248					platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		CCTTCGGCCTGATCTTTATCG	0.632000													22	79					0	0	1	0	0
NBPF18P	441908	broad.mit.edu	37	1	151992794	151992794	+	RNA	SNP	T	T	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:151992794T>C	ENST00000432386.1	+	0	2459					NR_103561.1																						GCAGAGCAGCTTGGGCAAGCT	0.527000													57	145					0	0	1	0	0
CEP55	55165	broad.mit.edu	37	10	95276763	95276763	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:95276763G>A	ENST00000371485.3	+	6	1055	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	251					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				TCTTGAGGTTGAACGACAAAC	0.358000													11	92					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35991318	35991318	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr5:35991318G>A	ENST00000274278.3	-	1	382	c.25C>T	c.(25-27)Cta>Tta	p.L9L	UGT3A1_ENST00000333811.4_Intron|UGT3A1_ENST00000503189.1_Silent_p.L9L|UGT3A1_ENST00000513233.1_5'UTR|UGT3A1_ENST00000507113.1_Silent_p.L9L	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	9						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGGCCACTAGAAGCAGCACC	0.602000													21	151					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125455922	125455922	+	Missense_Mutation	SNP	C	C	T	rs139345740		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:125455922C>T	ENST00000308736.2	-	8	1215	c.1117G>A	c.(1117-1119)Gag>Aag	p.E373K	DHX37_ENST00000544745.1_Missense_Mutation_p.E160K	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	373	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TCGTGGGCCTCGTCGATGATC	0.657000													4	34					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307214	46307214	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:46307214G>C	ENST00000357422.2	+	4	1108	c.565G>C	c.(565-567)Gag>Cag	p.E189Q	CCR3_ENST00000541018.1_Missense_Mutation_p.E189Q|CCR3_ENST00000395940.2_Missense_Mutation_p.E189Q|CCR3_ENST00000395942.2_Missense_Mutation_p.E189Q|CCR3_ENST00000545097.1_Missense_Mutation_p.E210Q			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	189					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		TCTTTACCCAGAGGATACAGT	0.478000													15	98					0	0	1	0	0
GOLGA7B	401647	broad.mit.edu	37	10	99623815	99623815	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:99623815C>G	ENST00000370602.1	+	3	332	c.267C>G	c.(265-267)ctC>ctG	p.L89L		NM_001010917.2	NP_001010917.1	Q2TAP0	GOG7B_HUMAN	golgin A7 family, member B	89						Golgi membrane				endometrium(1)|large_intestine(3)|prostate(1)	5						TCATCTTCCTCTGCATGGAGA	0.617000													8	84					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9203973	9203973	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:9203973C>G	ENST00000429566.3	+	1	119	c.53C>G	c.(52-54)tCa>tGa	p.S18*		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CTGGGACTCTCAGAAAAGCCA	0.498000													11	77					0	0	1	0	0
POLB	5423	broad.mit.edu	37	8	42229169	42229169	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:42229169C>T	ENST00000265421.4	+	14	1172	c.1002C>T	c.(1000-1002)agC>agT	p.S334S	POLB_ENST00000538005.1_Silent_p.S180S|POLB_ENST00000521492.1_Silent_p.S53S	NM_002690.2	NP_002681.1	P06746	DPOLB_HUMAN	polymerase (DNA directed), beta	334					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	16	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	AGGACCGGAGCGAATGAGGCC	0.448000								DNA polymerases (catalytic subunits)					4	44					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5445209	5445209	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr17:5445209C>G	ENST00000345221.3	-	6	3221	c.2667G>C	c.(2665-2667)ctG>ctC	p.L889L	NLRP1_ENST00000269280.4_Silent_p.L889L|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Silent_p.L889L|NLRP1_ENST00000577119.1_Silent_p.L889L|NLRP1_ENST00000572272.1_Silent_p.L889L|NLRP1_ENST00000262467.5_Silent_p.L889L	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	889					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TCGGCTGTCTCAGTCTCTGGC	0.587000													5	59					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60587884	60587884	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:60587884G>A	ENST00000252996.3	-	3	1627	c.1628C>T	c.(1627-1629)tCg>tTg	p.S543L		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	543					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GACGCCGGGCGAGCGCTGCAG	0.577000													20	128					0	0	1	0	0
C5orf38	153571	broad.mit.edu	37	5	2755183	2755183	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr5:2755183C>T	ENST00000397835.4	+	3	374	c.374C>T	c.(373-375)tCa>tTa	p.S125L	C5orf38_ENST00000334000.3_3'UTR|C5orf38_ENST00000457752.2_3'UTR|C5orf38_ENST00000505778.1_3'UTR			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	0						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		ACGCAAGTTTCAGCGAGCGGG	0.582000													16	208					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111666438	111666438	+	Silent	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:111666438G>A	ENST00000389811.4	+	11	1085	c.861G>A	c.(859-861)ctG>ctA	p.L287L	ACOXL_ENST00000439055.1_Silent_p.L287L			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	287					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CCCTGCGGCTGATGCCCCACC	0.547000													12	120					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753367	18753367	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:18753367G>A	ENST00000380548.4	+	16	2417	c.2078G>A	c.(2077-2079)tGc>tAc	p.C693Y		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	693	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GACGTCTTCTGCAGCCACCTG	0.532000													7	18					0	0	1	0	0
ACP6	51205	broad.mit.edu	37	1	147124425	147124425	+	Missense_Mutation	SNP	T	T	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:147124425T>G	ENST00000392988.2	-	7	999	c.806A>C	c.(805-807)cAt>cCt	p.H269P	ACP6_ENST00000369238.5_Intron			Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	0					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					TCAGCTTCCATGGAACCTGCA	0.483000													10	71					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261731	39261731	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr17:39261731G>C	ENST00000391415.1	+	1	148	c.91G>C	c.(91-93)Gag>Cag	p.E31Q		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	31	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament		p.E31Q(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						CAGCTGCTGTGAGACCACCTG	0.637000													4	69					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98808826	98808826	+	Missense_Mutation	SNP	C	C	T	rs140404931	byFrequency	TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:98808826C>T	ENST00000266058.4	-	14	1596	c.1351G>A	c.(1351-1353)Gca>Aca	p.A451T	SLIT1_ENST00000371070.4_Missense_Mutation_p.A451T|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	451	LRRCT 2.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGGAAGTCTGCCAGCCACTTG	0.592000													4	80					0	0	1	0	0
C3orf18	51161	broad.mit.edu	37	3	50602922	50602922	+	Missense_Mutation	SNP	G	G	A	rs113250784		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:50602922G>A	ENST00000357203.3	-	3	748	c.209C>T	c.(208-210)aCg>aTg	p.T70M	C3orf18_ENST00000449241.1_Missense_Mutation_p.T70M|C3orf18_ENST00000426034.1_Missense_Mutation_p.T70M|C3orf18_ENST00000441239.1_Intron|C3orf18_ENST00000486175.1_Intron	NM_016210.4	NP_057294.2	Q9UK00	CC018_HUMAN	chromosome 3 open reading frame 18	70						integral to membrane		p.T70M(1)		lung(1)|pancreas(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		GCCTATCACCGTGATGATCCC	0.532000													9	28					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167750483	167750483	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:167750483T>C	ENST00000470487.1	-	9	1690	c.1001A>G	c.(1000-1002)cAg>cGg	p.Q334R	GOLIM4_ENST00000309027.4_Missense_Mutation_p.Q306R	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	334	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTCTTCCACCTGATGCTCCTC	0.537000													4	128					0	0	1	0	0
FKBP11	51303	broad.mit.edu	37	12	49318025	49318025	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:49318025G>C	ENST00000550765.1	-	4	696	c.298C>G	c.(298-300)Ctt>Gtt	p.L100V	CCDC65_ENST00000266984.5_Intron|FKBP11_ENST00000453172.2_Missense_Mutation_p.L100V|FKBP11_ENST00000444214.2_5'UTR|ARF3_ENST00000398092.4_Intron|FKBP11_ENST00000552878.1_Missense_Mutation_p.L100V|AC073610.5_ENST00000537495.1_Intron	NM_016594.2	NP_057678.1	Q9NYL4	FKB11_HUMAN	FK506 binding protein 11, 19 kDa	100	PPIase FKBP-type.				protein folding	integral to membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			kidney(1)|large_intestine(3)|lung(1)	5						ATGTCGAGAAGACTCTGCTCC	0.527000													5	28					0	0	1	0	0
SPATA6	54558	broad.mit.edu	37	1	48825437	48825437	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:48825437G>C	ENST00000371847.3	-	10	1079	c.915C>G	c.(913-915)atC>atG	p.I305M	SPATA6_ENST00000396199.3_Missense_Mutation_p.I233M|SPATA6_ENST00000371843.3_Missense_Mutation_p.I305M	NM_019073.2	NP_061946.1	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6	305					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				breast(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	21						GGGGTGTCCTGATAACCTGTT	0.348000													8	54					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3163005	3163005	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:3163005C>G	ENST00000262958.3	+	7	1371	c.1113C>G	c.(1111-1113)atC>atG	p.I371M		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	371					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TGGACGAGATCAACCTGCTGT	0.652000											OREG0025150	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	38					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2775763	2775763	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr18:2775763G>C	ENST00000320876.6	+	42	5545	c.5207G>C	c.(5206-5208)aGa>aCa	p.R1736T	SMCHD1_ENST00000261598.8_Missense_Mutation_p.R1736T|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1736					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GAAGATGATAGAGCTGCGATG	0.353000													28	81					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													3	8					0	0	1	0	0
HARBI1	283254	broad.mit.edu	37	11	46625092	46625092	+	Silent	SNP	A	A	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr11:46625092A>G	ENST00000326737.3	-	3	1285	c.1038T>C	c.(1036-1038)acT>acC	p.T346T		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	346						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						AGCTAAAATGAGTGAGCATTA	0.493000													14	93					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782741	55782741	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr10:55782741C>T	ENST00000373965.2	-	20	2852	c.2458G>A	c.(2458-2460)Gat>Aat	p.D820N	PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.D791N|PCDH15_ENST00000414778.1_Missense_Mutation_p.D818N|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.D742N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.D776N|PCDH15_ENST00000409834.1_Missense_Mutation_p.D424N|PCDH15_ENST00000395445.1_Missense_Mutation_p.D820N|PCDH15_ENST00000373955.1_Missense_Mutation_p.D813N|PCDH15_ENST00000395438.1_Missense_Mutation_p.D813N|PCDH15_ENST00000361849.3_Missense_Mutation_p.D813N|PCDH15_ENST00000395430.1_Missense_Mutation_p.D813N|PCDH15_ENST00000320301.6_Missense_Mutation_p.D813N	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	813	Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGTTATCATCAATGTCCAAA	0.443000										HNSCC(58;0.16)			22	146					0	0	1	0	0
EML2	24139	broad.mit.edu	37	19	46133232	46133232	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:46133232C>G	ENST00000536630.1	-	10	1162	c.1024G>C	c.(1024-1026)Gag>Cag	p.E342Q	EML2_ENST00000586902.1_5'UTR|EML2_ENST00000589876.1_Missense_Mutation_p.E195Q|EML2_ENST00000245925.3_Missense_Mutation_p.E195Q|EML2_ENST00000587152.1_Missense_Mutation_p.E396Q	NM_001193269.1	NP_001180198.1	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like 2	195					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		ACCTTGGTCTCCTTGGCCCAG	0.547000													5	49					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	112635	112635	+	Missense_Mutation	SNP	G	G	A	rs143220179		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr16:112635G>A	ENST00000262316.6	-	7	996	c.854C>T	c.(853-855)tCg>tTg	p.S285L	RHBDF1_ENST00000454039.2_Missense_Mutation_p.S285L	NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	285					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				CGCTGCCTCCGATGGGGACTC	0.617000													31	284					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63928252	63928252	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr15:63928252C>A	ENST00000443617.2	-	65	12409	c.12322G>T	c.(12322-12324)Gat>Tat	p.D4108Y		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4108					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TAGTCACCATCTCCCCAGCTA	0.557000													44	237					1.57945e-13	1.7374e-13	1	1	0
KANSL1L	151050	broad.mit.edu	37	2	211018364	211018364	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:211018364G>A	ENST00000281772.9	-	2	1206	c.943C>T	c.(943-945)Cgg>Tgg	p.R315W	KANSL1L_ENST00000418791.1_Missense_Mutation_p.R315W|KANSL1L_ENST00000452086.1_Missense_Mutation_p.R315W|KANSL1L_ENST00000457374.1_Missense_Mutation_p.R315W	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	315																	GCTGTACACCGTGCAAAGCCA	0.413000													7	220					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730676	37730676	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr8:37730676C>T	ENST00000330843.4	-	4	1656	c.1644G>A	c.(1642-1644)gcG>gcA	p.A548A	RAB11FIP1_ENST00000523182.1_5'UTR|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000524118.1_Intron	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	548					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTGTGGGTTGCGCCTCTGGAG	0.502000													13	85					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554339	85554339	+	Silent	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr2:85554339C>T	ENST00000377386.3	-	2	978	c.516G>A	c.(514-516)gcG>gcA	p.A172A	TGOLN2_ENST00000444342.2_Silent_p.A172A|TGOLN2_ENST00000282120.2_Silent_p.A74A|TGOLN2_ENST00000409015.1_Silent_p.A172A|TGOLN2_ENST00000398263.2_Silent_p.A172A|TGOLN2_ENST00000409232.3_Silent_p.A172A			O43493	TGON2_HUMAN	trans-golgi network protein 2	172	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										TTGTGGTCTGCGCCTCCGAAC	0.602000													7	861					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104703816	104703816	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr7:104703816C>T	ENST00000334877.4	+	5	739	c.205C>T	c.(205-207)Cgt>Tgt	p.R69C	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000476671.1_Missense_Mutation_p.R69C|KMT2E_ENST00000311117.3_Missense_Mutation_p.R69C|KMT2E_ENST00000257745.4_Missense_Mutation_p.R69C					lysine (K)-specific methyltransferase 2E																		TTATGGTGCTCGTCCTCCTCC	0.353000													8	61					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14288488	14288488	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr19:14288488C>T	ENST00000340736.6	-	3	436	c.139G>A	c.(139-141)Gag>Aag	p.E47K	LPHN1_ENST00000361434.3_Missense_Mutation_p.E47K	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	47	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CACCGCAGCTCGATGGGGTAG	0.647000													36	111					0	0	1	0	0
LOC102723924	102723924	broad.mit.edu	37	1	41730645	41730645	+	RNA	DEL	T	T	-	rs35691145		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:41730645delT	ENST00000445073.1	+	0	132																											TCTGAGCTGCttttttttttt	0.473													3	4	---	---	---	---					
CDC7	8317	broad.mit.edu	37	1	91967356	91967357	+	Frame_Shift_Ins	INS	-	-	A			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr1:91967356_91967357insA	ENST00000428239.1	+	2	342_343	c.83_84insA	c.(82-84)taafs	p.*28fs	CDC7_ENST00000234626.6_Frame_Shift_Ins_p.*28fs|CDC7_ENST00000430031.2_Frame_Shift_Ins_p.*28fs|CDC7_ENST00000497611.1_3'UTR	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	28					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GAAGGCTCTTTAAAAAAAAACG	0.406													7	163	---	---	---	---					
CDC25A	993	broad.mit.edu	37	3	48200922	48200923	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr3:48200922_48200923delTC	ENST00000302506.3	-	14	1753_1754	c.1345_1346delGA	c.(1345-1347)tfs	p.D449fs	CDC25A_ENST00000351231.3_Frame_Shift_Del_p.D409fs	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	449	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACCCAGGCGATCTCTCTCTCTC	0.515													7	125	---	---	---	---					
FOXB2	442425	broad.mit.edu	37	9	79635062	79635064	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr9:79635062_79635064delGCC	ENST00000376708.1	+	1	492_494	c.492_494delGCC	c.(490-495)cag>ca	p.QP164del		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	164	Poly-Pro.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						accCACCCCAgccgccgccgccg	0.704													3	6	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	75994146	75994146	+	RNA	DEL	G	G	-			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr12:75994146delG	ENST00000552856.1	-	0	549																											TCTGAATATAGGGATGACACA	0.408													2	4	---	---	---	---					
SRP54-AS1	100506157	broad.mit.edu	37	14	35390295	35390296	+	RNA	INS	-	-	T	rs113610910		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr14:35390295_35390296insT	ENST00000556355.1	-	0	524																											CACATATTGCAttttttttttt	0.436													3	3	---	---	---	---					
B2M	567	broad.mit.edu	37	15	45007773	45007773	+	Frame_Shift_Del	DEL	T	T	-			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr15:45007773delT	ENST00000558401.1	+	2	290	c.220delT	c.(220-222)tgfs	p.L74fs	B2M_ENST00000559220.1_Intron|B2M_ENST00000544417.1_Frame_Shift_Del_p.L74fs|B2M_ENST00000559916.1_Frame_Shift_Del_p.L74fs	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	74	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.K61_L74del(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GCATTCAGACTTGTCTTTCAG	0.413													19	132	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													5	8	---	---	---	---					
HRH3	11255	broad.mit.edu	37	20	60791100	60791100	+	Frame_Shift_Del	DEL	T	T	-			TCGA-H7-A76A-01A-51D-A34J-08	TCGA-H7-A76A-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d784bd4-0097-4aff-8e09-d29159fc0d46	b902c50b-2be0-45db-b315-afc7a2e5cb77	g.chr20:60791100delT	ENST00000340177.5	-	3	1584	c.1300delA	c.(1300-1302)tcfs	p.I434fs	HRH3_ENST00000317393.6_Frame_Shift_Del_p.I434fs	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	434					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TGGGGCTGGATTTTGAGCTTC	0.647													2	4	---	---	---	---