Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GATA3	2625	broad.mit.edu	37	10	8100451	8100451	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr10:8100451C>T	ENST00000379328.3	+	3	993	c.425C>T	c.(424-426)tCg>tTg	p.S142L	GATA3_ENST00000346208.3_Missense_Mutation_p.S142L|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	142	Poly-Ser.				aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TCCTCCTTGTCGGGGGGCCAC	0.726000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						33	107					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477018	128477018	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:128477018G>T	ENST00000322313.4	-	16	2739	c.2581C>A	c.(2581-2583)Cag>Aag	p.Q861K		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	861					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGCCCCTGCTGACTTTGTGAG	0.652000													20	102					2.94398e-08	3.05169e-08	1	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119133024	119133024	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr3:119133024G>A	ENST00000264245.4	+	12	2780	c.2248G>A	c.(2248-2250)Gcc>Acc	p.A750T		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	750	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity	p.A750T(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CCCAGACCTCGCCAGCCTGGC	0.592000													11	128					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42713545	42713545	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr5:42713545T>C	ENST00000230882.4	+	8	989	c.799T>C	c.(799-801)Tgg>Cgg	p.W267R	GHR_ENST00000357703.3_Missense_Mutation_p.W245R|GHR_ENST00000537449.1_Missense_Mutation_p.W80R	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	267					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CTACTTTCCATGGCTCTTAAT	0.323000													6	69					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32715162	32715162	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:32715162G>A	ENST00000421745.2	+	43	8284	c.8150G>A	c.(8149-8151)cGg>cAg	p.R2717Q		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2717					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ACTTTGCTCCGGACATGGTGC	0.343000													4	161					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27950551	27950551	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr9:27950551G>T	ENST00000379992.2	-	6	568	c.119C>A	c.(118-120)tCt>tAt	p.S40Y	LINGO2_ENST00000308675.3_Missense_Mutation_p.S40Y	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	40	LRRNT.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		ACAGCTAACAGATTTGTTCTG	0.517000													21	97					1.10513e-12	1.15971e-12	1	1	0
NUP85	79902	broad.mit.edu	37	17	73230760	73230760	+	Silent	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:73230760C>T	ENST00000447371.2	+	16	1564	c.1140C>T	c.(1138-1140)taC>taT	p.Y380Y	NUP85_ENST00000541827.1_Silent_p.Y502Y|NUP85_ENST00000579298.1_Silent_p.Y503Y|NUP85_ENST00000245544.4_Silent_p.Y548Y|NUP85_ENST00000540768.1_Silent_p.Y151Y|NUP85_ENST00000579324.1_Silent_p.Y436Y			Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	548					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			ACCGTATGTACGGGGAGAAGC	0.517000													5	274					0	0	1	0	0
ZNF25	219749	broad.mit.edu	37	10	38241241	38241241	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr10:38241241C>G	ENST00000302609.7	-	6	1397	c.1185G>C	c.(1183-1185)gaG>gaC	p.E395D	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				CATAGGGCTTCTCTCCTGTGT	0.438000													4	80					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895339	42895339	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr4:42895339G>A	ENST00000399770.2	+	1	56	c.56G>A	c.(55-57)cGg>cAg	p.R19Q		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	19					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						GTCCGGTTTCGGATCGCGTCC	0.512000													22	138					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114184787	114184787	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:114184787G>A	ENST00000369615.1	+	10	1677	c.1615G>A	c.(1615-1617)Gag>Aag	p.E539K	MAGI3_ENST00000369617.4_Missense_Mutation_p.E564K|MAGI3_ENST00000307546.9_Missense_Mutation_p.E539K|MAGI3_ENST00000369611.4_Missense_Mutation_p.E539K	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	564					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATGGTTCTGGAGCAGAATGG	0.488000													7	124					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1262965	1262965	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr10:1262965G>C	ENST00000381312.1	-	7	1933	c.1608C>G	c.(1606-1608)agC>agG	p.S536R	ADARB2_ENST00000469464.1_5'UTR	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	536	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		TCTGCACTGCGCTGGGGCCAC	0.662000													5	26					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78917350	78917350	+	Missense_Mutation	SNP	T	T	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr15:78917350T>G	ENST00000412074.2	-	5	754	c.643A>C	c.(643-645)Acc>Ccc	p.T215P	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CTGTGGCTGGTTTGATGGGGT	0.572000													7	26					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113684607	113684607	+	Splice_Site	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr11:113684607C>T	ENST00000003302.4	-	15	1811	c.1743_splice	c.e15+1	p.Q581_splice	USP28_ENST00000260188.5_Splice_Site_p.Q581_splice|USP28_ENST00000545540.1_Splice_Site_p.Q456_splice|USP28_ENST00000544967.1_Splice_Site_p.Q289_splice|USP28_ENST00000537706.1_Silent_p.Q581Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	581					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TTCATTCTACCTGACGAAGGA	0.358000													3	23					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2472309	2472309	+	Missense_Mutation	SNP	T	T	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr7:2472309T>G	ENST00000258711.6	+	2	170	c.35T>G	c.(34-36)gTg>gGg	p.V12G		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	12					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding	p.V12G(2)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTGTGGCTGGTGCTGGGGTCG	0.662000													7	46					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43474296	43474296	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:43474296G>A	ENST00000532038.1	-	10	1406	c.1271C>T	c.(1270-1272)gCg>gTg	p.A424V	ARHGAP27_ENST00000376922.2_Missense_Mutation_p.A305V|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.A619V|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.A646V|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.A624V|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.A278V|ARHGAP27_ENST00000455881.1_Missense_Mutation_p.A305V			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	646	WW 3.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					ATTCGGTCGCGCGTCCTCCTC	0.677000													26	59					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195507062	195507062	+	Missense_Mutation	SNP	C	C	T	rs74208457		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr3:195507062C>T	ENST00000463781.3	-	2	11848	c.11389G>A	c.(11389-11391)Gac>Aac	p.D3797N	MUC4_ENST00000475231.1_Missense_Mutation_p.D3797N|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	580					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGTGTCGGTGACAGGA	0.607000													2	2					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98058845	98058845	+	Missense_Mutation	SNP	G	G	A	rs143154602		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:98058845G>A	ENST00000370192.3	-	10	1157	c.1057C>T	c.(1057-1059)Cgt>Tgt	p.R353C		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	353					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCTCCACAACGTAGAGCAGAT	0.483000													30	89					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36691743	36691743	+	Silent	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:36691743C>T	ENST00000280527.2	+	5	1303	c.936C>T	c.(934-936)gtC>gtT	p.V312V		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	312					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CCCGCATAGTCTCTCGTGGCG	0.498000													51	197					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11593460	11593460	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:11593460C>A	ENST00000262442.3	+	20	4389	c.4321C>A	c.(4321-4323)Cag>Aag	p.Q1441K	DNAH9_ENST00000454412.2_Missense_Mutation_p.Q1441K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1441	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAAGGAGCTGCAGACTACCTG	0.552000													6	43					0.217242	0.217242	1	1	0
WBP11	51729	broad.mit.edu	37	12	14947617	14947617	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:14947617C>T	ENST00000261167.2	-	7	808	c.575G>A	c.(574-576)cGt>cAt	p.R192H	WBP11_ENST00000537574.1_Missense_Mutation_p.R192H	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	192	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						AGGGGGCAAACGTGGAACACC	0.488000													33	144					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64968932	64968932	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr10:64968932G>A	ENST00000399262.2	-	9	2976	c.2758C>T	c.(2758-2760)Ctt>Ttt	p.L920F	JMJD1C_ENST00000542921.1_Missense_Mutation_p.L738F|JMJD1C_ENST00000402544.1_Missense_Mutation_p.L701F|JMJD1C_ENST00000399251.1_Missense_Mutation_p.L701F	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	920					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATGTGACTAAGTAATCCAATA	0.423000													13	74					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													4	65					0	0	1	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13399965	13399965	+	Missense_Mutation	SNP	A	A	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:13399965A>G	ENST00000284110.1	-	2	1567	c.770T>C	c.(769-771)cTg>cCg	p.L257P	HS3ST3A1_ENST00000578576.1_Missense_Mutation_p.L55P	NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	257						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCGCTTGGACAGCGTCTGCGT	0.642000													7	94					0	0	1	0	0
IRF1	3659	broad.mit.edu	37	5	131822820	131822820	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr5:131822820G>A	ENST00000245414.4	-	4	448	c.190C>T	c.(190-192)Cga>Tga	p.R64*	IRF1_ENST00000463784.1_5'UTR|IRF1_ENST00000405885.2_Nonsense_Mutation_p.R64*	NM_002198.2	NP_002189.1	P10914	IRF1_HUMAN	interferon regulatory factor 1	64					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GCTTTGTATCGGCCTAGAGGG	0.567000													6	325					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220409504	220409504	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:220409504G>A	ENST00000344458.2	+	3	640	c.55G>A	c.(55-57)Gat>Aat	p.D19N	TMEM198_ENST00000373883.3_Missense_Mutation_p.D19N			Q66K66	TM198_HUMAN	transmembrane protein 198	19						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGAGCCAGATGATGCCTTCTG	0.592000													5	98					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179322747	179322747	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:179322747C>T	ENST00000367619.3	+	16	1767	c.1624C>T	c.(1624-1626)Cgt>Tgt	p.R542C	SOAT1_ENST00000539888.1_Missense_Mutation_p.R477C|SOAT1_ENST00000540564.1_Missense_Mutation_p.R484C|SOAT1_ENST00000535686.1_Missense_Mutation_p.R278C	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	542					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	TGTCCGGCCACGTTCCTGGAC	0.458000													4	149					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5461873	5461873	+	Missense_Mutation	SNP	A	A	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr4:5461873A>G	ENST00000282908.5	+	9	1249	c.827A>G	c.(826-828)gAc>gGc	p.D276G	STK32B_ENST00000510398.1_Missense_Mutation_p.D229G|STK32B_ENST00000508728.1_3'UTR|STK32B_ENST00000512636.1_Missense_Mutation_p.D199G	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	276	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						AGCCTTCATGACATACAGAGC	0.562000											OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	80					0	0	1	0	0
XPO1	7514	broad.mit.edu	37	2	61715378	61715378	+	Missense_Mutation	SNP	A	A	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:61715378A>C	ENST00000401558.2	-	19	2962	c.2235T>G	c.(2233-2235)atT>atG	p.I745M	XPO1_ENST00000406957.1_Missense_Mutation_p.I745M|XPO1_ENST00000404992.2_Missense_Mutation_p.I745M	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	745					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			GCATACTTCTAATCAATGGTT	0.363000			Mis		CLL								21	83					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17296411	17296411	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:17296411G>A	ENST00000375541.5	+	33	5502	c.5433G>A	c.(5431-5433)caG>caA	p.Q1811Q		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1811					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCGAGGGCCAGCTACAACAGC	0.662000													11	65					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135369153	135369153	+	Missense_Mutation	SNP	G	G	A	rs143005509		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr10:135369153G>A	ENST00000368517.3	-	11	808	c.670C>T	c.(670-672)Cgc>Tgc	p.R224C	SYCE1_ENST00000432597.2_Missense_Mutation_p.R224C|SYCE1_ENST00000343131.5_Missense_Mutation_p.R260C|SPRN_ENST00000541506.1_Intron	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	260					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		tgctggtggcgctgggcagca	0.652000													12	51					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397652	125397652	+	Silent	SNP	T	T	C	rs146795524		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:125397652T>C	ENST00000536769.1	-	1	2242	c.666A>G	c.(664-666)gtA>gtG	p.V222V	UBC_ENST00000546120.1_Silent_p.V146V|UBC_ENST00000339647.5_Silent_p.V222V|UBC_ENST00000538617.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	222	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGACGGAGTACCAGGTGCA	0.512000													4	151					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121930093	121930093	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr9:121930093G>A	ENST00000265922.3	-	8	2016	c.1555C>T	c.(1555-1557)Cgg>Tgg	p.R519W	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		519					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TTGCGCCACCGAGGGTCAAAG	0.567000													8	66					0	0	1	0	0
ORC2	4999	broad.mit.edu	37	2	201791609	201791609	+	Missense_Mutation	SNP	A	A	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:201791609A>C	ENST00000234296.2	-	12	1181	c.932T>G	c.(931-933)aTt>aGt	p.I311S		NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	311					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						ATAAAGCACAATGTTGAACCC	0.358000													19	77					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1558985	1558985	+	Splice_Site	SNP	G	G	A	rs140632398	by1000genomes	TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr20:1558985G>A	ENST00000381605.4	-	2	496	c.433_splice	c.e2+1	p.R144_splice	SIRPB1_ENST00000262929.5_Splice_Site_p.R143_splice|RP4-576H24.4_ENST00000564763.1_Splice_Site_p.R144_splice|SIRPB1_ENST00000381603.3_Splice_Site_p.R144_splice	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	144					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						TGTACTCACCGCGCACAGACA	0.552000													4	160					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676716	100676716	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr7:100676716G>A	ENST00000306151.4	+	3	2083	c.2019G>A	c.(2017-2019)gcG>gcA	p.A673A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	673	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTACAACTGCGGAAGGTACCA	0.498000													6	733					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126052082	126052082	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr8:126052082C>T	ENST00000318410.7	-	24	3258	c.2909G>A	c.(2908-2910)cGg>cAg	p.R970Q	KIAA0196_ENST00000517845.1_Missense_Mutation_p.R822Q	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	970					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGAATCAAACCGACAAGAATA	0.423000													3	48					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46622097	46622097	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:46622097G>A	ENST00000330070.4	-	1	1344	c.177C>T	c.(175-177)ggC>ggT	p.G59G	HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	59					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						GGGTGGAGGCGCCGGGCTGGA	0.637000													17	75					0	0	1	0	0
LHFPL5	222662	broad.mit.edu	37	6	35773525	35773525	+	Silent	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr6:35773525C>T	ENST00000360215.1	+	1	455	c.78C>T	c.(76-78)ggC>ggT	p.G26G	LHFPL5_ENST00000373853.1_Silent_p.G26G	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	26						integral to membrane				endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						GAGCCGTGGGCGTGATGTGGG	0.617000													43	171					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44122113	44122113	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr6:44122113G>A	ENST00000259746.9	+	23	2421	c.2238G>A	c.(2236-2238)acG>acA	p.T746T	TMEM63B_ENST00000323267.6_Silent_p.T746T			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	746						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			TTGAGCACACGGAGACAGATA	0.632000													13	91					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	48					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3429890	3429890	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr4:3429890G>A	ENST00000336727.3	+	15	4309	c.3405G>A	c.(3403-3405)tcG>tcA	p.S1135S	RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000306648.7_Silent_p.S533S|RGS12_ENST00000382788.3_Silent_p.S1135S|RGS12_ENST00000538395.1_Silent_p.S477S|RGS12_ENST00000344733.5_Silent_p.S1135S|RGS12_ENST00000338806.4_Silent_p.S487S	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1135						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAAACCACTCGGCTACGGTAA	0.562000													4	156					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047095	46047095	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr21:46047095G>A	ENST00000397911.3	+	1	56	c.7G>A	c.(7-9)Gcg>Acg	p.A3T	TSPEAR_ENST00000323084.4_Intron|KRTAP10-9_ENST00000484861.1_3'UTR	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	3						keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						CAGCATGGCCGCGTCCACCAT	0.627000													4	151					0	0	1	0	0
FOS	2353	broad.mit.edu	37	14	75745726	75745726	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr14:75745726C>T	ENST00000303562.4	+	1	250	c.41C>T	c.(40-42)tCc>tTc	p.S14F	FOS_ENST00000556324.2_3'UTR|FOS_ENST00000554617.1_Missense_Mutation_p.S14F|FOS_ENST00000535987.1_Missense_Mutation_p.S14F|FOS_ENST00000555242.1_Missense_Mutation_p.S14F	NM_005252.3	NP_005243.1	P01100	FOS_HUMAN	FBJ murine osteosarcoma viral oncogene homolog	14					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		GAGGCGTCATCCTCCCGCTGC	0.667000													5	50					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr9:21971186G>A	ENST00000304494.5	-	2	442	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P113L|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P72L|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P72L|RP11-145E5.5_ENST00000404796.2_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58			R -> Q (in dbSNP:rs36204273).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R58*(78)|p.?(45)|p.M53_R58del(3)|p.P113L(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*88(2)|p.0(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.P113fs*>61(1)|p.R58fs*62(1)|p.R58fs*61(1)|p.G55fs*86(1)|p.R58R(1)|p.A57fs*85(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	22					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	167					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71724933	71724933	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr11:71724933C>G	ENST00000393695.3	-	15	3947	c.3616G>C	c.(3616-3618)Gaa>Caa	p.E1206Q	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Missense_Mutation_p.E1206Q	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1206					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CACTCATCTTCAGCCTTGCTG	0.607000			T	RARA	APL								9	126					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:7578263G>A	ENST00000420246.2	-	6	718	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R196*|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	44					0	0	1	0	0
COQ4	51117	broad.mit.edu	37	9	131085368	131085368	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr9:131085368G>A	ENST00000300452.3	+	2	467	c.144G>A	c.(142-144)caG>caA	p.Q48Q	COQ4_ENST00000372875.3_Silent_p.Q48Q	NM_016035.3	NP_057119.2	Q9Y3A0	COQ4_HUMAN	coenzyme Q4	48					ubiquinone biosynthetic process	mitochondrial inner membrane				endometrium(4)|large_intestine(1)|lung(4)	9						CCCCGCTGCAGAAAGGGCTGT	0.716000													5	57					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49698888	49698888	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr6:49698888C>T	ENST00000433368.2	-	7	736	c.667G>A	c.(667-669)Gat>Aat	p.D223N	CRISP3_ENST00000393666.1_Missense_Mutation_p.D200N|CRISP3_ENST00000263045.4_Missense_Mutation_p.D213N|CRISP3_ENST00000371159.4_Missense_Mutation_p.D231N|CRISP3_ENST00000423399.2_Missense_Mutation_p.D110N	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	200					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CATAGTCCATCGTCACAGTTA	0.343000													6	41					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74572368	74572368	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr15:74572368G>C	ENST00000321288.5	+	10	1433	c.1433G>C	c.(1432-1434)cGa>cCa	p.R478P	CCDC33_ENST00000398814.3_Missense_Mutation_p.R275P			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	478							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TTCCAAGGCCGAGATGGAGCT	0.617000													3	43					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81719626	81719626	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:81719626C>T	ENST00000550584.2	-	21	2867	c.2572G>A	c.(2572-2574)Gca>Aca	p.A858T	PPFIA2_ENST00000407050.4_Missense_Mutation_p.A784T|PPFIA2_ENST00000549396.1_Missense_Mutation_p.A858T|PPFIA2_ENST00000541017.1_Missense_Mutation_p.A75T|PPFIA2_ENST00000548586.1_Missense_Mutation_p.A858T|PPFIA2_ENST00000541570.2_Missense_Mutation_p.A425T|PPFIA2_ENST00000443686.3_Missense_Mutation_p.A759T|PPFIA2_ENST00000549325.1_Missense_Mutation_p.A840T|PPFIA2_ENST00000333447.7_Missense_Mutation_p.A840T|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000552948.1_Missense_Mutation_p.A858T|PPFIA2_ENST00000550359.2_Missense_Mutation_p.A705T	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	784										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCCTGAGCTGCAGCTTCAGTC	0.423000													5	30					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9519164	9519164	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr2:9519164C>T	ENST00000281419.3	+	19	2264	c.1924C>T	c.(1924-1926)Cgg>Tgg	p.R642W	ASAP2_ENST00000315273.4_Missense_Mutation_p.R642W	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	642					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						GTTGCTCCTGCGGGGGAAGGC	0.652000													9	41					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23509593	23509593	+	Silent	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr5:23509593C>T	ENST00000296682.3	+	3	266	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	28	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AAGATGCCTTCAAAGACATTT	0.428000										HNSCC(3;0.000094)			33	168					0	0	1	0	0
ACSS2	55902	broad.mit.edu	37	20	33508832	33508832	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr20:33508832G>A	ENST00000360596.2	+	10	1378	c.1167G>A	c.(1165-1167)ccG>ccA	p.P389P	ACSS2_ENST00000336325.4_Silent_p.P339P|ACSS2_ENST00000253382.5_Silent_p.P402P|ACSS2_ENST00000476922.1_Intron	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	389					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCACATATCCGGACGTGAACC	0.507000													11	195					0	0	1	0	0
FEM1C	56929	broad.mit.edu	37	5	114878763	114878763	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr5:114878763T>C	ENST00000274457.3	-	2	989	c.428A>G	c.(427-429)gAa>gGa	p.E143G		NM_020177.2	NP_064562.1	Q96JP0	FEM1C_HUMAN	fem-1 homolog c (C. elegans)	143						cytoplasm				breast(5)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	18		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		GTTTGACACTTCCAAATCAGC	0.403000													4	121					0	0	1	0	0
HTR1B	3351	broad.mit.edu	37	6	78172192	78172192	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr6:78172192C>T	ENST00000369947.2	-	1	1298	c.929G>A	c.(928-930)cGc>cAc	p.R310H		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	310					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGTGGCTTTGCGCTCCCTAGC	0.522000													5	306					0	0	1	0	0
RACGAP1	29127	broad.mit.edu	37	12	50395035	50395035	+	Splice_Site	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:50395035G>A	ENST00000434422.1	-	8	851	c.549_splice	c.e8-1	p.R184_splice	RACGAP1_ENST00000312377.5_Splice_Site_p.R184_splice|RACGAP1_ENST00000547905.1_Splice_Site_p.R184_splice|RACGAP1_ENST00000454520.2_Splice_Site_p.R184_splice|RACGAP1_ENST00000547061.1_5'UTR|RACGAP1_ENST00000551016.1_Splice_Site_p.R184_splice|RACGAP1_ENST00000427314.2_Splice_Site_p.R184_splice			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	184	Interaction with SLC26A8.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						CTAGTAGAGCGCTAGAAAGGA	0.458000													3	41					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49721622	49721622	+	Splice_Site	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr3:49721622C>T	ENST00000449682.2	-	18	2378	c.2016_splice	c.e18-1	p.G673_splice		NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	659	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCGTAGTCACCCTGGCAGGTA	0.567000													4	40					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48415161	48415161	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr3:48415161G>A	ENST00000296438.5	+	4	438	c.252G>A	c.(250-252)ccG>ccA	p.P84P	FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Silent_p.P84P|FBXW12_ENST00000445170.1_Silent_p.P65P	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	84										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGCACAGCCGCATAACTTTA	0.448000													4	81					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21205843	21205843	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:21205843G>A	ENST00000602326.1	-	18	3028	c.2445C>T	c.(2443-2445)taC>taT	p.Y815Y	EIF4G3_ENST00000264211.8_Silent_p.Y809Y|EIF4G3_ENST00000537738.1_Silent_p.Y299Y|EIF4G3_ENST00000374935.3_Silent_p.Y529Y|EIF4G3_ENST00000374937.3_Silent_p.Y815Y|EIF4G3_ENST00000536266.1_Silent_p.Y413Y|EIF4G3_ENST00000400422.1_Silent_p.Y809Y	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	809	MIF4G.|eIF3/EIF4A-binding (By similarity).				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ACATGTTTGCGTAAGCCACAG	0.443000													5	194					0	0	1	0	0
FGFR1OP2	26127	broad.mit.edu	37	12	27116352	27116352	+	Silent	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:27116352G>A	ENST00000229395.3	+	6	930	c.588G>A	c.(586-588)caG>caA	p.Q196Q	FGFR1OP2_ENST00000327214.5_Silent_p.Q158Q	NM_015633.2	NP_056448.1	Q9NVK5	FGOP2_HUMAN	FGFR1 oncogene partner 2	196						cytoplasm				cervix(1)|large_intestine(4)|lung(1)|prostate(2)	8	Colorectal(261;0.0847)					ACGAGCAACAGGGTTGCAAGG	0.373000													8	57					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000389562.2_Silent_p.Q2726Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													4	109					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284304	152284304	+	Missense_Mutation	SNP	A	A	C			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:152284304A>C	ENST00000368799.1	-	3	3093	c.3058T>G	c.(3058-3060)Tca>Gca	p.S1020A	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1020	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCATGGGATGACGCAGCCTGT	0.582000									Ichthyosis				23	748					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77275824	77275824	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chrX:77275824G>A	ENST00000341514.6	+	13	2865	c.2710G>A	c.(2710-2712)Gca>Aca	p.A904T	ATP7A_ENST00000343533.5_Missense_Mutation_p.A826T|ATP7A_ENST00000350425.4_Intron	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	904					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						GCTTATCTGCGCAACACATGT	0.463000													4	85					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17441719	17441719	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr19:17441719C>T	ENST00000159087.4	-	8	1069	c.911G>A	c.(910-912)cGg>cAg	p.R304Q		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	304						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						AGCCCCTCTCCGCTTCCATTC	0.597000													45	253					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	20					0	0	1	0	0
PCSK9	255738	broad.mit.edu	37	1	55505552	55505553	+	In_Frame_Ins	INS	-	-	CTG	rs35574083		TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr1:55505552_55505553insCTG	ENST00000302118.5	+	1	332_333	c.42_43insCTG	c.(40-45)cctgct>ccCTGtgct	p.14_15PA>PCA	PCSK9_ENST00000452118.2_In_Frame_Ins_p.14_15PA>PCA	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	14					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding	p.P14_L15insL(2)		NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						Ggccgctgccactgctgctgct	0.703													4	6	---	---	---	---					
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													2	4	---	---	---	---					
FAT2	2196	broad.mit.edu	37	5	150891893	150891894	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr5:150891893_150891894insGG	ENST00000261800.5	-	20	11749_11750	c.11737_11738insCC	c.(11737-11739)ggafs	p.G3913fs	CTC-251D13.1_ENST00000606930.1_RNA	NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3913	Laminin G-like.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACAGCATCCAGGCAGCCTTCA	0.599													32	110	---	---	---	---					
FAM157B	100132403	broad.mit.edu	37	9	141107536	141107537	+	RNA	INS	-	-	GCA			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr9:141107536_141107537insGCA	ENST00000446912.2	+	0	19_20							P0CG42	F157B_HUMAN																			CGgcagcggcggcagcagcagc	0.545													2	4	---	---	---	---					
TRPV2	51393	broad.mit.edu	37	17	16335490	16335492	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-H7-A6C4-01A-11D-A30E-08	TCGA-H7-A6C4-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464a456c-1c0b-4207-a0be-26778bb69fc7	ea5338b2-979a-4617-8482-b821d0d28014	g.chr17:16335490_16335492delTGC	ENST00000338560.7	+	12	2264_2266	c.1865_1867delTGC	c.(1864-1869)gtg>g	p.VL622del	TRPV2_ENST00000583241.1_3'UTR|TRPV2_ENST00000577397.1_In_Frame_Del_p.VL192del	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	622					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CGCGGCATGGTGCTGCTGCTGCT	0.596													13	141	---	---	---	---